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  1 / 10802 MEDLINE  
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[PMID]:28465178
[Au] Autor:Das S; Ghosh S; De AK; Bera T
[Ad] Endereço:Laboratory of Nanomedicine, Division of Pharmaceutical Biotechnology, Department of Pharmaceutical Technology, Jadavpur University, 188 Raja S.C. Mallick Road, Kolkata, 700 032, W.B., India.
[Ti] Título:Oral delivery of ursolic acid-loaded nanostructured lipid carrier coated with chitosan oligosaccharides: Development, characterization, in vitro and in vivo assessment for the therapy of leishmaniasis.
[So] Source:Int J Biol Macromol;102:996-1008, 2017 Sep.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Visceral leishmaniasis (VL) is a life-threatening disease caused by Leishmania donovani due to uncontrolled parasitisation of liver, spleen, and bone marrow. Ursolic acid (UA), a promising anti-inflammatory, anti-bacterial and anti-diabetic drug used successfully for treatment of ailments. Development of new delivery system is extremely urgent for UA with better efficacy and fewer side effects. The aim of present research work was to formulate and evaluate the potential anti-leishmanial activity of UA loaded N-octyl-chitosan surface decorated nanostructured lipid carrier system (UA-NLC) for delivery to the macrophages for VL. UA-NLC were prepared and characterized for shape, size, fourier transforms scanning electron microscopy (FESEM), transmittance electron microscopy (TEM), entrapment efficiency and in vitro drug release. The results indicate that the formulated UA-NLC had nano size range (103.7±2.8nm to 143.0±3.8nm) with high drug loading capacity (12.05±0.54%) and entrapment efficiency (88.63±2.7%). Ex vivo drug uptake by macrophage was also evaluated. The UA-NLC was more effective against AG83 wild type (12 fold), SSG-R (4 fold), PMM-R (4 fold) and GE1 field isolated (3 fold) cellular amastigotes than its free form. In vivo study showed orally effective UA-NLC could suppress the parasite burden to 98.75%.
[Mh] Termos MeSH primário: Quitosana/química
Portadores de Fármacos/química
Leishmaniose/tratamento farmacológico
Lipídeos/química
Nanoestruturas/química
Triterpenos/química
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Administração Oral
Animais
Desenho de Drogas
Liberação Controlada de Fármacos
Feminino
Macrófagos/efeitos dos fármacos
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Oligossacarídeos/química
Triterpenos/administração & dosagem
Triterpenos/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Carriers); 0 (Lipids); 0 (Oligosaccharides); 0 (Triterpenes); 9012-76-4 (Chitosan); P3M2575F3F (ursolic acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  2 / 10802 MEDLINE  
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[PMID]:29413572
[Au] Autor:Li Y; Guo S; Hua T; Wang Y; Wei D; Zhao M; Su S; Duan JA
[Ad] Endereço:Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China.
[Ti] Título:Comparative pharmacokinetics of triterpenic acids in normal and immunosuppressed rats after oral administration of Jujubae Fructus extract by UPLC-MS/MS.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1077-1078:13-21, 2018 Mar 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The fruit of Ziziphus jujuba (Jujubae Fructus) has been used as food and crude drug for thousands of years. Although several chemical and biological studies have revealed triterpenic acid as the main bioactive constituent of Jujubae Fructus responsible for immune-regulatory activity, only few pharmacokinetic studies have been conducted. To comprehend the kinetics of triterpenic acids and promote their curative application, a sensitive and efficient ultra-performance liquid chromatography coupled with mass spectrometry method (UPLC-MS/MS) was established. UPLC-MS/MS was applied for the simultaneous determination of ceanothic acid, epiceanothic acid, pomonic acid, alphitolic acid, maslinic acid, betulinic acid, and betulonic acid in normal and immunosuppressed rat plasma samples. After sample preparation, chromatographic separation was performed on an Acquity UPLC BEH C column (2.1 × 100 mm, 1.7 µm) with acetonitrile: methanol (1:1, v/v) and 0.5% ammonium acetate in water as mobile phase. The established method was validated and found to be specific, accurate, and precise for the seven triterpenic acids, and was successfully applied for the pharmacokinetic study of rat plasma samples. The results showed that the pharmacokinetic parameters (C , T , AUC , AUC and CLz/F) in the plasma samples of immunosuppressed rats were significantly different from those in normal rats, and might provide an insight for the clinical usage of triterpenic acids from Jujubae Fructus.
