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[PMID]:29441916
[Au] Autor:Fan X; Wang P; Sun Y; Jiang J; Du H; Wang Z; Duan Z; Lei H; Li H
[Ti] Título:Oleanolic acid derivatives inhibit the Wnt/ß-catenin signaling pathway by promoting the phosphorylation of ß-catenin in human SMMC-7721 cells.
[So] Source:Pharmazie;71(7):398-401, 2016 Jul 07.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Oleanolic acid, isolated from privet, has shown antitumor effects in several cancers. However, the underlying molecular mechanism associated with these effects is largely unknown. In this study, we explored the effect of oleanolic acid derivatives on the Wnt/ß-catenin signaling pathway in human hepatocellular carcinoma SMMC-7721 cells. The mRNA and protein levels of related genes were determined by real-time quantitative PCR and Western blot, respectively. Treatment of SMMC-7721 cells with oleanolic acid derivatives led to the downregulation of the mRNA and protein levels of ß-catenin, c-myc, and cyclin D1. Treatment with oleanolic acid derivatives decreased the levels of ß-catenin in both the cytoplasm and the nucleus. Moreover, oleanolic acid derivatives promoted the phosphorylation of ß-catenin (Ser33/37/Thr41) in the cytoplasm. Our results suggest that oleanolic acid derivatives inhibit the Wnt/ß-catenin signaling pathway by stimulating the phosphorylation of ß-catenin (Ser33/37/Thr41) in human SMMC-7721 cells.
[Mh] Termos MeSH primário: Ácido Oleanólico/análogos & derivados
Ácido Oleanólico/farmacologia
Via de Sinalização Wnt/efeitos dos fármacos
beta Catenina/efeitos dos fármacos
beta Catenina/metabolismo
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Núcleo Celular/efeitos dos fármacos
Núcleo Celular/metabolismo
Ciclina D1/antagonistas & inibidores
Ciclina D1/biossíntese
Citoplasma/efeitos dos fármacos
Citoplasma/metabolismo
Regulação para Baixo/efeitos dos fármacos
Regulação Neoplásica da Expressão Gênica
Seres Humanos
Fosforilação/efeitos dos fármacos
Proteínas Proto-Oncogênicas c-myc/antagonistas & inibidores
Proteínas Proto-Oncogênicas c-myc/biossíntese
RNA Mensageiro/biossíntese
RNA Mensageiro/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (CTNNB1 protein, human); 0 (Proto-Oncogene Proteins c-myc); 0 (RNA, Messenger); 0 (beta Catenin); 136601-57-5 (Cyclin D1); 6SMK8R7TGJ (Oleanolic Acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6536


  2 / 2943 MEDLINE  
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[PMID]:28659043
[Au] Autor:Liu X; Zhang J; Guo K; Jia A; Zhang M; Shi Y; Liu C; Xiao L; Sun Z
[Ad] Endereço:a Key Laboratory for Biosensors of Shandong Province , Biology Institute of Shandong Academy of Sciences , Jinan , China.
[Ti] Título:Three new oleanane-type triterpenoid saponins from the seeds of Celosia cristata L.
[So] Source:Nat Prod Res;32(2):167-174, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of the 1-butanol soluble fraction of 60% ethanol extract of the seeds of Celosia cristata L. led to the identification of three new oleanane-type triterpenoid saponins. Using D and D NMR experiment methods, ESI-MS analysis and acid hydrolysis, their structures were identified as 3-O-[ß-D-xylopyranosyl-(1 â†’ 3)-ß-D-glucuronopyranosyl]-2ß-hydroxy-oleanolic acid-28-O-ß-D-glucopyranoside (1), 3-O-[ß-D-xylopyranosyl-(1 â†’ 3)-ß-D-glucuronopyranosyl]-2ß, 23-dihydroxy-oleanolic acid-28-O-ß-D-glucopyranoside (2) and 3-O-[ß-D-glucopyranosyl-(1 â†’ 4)-ß-D-glucopyranosyl]-2-hydroxyl-medicagenic acid-28-O-ß-D-glucopyranosyide (3), respectively.
