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Pesquisa : D02.455.849.919.570.500 [Categoria DeCS]
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  1 / 113 MEDLINE  
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[PMID]:25409929
[Au] Autor:Huynh N; Beutler JA; Shulkes A; Baldwin GS; He H
[Ad] Endereço:Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria 3084, Australia.
[Ti] Título:Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1α and ß-catenin via a p-21 activated kinase 1-dependent pathway.
[So] Source:Biochim Biophys Acta;1853(1):157-65, 2015 Jan.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:p-21-Activated kinase 1 (PAK1) enhances colorectal cancer (CRC) progression by stimulating Wnt/ß-catenin, ERK and AKT pathways. PAK1 also promotes CRC survival via up-regulation of hypoxia-inducible factor 1α (HIF-1α), a key player in cancer survival. Glaucarubinone, a quassinoid natural product, inhibits pancreatic cancer growth by down-regulation of PAK1. The aim of this study was to investigate the effect of glaucarubinone on CRC growth and metastasis, and the mechanism involved. Cell proliferation was measured in vitro by [(3)H]-thymidine incorporation and in vivo by volume of tumor xenografts. Protein concentrations were measured by Western blotting of cell extracts. We report here that glaucarubinone inhibited CRC growth both in vitro and in vivo. The potency of glaucarubinone as an inhibitor of cell proliferation was negatively correlated to PAK1 expression in CRC cells. Glaucarubinone suppressed the expression of HIF-1α and ß-catenin. Knockdown of PAK1 by shRNA enhanced inhibition by glaucarubinone while constitutively active PAK1 blocked the inhibitory effect. Our findings indicate that glaucarubinone inhibited CRC growth by down-regulation of HIF-1α and ß-catenin via a PAK1-dependent pathway.
[Mh] Termos MeSH primário: Neoplasias Colorretais/tratamento farmacológico
Glaucarubina/análogos & derivados
Subunidade alfa do Fator 1 Induzível por Hipóxia/antagonistas & inibidores
beta Catenina/antagonistas & inibidores
Quinases Ativadas por p21/fisiologia
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Neoplasias Colorretais/patologia
Glaucarubina/farmacologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hypoxia-Inducible Factor 1, alpha Subunit); 0 (beta Catenin); 1259-86-5 (glaucarubinone); EC 2.7.11.1 (PAK1 protein, human); EC 2.7.11.1 (p21-Activated Kinases); EH6H7VS52J (Glaucarubin)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141121
[St] Status:MEDLINE


  2 / 113 MEDLINE  
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[PMID]:24491405
[Au] Autor:Yeo D; Huynh N; Beutler JA; Christophi C; Shulkes A; Baldwin GS; Nikfarjam M; He H
[Ad] Endereço:Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria 3084, Australia.
[Ti] Título:Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases.
[So] Source:Cancer Lett;346(2):264-72, 2014 May 01.
