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[PMID]:29311515
[Au] Autor:Suh WS; Kwon OK; Lee TH; Subedi L; Kim SY; Lee KR
[Ad] Endereço:Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University.
[Ti] Título:Secoiridoid Glycosides from the Twigs of Ligustrum obtusifolium Possess Anti-inflammatory and Neuroprotective Effects.
[So] Source:Chem Pharm Bull (Tokyo);66(1):78-83, 2018.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Two new secoiridoid glycosides, obtusifolisides A and B (1, 2), together with 7 known secoiridoid glycosides (3-9) were isolated from the twigs of Ligustrum obtusifolium. The chemical structures of new compounds were determined by a spectroscopic data analysis, including one and two dimensional (1D-, 2D)-NMR, High resolution-MS, and experiments involving chemical reactions. The isolated secoiridoid glycosides were evaluated for their anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated BV-2 murine microglia cells. Compounds 2, 5, 6, 8, and 9 significantly reduced the production of nitric oxide (NO), with IC values of 5.45, 11.17, 14.62, 15.45, and 14.96 µM, respectively. None of the compounds were toxic to the cells. Additionally, we evaluated the neuroprotective effects of compounds 1-9 on nerve growth factor (NGF) induction in a C6 rat glioma cell line. Compounds 2 and 6 upregulated NGF secretion to 155.56±7.16%, and 139.35±11.65%, respectively, without significant cell toxicity.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/farmacologia
Glicosídeos Iridoides/farmacologia
Ligustrum/química
Fármacos Neuroprotetores/farmacologia
Caules de Planta/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides/química
Anti-Inflamatórios não Esteroides/isolamento & purificação
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Glioma/tratamento farmacológico
Glioma/metabolismo
Glicosídeos Iridoides/química
Glicosídeos Iridoides/isolamento & purificação
Lipopolissacarídeos/antagonistas & inibidores
Lipopolissacarídeos/farmacologia
Camundongos
Microglia/efeitos dos fármacos
Microglia/metabolismo
Conformação Molecular
Fatores de Crescimento Neural/antagonistas & inibidores
Fatores de Crescimento Neural/metabolismo
Fármacos Neuroprotetores/química
Fármacos Neuroprotetores/isolamento & purificação
Óxido Nítrico/antagonistas & inibidores
Óxido Nítrico/biossíntese
Ratos
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Iridoid Glycosides); 0 (Lipopolysaccharides); 0 (Nerve Growth Factors); 0 (Neuroprotective Agents); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c17-00720


  2 / 431 MEDLINE  
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[PMID]:29223063
[Au] Autor:Saidi I; Waffo-Téguo P; Ayeb-Zakhama AEL; Harzallah-Skhiri F; Marchal A; Ben Jannet H
[Ad] Endereço:Laboratoire de Chimie Hétérocyclique, Produits Naturels et Réactivité (LR11ES39), Equipe: Chimie Médicinale et Produits Naturels, Faculté des Sciences de Monastir, Université de Monastir, Avenue de l'environnement, 5019 Monastir, Tunisia.
[Ti] Título:Phytochemical study of the trunk bark of Citharexylum spinosum L. growing in Tunisia: Isolation and structure elucidation of iridoid glycosides.
[So] Source:Phytochemistry;146:47-55, 2018 Feb.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A phytochemical investigation of the trunk bark ethyl acetate extract of Citharexylum spinosum L. has led to the isolation of four previously undescribed iridoid glycosides, tunispinosides A-D, and five known phenylethanoid glycosides, verbascoside, leucosceptoside A, martynoside, isoverbascoside and plantainoside C, together with 4-hydroxy-2,6-dimethoxyphenyl 6'-O-vanilloyl-ß-D-glucopyranoside, two 8,3'-neolignan glycosides, plucheosides D -D , coniferyl aldehyde, vanillic acid, syringic acid, ferulic acid and tyrosol. All compounds were isolated for the first time from C. spinosum. Their isolation was carried out using silica gel column and high performance liquid chromatography (HPLC). Structures were established by spectroscopic means including 1D and 2D NMR experiments, and spectrometric ESI-HRMS analysis.