[Mh] Termos MeSH primário: Celosia/química
Ácido Oleanólico/análogos & derivados
Ácido Oleanólico/isolamento & purificação
Saponinas/isolamento & purificação
[Mh] Termos MeSH secundário: Configuração de Carboidratos
Sequência de Carboidratos
Hidrólise
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Ácido Oleanólico/química
Saponinas/química
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Saponins); 0 (oleanane); 6SMK8R7TGJ (Oleanolic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1343317


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[PMID]:28458357
[Au] Autor:Wang R; Zheng QX; Wang W; Feng L; Li HJ; Huai QY
[Ad] Endereço:Marine College, Shandong University.
[Ti] Título:Design and Synthesis of New Anticancer Glycyrrhetinic Acids and Oleanolic Acids.
[So] Source:Biol Pharm Bull;40(5):703-710, 2017.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:A series of new glycyrrhetinic acids and oleanolic acids has been designed and synthesized based on the principles of combinatorial chemical synthesis. Their anticancer activities were further studied by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method with hepatocellular carcinoma (Hep-G2), breast cancer (MCF-7) cell lines and a normal hepatic cell (LO2). Cytotoxicity tests (in vitro) indicated that compound 6a showed the highest cytotoxicity with the lowest IC values of 23.34 µM on Hep-G2 cells, 12.23 µM on MCF-7 cells, and 44.47 µM on LO2, which would widen the structural diversity of these anticancer targets and confirm the perspectives of further investigations.
[Mh] Termos MeSH primário: Antineoplásicos/síntese química
Desenho de Drogas
Ácido Glicirretínico/análogos & derivados
Ácido Glicirretínico/síntese química
Ácido Oleanólico/análogos & derivados
Ácido Oleanólico/síntese química
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/química
Antineoplásicos/farmacologia
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Ensaios de Seleção de Medicamentos Antitumorais
Ácido Glicirretínico/química
Células Hep G2
Seres Humanos
Células MCF-7
Ácido Oleanólico/química
Relação Estrutura-Atividade
Sais de Tetrazólio
Tiazóis
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Tetrazolium Salts); 0 (Thiazoles); 6SMK8R7TGJ (Oleanolic Acid); EUY85H477I (thiazolyl blue); P540XA09DR (Glycyrrhetinic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1248/bpb.b17-00016


  4 / 2943 MEDLINE  
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[PMID]:28466810
[Au] Autor:Phull AR; Eo SH; Kim SJ
[Ad] Endereço:Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, Chungnam 32588, Republic of Korea.
[Ti] Título:Oleanolic acid (OA) regulates inflammation and cellular dedifferentiation of chondrocytes via MAPK signaling pathways.
[So] Source:Cell Mol Biol (Noisy-le-grand);63(3):12-17, 2017 Mar 31.
[Is] ISSN:1165-158X
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Oleanolic acid (OA) is a bioactive triterpenoid in medicinal plants. It possesses various pharmacological properties, including analgesic, anti-inflammatory, and antitumor effects. The effects of OA in chondrocytes, however, are not well characterized. Here, we used rabbit articular chondrocytes as a cellular model to investigate the effects and regulatory mechanisms of OA on dedifferentiation and pro-inflammation. OA promoted dedifferentiation of chondrocytes by inhibiting type II collagen and pro-inflammatory activity by increasing cyclooxygenase-2 (COX-2) expression. Furthermore increased phosphorylation of p38 kinases and down-regulated phosphorylation of ERK was observed. Inhibition of p38 with SB203580 in OA-treated cells rescued the expression of type II collagen and suppressed the expression of COX-2. However, ERK inhibition with PD98059 accelerated the OA-induced inflammatory responses. These results suggest that OA induces loss of type II collagen expression via the p38 pathway and induces inflammation through the p38 and ERK pathways in rabbit articular chondrocytes.
[Mh] Termos MeSH primário: Condrócitos/enzimologia
Condrócitos/patologia
Inflamação/patologia
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Ácido Oleanólico/farmacologia
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Condrócitos/efeitos dos fármacos
Condrócitos/metabolismo
Colágeno Tipo II/metabolismo
Ciclo-Oxigenase 2/metabolismo
Regulação para Baixo/efeitos dos fármacos
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Fluorescência
Modelos Biológicos
Ácido Oleanólico/química
Coelhos
Regulação para Cima/efeitos dos fármacos
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Collagen Type II); 6SMK8R7TGJ (Oleanolic Acid); EC 1.14.99.1 (Cyclooxygenase 2); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.14715/cmb/2017.63.3.3


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[PMID]:29180016
[Au] Autor:Zhan C; Ahmed S; Hu S; Dong S; Cai Q; Yang T; Wang X; Li X; Hu X
[Ad] Endereço:Laboratory of Drug Discovery and Molecular Engineering, Department of Medicinal Plants, College of Plant Science and Technology, Huazhong Agricultural University (HZAU), Wuhan 430070, China; National-Regional Joint Engineering Research Center in Hubei for Medicinal Plant Breeding and Cultivation, HZ
[Ti] Título:Cytochrome P450 CYP716A254 catalyzes the formation of oleanolic acid from ß-amyrin during oleanane-type triterpenoid saponins biosynthesis in Anemone flaccida.
