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Pesquisa : D02.455.849.291.523 [Categoria DeCS]
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  1 / 221 MEDLINE  
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[PMID]:28654264
[Au] Autor:Yang K; Wang L; Zhou G; Lin X; Peng J; Wang L; Luo L; Wang J; Shu G; Wang S; Gao P; Zhu X; Xi Q; Zhang Y; Jiang Q
[Ad] Endereço:College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University , Guangzhou, Guangdong 510640, People's Republic of China.
[Ti] Título:Phytol Promotes the Formation of Slow-Twitch Muscle Fibers through PGC-1α/miRNA but Not Mitochondria Oxidation.
[So] Source:J Agric Food Chem;65(29):5916-5925, 2017 Jul 26.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Phytol is a side chain of chlorophyll belonging to the side-chain double terpenoid. When animals consume food rich in chlorophyll, phytol can be broken down to phytanic acid after digestion. It was reported that feeding animals with different varieties and levels of forage could significant improve pH and marbling score of steer and lamb carcasses, but the internal mechanism for this is still not reported. The marbling score and pH of muscle was mainly determined by skeletal muscle fiber type, which is due to expression of different myosin heavy-chain (MHC) isoforms. Here, we provide evidence that phytol can indeed affect the diversity of muscle fiber types both in vitro and in vivo and demonstrate that phytol can increase the expression of MHC I (p < 0.05), likely by upgrading the expression of PPARδ, PGC-1α, and related miRNAs. This fiber-type transformation process may not be caused by activated mitochondrial metabolism but by the structural changes in muscle fiber types.
[Mh] Termos MeSH primário: MicroRNAs/metabolismo
Mitocôndrias/metabolismo
Fibras Musculares de Contração Lenta/metabolismo
Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo
Fitol/metabolismo
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Masculino
Camundongos
MicroRNAs/genética
Mitocôndrias/genética
Fibras Musculares Esqueléticas/metabolismo
Oxirredução
Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MicroRNAs); 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha); 0 (Ppargc1a protein, mouse); 150-86-7 (Phytol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b01048


  2 / 221 MEDLINE  
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[PMID]:28629946
[Au] Autor:Mezzar S; De Schryver E; Asselberghs S; Meyhi E; Morvay PL; Baes M; Van Veldhoven PP
[Ad] Endereço:LIPIT, Department of Cellular and Molecular Medicine, KU Leuven, Belgium.
[Ti] Título:Phytol-induced pathology in 2-hydroxyacyl-CoA lyase (HACL1) deficient mice. Evidence for a second non-HACL1-related lyase.
[So] Source:Biochim Biophys Acta;1862(9):972-990, 2017 09.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:2-Hydroxyacyl-CoA lyase (HACL1) is a key enzyme of the peroxisomal α-oxidation of phytanic acid. To better understand its role in health and disease, a mouse model lacking HACL1 was investigated. Under normal conditions, these mice did not display a particular phenotype. However, upon dietary administration of phytol, phytanic acid accumulated in tissues, mainly in liver and serum of KO mice. As a consequence of phytanic acid (or a metabolite) toxicity, KO mice displayed a significant weight loss, absence of abdominal white adipose tissue, enlarged and mottled liver and reduced hepatic glycogen and triglycerides. In addition, hepatic PPARα was activated. The central nervous system of the phytol-treated mice was apparently not affected. In addition, 2OH-FA did not accumulate in the central nervous system of HACL1 deficient mice, likely due to the presence in the endoplasmic reticulum of an alternate HACL1-unrelated lyase. The latter may serve as a backup system in certain tissues and account for the formation of pristanic acid in the phytol-fed KO mice. As the degradation of pristanic acid is also impaired, both phytanoyl- and pristanoyl-CoA levels are increased in liver, and the ω-oxidized metabolites are excreted in urine. In conclusion, HACL1 deficiency is not associated with a severe phenotype, but in combination with phytanic acid intake, the normal situation in man, it might present with phytanic acid elevation and resemble a Refsum like disorder.
