Base de dados : MEDLINE
Pesquisa : D02.455.526.439.880 [Categoria DeCS]
Referências encontradas : 1404 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 141 ir para página                         

  1 / 1404 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28743677
[Au] Autor:Schmidt CW
[Ti] Título:Maiden Voyage of the Collaborative Cross Mouse: Exploring Variability in Animals' Response to Perchloroethylene.
[So] Source:Environ Health Perspect;125(7):074001, 2017 07 24.
[Is] ISSN:1552-9924
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Comportamento Social
Tetracloroetileno
[Mh] Termos MeSH secundário: Animais
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
TJ904HH8SN (Tetrachloroethylene)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1289/EHP2100


  2 / 1404 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28818516
[Au] Autor:Wang G; Wang J; Ansari GAS; Khan MF
[Ad] Endereço:Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
[Ti] Título:Autoimmune potential of perchloroethylene: Role of lipid-derived aldehydes.
[So] Source:Toxicol Appl Pharmacol;333:76-83, 2017 Oct 15.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tetrachloroethene (perchloroethylene, PCE), an ubiquitous environmental contaminant, has been implicated in inducing autoimmunity/autoimmune diseases (ADs), including systemic lupus erythematosus (SLE) and scleroderma in humans. However, experimental evidence suggesting the potential of PCE in mediating autoimmunity is lacking. This study was, therefore, undertaken to explore PCE's potential in inducing/exacerbating an autoimmune response. Six-week old female MRL+/+ mice, in groups of 6 each, were treated with PCE (0.5mg/ml) via drinking water for 12, 18 and 24weeks and markers of autoimmunity and oxidative stress were evaluated. PCE exposure led to significant increases in serum anti-nuclear antibodies (ANA), anti-dsDNA and anti-scleroderma-70 (anti-Scl-70) antibodies at 18weeks and, to a greater extent at 24weeks, suggesting that PCE exposure exacerbated autoimmunity in our animal model. The increases in autoantibodies were associated with time-dependent increases in malondialdehyde (MDA)-protein adducts and their antibodies, as well as significantly decreased levels of antioxidants GSH and SOD. The splenocytes isolated from mice treated with PCE for 18 and 24weeks showed greater Th17 cell proliferation and increased release of IL-17 in culture supernatants following stimulation with MDA-mouse serum albumin adducts, suggesting that MDA-modified proteins may act as an immunologic trigger by activating Th17 cells and contribute to PCE-mediated autoimmunity. Our studies thus provide an experimental evidence that PCE induces/exacerbates an autoimmune response and lipid-derived aldehydes (such as MDA) contribute to this response.
[Mh] Termos MeSH primário: Autoimunidade/efeitos dos fármacos
Malondialdeído/metabolismo
Solventes/toxicidade
Tetracloroetileno/toxicidade
[Mh] Termos MeSH secundário: Animais
Anticorpos/sangue
Proliferação Celular/efeitos dos fármacos
Modelos Animais de Doenças
Feminino
Glutationa/sangue
Interleucina-17/metabolismo
Lipídeos
Lúpus Eritematoso Sistêmico
Camundongos
Ligação Proteica
Escleroderma Sistêmico
Baço/citologia
Superóxido Dismutase/sangue
Células Th17/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies); 0 (Interleukin-17); 0 (Lipids); 0 (Solvents); 4Y8F71G49Q (Malondialdehyde); EC 1.15.1.1 (Superoxide Dismutase); GAN16C9B8O (Glutathione); TJ904HH8SN (Tetrachloroethylene)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE


  3 / 1404 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28716488
[Au] Autor:Azizian MF; Semprini L
[Ad] Endereço:School of Chemical, Biological and Environmental Engineering, 116 Johnson Hall, Oregon State University, Corvallis, OR 97331, United States. Electronic address: mohammad.azizian@oregonstate.edu.
[Ti] Título:Simultaneous anaerobic transformation of carbon tetrachloride to carbon dioxide and tetrachloroethene to ethene in a continuous flow column.
[So] Source:J Contam Hydrol;203:93-103, 2017 Aug.
[Is] ISSN:1873-6009
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The simultaneous anaerobic transformation of tetrachloroethene (PCE) and carbon tetrachloride (CT) was evaluated in a continuous flow column. The column was packed with quartz sand and bioaugmented with the Evanite culture (EV) that is capable of transforming PCE to ethene. Azizian and Semprini (2016) reported that PCE and CT could be simultaneously transformed in the column, with PCE (0.1mM) transformed mainly to ethene and CT (0.015mM) to chloroform (CF) (20%) and an unknown transformation product, likely carbon dioxide (CO ). The fermentation of propionate, formed from lactate fermentation, was inhibited after the transformation of CT, likely from the exposure to CF. Reported here is the second phase of that study where a second bioaugmentation of the EV culture was made to reintroduce a lactate and propionate fermenting population to the column. Effective lactate and propionate fermentation were restored with a H concentration of ~25nM maintained in the column effluent. PCE (0.1mM) was effectively transformed to ethene (~98%) and vinyl chloride (VC) (~2%). Unlabeled CT (0.015 to 0.03mM) was completely transformed with a transient build-up of CF and chloromethane (CM), which were subsequently removed below their detection limits. A series of transient tests were initiated through the addition of carbon-13 labeled CT ( CT), with concentrations gradually increased from 0.03 to 0.10mM. GC-MS analysis of the column effluent showed that C labeled CO ( CO ) was formed, ranging from 82 to 93% of the CT transformed, with the transient increases in CO associated with the increased concentration of CT. A modified COD analysis indicated a lesser amount of CT (18%) was transformed to soluble products, while CO represented 82% the CT transformed. In a final transient test, the influent lactate concentration was decreased from 1.1 to 0.67mM. The transformation of both CT and PCE changed dramatically. Only 59% of the CT was transformed, primarily to CF. CO concentrations gradually decreased to background levels, indicating CO was no longer a transformation product. PCE transformation resulted in the following percentage of products formed: cDCE (60%), VC (36%), and ethene (4%). Incomplete propionate fermentation was also observed, consistent with the build-up of CF and the decrease in H concentrations to approximately 2nM. The results clearly demonstrate that high concentrations of CT were transformed to CO , and effective PCE dehalogenation to ethene was maintained when excess lactate was fed and propionate was effectively fermented. However, when the lactate concentration was reduced, both PCE and CT transformation and propionate fermentation were negatively impacted.
[Mh] Termos MeSH primário: Dióxido de Carbono/metabolismo
Tetracloreto de Carbono/metabolismo
Etilenos/metabolismo
Tetracloroetileno/metabolismo
[Mh] Termos MeSH secundário: Anaerobiose
Biodegradação Ambiental
Reatores Biológicos/microbiologia
Dióxido de Carbono/química
Isótopos de Carbono/análise
Tetracloreto de Carbono/química
Clorofórmio/química
Clorofórmio/metabolismo
Etilenos/química
Halogenação
Tetracloroetileno/química
Cloreto de Vinil/química
Cloreto de Vinil/metabolismo
Poluentes Químicos da Água/química
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbon Isotopes); 0 (Ethylenes); 0 (Water Pollutants, Chemical); 142M471B3J (Carbon Dioxide); 7V31YC746X (Chloroform); 91GW059KN7 (ethylene); CL2T97X0V0 (Carbon Tetrachloride); TJ904HH8SN (Tetrachloroethylene); WD06X94M2D (Vinyl Chloride)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE


  4 / 1404 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28696834
[Au] Autor:Luo YS; Cichocki JA; McDonald TJ; Rusyn I
[Ad] Endereço:a Department of Veterinary Integrative Biosciences , Texas A&M University , College Station , TX , USA.
[Ti] Título:Simultaneous detection of the tetrachloroethylene metabolites S-(1,2,2-trichlorovinyl) glutathione, S-(1,2,2-trichlorovinyl)-L-cysteine, and N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine in multiple mouse tissues via ultra-high performance liquid chromatography electrospray ionization tandem mass spectrometry.
[So] Source:J Toxicol Environ Health A;80(9):513-524, 2017.
[Is] ISSN:1528-7394
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Tetrachloroethylene (perchloroethylene; PERC) is a high-production volume chemical and ubiquitous environmental contaminant that is hazardous to human health. Toxicity attributed to PERC is mediated through oxidative and glutathione (GSH) conjugation metabolites. The conjugation of PERC by glutathione-s-transferase to generate S-(1,2,2-trichlorovinyl) glutathione (TCVG), which is subsequently metabolized to form S-(1,2,2-trichlorovinyl)-L-cysteine (TCVC) is of special importance to human health. Specifically, TCVC may be metabolized to N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine (NAcTCVC) which is excreted through urine, or to electrophilic metabolites that are nephrotoxic and mutagenic. Little is known regarding toxicokinetics of TCVG, TCVC, and NAcTCVC as analytical methods for simultaneous determination of these metabolites in tissues have not yet been reported. Hence, an ultra-high-performance liquid chromatography electrospray ionization tandem mass spectrometry-based method was developed for analysis of TCVG, TCVC, and NAcTCVC in liver, kidneys, serum, and urine. The method is rapid, sensitive, robust, and selective for detection all three analytes in every tissue examined, with limits of detection (LOD) ranging from 1.8 to 68.2 femtomoles on column, depending on the analyte and tissue matrix. This method was applied to quantify levels of TCVG, TCVC, and NAcTCVC in tissues from mice treated with PERC (10 to 1000 mg/kg, orally) with limits of quantitation (LOQ) of 1-2.5 pmol/g in liver, 1-10 pmol/g in kidney, 1-2.5 pmol/ml in serum, and 2.5-5 pmol/ml in urine. This method is useful for further characterization of the GSH conjugative pathway of PERC in vivo and improved understanding of PERC toxicity.
[Mh] Termos MeSH primário: Acetilcisteína/metabolismo
Cromatografia Líquida de Alta Pressão
Glutationa/metabolismo
Espectrometria de Massas por Ionização por Electrospray
Espectrometria de Massas em Tandem
Tetracloroetileno/metabolismo
[Mh] Termos MeSH secundário: Acetilcisteína/sangue
Acetilcisteína/urina
Animais
Glutationa/sangue
Glutationa/urina
Camundongos
Tetracloroetileno/sangue
Tetracloroetileno/urina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
GAN16C9B8O (Glutathione); TJ904HH8SN (Tetrachloroethylene); WYQ7N0BPYC (Acetylcysteine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170712
[St] Status:MEDLINE
[do] DOI:10.1080/15287394.2017.1330585


  5 / 1404 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28672697
[Au] Autor:Nemecek J; Dolinová I; Machácková J; Spánek R; Sevcu A; Lederer T; Cerník M
[Ad] Endereço:Technical University of Liberec, Studentská 2, CZ-461 17, Liberec, Czech Republic; ENACON s.r.o., Krcská 16, CZ-140 00, Prague 4, Czech Republic. Electronic address: jan.nemecek1@tul.cz.
[Ti] Título:Stratification of chlorinated ethenes natural attenuation in an alluvial aquifer assessed by hydrochemical and biomolecular tools.
[So] Source:Chemosphere;184:1157-1167, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Biomolecular and hydrochemical tools were used to evaluate natural attenuation of chlorinated ethenes in a Quaternary alluvial aquifer located close to a historical source of large-scale tetrachloroethylene (PCE) contamination. Distinct stratification of redox zones was observed, despite the aquifer's small thickness (2.8 m). The uppermost zone of the target aquifer was characterised by oxygen- and nitrate-reducing conditions, with mixed iron- to sulphate-reducing conditions dominant in the lower zone, along with indications of methanogenesis. Natural attenuation of PCE was strongly influenced by redox heterogeneity, while higher levels of PCE degradation coincided with iron- to sulphate reducing conditions. Next generation sequencing of the middle and/or lower zones identified anaerobic bacteria (Firmicutes, Chloroflexi, Actinobacteria and Bacteroidetes) associated with reductive dechlorination. The relative abundance of dechlorinators (Dehalococcoides mccartyi, Dehalobacter sp.) identified by real-time PCR in soil from the lower levels supports the hypothesis that there is a significant potential for reductive dechlorination of PCE. Local conditions were insufficiently reducing for rapid complete dechlorination of PCE to harmless ethene. For reliable assessment of natural attenuation, or when designing monitoring or remedial systems, vertical stratification of key biological and hydrochemical markers should be analysed as standard, even in shallow aquifers.
[Mh] Termos MeSH primário: Monitoramento Ambiental
Etilenos/análise
Água Subterrânea/química
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Chloroflexi
Halogenação
Sequenciamento de Nucleotídeos em Larga Escala
Ferro/análise
Tetracloroetileno/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ethylenes); 0 (Water Pollutants, Chemical); 91GW059KN7 (ethylene); E1UOL152H7 (Iron); TJ904HH8SN (Tetrachloroethylene)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE


  6 / 1404 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28572074
[Au] Autor:Cichocki JA; Furuya S; Venkatratnam A; McDonald TJ; Knap AH; Wade T; Sweet S; Chiu WA; Threadgill DW; Rusyn I
[Ad] Endereço:Department of Veterinary Integrative Biosciences.
[Ti] Título:Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population.
[So] Source:Environ Health Perspect;125(5):057006, 2017 05 30.
[Is] ISSN:1552-9924
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Evaluation of interindividual variability is a challenging step in risk assessment. For most environmental pollutants, including perchloroethylene (PERC), experimental data are lacking, resulting in default assumptions being used to account for variability in toxicokinetics and toxicodynamics. OBJECTIVE: We quantitatively examined the relationship between PERC toxicokinetics and toxicodynamics at the population level to test whether individuals with increased oxidative metabolism are be more sensitive to hepatotoxicity following PERC exposure. METHODS: Male mice from 45 strains of the Collaborative Cross (CC) were orally administered a single dose of PERC (1,000 mg/kg) or vehicle (Alkamuls-EL620) and euthanized at various time points (n = 1/strain/time). Concentration­time profiles were generated for PERC and its primary oxidative metabolite trichloroacetate (TCA) in multiple tissues. Toxicodynamic phenotyping was also performed. RESULTS: Significant variability among strains was observed in toxicokinetics of PERC and TCA in every tissue examined. Based on area under the curve (AUC), the range of liver TCA levels spanned nearly an order of magnitude (~8-fold). Expression of liver cytochrome P4502E1 did not correlate with TCA levels. Toxicodynamic phenotyping revealed an effect of PERC on bodyweight loss, induction of peroxisome proliferator activated receptor-alpha (PPARα)-regulated genes, and dysregulation of hepatic lipid homeostasis. Clustering was observed among ) liver levels of PERC, TCA, and triglycerides; ) TCA levels in liver and kidney; and ) TCA levels in serum, brain, fat, and lung. CONCLUSIONS: Using the CC mouse population model, we have demonstrated a complex and highly variable relationship between PERC and TCA toxicokinetics and toxicodynamics at the population level. https://doi.org/10.1289/EHP788.
[Mh] Termos MeSH primário: Tetracloroetileno/toxicidade
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Rim/química
Rim/efeitos dos fármacos
Fígado/química
Fígado/efeitos dos fármacos
Masculino
Camundongos
Oxirredução
PPAR alfa/metabolismo
Tetracloroetileno/administração & dosagem
Tetracloroetileno/farmacocinética
Toxicocinética
Ácido Tricloroacético/análise
Triglicerídeos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (PPAR alpha); 0 (Triglycerides); 5V2JDO056X (Trichloroacetic Acid); TJ904HH8SN (Tetrachloroethylene)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1289/EHP788


  7 / 1404 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28571111
[Au] Autor:Talibov M; Auvinen A; Weiderpass E; Hansen J; Martinsen JI; Kjaerheim K; Tryggvadottir L; Pukkala E
[Ad] Endereço:Faculty of Social Sciences, University of Tampere, Tampere, Finland.
[Ti] Título:Occupational solvent exposure and adult chronic lymphocytic leukemia: No risk in a population-based case-control study in four Nordic countries.
[So] Source:Int J Cancer;141(6):1140-1147, 2017 Sep 15.
[Is] ISSN:1097-0215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to assess the effect of occupational solvent exposure on the risk of adult chronic lymphocytic leukemia (CLL). The current case-control study was nested in the Nordic Occupational Cancer Study (NOCCA) cohort. 20,615 CLL cases diagnosed in 1961-2005 in Finland, Iceland, Norway, and Sweden, and 103,075 population-based controls matched by year of birth, sex, and country were included. Occupational histories for cases and controls were obtained from census records in 1960, 1970, 1980/1981, and 1990. Exposure to selected solvents was estimated by using the NOCCA job-exposure matrix (NOCCA-JEM). Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by using conditional logistic regression models. Overall, nonsignificant CLL risk elevations were observed for methylene chloride, perchloroethylene, and 1,1,1-trichloroethane. Compared to unexposed, significantly increased risks were observed for cumulative perchloroethylene exposure ≤13.3 ppm-years (OR = 1.85, 95% CI 1.16-2.96) and average life-time perchloroethylene exposure ≤2.5 ppm (1.61, 95% CI 1.01-2.56) among women, and cumulative methylene chloride exposure ≤12.5 ppm-years (OR = 1.19, 95% CI 1.01-1.41) and 12.5-74.8 ppm-years (OR = 1.23, 95% CI 1.01-1.51) among men in an analysis with 5 years lag-time, though without dose-response pattern. Decreased CLL risk was observed for aliphatic and alicyclic hydrocarbon solvents and toluene. This study did not support associations for solvent exposure and CLL. Observed weak associations for methylene chloride, perchloroethylene, 1,1,1-trichloroethane exposures, aliphatic and alicyclic hydrocarbons and toluene were not consistent across sexes, and showed no gradient with amount of exposure.
[Mh] Termos MeSH primário: Hidrocarbonetos Clorados/envenenamento
Leucemia Linfocítica Crônica de Células B/epidemiologia
Doenças Profissionais/epidemiologia
Exposição Ocupacional/estatística & dados numéricos
[Mh] Termos MeSH secundário: Idoso
Estudos de Casos e Controles
Estudos de Coortes
Feminino
Seres Humanos
Leucemia Linfocítica Crônica de Células B/induzido quimicamente
Masculino
Cloreto de Metileno/envenenamento
Doenças Profissionais/induzido quimicamente
Exposição Ocupacional/efeitos adversos
Risco
Países Escandinavos e Nórdicos/epidemiologia
Tetracloroetileno/envenenamento
Tricloroetanos/envenenamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrocarbons, Chlorinated); 0 (Trichloroethanes); 113C650IR1 (1,1,1-trichloroethane); 588X2YUY0A (Methylene Chloride); TJ904HH8SN (Tetrachloroethylene)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.30814


