Base de dados : MEDLINE
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  1 / 12793 MEDLINE  
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[PMID]:28741868
[Au] Autor:Tanaka T; Ueno M; Nakashima Y; Chinen S; Sato E; Masaki M; Mogi A; Sasaki H; Tamura K; Takamatsu Y
[Ad] Endereço:Division of Oncology, Hematology, and Infectious Diseases, Department of Internal Medicine, Fukuoka University Hospital, Fukuoka, Japan.
[Ti] Título:Retrospective analysis of the efficacy and safety of eribulin therapy for metastatic breast cancer in daily practice.
[So] Source:Thorac Cancer;8(5):523-529, 2017 Sep.
[Is] ISSN:1759-7714
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Evidence of eribulin therapy for metastatic breast cancer (MBC) in clinical practice is not well documented. METHODS: We retrospectively analyzed the safety and efficacy of eribulin in 29 MBC patients from 2011 to 2016 at Fukuoka University Hospital. RESULTS: The median patient age, number of courses, total dose, and relative dose intensity were as follows: 65 years, five courses, 8.6 mg/m , and 75%, respectively. One patient achieved a complete response, (CR) six a partial response (PR), eight stable disease (SD) and 14 patients exhibited progressive disease. The objective response rate (ORR: CR + PR) was 24.1%, and the clinical benefit rate (CBR: CR + PR + SD) was 51.7%. The median progression-free survival was 90 days (95% confidence interval [CI] 67-126) and median overall survival was 264 days (95% CI 198-357). In patients who previously received 2-4 regimens, the ORR was 28.5% and the CBR was 57.1%. In patients who received 5-12 regimens, the ORR was 20% and the CBR was 45%. Chemotherapy was administered to 20 patients (69%) after eribulin administration, and the median overall survival rate of cases that achieved greater than a PR was 1088 days. The most frequent treatment-related grade 3/4 adverse events were neutropenia (55.2%), and febrile neutropenia (20.1%). Grade 3 peripheral neuropathy occurred in 13.8% of patients, but was not exacerbated even if present before treatment. CONCLUSION: Eribulin is effective for MBC patients who have received multiple chemotherapies. Neutropenia and febrile neutropenia may develop after heavy prior therapy.
[Mh] Termos MeSH primário: Antineoplásicos/administração & dosagem
Neoplasias da Mama/tratamento farmacológico
Furanos/administração & dosagem
Cetonas/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Antineoplásicos/efeitos adversos
Intervalo Livre de Doença
Esquema de Medicação
Feminino
Furanos/efeitos adversos
Seres Humanos
Cetonas/efeitos adversos
Meia-Idade
Metástase Neoplásica
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Furans); 0 (Ketones); LR24G6354G (eribulin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1111/1759-7714.12482


  2 / 12793 MEDLINE  
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[PMID]:29182213
[Au] Autor:Zeighami S; Mirmohammadrezaei S; Safi M; Falahchai SM
[Ad] Endereço:Assistant Professor, Dental Research Center, Dentistry Research Institute and Department of Prosthodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
[Ti] Título:The Effect of Core and Veneering Design on the Optical Properties of Polyether Ether Ketone.
[So] Source:Eur J Prosthodont Restor Dent;25(4):201-208, 2017 Dec 01.
[Is] ISSN:0965-7452
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study aimed to evaluate the effect of core shade and core and veneering thickness on color parameters and translucency of polyether ether ketone (PEEK). Sixty PEEK discs (0.5 and 1 mm in thickness) with white and dentine shades were veneered with A2 shade indirect composite resin with 0.5, 1 and 1.5 mm thickness (n=5). Cores without the veneering material served as controls for translucency evaluation. Color parameters were measured by a spectroradiometer. Color difference (ΔE00) and translucency parameters (TP) were computed. Data were analyzed using one-way ANOVA and Tukey's test (for veneering thickness) and independent t-test (for core shade and thickness) via SPSS 20.0 (p⟨0.05). Regarding the veneering thickness, white cores of 0.5 mm thickness showed significant differences in all color parameters. In white cores of 1 mm thickness and dentine cores of 0.5 and 1 mm thickness, there were statistically significant differences only in L∗, a∗ and h∗. The mean TP was significantly higher in all white cores of 1 mm thickness than dentine cores of 1 mm. Considering ΔE00=3.7 as clinically unacceptable, only three groups had higher mean ΔE00 values. Core shade, core thickness, and the veneering thickness affected the color and translucency of PEEK restorations.
