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[PMID]:29377922
[Au] Autor:Sage M; Nadeau M; Forand-Choinière C; Mousseau J; Vandamme J; Berger C; Tremblay-Roy JS; Tissier R; Micheau P; Fortin-Pellerin É
[Ad] Endereço:Department of Pediatrics and Department of Pharmacology and Physiology, Université de Sherbrooke, Sherbrooke, Québec, Canada.
[Ti] Título:Assessing the impacts of total liquid ventilation on left ventricular diastolic function in a model of neonatal respiratory distress syndrome.
[So] Source:PLoS One;13(1):e0191885, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Filling the lung with dense liquid perfluorocarbons during total liquid ventilation (TLV) might compress the myocardium, a plausible explanation for the instability occasionally reported with this technique. Our objective is to assess the impacts of TLV on the cardiovascular system, particularly left ventricular diastolic function, in an ovine model of neonatal respiratory distress syndrome. METHOD: Eight newborns lambs, 3.0 ± 0.4 days (3.2 ± 0.3kg) were used in this crossover experimental study. Animals were intubated, anesthetized and paralyzed. Catheters were inserted in the femoral and pulmonary arteries. A high-fidelity pressure catheter was inserted into the left ventricle. Surfactant deficiency was induced by repeated lung lavages with normal saline. TLV was then conducted for 2 hours using a liquid ventilator prototype. Thoracic echocardiography and cardiac output assessment by thermodilution were performed before and during TLV. RESULTS: Left ventricular end diastolic pressure (LVEDP) (9.3 ± 2.1 vs. 9.2 ± 2.4mmHg, p = 0.89) and dimension (1.90 ± 0.09 vs. 1.86 ± 0.12cm, p = 0.72), negative dP/dt (-2589 ± 691 vs. -3115 ± 866mmHg/s, p = 0.50) and cardiac output (436 ± 28 vs. 481 ± 59ml/kg/min, p = 0.26) were not affected by TLV initiation. Left ventricular relaxation time constant (tau) slightly increased from 21.5 ± 3.3 to 24.9 ± 3.7ms (p = 0.03). Mean arterial systemic (48 ± 6 vs. 53 ± 7mmHg, p = 0.38) and pulmonary pressures (31.3 ± 2.5 vs. 30.4 ± 2.3mmHg, p = 0.61) were stable. As expected, the inspiratory phase of liquid cycling exhibited a small but significant effect on most variables (i.e. central venous pressure +2.6 ± 0.5mmHg, p = 0.001; LVEDP +1.18 ± 0.12mmHg, p<0.001). CONCLUSIONS: TLV was well tolerated in our neonatal lamb model of severe respiratory distress syndrome and had limited impact on left ventricle diastolic function when compared to conventional mechanical ventilation.
[Mh] Termos MeSH primário: Diástole
Modelos Animais de Doenças
Ventilação Líquida/métodos
Síndrome do Desconforto Respiratório do Recém-Nascido/terapia
Função Ventricular Esquerda
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Fluorcarbonetos/farmacocinética
Síndrome do Desconforto Respiratório do Recém-Nascido/fisiopatologia
Ovinos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fluorocarbons); Q1D0Q7R4D9 (perflubron)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191885


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[PMID]:29214539
[Au] Autor:Barroso PJ; Martín J; Santos JL; Aparicio I; Alonso E
[Ad] Endereço:Department of Analytical Chemistry, Escuela Politécnica Superior, University of Seville, C/ Virgen de África 7, 41011, Seville, Spain.
[Ti] Título:Analytical method for the evaluation of the outdoor air contamination by emerging pollutants using tree leaves as bioindicators.
[So] Source:Anal Bioanal Chem;410(2):417-428, 2018 Jan.
