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[PMID]:28473297
[Au] Autor:Pochapsky TC; Wong N; Zhuang Y; Futcher J; Pandelia ME; Teitz DR; Colthart AM
[Ad] Endereço:Department of Chemistry, Brandeis University, 415 South St., Waltham, MA 02454-9110, USA. Electronic address: pochapsk@brandeis.edu.
[Ti] Título:NADH reduction of nitroaromatics as a probe for residual ferric form high-spin in a cytochrome P450.
[So] Source:Biochim Biophys Acta;1866(1):126-133, 2018 01.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The existence of a substrate-sensitive equilibrium between high spin (S=5/2) and low spin (S=1/2) ferric iron is a well-established phenomenon in the cytochrome P450 (CYP) superfamily, although its origins are still a subject of discussion. A series of mutations that strongly perturb the spin state equilibrium in the camphor hydroxylase CYP101A1 were recently described (Colthart et al., Sci. Rep. 6, 22035 (2016)). Wild type CYP101A1 as well as some CYP101A1 mutants are herein shown to be capable of catalyzing the reduction of nitroacetophenones by NADH to the corresponding anilino compounds (nitroreductase or NRase activity). The distinguishing characteristic between those mutants that catalyze the reduction and those that cannot appears to be the extent to which residual high spin form exists in the absence of the native substrate d-camphor, with those showing the largest spin state shifts upon camphor binding also exhibiting NRase activity. Optical and EPR spectroscopy was used to further examine these phenomena. These results suggest that reduction of nitroaromatics may provide a useful probe of residual high spin states in the CYP superfamily. This article is part of a Special Issue entitled: Cytochrome P450 biodiversity and biotechnology, edited by Erika Plettner, Gianfranco Gilardi, Luet Wong, Vlada Urlacher, Jared Goldstone.
[Mh] Termos MeSH primário: Acetofenonas/química
Proteínas de Bactérias/química
Cânfora 5-Mono-Oxigenase/química
Cânfora/química
Compostos Férricos/química
Heme/química
NAD/química
[Mh] Termos MeSH secundário: Acetofenonas/metabolismo
Motivos de Aminoácidos
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Sítios de Ligação
Biocatálise
Cânfora/metabolismo
Cânfora 5-Mono-Oxigenase/genética
Cânfora 5-Mono-Oxigenase/metabolismo
Clonagem Molecular
Espectroscopia de Ressonância de Spin Eletrônica
Escherichia coli/genética
Escherichia coli/metabolismo
Expressão Gênica
Heme/metabolismo
Cinética
Modelos Moleculares
NAD/metabolismo
Oxirredução
Ligação Proteica
Conformação Proteica em alfa-Hélice
Conformação Proteica em Folha beta
Domínios e Motivos de Interação entre Proteínas
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Acetophenones); 0 (Bacterial Proteins); 0 (Ferric Compounds); 0 (Recombinant Proteins); 0U46U6E8UK (NAD); 100-19-6 (4-nitroacetophenone); 42VZT0U6YR (Heme); 76-22-2 (Camphor); EC 1.14.15.1 (Camphor 5-Monooxygenase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170506
[St] Status:MEDLINE


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[PMID]:28877280
[Au] Autor:Epasinghe DJ; Yiu CKY; Burrow MF
[Ad] Endereço:Prince Philip Dental Hospital, University of Hong Kong, Faculty of Dentistry, Hong Kong SAR, China.
[Ti] Título:Mechanical properties, water sorption characteristics, and compound release of grape seed extract-incorporated resins.
[So] Source:J Appl Oral Sci;25(4):412-419, 2017 Jul-Aug.