[So] Source:Biochem Biophys Res Commun;495(1):1271-1277, 2018 01 01.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Anemone flaccida Fr. Shmidt (Ranunculaceae), known as 'Di Wu' in China, is a perennial herb which has long been used to treat arthritis. The rhizome of A. flaccida contains pharmacologically active components i.e. oleanane-type triterpenoid saponins. Oleanolic acid is natural triterpenoid in plants with diverse biological activities. The biosynthesis of oleanolic acid involves cyclization of 2,3-oxidosqualene to the oleanane-type triterpenoid skeleton, followed by a series of oxidation reactions catalyzed by cytochrome P450 monooxygenase (CYP450). Previously, we identified four possible cytochrome P450 genes belonging to CYP716A subfamily from the transcriptome of A. flaccida. In this study, we identified one of those genes "CYP716A254" encoding a cytochrome P450 monooxygenase from A. flaccida that catalyzes the conversion of the ß-amyrin into oleanolic acid. The heterologous expression of CYP716A254 in yeast resulted in oxidation of ß-amyrin at the C-18 position to oleanolic acid production. These results provide an important basis for further studies of oleanane-type triterpenoid saponins synthesis in A. flaccida.
[Mh] Termos MeSH primário: Sistema Enzimático do Citocromo P-450/metabolismo
Ácido Oleanólico/análogos & derivados
Ácido Oleanólico/biossíntese
Ranunculaceae/enzimologia
Saponinas/biossíntese
[Mh] Termos MeSH secundário: Catálise
Ácido Oleanólico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Saponins); 6SMK8R7TGJ (Oleanolic Acid); 9035-51-2 (Cytochrome P-450 Enzyme System); KM8353IPSO (amyrin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


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[PMID]:29203373
[Au] Autor:Preciado LM; Rey-Suárez P; Henao IC; Pereañez JA
[Ad] Endereço:Programa de Ofidismo/Escorpionismo, Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia.
[Ti] Título:Betulinic, oleanolic and ursolic acids inhibit the enzymatic and biological effects induced by a P-I snake venom metalloproteinase.
[So] Source:Chem Biol Interact;279:219-226, 2018 Jan 05.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Betulinic acid (BA), Oleanolic acid (OA) and Ursolic acid (UA), are pentacyclic triterpenoids with widespread occurrence throughout the plant kingdom, these compounds are widely recognized by their pharmacological and biological properties, such as, anti-tumoral, anti-inflammatory, anti-microbial and hepatoprotective activity. In this work we determined the inhibitory ability of these compounds on the enzymatic, hemorrhagic, myotoxic and edema-inducing activities of Batx-I, a P-I metalloproteinase isolated from Bothrops atrox venom. BA, UA and OA inhibited the proteolytic activity of Batx-I on gelatin with IC values of 115.3, 223.0 and 357.3 µM, respectively. Additionally, these compounds showed inhibition of the hemorrhagic activity of Batx-I in skin with IC 345.7, 643.5 and 1077.0 µM for BA, UA and OA in preincubation experiments. In studies with independent-injection, in which Batx-I was injected and then, at the same site, a concentration of 600 µM of each compound were administered at either 0, 5 or 10 min, BA showed a significant reduction of hemorrhage at 0 and 5 min. In addition, these compounds inhibited myotoxicity and edema-forming activity of Batx-I at 600 µM concentration. Molecular docking studies suggested that these compounds could occupy part of the substrate binding cleft of the enzyme affecting its catalytic cycle. In this manner, triterpenic acids are candidates for the development of inhibitors for the prevention of local tissue damage in snakebite envenomation.
