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Pesquisa : D02.455.849.575.500.500.500 [Categoria DeCS]
Referências encontradas : 635 [refinar]
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[PMID]:29408431
[Au] Autor:Li Y; Hu W; Han G; Lu W; Jia D; Hu M; Wang D
[Ad] Endereço:Department of Orthodontics, School and Hospital of Stomatology, Jilin University, Changchun 130021, China; Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China. Electronic address: m18643107595@163.com.
[Ti] Título:Involvement of bone morphogenetic protein-related pathways in the effect of aucubin on the promotion of osteoblast differentiation in MG63 cells.
[So] Source:Chem Biol Interact;283:51-58, 2018 Mar 01.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Aucubin, an iridoid glycoside found in several plants, such as Eucommia ulmoide and Rehmannia, has various pharmacological effects. Bone formation is a complex process in which osteoblast differentiation plays an important role. This study aimed to investigate the promotion effects of aucubin on osteoblast differentiation in MG63 cells, a human osteoblast-like cell line. Aucubin not only improved osteoblast differentiation, as shown by enhanced ALP (alkaline phosphatase) concentration and mineralization in cells, but increased the expression of various cytokines, including collagen I, osteocalcin, osteopontin, integrin ß1, and Osterix. Aucubin strongly enhanced the levels of BMP2 (bone morphogenetic proteins-2) in MG63 cells, which play a central role during osteoblast differentiation. Further data show that aucubin exposure after 1 day, 7 days, and 14 days enhanced the expression of Smad1, 5, and 8, and the phosphoresced levels of MAPKs (mitogen-activated protein kinases) family Erk (extracellular signal-regulated kinases), JNK (c-Jun-NH2-terminal kinases), P38, and Akt (serine/threonine protein kinase)/mTOR (mammalian target of rapamycin)/p70s6k in MG63 cells. This study shows the improved effects of aucubin on osteoblast differentiation in MG63 cells, related to the signaling of BMP2-mediated Smads (drosophila mothers against decapentaplegic proteins), MAPKs, and Akt/mTOR/p70S6K. This study indicates the potential of aucubin for osteoporosis treatment.
[Mh] Termos MeSH primário: Proteína Morfogenética Óssea 2/metabolismo
Diferenciação Celular/efeitos dos fármacos
Glucosídeos Iridoides/farmacologia
[Mh] Termos MeSH secundário: Linhagem Celular
Proliferação Celular/efeitos dos fármacos
Colágeno Tipo I/metabolismo
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Seres Humanos
Glucosídeos Iridoides/química
Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Osteoblastos/citologia
Osteoblastos/efeitos dos fármacos
Osteoblastos/metabolismo
Osteocalcina/metabolismo
Osteopontina/metabolismo
Fosforilação/efeitos dos fármacos
Proteínas Proto-Oncogênicas c-akt/metabolismo
Proteína Smad1/metabolismo
Proteína Smad5/metabolismo
Proteína Smad8/metabolismo
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (BMP2 protein, human); 0 (Bone Morphogenetic Protein 2); 0 (Collagen Type I); 0 (Iridoid Glucosides); 0 (Smad1 Protein); 0 (Smad5 Protein); 0 (Smad8 Protein); 104982-03-8 (Osteocalcin); 106441-73-0 (Osteopontin); 2G52GS8UML (aucubin); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:29278701
[Au] Autor:Chen C; Wang YY; Wang YX; Cheng MQ; Yin JB; Zhang X; Hong ZP
[Ad] Endereço:School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan, China; Department of Urological Surgery, The 1st Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
[Ti] Título:Gentiopicroside ameliorates bleomycin-induced pulmonary fibrosis in mice via inhibiting inflammatory and fibrotic process.
