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[PMID]:29367489
[Au] Autor:Ogura T; Sato T; Abe M; Okano T
[Ad] Endereço:Research & Development Headquarters, LION Corporation.
[Ti] Título:Small Angle X-ray Scattering and Electron Spin Resonance Spectroscopy Study on Fragrance Infused Cationic Vesicles Modeling Scent-Releasing Fabric Softeners.
[So] Source:J Oleo Sci;67(2):177-186, 2018 Feb 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Industrially relevant systems for household and personal-care products often involve a large number of components. Such multiple component formulations are indispensable and effective for functionalization of the products, but may simultaneously provide more complex structural features compared to those in ideal systems comprising a smaller number of highly pure substances. Using cryogenic transmission electron microscopy (cryo-TEM), small angle X-ray scattering (SAXS), and electron spin resonance (ESR) spectroscopy, we have investigated effects of fragrance-incorporation into cationic vesicles on their bilayer structures and membrane-membrane interactions. Cationic vesicles were prepared from TEQ surfactant, whose major component was di(alkyl fatty ester) quaternary ammonium methosulfate, and fragrance components, l-menthol, linalool, and d-limonene, were infused into the vesicle membranes to model scent-releasing fabric softeners. The cryo-TEM images confirm formation of multilamellar vesicles (MLVs). Generalized indirect Fourier transformation (GIFT) analysis of the SAXS intensities based on the modified Caillé structure factor model reveals that incorporation of a more hydrophobic fragrance component leads to a more pronounced increase of the surface separation (water layer thickness). Furthermore, the fragrance-infused systems show longer-range order of the bilayer correlations and enhanced undulation fluctuation of the membranes than those in the TEQ alone system. The spin-label ESR results indicate different restricted molecular motions in the TEQ bilayers depending on the labeled position and their marked changes upon addition of the fragrance components, suggesting different mixing schemes and solubilization positions of the fragrance molecules in the TEQ bilayers. The present data have demonstrated how the infused fragrance molecules having different hydrophobicity and molecular architectures into the cationic vesicles affect the membrane structures and the intermembrane interactions, which may provide useful information for precisely controlling a fragrance-releasing property.
[Mh] Termos MeSH primário: Cicloexenos/química
Espectroscopia de Ressonância de Spin Eletrônica
Mentol/química
Monoterpenos/química
Odorantes
Espalhamento a Baixo Ângulo
Terpenos/química
Difração de Raios X
[Mh] Termos MeSH secundário: Cátions
Interações Hidrofóbicas e Hidrofílicas
Bicamadas Lipídicas
Membranas Artificiais
Microscopia Eletrônica de Transmissão
Compostos Orgânicos/química
Compostos de Amônio Quaternário/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cations); 0 (Cyclohexenes); 0 (Lipid Bilayers); 0 (Membranes, Artificial); 0 (Monoterpenes); 0 (Organic Chemicals); 0 (Quaternary Ammonium Compounds); 0 (Terpenes); 0 (fabric softeners); 1490-04-6 (Menthol); 9MC3I34447 (limonene); D81QY6I88E (linalool)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17186


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[PMID]:28554232
[Au] Autor:Guo T; Tan SB; Wang Y; Chang J
[Ad] Endereço:a School of Life Science and Engineering , Lanzhou University of Technology , Lanzhou , China.
[Ti] Título:Two new monoterpenoid glycosides from the fresh rhizome of Tongling White Ginger (Zingiber officinale).
[So] Source:Nat Prod Res;32(1):71-76, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new monoterpenoid glycosides, trans-1,8-cineole-3,6-dihydroxy-3-O-ß-D-glucopyranoside (1), and 5,9-dihydroxy borneol 2-O-ß-D-glucopyranoside (2), together with four known monoterpenoid glycosides (3-6), were isolated from the water-soluble constituents of the fresh rhizome of Tongling White Ginger (Zingiber officinale). Their structures were decisively elucidated by spectroscopic analysis. In vitro tests for antimicrobial activity showed that compounds 1 and 3 possess significant activity against two Gram-positive organisms, Staphylococcus aureus and Staphylococcus epidermidis.