[Mh] Termos MeSH primário: Triterpenos/sangue
Triterpenos/farmacocinética
Ziziphus
[Mh] Termos MeSH secundário: Administração Oral
Animais
Estabilidade de Medicamentos
Medicamentos de Ervas Chinesas/administração & dosagem
Medicamentos de Ervas Chinesas/farmacocinética
Hospedeiro Imunocomprometido
Modelos Lineares
Masculino
Ratos
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Triterpenes)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


  3 / 10802 MEDLINE  
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[PMID]:29353722
[Au] Autor:Xu GB; Xiao YH; Zhang QY; Zhou M; Liao SG
[Ad] Endereço:School of Pharmacy/State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550004, Guizhou, China; National Engineering Research Center of Miao's Medicines & Engineering Research Center for the Development and Application of Ethnic Medicine and
[Ti] Título:Hepatoprotective natural triterpenoids.
[So] Source:Eur J Med Chem;145:691-716, 2018 Feb 10.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Liver diseases are one of the leading causes of death in the world. In spite of tremendous advances in modern drug research, effective and safe hepatoprotective agents are still in urgent demand. Natural products are undoubtedly valuable sources for drug leads. A number of natural triterpenoids were reported to possess pronounced hepatoprotective effects, and triterpenoids have become one of the most important classes of natural products for hepatoprotective agents. However, the significance of natural triterpenoids has been underestimated in the hepatoprotective drug discovery, with only very limited triterpenoids being covered in the reviews of hepatoprotective natural products. In this paper, ca 350 natural triterpenoids with reported hepatoprotective effects in ca 120 references between 1975 and 2016 will be reviewed, and the structure-activity relationships of certain types of natural triterpenoids, if available, will be discussed. Patents are not included.
[Mh] Termos MeSH primário: Produtos Biológicos/farmacologia
Hepatopatias/tratamento farmacológico
Fígado/efeitos dos fármacos
Substâncias Protetoras/farmacologia
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Produtos Biológicos/química
Relação Dose-Resposta a Droga
Seres Humanos
Fígado/patologia
Estrutura Molecular
Substâncias Protetoras/química
Relação Estrutura-Atividade
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biological Products); 0 (Protective Agents); 0 (Triterpenes)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE


  4 / 10802 MEDLINE  
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[PMID]:29391000
[Au] Autor:Khan MF; Nahar N; Rashid RB; Chowdhury A; Rashid MA
[Ad] Endereço:Department of Pharmacy, State University of Bangladesh, Dhaka, 1205, Bangladesh.
[Ti] Título:Computational investigations of physicochemical, pharmacokinetic, toxicological properties and molecular docking of betulinic acid, a constituent of Corypha taliera (Roxb.) with Phospholipase A2 (PLA2).
