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[PMID]:28960960
[Au] Autor:Lv S; Zhang Y; Xu B; Xu H; Zhao Y; Chen J; Gao Z; Wu J; Xie J
[Ad] Endereço:State Key Laboratory of Toxicology and Medical Countermeasures and Laboratory of Toxicant Analysis, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences , 27 Taiping Road, Haidian District, Beijing 100850, China.
[Ti] Título:Synthesis, Characterization, and Identification of New in Vitro Covalent DNA Adducts of Divinyl Sulfone, an Oxidative Metabolite of Sulfur Mustard.
[So] Source:Chem Res Toxicol;30(10):1874-1882, 2017 Oct 16.
[Is] ISSN:1520-5010
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Divinyl sulfone (DVS) is an important oxidative metabolic product of sulfur mustard (SM) in vitro and in vivo. Although DVS is not a classical blister agent, its high reactivity and toxicity induced by vinyl groups can also cause blisters like SM upon contact with the skin, eyes, and respiratory organs. The purpose of this paper was to identify whether DVS could covalently bind to DNA bases to form new DNA adducts in cells in vitro. A series of adducts were synthesized and characterized using purine, nucleoside, or DNA, separately, as starting materials. The covalent site, pattern, and relative reactivity of adduct formation were identified and discussed in detail. The results showed that five high abundance site-specific DNA adducts, including two monoadducts and three cross-linked adducts, were obtained when DNA was used as a substrate. When HaCaT cells were exposed to 30 µM of DVS, four new DNA adducts containing monoadducts and cross-linked adducts were found and identified in cells, including N3-A monoadduct, N7-G monoadduct, N7G-N7G bis-adduct, and N3A-N7G cross-linked adduct. Among them, the abundance of N3-A monoadduct was 10 times higher than that of the other three adducts. DNA adduct formation with DVS showed significant differences from that observed with SM. The observation of these new DNA adduct in vitro cells revealed that DNA damage could be also induced by DVS.
[Mh] Termos MeSH primário: Adutos de DNA/efeitos dos fármacos
Gás de Mostarda/metabolismo
Sulfonas/farmacologia
[Mh] Termos MeSH secundário: Células Cultivadas
Adutos de DNA/química
Dano ao DNA
Relação Dose-Resposta a Droga
Seres Humanos
Estrutura Molecular
Gás de Mostarda/química
Oxirredução/efeitos dos fármacos
Relação Estrutura-Atividade
Sulfonas/análise
Sulfonas/síntese química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA Adducts); 0 (Sulfones); 5PFN71LP8M (divinyl sulfone); T8KEC9FH9P (Mustard Gas)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170930
[St] Status:MEDLINE
[do] DOI:10.1021/acs.chemrestox.7b00196


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[PMID]:28495614
[Au] Autor:Jost P; Fikrova P; Svobodova H; Pejchal J; Stetina R
[Ad] Endereço:Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic. Electronic address:
[Ti] Título:Protective potential of different compounds and their combinations with MESNA against sulfur mustard-induced cytotoxicity and genotoxicity.
[So] Source:Toxicol Lett;275:92-100, 2017 Jun 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to evaluate the efficacy of potential candidate molecules or their combinations against strong alkylation agent sulfur mustard (SM) on the human lung alveolar epithelial cell line A-549. Candidate molecules were chosen on the basis of their previously observed protective effects in vitro. The tested compounds, including antioxidants, sulfhydryl or other sulfur-containing molecules, nitrogen-containing molecules, PARP inhibitors and a NO synthase inhibitor, were applicated 30min before SM treatment. The efficiency of candidate molecules to protect cells against DNA damage and cell death induced by SM was determined using single-cell gel electrophoresis (comet assay) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction by viable cells. The damage of DNA was assessed 1 and 24h after dose 50µM SM. Cell survival was assessed 24 and 72h after the exposure. To achieve maximal cytoprotection, combinations of selected compounds with sodium 2-mercaptoethane sulphonate (MESNA) were tested. We found significant protective effects by several drugs used individually and also in combination with MESNA. High protection was achieved by sodium thiosulphate, which was further potentiated when combined with MESNA. Most of the selected compounds or mixture provided only moderate genoptotection without having any effect towards cell viability.