[Mh] Termos MeSH primário: Materiais Biocompatíveis
Planejamento de Prótese Dentária
Facetas Dentárias
Cetonas
Polietilenoglicóis
Pigmentação em Prótese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Ketones); 30IQX730WE (Polyethylene Glycols); 31694-16-3 (polyetheretherketone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.1922/EJPRD_01720Zeighami08


  3 / 12793 MEDLINE  
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[PMID]:28602139
[Au] Autor:Liu RH; Wang DQ; Zhang PZ; Shao F; Chen LY; Huang HL; Lin S
[Ad] Endereço:a The College of Pharmacy , Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
[Ti] Título:A new diaryl 1, 2-diketone from the heartwood of Dalbergia latifolia.
[So] Source:Nat Prod Res;32(1):91-96, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new diaryl 1,2-diketone, named 1-(2,5-dihydroxy-4-methoxyphenyl)-2-phenylethane-1,2-dione (1), along with eight known compounds (2-9), were isolated from the heartwood of Dalbergia latifolia. They were identified on the basis of spectral data. Compounds 1-7 were obtained from the Dalbergia genus for the first time. Compounds 8 and 9 were firstly isolated from the plant. Compound 1 exhibited inactive against Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 21530 with the minimum inhibitory concentrations of 10.0 and 10.0 mg/mL, respectively.
[Mh] Termos MeSH primário: Antibacterianos/química
Dalbergia/química
Hidroquinonas/química
Cetonas/química
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Escherichia coli/efeitos dos fármacos
Hidroquinonas/farmacologia
Cetonas/farmacologia
Espectroscopia de Ressonância Magnética
Testes de Sensibilidade Microbiana
Estrutura Molecular
Staphylococcus aureus/efeitos dos fármacos
Madeira/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Hydroquinones); 0 (Ketones)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1338280


  4 / 12793 MEDLINE  
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[PMID]:29455554
[Au] Autor:El-Husseiny WM; El-Sayed MA; Abdel-Aziz NI; El-Azab AS; Ahmed ER; Abdel-Aziz AA
[Ad] Endereço:a Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy , Mansoura University , Mansoura , Egypt.
[Ti] Título:Synthesis, antitumour and antioxidant activities of novel α,ß-unsaturated ketones and related heterocyclic analogues: EGFR inhibition and molecular modelling study.
[So] Source:J Enzyme Inhib Med Chem;33(1):507-518, 2018 Dec.
[Is] ISSN:1475-6374
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:New α,ß-unsaturated ketones 4a,b; 5a-c; and 6a,b; as well as 4-H pyran 7; pyrazoline 8a,b; isoxazoline 9; pyridine 10-11; and quinoline-4-carboxylic acid 12a,b derivatives were synthesized and evaluated for in vitro antitumour activity against HepG2, MCF-7, HeLa, and PC-3 cancer cell lines. Antioxidant activity was investigated by the ability of these compounds to scavenge the 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS ). Compounds 6a, 6b, 7, and 8b exhibited potent antitumour activities against all tested cell lines with [IC ] ≅5.5-18.1 µΜ), in addition to significantly high ABTS scavenging activities. In vitro EGFR kinase assay for 6a, 6b, 7, and 8b as the most potent antitumour compounds showed that; compounds 6b, and 7 exhibited worthy EGFR inhibition activity with IC values of 0.56 and 1.6 µM, respectively, while compounds 6a and 8b showed good inhibition activity with IC values of 4.66 and 2.16 µM, respectively, compared with sorafenib reference drug (IC = 1.28 µM). Molecular modelling studies for compounds 6b, 7, and 8b were conducted to exhibit the binding mode towards EGFR kinase, which showed similar interaction with erlotinib.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Antioxidantes/farmacologia
Compostos Heterocíclicos/farmacologia
Cetonas/farmacologia
Inibidores de Proteínas Quinases/farmacologia
Receptor do Fator de Crescimento Epidérmico/antagonistas & inibidores
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Antineoplásicos/química
Antioxidantes/síntese química
Antioxidantes/química
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Compostos Heterocíclicos/síntese química
Compostos Heterocíclicos/química
Seres Humanos
Cetonas/síntese química
Cetonas/química
Modelos Moleculares
Estrutura Molecular
Inibidores de Proteínas Quinases/síntese química
Inibidores de Proteínas Quinases/química
Receptor do Fator de Crescimento Epidérmico/metabolismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Antioxidants); 0 (Heterocyclic Compounds); 0 (Ketones); 0 (Protein Kinase Inhibitors); EC 2.7.10.1 (Receptor, Epidermal Growth Factor)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180220
[St] Status:MEDLINE
[do] DOI:10.1080/14756366.2018.1434519


  5 / 12793 MEDLINE  
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[PMID]:29318252
[Au] Autor:Carvalho ATP; Dourado DFAR; Skvortsov T; de Abreu M; Ferguson LJ; Quinn DJ; Moody TS; Huang M
[Ad] Endereço:School of Chemistry and Chemical Engineering, Queen's University, David Keir Building, Stranmillis Road, Belfast BT9 5AG, Northern Ireland, UK. m.huang@qub.ac.uk.