  8 / 1404 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28378313
[Au] Autor:Dolinová I; Strojsová M; Cerník M; Nemecek J; Machácková J; Sevcu A
[Ad] Endereço:Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Studentská 2, 461 17, Liberec, Czech Republic.
[Ti] Título:Microbial degradation of chloroethenes: a review.
[So] Source:Environ Sci Pollut Res Int;24(15):13262-13283, 2017 May.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Contamination by chloroethenes has a severe negative effect on both the environment and human health. This has prompted intensive remediation activity in recent years, along with research into the efficacy of natural microbial communities for degrading toxic chloroethenes into less harmful compounds. Microbial degradation of chloroethenes can take place either through anaerobic organohalide respiration, where chloroethenes serve as electron acceptors; anaerobic and aerobic metabolic degradation, where chloroethenes are used as electron donors; or anaerobic and aerobic co-metabolic degradation, with chloroethene degradation occurring as a by-product during microbial metabolism of other growth substrates, without energy or carbon benefit. Recent research has focused on optimising these natural processes to serve as effective bioremediation technologies, with particular emphasis on (a) the diversity and role of bacterial groups involved in dechlorination microbial processes, and (b) detection of bacterial enzymes and genes connected with dehalogenation activity. In this review, we summarise the different mechanisms of chloroethene bacterial degradation suitable for bioremediation and provide a list of dechlorinating bacteria. We also provide an up-to-date summary of primers available for detecting functional genes in anaerobic and aerobic bacteria degrading chloroethenes metabolically or co-metabolically.
[Mh] Termos MeSH primário: Biodegradação Ambiental
Cloreto de Vinil/metabolismo
[Mh] Termos MeSH secundário: Bactérias/metabolismo
Bactérias Aeróbias/metabolismo
Halogenação
Tetracloroetileno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
TJ904HH8SN (Tetrachloroethylene); WD06X94M2D (Vinyl Chloride)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-017-8867-y


  9 / 1404 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28342345
[Au] Autor:Dias CM; Menezes HC; Cardeal ZL
[Ad] Endereço:Departamento de Química, ICEx, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil.
[Ti] Título:Use of exhaled air as an improved biomonitoring method to assess perchloroethylene short-term exposure.
[So] Source:Environ Res;156:108-112, 2017 07.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This paper shows the use of exhaled air as a biomonitoring method to assess perchloroethylene (PERC) environmental and occupational exposure. A sensitive, fast, and solvent free analytical method was developed to determine PERC in ambient and exhaled air of individuals occupationally exposed. The developed method used cold fiber solid phase microextraction (CF-SPME) as the sampling technique, and a standard permeation method to simulation of air matrix. The analysis were conducted by gas chromatography coupled to mass spectrometry (GC/MS). The methods were validated and were found to be precise, linear and sensitive for environmental and biological monitoring. The developed methods were applied to twenty-seven sampling points spread across Belo Horizonte city, Brazil, twenty four dry cleaners, an electroplating industry, a research laboratory, and an automotive paint preparation shop. The results of ambient air analyses ranging from 14.0 to 3205.0µgm with median concentration of 599.0µgm . Furthermore, sampling of exhaled air of individuals occupationally exposed presented results ranging from 6.0 to 2635.0µgm with median concentration of 325.0µgm . The strong correlation observed between ambient and exhaled air (r =0.930) demonstrates that exhaled air is a suitable biomarker for evaluating occupational exposure to PERC.
[Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar/análise
Poluição do Ar em Ambientes Fechados/análise
Monitoramento Ambiental/métodos
Expiração
Exposição Ocupacional
Tetracloroetileno/análise
[Mh] Termos MeSH secundário: Adulto
Idoso
Biomarcadores/análise
Brasil
Testes Respiratórios
Feminino
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Masculino
Meia-Idade
Microextração em Fase Sólida
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Air Pollutants, Occupational); 0 (Biomarkers); TJ904HH8SN (Tetrachloroethylene)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171119
[Lr] Data última revisão:
171119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170326
[St] Status:MEDLINE