[Mh] Termos MeSH primário: Dano ao DNA
Mesna/farmacologia
Gás de Mostarda/toxicidade
Mutagênicos/toxicidade
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Células A549
Técnicas de Cultura de Células
Sobrevivência Celular/efeitos dos fármacos
Ensaio Cometa
Citoproteção
Sinergismo Farmacológico
Seres Humanos
Mesna/química
Substâncias Protetoras/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mutagens); 0 (Protective Agents); NR7O1405Q9 (Mesna); T8KEC9FH9P (Mustard Gas)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE


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[PMID]:28360112
[Au] Autor:Andres DK; Keyser BM; Melber AA; Benton BJ; Hamilton TA; Kniffin DM; Martens ME; Ray R
[Ad] Endereço:Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Aberdeen, Maryland devon.k.andres.ctr@mail.mil.
[Ti] Título:Apoptotic cell death in rat lung following mustard gas inhalation.
[So] Source:Am J Physiol Lung Cell Mol Physiol;312(6):L959-L968, 2017 Jun 01.
[Is] ISSN:1522-1504
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To investigate apoptosis as a mechanism of sulfur mustard (SM) inhalation injury in animals, we studied different caspases (caspase-8, -9, -3, and -6) in the lungs from a ventilated rat SM aerosol inhalation model. SM activated all four caspases in cells obtained from bronchoalveolar lavage fluid (BALF) as early as 6 h after exposure. Caspase-8, which is known to initiate the extrinsic Fas-mediated pathway of apoptosis, was increased fivefold between 6 and 24 h, decreasing to the unexposed-control level at 48 h. The initiator, caspase-9, in the intrinsic mitochondrial pathway of apoptosis as well as the executioner caspases, caspase-3 and -6, all peaked ( < 0.01) at 24 h; caspase-3 and -6 remained elevated, but caspase-9 decreased to unexposed-control level at 48 h. To study further the Fas pathway, we examined soluble as well as membrane-bound Fas ligand (sFas-L and mFas-L, respectively) and Fas receptor (Fas-R) in both BALF cells and BALF. At 24 h after SM exposure, sFas-L increased significantly in both BALF cells ( < 0.01) and BALF ( < 0.05). However, mFas-L increased only in BALF cells between 24 and 48 h ( < 0.1 and < 0.001, respectively). Fas-R increased only in BALF cells by 6 h ( < 0.01) after SM exposure. Apoptosis in SM-inhaled rat lung specimens was also confirmed by both immunohistochemical staining using cleaved caspase-3 and -9 antibodies and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining as early as 6 h in the proximal trachea and bronchi, but not before 48 h in distal airways. These findings suggest pathogenic mechanisms at the cellular and molecular levels and logical therapeutic target(s) for SM inhalation injury in animals.
[Mh] Termos MeSH primário: Apoptose
Exposição por Inalação
Pulmão/patologia
Gás de Mostarda/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Líquido da Lavagem Broncoalveolar/citologia
Caspases/metabolismo
Ativação Enzimática
Proteína Ligante Fas/metabolismo
Imuno-Histoquímica
Marcação In Situ das Extremidades Cortadas
Pulmão/enzimologia
Masculino
Ratos Sprague-Dawley
Transdução de Sinais
Solubilidade
Fatores de Tempo
Receptor fas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fas Ligand Protein); 0 (fas Receptor); EC 3.4.22.- (Caspases); T8KEC9FH9P (Mustard Gas)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1152/ajplung.00281.2015


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[PMID]:28356208
[Au] Autor:Razavi SM; Saghafinia M; Salamati P
[Ad] Endereço:Department of Community Medicine, Tehran University of Medical Sciences, Tehran, Iran.
[Ti] Título:Paraclinical findings in Iranian veterans exposed to sulfur mustard gas: A literature review.
[So] Source:Chin J Traumatol;20(2):114-117, 2017 Apr.