[Is] ISSN:1678-7765
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Objective: This study evaluated the effect of grape seed extract (GSE) incorporation on the mechanical properties, water sorption, solubility, and GSE release from the experimental adhesive resins. Material and Methods: An experimental comonomer mixture, consisting of 40% Bis-GMA, 30% Bis MP, 28% HEMA, 0.26% camphorquinone and 1% EDMAB, was used to prepare four GSE-incorporated adhesive resins at concentrations of 0.5, 1, 1.5, and 2 wt%. The neat resin without GSE was used as the control. Six resin beams (25 mm x 2 mm x 2 mm) per group were prepared for flexural strength and modulus of elasticity evaluations using a universal testing machine at a crosshead speed of 1 mm/min. Five disks (6 mm in diameter and 2 mm in thickness) per group were used for microhardness measurements using a Leitz micro-hardness tester with Leica Qgo software. Five disks (7 mm in diameter and 2 mm in thickness) per group were prepared and stored in deionized water for 28 days. Water sorption, solubility, and GSE release in deionized water were calculated for each GSE-incorporated adhesive at the end of 28th day. Data was evaluated using one-way ANOVA and Tukey multiple comparisons. Results: Flexural strength, modulus of elasticity and microhardness of GSE-incorporated adhesive decreased significantly with incorporation of 1.5% of GSE (p<0.05). Addition of GSE had no effect on the water sorption of the adhesive resins (p=0.33). The solubility of the resin also increased significantly with incorporation of 1.5% of GSE (p<0.05). Quantities of GSE release increased with increased concentration of GSE in the adhesive resin. Conclusion: Up to 1% of GSE can be incorporated into a dental adhesive resin without interfering with the mechanical properties or solubility of the resins.
[Mh] Termos MeSH primário: Bis-Fenol A-Glicidil Metacrilato/química
Cânfora/análogos & derivados
Extrato de Sementes de Uva/química
Metacrilatos/química
Cimentos de Resina/química
para-Aminobenzoatos/química
[Mh] Termos MeSH secundário: Análise de Variância
Cânfora/química
Módulo de Elasticidade
Testes de Dureza
Teste de Materiais
Maleabilidade
Proantocianidinas/química
Valores de Referência
Reprodutibilidade dos Testes
Solubilidade
Estatísticas não Paramétricas
Fatores de Tempo
Água/química
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Grape Seed Extract); 0 (Methacrylates); 0 (Proanthocyanidins); 0 (Resin Cements); 0 (ethyl 4-N,N-dimethylaminobenzoate); 0 (para-Aminobenzoates); 059QF0KO0R (Water); 18206-61-6 (proanthocyanidin); 454I75YXY0 (Bisphenol A-Glycidyl Methacrylate); 6E1I4IV47V (hydroxyethyl methacrylate); 76-22-2 (Camphor); RAL3591W33 (camphorquinone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


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[PMID]:28701653
[Au] Autor:Asakawa Y; Ludwiczuk A; Sakurai K; Tomiyama K; Kawakami Y; Yaguchi Y
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Tokushima Bunri University.
[Ti] Título:Comparative Study on Volatile Compounds of Alpinia japonica and Elettaria cardamomum.
[So] Source:J Oleo Sci;66(8):871-876, 2017 Aug 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The volatile compounds obtained from the ether extracts, headspace gases and steam distillates of Alpinia japonica and Elettaria cardamomum were analyzed by GC/MS. Both species were rich sources of naturally rare fenchane-type monoterpenoids, fenchene, fenchone, fenchyl alcohol and its acetate, together with 1,8-cineole. The distributions of volatile sesquiterpenoids were very poor in both species. Chiralities of fenchone in A. japonica and E. cardamomum were 99% of (1S,4R)-(+)-form. Camphor in A. japonica is composed of a mixture of (1R,4R)-(+)-form (94.3%) and (1S,4S)-(-)-form (5.7%). On the other hand, E. cardamomum produced only (1R,4R)-(+)-camphor (99%).
[Mh] Termos MeSH primário: Alpinia/química
Elettaria/química
Monoterpenos/análise
Extratos Vegetais/química
Sesquiterpenos/análise
Compostos Orgânicos Voláteis/análise
[Mh] Termos MeSH secundário: Cânfora/análise
Cicloexanóis/análise
Éter
Cromatografia Gasosa-Espectrometria de Massas
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclohexanols); 0 (Monoterpenes); 0 (Plant Extracts); 0 (Sesquiterpenes); 0 (Volatile Organic Compounds); 0F5N573A2Y (Ether); 76-22-2 (Camphor); RV6J6604TK (eucalyptol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17048


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[PMID]:28655616
[Au] Autor:Hurd MC; Kwon M; Ro DK
[Ad] Endereço:University of Calgary, Department of Biological Sciences, Calgary, AB, T2N 1N4, Canada.
[Ti] Título:Functional identification of a Lippia dulcis bornyl diphosphate synthase that contains a duplicated, inhibitory arginine-rich motif.
[So] Source:Biochem Biophys Res Commun;490(3):963-968, 2017 Aug 26.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lippia dulcis (Aztec sweet herb) contains the potent natural sweetener hernandulcin, a sesquiterpene ketone found in the leaves and flowers. Utilizing the leaves for agricultural application is challenging due to the presence of the bitter-tasting and toxic monoterpene, camphor. To unlock the commercial potential of L. dulcis leaves, the first step of camphor biosynthesis by a bornyl diphosphate synthase needs to be elucidated. Two putative monoterpene synthases (LdTPS3 and LdTPS9) were isolated from L. dulcis leaf cDNA. To elucidate their catalytic functions, E. coli-produced recombinant enzymes with truncations of their chloroplast transit peptides were assayed with geranyl diphosphate (GPP). In vitro enzyme assays showed that LdTPS3 encodes bornyl diphosphate synthase (thus named LdBPPS) while LdTPS9 encodes linalool synthase. Interestingly, the N-terminus of LdBPPS possesses two arginine-rich (RRX W) motifs, and enzyme assays showed that the presence of both RRX W motifs completely inhibits the catalytic activity of LdBPPS. Only after the removal of the putative chloroplast transit peptide and the first RRX W, LdBPPS could react with GPP to produce bornyl diphosphate. LdBPPS is distantly related to the known bornyl diphosphate synthase from sage in a phylogenetic analysis, indicating a converged evolution of camphor biosynthesis in sage and L. dulcis. The discovery of LdBPPS opens up the possibility of engineering L. dulcis to remove the undesirable product, camphor.
[Mh] Termos MeSH primário: Cânfora/metabolismo
Liases Intramoleculares/metabolismo
Lippia/enzimologia
Sesquiterpenos/metabolismo
[Mh] Termos MeSH secundário: Motivos de Aminoácidos
Sequência de Aminoácidos
Arginina/química
Arginina/metabolismo
Liases Intramoleculares/química
Liases Intramoleculares/genética
Lippia/química
Lippia/genética
Lippia/metabolismo
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sesquiterpenes); 76-22-2 (Camphor); 7V22TJL7NX (hernandulcin); 94ZLA3W45F (Arginine); EC 5.5.- (Intramolecular Lyases); EC 5.5.1.8 (geranyl-diphosphate cyclase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE


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[PMID]:28554026
[Au] Autor:Campos D; Gravato C; Fedorova G; Burkina V; Soares AMVM; Pestana JLT
[Ad] Endereço:Departamento de Biologia & CESAM, Universidade de Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.
[Ti] Título:Ecotoxicity of two organic UV-filters to the freshwater caddisfly Sericostoma vittatum.
[So] Source:Environ Pollut;228:370-377, 2017 Sep.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Organic ultraviolet filters (UV-filters) used for protection against radiation in personal care products and other materials (e.g. textiles, plastic products) are considered emerging contaminants of aquatic ecosystem. Benzophenone-3 (BP3) and 3-(4-methylbenzylidene)camphor (4-MBC) are the most commonly used organic UV-filters and have been reported in freshwater environments due to contamination through discharges from wastewater treatment plants and swimming pools or by direct contamination from recreational activities. Our aim was to evaluate the ecotoxicological effects of these UV-filters using the freshwater caddisfly Sericostoma vittatum' biochemical biomarkers and energy processing related endpoints (feeding behaviour, energy reserves and cellular metabolism). In laboratory trials, both compounds induced feeding inhibition of S. vittatum at 3.55 mg/kg of BP3 and at concentrations ≥2.57 mg/kg of 4-MBC, decreased carbohydrates content at 3.55 and 6.95 mg/kg of BP3 and 4-MBC respectively, and increased total glutathione levels at concentrations ≥1.45 and 1.35 mg/kg of BP3 and 4-MBC respectively. No significant effects were observed on endpoints associated with oxidative stress, antioxidant defences, phase II biotransformation or neurotoxicity after exposure to the two UV-filters. Our results show that environmental relevant concentrations of BP3 and 4-MBC, can negatively impact freshwater insects and demonstrate the importance of monitoring the ecological effects of organic UV-filters using non-model invertebrate species.
[Mh] Termos MeSH primário: Insetos/fisiologia
Protetores Solares/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Benzofenonas/toxicidade
Cânfora/análogos & derivados
Cânfora/toxicidade
Água Doce
Piscinas
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzophenones); 0 (Sunscreening Agents); 0 (Water Pollutants, Chemical); 76-22-2 (Camphor); 8I3XWY40L9 (enzacamene); 95OOS7VE0Y (oxybenzone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE


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[PMID]:28551578
[Au] Autor:Campos D; Gravato C; Quintaneiro C; Golovko O; Zlábek V; Soares AMVM; Pestana JLT
[Ad] Endereço:Departamento de Biologia & CESAM, Universidade de Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.
