Base de dados : MEDLINE
Pesquisa : D02.455.849.291.239 [Categoria DeCS]
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  1 / 1107 MEDLINE  
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[PMID]:28641459
[Au] Autor:Song JL; Yuan Y; Nie LH; Li BL; Qin XB; Li Y; Wu JW; Qiu SX
[Ad] Endereço:a Program for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden , Chinese Academy of Sciences , Guangzhou , People's Republic of China.
[Ti] Título:A new ent-kaurane diterpene derivative from the stems of Eurya chinensis R.Br.
[So] Source:Nat Prod Res;32(2):182-188, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:One new ent-kaurane diterpene derivative (1), along with four known diterpenes, was isolated from the stems of Eurya chinensis R.Br. The structure of the new compound was established by extensive analysis of mass spectrometric and 1D and 2D NMR spectroscopic data. Compound 1 showed moderate anti-inflammatory activities with IC value of 8.12 µM. This is the first example of diterpenoids with 4-hydroxy-4-(2-hydroxyethyl)-1-hydroxyl-cyclohexanoyl substituent.
[Mh] Termos MeSH primário: Anti-Inflamatórios/isolamento & purificação
Diterpenos Caurânicos/isolamento & purificação
Caules de Planta/química
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Anti-Inflamatórios/química
Anti-Inflamatórios/farmacologia
Diterpenos/química
Diterpenos/isolamento & purificação
Diterpenos Caurânicos/química
Diterpenos Caurânicos/farmacologia
Estrutura Molecular
Análise Espectral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Diterpenes); 0 (Diterpenes, Kaurane)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1343327


  2 / 1107 MEDLINE  
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[PMID]:28778552
[Au] Autor:Nowacka M; Fijalkowska A; Wiktor A; Dadan M; Tylewicz U; Dalla Rosa M; Witrowa-Rajchert D
[Ad] Endereço:Department of Food Engineering and Process Management, Faculty of Food Sciences, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159c, 02-776 Warsaw, Poland. Electronic address: malgorzata_nowacka@sggw.pl.
[Ti] Título:Influence of power ultrasound on the main quality properties and cell viability of osmotic dehydrated cranberries.
[So] Source:Ultrasonics;83:33-41, 2018 Feb.
[Is] ISSN:1874-9968
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The aim of the study was to investigate the effect of ultrasound treatment in two osmotic solutions, carried out at different time, on some physical properties, antioxidant activity and cell survival of cranberries. Ultrasound treatment was conducted at 21kHz for 30 and 60min in liquid medium: 61.5% sucrose solution and 30% sucrose solution with 0.1% steviol glycosides addition. Some samples before the ultrasound treatment were subjected to cutting or blanching. The results showed that dry matter content and concentration of the dissolved substances increased during ultrasound treatment in osmotic solution, however higher value was observed for treatment in 61.5% sucrose solution and for longer time. Water activity and volume of cranberries did not change after the ultrasonic treatment. Combined treatment led to colour and antioxidant activity alterations as well. A cell viability of whole and cut samples decreased after 60min of osmotic treatment and completely lost in the blanched samples.
[Mh] Termos MeSH primário: Sobrevivência Celular/efeitos da radiação
Dessecação/métodos
Conservação de Alimentos/métodos
Qualidade dos Alimentos
Ondas de Choque de Alta Energia
Osmose/efeitos da radiação
Vaccinium macrocarpon/efeitos da radiação
[Mh] Termos MeSH secundário: Sobrevivência Celular/fisiologia
Diterpenos Caurânicos/química
Relação Dose-Resposta à Radiação
Análise de Alimentos
Glucosídeos/química
Dose de Radiação
Sacarose/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes, Kaurane); 0 (Glucosides); 0YON5MXJ9P (stevioside); 57-50-1 (Sucrose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170806
[St] Status:MEDLINE