[Mh] Termos MeSH primário: Enoil-CoA Hidratase/deficiência
Enoil-CoA Hidratase/metabolismo
Liases/metabolismo
Fitol/farmacologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Retículo Endoplasmático/efeitos dos fármacos
Retículo Endoplasmático/metabolismo
Ácidos Graxos/farmacologia
Feminino
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Camundongos
Camundongos Knockout
Oxirredução
PPAR alfa/metabolismo
Ácido Fitânico/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fatty Acids); 0 (PPAR alpha); 14721-66-5 (Phytanic Acid); 150-86-7 (Phytol); 5FMQ2908AP (pristanic acid); EC 4.- (Lyases); EC 4.2.1.17 (Enoyl-CoA Hydratase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE


  3 / 221 MEDLINE  
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[PMID]:28571740
[Au] Autor:Wang J; Hu X; Ai W; Zhang F; Yang K; Wang L; Zhu X; Gao P; Shu G; Jiang Q; Wang S
[Ad] Endereço:Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, PR China; National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, PR China.
[Ti] Título:Phytol increases adipocyte number and glucose tolerance through activation of PI3K/Akt signaling pathway in mice fed high-fat and high-fructose diet.
[So] Source:Biochem Biophys Res Commun;489(4):432-438, 2017 Aug 05.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It has been shown that adipose tissue hyperplasia (increased adipocyte number or adipogenesis) has beneficial effects on metabolic health. The aim of the present study was to determine whether phytol could modulate hyperplasia/adipogenesis and glucose homeostasis, and to explore the underlying mechanisms in mice fed high-fat and high fructose diet (HFFD). Our results demonstrated that phytol administration decreased body weight gain and inguinal subcutaneous white adipose tissue (iWAT) weight. However, phytol significantly increased the adipocyte number in iWAT, with the smaller average adipocyte diameter. Meanwhile, OGTT result showed that phytol improved glucose tolerance. In accord, phytol administration markedly increased expression of marker genes associated with adipogenesis (PPARγ and C/EBPα) and glucose uptake (AS160 and GLUT4) and activated PI3K/Akt signaling pathway in mice iWAT. In agreement with the in vivo findings, the in vitro results indicated that 100 µM phytol significantly enhanced 3T3-L1 adipogenesis and glucose uptake, and activated PI3K/Akt signaling pathway. However, phytol-induced enhancement of 3T3-L1 adipognesis and glucose uptake, activation of PI3K/Akt signaling pathway, elevation of marker genes involved in adipogensis and glucose uptake, as well as translocation of GLUT4 from cytoplasm to membrane were abolished by Wortmannin, a specific PI3K/Akt inhibitor. Taken together, phytol increased adipocyte number in iWAT and improved glucose tolerance in mice fed HFFD, which was coincident with the enhanced adipogenesis and glucose uptake in 3T3-L1, and was associated with activation of PI3K/Akt signaling pathway. These data suggested the application of phytol as a potential nutritional agent to combat obesity and type 2 diabetes.
[Mh] Termos MeSH primário: Adipócitos/efeitos dos fármacos
Dieta Hiperlipídica
Frutose/administração & dosagem
Fosfatidilinositol 3-Quinases/metabolismo
Fitol/farmacologia
Proteínas Proto-Oncogênicas c-akt/metabolismo
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Células 3T3-L1
Adipócitos/citologia
Androstadienos/farmacologia
Animais
Contagem de Células
Diferenciação Celular/efeitos dos fármacos
Células Cultivadas
Diabetes Mellitus Experimental
Dieta da Carga de Carboidratos/efeitos adversos
Dieta Hiperlipídica/efeitos adversos
Frutose/efeitos adversos
Teste de Tolerância a Glucose
Camundongos
Camundongos Endogâmicos C57BL
Fosfatidilinositol 3-Quinases/antagonistas & inibidores
Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androstadienes); 150-86-7 (Phytol); 30237-26-4 (Fructose); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); XVA4O219QW (wortmannin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE


  4 / 221 MEDLINE  
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[PMID]:28284120
[Au] Autor:Islam MT; Streck L; de Alencar MV; Cardoso Silva SW; da Conceição Machado K; da Conceição Machado K; Gomes Júnior AL; Paz MF; da Mata AM; de Castro E Sousa JM; da Costa Junior JS; Lins Rolim HM; da Silva-Junior AA; de Carvalho Melo-Cavalcante AA
[Ad] Endereço:Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, PI, 64.049-550, Brazil; Department of Pharmacy, Southern University Bangladesh, Mehedibag, Chittagong, 4000, Bangladesh. Electronic address: rbiotufpi.br@gmail.com.
[Ti] Título:Evaluation of toxic, cytotoxic and genotoxic effects of phytol and its nanoemulsion.