[Is] ISSN:1618-2650
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In this work, an analytical method, based on sonication-assisted extraction, clean-up by dispersive solid-phase extraction and determination by liquid chromatography-tandem mass spectrometry, has been developed and validated for the simultaneous determination of 15 emerging pollutants in leaves from four ornamental tree species. Target compounds include perfluorinated organic compounds, plasticizers, surfactants, brominated flame retardant, and preservatives. The method was optimized using Box-Behnken statistical experimental design with response surface methodology and validated in terms of recovery, accuracy, precision, and method detection and quantification limits. Quantification of target compounds was carried out using matrix-matched calibration curves. The highest recoveries were achieved for the perfluorinated organic compounds (mean values up to 87%) and preservatives (up to 88%). The lowest recoveries were achieved for plasticizers (51%) and brominated flame retardant (63%). Method detection and quantification limits were in the ranges 0.01-0.09 ng/g dry matter (dm) and 0.02-0.30 ng/g dm, respectively, for most of the target compounds. The method was successfully applied to the determination of the target compounds on leaves from four tree species used as urban ornamental trees (Citrus aurantium, Celtis australis, Platanus hispanica, and Jacaranda mimosifolia). Graphical abstract Analytical method for the biomonitorization of emerging pollutants in outdoor air.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/análise
Fluorcarbonetos/análise
Folhas de Planta/química
Extração em Fase Sólida/métodos
Espectrometria de Massas em Tandem/métodos
Árvores/química
[Mh] Termos MeSH secundário: Poluição do Ar/análise
Cromatografia Líquida de Alta Pressão/métodos
Citrus/química
Biomarcadores Ambientais
Retardadores de Chama/análise
Limite de Detecção
Plastificantes/análise
Sonicação/métodos
Tensoativos/análise
Ulmaceae/química
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Environmental Biomarkers); 0 (Flame Retardants); 0 (Fluorocarbons); 0 (Plasticizers); 0 (Surface-Active Agents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1007/s00216-017-0733-8


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[PMID]:28985536
[Au] Autor:Li L; Li X; Chen X; Chen Y; Liu J; Chen F; Ge F; Ye L; Lian Q; Ge RS
[Ad] Endereço:Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 Xueyuan West Road, Wenzhou, Zhejiang 325027, China.
[Ti] Título:Perfluorooctane sulfonate impairs rat Leydig cell development during puberty.
[So] Source:Chemosphere;190:43-53, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Perfluorooctane sulfonate (PFOS) possibly delays male sexual development. However, its effects on pubertal Leydig cell development are unclear. The objective of the present study was to investigate the effects of in vivo PFOS exposure on rat Leydig cell development during puberty. Immature male Sprague Dawley rats were gavaged 5 or 10 mg/kg PFOS on postnatal day 35 for 21 days. Compared to the control (0 mg/kg), PFOS lowered serum testosterone levels without altering luteinizing hormone and follicle-stimulating hormone levels on postnatal day 56. PFOS in vivo downregulated mRNA or protein levels of Leydig cells (Lhcgr, Cyp11a1, and Cyp17a1). PFOS in vitro inhibited androgen secretion in immature Leydig cells at ≥ 50 nM, most possibly via downregulating Hsd17b3 mRNA level. At ≥ 500 nM, PFOS downregulated Lhcgr, inhibited BCL-2 and increased BAX levels to cause Leydig cell apoptosis. In conclusion, PFOS at a lower dose directly inhibited pubertal development of Leydig cells.
[Mh] Termos MeSH primário: Ácidos Alcanossulfônicos/toxicidade
Fluorcarbonetos/toxicidade
Células Intersticiais do Testículo/efeitos dos fármacos
Maturidade Sexual/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Regulação para Baixo
Células Intersticiais do Testículo/patologia
Hormônio Luteinizante/efeitos dos fármacos
Hormônio Luteinizante/metabolismo
Masculino
Proteínas/efeitos dos fármacos
Proteínas/metabolismo
RNA Mensageiro/metabolismo
Ratos
Ratos Sprague-Dawley
Testosterona/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanesulfonic Acids); 0 (Fluorocarbons); 0 (Proteins); 0 (RNA, Messenger); 3XMK78S47O (Testosterone); 9002-67-9 (Luteinizing Hormone); 9H2MAI21CL (perfluorooctane sulfonic acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


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[PMID]:28453957
[Au] Autor:Teng Z; Wang R; Zhou Y; Kolios M; Wang Y; Zhang N; Wang Z; Zheng Y; Lu G
[Ad] Endereço:Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002 Jiangsu, PR China; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093 Jiangsu, PR China.
