| [PMID]: | 6255694 |
| [Au] Autor: | Mihály A; Pór I; Bencze G; Csillik B |
| [Ti] Título: | Effects of perineurally applied cytostatic, cytotoxic and chelating agents upon peripheral and central processes of primary nociceptive neurons. |
| [So] Source: | Z Mikrosk Anat Forsch;94(3):531-44, 1980. |
| [Is] ISSN: | 0044-3107 |
| [Cp] País de publicação: | Germany |
| [La] Idioma: | eng |
| [Ab] Resumo: | After perineural application, the effects of mannomustine, cyclophosphamide, tetrameskylmannite, 6-mercaptopurine, azathioprine and d-penicillamine upon structure of peripheral nerves and the substantia gelatinosa Rolandi were studied by means of neurohistochemical techniques and compared to those of the microtubule inhibitors Vinblastine, Vincristine and colchicine. While the cytostatic and cytotoxic drugs induced only sporadic degeneration in the structure of the peripheral nerve and, accordingly, caused only a minor extent of transganglionic degenerative atrophy in the Rolando substance, the chelating agent d-penicillamine causes massive Wallerian degeneration after perineural application and, consequently, induces an extensive degenerative atrophy in the Rolando substance. The destructive effect of d-penicillamine upon conduction properties of the impaired nerve has been established also by means of electrophysiological recording. All the drugs studied differ fundamentally from microtubule inhibitors like the Vinca alcaloids that, by virtue of their blocking effect of axoplasmic transport, induce degenerative atrophy in the Rolando substance after perineural application without causing Wallerian degeneration in the peripheral nerve. Accordingly Vinca alcaloids are the most promising candidates as locally applied therapeutics in intractable pain. |
| [Mh] Termos MeSH primário: |
Antineoplásicos/farmacologia
Quelantes/farmacologia
Neurônios/efeitos dos fármacos
Nervos Periféricos/efeitos dos fármacos
Medula Espinal/efeitos dos fármacos
Substância Gelatinosa/efeitos dos fármacos
|
| [Mh] Termos MeSH secundário: |
Potenciais de Ação/efeitos dos fármacos
Animais
Atrofia
Azatioprina/farmacologia
Ciclofosfamida/farmacologia
Feminino
Masculino
Manomustina/farmacologia
Mercaptopurina/farmacologia
Mesilatos/farmacologia
Condução Nervosa/efeitos dos fármacos
Penicilamina/farmacologia
Ratos
Nervo Isquiático/efeitos dos fármacos
Nervo Isquiático/fisiologia
Substância Gelatinosa/patologia
Degeneração Walleriana
|
| [Pt] Tipo de publicação: | JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T |
[Nm] Nome de substância:
| 0 (Antineoplastic Agents); 0 (Chelating Agents); 0 (Mesylates); 8N3DW7272P (Cyclophosphamide); E60VWA40D2 (Mannomustine); E7WED276I5 (Mercaptopurine); GNN1DV99GX (Penicillamine); MRK240IY2L (Azathioprine) |
| [Em] Mês de entrada: | 8102 |
| [Cu] Atualização por classe: | 171117 |
[Lr] Data última revisão:
| 171117 |
| [Sb] Subgrupo de revista: | IM |
| [Da] Data de entrada para processamento: | 800101 |
| [St] Status: | MEDLINE |
| |
|