[Mh] Termos MeSH primário: Glicosídeos Iridoides/isolamento & purificação
Compostos Fitoquímicos/isolamento & purificação
Casca de Planta/química
Verbenaceae/química
[Mh] Termos MeSH secundário: Glicosídeos Iridoides/química
Estrutura Molecular
Compostos Fitoquímicos/química
Tunísia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iridoid Glycosides); 0 (Phytochemicals)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171210
[St] Status:MEDLINE


  3 / 431 MEDLINE  
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[PMID]:28841320
[Au] Autor:Suh WS; Kim CS; Subedi L; Kim SY; Choi SU; Lee KR
[Ad] Endereço:Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University , Suwon 16419, Republic of Korea.
[Ti] Título:Iridoid Glycosides from the Twigs of Sambucus williamsii var. coreana and Their Biological Activities.
[So] Source:J Nat Prod;80(9):2502-2508, 2017 Sep 22.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Six new iridoid glycosides, sambucusides A-F (1-6), and two known derivatives (7 and 8) were isolated from a methanol extract of the twigs of Sambucus williamsii var. coreana. Their chemical structures were elucidated by spectroscopic methods, including NMR ( H and C NMR, H- H COSY, HMQC, HMBC, and NOESY) and HRMS. All isolated compounds (1-8) were evaluated for their antiproliferative activities against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, and Bt549). Their effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells and their neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells were also examined. Compounds 2, 3, and 5 showed cytotoxic effects (IC 1.3-8.7 µM) against the SK-MEL-2 and Bt549 cell lines and inhibitory effects on NO production (IC of 0.9, 1.3, and 1.2 µM, respectively). Compounds 2, 4, and 8 exhibited NGF-releasing effects (147.0 ± 5.8%, 158.7 ± 5.2%, and 152.6 ± 7.3%, respectively).
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Glicosídeos Iridoides/isolamento & purificação
Glicosídeos Iridoides/farmacologia
Lipopolissacarídeos/farmacologia
Fator de Crescimento Neural/metabolismo
Fármacos Neuroprotetores/metabolismo
Óxido Nítrico/análise
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Linhagem Celular Tumoral
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Glicosídeos Iridoides/química
Lipopolissacarídeos/química
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Fator de Crescimento Neural/química
Fármacos Neuroprotetores/química
Sambucus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Iridoid Glycosides); 0 (Lipopolysaccharides); 0 (NGF protein, human); 0 (Neuroprotective Agents); 0 (sambucuside); 31C4KY9ESH (Nitric Oxide); 9061-61-4 (Nerve Growth Factor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00410


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[PMID]:28728914
[Au] Autor:Dudek MK; Michalak B; Wozniak M; Czerwinska ME; Filipek A; Granica S; Kiss AK
[Ad] Endereço:Centre of Molecular and Macromolecular Studies of Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland.
[Ti] Título:Hydroxycinnamoyl derivatives and secoiridoid glycoside derivatives from Syringa vulgaris flowers and their effects on the pro-inflammatory responses of human neutrophils.