[Ti] Título:A magnetic droplet vaporization approach using perfluorohexane-encapsulated magnetic mesoporous particles for ultrasound imaging and tumor ablation.
[So] Source:Biomaterials;134:43-50, 2017 Jul.
[Is] ISSN:1878-5905
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Phase change agents consisting of low boiling point perfluorocarbon (PFC) compounds have attracted increasing attention for ultrasound contrast-enhanced imaging and tumor therapy. However, the refraction, acoustic shadowing, reverberation, or limited penetration depth hamper their practical applications through previously reported acoustic droplet vaporization (ADV) or optical droplet vaporization (ODV) technique. Herein, we demonstrate a magnetic droplet vaporization (MDV) approach by loading perflurohexane (PFH) in magnetic mesoporous particles with a hollow space to carry out ultrasound imaging and tumor ablation. In vitro and in vivo magnetic thermal effects show that magnetic energy can be efficiently transformed into thermal energy by the PFH-encapsulated magnetic mesoporous particles, and then leading to vaporization of the loaded PFH. Owing to the generation of the PFH gas bubbles, the ultrasound signals are greatly improved in both harmonic mode and B mode. Simultaneously, anti-cancer experiments demonstrate that the tumor can be ablated after treating with the MDV method for 4 days, demonstrating highly efficient anti-cancer effects.
[Mh] Termos MeSH primário: Fluorcarbonetos/química
Ultrassonografia/métodos
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Sobrevivência Celular/fisiologia
Meios de Contraste/química
Feminino
Células HEK293
Seres Humanos
Camundongos
Camundongos Endogâmicos BALB C
Neoplasias/diagnóstico por imagem
Neoplasias/terapia
Volatilização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (Fluorocarbons); FX3WJ41CMX (perflexane)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:29229332
[Au] Autor:Aparicio I; Martín J; Abril C; Santos JL; Alonso E
[Ad] Endereço:Department of Analytical Chemistry, Escuela Politécnica Superior, University of Seville, C/ Virgen de África 7, E-41011 Seville, Spain. Electronic address: iaparicio@us.es.
[Ti] Título:Determination of household and industrial chemicals, personal care products and hormones in leafy and root vegetables by liquid chromatography-tandem mass spectrometry.
[So] Source:J Chromatogr A;1533:49-56, 2018 Jan 19.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A multiresidue method has been developed for the determination of emerging pollutants in leafy and root vegetables. Selected compounds were 6 perfluoroalkyl compounds (5 perfluorocarboxylic acids and perfluorooctanesulfonic acid), 3 non-ionic surfactants (nonylphenol and nonylphenolethoxylates), 8 anionic surfactants (4 alkylsulfates and 4 linear alkylbenzene sulfonates), 4 preservatives (parabens), 2 biocides (triclosan and triclocarban), 2 plasticizers (bisphenol A and di-(2-ethylhexyl)phthalate), 6 UV-filters (benzophenones) and 4 hormones. The method is based on ultrasound-assisted extraction, clean-up by dispersive solid-phase extraction (d-SPE) and liquid chromatography-tandem mass spectrometry analysis. Due to the diversity of the physico-chemical properties of the target compounds, and to better evaluate the influence of sample treatment variables in extraction efficiencies, Box-Behnken design was applied to optimize extraction solvent volume, number of extraction cycles and d-SPE sorbent amount. Linearity (R ) higher than 0.992, accuracy (expressed as relative recoveries) in the range from 81 to 126%, precision (expressed as relative standard deviation) lower than 19% and limits of detection between 0.025 and 12.5ngg dry weight were achieved. The method was applied to leafy vegetables (lettuce, spinach and chard) and root vegetables (carrot, turnip and potato) from a local market. The highest concentrations corresponded to the surfactants reaching levels up to 114ngg (dry weight), in one of the lettuce samples analyzed.