[So] Source:BMC Complement Altern Med;18(1):48, 2018 Feb 02.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Betulinic acid (BA) is a natural triterpenoid compound and exhibits a wide range of biological and medicinal properties including anti-inflammatory activity. Therefore, this theoretical investigation is performed to evaluate (a) physicochemical properties such as acid dissociation constant (pKa), distribution coefficient (logD), partition coefficient (logP), aqueous solubility (logS), solvation free energy, dipole moment, polarizability, hyperpolarizability and different reactivity descriptors, (b) pharmacokinetic properties like human intestinal absorption (HIA), cellular permeability, skin permeability (P ), plasma protein binding (PPB), penetration of the blood brain barrier (BBB), (c) toxicological properties including mutagenicity, carcinogenicity, risk of inhibition of hERG gene and (d) molecular mechanism of anti-inflammatory action which will aid the development of analytical method and the synthesis of BA derivatives. METHODS: The physicochemical properties were calculated using MarvinSketch 15.6.29 and Gaussian 09 software package. The pharmacokinetic and toxicological properties were calculated on online server PreADMET. Further, the molecular docking study was conducted on AutoDock vina in PyRx 0.8. RESULTS: The aqueous solubility increased with increasing pH due to the ionization of BA leading to decrease in distribution coefficient. The solvation energies in water, dimethyl sulfoxide (DMSO), acetonitrile, n-octanol, chloroform and carbon tetrachloride were - 41.74 kJ/mol, - 53.80 kJ/mol, - 66.27 kJ/mol, - 69.64 kJ/mol, - 65.96 kJ/mol and - 60.13 kJ/mol, respectively. From the results of polarizability and softness, it was clear that BA is less stable and hence, kinetically more reactive in water. BA demonstrated good human intestinal absorption (HIA) and moderate cellular permeability. Further, BA also exhibited positive CNS activity due to high permeability through BBB. The toxicological study revealed that BA was a mutagenic compound but noncarcinogenic in mice model. Moreover, molecular docking study of BA with PLA2 revealed that BA interacts with GLY22 & GLY29 through hydrogen bond formation and LEU2, PHE5, HIS6, ALA17, ALA18, HIS47 and TYR51 through different types of hydrophobic interactions. The binding affinity of BA was - 41.00 kJ/mol which is comparable to the binding affinity of potent inhibitor 6-Phenyl-4(R)-(7-Phenyl-heptanoylamino)-hexanoic acid (BR4) (- 33.89 kJ/mol). CONCLUSIONS: Our computed properties may assist the development of analytical method to assay BA or to develop BA derivatives with better pharmacokinetic and toxicological profile.
[Mh] Termos MeSH primário: Fosfolipases A2/química
Fosfolipases A2/metabolismo
Triterpenos/química
Triterpenos/metabolismo
[Mh] Termos MeSH secundário: Fenômenos Químicos
Concentração de Íons de Hidrogênio
Simulação de Acoplamento Molecular
Fosfolipases A2/análise
Ligação Proteica
Termodinâmica
Triterpenos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Triterpenes); 4G6A18707N (betulinic acid); EC 3.1.1.4 (Phospholipases A2)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-018-2116-x


  5 / 10802 MEDLINE  
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[PMID]:28480734
[Au] Autor:Kumar A; Chand G; Agnihotri VK
[Ad] Endereço:a Academy of Scientific and Innovative Research , CSIR-Institute of Himalayan Bioresource Technology , Palampur , India.
[Ti] Título:A new oxo-sterol derivative from the rhizomes of Costus speciosus.
[So] Source:Nat Prod Res;32(1):18-22, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chemical investigation of the rhizomes of Costus speciosus led to the isolation of a new compound, 22-ketocholesteryl palmitate (1) along with four known compounds, 24-methylenecycloartanol (2), cycloartanol (3), stigmasterol (4) and linoleic acid (5). The structure of new compound was characterised by extensive 1D-, 2D-NMR and mass spectrometry (GC-MS and HR-ESI-MS) techniques.
[Mh] Termos MeSH primário: Costus/química
Cetosteroides/química
Rizoma/química
Esteróis/química
[Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas
Ácido Linoleico/química
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Espectrometria de Massas por Ionização por Electrospray/métodos
Estigmasterol/química
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (24-methylenecycloartenol); 0 (Ketosteroids); 0 (Sterols); 0 (Triterpenes); 99WUK5D0Y8 (Stigmasterol); 9KJL21T0QJ (Linoleic Acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1324962


  6 / 10802 MEDLINE  
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[PMID]:28627258
[Au] Autor:Manjunath BN; Shenvi S; Raja A; Reddy GC
[Ad] Endereço:a Chemical Sciences Division , Vittal Mallya Scientific Research Foundation , Bangalore , India.