[So] Source:Biochem Biophys Res Commun;495(4):2396-2403, 2018 01 22.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pulmonary fibrosis (PF) is a chronic and ultimately fatal interstitial lung disease of various causes. The advent of nintedanib and pirfenidone provides treatment options for PF patients for the first time. However, the adverse effects of the two drugs such as gastrointestinal disorders and hepatic dysfunction often lead to treatment discontinuation. Gentiopicroside (GPS) is a natural secoiridoid glycoside from gentian species of medicinal plants, and has a variety of pharmacological activities, including hepatoprotective and cholagogic, anti-inflammatory, antinociceptive, and smooth muscle relaxing activities. The present study aimed to investigate the therapeutical effects of GPS on bleomycin (BLM)-induced PF in mice. Severe lung inflammation and fibrosis were observed in BLM-treated mice. GPS significantly ameliorated inflammatory and fibrotic responses in lungs of PF mice which were confirmed by histopathological examinations including light microscopy and transmission electron microscopy. Additionally, GPS significantly decreased the levels of inflammatory cytokines including TNF-α and IL-1ß in bronchoalveolar lavage fluid and reduced the content of hydroxyproline in lungs of PF mice. Furthermore, GPS significantly downregulated the expression of TGF-ß1 and CTGF in lungs of PF mice. In vitro, GPS inhibited epithelial-mesenchymal transition of A549 cells stimulated by TGF-ß1, in a dose-dependent manner. Our findings suggest that GPS has the potential as an ideal drug candidate for PF, as it has both anti-inflammatory and anti-fibrotic effects. Alveolar epithelial cells and TGF-ß1 may be the main target cells and molecule of GPS on BLM-induced PF, respectively.
[Mh] Termos MeSH primário: Glucosídeos Iridoides/administração & dosagem
Pulmão/imunologia
Pneumonia/imunologia
Pneumonia/prevenção & controle
Fibrose Pulmonar/imunologia
Fibrose Pulmonar/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/administração & dosagem
Bleomicina
Citocinas/imunologia
Relação Dose-Resposta a Droga
Fatores Imunológicos/imunologia
Pulmão/efeitos dos fármacos
Masculino
Camundongos
Pneumonia/induzido quimicamente
Fibrose Pulmonar/induzido quimicamente
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Immunologic Factors); 0 (Iridoid Glucosides); 0WE09Z21RC (gentiopicroside); 11056-06-7 (Bleomycin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE


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[PMID]:28464271
[Au] Autor:Yang X; Gao W; Wang B; Wang X; Guo H; Xiao Y; Kong L; Hao D
[Ad] Endereço:Hong-Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, 710054, China.
[Ti] Título:Picroside II Inhibits RANKL-Mediated Osteoclastogenesis by Attenuating the NF-κB and MAPKs Signaling Pathway In Vitro and Prevents Bone Loss in Lipopolysaccharide Treatment Mice.
[So] Source:J Cell Biochem;118(12):4479-4486, 2017 Dec.
[Is] ISSN:1097-4644
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Picroside II, one of the major components isolated from the seed of natural plant picrorhiza, is widely used in traditional Chinese medicine. The present study was performed to define effects of picroside II on nuclear factor-kappaB ligand (RANKL)-stimulated osteoclast differentiation in vitro and on lipopolysaccharide (LPS)-induced bone loss in vivo. The bone marrow cells (BMMs) were harvested and induced with RANKL followed by treatment with picroside II at several doses, and the differentiation of osteoclasts from these cells was evaluated by tartrate-resistant acid phosphatase (TRAP) staining and resorption pit formation assay. The effects of picroside II on osteoclastogenesis were studied by examining RANKL-induced osteoclast F-actin ring formation and osteoclast bone resorption. Moreover, we explored the mechanisms of these downregulation effects by performed Western blotting and quantitative RT-PCR examination. Results demonstrated picroside II strongly inhibited RANKL-induced osteoclast formation when added during the early stage of BMMs cultures, suggesting that it acts on osteoclast precursors to inhibit RANKL/RANK signaling. Moreover, picroside II markedly decreased the phosphorylation of p38, ERK, JNK, p65, and I-κB degradation, and significantly suppressed c-Fos and nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), both the key transcription factors during osteoclastogenesis. Furthermore, in vivo studies verified the bone protection effects of picroside II. These results collectively suggested that picroside II acted as an anti-resorption agent by blocking osteoclast activation. J. Cell. Biochem. 118: 4479-4486, 2017. © 2017 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Cinamatos/farmacologia
Glucosídeos Iridoides/farmacologia
Lipopolissacarídeos/toxicidade
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
NF-kappa B/metabolismo
Osteoclastos/metabolismo
Osteólise
Receptor Ativador de Fator Nuclear kappa-B/metabolismo
[Mh] Termos MeSH secundário: Animais
Camundongos
Osteoclastos/patologia
Osteólise/induzido quimicamente
Osteólise/metabolismo
Osteólise/patologia
Osteólise/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cinnamates); 0 (Iridoid Glucosides); 0 (Lipopolysaccharides); 0 (NF-kappa B); 0 (Receptor Activator of Nuclear Factor-kappa B); 0 (Tnfrsf11a protein, mouse); 39012-20-9 (picroside II)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1002/jcb.26105


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[PMID]:28934681
[Au] Autor:Xiong K; Gao T; Zhang T; Wang Z; Han H
[Ad] Endereço:Experiment Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China.