[Mh] Termos MeSH primário: Cromatografia Líquida
Poluentes Ambientais/análise
Análise de Alimentos/métodos
Hormônios/análise
Compostos Orgânicos/análise
Espectrometria de Massas em Tandem
Verduras/química
[Mh] Termos MeSH secundário: Ácidos Alcanossulfônicos/análise
Compostos Benzidrílicos/análise
Fluorcarbonetos/análise
Análise de Alimentos/normas
Limite de Detecção
Parabenos/análise
Fenóis/análise
Ácidos Ftálicos/análise
Plastificantes/análise
Conservantes Farmacêuticos/análise
Extração em Fase Sólida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanesulfonic Acids); 0 (Benzhydryl Compounds); 0 (Environmental Pollutants); 0 (Fluorocarbons); 0 (Hormones); 0 (Organic Chemicals); 0 (Parabens); 0 (Phenols); 0 (Phthalic Acids); 0 (Plasticizers); 0 (Preservatives, Pharmaceutical); 0 (alkylbenzyl sulfonic acid); 6O7F7IX66E (phthalic acid); 79F6A2ILP5 (nonylphenol); 9H2MAI21CL (perfluorooctane sulfonic acid); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE


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[PMID]:29360450
[Au] Autor:Song Z; Ye Y; Zhang Z; Shen J; Hu Z; Wang Z; Zheng J
[Ad] Endereço:Department of Orthopaedics, Suining Central Hospital, Sichuan, People's Republic of China.
[Ti] Título:Noninvasive, targeted gene therapy for acute spinal cord injury using LIFU-mediated BDNF-loaded cationic nanobubble destruction.
[So] Source:Biochem Biophys Res Commun;496(3):911-920, 2018 02 12.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Various gene delivery systems have been widely studied for the acute spinal cord injury (SCI) treatment. In the present study, a novel type of brain-derived neurotrophic factor (BDNF)-loaded cationic nanobubbles (CNBs) conjugated with MAP-2 antibody (mAb /BDNF/CNBs) was prepared to provide low-intensity focused ultrasound (LIFU)-targeted gene therapy. In vitro experiments, the ultrasound-targeted tranfection to BDNF overexpressioin in neurons and efficiently inhibition neuronal apoptosis have been demonstrated, and the elaborately designed mAb /BDNF/CNBs can specifically target to the neurons. Furthermore, in a acute SCI rat model, LIFU-mediated mAb /BDNF/CNBs transfection significantly increased BDNF expression, attenuated histological injury, decreased neurons loss, inhibited neuronal apoptosis in injured spinal cords, and increased BBB scores in SCI rats. LIFU-mediated mAb /BDNF/CNBs destruction significantly increase transfection efficiency of BDNF gene both in vitro and in vivo, and has a significant neuroprotective effect on the injured spinal cord. Therefore, the combination of LIFU irradiation and gene therapy through mAb /BDNF/CNBs can be considered as a novel non-invasive and targeted treatment for gene therapy of SCI.
[Mh] Termos MeSH primário: Fator Neurotrófico Derivado do Encéfalo/administração & dosagem
Preparações de Ação Retardada/administração & dosagem
Terapia Genética/métodos
Nanocápsulas/efeitos da radiação
Sonicação/métodos
Traumatismos da Medula Espinal/genética
Traumatismos da Medula Espinal/terapia
[Mh] Termos MeSH secundário: Doença Aguda
Animais
Fator Neurotrófico Derivado do Encéfalo/genética
Cátions
Fluorcarbonetos/efeitos da radiação
Marcação de Genes/métodos
Ondas de Choque de Alta Energia
Masculino
Terapia de Alvo Molecular/métodos
Nanocápsulas/química
Nanosferas/química
Nanosferas/efeitos da radiação
Ratos
Ratos Sprague-Dawley
Traumatismos da Medula Espinal/patologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Brain-Derived Neurotrophic Factor); 0 (Cations); 0 (Delayed-Action Preparations); 0 (Fluorocarbons); 0 (Nanocapsules); 0 (brain-derived neurotrophic factor, human); CK0N3WH0SR (perflutren)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE


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[PMID]:28987408
[Au] Autor:Liu QS; Hao F; Sun Z; Long Y; Zhou Q; Jiang G
[Ad] Endereço:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, PR China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, PR China.