[Is] ISSN:1872-7980
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Pancreatic cancer is one of the most lethal of human malignancies. Nearly 100% cases of pancreatic cancer carry mutations in KRas. P-21-activated kinases (PAKs) are activated by and act downstream of KRas. Glaucarubinone, a natural product first isolated from the seeds of the tree Simarouba glauca, was originally developed as an antimalarial drug, and has more recently been recognised as an anticancer agent. The aims of this study were to determine whether glaucarubinone, alone or in combination with the front-line chemotherapeutic agent gemcitabine, would inhibit the growth of pancreatic cancer cells in vitro or in vivo and the mechanism involved. Growth of the human pancreatic cancer cell lines PANC-1 and MiaPaCa-2 was measured by (3)H-thymidine incorporation in vitro, and by volume as xenografts in SCID mice. The expression and activities of the two serine/threonine kinases PAK1 and PAK4, which are key regulators of cancer progression, were measured by Western blotting. Here we report that glaucarubinone decreased proliferation and migration of pancreatic cancer cells in vitro, and reduced their growth as xenografts in vivo. Treatment with glaucarubinone and gemcitabine reduced proliferation in vitro and tumor growth in vivo more than treatment with either glaucarubinone or gemcitabine alone. Treatment with glaucarubinone reduced PAK1 and PAK4 activities, which were further decreased by the combination of glaucarubinone and gemcitabine. These results indicate that glaucarubinone reduced pancreatic cancer cell growth at least in part via inhibition of pathways involving PAK1 and PAK4. The synergistic inhibition by glaucarubinone and gemcitabine observed both in vitro and in vivo suggests that glaucarubinone may be a useful adjunct to current regimes of chemotherapy.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia
Inibidor de Quinase Dependente de Ciclina p21/metabolismo
Desoxicitidina/análogos & derivados
Glaucarubina/análogos & derivados
Neoplasias Pancreáticas/tratamento farmacológico
Quinases Ativadas por p21/metabolismo
[Mh] Termos MeSH secundário: Animais
Processos de Crescimento Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Movimento Celular/efeitos dos fármacos
Desoxicitidina/administração & dosagem
Desoxicitidina/farmacologia
Regulação para Baixo/efeitos dos fármacos
Sinergismo Farmacológico
Ativação Enzimática
Glaucarubina/administração & dosagem
Glaucarubina/farmacologia
Seres Humanos
Camundongos
Camundongos Nus
Neoplasias Pancreáticas/enzimologia
Neoplasias Pancreáticas/metabolismo
Neoplasias Pancreáticas/patologia
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cyclin-Dependent Kinase Inhibitor p21); 0W860991D6 (Deoxycytidine); 1259-86-5 (glaucarubinone); B76N6SBZ8R (gemcitabine); EC 2.7.11.1 (p21-Activated Kinases); EH6H7VS52J (Glaucarubin)
[Em] Mês de entrada:1405
[Cu] Atualização por classe:150813
[Lr] Data última revisão:
150813
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140205
[St] Status:MEDLINE


  3 / 113 MEDLINE  
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[PMID]:21264793
[Au] Autor:Zarse K; Bossecker A; Müller-Kuhrt L; Siems K; Hernandez MA; Berendsohn WG; Birringer M; Ristow M
[Ad] Endereço:Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany.
[Ti] Título:The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat, and extends lifespan of Caenorhabditis elegans.
[So] Source:Horm Metab Res;43(4):241-3, 2011 Apr.
[Is] ISSN:1439-4286
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Naturally occurring compounds that promote energy expenditure and delay aging in model organisms may be of significant interest, since these substances potentially provide pharmaceutical approaches to tackle obesity and promote healthy lifespan in humans. We aimed to test whether pharmaceutical concentrations of glaucarubinone, a cytotoxic and antimalarial quassinoid known from different species of the plant family Simaroubaceae, are capable of affecting metabolism and/or extending lifespan in a nematodal model organism for aging processes, the roundworm Caenorhabditis elegans. Adult C. elegans roundworms, maintained on agar plates, were fed with E. coli strain OP50 bacteria, and glaucarubinone was applied to the agar to test (i) whether it alters respiration rates and mitochondrial activity, (ii) whether it affects body fat content, and (iii) whether it may promote longevity by quantifying survival in the presence and absence of the compound. We have found that glaucarubinone induces oxygen consumption and reduces body fat content of C. elegans. Moreover and consistent with the concept of mitohormesis, glaucarubinone extends C. elegans lifespan when applied at a concentration of 1 or 10 nanomolar. Taken together, glaucarubinone is capable of reducing body fat and promoting longevity in C. elegans, tentatively suggesting that this compound may promote metabolic health and lifespan in mammals and possibly humans.