  10 / 1404 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28283038
[Au] Autor:Gallagher LG; Webster TF; Aschengrau A
[Ad] Endereço:Department of Epidemiology, Boston University School of Public Health, 715 Albany Street T3E, Boston, MA, 02118, USA. leg@bu.edu.
[Ti] Título:Exploring associations between prenatal solvent exposures and teenage drug and alcohol use: a retrospective cohort study.
[So] Source:Environ Health;16(1):26, 2017 Mar 11.
[Is] ISSN:1476-069X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Investigating the effects of prenatal and childhood exposures on behavioral health outcomes in adolescence is challenging given the lengthy period between the exposure and outcomes. We conducted a retrospective cohort study in Cape Cod, Massachusetts to evaluate the impact of prenatal and early childhood exposure to tetrachloroethylene (PCE)-contaminated drinking water on the occurrence of risk-taking behaviors as a teenager. An increased occurrence of risk-taking behaviors, particularly illicit drug use, was observed in those highly exposed to PCE. We hypothesized that there may be other sources of prenatal solvent exposure such as maternal consumption of alcoholic beverages during pregnancy which might modify the previously observed associations between PCE and risk-taking behaviors and so we conducted an exploratory analysis using available cohort data. The current report presents the results of these analyses and describes the difficulties in conducting research on long-term behavioral effects of early life exposures. METHODS: The exploratory analysis compared a referent group of subjects with no early life exposure to PCE or alcohol (n = 242) to subjects with only alcohol exposure (n = 201), subjects with only PCE exposure (n = 361), and subjects with exposure to both PCE and alcohol (n = 302). Surveys completed by the subject's mother included questions on prenatal alcoholic beverage consumption and available confounding variables such as cigarette smoking and marijuana use. Surveys completed by the subjects included questions on risk-taking behaviors such as alcoholic beverage consumption and illicit drug use as a teenager and available confounding variables. PCE exposure was modeled using a leaching and transport algorithm embedded in water distribution system modeling software that estimated the amount of PCE delivered to a subject's residence during gestation and early childhood. RESULTS: Subjects with early life exposure to both PCE and alcohol had an increased risk of using two or more major drugs as a teen (RR = 1.9 (95% CI 1.2, 3.0)) compared to unexposed subjects. Increased risks for only PCE exposure (RR = 1.6 (95% CI 1.0, 2.4) and only alcohol exposure (RR = 1.3 (95% CI 0.7, 2.1)) were also evident but were smaller than the increased risk associated with both exposures. While available confounding variables were controlled, many relevant social risk factors were not obtained due to limitations in the retrospective study design. CONCLUSIONS: This exploratory analysis found evidence for an additive effect of early life exposure to PCE and alcohol on the risk of use of multiple illicit drugs as a teenager. Because of numerous limitations in this retrospective study, further research is needed to examine longstanding behavioral effects of early life exposures. To be most informative, this research should involve long-term prospective data collection.
[Mh] Termos MeSH primário: Consumo de Bebidas Alcoólicas/epidemiologia
Exposição Materna
Efeitos Tardios da Exposição Pré-Natal
Solventes
Transtornos Relacionados ao Uso de Substâncias/epidemiologia
Tetracloroetileno
Poluentes Químicos da Água
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Massachusetts/epidemiologia
Gravidez
Estudos Retrospectivos
Assunção de Riscos
Drogas Ilícitas
Abastecimento de Água
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Solvents); 0 (Street Drugs); 0 (Water Pollutants, Chemical); TJ904HH8SN (Tetrachloroethylene)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE
[do] DOI:10.1186/s12940-017-0232-6



página 1 de 141 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde