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  1 / 1956 MEDLINE  
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[PMID]:29257630
[Au] Autor:Saylor Ö
[Ti] Título:Toxic effects of permethrin on Pseudorasbora parva.
[So] Source:J Environ Biol;37(6):1247-53, 2016 Nov.
[Is] ISSN:0254-8704
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:The present study deals with acute toxicity and hematological, histopathological and genotoxical effects of permethrin, a synthetic pyrethroid, on Pseudorasbora parva. Acute toxicity of 96-hrs LC50 value was found to be 88.25 (84.60-92.63) µgl-1. Sublethal dose was taken as 8.82 µgl-1 (the 1/10 of the LC50 value) in bio-experiments. Micronucleus changes in blood erythrocyte and hemotocyte level in P. parva exposed to sub-lethal concentration were investigated. Difference between nucleolus abnormalities in the experimental and control group was found to be statistically significant (t-test). Micronucleus frequency was found to be 8.26. The hematocrit level in control and experimental groups were found to be 24.43% and 14.673%. No pathological symptoms were observed in the muscle of P. parva exposed to sublethal dose for 96 hrs. Pathological symptoms observed after 96 hours from permethrin administration in other organs were: Fusion, Telangiectasis, epithelial lifting and hyperemia in gills; hydropic degeneration, lipid degeneration and passive hyperemia in liver and enlargement of cavum glomeruli and Bowman space in kidneys and hemorrhage, edema and hyperemia in brain, respectively.
[Mh] Termos MeSH primário: Cyprinidae
Inseticidas/toxicidade
Permetrina/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Encéfalo/efeitos dos fármacos
Encéfalo/patologia
Brânquias/efeitos dos fármacos
Brânquias/patologia
Espécies Introduzidas
Rim/efeitos dos fármacos
Rim/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Water Pollutants, Chemical); 509F88P9SZ (Permethrin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


  2 / 1956 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:29186253
[Au] Autor:Lima FCDR; Cerqueira AMM; Guimarães MBS; Padilha CBS; Craide FH; Bombardelli M
[Ad] Endereço:Dermatology Service of the General Polyclinic of Rio de Janeiro (PGRJ) - Rio de Janeiro (RJ), Brazil.
[Ti] Título:Crusted scabies due to indiscriminate use of glucocorticoid therapy in infant.
[So] Source:An Bras Dermatol;92(3):383-385, 2017 May-Jun.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Crusted or Norwegian scabies is a parasitic infectious disease caused by Sarcoptes scabiei var. hominis that mainly affects immunocompromised individuals and those with neurological patients. We report a case of crusted scabies in a 4-month-old infant who had been treated erroneously for atopic dermatitis with high doses of corticosteroids. This initial misdiagnosis associated with the abusive use of corticosteroid facilitated the evolution of scabies to crusted scabies and its main complications of secondary infection and sepsis.
[Mh] Termos MeSH primário: Glucocorticoides/efeitos adversos
Permetrina/uso terapêutico
Escabiose/diagnóstico
Escabiose/tratamento farmacológico
Sepse/etiologia
[Mh] Termos MeSH secundário: Adolescente
Erros de Diagnóstico
Evolução Fatal
Seres Humanos
Hospedeiro Imunocomprometido
Lactente
Masculino
Escabiose/complicações
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Glucocorticoids); 509F88P9SZ (Permethrin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE


  3 / 1956 MEDLINE  
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[PMID]:29253003
[Au] Autor:Hamid PH; Prastowo J; Ghiffari A; Taubert A; Hermosilla C
[Ad] Endereço:Department of Parasitology, Universitas Gadjah Mada, Karangmalang, Yogyakarta, Indonesia.
[Ti] Título:Aedes aegypti resistance development to commonly used insecticides in Jakarta, Indonesia.