[Ti] Título:Toxicity of organic UV-filters to the aquatic midge Chironomus riparius.
[So] Source:Ecotoxicol Environ Saf;143:210-216, 2017 Sep.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Despite the frequent detection of organic ultraviolet-filters (UV-filters) in freshwater sediments, there is a lack of ecotoxicological data undermining a correct risk assessment for these emerging contaminants. The present study assessed the effects of three of the most commonly used UV-filters (benzophenone-3 - BP3; 3-(4-methylbenzylidene)camphor - 4-MBC and octocrylene - OC) on Chironomus riparius life history and biochemical responses. Standard ecotoxicological assays confirmed that all compounds impaired growth of C. riparius larvae and induced developmental effects such as delayed emergence and a reduction of imagoes weight. Concerning the biochemical responses analysed no evidences of oxidative damage in lipids or neurotoxicity (tested assessing acetylcholinesterase activity) were observed for any of the tested compounds. However, 4-MBC exposure induced a decrease in catalase activity and an increase in glutathione-S-transferase activity at 14.13mg/Kg while OC exposure caused an increase in total glutathione levels at 0.23 and 18.23mg/Kg. Exposure to all UV-filters tested, increased energy consumption on C. riparius with significant differences above 1.00mg/Kg for BP3, 0.09mg/Kg for 4-MBC and 2.13mg/Kg for OC. These results suggest that environmental relevant concentrations of UV-filters can cause deleterious effects to aquatic benthic species, such as C. riparius, and call for further research concerning effects of organic UV-filters on natural invertebrate communities and ecosystem functioning.
[Mh] Termos MeSH primário: Acrilatos/toxicidade
Benzofenonas/toxicidade
Cânfora/análogos & derivados
Chironomidae/efeitos dos fármacos
Protetores Solares/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Animais
Cânfora/toxicidade
Catalase/metabolismo
Chironomidae/enzimologia
Feminino
Glutationa Transferase/metabolismo
Larva/efeitos dos fármacos
Larva/enzimologia
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylates); 0 (Benzophenones); 0 (Sunscreening Agents); 0 (Water Pollutants, Chemical); 5A68WGF6WM (octocrylene); 76-22-2 (Camphor); 8I3XWY40L9 (enzacamene); 95OOS7VE0Y (oxybenzone); EC 1.11.1.6 (Catalase); EC 2.5.1.18 (Glutathione Transferase); EC 3.1.1.7 (Acetylcholinesterase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170529
[St] Status:MEDLINE


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[PMID]:28541143
[Au] Autor:Moss MJ; Maskell KF; Hieger MA; Wills BK; Cumpston KL
[Ad] Endereço:a Department of Emergency Medicine , VCU Medical Center , Richmond , VA , USA.
[Ti] Título:An algorithm for identifying mothball composition .
[So] Source:Clin Toxicol (Phila);55(8):919-921, 2017 Sep.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Unintentional mothball ingestions may cause serious toxicity in small children. Camphor, naphthalene, and paradichlorobenzene mothballs are difficult to distinguish without packaging. Symptoms and management differ based on the ingested compound. Previous studies have used a variety of antiquated, impractical and potentially dangerous techniques to identify the mothballs. The goal of this study is to discover a simplified identification technique using materials readily available in an emergency department. METHODS: Mothballs made of naphthalene and paradichlorobenzene along with camphor tablets were tested. Each material was tested both intact and after being fragmented to simulate a partially ingested mothball. Each of these six sample types were then immersed in 40 ml each of 11 fluids: water, 0.45% NaCl, 0.9% NaCl, lactated Ringer's, 5% dextrose in water, 5% dextrose in 0.9% NaCl, 50% dextrose in water, 8.4% NaHCO , 3% H O , 70% isopropanol, and 91% isopropanol. All tests were conducted in standard urinalysis sample cups to replicate available materials. Three toxicologists blinded to the identities of samples and solutions visually evaluated each sample. Observations included assessing response to immersion: sink, float, or dissolve. RESULTS: All evaluators agreed in their description of 62/66 (94%) of the samples, with all four disagreements being on sinking and dissolving versus sinking only. A two-fluid algorithm utilizing 50% dextrose and water was sufficient to distinguish the sample types. Camphor will float in water while both paradichlorobenzene and naphthalene will sink. In 50% dextrose, both naphthalene and camphor will float while paradichlorobenzene will sink. CONCLUSION: Mothball materials can be distinguished by immersion in water and 50% dextrose. Limitations of this study include using camphor tablets as a substitute for mothballs given lack of availability.