[So] Source:Chemosphere;177:93-101, 2017 Jun.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytol (PYT) is a diterpenoid having important biological activity. However, it is a water non-soluble compound. This study aims to prepare PYT nanoemulsion (PNE) and evaluation of toxic, cytotoxic and genotoxic activities of PYT and PNE. For this, the PNE was prepared by the phase inversion method. The cytotoxicity test was performed in Artemia salina, while toxicity, cytotoxicity and genotoxicity in Allium cepa at concentrations of 2, 4, 8 and 16 mM. Potassium dichromate and copper sulfate were used as positive controls for the tests of A. salina and A. cepa, respectively. In addition, an adaptation response was detected in A. cepa by using the comet assay. The results suggest that both PYT and PNE exhibited toxic and cytotoxic effects at 4-16 mM in either test system, while genotoxicity at 2-16 mM in A. cepa. PNE exhibited more toxic, cytotoxic and genotoxic effects at 8 and 16 mM than the PYT. However, both PYT and PNE at 2 and 4 mM decreased the index and frequency of damage in A. cepa after 48 and 72 h, suggesting a possible adaptation response or DNA damage preventing capacity. Nanoemulsified PYT (PNE) may readily cross the biological membranes with an increase in bioavailability and produce more toxic, cytotoxic and genotoxic effects in the used test systems.
[Mh] Termos MeSH primário: Artemia/crescimento & desenvolvimento
Dano ao DNA/efeitos dos fármacos
Nanopartículas/toxicidade
Cebolas/citologia
Fitol/toxicidade
[Mh] Termos MeSH secundário: Animais
Artemia/efeitos dos fármacos
Ensaio Cometa
Emulsões/química
Emulsões/toxicidade
Nanopartículas/química
Cebolas/efeitos dos fármacos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Emulsions); 150-86-7 (Phytol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE


  5 / 221 MEDLINE  
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[PMID]:28254487
[Au] Autor:Montagut-Romans A; Boulven M; Jacolot M; Moebs-Sanchez S; Hascoët C; Hammed A; Besse S; Lemaire M; Benoit E; Lattard V; Popowycz F
[Ad] Endereço:Univ Lyon, Université Claude Bernard Lyon 1, Laboratoire de Catalyse, Synthèse et Environnement, Institut de Chimie et de Biochimie Moléculaires et Supramoléculaires, ICBMS-CNRS-UMR 5246, F-69622 Villeurbanne Cedex, France; USC 1233 RS2GP, VetAgro Sup, INRA, Univ Lyon, F-69280 Marcy l'Etoile, France
[Ti] Título:Synthesis and biological evaluation of C-3 aliphatic coumarins as vitamin K antagonists.
[So] Source:Bioorg Med Chem Lett;27(7):1598-1601, 2017 04 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Since the discovery of Warfarin in the 1940s, the design of new warfarin-derived anticoagulants for rodent management has been challenging, with mainly structural modifications performed on the C3 position of the coumarin skeleton. In order to better understand the pharmacomodulation of such derivatives, we have synthesized a family of C3 (linear and branched) alkyl-4-hydroxycoumarins, which led to the identification of compounds 5e and 5f as potential short-term active anticoagulants.
[Mh] Termos MeSH primário: 4-Hidroxicumarinas/farmacologia
Anticoagulantes/farmacologia
Vitamina K Epóxido Redutases/antagonistas & inibidores
Vitamina K/antagonistas & inibidores
[Mh] Termos MeSH secundário: 4-Hidroxicumarinas/administração & dosagem
4-Hidroxicumarinas/síntese química
Animais
Anticoagulantes/administração & dosagem
Anticoagulantes/síntese química
Masculino
Microssomos Hepáticos/efeitos dos fármacos
Microssomos Hepáticos/metabolismo
Fitol/administração & dosagem
Fitol/análogos & derivados
Fitol/síntese química
Fitol/farmacologia
Tempo de Protrombina
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4-Hydroxycoumarins); 0 (Anticoagulants); 12001-79-5 (Vitamin K); 150-86-7 (Phytol); EC 1.17.4.4 (VKORC1 protein, rat); EC 1.17.4.4 (Vitamin K Epoxide Reductases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE


  6 / 221 MEDLINE  
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[PMID]:28042698
[Au] Autor:Tang T; Mohr W; Sattin SR; Rogers DR; Girguis PR; Pearson A
[Ad] Endereço:Department of Earth and Planetary Sciences, Harvard University, Cambridge, MA, USA.