[So] Source:PLoS One;12(12):e0189680, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aedes aegypti is the primary vector of various relevant arthropod-borne viral infectious diseases worldwide. The mosquito control is still mainly performed by using insecticides but their effectiveness is increasingly questioned nowadays. We here conducted a study on Ae. aegypti resistance development towards several commonly used insecticides in the capital city of Jakarta, Indonesia. In order to achieve this goal, Ae. aegypti eggs from Jakarta were collected with ovitraps and hatched in the insectary of the Gadjah Mada University, Indonesia. The F0 generations were used for WHO resistance tests and knockdown resistance (kdr) assays. Presented results clearly showed that there was resistance development of Ae. aegypti populations to the here tested pyrethroid insecticides (i. e. permethrin). Observed mortalities were less than 90% with highest resistance against 0.75% permethrin concentrations. Furthermore, a significant association of V1016G gene mutations with resistance phenotypes to 0.75% permethrin was observed. Nevertheless, the F1534C mutation did not show a significant correlation to resistance development. In conclusion, our results show that populations of Ae. aegypti mosquitoes within the city of Jakarta have developed resistance against several routinely used pyrethroid insecticides in local performed control programs. Thus, the regular verification/assessment of resistance development status will hopefully help in the future to assist local public health authorities in their mosquito control programs by recommending and managing the rotation of different routinely used insecticides with diverse effector mechanisms in order to delay Ae. aegypti resistance development.
[Mh] Termos MeSH primário: Aedes/genética
Resistência a Inseticidas/genética
Inseticidas
Controle de Mosquitos/métodos
[Mh] Termos MeSH secundário: Alelos
Animais
Bioensaio
Genótipo
Indonésia
Mutação/efeitos dos fármacos
Permetrina
Fenótipo
Reação em Cadeia da Polimerase
Piretrinas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Pyrethrins); 509F88P9SZ (Permethrin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189680


  4 / 1956 MEDLINE  
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[PMID]:28454576
[Au] Autor:Chatzis MK; Psemmas D; Papadopoulos E; Navarro C; Saridomichelakis MN
[Ad] Endereço:Clinic of Medicine, Faculty of Veterinary Science, University of Thessaly, 224 Trikalon Str., GR-43132, Karditsa, Greece.
[Ti] Título:A field trial of a fixed combination of permethrin and fipronil (Effitix ) for the treatment and prevention of flea infestation in dogs living with sheep.
[So] Source:Parasit Vectors;10(1):212, 2017 Apr 28.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A large number of fleas parasitize dogs living with sheep in Greece. The primary aim of this randomized, blinded, placebo-controlled trial was to examine the efficacy of a permethrin-fipronil combination (Effitix ) for the treatment and prevention of flea infestation in dogs living with sheep and the secondary aim was to examine the efficacy of this intervention on flea infestation, pruritus and skin lesions of the people in contact with these dogs. METHODS: Thirty dogs living with sheep and infested by at least 10 fleas and all 80 sheep living on the same premises were randomly allocated into equal groups. Group A dogs were treated three times, every 4 weeks, with a spot-on containing 54.5% permethrin and 6.1% fipronil, group A sheep were treated, on the same days, with a pour-on containing 1% deltamethrin, whereas group B dogs were sham-treated and group B sheep were placebo-treated. Flea counting was performed at the beginning of the trial (day 0) and after 14, 28, 56 and 84 days and the first five fleas from each animal were used for species identification. At the same time points, flea infestation, pruritus and skin lesions of the people in contact with the dogs were assessed. RESULTS: The percentage of dogs with zero flea counts was significantly higher in group A than in group B on days 14, 28, 56 and 84 and flea counts were significantly lower in group A dogs than in group B dogs at the same time points. The percent efficacy of the permethrin-fipronil combination was higher than 78% (arithmetic means) or than 96% (geometric means) throughout the study. No adverse reactions were recorded. Between the two flea species found on dogs, Ctenocephalides canis was predominant over C. felis. Flea-infected sheep were not found at the beginning or during the study and no significant changes in flea infestation, pruritus and skin lesions of the people in contact with the dogs were witnessed throughout the study. CONCLUSIONS: A spot-on solution containing 54.5% permethrin and 6.1% fipronil is safe and effective for the treatment and prevention of C. canis and C. felis infestations in dogs living with sheep.