[Is] ISSN:1008-1275
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Sulfur mustard (SM) causes various systemic disturbances in human beings. This study aimed to assess paraclinical changes caused by exposure to SM gas in Iranian veterans during the war between Iraq and Iran. METHODS: A literature review was carried out in international and national medical databases including ISI, Medline, Scopus, Iranmedex and Irandoc. Both Farsi and English literature were searched. RESULTS: Search of the literature yielded 422 medical articles related to SM poisoning. Among them, 30 relevant articles were thoroughly reviewed. The most important reported complications were leukopenia, neutropenia, lymphopenia, eosinophilia, thrombocytopenia, increased bleeding time, positive C-reactive protein (CRP), rheumatoid factor (RF), antinuclear antibody (ANA), decreased T helper cells, natural killer cells, IL6, and IL8 levels, elevation of serum immunoglobulins, decreased levels of T3, T4 and cortisol, increased level of adrenocorticotropic hormone (ACTH), proteinuria, hematuria, and elevated liver enzymes. Also, there were some changes in chest assessments. CONCLUSIONS: SM causes profound systemic complications in victims, even years after exposure. The paraclinical changes can be observed in hematology, immune system, biochemistry, hormonal profile and some imaging studies.
[Mh] Termos MeSH primário: Substâncias para a Guerra Química/envenenamento
Gás de Mostarda/envenenamento
Veteranos
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Hormônios/sangue
Seres Humanos
Sistema Imunitário/efeitos dos fármacos
Masculino
Imagem de Perfusão do Miocárdio
Espirometria
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Chemical Warfare Agents); 0 (Hormones); EC 2.6.1.2 (Alanine Transaminase); T8KEC9FH9P (Mustard Gas)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE


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[PMID]:28285101
[Au] Autor:Sawyer TW; McNeely K; Louis K; Lecavalier P; Song Y; Villanueva M; Clewley R
[Ad] Endereço:Defence Research & Development Canada, Suffield Research Center, Box 4000, Medicine Hat, Alberta, T1A 8K6, Canada. Electronic address: Thomas.Sawyer@drdc-rddc.gc.ca.
[Ti] Título:Comparative toxicity of mono- and bifunctional alkylating homologues of sulphur mustard in human skin keratinocytes.
[So] Source:Toxicology;382:36-46, 2017 May 01.
[Is] ISSN:1879-3185
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Sulphur mustard (bis(2-chloroethyl) sulphide; agent H) is a vesicant chemical warfare (CW) agent whose mechanism of action is not known with any certainty and for which there are no effective antidotes. It has a pronounced latent period before signs and symptoms of poisoning appear which it shares with the nitrogen mustards, and that differentiates it from other classes of vesicant agents. Sulphur mustard, the sulphur mustard CW agents Q (1,2-bis(2-chloroethylthio) ethane) and T (1,1 bis(2-chloroethylthioethyl) ether), the H partial hydrolysis product hemi-sulphur mustard (2-chloroethyl 2-hydroxyethyl sulphide; HSM), and the commercially available 2-chloroethyl ethyl sulphide (CEES) were characterized with respect to their toxicity in first passage cultures of proliferating human skin keratinocytes, the target cell of H-induced skin vesication. Agents H and T were equitoxic and half as toxic as agent Q. Hemi-sulphur mustard and CEES were approximately six times and seventeen times, respectively less cytotoxic than H. 2-Chloroethyl ethyl sulphide was only slightly less toxic in confluent cultures compared to actively proliferating cells. In contrast, the toxicity of H, Q, T and HSM significantly decreased as the cultures became confluent, paralleling the decreasing sensitivity of skin keratinocytes to H as they leave the basement membrane of the skin. The toxicity of CEES was maximal by 24h. In contrast, the maximal toxicity of the other four agents occurred at 48h, mirroring the latent period observed for these agents in vivo. The markedly different characteristics of toxicity between CEES and the other four test compounds indicate that it is likely that different mechanisms of action are operative between them. Caution should therefore be taken when interpreting the results of studies utilizing CEES as a simulant for the mechanistic study of H, or in the elucidation of medical countermeasures against this CW agent. It is also notable that the toxicity characteristics of the mono-alkylating HSM mirrors those of H, Q and T, suggesting that the bi-alkylating characteristics of these latter compounds may not play as large a role in their toxic effects as commonly thought.