[Mh] Termos MeSH primário: Tecido Adiposo/efeitos dos fármacos
Caenorhabditis elegans/efeitos dos fármacos
Glaucarubina/análogos & derivados
Longevidade/efeitos dos fármacos
Mitocôndrias/metabolismo
Extratos Vegetais/farmacologia
Simaroubaceae/química
[Mh] Termos MeSH secundário: Tecido Adiposo/metabolismo
Animais
Caenorhabditis elegans/crescimento & desenvolvimento
Caenorhabditis elegans/metabolismo
Glaucarubina/farmacologia
Seres Humanos
Modelos Animais
Consumo de Oxigênio/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts); 1259-86-5 (glaucarubinone); EH6H7VS52J (Glaucarubin)
[Em] Mês de entrada:1107
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110126
[St] Status:MEDLINE
[do] DOI:10.1055/s-0030-1270524


  4 / 113 MEDLINE  
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[PMID]:19501276
[Au] Autor:de Mesquita ML; de Paula JE; Pessoa C; de Moraes MO; Costa-Lotufo LV; Grougnet R; Michel S; Tillequin F; Espindola LS
[Ad] Endereço:Laboratório de Farmacognosia, Universidade de Brasília, Brasília, Brazil.
[Ti] Título:Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines.
[So] Source:J Ethnopharmacol;123(3):439-45, 2009 Jun 25.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: The search for new anti-cancer drugs is one of the most prominent research areas of natural products. Numerous active compounds isolated from Brazilian Cerrado plant species have been studied with promising results. AIM OF THE STUDY: To investigate the cytotoxic potential of 412 extracts from Brazilian Cerrado plants used in traditional medicine belonging to 21 families against tumor cell lines in culture. MATERIAL AND METHOD: Maceration of 50 plant species resulted in 412 hexane, dichloromethane, ethanol and hydroalcohol extracts. The cytotoxicity of the extracts was tested against human colon carcinoma (HCT-8), melanoma (MDA-MB-435), and brain (SF-295) tumor cell lines, using the thiazolyl blue test (MTT) assay. Bioassay-guided fractionation was performed for one active extract. RESULTS AND CONCLUSIONS: Twenty-eight of the 412 tested extracts demonstrated a substantial antiproliferative effect, at least 85% inhibition of cell proliferation at 50 microg/mL against one or more cell lines. Those extracts are obtained from different parts of Anacardiaceae, Annonaceae, Apocynaceae, Clusiaceae, Flacourtiaceae, Sapindaceae, Sapotaceae, Simaroubaceae and Zingiberaceae. Complete dose-response curves were generated and IC(50) values were calculated for these active extracts against four cell lines HCT-8, MDA-MB-435, SF-295 and HL-60 (leukemia), and their direct cytotoxic effects were determined. In summary, 14 extracts of 13 species showed toxicity in all tested tumor cell lines, with IC(50) values ranging from 0.1 to 19.1 microg/mL. The strongest cytotoxic activity was found for the hexane extract of Casearia sylvestris var. lingua stem bark, with an IC(50) of 0.1 microg/mL for HCT-8, 0.9 microg/mL for SF-295, 1.2 microg/mL for MDA-MB-435, and 1.3 microg/mL for HL-60, and Simarouba versicolor root bark, with an IC(50) of 0.5 microg/mL for HCT-8, 0.7 microg/mL for SF-295, 1.5 microg/mL for MDA-MB-435, 1.1 microg/mL for HL-60. Bioassay-guided fractionation of the last extract led to the isolation of glaucarubinone, which showed pronounced activity against the four cell lines studied. Further studies of the active extracts are necessary for chemical characterization of the active compounds and more extensive biological evaluations.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/uso terapêutico
Magnoliopsida/química
Medicina Tradicional
Neoplasias/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/farmacologia
Brasil
Casearia
Linhagem Celular Tumoral
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Ecossistema
Glaucarubina/análogos & derivados
Glaucarubina/isolamento & purificação
Glaucarubina/farmacologia
Glaucarubina/uso terapêutico
Seres Humanos
Concentração Inibidora 50
Extratos Vegetais/farmacologia
Estruturas Vegetais
Simarouba
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 1259-86-5 (glaucarubinone); EH6H7VS52J (Glaucarubin)
[Em] Mês de entrada:0910
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090609
[St] Status:MEDLINE
[do] DOI:10.1016/j.jep.2009.03.018


  5 / 113 MEDLINE  
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[PMID]:19199792
[Au] Autor:Beutler JA; Kang MI; Robert F; Clement JA; Pelletier J; Colburn NH; McKee TC; Goncharova E; McMahon JB; Henrich CJ
[Ad] Endereço:Molecular Targets Development Program and Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA. beutlerj@mail.nih.gov
[Ti] Título:Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition.