[Ti] Título:New water soluble glycosides of 11-keto-ß-boswellic acid: A paradigm.
[So] Source:Nat Prod Res;32(2):154-161, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Though several glycosides of various triterpenes are known, but surprisingly no boswellic acid glycosides are reported so far. With a view to make water soluble boswellic acids, prepared glycosides of 11-keto boswellic acid for the first time. Naturally occurring boswellic acids which are anti-inflammatory agents are lipophylic in nature and thus, become a limiting factor in terms of their bioavailability. Among boswellic acids, 11-keto-ß-boswellic acid is found to exhibit superior biological activity and hence successfully prepared its glucosyl and maltosyl derivatives viz., 11-keto-ß-boswellic acid-24-O-ß-D-glucopyranoside (9) and 11-keto-ß-boswellic acid-24-O-α-D-glucopyranosyl-(1 â†’ 4)-ß-D-glucopyranoside (15) which are water soluble. Both these compounds are soluble in water to the extent of 10% (w/w) which is very significant.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacocinética
Glicosídeos/farmacocinética
Triterpenos/síntese química
[Mh] Termos MeSH secundário: Anti-Inflamatórios/síntese química
Anti-Inflamatórios/química
Disponibilidade Biológica
Boswellia/química
Glicosídeos/síntese química
Glicosídeos/química
Solubilidade
Triterpenos/química
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (11-keto-boswellic acid); 0 (Anti-Inflammatory Agents); 0 (Glycosides); 0 (Triterpenes); 059QF0KO0R (Water); 631-69-6 (boswellic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1342084


  7 / 10802 MEDLINE  
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[PMID]:29316537
[Au] Autor:Bildziukevich U; Rárová L; Saman D; Wimmer Z
[Ad] Endereço:University of Chemistry and Technology, Department of Chemistry of Natural Compounds, Technická 5, 166 28 Prague 6, Czech Republic; Institute of Experimental Botany AS CR, v.v.i., Isotope Laboratory, Vídenská 1083, 142 20 Prague 4, Czech Republic.
[Ti] Título:Picolyl amides of betulinic acid as antitumor agents causing tumor cell apoptosis.
[So] Source:Eur J Med Chem;145:41-50, 2018 Feb 10.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:A series of picolyl amides of betulinic acid (3a-3c and 6a-6c) was prepared and subjected to the cytotoxicity screening tests. Structure-activity relationships studies resulted in finding differences in biological activity in dependence on o-, m- and p-substitution of the pyridine ring in the target amides, when cytotoxicity data of 3a-3c and 6a-6c were obtained and compared. The amides 3b and 3a displayed cytotoxicity (given in the IC values) in G-361 (0.5 ±â€¯0.1 µM and 2.4 ±â€¯0.0 µM, respectively), MCF7 (1.4 ±â€¯0.1 µM and 2.2 ±â€¯0.2 µM, respectively), HeLa (2.4 ±â€¯0.4 µM and 2.3 ±â€¯0.5 µM, respectively) and CEM (6.5 ±â€¯1.5 µM and 6.9 ±â€¯0.4 µM, respectively) tumor cell lines, and showed weak effect in the normal human fibroblasts (BJ). Selectivity against all tested cancer cells was determined and compared to normal cells with therapeutic index (TI) between 7 and 100 for compounds 3a and 3b. The therapeutic index (TI = 100) was calculated for human malignant melanoma cell line (G-361) versus normal human fibroblasts (BJ). The cytotoxicity of other target amides (3c and 6a-6c) revealed lower effects than 3a and 3b in the tested cancer cell lines.