[Mh] Termos MeSH primário: Alquilantes/toxicidade
Queratinócitos/efeitos dos fármacos
Gás de Mostarda/análogos & derivados
Gás de Mostarda/toxicidade
[Mh] Termos MeSH secundário: Caspase 3/metabolismo
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Seres Humanos
Queratinócitos/metabolismo
L-Lactato Desidrogenase/metabolismo
Masculino
Pele/citologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkylating Agents); EC 1.1.1.27 (L-Lactate Dehydrogenase); EC 3.4.22.- (Caspase 3); T8KEC9FH9P (Mustard Gas)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


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[PMID]:28284764
[Au] Autor:Liu CC; Liu SL; Xi HL; Yu HL; Zhou SK; Huang GL; Liang LH; Liu JQ
[Ad] Endereço:Laboratory of Analytical Chemistry, Research Institute of Chemical Defence, Beijing 102205, China; State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China.
[Ti] Título:Simultaneous quantification of four metabolites of sulfur mustard in urine samples by ultra-high performance liquid chromatography-tandem mass spectrometry after solid phase extraction.
[So] Source:J Chromatogr A;1492:41-48, 2017 Apr 07.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Four HD urinary metabolites including hydrolysis metabolite thiodiglycol (TDG), glutathione-derived metabolite 1,1'-sulfonylbis[2-S-(N-acetylcysteinyl)ethane] (SBSNAE), as well as the ß-lyase metabolites 1,1'-sulfonylbis[2-(methylsulfinyl)ethane] (SBMSE) and 1-methylsulfinyl-2-[2-(methylthio) ethylsulfonyl]ethane (MSMTESE) are considered as important biomarkers for short-term retrospective detection of HD exposure. In this study, a single method for simultaneous quantification of the four HD metabolites in urine samples was developed using ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The four urinary metabolites were simultaneously extracted from urinary samples using a solid phase extraction (SPE) method with high extraction recoveries for all four metabolites varied in the range of 71.1-103% followed by UHPLC-MS/MS analysis. The SPE is simple and high effective only requiring 0.1mL of urinary samples and 0.5h time consuming. The problem of previous co-elution of TDG and SBSNAE in UHPLC was well solved, and complete separation of TDG, SBSNAE, SBMSE and MSMTESE from SPE-processed urine matrix was obtained to increase specificity and sensitivity. A full method validation was performed for each analyte in urine matrix. The linear range of calibration curves for the four analytes were respectively from 0.50-500ngmL for TDG and SBSNAE, 0.05-500ngmL for SBMSE and MSMTESE with coefficient of determination value (R ) ≥0.990. The limit of detection was 0.25ngmL for TDG and SBSNAE, 0.01ngmL for SBMSE and MSMTESE spiked in normal urine. The intra/inter-day precision for each analyte at three QC levels had relative standard deviation (%RSD) of ≤10.3%, and the intra/inter-day accuracy ranged between 88.0-108%. This developed method allows for simultaneous and trace measurement of four HD urinary metabolites within one single determination with the lowest usage amount of urine samples over all previous methods This study provides a useful tool for early diagnosis and monitoring of HD poisoning for medical treatment with high confidence, avoiding the need for application of several analysis methods.
[Mh] Termos MeSH primário: Substâncias para a Guerra Química/metabolismo
Gás de Mostarda/metabolismo
[Mh] Termos MeSH secundário: Acetatos/química
Biomarcadores/urina
Substâncias para a Guerra Química/análise
Substâncias para a Guerra Química/isolamento & purificação
Cromatografia Líquida de Alta Pressão
Seres Humanos
Gás de Mostarda/análise
Gás de Mostarda/isolamento & purificação
Reprodutibilidade dos Testes
Extração em Fase Sólida
Compostos de Sulfidrila/isolamento & purificação
Compostos de Sulfidrila/urina
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Biomarkers); 0 (Chemical Warfare Agents); 0 (Sulfhydryl Compounds); 9BW5T43J04 (2,2'-thiodiethanol); RRE756S6Q2 (ammonium acetate); T8KEC9FH9P (Mustard Gas)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


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[PMID]:28279874
[Au] Autor:Bevan MJ; Wogen MT; Lunda MD; Saravia SA
[Ad] Endereço:Public Health Laboratory Division, Minnesota Department of Health, 601 Robert St. N, P.O. Box 64899, Saint Paul, MN, 55164, United States. Electronic address: martin.bevan@state.mn.us.