[So] Source:J Nat Prod;72(3):503-6, 2009 Mar 27.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Several quassinoids were identified in a high-throughput screening assay as inhibitors of the transcription factor AP-1. Further biological characterization revealed that while their effect was not specific to AP-1, protein synthesis inhibition and cell growth assays were inconsistent with a mechanism of simple protein synthesis inhibition. Numerous plant extracts from the plant family Simaroubaceae were also identified in the same screen; bioassay-guided fractionation of one extract (Ailanthus triphylla) yielded two known quassinoids, ailanthinone (3) and glaucarubinone (4), which were also identified in the pure compound screening procedure.
[Mh] Termos MeSH primário: Ailanthus/química
Citotoxinas/isolamento & purificação
Citotoxinas/farmacologia
Inibidores da Síntese de Proteínas/isolamento & purificação
Inibidores da Síntese de Proteínas/farmacologia
Quassinas/isolamento & purificação
Quassinas/farmacologia
Fator de Transcrição AP-1/antagonistas & inibidores
[Mh] Termos MeSH secundário: Citotoxinas/química
Glaucarubina/análogos & derivados
Seres Humanos
Estrutura Molecular
Inibidores da Síntese de Proteínas/química
Quassinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, N.I.H., INTRAMURAL
[Nm] Nome de substância:
0 (Cytotoxins); 0 (Protein Synthesis Inhibitors); 0 (Quassins); 0 (Transcription Factor AP-1); 0 (ailanthinone); 1259-86-5 (glaucarubinone); EH6H7VS52J (Glaucarubin)
[Em] Mês de entrada:1004
[Cu] Atualização por classe:161203
[Lr] Data última revisão:
161203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090210
[St] Status:MEDLINE
[do] DOI:10.1021/np800732n


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[PMID]:11842321
[Au] Autor:Apers S; Cimanga K; Vanden Berghe D; Van Meenen E; Longanga AO; Foriers A; Vlietinck A; Pieters L
[Ad] Endereço:Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium. Sandra.Apers@ua.ac.be
[Ti] Título:Antiviral activity of simalikalactone D, a quassinoid from Quassia africana.
[So] Source:Planta Med;68(1):20-4, 2002 Jan.
[Is] ISSN:0032-0943
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:After removing lipophilic material, the ground root bark of Quassia africana Baill. (Simaroubaceae) was extracted with ethanol 95 %. Partitioning between chloroform, ethyl acetate and water yielded three crude extracts. Pronounced activities were shown by the chloroform and ethyl acetate crude extracts against Herpes simplex, Semliki forest, Coxsackie and Vesicular stomatitis viruses. By repeated column chromatography and preparative thin layer chromatography on silica gel, two quassinoids, i. e., quassin and simalikalactone D were isolated. Structures of the pure compounds were established primarily using NMR spectroscopy. Mass spectral information confirmed the assigned structures. Simalikalactone D was responsible, at least in part, for the high antiviral activity observed for the chloroform crude extract. Quassin showed no activity. For quassinoids the ester group at C-15 and the epoxymethano bridge between C-8 and C-13 appeared to be important structural features in order to exhibit a pronounced antiviral activity.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Antivirais/farmacologia
Glaucarubina/análogos & derivados
Glaucarubina/farmacologia
Quassinas
Simaroubaceae
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Antivirais/química
Antivirais/isolamento & purificação
Glaucarubina/química
Glaucarubina/isolamento & purificação
Herpesvirus Humano 1/efeitos dos fármacos
Espectroscopia de Ressonância Magnética
Medicina Tradicional Africana
Estrutura Molecular
Casca de Planta/química
Extratos Vegetais/farmacologia
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Antiviral Agents); 0 (Plant Extracts); 0 (Quassins); 35321-80-3 (simalikalactone D); EH6H7VS52J (Glaucarubin)
[Em] Mês de entrada:0205
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:020214
[St] Status:MEDLINE


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[PMID]:11754601
[Au] Autor:Mata-Greenwood E; Daeuble JF; Grieco PA; Dou J; McChesney JD; Mehta RG; Kinghorn AD; Pezzuto JM
[Ad] Endereço:Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
[Ti] Título:Novel esters of glaucarubolone as inducers of terminal differentiation of promyelocytic HL-60 cells and inhibitors of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesion formation in mouse mammary organ culture.
