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  1 / 1423 MEDLINE  
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ALVARENGA, Elson Santiago
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[PMID]:29286652
[Au] Autor:Pinheiro PF; Menini LAP; Bernardes PC; Saraiva SH; Carneiro JWM; Costa AV; Arruda TR; Lage MR; Gonçalves PM; Bernardes CO; Alvarenga ES; Menini L
[Ti] Título:Semisynthetic Phenol Derivatives Obtained from Natural Phenols: Antimicrobial Activity and Molecular Properties.
[So] Source:J Agric Food Chem;66(1):323-330, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Semisynthetic phenol derivatives were obtained from the natural phenols: thymol, carvacrol, eugenol, and guaiacol through catalytic oxychlorination, Williamson synthesis, and aromatic Claisen rearrangement. The compounds characterization was carried out by H NMR, C NMR, and mass spectrometry. The natural phenols and their semisynthetic derivatives were tested for their antimicrobial activity against the bacteria: Staphylococcus aureus, Escherichia coli, Listeria innocua, Pseudomonas aeruginosa, Salmonella enterica Typhimurium, Salmonella enterica ssp. enterica, and Bacillus cereus. Minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values were determined using concentrations from 220 to 3.44 µg mL . Most of the tested compounds presented MIC values ≤220 µg mL for all the bacteria used in the assays. The molecular properties of the compounds were computed with the PM6 method. Through principle components analysis, the natural phenols and their semisynthetic derivatives with higher antimicrobial potential were grouped.
[Mh] Termos MeSH primário: Antibacterianos/síntese química
Antibacterianos/farmacologia
Fenol/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Escherichia coli/efeitos dos fármacos
Eugenol/química
Eugenol/farmacologia
Listeria/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Monoterpenos/química
Monoterpenos/farmacologia
Fenol/síntese química
Fenol/química
Salmonella typhimurium/efeitos dos fármacos
Staphylococcus aureus/efeitos dos fármacos
Timol/química
Timol/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Monoterpenes); 339NCG44TV (Phenol); 3J50XA376E (Thymol); 3T8H1794QW (Eugenol); 9B1J4V995Q (carvacrol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04418


  2 / 1423 MEDLINE  
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[PMID]:28771007
[Au] Autor:Wang TT; Shi ZQ; Hu LB; Xu XF; Han FX; Zhou LG; Chen J
[Ad] Endereço:Institute of Food Quality and Safety, Jiangsu Academy of Agricultural Sciences , Nanjing 210014, China.
[Ti] Título:Thymol Ameliorates Cadmium-Induced Phytotoxicity in the Root of Rice (Oryza sativa) Seedling by Decreasing Endogenous Nitric Oxide Generation.
[So] Source:J Agric Food Chem;65(34):7396-7405, 2017 Aug 30.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thymol has been developed as medicine and food preservative due to its immune-regulatory effect and antimicrobial activity, respectively. However, little is currently known about the role of thymol in the modulation of plant physiology. In the present study, we applied biochemical and histochemical approaches to investigate thymol-induced tolerance in rice (Oryza sativa) seedlings against Cd (cadmium) stress. Thymol at 20 µM recovered root growth completely upon CdCl exposure. Thymol pronouncedly decreased Cd-induced ROS accumulation, oxidative injury, cell death, and Cd accumulation in roots. Pharmaceutical experiments suggested that endogenous NO mediated Cd-induced phytotoxicity. Thymol decreased Cd-induced NO accumulation by suppressing the activity of NOS (nitric oxide synthase) and NR (nitrate reductase) in root. The application of NO donor (SNP, sodium nitroprusside) resulted in the increase in endogenous NO level, which in turn compromised the alleviating effects of thymol on Cd toxicity. Such findings may helpful to illustrate the novel role of thymol in the modulation of plant physiology, which may be applicable to improve crop stress tolerance.
[Mh] Termos MeSH primário: Cádmio/toxicidade
Óxido Nítrico/metabolismo
Oryza/metabolismo
Timol/metabolismo
[Mh] Termos MeSH secundário: Cádmio/metabolismo
Óxido Nítrico Sintase/genética
Óxido Nítrico Sintase/metabolismo
Oryza/enzimologia
Oryza/genética
Oryza/crescimento & desenvolvimento
Estresse Oxidativo
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
Raízes de Plantas/metabolismo
Plântulas/enzimologia
Plântulas/genética
Plântulas/crescimento & desenvolvimento
Plântulas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Proteins); 00BH33GNGH (Cadmium); 31C4KY9ESH (Nitric Oxide); 3J50XA376E (Thymol); EC 1.14.13.39 (Nitric Oxide Synthase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b02950