[Mh] Termos MeSH primário: Algoritmos
Cânfora/análise
Clorobenzenos/análise
Glucose/química
Repelentes de Insetos/análise
Mariposas
Naftalenos/análise
Água/química
[Mh] Termos MeSH secundário: Animais
Cânfora/envenenamento
Clorobenzenos/envenenamento
Liberação Controlada de Fármacos
Repelentes de Insetos/envenenamento
Naftalenos/envenenamento
Variações Dependentes do Observador
Reprodutibilidade dos Testes
Solubilidade
Gravidade Específica
Comprimidos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorobenzenes); 0 (Insect Repellents); 0 (Naphthalenes); 0 (Tablets); 059QF0KO0R (Water); 2166IN72UN (naphthalene); 76-22-2 (Camphor); D149TYB5MK (4-dichlorobenzene); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1080/15563650.2017.1319954


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[PMID]:28381772
[Au] Autor:Marumoto S; Okuno Y; Miyazawa M
[Ad] Endereço:Joint Research Center, Kindai University (Former name: Kinki University).
[Ti] Título:Inhibition of ß-Secretase Activity by Monoterpenes, Sesquiterpenes, and C Norisoprenoids.
[So] Source:J Oleo Sci;66(8):851-855, 2017 Aug 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Inhibition of ß-secretase (BACE1) is currently regarded as the leading treatment strategy for Alzheimer's disease. In the present study, we aimed to screen the in vitro inhibitory activity of 80 types of aroma compounds (monoterpenes, sesquiterpenes, and C norisoprenoids), including plant-based types, at a 200-µM concentration against a recombinant human BACE1. The results showed that the most potent inhibitor of BACE1 was geranyl acetone followed by (+)-camphor, (-)-fenchone, (+)-fenchone, and (-)-camphor with the half-maximal inhibitory concentration (IC ) values of 51.9 ± 3.9, 95.9 ± 11.0, 106.3 ± 14.9, 117.0 ± 18.6, and 134.1 ± 16.4 µM, respectively. Furthermore, the mechanism of inhibition of BACE1 by geranyl acetone was analyzed using Dixon kinetics plus Cornish-Bowden plots, which revealed mixed-type mode. Therefore aroma compounds may be used as potential lead molecules for designing anti-BACE1 agents.
[Mh] Termos MeSH primário: Secretases da Proteína Precursora do Amiloide/antagonistas & inibidores
Inibidores Enzimáticos/farmacologia
Monoterpenos/farmacologia
Norisoprenoides/farmacologia
Sesquiterpenos/farmacologia
[Mh] Termos MeSH secundário: Doença de Alzheimer/tratamento farmacológico
Doença de Alzheimer/enzimologia
Doença de Alzheimer/etiologia
Cânfora/farmacologia
Cânfora/uso terapêutico
Relação Dose-Resposta a Droga
Descoberta de Drogas
Inibidores Enzimáticos/uso terapêutico
Seres Humanos
Técnicas In Vitro
Terapia de Alvo Molecular
Monoterpenos/uso terapêutico
Norbornanos/farmacologia
Norbornanos/uso terapêutico
Fitoterapia
Proteínas Recombinantes
Terpenos/farmacologia
Terpenos/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Monoterpenes); 0 (Norbornanes); 0 (Norisoprenoids); 0 (Recombinant Proteins); 0 (Sesquiterpenes); 0 (Terpenes); 1195-79-5 (fenchone); 76-22-2 (Camphor); 9B7RY79U9Z (geranylacetone); EC 3.4.- (Amyloid Precursor Protein Secretases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess16188


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[PMID]:28378196
[Au] Autor:Tabari MA; Youssefi MR; Benelli G
[Ad] Endereço:Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran.
[Ti] Título:Eco-friendly control of the poultry red mite, Dermanyssus gallinae (Dermanyssidae), using the α-thujone-rich essential oil of Artemisia sieberi (Asteraceae): toxic and repellent potential.
[So] Source:Parasitol Res;116(5):1545-1551, 2017 May.