[Ti] Título:Simultaneous determination of gentiopicroside and its two active metabolites in rat plasma by LC-MS/MS and its application in pharmacokinetic studies.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1065-1066:1-7, 2017 Oct 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Gentiopicroside is a natural secoiridoid glycoside that may require metabolic activation to exert pharmacological effects. In this study, two active metabolites of gentiopicroside (M1 and M2) were isolated from rat urines and identified with our previous method. Most importantly, a fast, sensitive and selective ultra high-performance liquid chromatography-tandem mass spectrometry method was developed to simultaneously determine gentiopicroside and its two metabolites in rat plasma. The analytes and internal standard (swertiamarin) were separated on an ACQUITY UPLC BEH C18 column (2.1×50mm, 1.7µm) using gradient elution by acetonitrile and 0.1% formic acid at a flow rate of 0.4mL/min. The mass spectrometry detector was operated in the multiple reaction monitoring with positive ionization mode. The method had a good linearity over the concentration range of 0.2-10,000ng/mL for gentiopicroside and 0.1-5000ng/mL for the two metabolites. The validated method was successfully applied to the pharmacokinetic study of gentiopicroside and its metabolites after single oral administration of gentiopicroside (150mg/kg) to rats (n=8). The pharmacokinetic differences between gentiopicroside and its two metabolites were identified.Results provided the evidence for in vivo metabolism-based activation of gentiopicroside.
[Mh] Termos MeSH primário: Cromatografia Líquida/métodos
Glucosídeos Iridoides/sangue
Glucosídeos Iridoides/farmacocinética
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Estabilidade de Medicamentos
Glucosídeos Iridoides/química
Limite de Detecção
Modelos Lineares
Masculino
Ratos
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iridoid Glucosides); 0WE09Z21RC (gentiopicroside)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE


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[PMID]:28919395
[Au] Autor:Yang Y; Yin B; Lv L; Wang Z; He J; Chen Z; Wen X; Zhang Y; Sun W; Li Y; Zhao Y
[Ad] Endereço:Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an 710069, China; Biomedicine Key Laboratory of Shaanxi Province, College of Life Science, Northwest University, Xi'an 710069, China.
[Ti] Título:Gastroprotective effect of aucubin against ethanol-induced gastric mucosal injury in mice.
[So] Source:Life Sci;189:44-51, 2017 Nov 15.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: Aucubin, an iridoid glycoside, was isolated from seeds of Eucommia ulmoides Oliver. This study was aimed to evaluate the protective effect of aucubin against ethanol-induced gastric mucosal injury in mice. MATERIALS AND METHODS: Mice were orally administrated with aucubin (20, 40 and 80mg/kg) for 3 consecutive days. On the 3rd day, the mice of gastric mucosal injury were induced with 70% ethanol after the last administration of aucubin. Gastric tissue of mice were submitted for evaluating the severity of gastric mucosal injury. The protective effect of aucubin was evaluated by the gastric ulcer index and histological examinations and determining the levels of inflammatory cytokines, oxidative stress and some gastric mucosal protection factors. KEY FINDINGS: Prophylactic oral administration of aucubin decreased gastric ulcer indexes and histological scores. A significant decrease of myeloperoxidase (MPO) activity and the levels of malondialdehyde (MDA), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were observed in aucubin administrated groups. In addition, mice administrated with aucubin increased glutathione (GSH) and heat shock protein-70 (HSP-70) levels and superoxide dismutase (SOD) activity, as well as normalized the levels of epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) and cyclooxygenase-1 (COX-1) in gastric tissue of mice. SIGNIFICANCE: The findings of this study demonstrated that aucubin shows protective effect against ethanol-induced acute gastric mucosal injury through its anti-inflammatory and anti-oxidant effects. Furthermore, aucubin enhanced gastric mucosal protection by up-regulation of HSP-70 level and normalization of EGF, VEGF and COX-1 levels.