[Mh] Termos MeSH primário: Venenos de Crotalídeos/enzimologia
Metaloproteases/metabolismo
Ácido Oleanólico/farmacologia
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Bothrops/fisiologia
Edema/induzido quimicamente
Edema/prevenção & controle
Hemorragia/induzido quimicamente
Hemorragia/prevenção & controle
Metaloproteases/genética
Camundongos
Estrutura Molecular
Doenças Musculares/induzido quimicamente
Doenças Musculares/prevenção & controle
Ácido Oleanólico/química
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Crotalid Venoms); 0 (Triterpenes); 4G6A18707N (betulinic acid); 6SMK8R7TGJ (Oleanolic Acid); EC 3.4.- (Metalloproteases); P3M2575F3F (ursolic acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180103
[Lr] Data última revisão:
180103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


  7 / 2943 MEDLINE  
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[PMID]:27775214
[Au] Autor:Yano R; Takagi K; Takada Y; Mukaiyama K; Tsukamoto C; Sayama T; Kaga A; Anai T; Sawai S; Ohyama K; Saito K; Ishimoto M
[Ad] Endereço:National Institute of Agrobiological Sciences (NIAS), 2-1-2 Kannondai, Tsukuba, Ibaraki, 305-8602, Japan.
[Ti] Título:Metabolic switching of astringent and beneficial triterpenoid saponins in soybean is achieved by a loss-of-function mutation in cytochrome P450 72A69.
[So] Source:Plant J;89(3):527-539, 2017 Feb.
[Is] ISSN:1365-313X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Triterpenoid saponins are major components of secondary metabolites in soybean seeds and are divided into two groups: group A saponins, and 2,3-dihydro-2,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP) saponins. The aglycone moiety of group A saponins consists of soyasapogenol A (SA), which is an oxidized ß-amyrin product, and the aglycone moiety of the DDMP saponins consists of soyasapogenol B (SB). Group A saponins produce a bitter and astringent aftertaste in soy products, whereas DDMP saponins have known health benefits for humans. We completed map-based cloning and characterization of the gene Sg-5, which is responsible for SA biosynthesis. The naturally occurring sg-5 mutant lacks group A saponins and has a loss-of-function mutation (L164*) in Glyma15g39090, which encodes the cytochrome P450 enzyme, CYP72A69. An enzyme assay indicated the hydroxylase activity of recombinant CYP72A69 against SB, which also suggested the production of SA. Additionally, induced Glyma15g39090 mutants (R44* or S348P) lacked group A saponins similar to the sg-5 mutant, indicating that Glyma15g39090 corresponds to Sg-5. Endogenous levels of DDMP saponins were higher in the sg-5 mutant than in the wild-type lines due to the loss of the enzyme activity that converts SB to SA. Interestingly, the genomes of palaeopolyploid soybean and the closely related common bean carry multiple Sg-5 paralogs in a genomic region syntenic to the soybean Sg-5 region. However, SA did not accumulate in common bean samples, suggesting that Sg-5 activity evolved after gene duplication event(s). Our results demonstrate that metabolic switching of undesirable saponins with beneficial saponins can be achieved in soybean by disabling Sg-5.
[Mh] Termos MeSH primário: Sistema Enzimático do Citocromo P-450/metabolismo
Proteínas de Plantas/metabolismo
Saponinas/metabolismo
Feijão de Soja/metabolismo
[Mh] Termos MeSH secundário: Sequência de Bases
Sistema Enzimático do Citocromo P-450/classificação
Sistema Enzimático do Citocromo P-450/genética
Regulação Enzimológica da Expressão Gênica
Regulação da Expressão Gênica de Plantas
Variação Genética
Oxigenases de Função Mista/genética
Oxigenases de Função Mista/metabolismo
Estrutura Molecular
Mutação
Ácido Oleanólico/análogos & derivados
Ácido Oleanólico/química
Ácido Oleanólico/metabolismo
Filogenia
Proteínas de Plantas/genética
Saponinas/química
Feijão de Soja/genética
Triterpenos/química
Triterpenos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Proteins); 0 (Saponins); 0 (Triterpenes); 43T6J3O9WL (soyasapogenol A); 6SMK8R7TGJ (Oleanolic Acid); 9035-51-2 (Cytochrome P-450 Enzyme System); EC 1.- (Mixed Function Oxygenases); KM8353IPSO (amyrin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1111/tpj.13403


  8 / 2943 MEDLINE  
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[PMID]:28958944
[Au] Autor:Gao W; Bi Y; Ding L; Zhu W; Ye M
[Ad] Endereço:Department of Neurosurgery, The First Affiliated Hospital of Suzhou University, Suzhou 215000, China.