[Ti] Título:Geochemically distinct carbon isotope distributions in Allochromatium vinosum DSM 180 grown photoautotrophically and photoheterotrophically.
[So] Source:Geobiology;15(2):324-339, 2017 Mar.
[Is] ISSN:1472-4669
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Anoxygenic, photosynthetic bacteria are common at redox boundaries. They are of interest in microbial ecology and geosciences through their role in linking the carbon, sulfur, and iron cycles, yet much remains unknown about how their flexible carbon metabolism-permitting either autotrophic or heterotrophic growth-is recorded in the bulk sedimentary and lipid biomarker records. Here, we investigated patterns of carbon isotope fractionation in a model photosynthetic sulfur-oxidizing bacterium, Allochromatium vinosum DSM180 . In one treatment, A. vinosum was grown with CO as the sole carbon source, while in a second treatment, it was grown on acetate. Different intracellular isotope patterns were observed for fatty acids, phytol, individual amino acids, intact proteins, and total RNA between the two experiments. Photoautotrophic CO fixation yielded typical isotopic ordering for the lipid biomarkers: δ C values of phytol > n-alkyl lipids. In contrast, growth on acetate greatly suppressed intracellular isotopic heterogeneity across all molecular classes, except for a marked C-depletion in phytol. This caused isotopic "inversion" in the lipids (δ C values of phytol < n-alkyl lipids). The finding suggests that inverse δ C patterns of n-alkanes and pristane/phytane in the geologic record may be at least in part a signal for photoheterotrophy. In both experimental scenarios, the relative isotope distributions could be predicted from an isotope flux-balance model, demonstrating that microbial carbon metabolisms can be interrogated by combining compound-specific stable isotope analysis with metabolic modeling. Isotopic differences among molecular classes may be a means of fingerprinting microbial carbon metabolism, both in the modern environment and the geologic record.
[Mh] Termos MeSH primário: Isótopos de Carbono/análise
Chromatiaceae/química
Chromatiaceae/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Acetatos/metabolismo
Aminoácidos/análise
Ciclo do Carbono
Dióxido de Carbono/metabolismo
Chromatiaceae/metabolismo
Ácidos Graxos/análise
Fitol/análise
Proteínas/análise
RNA Bacteriano/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Amino Acids); 0 (Carbon Isotopes); 0 (Fatty Acids); 0 (Proteins); 0 (RNA, Bacterial); 142M471B3J (Carbon Dioxide); 150-86-7 (Phytol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170103
[St] Status:MEDLINE
[do] DOI:10.1111/gbi.12221


  7 / 221 MEDLINE  
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[PMID]:28007557
[Au] Autor:Wang L; Li Q; Zhang A; Zhou W; Jiang R; Yang Z; Yang H; Qin X; Ding S; Lu Q; Wen X; Lu C
[Ad] Endereço:Photosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China; University of Chinese Academy of Sciences, Beijing 100049, China.
[Ti] Título:The Phytol Phosphorylation Pathway Is Essential for the Biosynthesis of Phylloquinone, which Is Required for Photosystem I Stability in Arabidopsis.
[So] Source:Mol Plant;10(1):183-196, 2017 Jan 09.
[Is] ISSN:1752-9867
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytyl-diphosphate, which provides phytyl moieties as a common substrate in both tocopherol and phylloquinone biosynthesis, derives from de novo isoprenoid biosynthesis or a salvage pathway via phytol phosphorylation. However, very little is known about the role and origin of the phytyl moiety for phylloquinone biosynthesis. Since VTE6, a phytyl-phosphate kinase, is a key enzyme for phytol phosphorylation, we characterized Arabidopsis vte6 mutants to gain insight into the roles of phytyl moieties in phylloquinone biosynthesis and of phylloquinone in photosystem I (PSI) biogenesis. The VTE6 knockout mutants vte6-1 and vte6-2 lacked detectable phylloquinone, whereas the phylloquinone content in the VTE6 knockdown mutant vte6-3 was 90% lower than that in wild-type. In vte6 mutants, PSI function was impaired and accumulation of the PSI complex was defective. The PSI core subunits PsaA/B were efficiently synthesized and assembled into the PSI complex in vte6-3. However, the degradation rate of PSI subunits in the assembled PSI complex was more rapid in vte6-3 than in wild-type. In vte6-3, PSI was more susceptible to high-light damage than in wild-type. Our results provide the first genetic evidence that the phytol phosphorylation pathway is essential for phylloquinone biosynthesis, and that phylloquinone is required for PSI complex stability.