[Mh] Termos MeSH primário: Transmissão de Doença Infecciosa/prevenção & controle
Doenças do Cão/tratamento farmacológico
Infestações por Pulgas/veterinária
Inseticidas/administração & dosagem
Permetrina/administração & dosagem
Pirazóis/administração & dosagem
Doenças dos Ovinos/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Doenças do Cão/prevenção & controle
Cães
Combinação de Medicamentos
Infestações por Pulgas/tratamento farmacológico
Infestações por Pulgas/patologia
Infestações por Pulgas/prevenção & controle
Grécia
Seres Humanos
Inseticidas/efeitos adversos
Carga Parasitária
Permetrina/efeitos adversos
Placebos/administração & dosagem
Pirazóis/efeitos adversos
Ovinos
Doenças dos Ovinos/prevenção & controle
Resultado do Tratamento
Zoonoses/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Insecticides); 0 (Placebos); 0 (Pyrazoles); 509F88P9SZ (Permethrin); QGH063955F (fipronil)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-017-2145-1


  5 / 1956 MEDLINE  
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[PMID]:28772355
[Au] Autor:Zhang Q; Zhang Y; Du J; Zhao M
[Ad] Endereço:Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang, 310032, China.
[Ti] Título:Environmentally relevant levels of λ-cyhalothrin, fenvalerate, and permethrin cause developmental toxicity and disrupt endocrine system in zebrafish (Danio rerio) embryo.
[So] Source:Chemosphere;185:1173-1180, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Synthetic pyrethroids (SPs) are one of the most widely used pesticides and frequently detected in the aquatic environment. Previous studies have shown that SPs posed high aquatic toxicity, but information on the developmental toxicity and endocrine disruption on zebrafish (Danio rerio) at environmentally relevant concentrations is limited. In this study, zebrafish embryos were employed to examine the adverse effects of λ-cyhalothrin (LCT), fenvalerate (FEN), and permethrin (PM) at 2.5, 10, 25, 125, 500 nM for 96 h. The results showed these 3 SPs caused dose-dependent mortality, malformation rate, and hatching rate. Thyroid hormone triiodothyronine (T ) levels were significantly decreased after exposure to LCT and FEN. Quantitative real-time PCR analysis was then performed on a series of nuclear receptors (NRs) genes involved in the hypothalamic-pituitary-gonadal (HPG), hypothalamic-pituitary-thyroid (HPT), hypothalamic-pituitary-adrenocortical (HPA) axes, and oxidative-stress-related system. Our results showed that LCT, FEN, and PM downregulated AR expression while upregulated ER1 expression, and caused alteration to ER2a and ER2b expression. As for the expression of TRα and TRß, they were both decreased following exposure to the 3 SPs. LCT and PM downregulated the MR expression and FEN induced MR expression. In addition, the expression of GR was increased after treating with LCT, while it was suppressed after exposure to FEN and PM. The 3 SPs also caused various alterations to the expression of genes including AhRs, PPARα, and PXR. These findings suggest that these 3 SPs may cause developmental toxicity to zebrafish larvae by disrupting endocrine signaling at environmentally relevant concentrations.
[Mh] Termos MeSH primário: Disruptores Endócrinos/toxicidade
Inseticidas/toxicidade
Nitrilos/toxicidade
Permetrina/toxicidade
Piretrinas/toxicidade
[Mh] Termos MeSH secundário: Animais
Embrião não Mamífero/efeitos dos fármacos
Sistema Endócrino/efeitos dos fármacos
Hipotálamo/metabolismo
Larva/efeitos dos fármacos
Permetrina/metabolismo
Hipófise/efeitos dos fármacos
Glândula Tireoide/efeitos dos fármacos
Hormônios Tireóideos/metabolismo
Tri-Iodotironina/metabolismo
Peixe-Zebra/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Endocrine Disruptors); 0 (Insecticides); 0 (Nitriles); 0 (Pyrethrins); 0 (Thyroid Hormones); 06LU7C9H1V (Triiodothyronine); 509F88P9SZ (Permethrin); V0V73PEB8M (cyhalothrin); Z6MXZ39302 (fenvalerate)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE


  6 / 1956 MEDLINE  
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[PMID]:28759566
[Au] Autor:Porciani A; Diop M; Moiroux N; Kadoke-Lambi T; Cohuet A; Chandre F; Dormont L; Pennetier C
[Ad] Endereço:MiVEGEC (UM1-UM2-CNRS 5290-IRD 224), Institut de Recherche pour le Développement (IRD) Cotonou, Bénin.