[Mh] Termos MeSH primário: Etanol/toxicidade
Eucommiaceae/química
Mucosa Gástrica/efeitos dos fármacos
Glucosídeos Iridoides/farmacologia
Úlcera Gástrica/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Antioxidantes/administração & dosagem
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Citocinas/metabolismo
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Mucosa Gástrica/patologia
Glutationa/metabolismo
Proteínas de Choque Térmico HSP70/metabolismo
Interleucina-6/metabolismo
Glucosídeos Iridoides/administração & dosagem
Glucosídeos Iridoides/isolamento & purificação
Masculino
Malondialdeído/metabolismo
Camundongos
Estresse Oxidativo/efeitos dos fármacos
Peroxidase/metabolismo
Sementes
Úlcera Gástrica/induzido quimicamente
Fator de Necrose Tumoral alfa/metabolismo
Regulação para Cima/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Cytokines); 0 (HSP70 Heat-Shock Proteins); 0 (Interleukin-6); 0 (Iridoid Glucosides); 0 (Tumor Necrosis Factor-alpha); 2G52GS8UML (aucubin); 3K9958V90M (Ethanol); 4Y8F71G49Q (Malondialdehyde); EC 1.11.1.7 (Peroxidase); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE


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[PMID]:28787158
[Au] Autor:Kil YS; Kim SM; Kang U; Chung HY; Seo EK
[Ad] Endereço:College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University , Seoul 03760, Korea.
[Ti] Título:Peroxynitrite-Scavenging Glycosides from the Stem Bark of Catalpa ovata.
[So] Source:J Nat Prod;80(8):2240-2251, 2017 Aug 25.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ten new glycosides, 6,10-O-di-trans-feruloyl catalpol (1), 6,6'-O-di-trans-feruloyl catalpol (2), 3,4-dihydro-6-O-di-trans-feruloyl catalpol (10), (8R,7'S,8'R)-lariciresinol 9'-O-ß-d-(6-O-trans-feruloyl)glucopyranoside (17), and ovatosides A-F (18-22, 24), were isolated from the stem bark of Catalpa ovata along with 19 known compounds. All isolates, except 6 (catalposide) and 9 (6-O-veratroyl catalpol), were found to scavenge peroxynitrite (ONOO ) formed by 3-morpholinosydnonimine. In particular, 12 compounds showed potent activity, with IC values in the range 0.14-2.2 µM.
[Mh] Termos MeSH primário: Bignoniaceae/química
Furanos/química
Furanos/isolamento & purificação
Glucosídeos/química
Glucosídeos/isolamento & purificação
Glicosídeos/química
Glicosídeos/isolamento & purificação
Glucosídeos Iridoides/química
Glucosídeos Iridoides/isolamento & purificação
Iridoides/química
Iridoides/isolamento & purificação
Lignanas/química
Lignanas/isolamento & purificação
Ácido Peroxinitroso/química
Ácido Peroxinitroso/isolamento & purificação
[Mh] Termos MeSH secundário: Concentração Inibidora 50
Estrutura Molecular
Caules de Planta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3,4-dihydro-6-O-di-trans-feruloyl catalpol); 0 (6,10-O-di-trans-feruloyl catalpol); 0 (6-O-veratroyl catalpol); 0 (Furans); 0 (Glucosides); 0 (Glycosides); 0 (Iridoid Glucosides); 0 (Iridoids); 0 (Lignans); 14691-52-2 (Peroxynitrous Acid); 2415-24-9 (catalpol); 73XCE5OZB0 (lariciresinol); 7KD7K3964H (catalposide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00139


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[PMID]:28711487
[Au] Autor:Chen L; Yang Y; Zhang L; Li C; Coffie JW; Geng X; Qiu L; You X; Fang Z; Song M; Gao X; Wang H
[Ad] Endereço:Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, China; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
[Ti] Título:Aucubin promotes angiogenesis via estrogen receptor beta in a mouse model of hindlimb ischemia.
[So] Source:J Steroid Biochem Mol Biol;172:149-159, 2017 Sep.