[Mh] Termos MeSH primário: Amidas/farmacologia
Antineoplásicos/farmacologia
Apoptose/efeitos dos fármacos
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Amidas/síntese química
Amidas/química
Antineoplásicos/síntese química
Antineoplásicos/química
Linhagem Celular
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Estrutura Molecular
Relação Estrutura-Atividade
Triterpenos/síntese química
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amides); 0 (Antineoplastic Agents); 0 (Triterpenes); 4G6A18707N (betulinic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE


  8 / 10802 MEDLINE  
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[PMID]:28743418
[Au] Autor:Kwon M; Ji HK; Goo SH; Nam SJ; Kang YJ; Lee E; Liu KH; Choi MK; Song IS
[Ad] Endereço:Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 41566, Republic of Korea; College of Pharmacy, Kyungpook National University, Daegu, 41566, Republic of Korea.
[Ti] Título:Involvement of intestinal efflux and metabolic instability in the pharmacokinetics of platycodin D in rats.
[So] Source:Drug Metab Pharmacokinet;32(5):248-254, 2017 Oct.
[Is] ISSN:1880-0920
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We aimed to investigate the underlying mechanisms for low bioavailability of Platycodin D (PD) in rats. The bioavailability of PD was 1.89% with different half-lives depending on the administration route (2.14 ± 0.18 h for intravenous injection vs 5.42 ± 1.9 h for oral administration). The mean absorption time was 6.3 h calculated from the mean residence time of both administration routes. Consistent with these parameters, rat intestinal permeability using 3 different intestinal segments showed a low but greatest permeability in lower ileum (0.05 × 10 cm/s in jejunum and upper ileum vs 0.13 × 10 cm/s in lower ileum). The involvement of efflux system, probably Mrps, in upper ileum, could be explained from the efflux ratio of 6.4 and reduced efflux ratio by an Mrp inhibitor, MK571. The recovery of unchanged PD after the intravenous and oral administration was 50% and 5.2%, respectively, suggesting the contribution of gastrointestinal metabolism. In the gastrointestinal content, 4 metabolites of PD were identified: acetylated PD (m/z 1265.6), deglucose PD (m/z 1061.5), deapiose PD (m/z 1091.5), and deapiose-dexylose-derhamnose PD (m/z 813.4). In conclusion, the intestinal first-pass effect such as the presence of efflux functions in the upper ileum, limited but steady intestinal permeability, and gastrointestinal metabolism could explain the low bioavailability and prolonged absorption time of orally administered PD.
[Mh] Termos MeSH primário: Intestinos/metabolismo
Saponinas/farmacocinética
Triterpenos/farmacocinética
[Mh] Termos MeSH secundário: Animais
Disponibilidade Biológica
Injeções Intravenosas
Masculino
Ratos
Ratos Sprague-Dawley
Saponinas/administração & dosagem
Triterpenos/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Saponins); 0 (Triterpenes); CWJ06TA2GI (platycodin D)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


  9 / 10802 MEDLINE  
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[PMID]:29374711
[Au] Autor:Jung J; Seo J; Kim J; Kim JH
[Ad] Endereço:Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
[Ti] Título:Ursolic Acid Causes Cell Death in PC-12 Cells by Inducing Apoptosis and Impairing Autophagy.
[So] Source:Anticancer Res;38(2):847-853, 2018 02.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Ursolic acid (UA) is a natural pentacyclic triterpene that has various biological activities, including anticancer and anti-inflammatory effects. This study investigated the ability of UA to cause cell death in pheochromocytoma (PC-12) cells. UA was cytotoxic to PC-12 cells (half-maximum inhibitory concentration=53.2 µM) and significantly reduced the clonogenic ability of PC-12 cells. It also triggered apoptosis by reducing the level of B-cell lymphoma 2 (BCL2), activating caspase-3, and inducing cleavage of poly (ADP-ribosyl) polymerase. To investigate the effects of UA treatment on the induction and progression of autophagy, the levels of p62 and the conversion of the microtubule-associated protein light chain 3 (LC3)-I to LC3-II, which are important markers of autophagic flux, were monitored. UA treatment induced the accumulation of p62 and increased the LC3-II/LC3-I ratio. These results demonstrate that UA treatment induced autophagy, but the downstream signaling pathway was blocked. In summary, this study shows that UA kills PC-12 cells by inducing apoptosis and impairing autophagy progression.
[Mh] Termos MeSH primário: Neoplasias das Glândulas Suprarrenais/tratamento farmacológico
Neoplasias das Glândulas Suprarrenais/patologia
Apoptose/efeitos dos fármacos
Autofagia/efeitos dos fármacos
Feocromocitoma/tratamento farmacológico
Feocromocitoma/patologia
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/farmacologia
Apoptose/fisiologia
Autofagia/fisiologia
Proliferação Celular/efeitos dos fármacos
Células PC12
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Triterpenes); P3M2575F3F (ursolic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180129
[St] Status:MEDLINE


  10 / 10802 MEDLINE  
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Registro de Ensaios Clínicos
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[PMID]:29316908
[Au] Autor:Haroyan A; Mukuchyan V; Mkrtchyan N; Minasyan N; Gasparyan S; Sargsyan A; Narimanyan M; Hovhannisyan A
[Ad] Endereço:"Erebuni" Medical Center, 14 Titogradian Street, 0087, Yerevan, Armenia. rheumo_arm@yahoo.com.
[Ti] Título:Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study.
[So] Source:BMC Complement Altern Med;18(1):7, 2018 Jan 09.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of this clinical trial was to assess the efficacy and safety of curcuminoid complex extract from turmeric rhizome with turmeric volatile oil (CuraMed®) and its combination with boswellic acid extract from Indian frankincense root (Curamin®) vs placebo for the treatment of 40- to 70-year-old patients with osteoarthritis (OA). METHODS: The effects of CuraMed® 500-mg capsules (333 mg curcuminoids) and Curamin® 500-mg capsules (350 mg curcuminoids and 150 mg boswellic acid) taken orally three times a day for 12 weeks in 201 patients was investigated in a three-arm, parallel-group, randomized, double-blinded, placebo-controlled trial. Primary outcome efficacy measures included OA physical function performance-based tests, the WOMAC recommended index of joint pain, morning stiffness, limitations of physical function, and the patients' global assessment of disease severity. RESULTS: Favorable effects of both preparations compared to placebo were observed after only 3 months of continuous treatment. A significant effect of Curamin® compared to placebo was observed both in physical performance tests and the WOMAC joint pain index, while superior efficacy of CuraMed vs placebo was observed only in physical performance tests. The effect size compared to placebo was comparable for both treatment groups but was superior in the Curamin® group. The treatments were well tolerated. CONCLUSIONS: Twelve-week use of curcumin complex or its combination with boswellic acid reduces pain-related symptoms in patients with OA. Curcumin in combination with boswellic acid is more effective. Combining Curcuma longa and Boswellia serrata extracts in Curamin® increases the efficacy of OA treatment presumably due to synergistic effects of curcumin and boswellic acid. TRIAL REGISTRATION: This trial is registered at the database www.clinicaltrials.gov . https://clinicaltrials.gov/ct2/show/NCT02390349?term=EuroPharma&rank=1 . Study registration number: NCT02390349 .
[Mh] Termos MeSH primário: Curcumina
Osteoartrite/tratamento farmacológico
Triterpenos
[Mh] Termos MeSH secundário: Idoso
Curcumina/administração & dosagem
Curcumina/efeitos adversos
Curcumina/uso terapêutico
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Meia-Idade
Osteoartrite/fisiopatologia
Amplitude de Movimento Articular
Triterpenos/administração & dosagem
Triterpenos/efeitos adversos
Triterpenos/uso terapêutico
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE II; COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Triterpenes); 631-69-6 (boswellic acid); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2062-z



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