[Ti] Título:Perfluorohexadecanoic acid increases paracellular permeability in endothelial cells through the activation of plasma kallikrein-kinin system.
[So] Source:Chemosphere;190:191-200, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Per- and polyfluoroalkyl substances (PFASs) are ubiquitous and high persistent in human blood, thus potentially inducing a myriad of deleterious consequences. Plasma kallikrein-kinin system (KKS), which physiologically regulates vascular permeability, is vulnerable to exogenous stimulators, like PFASs with long-chain alkyl backbone substituted by electronegative fluorine. The study on the interactions of PFASs with the KKS and the subsequent effects on vascular permeability would be helpful to illustrate how the chemicals penetrate the biological vascular barriers to reach different tissues. In present study, three representative PFASs, including perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA) and perfluorohexadecanoic acid (PFHxDA), were investigated for their effects on the activation of the KKS, paracellular permeability in human retina endothelial cells (HRECs) and integrity of the adherens junctions. In contrast to either PFOS or PFOA, PFHxDA efficiently triggered KKS activation in a concentration-dependent manner based on protease activity assays. The plasma activated by PFHxDA significantly increased paracellular permeability of HRECs through the degradation of adherens junctions. As evidenced by the antagonistic effect of aprotinin, PFHxDA-involved effects on vascular permeability were mediated by KKS activation. The results herein firstly revealed the mechanistic pathway for PFHxDA induced effects on vascular endothelial cells. Regarding the possible structure-related activities of the chemicals, this finding would be of great help in the risk assessment of PFASs.
[Mh] Termos MeSH primário: Permeabilidade Capilar/efeitos dos fármacos
Células Endoteliais/metabolismo
Fluorcarbonetos/farmacologia
Sistema Calicreína-Cinina/efeitos dos fármacos
Ácido Palmítico/farmacologia
[Mh] Termos MeSH secundário: Junções Aderentes/metabolismo
Ácidos Alcanossulfônicos/farmacologia
Caprilatos/farmacologia
Células Cultivadas
Células Endoteliais/fisiologia
Seres Humanos
Sistema Calicreína-Cinina/fisiologia
Plasma/efeitos dos fármacos
Retina/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanesulfonic Acids); 0 (Caprylates); 0 (Fluorocarbons); 2V16EO95H1 (Palmitic Acid); 947VD76D3L (perfluorooctanoic acid); 9H2MAI21CL (perfluorooctane sulfonic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171009
[St] Status:MEDLINE


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[PMID]:29017113
[Au] Autor:Man YB; Chow KL; Tsang YF; Lau FTK; Fung WC; Wong MH
[Ad] Endereço:Consortium on Health, Environment, Education and Research (CHEER), and Department of Science and Environmental Studies, The Education University of Hong Kong, Tai Po, Hong Kong, China.
[Ti] Título:Fate of bisphenol A, perfluorooctanoic acid and perfluorooctanesulfonate in two different types of sewage treatment works in Hong Kong.