[So] Source:Fitoterapia;121:194-205, 2017 Sep.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Thirteen new compounds including caffeoyl-glucaric and p-coumaroyl-altraric acid derivatives, one monoterpenoid glucoside, four secoiridoid glycosides, and three hydroxycinnamoyl phenylpropanoid glycosides esterified with an oleoside 11-methyl ester along with fifteen known compounds were isolated from flowers of Syringa vulgaris L. (Oleaceae). Their structures were elucidated by high-resolution spectroscopic methods. The tested compounds were able to decrease the production of reactive oxygen species. Moreover, oleoechinacoside (13), demethylhydroxyoleonuezhenide (14), demethyloleonuezhenide (15), syringaoleoacteoside (25) and oleoacteoside (26) at the concentration of 50µM, moderately suppressed the LPS-stimulated release of pro-inflammatory chemokine IL-8 and TNF-α from human neutrophils. Moreover, oleonuezhenide (12), oleoside 11-methyl ester (16) and oleoacteoside (26) at the concentration of 50µM were able to induce the surface expression of interleukin 10 receptor, which is suppressed by the incubation of monocyte/macrophage cells with LPS.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Flores/química
Glicosídeos Iridoides/farmacologia
Neutrófilos/efeitos dos fármacos
Syringa/química
[Mh] Termos MeSH secundário: Anti-Inflamatórios/isolamento & purificação
Células Cultivadas
Glucosídeos/isolamento & purificação
Glucosídeos/farmacologia
Glicosídeos
Seres Humanos
Interleucina-8/metabolismo
Glicosídeos Iridoides/isolamento & purificação
Macrófagos/efeitos dos fármacos
Estrutura Molecular
Extratos Vegetais/química
Receptores de Interleucina-10/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Glucosides); 0 (Glycosides); 0 (IL8 protein, human); 0 (Interleukin-8); 0 (Iridoid Glycosides); 0 (Plant Extracts); 0 (Receptors, Interleukin-10); 0 (Tumor Necrosis Factor-alpha); 0 (oleoacteoside); 0 (oleoechinacoside)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE


  5 / 431 MEDLINE  
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[PMID]:28618355
[Au] Autor:Ngo QT; Lee HS; Nguyen VT; Kim JA; Woo MH; Min BS
[Ad] Endereço:College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongbuk, 38430, Republic of Korea.
[Ti] Título:Chemical constituents from the fruits of Ligustrum japonicum and their inhibitory effects on T cell activation.
[So] Source:Phytochemistry;141:147-155, 2017 Sep.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A previously undescribed nor-dammarane, 3ß,20,23-trihydroxy-24,25,26,27-tetranordammarane; three previously undescribed secoiridoid glycosides, ligujaponosides A-B, and iso-oleonuzhenide; and twenty three known compounds, were isolated from the fruits of Ligustrum japonicum Thunb. Their chemical structures were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR, and HRMS. The isolated compounds were screened for immunosuppressive effects on T activated cells by evaluating interleukin-2 (IL-2) production. Among them, sesamin inhibited IL-2 production in Jurkat T cells with an IC value of 38 ± 2 µM. In addition, sesamin inhibited the phosphorylation of extracellular signal-regulated protein kinase (ERK), a member of the mitogen-activated protein kinase (MAPK) family, in phorbol 12-myristate 13-acetate (PMA)/A23187-stimulated T cells. Therefore, sesamin was demonstrated to inhibit T cell activation via regulation of MAPK phosphorylation pathway.
[Mh] Termos MeSH primário: Glicosídeos Iridoides/farmacologia
Ligustrum/química
Ativação Linfocitária/efeitos dos fármacos
Linfócitos T/efeitos dos fármacos
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Frutas/química
Seres Humanos
Interleucina-2/metabolismo
Glicosídeos Iridoides/isolamento & purificação
Células Jurkat
Proteínas Quinases Ativadas por Mitógeno/metabolismo
Estrutura Molecular
Fosforilação
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (IL2 protein, human); 0 (Interleukin-2); 0 (Iridoid Glycosides); 0 (Triterpenes); 545-22-2 (dammarane); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE


  6 / 431 MEDLINE  
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[PMID]:28589423
[Au] Autor:Kelly CA; Bowers MD
[Ad] Endereço:Department of Ecology and Evolutionary Biology and, University of Colorado Museum of Natural History, University of Colorado Boulder, UCB 334, Boulder, CO, 80309, USA. caitlin.a.kelly@colorado.edu.