  3 / 1107 MEDLINE  
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[PMID]:29303372
[Au] Autor:Shen QK; Chen ZA; Zhang HJ; Li JL; Liu CF; Gong GH; Quan ZS
[Ad] Endereço:a Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, College of Pharmacy , Yanbian University , Yanji , China.
[Ti] Título:Design and synthesis of novel oridonin analogues as potent anticancer agents.
[So] Source:J Enzyme Inhib Med Chem;33(1):324-333, 2018 Dec.
[Is] ISSN:1475-6374
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To identify anticancer agents with higher potency and lower toxicity, a series of oridonin derivatives with substituted benzene moieties at the C17 position were designed, synthesised, and evaluated for their antiproliferative properties. Most of the derivatives exhibited antiproliferative effects against AGS, MGC803, Bel7402, HCT116, A549, and HeLa cells. Compound 2p (IC = 1.05 µM) exhibited the most potent antiproliferative activity against HCT116 cells; it was more potent than oridonin (IC = 6.84 µM) and 5-fluorouracil (5-FU) (IC = 24.80 µM). The IC value of 2p in L02 cells was 6.5-fold higher than that in HCT116 cells. Overall, it exhibited better selective antiproliferative activity and specificity than oridonin and 5-FU. Furthermore, compound 2p arrested HCT116 cells at the G2 phase of the cell cycle and increased the percentage of apoptotic cells to a greater extent than oridonin.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Diterpenos Caurânicos/farmacologia
Desenho de Drogas
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Antineoplásicos/química
Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Diterpenos Caurânicos/síntese química
Diterpenos Caurânicos/química
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Conformação Molecular
Relação Estrutura-Atividade
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Diterpenes, Kaurane); 0APJ98UCLQ (oridonin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1080/14756366.2017.1419219


  4 / 1107 MEDLINE  
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[PMID]:29258552
[Au] Autor:Chavushyan VA; Simonyan KV; Simonyan RM; Isoyan AS; Simonyan GM; Babakhanyan MA; Hovhannisyian LE; Nahapetyan KH; Avetisyan LG; Simonyan MA
[Ad] Endereço:Orbeli Institute of Physiology NAS RA, 22 Orbeli Bros Street, 0028, Yerevan, Armenia.
[Ti] Título:Effects of stevia on synaptic plasticity and NADPH oxidase level of CNS in conditions of metabolic disorders caused by fructose.
[So] Source:BMC Complement Altern Med;17(1):540, 2017 Dec 19.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Excess dietary fructose intake associated with metabolic syndrome and insulin resistance and increased risk of developing type 2 diabetes. Previous animal studies have reported that diabetic animals have significantly impaired behavioural and cognitive functions, pathological synaptic function and impaired expression of glutamate receptors. Correction of the antioxidant status of laboratory rodents largely prevents the development of fructose-induced plurimetabolic changes in the nervous system. We suggest a novel concept of efficiency of Stevia leaves for treatment of central diabetic neuropathy. METHODS: By in vivo extracellular studies induced spike activity of hippocampal neurons during high frequency stimulation of entorhinal cortex, as well as neurons of basolateral amygdala to high-frequency stimulation of the hippocampus effects of Stevia rebaudiana Bertoni plant evaluated in synaptic activity in the brain of fructose-enriched diet rats. In the conditions of metabolic disorders caused by fructose, antioxidant activity of Stevia rebaudiana was assessed by measuring the NOX activity of the hippocampus, amygdala and spinal cord. RESULTS: In this study, the characteristic features of the metabolic effects of dietary fructose on synaptic plasticity in hippocampal neurons and basolateral amygdala and the state of the NADPH oxidase (NOX) oxidative system of these brain formations are revealed, as well as the prospects for development of multitarget and polyfunctional phytopreparations (with adaptogenic, antioxidant, antidiabetic, nootropic activity) from native raw material of Stevia rebaudiana. Stevia modulates degree of expressiveness of potentiation/depression (approaches but fails to achieve the norm) by shifting the percentage balance in favor of depressor type of responses during high-frequency stimulation, indicating its adaptogenic role in plasticity of neural networks. Under the action of fructose an increase (3-5 times) in specific quantity of total fraction of NOX isoforms isolated from the central nervous system tissue (amygdala, hippocampus, spinal cord) was revealed. Stevia exhibits an antistress, membrane-stabilizing role reducing the level of total fractions of NOX isoforms from central nervous system tissues and regulates NADPH-dependent O -producing activity. CONCLUSION: Generally, in condition of metabolic disorders caused by intensive consumption of dietary fructose Stevia leaves contributes to the control of neuronal synaptic plasticity possibly influencing the conjugated NOX-specific targets.
[Mh] Termos MeSH primário: Química Encefálica/efeitos dos fármacos
Encéfalo/efeitos dos fármacos
Diterpenos Caurânicos/farmacologia
Frutose/efeitos adversos
Glucosídeos/farmacologia
NADPH Oxidases/análise
Plasticidade Neuronal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Potenciais de Ação/efeitos dos fármacos
Animais
Encéfalo/citologia
Encéfalo/enzimologia
Açúcares da Dieta/efeitos adversos
Masculino
Doenças Metabólicas/induzido quimicamente
Doenças Metabólicas/metabolismo
NADPH Oxidases/metabolismo
Ratos
Stevia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Sugars); 0 (Diterpenes, Kaurane); 0 (Glucosides); 0YON5MXJ9P (stevioside); 30237-26-4 (Fructose); EC 1.6.3.- (NADPH Oxidases)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2049-9