[Ti] Título:SSa ameliorates the Glu uptaking capacity of astrocytes in epilepsy via AP-1/miR-155/GLAST.
[So] Source:Biochem Biophys Res Commun;493(3):1329-1335, 2017 Nov 25.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Neuronal glutamate (Glu) release has been reported to mediate the neuronal injury of epilepsy, while Saikosaponin a (Ssa) was shown to ameliorate the epilepsy that induced by pentylenetetrazol (PTZ). However, potential interactions between glutamate release and Ssa has not been fully identified. METHODS: Herein, PTZ-induced rat model were established to evaluate the neuron injury, while Ssa was used to treat the model rat. Rat astrocytes were isolated and induced by PTZ to construct cell models of epilepsy, real-time PCR and western blot were used to determine genes' expression. Luciferase reporter assay were performed to validate the relationship between miR-155-5p and glutamate aspartate transporter (GLAST). The level of Glu was sampled for HPLC measurement. RESULTS: Ssa treatment could decrease the level of Glu in hippocampus of rat. PTZ-induced astrocytes pretreated with Ssa significantly decreased the expression of AP-1 and miR-155, but increased the expression of GLAST, furthermore, PTZ stimulation enables astrocytes to uptake large amount of extracellular Glu. AP-1 could bind with the promoter of miR-155 to promote its transcription. MiR-155 tragets GLAST to govern its expression. CONCLUSION: Ssa treatment played pivotal roles in PTZ-induced epilepsy by promoting the expression of GLAT1 and uptaking of Glu, which was mediated by the expression of AP-1 and miR-155.
[Mh] Termos MeSH primário: Astrócitos/efeitos dos fármacos
Epilepsia/tratamento farmacológico
Transportador 1 de Aminoácido Excitatório/metabolismo
Ácido Glutâmico/metabolismo
Ácido Oleanólico/análogos & derivados
Saponinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Astrócitos/metabolismo
Modelos Animais de Doenças
Epilepsia/induzido quimicamente
Epilepsia/metabolismo
Hipocampo/efeitos dos fármacos
Hipocampo/metabolismo
MicroRNAs/metabolismo
Ácido Oleanólico/farmacologia
Pentilenotetrazol/toxicidade
Proteínas Proto-Oncogênicas c-fos/metabolismo
Ratos Wistar
Fator de Transcrição AP-1/metabolismo
Ácido gama-Aminobutírico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Excitatory Amino Acid Transporter 1); 0 (Fosb protein, rat); 0 (MIRN155 microRNA, rat); 0 (MicroRNAs); 0 (Proto-Oncogene Proteins c-fos); 0 (Saponins); 0 (Slc1a3 protein, rat); 0 (Transcription Factor AP-1); 3KX376GY7L (Glutamic Acid); 56-12-2 (gamma-Aminobutyric Acid); 6SMK8R7TGJ (Oleanolic Acid); UR635J3F00 (saikosaponin); WM5Z385K7T (Pentylenetetrazole)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170930
[St] Status:MEDLINE


  9 / 2943 MEDLINE  
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[PMID]:28771341
[Au] Autor:Lee HJ; Lim SM; Ko DB; Jeong JJ; Hwang YH; Kim DH
[Ad] Endereço:Department of Life and Nanopharmaceutical Sciences, Kyung Hee University , 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
[Ti] Título:Soyasapogenol B and Genistein Attenuate Lipopolysaccharide-Induced Memory Impairment in Mice by the Modulation of NF-κB-Mediated BDNF Expression.