[So] Source:J Nat Prod;64(12):1509-13, 2001 Dec.
[Is] ISSN:0163-3864
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In an effort to discover new chemotherapeutic/chemopreventive agents from natural sources, brusatol (1) was found to induce HL-60 cellular differentiation, accompanied by strong antiproliferative and cytotoxic effects. A series of natural and semisynthetic quassinoids (1-48) was designed to effect both antiproliferative and differentiation-inducing properties. Compounds were assessed in vitro using the HL-60 promyelocytic cell model. Changes in activity due to structural modification of the core structure glaucarubolone (24) were consistent with activities reported in other cell systems. However, the following were novel SAR findings: (1) semisynthetic analogues with a hydroxylated ring at the beta-position of the ester side chain at C-15 were able to induce cellular differentiation at concentrations lower than those inducing cell growth arrest, and (2) quassinoids inhibiting DNA synthesis with greater efficacy than reducing cellular viability possessed alkyl substitutions at the alpha-position of the C-15 ester side chain. Analogues from this latter group and brusatol (1) and bruceantin (2) inhibited dimethylbenz(a)anthracene-induced preneoplastic lesion formation in a mouse mammary organ culture. The novel finding of 1 and glaucarubolone analogues as potent inducers of differentiation leads to potential novel applications in the field of cancer.
[Mh] Termos MeSH primário: 9,10-Dimetil-1,2-benzantraceno/antagonistas & inibidores
Anticarcinógenos/farmacologia
Antineoplásicos Fitogênicos/síntese química
Diferenciação Celular/efeitos dos fármacos
Glaucarubina/análogos & derivados
Glaucarubina/síntese química
Neoplasias Mamárias Animais/induzido quimicamente
Plantas Medicinais/química
Quassinas
Simaroubaceae/química
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Divisão Celular/efeitos dos fármacos
Membrana Celular/efeitos dos fármacos
DNA/efeitos dos fármacos
DNA/metabolismo
Ensaios de Seleção de Medicamentos Antitumorais
Feminino
Glaucarubina/química
Glaucarubina/farmacologia
Glicosilação
Células HL-60/efeitos dos fármacos
Seres Humanos
Concentração Inibidora 50
Camundongos
Camundongos Endogâmicos BALB C
Modelos Biológicos
Estrutura Molecular
Nitroazul de Tetrazólio/farmacologia
Técnicas de Cultura de Órgãos
Ratos
Relação Estrutura-Atividade
Fatores de Tempo
Células Tumorais Cultivadas/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Anticarcinogenic Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Quassins); 0 (dehydrobrusatol); 0 (yadanziolide C); 14907-98-3 (brusatol); 1990-01-8 (glaucarubolone); 298-83-9 (Nitroblue Tetrazolium); 57-97-6 (9,10-Dimethyl-1,2-benzanthracene); 63306-30-9 (bruceoside A); 9007-49-2 (DNA); EH6H7VS52J (Glaucarubin); S3NW88DI4T (bruceantin)
[Em] Mês de entrada:0202
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:020105
[St] Status:MEDLINE


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[PMID]:11564133
[Au] Autor:Ang HH; Ngai TH
[Ad] Endereço:School of Pharmaceutical Sciences, University of Science Malaysia, Minden, 11800, Penang, Malaysia.
[Ti] Título:Aphrodisiac evaluation in non-copulator male rats after chronic administration of Eurycoma longifolia Jack.
[So] Source:Fundam Clin Pharmacol;15(4):265-8, 2001 Aug.