  5 / 1107 MEDLINE  
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[PMID]:28901767
[Au] Autor:Xu S; Yao H; Hu M; Li D; Zhu Z; Xie W; Yao H; Wu L; Chen ZS; Xu J
[Ad] Endereço:State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University , Nanjing 210009, People's Republic of China.
[Ti] Título:6,7-Seco-ent-Kauranoids Derived from Oridonin as Potential Anticancer Agents.
[So] Source:J Nat Prod;80(9):2391-2398, 2017 Sep 22.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Structurally unique 6,7-seco-ent-kaurenes, which are widely distributed in the genus Isodon, have attracted considerable attention because of their antitumor activities. Previously, a convenient conversion of commercially available oridonin (1) to 6,7-seco-ent-kaurenes was developed. Herein, several novel spiro-lactone-type ent-kaurene derivatives bearing various substituents at the C-1 and C-14 positions were further designed and synthesized from the natural product oridonin. Moreover, a number of seven-membered C-ring-expanded 6,7-seco-ent-kaurenes were also identified for the first time. It was observed that most of the spiro-lactone-type ent-kaurenes tested markedly inhibited the proliferation of cancer cells, with an IC value as low as 0.55 µM. An investigation on its mechanism of action showed that the representative compound 7b affected the cell cycle and induced apoptosis at a low micromolar level in MCF-7 human breast cancer cells. Furthermore, compound 7b inhibited liver tumor growth in an in vivo mouse model and exhibited no observable toxic effects. Collectively, the results warrant further preclinical investigations of these spiro-lactone-type ent-kaurenes as potential novel anticancer agents.
[Mh] Termos MeSH primário: Antineoplásicos/isolamento & purificação
Apoptose/efeitos dos fármacos
Neoplasias da Mama/tratamento farmacológico
Diterpenos Caurânicos/isolamento & purificação
Diterpenos Caurânicos/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/química
Antineoplásicos/farmacologia
Linhagem Celular Tumoral
Diterpenos Caurânicos/química
Seres Humanos
Células MCF-7
Camundongos
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Diterpenes, Kaurane); 0APJ98UCLQ (oridonin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00057


  6 / 1107 MEDLINE  
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[PMID]:28869908
[Au] Autor:Zhang YY; Jiang HY; Liu M; Hu K; Wang WG; Du X; Li XN; Pu JX; Sun HD
[Ad] Endereço:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 10039, People's Republic of China; Yunnan Key Laboratory of Natural Med
[Ti] Título:Bioactive ent-kaurane diterpenoids from Isodon rubescens.
[So] Source:Phytochemistry;143:199-207, 2017 Nov.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Seven previously undescribed 7,20-epoxy-ent-kaurane diterpenoids, isojiangrubesins A-G, along with seventeen known ones, were isolated from the aerial parts of Isodon rubescens. Their structures were characterized on the basis of spectroscopic methods and signal-crystal X-ray diffraction. All of these compounds were evaluated for their in vitro cytotoxicity against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480). Four isolates exhibited significant inhibitory ability against all cell lines, with IC values ranging from 0.5 to 6.5 µM; They also strongly inhibited NO production in LPS-stimulated RAW264.7 cells.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Diterpenos Caurânicos/isolamento & purificação
Diterpenos Caurânicos/farmacologia
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/farmacologia
Isodon/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Cristalografia por Raios X
Diterpenos Caurânicos/química
Ensaios de Seleção de Medicamentos Antitumorais
Medicamentos de Ervas Chinesas/química
Células HL-60
Seres Humanos
Lipopolissacarídeos/farmacologia
Macrófagos/efeitos dos fármacos
Estrutura Molecular
Óxido Nítrico/biossíntese
Componentes Aéreos da Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Diterpenes, Kaurane); 0 (Drugs, Chinese Herbal); 0 (Lipopolysaccharides); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE


  7 / 1107 MEDLINE  
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[PMID]:28801140
[Au] Autor:Che Y; Wang J; Yuan Z; Li Y; Lu Z; Zhang Z; Zhang J; Wan J; Sun H; Chen Z; Pu J; He J
[Ad] Endereço:Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Electronic address: cheyun47@yeah.net.
[Ti] Título:TEMPORARY REMOVAL: The therapeutic effects of Longikaurin A, a natural ent-kauranoid, in esophageal squamous cell carcinoma depend on ROS accumulation and JNK/p38 MAPK activation.
[So] Source:Toxicol Lett;280:106-115, 2017 10 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/metabolismo
Diterpenos Caurânicos/farmacologia
Neoplasias Esofágicas/metabolismo
Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/farmacologia
Carcinoma de Células Escamosas/genética
Ativação Enzimática/efeitos dos fármacos
Neoplasias Esofágicas/genética
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Proteínas Quinases JNK Ativadas por Mitógeno/genética
Proteínas Quinases p38 Ativadas por Mitógeno/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Diterpenes, Kaurane); 0 (Reactive Oxygen Species); 0 (longikaurin A); EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE


  8 / 1107 MEDLINE  
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[PMID]:28783337
[Au] Autor:Gobu FR; Chen JJ; Zeng J; Wei WJ; Wang WF; Lin CJ; Gao K
[Ad] Endereço:State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, and ‡School of Life Sciences, Lanzhou University , Lanzhou 730000, People's Republic of China.
[Ti] Título:Isolation, Structure Elucidition, and Immunosuppressive Activity of Diterpenoids from Ligularia fischeri.
[So] Source:J Nat Prod;80(8):2263-2268, 2017 Aug 25.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Six new (1-3 and 6-8) and seven known diterpenoids were isolated from the whole plant of Ligularia fischeri. Compound 1 is a new 15,16-dinorerythroxylane-type diterpenoid possessing a C skeleton, and 2 is the first example of a 6/6/6/6/5/5-fused hexacyclic ent-kaurane diterpenoid with 19,20-olide and 11,16-epoxy moieties. The structures of the new compounds were elucidated by spectroscopic analysis and chemical methods. The absolute configurations of 1 and 7 were determined by single-crystal X-ray diffraction. Compounds 1-13 were evaluated for their immunosuppressive activity, and 4, 7, and 13 showed moderate inhibitory activities against human B lymphoblast HMy2.CIR cells with IC values of 56.3 ± 2.2, 13.3 ± 0.8, and 31.4 ± 0.9 µM, respectively.
[Mh] Termos MeSH primário: Asteraceae/química
Diterpenos Caurânicos/isolamento & purificação
Diterpenos Caurânicos/farmacologia
Diterpenos/isolamento & purificação
Diterpenos/farmacologia
Imunossupressores/isolamento & purificação
Imunossupressores/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Diterpenos/química
Diterpenos Caurânicos/química
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Concentração Inibidora 50
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (15,16-dinorerythroxylane); 0 (Antineoplastic Agents, Phytogenic); 0 (Diterpenes); 0 (Diterpenes, Kaurane); 0 (Immunosuppressive Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00198