[Mh] Termos MeSH primário: Arabidopsis/metabolismo
Complexo de Proteína do Fotossistema I/metabolismo
Fitol/metabolismo
Vitamina K 1/metabolismo
[Mh] Termos MeSH secundário: Arabidopsis/genética
Proteínas de Arabidopsis/genética
Proteínas de Arabidopsis/metabolismo
Técnicas de Inativação de Genes
Luz
Mutação
Fosforilação
Fosfotransferases (Aceptor do Grupo Álcool)/genética
Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo
Complexo de Proteína do Fotossistema I/efeitos da radiação
Estabilidade Proteica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arabidopsis Proteins); 0 (Photosystem I Protein Complex); 150-86-7 (Phytol); 84-80-0 (Vitamin K 1); EC 2.7.1.- (Phosphotransferases (Alcohol Group Acceptor)); EC 2.7.1.- (VTE6 protein, Arabidopsis)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161224
[St] Status:MEDLINE


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[PMID]:27940000
[Au] Autor:Milligan S; Martin GG; Landrock D; McIntosh AL; Mackie JT; Schroeder F; Kier AB
[Ad] Endereço:Department of Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX 77843-4467, USA.
[Ti] Título:Impact of dietary phytol on lipid metabolism in SCP2/SCPX/L-FABP null mice.
[So] Source:Biochim Biophys Acta;1862(3):291-304, 2017 03.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In vitro studies suggest that liver fatty acid binding protein (L-FABP) and sterol carrier protein-2/sterol carrier protein-x (SCP2/SCPx) gene products facilitate uptake and metabolism and detoxification of dietary-derived phytol in mammals. However, concomitant upregulation of L-FABP in SCP2/SCPx null mice complicates interpretation of their physiological phenotype. Therefore, the impact of ablating both the L-FABP gene and SCP2/SCPx gene (L-FABP/SCP2/SCPx null or TKO) was examined in phytol-fed female wild-type (WT) and TKO mice. TKO increased hepatic total lipid accumulation, primarily phospholipid, by mechanisms involving increased hepatic levels of proteins in the phospholipid synthetic pathway. Concomitantly, TKO reduced expression of proteins in targeting fatty acids towards the triacylglycerol synthetic pathway. Increased hepatic lipid accumulation was not associated with any concomitant upregulation of membrane fatty acid transport/translocase proteins involved in fatty acid uptake (FATP2, FATP4, FATP5 or GOT) or cytosolic proteins involved in fatty acid intracellular targeting (ACBP). In addition, TKO exacerbated dietary phytol-induced whole body weight loss, especially lean tissue mass. Since individually ablating SCPx or SCP2/SCPx elicited concomitant upregulation of L-FABP, these findings with TKO mice help to resolve the contributions of SCP2/SCPx gene ablation on dietary phytol-induced whole body and hepatic lipid phenotype independent of concomitant upregulation of L-FABP.
[Mh] Termos MeSH primário: Proteínas de Transporte/metabolismo
Proteínas de Ligação a Ácido Graxo/metabolismo
Metabolismo dos Lipídeos/efeitos dos fármacos
Fitol/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Dieta/métodos
Ácidos Graxos/metabolismo
Feminino
Lipídeos/fisiologia
Fígado/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Fosfolipídeos/metabolismo
Triglicerídeos/metabolismo
Regulação para Cima/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (Fabp1 protein, mouse); 0 (Fatty Acid-Binding Proteins); 0 (Fatty Acids); 0 (Lipids); 0 (Phospholipids); 0 (Triglycerides); 0 (sterol carrier proteins); 150-86-7 (Phytol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


  9 / 221 MEDLINE  
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[PMID]:27719914
[Au] Autor:Baqueiro-Peña I; Guerrero-Beltrán JÁ
[Ad] Endereço:Departamento de Ingeniería Química, Alimentos y Ambiental, Universidad de las Américas Puebla, Cholula, Puebla 72810, Mexico.
[Ti] Título:Physicochemical and antioxidant characterization of Justicia spicigera.