[Ti] Título:The Perennial Penstemon: Variation in Defensive Chemistry Across Years, Populations, and Tissues.
[So] Source:J Chem Ecol;43(6):599-607, 2017 Jun.
[Is] ISSN:1573-1561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plants produce a variety of secondary metabolites that function as a defense against their natural enemies. Production of these secondary metabolites is genetically controlled, but is also phenotypically plastic and varies in response to both biotic and abiotic factors. Therefore, plant species may vary widely in their chemical defenses and such variation can be evident at temporal, spatial and tissue levels. Focusing on the chemical defenses of a native Colorado wildflower, Penstemon virgatus, we assessed the variation in iridoid glycoside (IG) content across two non-consecutive growing seasons, six natural populations and three tissue types: leaves, stems and flowers. Our results indicate that P. virgatus plants contain high concentrations of IGs (mean = 23.36% dry weight of leaves) and that IGs were differentially allocated among tissue types. Leaves contained the highest concentration of IGs, which varied quantitatively between sampling years, among plant populations, and plant parts. We also quantified leaf herbivore damage at all six populations but we found very little herbivore damage. Our study indicates that the IG concentrations of P. virgatus plants are both spatially and temporally variable. Furthermore, the high concentrations of secondary metabolites combined with the low levels of damage suggest that these plants are well defended against generalist herbivores.
[Mh] Termos MeSH primário: Herbivoria
Glicosídeos Iridoides/química
Iridoides/química
Penstemon/química
Penstemon/metabolismo
[Mh] Termos MeSH secundário: Animais
Cromatografia Gasosa
Flores/química
Flores/metabolismo
Glicosídeos Iridoides/metabolismo
Iridoides/metabolismo
Folhas de Planta/química
Folhas de Planta/metabolismo
Caules de Planta/química
Caules de Planta/metabolismo
Plantaginaceae/química
Compostos Orgânicos Voláteis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iridoid Glycosides); 0 (Iridoids); 0 (Volatile Organic Compounds); 0 (scutelloside)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1007/s10886-017-0854-8


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[PMID]:28511931
[Au] Autor:Ji W; Wang T; Liu W; Liu F; Guo L; Geng Y; Wang X
[Ad] Endereço:Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Shandong Academy of Sciences,19 Keyuan Street, Jinan, 250014, China. Electronic address: jwh519@163.com.
[Ti] Título:Water-compatible micron-sized monodisperse molecularly imprinted beads for selective extraction of five iridoid glycosides from Cornus officinalis fructus.
[So] Source:J Chromatogr A;1504:1-8, 2017 Jun 30.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:An efficient, accurate and sensitive method for the determination of five iridoid glycosides (IGs) in Cornus officinalis fructus using molecularly imprinted solid phase extraction (MISPE) coupled with high performance liquid chromatography (HPLC) has been developed. Water-compatible molecularly imprinted beads (MIBs) were synthesized by precipitation polymerization, using alkenyl glycosides glucose as the hydrophilic functional monomer. Scanning electron microscopy showed that the MIBs had a narrow particle size distribution, with diameters in the range 7.5-9.3µm. The special molecular recognition by the MIBs of IGs in aqueous media was verified by static adsorption, kinetic adsorption, and selectivity experiments. The newly prepared MIBs were used as sorbents in solid phase extraction (SPE) for the selective recognition of five IGs (loganin, morroniside, loganic acid, 7-O-ethyl-morroniside and 7-O-methyl morroniside) in Cornus officinalis fructus. When optimized, the MISPE-HPLC method had good linearity (0.02-100mgg ), with correlation coefficient (R)≥0.994. Recoveries at three spiked levels were in the range 80.0%-94.0%. Because of its excellent specificity and hydrophilicity, SPE based on monodisperse MIBs provides a promising pretreatment strategy for the analysis of active components in natural products, especially for the quality control of traditional Chinese medicines.