[Is] ISSN:1879-1220
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Aucubin (AU) is an iridoid glycoside that has been shown to display estrogenic properties and has various pharmacological effects. Herein, we described the angiogenic properties of AU. In the study, hindlimb ischemia was induced by ligation of femoral artery on the right leg of ovariectomized mice. AU treatment significantly accelerated perfusion recovery and reduced tissue injury in mice muscle. Quantification of CD31-positive vessels in hindlimb muscles provided evidences that AU promoted angiogenesis in peripheral ischemia. In addition, results from quantitative PCR and western blot suggested AU induced angiogenesis via vascular endothelial cell growth factor (VEGF)/Akt/endothelial nitric oxide synthase (eNOS) signaling pathway. More interestingly, AU's angiogenic effects could be completely abolished in estrogen receptor beta (ERß) knockout mice. In conclusion, the underlying mechanisms were elucidated that AU produced pro-angiogenic effects through ERß-mediated VEGF signaling pathways. These results expand knowledge about the beneficial effects of AU in angiogenesis and blood flow recovery. It might provide insight into the ERß regulating neovascularisation in hindlimb ischemia and identify AU as a potent new compound used for the treatment of peripheral vascular disease.
[Mh] Termos MeSH primário: Indutores da Angiogênese/farmacologia
Receptor beta de Estrogênio/genética
Glucosídeos Iridoides/farmacologia
Isquemia/tratamento farmacológico
Neovascularização Fisiológica/efeitos dos fármacos
Fitoestrógenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Receptor beta de Estrogênio/deficiência
Feminino
Artéria Femoral/cirurgia
Regulação da Expressão Gênica
Membro Posterior
Isquemia/genética
Isquemia/patologia
Isquemia/cirurgia
Ligadura
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Óxido Nítrico Sintase Tipo III/genética
Óxido Nítrico Sintase Tipo III/metabolismo
Ovariectomia
Molécula-1 de Adesão Celular Endotelial de Plaquetas/genética
Molécula-1 de Adesão Celular Endotelial de Plaquetas/metabolismo
Proteínas Proto-Oncogênicas c-akt/genética
Proteínas Proto-Oncogênicas c-akt/metabolismo
Recuperação de Função Fisiológica/efeitos dos fármacos
Transdução de Sinais
Fator A de Crescimento do Endotélio Vascular/genética
Fator A de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inducing Agents); 0 (Estrogen Receptor beta); 0 (Iridoid Glucosides); 0 (Phytoestrogens); 0 (Platelet Endothelial Cell Adhesion Molecule-1); 0 (Vascular Endothelial Growth Factor A); 0 (vascular endothelial growth factor A, mouse); 2G52GS8UML (aucubin); EC 1.14.13.39 (Nitric Oxide Synthase Type III); EC 1.14.13.39 (Nos3 protein, mouse); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170717
[St] Status:MEDLINE


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[PMID]:28596026
[Au] Autor:He J; Ye XS; Wang XX; Yang YN; Zhang PC; Ma BZ; Zhang WK; Xu JK
[Ad] Endereço:Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, People's Republic of China.
[Ti] Título:Four new iridoid glucosides containing the furan ring from the fruit of Cornus officinalis.
[So] Source:Fitoterapia;120:136-141, 2017 Jul.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Four new and rare iridoid glucosides, cornusfuroside A-D (1-4), containing the furan ring were identified from water extract of the fruit of Cornus officinalis. These new chemical structures were determined through extensive spectroscopic analysis, including 1D and 2D NMR, IR, HRESIMS, experimental and calculated electronic circular dichroism (ECD). Notably, this study is the first report on the isolation of four iridoid glucoside structures with acetal functions in the sugar moiety. The neuroprotective effects of these compounds were also evaluated in vitro.
[Mh] Termos MeSH primário: Cornus/química
Frutas/química
Glucosídeos Iridoides/química
Fármacos Neuroprotetores/química
[Mh] Termos MeSH secundário: Animais
Glucosídeos Iridoides/isolamento & purificação
Estrutura Molecular
Fármacos Neuroprotetores/isolamento & purificação
Células PC12
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iridoid Glucosides); 0 (Neuroprotective Agents)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE


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[PMID]:28550715
[Au] Autor:Kroll-Møller P; Pedersen KD; Gousiadou C; Kokubun T; Albach D; Taskova R; Garnock-Jones PJ; Gotfredsen CH; Jensen SR
[Ad] Endereço:Department of Chemistry, The Technical University of Denmark, Build. 207, DK-2800, Lyngby, Denmark.
[Ti] Título:Iridoid glucosides in the genus Veronica (Plantaginaceae) from New Zealand.