[Ti] Título:Influence of pyrethroïd-treated bed net on host seeking behavior of Anopheles gambiae s.s. carrying the kdr allele.
[So] Source:PLoS One;12(7):e0164518, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The use of long lasting insecticide nets (LLINs) treated with pyrethroïd is known for its major contribution in malaria control. However, LLINs are suspected to induce behavioral changes in malaria vectors, which may in turn drastically affect their efficacy against Plasmodium sp. transmission. In sub Saharan Africa, where malaria imposes the heaviest burden, the main malaria vectors are widely resistant to pyrethroïds, the insecticide family used on LLINs, which also threatens LLIN efficiency. There is therefore a crucial need for deciphering how insecticide-impregnated materials might affect the host-seeking behavior of malaria vectors in regards to insecticide resistance. In this study, we explored the impact of permethrin-impregnated net on the host attractiveness for Anopheles gambiae mosquitoes, either susceptible to insecticides, or carrying the insecticide resistance conferring allele kdr. Groups of female mosquitoes were released in a dual-choice olfactometer and their movements towards an attractive odor source (a rabbit) protected by insecticide-treated (ITN) or untreated nets (UTN) were monitored. Kdr homozygous mosquitoes, resistant to insecticides, were more attracted by a host behind an ITN than an UTN, while the presence of insecticide on the net did not affect the choice of susceptible mosquitoes. These results suggest that permethrin-impregnated net is detectable by malaria vectors and that the kdr mutation impacts their response to a LLIN protected host. We discuss the implication of these results for malaria vector control.
[Mh] Termos MeSH primário: Anopheles/efeitos dos fármacos
Comportamento de Busca por Hospedeiro
Mosquiteiros Tratados com Inseticida
Inseticidas/administração & dosagem
Piretrinas/administração & dosagem
[Mh] Termos MeSH secundário: Alelos
Animais
Anopheles/genética
Anopheles/parasitologia
Feminino
Genótipo
Heterozigoto
Resistência a Inseticidas/genética
Malária/prevenção & controle
Masculino
Controle de Mosquitos/métodos
Mutação
Permetrina/farmacologia
Fenótipo
Plasmodium
Coelhos
Olfato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Pyrethrins); 509F88P9SZ (Permethrin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0164518


  7 / 1956 MEDLINE  
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Malm, Olaf
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[PMID]:28672725
[Au] Autor:Parente CET; Lestayo J; Guida YS; Azevedo-Silva CE; Torres JPM; Meire RO; Malm O
[Ad] Endereço:Laboratório de Radioisótopos, Instituto de Biofísica, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro. Av. Carlos Chagas Filho S/n, Bloco G, Sala 60, Subsolo, Cidade Universitária, Rio de Janeiro 21941-902, Brazil. Electronic address: cparente@biof.ufrj.br.
[Ti] Título:Pyrethroids in chicken eggs from commercial farms and home production in Rio de Janeiro: Estimated daily intake and diastereomeric selectivity.
[So] Source:Chemosphere;184:1261-1269, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, pyrethroids were determined in chicken eggs from commercial farm (n = 60) and home egg production (n = 30). These pyrethroids were investigated: bifenthrin, phenothrin, permethrin, cyfluthrin, cypermethrin and fenvalerate, including most diastereomers. Quantification was done using GC-MS in a negative chemical ionization mode. Pyrethroids residues were found in 79% of the analyzed samples. Cypermethrin presented the highest occurrence, being quantified in 62 samples (69%) in concentrations (lipid weight - l w.) varying between 0.29 and 6408 ng g , followed by phenothrin (24%), 21-3910 ng g , permethrin (14%), 2.96-328 ng g , and bifenthrin (11%), 3.77-16.7 ng g . Cyfluthrin and fenvalerate were not detected. Home-produced eggs had a higher occurrence of pyrethroids (97%), with a greater predominance of phenothrin. In commercial production, 70% of the samples presented pyrethroid residues (predominantly cypermethrin). This is the first report about the presence of pyrethroids in home-produced eggs and the first description of a selectivity pattern with the predominance of cis diastereomers in chicken eggs. In general, estimated daily intake does not present a risk to human consumption, according to Brazilian and international standards (FAO/WHO). However, one third of the samples (30 eggs) had concentrations above the maximum residue limits (MRLs). The maximum cypermethrin concentration was 66 times the MRL, while the maximum phenothrin concentration was 11 times the limit. Further studies about transfer dynamics, bioaccumulation and metabolic degradation of stereoisomers are required, as well as determining if this selectivity pattern in food can increase consumer's health risk.