[Mh] Termos MeSH primário: Cornus/química
Glicosídeos Iridoides/isolamento & purificação
Polímeros/química
Extração em Fase Sólida/métodos
[Mh] Termos MeSH secundário: Adsorção
Cromatografia Líquida de Alta Pressão/métodos
Medicamentos de Ervas Chinesas/química
Frutas/química
Interações Hidrofóbicas e Hidrofílicas
Glicosídeos Iridoides/química
Impressão Molecular
Polímeros/síntese química
Extração em Fase Sólida/instrumentação
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Iridoid Glycosides); 0 (Polymers)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE


  8 / 431 MEDLINE  
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[PMID]:28393296
[Au] Autor:Mason PA; Deane Bowers M
[Ad] Endereço:Department of Ecology and Evolutionary Biology, University of Colorado, UCB 334, Boulder, CO, 80309, USA. pmason@bhsec.bard.edu.
[Ti] Título:Localization of Defensive Chemicals in Two Congeneric Butterflies (Euphydryas, Nymphalidae).
[So] Source:J Chem Ecol;43(5):480-486, 2017 May.
[Is] ISSN:1573-1561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Many insect species sequester compounds acquired from their host plants for defense against natural enemies. The distribution of these compounds is likely to affect both their efficacy as defenses, and their costs. In this study we examined the distribution of sequestered iridoid glycosides (IGs) in two congeneric species of nymphalid butterfly, Euphydryas anicia and E. phaeton, and found that the pattern of localization of IGs differed between the two species. Although IG concentrations were quite high in the heads of both species, the relative concentrations in wings and abdomens differed substantially. Euphydryas anicia had relatively high IG concentrations in their abdomens and low IG concentrations in their wings, whereas the reverse was true in E. phaeton. We interpret these results in light of two current hypotheses regarding where sequestered chemicals should be localized: that they should be found in wings, which would allow non-lethal sampling by predators; and that their distribution is constrained by the distribution of tissue types to which sequestered compounds bind. We also offer the third hypothesis, that costs of storage may differ among body parts, and that the localization of compounds may reflect a cost-reduction strategy. Results from E. phaeton were consistent with all three of these non-mutually exclusive hypotheses, whereas results from E. anicia were only consistent with the notion that tissue bias among body parts plays a role in IG distribution. The finding that these two congeneric butterflies exhibit different patterns of IG localization suggests that they have been shaped by different selection regimes.
[Mh] Termos MeSH primário: Borboletas/química
Glicosídeos Iridoides/análise
[Mh] Termos MeSH secundário: Animais
Borboletas/metabolismo
Cromatografia Gasosa
Feminino
Glicosídeos Iridoides/isolamento & purificação
Masculino
Tórax/química
Tórax/metabolismo
Asas de Animais/química
Asas de Animais/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iridoid Glycosides)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.1007/s10886-017-0841-0


  9 / 431 MEDLINE  
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[PMID]:28332230
[Au] Autor:Feng W; Dong Q; Liu M; Li S; Liu T; Wang X; Niu L
[Ad] Endereço:Hebei TCM Formula Granule Engineering & Technology Research Center, Hebei University of Chinese Medicine, Shijiazhuang, China.
[Ti] Título:Screening and identification of multiple constituents and their metabolites of Zhi-zi-chi decoction in rat urine and bile by ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry.
[So] Source:Biomed Chromatogr;31(10), 2017 Oct.