[So] Source:Chemosphere;190:358-367, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study aimed at investigating the removal efficiencies of perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS) and bisphenol A (BPA) of two major sewage treatment works in Hong Kong: Stonecutters Island STW (SCISTW) which adopts chemically enhanced primary treatment (CEPT) process and Sha Tin STW (STSTW) which employs biological treatment. Liquid portion (LP) and particulate matter (PM) of liquid sewage samples and sludge samples were collected and followed by liquid chromatograph system. It was found that BPA (44.6 ± 35.1%) generally achieved higher TRE than the two other chemicals (PFOS (-18.8 ± 34.8%) and PFOA (-104 ± 86.8%)) in STSTW (p < 0.05). Most of the PFOA, PFOS and BPA was discharged through final effluent (PFOA: 95.6 ± 1.00% and 94.5 ± 3.13%; PFOS: 77.7 ± 1.48% and 72.6 ± 6.07%; BPA: 99.2 ± 0.950% and 92.8 ± 7.25%, respectively) rather than stored in the sludge/cake (PFOA: 4.45 ± 1.00% and 5.47 ± 3.13%, PFOS: 22.3 ± 1.48% and 27.4 ± 6.07%, BPA: 0.844 ± 0.950% and 7.20 ± 7.25%, respectively). After the sewage purification process, the two STW released considerable amounts of PFOA, PFOS and BPA in the final effluent (PFOA: 0.638 ± 0.227 kg/year; PFOS: 0.409 ± 0.126 kg/year; BPA: 10.4 ± 3.83 kg/year in STSTW; PFOA: 3.08 ± 1.415 kg/year; PFOS: 2.13 ± 0.452 kg/year; BPA: 714 ± 768 kg/year in SCISTW) and in the sludge (PFOA: 0.0360 ± 0.0250 kg/year; PFOS: 0.149 ± 0.00100 kg/year; BPA: 1.09 ± 1.47 kg/year in STSTW; PFOA: 0.139 ± 0.0670 kg/year; PFOS: 0.606 ± 0.0780 kg/year; BPA: 3.05 ± 3.95 kg/year in SCISTW). This study may help to provide crucial information for further development of municipal sewage system in treating synthetic emerging chemicals.
[Mh] Termos MeSH primário: Ácidos Alcanossulfônicos/análise
Compostos Benzidrílicos/análise
Caprilatos/análise
Fluorcarbonetos/análise
Fenóis/análise
Gerenciamento de Resíduos/métodos
Gerenciamento de Resíduos/normas
[Mh] Termos MeSH secundário: Cromatografia Líquida
Hong Kong
Esgotos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanesulfonic Acids); 0 (Benzhydryl Compounds); 0 (Caprylates); 0 (Fluorocarbons); 0 (Phenols); 0 (Sewage); 947VD76D3L (perfluorooctanoic acid); 9H2MAI21CL (perfluorooctane sulfonic acid); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE


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[PMID]:28923343
[Au] Autor:Liu HS; Wen LL; Chu PL; Lin CY
[Ad] Endereço:Department of Obstetrics and Gynaecology, Hsinchu Cathay General Hospital, Hsinchu 300, Taiwan.
[Ti] Título:Association among total serum isomers of perfluorinated chemicals, glucose homeostasis, lipid profiles, serum protein and metabolic syndrome in adults: NHANES, 2013-2014.
[So] Source:Environ Pollut;232:73-79, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Perfluorinated chemicals (PFCs) have been used widely in consumer products manufacture. Recent in vitro as well as animal studies have found that there are different toxicity and pharmacokinetic profiles between isomers of perfluorooctanoic acid (PFOA) and/or perfluorooctane sulfonate (PFOS). However, the differential effects of linear or branched PFOA/PFOS isomers on human beings have never been reported. Herein, we examined 1871 adult subjects (age older than 18 years) from the National Health and Nutrition Examination Survey (NHANES) 2013-2014 to determine the association between the isomers of PFOA/PFOS and serum biochemistry profiles, including glucose, lipids, protein and components of metabolic syndrome (MS). The results showed that for PFOA, increased linear PFOA was associated with increases in total cholesterol, serum albumin and an enhancement of ß cell function as well as a decrease in the serum globulin. Increased branched PFOA was significantly associated with increased fasting glucose. All isomers of PFOA were positively associated with high-density lipoprotein-cholesterol (HDL-C) and negatively associated with glycohemoglobin (HbA1C). The branched PFOS was positively associated with ß cell function and inversely associated with serum globulin. Both linear and branched isomers of PFOS were positively associated with the total protein and albumin. The increased branched PFOA was associated with less HDL-C insufficiency defined by the National Cholesterol Education Program Third Adult Treatment Panel (NCEP-ATP III) MS criteria, whereas the increased concentrations of serum total and linear PFOS were associated with less hypertriglyceridemia by the NCEP-ATP III. In conclusion, serum isomers of PFOA and PFOS were associated with glucose homeostasis, serum protein as well as lipid profiles; they were also indicators of MS. This may suggest that there is a distinct difference in the toxicokinetics of the isomers of PFOA and PFOS. Further clinical and animal studies are warranted to clarify the putative causal relationships between isomers and biochemical alterations.