  9 / 1107 MEDLINE  
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[PMID]:28654256
[Au] Autor:Jiang HY; Wang WG; Tang JW; Liu M; Li XR; Hu K; Du X; Li XN; Zhang HB; Pu JX; Sun HD
[Ad] Endereço:State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
[Ti] Título:Structurally Diverse Diterpenoids from Isodon scoparius and Their Bioactivity.
[So] Source:J Nat Prod;80(7):2026-2036, 2017 Jul 28.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fourteen new diterpenoids (1-14) based on four skeletal types and two known analogues (15 and 16) were isolated from the aerial parts of Isodon scoparius. Compound 2 is the first ent-kaurane diterpenoid featuring a 1,11-ether bridge, and the structures of these new compounds were established mainly by NMR and MS methods. The absolute configurations of 1 and 5 and the relative configuration of 3 were determined using single-crystal X-ray diffraction. The absolute configuration of 14 was determined by comparison of the experimental and calculated electronic circular dichroism spectra. Compounds 1, 4, and 15 were active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and they also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC values of 1.0, 3.1, and 1.8 µM, respectively.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos
Diterpenos Caurânicos
Isodon/química
Componentes Aéreos da Planta/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Cristalografia por Raios X
Diterpenos Caurânicos/química
Diterpenos Caurânicos/isolamento & purificação
Diterpenos Caurânicos/farmacologia
Ensaios de Seleção de Medicamentos Antitumorais
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/farmacologia
Células HL-60
Seres Humanos
Lipopolissacarídeos/farmacologia
Macrófagos/efeitos dos fármacos
Estrutura Molecular
Óxido Nítrico/biossíntese
Ressonância Magnética Nuclear Biomolecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Diterpenes, Kaurane); 0 (Drugs, Chinese Herbal); 0 (Lipopolysaccharides); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00163


  10 / 1107 MEDLINE  
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[PMID]:28618955
[Au] Autor:Wang XH; Zhang SF; Bao JT; Liu FY
[Ad] Endereço:1 Department of Pediatric Orthopedics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
[Ti] Título:Oridonin synergizes with Nutlin-3 in osteosarcoma cells by modulating the levels of multiple Bcl-2 family proteins.
[So] Source:Tumour Biol;39(6):1010428317701638, 2017 Jun.
[Is] ISSN:1423-0380
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The small-molecule inhibitors of p53-murine double minute 2 interaction, such as Nutlin-3, are effective against cancers bearing wild-type p53. However, murine double minute 2 inhibitors often are unable to completely eliminate solid tumor cells. To address this issue, we investigated the anticancer effects of Nutlin-3 in combination with Oridonin in osteosarcoma cells. We found that Oridonin at sub-toxic concentrations synergistically enhanced Nutlin-3-mediated cell viability inhibition in wild-type p53 U2OS and SJSA-1, but not in p53-mutant MNNG/HOS and in null-p53 Saos-2 osteosarcoma cell lines. Importantly, in the presence of Oridonin, Nutlin-3 could completely abolish cell viability in the wild-type p53 osteosarcoma cell lines. Western blotting analysis showed that Oridonin treatment rapidly and distinctly increased the levels of all three forms of Bim and also markedly reduced the levels of Bcl-2 and Bcl-xl in osteosarcoma cells. Western blotting analysis further showed that Oridonin considerably enhanced Nutlin-3-triggered activation of caspases-9 and -3 and poly(ADP-ribose) polymerase cleavage. Flow cytometry assay showed that Oridonin significantly enhanced Nutlin-3-mediated apoptosis in wild-type p53 osteosarcoma cells. Overall, our results suggest that the combined treatment of Nutlin-3 plus Oridonin may offer a novel therapeutic strategy for osteosarcoma.
[Mh] Termos MeSH primário: Diterpenos Caurânicos/administração & dosagem
Imidazóis/administração & dosagem
Osteossarcoma/tratamento farmacológico
Piperazinas/administração & dosagem
Proteínas Proto-Oncogênicas c-bcl-2/genética
Proteína Supressora de Tumor p53/genética
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Proteína 11 Semelhante a Bcl-2/genética
Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Sinergismo Farmacológico
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Osteossarcoma/genética
Osteossarcoma/patologia
Proteínas Proto-Oncogênicas c-mdm2/antagonistas & inibidores
Proteínas Proto-Oncogênicas c-mdm2/genética
Proteína bcl-X/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (BCL2L1 protein, human); 0 (Bcl-2-Like Protein 11); 0 (Diterpenes, Kaurane); 0 (Imidazoles); 0 (Piperazines); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (Tumor Suppressor Protein p53); 0 (bcl-X Protein); 0APJ98UCLQ (oridonin); 53IA0V845C (nutlin 3); EC 2.3.2.27 (MDM2 protein, human); EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE
[do] DOI:10.1177/1010428317701638



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