[Ti] Título:High throughput quantitative analysis of the ß-lyase sulfur mustard metabolite, 1,1'-sulfonylbis[2-(methylsulfinyl)ethane] in urine via high performance liquid chromatography tandem mass spectrometry.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1051:1-8, 2017 Apr 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Sulfur Mustard (HD) has a 100year history of use as a chemical warfare agent and recent events in the Middle East are causing it to once again be a potential concern. We report a new high-throughput method for the determination of HD exposure by the analysis of the ß-lyase metabolite 1,1'-sulfonylbis[2-(methylsulfinyl)ethane] (SBMSE) in human urine. This method features a hydrogen peroxide (H O ) oxidative conversion of the ß-lyase metabolites to SBMSE, followed by sample extraction and concentration using solid phase extraction in 96-well plate format. Subsequent high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) analysis gave linear quantitation over a calibration range of 0.1-100ng/mL, with a method detection limit of 0.03ng/mL. Liquid chromatographic separation was achieved using a hydrophilic interaction liquid chromatography (HILIC) column with an analyte retention time of 0.9min and method time of 1.5min (cycle time=2.0min). Users of this method could prepare and analyze approximately 650 samples in 24h which would be important for an emergency response.
[Mh] Termos MeSH primário: Substâncias para a Guerra Química/metabolismo
Cromatografia Líquida de Alta Pressão/métodos
Gás de Mostarda/metabolismo
Sulfonas/urina
Sulfóxidos/urina
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão/instrumentação
Desenho de Equipamento
Ensaios de Triagem em Larga Escala
Seres Humanos
Peróxido de Hidrogênio/metabolismo
Limite de Detecção
Liases/metabolismo
Oxirredução
Extração em Fase Sólida/métodos
Sulfonas/metabolismo
Sulfóxidos/metabolismo
Espectrometria de Massas em Tandem/instrumentação
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Chemical Warfare Agents); 0 (Sulfones); 0 (Sulfoxides); 137371-96-1 (1,1'-sulfonylbis(2-(methylsulfinyl)ethane)); BBX060AN9V (Hydrogen Peroxide); EC 4.- (Lyases); T8KEC9FH9P (Mustard Gas)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE


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[PMID]:28246228
[Au] Autor:Smith SL
[Ad] Endereço:Department of History and Classics, Faculty of Arts, University of Alberta, Edmonton, Alta.
[Ti] Título:War! What is it good for? Mustard gas medicine.
[So] Source:CMAJ;189(8):E321-E322, 2017 02 27.
[Is] ISSN:1488-2329
[Cp] País de publicação:Canada
[La] Idioma:eng
[Mh] Termos MeSH primário: Antineoplásicos/história
Substâncias para a Guerra Química/história
Descoberta de Drogas/história
Mecloretamina/história
Gás de Mostarda/história
[Mh] Termos MeSH secundário: Antineoplásicos/uso terapêutico
História do Século XX
Seres Humanos
Mecloretamina/uso terapêutico
I Guerra Mundial
II Guerra Mundial
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Chemical Warfare Agents); 50D9XSG0VR (Mechlorethamine); T8KEC9FH9P (Mustard Gas)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.161032


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[PMID]:28193081
[Au] Autor:Askari N; Ghazanfari T; Yaraee R; Vaez Mahdavi MR; Soroush MR; Mohammad Hassan Z; Khodashenas Z; Shams J; Faghihzadeh S
[Ad] Endereço:Department of Biology, Faculty of Basic Sciences, Shahid Bahonar, University of Kerman, Kerman, I.R. Iran.
[Ti] Título:Association between Acne and Serum Pro-inflammatory Cytokines (IL-1α, IL-1ß, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in Mustard Gas-Exposed Patients: Sardasht-Iran Cohort Study.
[So] Source:Arch Iran Med;20(2):86-91, 2017 Feb.
[Is] ISSN:1735-3947
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Acne vulgaris is a very common chronic inflammatory disorder, yet its pathogenesis is not clearly understood. As part of the SICS, this study was conducted to evaluate the association between the incidence of acne vulgaris in SM-exposed subjects (20 years after the exposure) and serum levels of proinflammatory cytokines (IL-1α, IL-1ß, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in an attempt to better understand the pathogenesis of long-term skin disorders of these individuals. METHODS: Serum concentrations of cytokines (IL-1α, IL-1ß, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) were measured using sandwich ELISA technique. RESULTS: The median of serum levels of IL-1ß, IL-8 and RANTES were significantly higher in the exposed patients with acne than those without acne (P = 0.05, 0.03 and 0.001 respectively). There was no significant difference in serum levels of IL-1α, IL-1Ra and IL-6 between the exposed subgroups. CONCLUSION: We found a positive association between serum levels of pro-inflammatory cytokines (IL-1ß, IL-8, IL-12 and RANTES) and acne among SM-exposed population.