[Mh] Termos MeSH primário: Antibacterianos/química
Gengibre/química
Glicosídeos/química
Monoterpenos/química
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Glicosídeos/farmacologia
Espectroscopia de Ressonância Magnética
Testes de Sensibilidade Microbiana
Estrutura Molecular
Monoterpenos/farmacologia
Rizoma/química
Solubilidade
Espectrometria de Massas por Ionização por Electrospray
Staphylococcus aureus/efeitos dos fármacos
Staphylococcus epidermidis/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Glycosides); 0 (Monoterpenes)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1333994


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[PMID]:29374173
[Au] Autor:Shin JH; Kim D; Jung MW
[Ad] Endereço:Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Korea.
[Ti] Título:Differential coding of reward and movement information in the dorsomedial striatal direct and indirect pathways.
[So] Source:Nat Commun;9(1):404, 2018 01 26.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The direct and indirect pathways of the basal ganglia have long been thought to mediate behavioral promotion and inhibition, respectively. However, this classic dichotomous model has been recently challenged. To better understand neural processes underlying reward-based learning and movement control, we recorded from direct (dSPNs) and indirect (iSPNs) pathway spiny projection neurons in the dorsomedial striatum of D1-Cre and D2-Cre mice performing a probabilistic Pavlovian conditioning task. dSPNs tend to increase activity while iSPNs decrease activity as a function of reward value, suggesting the striatum represents value in the relative activity levels of dSPNs versus iSPNs. Lick offset-related activity increase is largely dSPN selective, suggesting dSPN involvement in suppressing ongoing licking behavior. Rapid responses to negative outcome and previous reward-related responses are more frequent among iSPNs than dSPNs, suggesting stronger contributions of iSPNs to outcome-dependent behavioral adjustment. These findings provide new insights into striatal neural circuit operations.
[Mh] Termos MeSH primário: Condicionamento (Psicologia)/fisiologia
Corpo Estriado/fisiologia
Vias Neurais/fisiologia
Neurônios/fisiologia
[Mh] Termos MeSH secundário: Animais
Corpo Estriado/citologia
Sinais (Psicologia)
Eletrodos Implantados
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Monoterpenos
Movimento
Odorantes/análise
Percepção Olfatória/fisiologia
Optogenética
Pentanóis
Receptores de Dopamina D1/fisiologia
Receptores de Dopamina D2/fisiologia
Recompensa
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Monoterpenes); 0 (Pentanols); 0 (Receptors, Dopamine D1); 0 (Receptors, Dopamine D2); 75GK9XIA8I (carvone); T7EU0O9VPP (citral); Z135787824 (isoamyl acetate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180128
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02817-1


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[PMID]:29037700
[Au] Autor:D'Onofrio C; Matarese F; Cuzzola A
[Ad] Endereço:Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto 80, I-56124 Pisa, Italy; Nutraceuticals and Food for Health - Nutrafood, University of Pisa, Via del Borghetto 80, I-56124 Pisa, Italy. Electronic address: claudio.donofrio@unipi.it.
[Ti] Título:Effect of methyl jasmonate on the aroma of Sangiovese grapes and wines.
[So] Source:Food Chem;242:352-361, 2018 Mar 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Methyl jasmonate (MeJA) was applied in a vineyard on leaves and grape clusters of cv Sangiovese to test its ability to stimulate the production of aromas and identify the main genes involved in the biosynthetic pathways switched on by the elicitor. MeJA application led to a delay in grape technological maturity and a significant increase in the concentration of several berry aroma classes (about twice the total aroma: from around 3 to 6µg/g of berry). Of these, monoterpenes showed the most significant increase. An analysis of the expression of terpenoid biosynthesis genes confirmed that the MeJA application activated the related biosynthetic pathway. The expression of all the TPS genes analyzedwas higher in samples treated with MeJA. Also the wines produced by microvinification of Sangiovese treated and untreated grapes showed a rise in the aroma concentration as in berries, with an important impact on longevity and sensorial characters of wines.