[So] Source:Food Chem;218:305-312, 2017 Mar 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Extracts with water:ethanol (100:0, 70:30, 50:50, 30:70, 0:100) solutions from fresh (F), just dried (JD), dried and stored for one year (DS) Justicia spicigera leaves were obtained using the stirring and ultrasound techniques. Extracts were analyzed in physicochemical and antioxidant characteristics. Identification of chemical compounds by gas chromatography-mass spectroscopy (GC-MS) was also performed. 2.14±0.91, 5.67±1.70, and 8.52±4.97g Gallic acid equivalents/100g dry weight (d.w.) of phenolic compounds were found, in average, for F, JD, and DS J. spicigera, respectively. 2.22±1.31, 2.58±2.11, and 8.48±3.78g Trolox equivalents/100g d.w. were detected with the ABTS method and 0.49±0.33, 1.23±0.87, and 0.88±0.94g with the DPPH method for F, JD and DS J. spicigera, respectively. Eucalyptol, phytol, and azulene were identified as the main compounds. J. spicigera showed colors (green-iridescent, green-yellow, or pink of different intensities) and antioxidant characteristics depending on the solvent concentration. Extracts could be used in the food and pharmaceutical industries.
[Mh] Termos MeSH primário: Antioxidantes/análise
Fenômenos Químicos
Justicia/química
[Mh] Termos MeSH secundário: Azulenos/análise
Cromanos/análise
Cor
Cicloexanóis/análise
Ácido Gálico/análise
Cromatografia Gasosa-Espectrometria de Massas
Monoterpenos/análise
Fenóis/análise
Fitol/análise
Extratos Vegetais/análise
Extratos Vegetais/farmacologia
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Azulenes); 0 (Chromans); 0 (Cyclohexanols); 0 (Monoterpenes); 0 (Phenols); 0 (Plant Extracts); 150-86-7 (Phytol); 632XD903SP (Gallic Acid); 82R6M9MGLP (azulene); RV6J6604TK (eucalyptol); S18UL9710X (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE


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[PMID]:27744691
[Au] Autor:Cantrell CL; Jones AM; Ali A
[Ad] Endereço:Natural Products Utilization Research Unit, U.S. Department of Agriculture, Agricultural Research Service , University, Mississippi 38677, United States.
[Ti] Título:Isolation and Identification of Mosquito (Aedes aegypti) Biting-Deterrent Compounds from the Native American Ethnobotanical Remedy Plant Hierochloë odorata (Sweetgrass).
[So] Source:J Agric Food Chem;64(44):8352-8358, 2016 Nov 09.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hierochloë odorata (L.) P. Beauv. (Poaceae), commonly known as sweetgrass, has documented use as an insect repellent by the Flatheads of Montana and Blackfoot of Alberta. Both the Flatheads of Montana and Blackfoot of Alberta would use braided plant material in a sachet in clothing or burn them from one end as incense, air/clothing freshener, and insect repellent. This study evaluated the insect-repellent properties of this plant using an in vitro mosquito Aedes aegypti feeding bioassay-directed approach to identify the compound(s) responsible for the observed activities. Evaluation of crude extracts produced from H. odorata revealed that the hydrodistillate had the highest level of mosquito biting deterrence. Fractionation of this extract, followed by re-evaluation for mosquito biting deterrence, produced many active fractions, which were evaluated by spectroscopic techniques and determined to contain phytol, coumarin, and 2-methoxy-4-vinylphenol. Phytol and coumarin were both determined to be responsible for the Ae. aegypti biting deterrency. Scientific evidence reported here validates its traditional use as a biting-insect deterrent.
[Mh] Termos MeSH primário: Aedes/efeitos dos fármacos
Repelentes de Insetos/isolamento & purificação
Repelentes de Insetos/farmacologia
Poaceae/química
[Mh] Termos MeSH secundário: Animais
Cumarínicos/isolamento & purificação
Cumarínicos/farmacologia
Avaliação Pré-Clínica de Medicamentos/métodos
Etnobotânica
Feminino
Guaiacol/análogos & derivados
Guaiacol/isolamento & purificação
Guaiacol/farmacologia
Seres Humanos
Índios Norte-Americanos
Óleos Voláteis/análise
Óleos Voláteis/química
Fitol/isolamento & purificação
Fitol/farmacologia
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Compostos de Vinila/isolamento & purificação
Compostos de Vinila/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coumarins); 0 (Insect Repellents); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Vinyl Compounds); 150-86-7 (Phytol); 6JKA7MAH9C (Guaiacol); A4VZ22K1WT (coumarin); DA069CTH0O (2-methoxy-4-vinylphenol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161018
[St] Status:MEDLINE



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