[Is] ISSN:1099-0801
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Zhi-zi-chi decoction (ZZCD) is a classical formula widely used in Chinese clinical application. In the present study, a novel and efficient strategy has been developed for screening and identification of multiple constituents and their metabolites of ZZCD using ultra-high-performance liquid chromatography combined with triple time-of-flight mass spectrometry. The novel approach of an online data acquisition method dependent on multiple mass defect filter and dynamic background subtraction is combined with multiple data processing techniques. First, a total of 109 potential bioactive compounds were detected in ZZCD. Based on the same instrumental conditions, 100 compounds were found in rat biofluids after oral administration of ZZCD, including 61 original compounds of ZZCD as well as 39 metabolites. Conjugations with sulfate, glucuronate and amino acids were found as the predominant metabolic reaction of ZZCD. As more xenobiotics were detected in urine than those in bile were, it demonstrated that multiple components of ZZCD have undergone comprehensive renal excretion. This study reported the urinary and biliary excretion in rats after oral administration of ZZCD for the first time. The present study expands our knowledge about the constituents and metabolism of ZZCD, which could be very useful for further pharmacological and clinical studies of ZZCD.
[Mh] Termos MeSH primário: Bile/química
Cromatografia Líquida de Alta Pressão/métodos
Medicamentos de Ervas Chinesas/análise
Medicamentos de Ervas Chinesas/metabolismo
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Medicamentos de Ervas Chinesas/química
Glicosídeos Iridoides/análise
Glicosídeos Iridoides/química
Glicosídeos Iridoides/metabolismo
Glicosídeos Iridoides/urina
Ratos
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Iridoid Glycosides)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1002/bmc.3978


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[PMID]:28024298
[Au] Autor:Sollars ES; Harper AL; Kelly LJ; Sambles CM; Ramirez-Gonzalez RH; Swarbreck D; Kaithakottil G; Cooper ED; Uauy C; Havlickova L; Worswick G; Studholme DJ; Zohren J; Salmon DL; Clavijo BJ; Li Y; He Z; Fellgett A; McKinney LV; Nielsen LR; Douglas GC; Kjær ED; Downie JA; Boshier D; Lee S; Clark J; Grant M; Bancroft I; Caccamo M; Buggs RJ
[Ad] Endereço:School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, UK.
[Ti] Título:Genome sequence and genetic diversity of European ash trees.
[So] Source:Nature;541(7636):212-216, 2017 01 12.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ash trees (genus Fraxinus, family Oleaceae) are widespread throughout the Northern Hemisphere, but are being devastated in Europe by the fungus Hymenoscyphus fraxineus, causing ash dieback, and in North America by the herbivorous beetle Agrilus planipennis. Here we sequence the genome of a low-heterozygosity Fraxinus excelsior tree from Gloucestershire, UK, annotating 38,852 protein-coding genes of which 25% appear ash specific when compared with the genomes of ten other plant species. Analyses of paralogous genes suggest a whole-genome duplication shared with olive (Olea europaea, Oleaceae). We also re-sequence 37 F. excelsior trees from Europe, finding evidence for apparent long-term decline in effective population size. Using our reference sequence, we re-analyse association transcriptomic data, yielding improved markers for reduced susceptibility to ash dieback. Surveys of these markers in British populations suggest that reduced susceptibility to ash dieback may be more widespread in Great Britain than in Denmark. We also present evidence that susceptibility of trees to H. fraxineus is associated with their iridoid glycoside levels. This rapid, integrated, multidisciplinary research response to an emerging health threat in a non-model organism opens the way for mitigation of the epidemic.
[Mh] Termos MeSH primário: Fraxinus/genética
Predisposição Genética para Doença/genética
Variação Genética
Genoma de Planta/genética
Doenças das Plantas/genética
Árvores/genética
[Mh] Termos MeSH secundário: Ascomicetos/patogenicidade
Sequência Conservada/genética
Dinamarca
Fraxinus/microbiologia
Genes de Plantas/genética
Genômica
Glicosídeos Iridoides/metabolismo
Doenças das Plantas/microbiologia
Doenças das Plantas/prevenção & controle
Proteínas de Plantas/genética
Densidade Demográfica
Análise de Sequência de DNA
Especificidade da Espécie
Transcriptoma
Árvores/microbiologia
Reino Unido
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Iridoid Glycosides); 0 (Plant Proteins)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161227
[St] Status:MEDLINE
[do] DOI:10.1038/nature20786



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