[Mh] Termos MeSH primário: Acetatos
Ciclopentanos
Manipulação de Alimentos/métodos
Frutas/química
Odorantes/análise
Oxilipinas
Vitis/química
Vinho/análise
[Mh] Termos MeSH secundário: Regulação da Expressão Gênica de Plantas
Monoterpenos/análise
Monoterpenos/metabolismo
Vitis/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Cyclopentanes); 0 (Monoterpenes); 0 (Oxylipins); 900N171A0F (methyl jasmonate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171018
[St] Status:MEDLINE


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[PMID]:29376212
[Au] Autor:Bustos-Segura C; Foley WJ
[Ad] Endereço:Division of Ecology and Evolution, Research School of Biology, The Australian National University, Canberra, ACT 2601, Australia. bustossc@gmail.com.
[Ti] Título:Foliar Terpene Chemotypes and Herbivory Determine Variation in Plant Volatile Emissions.
[So] Source:J Chem Ecol;44(1):51-61, 2018 Jan.
[Is] ISSN:1573-1561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plants that synthesize and store terpenes in specialized cells accumulate large concentrations of these compounds while avoiding autotoxicity. Stored terpenes may influence the quantity and profile of volatile compounds that are emitted into the environment and the subsequent role of those volatiles in mediating the activity of herbivores. The Australian medicinal tea tree, Melaleuca alternifolia, occurs as several distinct terpene chemotypes. We studied the profile of its terpene emissions to understand how variations in stored foliar terpenes influenced emissions, both constitutive and when damaged either by herbivores or mechanically. We found that foliar chemistry influenced differences in the composition of terpene emissions, but those emissions were minimal in intact plants. When plants were damaged by herbivores or mechanically, the emissions were greatly increased and the composition corresponded to the constitutive terpenes and the volatility of each compound, suggesting the main origin of emissions is the stored terpenes and not de novo biosynthesized volatiles. However, herbivores modified the composition of the volatile emissions in only one chemotype, probably due to the oxidative metabolism of 1,8-cineole by the beetles. We also tested whether the foliar terpene blend acted as an attractant for the specialized leaf beetles Paropsisterna tigrina and Faex sp. and a parasitoid fly, Anagonia zentae. None of these species responded to extracts of young leaves in an olfactometer, so we found no evidence that these species use plant odor cues for host location in laboratory conditions.
[Mh] Termos MeSH primário: Coleópteros/fisiologia
Plantas/química
Terpenos/análise
Compostos Orgânicos Voláteis/química
[Mh] Termos MeSH secundário: Animais
Coleópteros/efeitos dos fármacos
Cicloexanóis/análise
Cicloexanóis/farmacologia
Cromatografia Gasosa-Espectrometria de Massas
Herbivoria/efeitos dos fármacos
Interações Hospedeiro-Parasita/efeitos dos fármacos
Monoterpenos/análise
Monoterpenos/farmacologia
Folhas de Planta/química
Folhas de Planta/metabolismo
Folhas de Planta/parasitologia
Plantas/metabolismo
Plantas/parasitologia
Análise de Componente Principal
Terpenos/metabolismo
Terpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclohexanols); 0 (Monoterpenes); 0 (Terpenes); 0 (Volatile Organic Compounds); RV6J6604TK (eucalyptol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE
[do] DOI:10.1007/s10886-017-0919-8


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[PMID]:29301048
[Au] Autor:Shepherd WP; Sullivan BT
[Ad] Endereço:USDA Forest Service, Southern Research Station, Pineville, LA.