[Mh] Termos MeSH primário: Ovos/análise
Exposição Ambiental/estatística & dados numéricos
Fazendas
Inseticidas/análise
Piretrinas/análise
[Mh] Termos MeSH secundário: Animais
Brasil
Galinhas/metabolismo
Dieta/estatística & dados numéricos
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Nitrilos
Permetrina/análise
Piretrinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Nitriles); 0 (Pyrethrins); 1TR49121NP (cypermethrin); 509F88P9SZ (Permethrin); 6B66JED0KN (bifenthrin); 707484X33X (phenothrin); SCM2QLZ6S0 (cyfluthrin); Z6MXZ39302 (fenvalerate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE


  8 / 1956 MEDLINE  
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[PMID]:28651172
[Au] Autor:Hooshfar S; Gullick DR; Linzey MR; Mortuza T; Abdel Rahman MH; Rogers CA; Bruckner JV; White CA; Bartlett MG
[Ad] Endereço:Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602-2352, United States.
[Ti] Título:Simultaneous determination of cis-permethrin and trans-permethrin in rat plasma and brain tissue using gas chromatography-negative chemical ionization mass spectrometry.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1060:291-299, 2017 Aug 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A sensitive method for the simultaneous determination of cis-permethrin (cis-PERM) and trans-permethrin (trans-PERM) in small volumes (100µL) of rat plasma and brain homogenate was developed, using a liquid-liquid extraction for sample preparation and gas chromatography-negative chemical ionization mass spectrometry (GCNCI-MS) for detection. Quantitation of trace levels of the insecticide in small volumes of biological samples is essential to support toxicokinetic studies in small animals. There are currently no validated methods in the literature for determining cis-PERM and trans- PERM in volumes as low as 100µL of rat plasma or brain homogenate. The method provided a linear range of 0.2-150.0ng/mL for analytes in both matrices. The intra- and inter-batch precision (as% relative standard deviation, RSD) and accuracy (as relative error, RE) of the method were better than 20% at the limit of quantitation and better than 15% across the remaining linear range. The validated method was applied in a toxicokinetic study in adult rats with oral dosing of 10mg/kg (cis-PERM) and 100mg/kg (trans-PERM) in corn oil. cis-PERM and trans- PERM were monitored in rat plasma and brain tissue samples for 6h following dosing, and both analytes were detected in all plasma and brain samples.
[Mh] Termos MeSH primário: Química Encefálica/fisiologia
Cromatografia Gasosa-Espectrometria de Massas/métodos
Permetrina/análise
[Mh] Termos MeSH secundário: Animais
Modelos Lineares
Extração Líquido-Líquido/métodos
Masculino
Permetrina/sangue
Permetrina/química
Ratos
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
509F88P9SZ (Permethrin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE


  9 / 1956 MEDLINE  
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[PMID]:28650966
[Au] Autor:Francis S; Saavedra-Rodriguez K; Perera R; Paine M; Black WC; Delgoda R
[Ad] Endereço:Natural Products Institute, Faculty of Science and Technology, University of the West Indies, Mona, Jamaica.
[Ti] Título:Insecticide resistance to permethrin and malathion and associated mechanisms in Aedes aegypti mosquitoes from St. Andrew Jamaica.