[Ti] Título:Spatial requirement for PAMO for transformation of non-native linear substrates.
[So] Source:Phys Chem Chem Phys;20(4):2558-2570, 2018 Jan 24.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phenylacetone monooxygenase is the most stable and thermo-tolerant member of the Baeyer-Villiger monooxygenases family, and therefore it is an ideal candidate for the synthesis of industrially relevant ester or lactone compounds. However, its limited substrate scope has largely limited its industrial applications. Linear substrates are interesting from an industrial point of view, it is thus necessary to identify the essential spatial requirement for achieving high conversions for non-native linear substrates. Here using molecular dynamics simulations, we compared the conversion of a non-native linear substrate 2-octanone and the native substrate phenylacetone, catalyzed by the WT enzyme and a quadruple variant P253F/G254A/R258M/L443F that exhibits significantly improved activity towards 2-octanone. We uncovered that a remarkable movement of L289 is crucial for a reshaping of the active site of the quadruple variant so as to prevent the aliphatic substrate from moving away from the C4a-peroxyflavin, thus enabling it to keep a catalytically relevant pose during the oxygenation process. By performing steady-state kinetic analysis of two single-mutation variants at position 258, we further validated that the L289 reposition is attributed to the combined effect of quadruple mutations. In order to further explore the substrate scope of PAMO we also studied the binding of cyclopentanone and 2-phenylcyclohexanone, which are the typical substrates of CPMO in group I and CHMO in group III, respectively. Our study provides fundamental atomic-level insights in rational engineering of PAMO for wide applications in industrial biocatalysis, in particular, in the biotransformation of long-chain aliphatic oils into potential biodiesels.
[Mh] Termos MeSH primário: Oxigenases de Função Mista/metabolismo
[Mh] Termos MeSH secundário: Acetona/análogos & derivados
Acetona/química
Acetona/metabolismo
Actinobacteria/enzimologia
Sequência de Aminoácidos
Sítios de Ligação
Biocatálise
Domínio Catalítico
Cetonas/química
Cetonas/metabolismo
Cinética
Oxigenases de Função Mista/química
Oxigenases de Função Mista/genética
Simulação de Dinâmica Molecular
Mutagênese Sítio-Dirigida
Proteínas Recombinantes/biossíntese
Proteínas Recombinantes/química
Proteínas Recombinantes/isolamento & purificação
Alinhamento de Sequência
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ketones); 0 (Recombinant Proteins); 1364PS73AF (Acetone); EC 1.- (Mixed Function Oxygenases); J2G84H29AF (2-octanone); O7IZH10V9Y (1-phenyl-2-propanone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1039/c7cp07172h


  6 / 12793 MEDLINE  
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[PMID]:29240830
[Au] Autor:Warfel JD; Vandanmagsar B; Wicks SE; Zhang J; Noland RC; Mynatt RL
[Ad] Endereço:Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, United States of America.
[Ti] Título:A low fat diet ameliorates pathology but retains beneficial effects associated with CPT1b knockout in skeletal muscle.