[Ti] Título:Spatial Displacement of a Lure Component Can Reduce Catches of Two Nontarget Species During Spring Monitoring of Southern Pine Beetle.
[So] Source:J Insect Sci;18(1), 2018 Jan 01.
[Is] ISSN:1536-2442
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Local outbreak risk for the southern pine beetle, Dendroctonus frontalis Zimmermann (Coleoptera: Curculionidae), is forecast with a trapping survey conducted every spring throughout the southeastern United States. Traps baited with pine odors and components of the D. frontalis aggregation pheromone are used to obtain abundance estimates of both this species and its clerid predator Thanasimus dubius (F.) (Coleoptera: Cleridae); these data are entered into a predictive model that estimates outbreak risk. An attractant synergist for D. frontalis, endo-brevicomin, has recently been included in the survey lure, but it can have the unintended effect of attracting nontarget species Hylesinus pruinosus Eichhoff (Coleoptera: Curculionidae: Scolytinae) and Enoclerus nigripes (Say) (Coleoptera: Cleridae) which, due to their sometimes large numbers and general similarity in appearance to the target species, could complicate sorting and counting of trap catches. Analysis of bycatch data from a previously-published, 31-mo trapping study in Mississippi indicated that displacement of the endo-brevicomin releaser 6 m from the trap largely eliminated catches of the nontarget species H. pruinosus and E. nigripes while not reducing catches of the target species D. frontalis and T. dubius. Our analysis demonstrates that interspecific differences in spatial responses to attractive semiochemicals can be used to improve insect trap selectivity. Both nontarget beetle species were captured in highest numbers during late winter/early spring, coinciding with the D. frontalis survey.
[Mh] Termos MeSH primário: Compostos Bicíclicos Heterocíclicos com Pontes/administração & dosagem
Controle de Insetos/métodos
Feromônios/administração & dosagem
Gorgulhos
[Mh] Termos MeSH secundário: Animais
Monoterpenos
Pinus
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bridged Bicyclo Compounds, Heterocyclic); 0 (Monoterpenes); 0 (Pheromones); 9T71ZVB55P (frontalin); JPF3YI7O34 (alpha-pinene); KPU1SW45CD (brevicomin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1093/jisesa/iex106


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[PMID]:29292089
[Au] Autor:Yu X; Fan Z; Han Y; Zhang D; Xu L; Wang M; Yang Q; Li H; Zhou M; Zhang L; Sun G; Bai X; Li J; Wang H
[Ad] Endereço:Otolaryngology-Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China; Shandong Provincial Key Laboratory of Otology, Jinan, China; Shandong Institute of Otolaryngology, Jinan, China.
[Ti] Título:Paeoniflorin reduces neomycin-induced ototoxicity in hair cells by suppression of reactive oxygen species generation and extracellularly regulated kinase signalization.