  3 / 1423 MEDLINE  
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[PMID]:28556574
[Au] Autor:Aboukhalid K; Al Faiz C; Douaik A; Bakha M; Kursa K; Agacka-Moldoch M; Machon N; Tomi F; Lamiri A
[Ad] Endereço:Institut National de la Recherche Agronomique, CRRA-Rabat, PB 6570, 10101, Rabat, Morocco.
[Ti] Título:Influence of Environmental Factors on Essential Oil Variability in Origanum compactum Benth. Growing Wild in Morocco.
[So] Source:Chem Biodivers;14(9), 2017 Sep.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The present study aimed to evaluate the influence of environmental factors on essential oils (EOs) composition of Origanum compactum populations sampled all over the distribution area of the species in Morocco, and to determine the extent of the chemical profiles throughout the geographical distribution of the species. The chemical compositions were submitted to canonical correlation analysis and canonical discriminant analysis that indicated a significant relationship between oil components and some environmental factors. According to their chemical composition and edapho-climatic characteristics, two major groups of populations were differentiated. The first group was composed of samples growing in regions with humid climate, clayey, sandy, and alkaline soils. These samples showed high thymol, α-terpineol, linalool, and carvacryl methyl oxide content. The second group consisted of plants belonging to semi-arid climate, and growing at high altitudes and silty soils. These samples were characterized by high carvacrol, α-thujene, α-terpinene, and myrcene content. However, populations exposed to sub-humid climate, appeared less homogeneous and belong mainly either to the first or second group. A significant correlation between some edaphic factors (pH, K O content, soil texture) and the EOs yield of O. compactum plants was evidenced. In spite of the correlation obtained for the oil composition with edapho-climatic factors and the variance explained by the environmental data set, the observed EO diversity might be also genetically determined.
[Mh] Termos MeSH primário: Óleos Voláteis/química
Origanum/química
Origanum/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Alcenos/análise
Altitude
Clima
Cicloexenos/análise
Umidade
Monoterpenos/análise
Marrocos
Timol/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkenes); 0 (Cyclohexenes); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (alpha-thujene); 21334LVV8W (alpha-terpineol); 3J50XA376E (Thymol); 3M39CZS25B (myrcene); 4YGF4PQP49 (gamma-terpinene); 9B1J4V995Q (carvacrol); D81QY6I88E (linalool)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201700158


  4 / 1423 MEDLINE  
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[PMID]:28554612
[Au] Autor:Mastro G; Tarraf W; Verdini L; Brunetti G; Ruta C
[Ad] Endereço:Department of Agriculture and Environmental Science, University of Bari "Aldo Moro", Italy. Electronic address: giuseppe.demastro@uniba.it.
[Ti] Título:Essential oil diversity of Origanum vulgare L. populations from Southern Italy.
[So] Source:Food Chem;235:1-6, 2017 Nov 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Essential oils (EOs) belonging to 25 wild populations of Origanum vulgare L. samples, growing wild in different locations of Calabria Region (Southern Italy), were analyzed using gas chromatography-mass spectrometry. The quantitative and qualitative data showed EO concentrations ranging from 0.96 to 5.10% and 37 compounds detected, representing more than 80% of the total composition of the oils. By applying hierarchical cluster analysis on the basis of the EO constituents, two main groups and three subgroups were found, reflecting the variation in the chemical composition of EOs from wild oregano populations. The first group consisted of acyclic (linalool/linalyl acetate) chemotypes with a predominant presence of linalyl acetate; the second was characterized by chemotypes rich in cymyl-compounds, mainly carvacrol, thymol and γ-terpinene. The data obtained contribute to broaden the inventory of wild oregano populations from Calabria to plan programs for the selection of chemotypes with new and specific uses.
[Mh] Termos MeSH primário: Cromatografia Gasosa-Espectrometria de Massas/métodos
Óleos Voláteis/análise
Origanum/química
[Mh] Termos MeSH secundário: Itália
Monoterpenos
Timol
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Monoterpenes); 0 (Oils, Volatile); 3J50XA376E (Thymol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE


  5 / 1423 MEDLINE  
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[PMID]:28530570
[Au] Autor:Ruiz-Rico M; Pérez-Esteve É; Bernardos A; Sancenón F; Martínez-Máñez R; Marcos MD; Barat JM
[Ad] Endereço:Grupo de Investigación e Innovación Alimentaria, Departamento de Tecnología de Alimentos, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain. Electronic address: maruiri@etsia.upv.es.
[Ti] Título:Enhanced antimicrobial activity of essential oil components immobilized on silica particles.
[So] Source:Food Chem;233:228-236, 2017 Oct 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The antimicrobial activity of essential oils components (EOCs) is well-known. However, their high volatility and powerful aroma limit their application in the formulation of a wide range of food products. In this context, the antimicrobial activity of carvacrol, eugenol, thymol and vanillin grafted onto the surface of three silica supports with different morphologies, textural properties and chemical reactivities (fumed silica, amorphous silica and MCM-41) was evaluated herein. Materials characterization revealed a good immobilization yield and all the devices showed a micro-scale particle size. Sensory evaluation revealed that sensory perception of EOCs decreases after covalent immobilization. Moreover, immobilization greatly enhanced the antimicrobial activity of the essential oil components against Listeria innocua and Escherichia coli compared to free components. The incorporation of EOCs immobilized on silica particles into pasteurized milk inoculated with L. innocua demonstrated their effectiveness not only for in vitro conditions, but also in a real food system.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Testes de Sensibilidade Microbiana
Monoterpenos
Óleos Voláteis
Dióxido de Silício
Timol
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Monoterpenes); 0 (Oils, Volatile); 3J50XA376E (Thymol); 7631-86-9 (Silicon Dioxide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE


  6 / 1423 MEDLINE  
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[PMID]:28530556
[Au] Autor:Aytac Z; Ipek S; Durgun E; Tekinay T; Uyar T
[Ad] Endereço:Institute of Materials Science & Nanotechnology, UNAM-National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey.
[Ti] Título:Antibacterial electrospun zein nanofibrous web encapsulating thymol/cyclodextrin-inclusion complex for food packaging.
[So] Source:Food Chem;233:117-124, 2017 Oct 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Thymol (THY)/γ-Cyclodextrin(γ-CD) inclusion complex (IC) encapsulated electrospun zein nanofibrous webs (zein-THY/γ-CD-IC-NF) were fabricated as a food packaging material. The formation of THY/γ-CD-IC (1:1 and 2:1) was proved by experimental (X-ray diffraction (XRD), thermal gravimetric analysis (TGA), H NMR) and computational techniques. THY/γ-CD-IC (2:1) exhibited higher preservation rate and stability than THY/γ-CD-IC (1:1). It is worth mentioning that zein-THY/γ-CD-IC-NF (2:1) preserved much more THY as observed in TGA and stability of THY/γ-CD-IC (2:1) was higher, as shown by a modelling study. Therefore, much more THY was released from zein-THY/γ-CD-IC-NF (2:1) than zein-THY-NF and zein-THY/γ-CD-IC-NF (1:1). Similarly, antibacterial activity of zein-THY/γ-CD-IC-NF (2:1) was higher than zein-THY-NF and zein-THY/γ-CD-IC-NF (1:1). It was demonstrated that zein-THY/γ-CD-IC-NF (2:1) was most effective in inhibiting the growth of bacteria on meat samples. These webs show potential application as an antibacterial food packaging material.
[Mh] Termos MeSH primário: Nanofibras
[Mh] Termos MeSH secundário: Antibacterianos
Ciclodextrinas
Embalagem de Alimentos
Timol
Zeína
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cyclodextrins); 3J50XA376E (Thymol); 9010-66-6 (Zein)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE


  7 / 1423 MEDLINE  
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[PMID]:28490064
[Au] Autor:Li J; Chang JW; Saenger M; Deering A
[Ad] Endereço:Center for Paralysis Research, Purdue University, West Lafayette, IN 47906, USA. Electronic address: jianming@purdue.edu.
[Ti] Título:Thymol nanoemulsions formed via spontaneous emulsification: Physical and antimicrobial properties.
[So] Source:Food Chem;232:191-197, 2017 Oct 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this work, we prepared various sub-micron thymol emulsions with high hydrophilic-lipophilic balance (HLB) surfactants via spontaneous emulsification. Emulsion properties, such as size, polydispersity and charge, were assessed for each surfactant type and mass fraction. Emulsion stability was characterized by monitoring droplet size following exposure to physical (centrifugation) and thermal stressors (freeze, thaw cycling). Emulsions were subsequently screened against several challenge pathogens to evaluate antimicrobial efficacy. Based on these time-kill assays, exemplary formulations were further tested as sanitizing washes on lettuce and blueberries inoculated with food-borne bacterial biofilms. Antimicrobial data elucidate both surfactant and formulation specific antagonisms between thymol and the emulsifying agents. However, the best emulsion compositions were capable of reducing planktonic bacteria by >4 logs and biofilm bacteria by 1.5-2.5 logs in 60 s. These results are comparable to the efficacy of chlorine at ∼50-200ppm. The experimental results have implications in emulsion formulations involving thymol and other terpenoids.
[Mh] Termos MeSH primário: Anti-Infecciosos
Timol
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Anti-Infecciosos/farmacologia
Emulsões
Interações Hidrofóbicas e Hidrofílicas
Tensoativos
Timol/química
Timol/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Emulsions); 0 (Surface-Active Agents); 3J50XA376E (Thymol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE


  8 / 1423 MEDLINE  
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[PMID]:28436830
[Au] Autor:Engel JB; Heckler C; Tondo EC; Daroit DJ; da Silva Malheiros P
[Ad] Endereço:Departamento de Ciências dos Alimentos, Instituto de Ciência e Tecnologia de Alimentos, Universidade Federal do Rio Grande do Sul (ICTA-UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.
[Ti] Título:Antimicrobial activity of free and liposome-encapsulated thymol and carvacrol against Salmonella and Staphylococcus aureus adhered to stainless steel.
[So] Source:Int J Food Microbiol;252:18-23, 2017 Jul 03.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Antimicrobial activity of thymol, carvacrol and thymol/carvacrol liposomes (TCL) was evaluated against two bacterial pools, each one consisting of four strains of Staphylococcus aureus or Salmonella enterica. TCL were prepared using thin-film hydration, showing 270.20nm average diameter (polydispersity index of 0.33) and zeta potential of +39.99mV. Minimum inhibitory concentration (MIC) of thymol, carvacrol and TCL against S. aureus pool was 0.662mg/ml, while MIC for Salmonella pool was 0.331mg/ml for thymol and carvacrol, and for TCL was 0.662mg/ml. Bacterial pools (8.0logCFU/ml), allowed in contact on stainless steel AISI 304 coupons in UHT skim milk for 15min, resulted in adhered populations of 5.6-6.1logCFU/cm . Adhered S. aureus (±6.1logCFU/cm ) were inhibited after 1-min and 10-min treatments using thymol or carvacrol at MIC and 2.0 MIC. Reductions of 1.47-1.76logCFU/cm and 1.87-2.04logCFU/cm were obtained using 0.5 MIC of thymol and carvacrol, respectively. A 10-min contact with free (MIC and 2.0 MIC) and encapsulated (MIC) antimicrobials inhibited attached Salmonella (±6.0logCFU/cm ); however, after 1-min of contact, 2.0 MIC of thymol and carvacrol were not able to inactivate adhered Salmonella MIC of TCL inactivated S. aureus and Salmonella after 10min; however, after 1-min contact, adhered S. aureus and Salmonella populations were decreased in 1.62logCFU/cm and 2.01logCFU/cm , respectively. Considering antimicrobial concentrations and contact times, thymol, carvacrol, and TCL could be employed in food-contact surfaces to prevent biofilm formation at early stages of bacterial attachment. Further investigations should be performed considering long-term antibacterial effects of TCL.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Portadores de Fármacos/farmacologia
Lipossomos/farmacologia
Monoterpenos/farmacologia
Salmonella enterica/crescimento & desenvolvimento
Staphylococcus aureus/crescimento & desenvolvimento
Timol/farmacologia
[Mh] Termos MeSH secundário: Aderência Bacteriana/fisiologia
Combinação de Medicamentos
Testes de Sensibilidade Microbiana
Infecções por Salmonella/prevenção & controle
Salmonella enterica/efeitos dos fármacos
Aço Inoxidável
Infecções Estafilocócicas/prevenção & controle
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Drug Carriers); 0 (Drug Combinations); 0 (Liposomes); 0 (Monoterpenes); 12597-68-1 (Stainless Steel); 3J50XA376E (Thymol); 9B1J4V995Q (carvacrol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE


  9 / 1423 MEDLINE  
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[PMID]:28400011
[Au] Autor:Campion A; Morrissey R; Field D; Cotter PD; Hill C; Ross RP
[Ad] Endereço:School of Microbiology, University College Cork, Cork, Ireland.
[Ti] Título:Use of enhanced nisin derivatives in combination with food-grade oils or citric acid to control Cronobacter sakazakii and Escherichia coli O157:H7.
[So] Source:Food Microbiol;65:254-263, 2017 Aug.
[Is] ISSN:1095-9998
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cronobacter sakazakii and Escherichia coli O157:H7 are well known food-borne pathogens that can cause severe disease. The identification of new alternatives to heating to control these pathogens in foods, while reducing the impact on organoleptic properties and nutritional value, is highly desirable. In this study, nisin and its bioengineered variants, nisin V and nisin S29A, are used alone, or in combination with plant essential oils (thymol, carvacrol and trans-cinnamaldehyde) or citric acid, with a view to controlling C. sakazakii and E. coli O157:H7 in laboratory-based assays and model food systems. The use of nisin variants (30 µM) with low concentrations of thymol (0.015%), carvacrol (0.03%) and trans-cinnamaldehyde (0.035%) resulted in extended lag phases of growth compared to those for corresponding nisin A-essential oil combinations. Furthermore, nisin variants (60 µM) used in combination with carvacrol (0.03%) significantly reduced viable counts of E. coli O157:H7 (3-log) and C. sakazakii (4-log) compared to nisin A-carvacrol treatment. Importantly, this increased effectiveness translated into food. More specifically, sub-inhibitory concentrations of nisin variants and carvacrol caused complete inactivation of E. coli O157:H7 in apple juice within 3 h at room temperature compared to that of the equivalent nisin A combination. Furthermore, combinations of commercial Nisaplin and the food additive citric acid reduced C. sakazakii numbers markedly in infant formula within the same 3 h period. These results highlight the potential benefits of combining nisin and variants thereof with carvacrol and/or citric acid for the inhibition of Gram negative food-borne pathogens.
[Mh] Termos MeSH primário: Ácido Cítrico/farmacologia
Cronobacter sakazakii/efeitos dos fármacos
Escherichia coli O157/efeitos dos fármacos
Conservação de Alimentos/métodos
Conservantes de Alimentos/farmacologia
Nisina/análogos & derivados
Óleos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Acroleína/análogos & derivados
Acroleína/farmacologia
Antibacterianos/farmacologia
Bioengenharia
Contagem de Colônia Microbiana
Cronobacter sakazakii/crescimento & desenvolvimento
Escherichia coli O157/crescimento & desenvolvimento
Aromatizantes/farmacologia
Microbiologia de Alimentos
Sucos de Frutas e Vegetais/microbiologia
Seres Humanos
Lactente
Fórmulas Infantis/microbiologia
Malus
Monoterpenos/farmacologia
Nisina/química
Nisina/farmacologia
Timol/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Flavoring Agents); 0 (Food Preservatives); 0 (Monoterpenes); 0 (Plant Oils); 0 (nisin A); 1414-45-5 (Nisin); 2968PHW8QP (Citric Acid); 3J50XA376E (Thymol); 7864XYD3JJ (Acrolein); 9B1J4V995Q (carvacrol); SR60A3XG0F (cinnamic aldehyde)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170427
[Lr] Data última revisão:
170427
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE


  10 / 1423 MEDLINE  
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[PMID]:28397757
[Au] Autor:Dong LM; Zhang M; Xu QL; Zhang Q; Luo B; Luo QW; Liu WB; Tan JW
[Ad] Endereço:Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. donglimei1990@163.com.
[Ti] Título:Two New Thymol Derivatives from the Roots of Ageratina adenophora.
[So] Source:Molecules;22(4), 2017 Apr 08.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Two new thymol derivatives, 7,9-diisobutyryloxy-8-ethoxythymol ( ) and 7-acetoxy-8-methoxy-9-isobutyryloxythymol ( ), were isolated from fresh roots of , together with four known compounds, 7,9-di-isobutyryloxy-8-methoxythymol ( ), 9-oxoageraphorone ( ), (-)-isochaminic acid ( ) and (1α,6α)-10-hydroxycar-3-ene-2-one ( ). Their structures were established on the basis of detailed spectroscopic analysis, and they were all isolated from the roots of for the first time. All the compounds were tested for their in vitro antibacterial activity toward three Gram-positive and two Gram-negative bacterial strains. Thymol derivatives - only selectively showed slight in vitro bacteriostatic activity toward three Gram-positive bacteria. The two known carene-type monoterpenes and were found to show moderate in vitro antibacterial activity against all five tested bacterial strains, with MIC values from 15.6 to 62.5 µg/mL. In addition, compounds and were further revealed to show in vitro cytotoxicity against human tumor A549, HeLa and HepG2 cell lines, with IC values ranging from 18.36 to 41.87 µM. However, their cytotoxic activities were inferior to those of reference compound adriamycin.
[Mh] Termos MeSH primário: Ageratina/química
Extratos Vegetais/química
Raízes de Plantas/química
Timol/análogos & derivados
Timol/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/farmacologia
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Bactérias/efeitos dos fármacos
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Seres Humanos
Concentração Inibidora 50
Espectroscopia de Ressonância Magnética
Testes de Sensibilidade Microbiana
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 3J50XA376E (Thymol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE



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