[So] Source:PLoS One;12(12):e0188850, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Inhibiting fatty acid oxidation is one approach to lowering glucose levels in diabetes. Skeletal muscle specific Carnitine Palmitoyltransferase 1b knockout mice (Cpt1bm-/-) comprise a model of impaired fat oxidation; and have decreased fat mass and enhanced glucose disposal and muscle oxidative capacity compared to controls. However, unfavorable effects occur relative to controls when Cpt1bm-/- mice are fed a 25% fat diet, including decreased activity and fat free mass and increased intramuscular lipid and serum myoglobin. In this study we explore if a low fat, high carbohydrate diet can ablate the unfavorable effects while maintaining the favorable phenotype in Cpt1bm-/- mice. Mice were fed either 10% fat (low fat) or 25% fat (chow) diet. Body composition was measured biweekly and indirect calorimetry was performed. Low fat diet abolishes the decreased activity, fat, and fat free mass seen in Cpt1bm-/- mice fed chow diet. Low fat diet also reduces serum myoglobin levels in Cpt1bm-/- mice and diminishes differences in IGF-1 seen between Cpt1bm-/- mice and control mice fed chow diet. Glucose tolerance tests reveal that glucose clearance is improved in Cpt1bm-/- mice relative to controls regardless of diet, and serum analysis shows increased levels of muscle derived FGF21. Electron microscopic analyses and measurements of mRNA transcripts show increased intramuscular lipids, FGF21, mitochondrial and oxidative capacity markers regardless of diet. The favorable metabolic phenotype of Cpt1bm-/- mice therefore remains consistent regardless of diet; and a combination of a low fat diet and pharmacological inhibition of CPT1b may offer remedies to reduce blood glucose.
[Mh] Termos MeSH primário: Carnitina O-Palmitoiltransferase/genética
Dieta com Restrição de Gorduras
Músculo Esquelético/patologia
[Mh] Termos MeSH secundário: Animais
Ingestão de Energia
Ácidos Graxos não Esterificados/metabolismo
Fator de Crescimento Insulin-Like I/metabolismo
Cetonas/metabolismo
Camundongos
Camundongos Knockout
Músculo Esquelético/metabolismo
Mioglobina/metabolismo
Ganho de Peso
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids, Nonesterified); 0 (Ketones); 0 (Myoglobin); 67763-96-6 (Insulin-Like Growth Factor I); EC 2.3.1.21 (CPT1B protein, mouse); EC 2.3.1.21 (Carnitine O-Palmitoyltransferase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188850


  7 / 12793 MEDLINE  
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[PMID]:28741644
[Au] Autor:Bieszczad B; Gilheany DG
[Ad] Endereço:Centre for Synthesis and Chemical Biology, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland. declan.gilheany@ucd.ie.
[Ti] Título:Highly stereoselective construction of the C2 stereocentre of α-tocopherol (vitamin E) by asymmetric addition of Grignard reagents to ketones.
[So] Source:Org Biomol Chem;15(31):6483-6492, 2017 Aug 09.
[Is] ISSN:1477-0539
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Tertiary alcohol precursors of both C2 diastereoisomers of α-tocopherol were prepared in three ways by our recently reported asymmetric Grignard synthesis. The versatility of Grignard chemistry inherent in its three-way disconnection was exploited to allow the synthesis of three product grades: 77 : 23 dr (5 steps), 81 : 19 dr (5 steps) and 96 : 4 dr (7 steps, one gram scale) from readily available and abundant starting materials. The products were converted to their respective α-tocopherols in 3 steps, which allowed a definitive re-assignment of their absolute configurations.
[Mh] Termos MeSH primário: Cetonas/química
Vitaminas/síntese química
alfa-Tocoferol/síntese química
[Mh] Termos MeSH secundário: Álcoois/síntese química
Álcoois/química
Técnicas de Química Sintética
Indicadores e Reagentes
Cetonas/síntese química
Conformação Molecular
Estereoisomerismo
Vitaminas/química
alfa-Tocoferol/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alcohols); 0 (Indicators and Reagents); 0 (Ketones); 0 (Vitamins); H4N855PNZ1 (alpha-Tocopherol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1039/c7ob00751e


  8 / 12793 MEDLINE  
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[PMID]:29413989
[Au] Autor:Marques RA; Gomes AOCV; de Brito MV; Dos Santos ALP; da Silva GS; de Lima LB; Nunes FM; de Mattos MC; de Oliveira FCE; do Ó Pessoa C; de Moraes MO; de Fátima Â; Franco LL; Silva MM; Dantas MDA; Santos JCC; Figueiredo IM; da Silva-Júnior EF; de Aquino TM; de Araújo-Júnior JX; de Oliveira MCF; Leslie Gunatilaka AA
[Ad] Endereço:Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil; Northern Educational Union - UNINORTE, Rio Branco, Acre, Brazil.