[So] Source:Toxicol Lett;285:9-19, 2018 Mar 15.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present study was designed to investigate the effect of paeoniflorin (PF) on neomycin-induced ototoxicity in hair cells (HCs). Here, we took advantage of C57BL/6 mice and cochlear explants culture to determine the role of PF in vivo and in vitro. We demonstrated that neomycin exposure induced severe hearing loss and HC damage, which was mediated by activated mitochondrial apoptosis pathway, promoted extracellular signal-regulated kinase (ERK) signaling as well as enhanced reactive oxygen species (ROS) generation in HCs. Interestingly, we found that PF pretreatment significantly alleviated neomycin-induced hearing loss, attenuated HC injury and decreased HC apoptosis caused by neomycin. Mechanistic studies revealed that PF could decrease cellular ROS levels, suppress the activation of ERK signaling and, subsequently, mitigate the imbalance of mitochondrial apoptotic pathway, thus protecting HCs from neomycin-induced apoptosis. This study indicates that PF may serve as an antioxidative and anti-apoptotic agent to prevent hearing loss caused by neomycin.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Glucosídeos/uso terapêutico
Células Ciliadas Auditivas/efeitos dos fármacos
Perda Auditiva/prevenção & controle
Monoterpenos/uso terapêutico
Neomicina/toxicidade
Espécies Reativas de Oxigênio/metabolismo
[Mh] Termos MeSH secundário: Animais
Antioxidantes/administração & dosagem
Apoptose/efeitos dos fármacos
Células Cultivadas
Potenciais Evocados Auditivos do Tronco Encefálico/efeitos dos fármacos
Glucosídeos/administração & dosagem
Células Ciliadas Auditivas/metabolismo
Células Ciliadas Auditivas/patologia
Perda Auditiva/induzido quimicamente
Perda Auditiva/metabolismo
Perda Auditiva/patologia
Camundongos Endogâmicos C57BL
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/patologia
Monoterpenos/administração & dosagem
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Glucosides); 0 (Monoterpenes); 0 (Reactive Oxygen Species); 1404-04-2 (Neomycin); 21AIQ4EV64 (peoniflorin); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE


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ALVARENGA, Elson Santiago
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[PMID]:29286652
[Au] Autor:Pinheiro PF; Menini LAP; Bernardes PC; Saraiva SH; Carneiro JWM; Costa AV; Arruda TR; Lage MR; Gonçalves PM; Bernardes CO; Alvarenga ES; Menini L
[Ti] Título:Semisynthetic Phenol Derivatives Obtained from Natural Phenols: Antimicrobial Activity and Molecular Properties.
[So] Source:J Agric Food Chem;66(1):323-330, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Semisynthetic phenol derivatives were obtained from the natural phenols: thymol, carvacrol, eugenol, and guaiacol through catalytic oxychlorination, Williamson synthesis, and aromatic Claisen rearrangement. The compounds characterization was carried out by H NMR, C NMR, and mass spectrometry. The natural phenols and their semisynthetic derivatives were tested for their antimicrobial activity against the bacteria: Staphylococcus aureus, Escherichia coli, Listeria innocua, Pseudomonas aeruginosa, Salmonella enterica Typhimurium, Salmonella enterica ssp. enterica, and Bacillus cereus. Minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values were determined using concentrations from 220 to 3.44 µg mL . Most of the tested compounds presented MIC values ≤220 µg mL for all the bacteria used in the assays. The molecular properties of the compounds were computed with the PM6 method. Through principle components analysis, the natural phenols and their semisynthetic derivatives with higher antimicrobial potential were grouped.
[Mh] Termos MeSH primário: Antibacterianos/síntese química
Antibacterianos/farmacologia
Fenol/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Escherichia coli/efeitos dos fármacos
Eugenol/química
Eugenol/farmacologia
Listeria/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Monoterpenos/química
Monoterpenos/farmacologia
Fenol/síntese química
Fenol/química
Salmonella typhimurium/efeitos dos fármacos
Staphylococcus aureus/efeitos dos fármacos
Timol/química
Timol/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Monoterpenes); 339NCG44TV (Phenol); 3J50XA376E (Thymol); 3T8H1794QW (Eugenol); 9B1J4V995Q (carvacrol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04418


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[PMID]:28448886
[Au] Autor:Wang Z; Tang S; Hattori M; Zhang H; Wang P; Wu X; Zhang N
[Ad] Endereço:Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping road 24, Harbin 150040, China; Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
[Ti] Título:New analytical method for determination of epimer metabolites in rat plasma after oral administration of Paeoniflorin by UPLC-TOF-MS following picolinoyl derivatization.