[So] Source:J Agric Food Chem;65(32):6877-6885, 2017 Aug 16.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lactobacillus plantarum C29-fermented defatted soybean (FDS), which contains soyasaponins such as soyasaponin I (SI) and soyasapogenol B (SB) and isoflavones such as genistin (GE) and genistein (GT), attenuated memory impairment in mice. Moreover, in the preliminary study, FDS and its soyasaponins and isoflavones significantly inhibited NF-κB activation in LPS-stimulated microglial BV2 cells. Therefore, we examined the effects of FDS and its constituents SI, SB, GT, and GE on LPS-induced memory impairment in mice. Oral administration of FDS (80 mg/kg), which has higher concentrations of SB and GE than DS, recovered LPS-impaired cognitive function in Y-maze (55.1 ± 3.5%) and passive avoidance tasks (50.9 ± 19.2 s) to 129.2% (74.1 ± 3.5%) and 114.2% (290.0 ± 22.4 s) of normal mice, respectively (P < 0.05). SB and GE (10 µM) also more potently attenuated LPS-impaired cognitive behavior than SI and GT, respectively. SB (10 mg/kg) was the most effective: treatment recovered LPS-impaired spontaneous alternation and latency time to 105.7% and 126.8% of normal control mice, respectively (P < 0.05). SB and GE significantly increased BDNF expression and CREB phosphorylation in LPS-treated mice and corticosterone-stimulated SH-SY5Y cells. Furthermore, SB and GE (10 µM) also significantly inhibited NF-κB activation in LPS-treated mice. These findings suggested that FDS and its constituent soyasaponins and isoflavones may attenuate memory impairment by the regulation of NF-κB-mediated BDNF expression.
[Mh] Termos MeSH primário: Fator Neurotrófico Derivado do Encéfalo/genética
Genisteína/administração & dosagem
Transtornos da Memória/tratamento farmacológico
Transtornos da Memória/genética
NF-kappa B/genética
Ácido Oleanólico/análogos & derivados
Extratos Vegetais/administração & dosagem
Saponinas/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Fator Neurotrófico Derivado do Encéfalo/metabolismo
Fermentação
Genisteína/metabolismo
Seres Humanos
Lipopolissacarídeos/efeitos adversos
Masculino
Transtornos da Memória/metabolismo
Camundongos
Camundongos Endogâmicos ICR
NF-kappa B/metabolismo
Ácido Oleanólico/administração & dosagem
Ácido Oleanólico/metabolismo
Extratos Vegetais/metabolismo
Saponinas/metabolismo
Feijão de Soja/metabolismo
Feijão de Soja/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Brain-Derived Neurotrophic Factor); 0 (Lipopolysaccharides); 0 (NF-kappa B); 0 (Plant Extracts); 0 (Saponins); 1EZ10D7E2F (soyasapogenol B); 6SMK8R7TGJ (Oleanolic Acid); DH2M523P0H (Genistein)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b02569


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[PMID]:28766764
[Au] Autor:Tung NH; Nakajima K; Uto T; Hai NT; Long DD; Ohta T; Oiso S; Kariyazono H; Shoyama Y
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch, Sasebo, Nagasaki, 859-3298, Japan.
[Ti] Título:Bioactive Triterpenes from the Root of Salvia miltiorrhiza Bunge.
[So] Source:Phytother Res;31(9):1457-1460, 2017 Sep.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Danshen (Salvia miltiorrhiza) is a well-known medicinal herb in the oriental medicine. The current study on bioactive triterpenoid in the root of S. miltiorrhiza led to the isolation of a new highly hydroxylated ursane-type triterpene, urs-12-ene-2α,3ß,7ß,16α-tetraol (1) and five known ones including 2ß-hydroxypomolic acid (2), maslinic acid (3), asiatic acid (4), ursolic acid (5), and oleanolic acid (6). Their structures were elucidated on the basis of extensive spectroscopic analyses and comparison with literature data. The antiproliferative testing against HL-60 cells revealed that the new compound 1 and ursolic acid (5) showed weak and moderate activities with IC values of 42.2 and 11.7 µM. In addition, compounds 1-3 showed inhibitory effect on ghrelin activity. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/química
Raízes de Plantas/química
Salvia miltiorrhiza/química
Triterpenos/química
[Mh] Termos MeSH secundário: Grelina/antagonistas & inibidores
Células HL-60
Seres Humanos
Estrutura Molecular
Ácido Oleanólico/química
Ácido Oleanólico/isolamento & purificação
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Ghrelin); 0 (Triterpenes); 0 (urs-12-ene-2alpha,3beta,7beta,16alpha-tetraol); 6SMK8R7TGJ (Oleanolic Acid); 79483-68-4 (dan-shen root extract); E233J88OHQ (maslinic acid); P3M2575F3F (ursolic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5877



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