[Mh] Termos MeSH primário: Exposição Ambiental/estatística & dados numéricos
Poluentes Ambientais/sangue
Fluorcarbonetos/sangue
Síndrome Metabólica/sangue
Inquéritos Nutricionais
[Mh] Termos MeSH secundário: Adulto
Ácidos Alcanossulfônicos
Animais
Proteínas Sanguíneas
Caprilatos
Colesterol
Feminino
Glucose
Homeostase
Seres Humanos
Isomerismo
Lipídeos/sangue
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanesulfonic Acids); 0 (Blood Proteins); 0 (Caprylates); 0 (Environmental Pollutants); 0 (Fluorocarbons); 0 (Lipids); 947VD76D3L (perfluorooctanoic acid); 97C5T2UQ7J (Cholesterol); 9H2MAI21CL (perfluorooctane sulfonic acid); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE


  10 / 9694 MEDLINE  
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[PMID]:28749778
[Au] Autor:Grandjean P; Heilmann C; Weihe P; Nielsen F; Mogensen UB; Budtz-Jørgensen E
[Ad] Endereço:Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
[Ti] Título:Serum Vaccine Antibody Concentrations in Adolescents Exposed to Perfluorinated Compounds.
[So] Source:Environ Health Perspect;125(7):077018, 2017 07 26.
[Is] ISSN:1552-9924
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Postnatal exposure to perfluorinated alkylate substances (PFASs) is associated with lower serum concentrations of specific antibodies against certain childhood vaccines at 7 y. OBJECTIVES: We prospectively followed a Faroese birth cohort to determine these associations at 13 y. METHODS: In 516 subjects (79% of eligible cohort members) who were 13 years old, serum concentrations of PFASs and of antibodies against diphtheria and tetanus were measured and were compared with data from the previous examination at 7 y. Multiple regression analyses and structural equation models were applied to determine the association between postnatal PFAS exposures and antibody concentrations. RESULTS: Serum concentrations of PFASs and antibodies generally declined from 7 y to 13 y. However, 68 subjects had visited the emergency room and had likely received a vaccination booster, and a total of 202 children showed higher vaccine antibody concentrations at 13 y than at 7 y. Therefore, separate analyses were conducted after exclusion of these two subgroups. Diphtheria antibody concentrations decreased at elevated PFAS concentrations at 13 y and 7 y; the associations were statistically significant for perfluorodecanoate (PFDA) at 7 y and for perfluorooctanoate (PFOA) at 13 y, both suggesting a decrease by ∼25% for each doubling of exposure. Structural equation models showed that a doubling in PFAS exposure at 7 y was associated with losses in diphtheria antibody concentrations at 13 y of 10­30% for the five PFASs. Few associations were observed for anti-tetanus concentrations. CONCLUSIONS: These results are in accord with previous findings of PFAS immunotoxicity at current exposure levels. https://doi.org/10.1289/EHP275.
[Mh] Termos MeSH primário: Anticorpos Antibacterianos/sangue
Toxoide Diftérico/imunologia
Exposição Ambiental
Poluentes Ambientais/sangue
Fluorcarbonetos/sangue
Ácidos Sulfônicos/sangue
Toxoide Tetânico/imunologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Dinamarca
Toxoide Diftérico/administração & dosagem
Monitoramento Ambiental
Feminino
Seres Humanos
Masculino
Estudos Prospectivos
Toxoide Tetânico/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Diphtheria Toxoid); 0 (Environmental Pollutants); 0 (Fluorocarbons); 0 (Sulfonic Acids); 0 (Tetanus Toxoid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1289/EHP275



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