[Is] ISSN:0767-3981
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aphrodisiac effect of Eurycoma longifolia Jack (0.5 g/kg) was evaluated in noncopulator male rats using an electrical cage. Fractions of E. longifolia Jack decreased the hesitation time of noncopulator male rats, throughout the investigation period. Furthermore, it possessed a transient increase in the percentage of the male rats responding to the right choice, more than 50% of the male rats scored "right choice" after 3 weeks post-treatment and the effect became more prominent after 8 weeks post-treatment (only 40-50% of the control male rats responded to the right choice) using the electrical copulation cage. Hence, this study lends further support to the use of the plant by indigenous populations as a traditional medicine for its aphrodisiac property.
[Mh] Termos MeSH primário: Afrodisíacos/farmacologia
Copulação/efeitos dos fármacos
Glaucarubina/análogos & derivados
Glaucarubina/farmacologia
Quassinas
[Mh] Termos MeSH secundário: Animais
Copulação/fisiologia
Avaliação Pré-Clínica de Medicamentos/métodos
Feminino
Masculino
Preparações de Plantas/farmacologia
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aphrodisiacs); 0 (Plant Preparations); 0 (Quassins); 84633-28-3 (eurycomanol); EH6H7VS52J (Glaucarubin)
[Em] Mês de entrada:0112
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:010921
[St] Status:MEDLINE


  9 / 113 MEDLINE  
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[PMID]:11429258
[Au] Autor:Govindachari TR; Krishna Kumari GN; Gopalakrishnan G; Suresh G; Wesley SD; Sreelatha T
[Ad] Endereço:Centre for Natural Products, SPIC Science Foundation, 111, Mount Road, Madras 600 032, India. tuticoringovinda@hotmail.com
[Ti] Título:Insect antifeedant and growth regulating activities of quassinoids from Samadera indica.
[So] Source:Fitoterapia;72(5):568-71, 2001 Jun.
[Is] ISSN:0367-326X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Four quassinoids, indaquassin C (1), samaderins C (2), B (3) and A (4), isolated from the seeds and bark of Samadera indica, were tested for insect antifeedant and growth regulatory activities against the tobacco cutworm, Spodoptera litura. Indaquassin C was the most effective antifeedant. Samaderin C increased pupal duration and induced pupal mortality.
[Mh] Termos MeSH primário: Comportamento Alimentar/efeitos dos fármacos
Glaucarubina/farmacologia
Inseticidas/farmacologia
Quassinas
Rosales
Spodoptera/efeitos dos fármacos
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Glaucarubina/análogos & derivados
Glaucarubina/química
Inseticidas/química
Larva/efeitos dos fármacos
Caules de Planta
Sementes
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Quassins); 0 (Triterpenes); 0 (indaquassin C); 0 (samaderin A); 0 (samaderin B); 0 (samaderin C); EH6H7VS52J (Glaucarubin)
[Em] Mês de entrada:0108
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:010629
[St] Status:MEDLINE


  10 / 113 MEDLINE  
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[PMID]:11031029
[Au] Autor:Shing TK; Jiang Q
[Ad] Endereço:Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong. tonyshing@cuhk.edu.hk
[Ti] Título:Total synthesis of (+)-quassin.
[So] Source:J Org Chem;65(21):7059-69, 2000 Oct 20.
[Is] ISSN:0022-3263
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A total synthesis of (+)-quassin from naturally occurring (S)-(+)-carvone is described. The total number of steps was 28, and the overall yield was about 2.6%. The synthetic strategy for the construction of the tetracyclic carbon framework was based on a C-->ABC-->ABCD ring annulation sequence, involving an aldol reaction, an intramolecular Diels-Alder reaction, and an intramolecular acylation as the key steps. Subsequent functionalization of ring A and ring C then afforded the target (+)-quassin.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/síntese química
Glaucarubina/análogos & derivados
Quassinas
[Mh] Termos MeSH secundário: Glaucarubina/síntese química
Indicadores e Reagentes
Espectroscopia de Ressonância Magnética
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Indicators and Reagents); 0 (Quassins); EH6H7VS52J (Glaucarubin); QP1YAK6QGK (quassin)
[Em] Mês de entrada:0012
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:001014
[St] Status:MEDLINE



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