[So] Source:PLoS One;12(6):e0179673, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The emergence of novel diseases spread by the Aedes aegypti mosquito in Jamaica and the Caribbean, has prompted studies on insecticide resistance towards effective management of the vector. Though Jamaica has been using the organophosphate insecticide malathion in its vector control program for more than 30 years, resistance to the pesticide has not been tested in over a decade. We analyzed resistance to malathion and the pyrethroid insecticide, permethrin on mosquitoes collected across St. Andrew, Jamaica, and analyzed the molecular basis of resistance. The Center for Disease Control (CDC) bioassay revealed that Ae. aegypti mosquitoes from St. Andrew, Jamaica were resistant to permethrin (15 µg/bottle) with mortalities at 0-8% at 30 minute exposure time, while contact with malathion (50 µg/bottle) revealed ≤ 50% mortality at 15 minutes, which increased to 100% at 45 minutes. The standard susceptible New Orleans (NO) strain exhibited 100% mortality within15 minutes. The activities of multifunction oxidases and p-nitro phenyl-acetate esterases were significantly greater in most Jamaican populations in comparison to the NO strain, while activities of glutathione-S-transferase, acetylcholinesterase, α-esterase and ß-esterase activity were relatively equal, or lower than that of the control strain. The frequency of knockdown resistance mutations in the voltage dependent sodium channel gene were measured. All collections were fixed for Cys1,534 while 56% of mosquitoes were Ile1,016/Val1,016 heterozygotes, and 33% were Ile1,016 homozygotes. Aedes aegypti from St. Andrew Jamaica are resistant to permethrin with variations in the mode of mechanism, and possibly developing resistance to malathion. Continued monitoring of resistance is critically important to manage the spread of the vector in the country.
[Mh] Termos MeSH primário: Aedes/efeitos dos fármacos
Resistência a Inseticidas/genética
Inseticidas/farmacologia
Malation/farmacologia
Controle de Mosquitos/métodos
Permetrina/farmacologia
[Mh] Termos MeSH secundário: Animais
Jamaica
Mutação
Canais de Sódio Disparados por Voltagem/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Voltage-Gated Sodium Channels); 509F88P9SZ (Permethrin); U5N7SU872W (Malathion)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179673


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[PMID]:28639697
[Au] Autor:Eiden AL; Kaufman PE; Oi FM; Dark MJ; Bloomquist JR; Miller RJ
[Ad] Endereço:Department of Entomology and Nematology, University of Florida, Gainesville, FL, U.S.A.
[Ti] Título:Determination of metabolic resistance mechanisms in pyrethroid-resistant and fipronil-tolerant brown dog ticks.
[So] Source:Med Vet Entomol;31(3):243-251, 2017 Sep.
[Is] ISSN:1365-2915
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Rhipicephalus sanguineus (Latreille) (Ixodida: Ixodidae) is a three-host dog tick found worldwide that is able to complete its' entire lifecycle indoors. Options for the management of R. sanguineus are limited and its' control relies largely on only a few acaricidal active ingredients. Previous studies have confirmed permethrin resistance and fipronil tolerance in R. sanguineus populations, commonly conferred by metabolic detoxification or target site mutations. Herein, five strains of permethrin-resistant and three strains of fipronil-tolerant ticks were evaluated for metabolic resistance using synergists to block metabolic enzymes. Synergist studies were completed with triphenyl phosphate (TPP) for esterase inhibition, piperonyl butoxide (PBO) for cytochrome P450 inhibition, and diethyl maleate (DEM) for glutathione-S-transferase inhibition. Additionally, increased esterase activity was confirmed using gel electrophoresis. The most important metabolic detoxification mechanism in permethrin-resistant ticks was increased esterase activity, followed by increased cytochrome P450 activity. The inhibition of metabolic enzymes did not have a marked impact on fipronil-tolerant tick strains.
[Mh] Termos MeSH primário: Acaricidas/farmacologia
Resistência a Medicamentos
Permetrina/farmacologia
Pirazóis/farmacologia
Rhipicephalus sanguineus/metabolismo
[Mh] Termos MeSH secundário: Animais
Inativação Metabólica
Larva/efeitos dos fármacos
Larva/crescimento & desenvolvimento
Larva/metabolismo
Rhipicephalus sanguineus/efeitos dos fármacos
Rhipicephalus sanguineus/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Pyrazoles); 509F88P9SZ (Permethrin); QGH063955F (fipronil)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1111/mve.12240



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