[Mh] Termos MeSH primário: Acne Vulgar/induzido quimicamente
Quimiocina CCL5/sangue
Citocinas/sangue
Gás de Mostarda/toxicidade
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Seres Humanos
Interleucina-12/sangue
Interleucina-1beta/sangue
Interleucina-8/sangue
Irã (Geográfico)
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CCL5 protein, human); 0 (Chemokine CCL5); 0 (Cytokines); 0 (IL1B protein, human); 0 (IL8 protein, human); 0 (Interleukin-1beta); 0 (Interleukin-8); 187348-17-0 (Interleukin-12); T8KEC9FH9P (Mustard Gas)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170303
[Lr] Data última revisão:
170303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:0172002/AIM.005


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[PMID]:28193079
[Au] Autor:Ghaffarpour S; Ghazanfari T; Kabudanian Ardestani S; Pourfarzam S; Fallahi F; Shams J; Mirsharif ES; Mohseni Majd AM; Faghihzadeh S
[Ad] Endereço:1)Immunoregulation Research Center, Shahed University, Tehran, I.R. Iran.2)Department of Immunology, Shahed University, Tehran, I.R. Iran.
[Ti] Título:Correlation between MMP-9 and MMP-9/ TIMPs Complex with Pulmonary Function in Sulfur Mustard Exposed Civilians: Sardasht-Iran Cohort Study.
[So] Source:Arch Iran Med;20(2):74-82, 2017 Feb.
[Is] ISSN:1735-3947
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Matrix metalloproteinases (MMPs) are a family of proteinases and have the vigorous capacity to degrade all parts of the extracellular matrix. MMP enzymes strongly participate in physiological processes such as normal tissue remodeling and wound healing and in pathology of pulmonary diseases. They are released in response to environmental stimuli such as toxins and regulated by endogenous tissue inhibitors of metalloproteinases (TIMPs). Sulfur mustard (SM) is a chemical toxic which can cause severe permanent damages to lung tissues. The aim of this study was assessing the possible role of MMP-9 and TIMPs in SM-induced lung symptoms and signs in exposed patients 20 years after exposure. METHODS: Totally, 372 male volunteers with a history of SM- exposure and 128 age- and sex-matched unexposed controls participated and were divided into three groups: normal, mild and moderate-severe. All participants underwent clinical evaluation and pulmonary function tests and serum concentrations of MMP-9 and its inhibitors were measured using the ELISA technique. RESULTS: Serum level of MMP-9 was increased in the SM exposed group who had moderate-severe pulmonary complications compared with the SM exposed with normal lung (2.321 ± 2.836 vs. 1.546 ± 2.176, P = 0.001) while only the MMP-9/TIMP-4 complex was elevated in the SM exposed with normal lung individuals compared to its corresponding control group (85 ± 265 vs. 82 ± 222, P = 0.025). Although MMP-9 and its inhibitors did not show any correlation with spirometry findings, elevated circulating MMP-9 was detected in SM exposed patients with chronic chough and hemoptysis (P = 0.013 and P = 0.013 respectively). CONCLUSION: High level of tissue disruption and remodeling mediators could influence lung structure in long-term after SM-exposure. The correlation of clinical evaluation with these factors efficiently helps us to identify important effectors.
[Mh] Termos MeSH primário: Pneumopatias/induzido quimicamente
Metaloproteinase 9 da Matriz/sangue
Gás de Mostarda/toxicidade
Inibidores Teciduais de Metaloproteinases/sangue
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Seres Humanos
Irã (Geográfico)
Masculino
Meia-Idade
Espirometria
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tissue Inhibitor of Metalloproteinases); EC 3.4.24.35 (MMP9 protein, human); EC 3.4.24.35 (Matrix Metalloproteinase 9); T8KEC9FH9P (Mustard Gas)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170303
[Lr] Data última revisão:
170303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:0172002/AIM.003



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