[So] Source:Phytochemistry;140:174-180, 2017 Aug.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Four simple iridoid glucosides, three known esters of catalpol, seven esters of aucubin, and two phenylethanoids were isolated from Veronica hookeri (syn. Hebe ciliolata; Plantaginaceae). Of these, none of four aromatic (p-methoxybenzoyl, isovanilloyl, veratroyl, caffeoyl) 6-O-esters of aucubin and 6″-O-benzoyl mussaenosidic acid, had been reported from nature before. Similarly, three simple iridoid glucosides, two esters of 6-O-rhamnopyranosylcatapol, and two phenylethanoid glucosides, as well as 1-O-benzoyl-3-α-glucuronosylglycerol, and 1-O-ß-benzoyl rutinoside were isolated from Veronica pinguifolia (syn. Hebe pinguifolia). The compound 3″-O-benzoyl-2″-O-caffeoyl 6-O-rhamnopyranosylcatalpol had not been reported previously. The pattern of the structural features of the iridoid glucosides is overlaid onto the latest molecular phylogenetic framework of Veronica sects. Hebe and Labiatoides, and discussed in the context of evolutionary trends.
[Mh] Termos MeSH primário: Glucosídeos Iridoides/química
Veronica/química
[Mh] Termos MeSH secundário: Glucosídeos Iridoides/isolamento & purificação
Estrutura Molecular
Nova Zelândia
Filogenia
Veronica/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iridoid Glucosides); 2415-24-9 (catalpol); 2G52GS8UML (aucubin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170528
[St] Status:MEDLINE


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[PMID]:28441724
[Au] Autor:Kim JH; Hwang DK; Moon JY; Lee Y; Yoo JS; Shin DH; Lee HS
[Ad] Endereço:Drug Metabolism & Bioanalysis Laboratory, College of Pharmacy, The Catholic University of Korea, Bucheon 14462, Korea. jhyunkim@catholic.ac.kr.
[Ti] Título:Multiple UDP-Glucuronosyltransferase and Sulfotransferase Enzymes are Responsible for the Metabolism of Verproside in Human Liver Preparations.
[So] Source:Molecules;22(4), 2017 Apr 22.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Verproside, an active iridoid glycoside component of Veronica species, such as var. and , possesses anti-asthma, anti-inflammatory, anti-nociceptive, antioxidant, and cytostatic activities. Verproside is metabolized into nine metabolites in human hepatocytes: verproside glucuronides ( , ) via glucuronidation, verproside sulfate ( ) via sulfation, picroside II ( ) and isovanilloylcatalpol ( ) via -methylation, glucuronide ( ) and sulfate ( ) via further glucuronidation and sulfation of , and glucuronide ( ) and sulfate ( ) via further glucuronidation and sulfation of . Drug-metabolizing enzymes responsible for verproside metabolism, including sulfotransferase (SULT) and UDP-glucuronosyltransferase (UGT), were characterized. The formation of verproside glucuronides ( , ), isovanilloylcatalpol glucuronide ( ), and picroside II glucuronide ( ) was catalyzed by commonly expressed UGT1A1 and UGT1A9 and gastrointestinal-specific UGT1A7, UGT1A8, and UGT1A10, consistent with the higher intrinsic clearance values for the formation of , , , and in human intestinal microsomes compared with those in liver microsomes. The formation of verproside sulfate ( ) and sulfate ( ) from verproside and isovanilloylcatalpol ( ), respectively, was catalyzed by SULT1A1. Metabolism of picroside II ( ) into sulfate ( ) was catalyzed by SULT1A1, SULT1E1, SULT1A2, SULT1A3, and SULT1C4. Based on these results, the pharmacokinetics of verproside may be affected by the co-administration of relevant UGT and SULT inhibitors or inducers.
[Mh] Termos MeSH primário: Glucuronosiltransferase/fisiologia
Glucosídeos Iridoides/metabolismo
Microssomos Hepáticos/enzimologia
Sulfotransferases/fisiologia
[Mh] Termos MeSH secundário: Células Cultivadas
Cinamatos/metabolismo
Hepatócitos/enzimologia
Seres Humanos
Inativação Metabólica
Iridoides/metabolismo
Cinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cinnamates); 0 (Iridoid Glucosides); 0 (Iridoids); 0 (isovanilloylcatalpol); 0 (verproside); 39012-20-9 (picroside II); EC 2.4.1.17 (Glucuronosyltransferase); EC 2.8.2.- (Sulfotransferases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE



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