[Is] ISSN:1432-1955
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The poultry red mite, Dermanyssus gallinae, represents a key threat for the poultry industry worldwide. The control of D. gallinae is mainly achieved by continuous applications of acaricides. However, the fast-growing development of resistance, and the strict laws concerning chemicals admitted for treatments on food animals, highlighted the importance of alternative control tools. Here, we explored the potential of Artemisia sieberi essential oil against D. gallinae. In this study, the A. sieberi essential oil was analyzed using GC and GC-MS. The oil toxicity through contact and fumigant assays on adult mites was evaluated. The oil repellent activity was assessed on adult mites over different time intervals. Lastly, the residual toxicity of various doses of the oil was evaluated on D. gallinae until 14 days post treatment. GC and GC-MS showed that the oil was rich in α-thujone (31.5%), ß-thujone (11.92%), camphor (12.3%), and 1,8-cineole (10.09%). Contact toxicity on adult mites showed 50% lethal concentration (LC ), LC , and LC of 15.85, 26.63, and 35.42 µg/cm , respectively. In fumigant assays, the oil was toxic on D. gallinae, and mortality was significantly higher in open containers over closed ones, underlining the key role of highly volatile constituents. Repellent assays showed that after 24 h from the treatment, all doses of the A. sieberi essential oil led to significant repellent activity over the control, except for 2 µg/cm . After 48 h, A. sieberi essential oil tested at all doses led to significant repellent activity, if compared to the control. Residual toxicity assays showed that time exposure and concentration tested had a significant impact on mite mortality after 1, 2, 5, and 7 days from the treatment. Notably, mortality remained significantly higher over the control for 7 days after spraying with oil at 2%. Further field assays with selected molecules from the A. sieberi essential oil are ongoing, testing them in synergistic blends, as well as in microencapsulated formulations.
[Mh] Termos MeSH primário: Acaricidas/farmacologia
Artemisia/química
Repelentes de Insetos/farmacologia
Inseticidas/farmacologia
Óleos Voláteis/análise
Óleos Voláteis/farmacologia
Trombiculidae/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Cânfora/química
Cicloexanóis/química
Resistência a Medicamentos
Cromatografia Gasosa-Espectrometria de Massas
Repelentes de Insetos/química
Inseticidas/química
Monoterpenos/química
Óleos Voláteis/química
Aves Domésticas/parasitologia
Trombiculidae/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Cyclohexanols); 0 (Insect Repellents); 0 (Insecticides); 0 (Monoterpenes); 0 (Oils, Volatile); 76-22-2 (Camphor); 8ZI5R3T54Q (beta-thujone); RV6J6604TK (eucalyptol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1007/s00436-017-5431-0


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[PMID]:28366530
[Au] Autor:Artyushin OI; Sharova EV; Vinogradova NM; Genkina GK; Moiseeva AA; Klemenkova ZS; Orshanskaya IR; Shtro AA; Kadyrova RA; Zarubaev VV; Yarovaya OI; Salakhutdinov NF; Brel VK
[Ad] Endereço:A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, 28, Vavilova St., GSP-1, V-334, 119991 Moscow, Russian Federation.
[Ti] Título:Synthesis of camphecene derivatives using click chemistry methodology and study of their antiviral activity.
[So] Source:Bioorg Med Chem Lett;27(10):2181-2184, 2017 05 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A series of seventeen tetrazole derivatives of 1,7,7-trimethyl-[2.2.1]bicycloheptane were synthesized using click chemistry methodology and characterized by spectral data. Studies of cytotoxicity and in vitro antiviral activity against influenza virus A/Puerto Rico/8/34 (H1N1) in MDCK cells of the compounds obtained were performed. The structure-activity relationship analysis suggests that to possess virus-inhibiting activity, the compounds of this group should bear oxygen atom with a short linker (C2-C4), either as a hydroxyl group (18, 19, 29), keto-group (21) or as a part of a heterocycle (24). These compounds demonstrated low cytotoxicity along with high anti-viral activity.
[Mh] Termos MeSH primário: Antivirais/síntese química
Cânfora/análogos & derivados
Etanolaminas/química
[Mh] Termos MeSH secundário: Animais
Antivirais/química
Antivirais/farmacologia
Cânfora/síntese química
Cânfora/química
Cânfora/farmacologia
Química Click
Cães
Etanolaminas/síntese química
Etanolaminas/farmacologia
Seres Humanos
Vírus da Influenza A Subtipo H1N1/efeitos dos fármacos
Células Madin Darby de Rim Canino
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Ethanolamines); 0 (camphecene); 76-22-2 (Camphor)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE



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