[So] Source:J Pharm Biomed Anal;141:173-179, 2017 Jul 15.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A highly sensitive analytical method was developed to study the in vivo metabolism of paeoniflorin, one of the most principal components in traditional Chinese medicine. After hydrolyzation with sulfatase, the epimer metabolites 7S-paeonimetabolin I and 7R-paeonimetabolin I of paeoniflorin in rat plasma were successfully detected and well separated by LC-MS following picolinoyl derivatization for the first time. Borneol was used as the internal standard to quantify 7S-paeonimetabolin I and 7R-paeonimetabolin I in rat plasma. 7S-paeonimetabolin I and 7R-paeonimetabolin I show similar but different pharmacokinetic behavior. 7S-paeonimetabolin I reached the maximum mean plasma concentration of 45.7±4.6ng/mL at about 1.5h after oral administration of paeoniflorin at a dose of 5mg/kg, while 7R-paeonimetabolin I reached the maximum mean plasma concentration of 39.2±3.5ng/mL at about 1.5h. The full metabolic pathway of paeoniflorin in rats was proposed. The monoterpene compound paeoniflorin was found to be metabolized to the sulfate of 7S-paeonimetabolin I and 7R-paeonimetabolin I in vivo which maybe responsible for the pharmacological effect of paeoniflorin.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão
Espectrometria de Massas
[Mh] Termos MeSH secundário: Administração Oral
Animais
Medicamentos de Ervas Chinesas
Glucosídeos
Monoterpenos
Ratos
Ratos Sprague-Dawley
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Glucosides); 0 (Monoterpenes); 21AIQ4EV64 (peoniflorin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180125
[Lr] Data última revisão:
180125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE


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[PMID]:29199255
[Au] Autor:Tanahashi T
[Ad] Endereço:Kobe Pharmaceutical University.
[Ti] Título:[Diversity of Secondary Metabolites from Some Medicinal Plants and Cultivated Lichen Mycobionts].
[So] Source:Yakugaku Zasshi;137(12):1443-1482, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Studies on the structural determination, biosynthesis, and biological activities of secondary metabolites from natural sources are significant in the field of natural products chemistry. This review focuses on diverse secondary metabolites isolated from medicinal plants and cultivated mycobionts of lichens in our laboratory. Monoterpene-tetrahydroisoquinoline glycosides and alkaloids isolated from Cephaelis acuminata and Alangium lamarckii gave important information on the biosynthesis of ipecac alkaloids. A variety of glycosides linked with a secologanin unit and indole alkaloids were obtained from medicinal plants belonging to the families of Rubiaceae, Apocynaceae, and Loganiaceae. Plant species of the four genera Fraxinus, Syringa, Jasminum, and Ligustrum of the family Oleaceae were chemically investigated to provide several types of secoiridoid and iridoid glucosides. The biosynthetic pathway leading from protopine to benzophenanthridine alkaloids in suspension cell cultures of Eschscholtzia californica was elucidated. The structures and biological activities of the bisbenzylisoquinoline alkaloids of Stephania cepharantha and Nelumbo nucifera were also investigated. In addition, the mycobionts of lichens were cultivated to afford various types of metabolites that differ from the lichen substances of intact lichens but are structurally similar to fungal metabolites. The biosynthetic origins of some metabolites were also studied. These findings suggest that cultures of lichen mycobionts could be sources of new bioactive compounds and good systems for investigating secondary metabolism in lichens.
[Mh] Termos MeSH primário: Alcaloides/isolamento & purificação
Glicosídeos/isolamento & purificação
Líquens/metabolismo
Plantas Medicinais/metabolismo
[Mh] Termos MeSH secundário: Alangiaceae/metabolismo
Alcaloides/biossíntese
Alcaloides/química
Benzilisoquinolinas
Cephaelis/metabolismo
Eschscholzia/metabolismo
Glicosídeos/biossíntese
Glicosídeos/química
Iridoides
Monoterpenos
Oleaceae/metabolismo
Rubiaceae/metabolismo
Stephania/metabolismo
Tetra-Hidroisoquinolinas
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Benzylisoquinolines); 0 (Glycosides); 0 (Iridoids); 0 (Monoterpenes); 0 (Tetrahydroisoquinolines); 56W89FBX3E (1,2,3,4-tetrahydroisoquinoline)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00147



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