[Ti] Título:Annonalide and derivatives: Semisynthesis, cytotoxic activities and studies on interaction of annonalide with DNA.
[So] Source:J Photochem Photobiol B;179:156-166, 2018 Feb.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The cytotoxic activity of the pimarane diterpene annonalide (1) and nine of its semisynthetic derivatives (2-10) was investigated against the human tumor cell lines HL-60 (leukemia), PC-3 (prostate adenocarcinoma), HepG2 (hepatocellular carcinoma), SF-295 (glioblastoma) and HCT-116 (colon cancer), and normal mouse fibroblast (L929) cells. The preparation of 2-10 involved derivatization of the side chain of 1 at C-13. Except for 2, all derivatives are being reported for the first time. Most of the tested compounds presented IC s below 4.0 µM, being considered potential antitumor agents. The structures of all new compounds were elucidated by spectroscopic analyses including 2D NMR and HRMS. Additionally, the interaction of annonalide (1) with ctDNA was evaluated using spectroscopic techniques, and the formation of a supramolecular complex with the macromolecule was confirmed. Competition assays with fluorescent probes (Hoechst and ethidium bromide) and theoretical studies confirmed that 1 interacts preferentially via DNA intercalation with stoichiometric ratio of 1:1 (1:ctDNA). The ΔG value was calculated as -28.24 kJ mol , and indicated that the interaction process occurs spontaneously. Docking studies revealed that van der Walls is the most important interaction in 1-DNA and EB-DNA complexes, and that both ligands (1 and EB) interact with the same DNA residues (DA6, DA17 and DT19).
[Mh] Termos MeSH primário: Ciclo-Octanos/química
DNA/química
Cetonas/química
[Mh] Termos MeSH secundário: Animais
Sítios de Ligação
Bovinos
Linhagem Celular Tumoral
Sobrevivência Celular
Ciclo-Octanos/síntese química
Ciclo-Octanos/toxicidade
DNA/metabolismo
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Cetonas/síntese química
Cetonas/toxicidade
Simulação de Acoplamento Molecular
Conformação de Ácido Nucleico
Espectrofotometria
Eletricidade Estática
Termodinâmica
Temperatura de Transição
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclooctanes); 0 (Ketones); 502-49-8 (cyclooctanone); 9007-49-2 (DNA); 91080-16-9 (calf thymus DNA)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


  9 / 12793 MEDLINE  
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[PMID]:29328616
[Au] Autor:Malivukovic A; Novakovic N; Lepic M; Minic L; Stepic N; Dordevic B; Rasulic L
[Ti] Título:Cranial reconstruction with prefabricated 3D implant after a gunshot injury: A case report.
[So] Source:Vojnosanit Pregl;73(8):783-7, 2016 Aug.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Introduction: Complex defects of skull bones with different etiology, still present the challenge in reconstructive surgery. The goldstandard for cranioplasty is the autologous calvarial bone graft removed during surgery which cannot be always applied, especially in gunshot wounds for sometimes complete bone destruction. Autologous reconstruction with split calvarial, rib bones or iliac bone graft is also possible. Materials routinely used for reconstructions like titanium mesh, polymethyl metacrylate (PMMA), and other have numerous disadvantages and limitations. Case report: We presented a patient with gunshot injury to the head with residual large bone defect in the frontal region, with involvement of the skull base, and open frontal sinus. After conservative treatment, six months after the injury, reconstruction of the residual bone defect was performed. The chosen material was computerdesigned PEEK-OPTIMA® implant, manufactured on the basis of MSCT scan. This material has not been used in this region so far. The postoperative and follow-up period of the next 12 months passed without surgical complications, neurological deficit, with satisfactory functional and aesthetic results. Conclusion: Implanted bone replacement was designed and manufactured precisely according to the skull defect, and we found it suitable for the treatment of complex defects of the cranium. Early results are in favor of this cranioplasty method over standardized materials. Therefore, this material is expected to become a method of choice for reconstructive surgery of bony defects of the face and skull especially in complex cases.
[Mh] Termos MeSH primário: Projeto Auxiliado por Computador
Próteses e Implantes
Procedimentos Cirúrgicos Reconstrutivos/métodos
Crânio/lesões
Crânio/cirurgia
Ferimentos por Arma de Fogo/cirurgia
[Mh] Termos MeSH secundário: Materiais Biocompatíveis
Estética
Seres Humanos
Cetonas
Masculino
Polietilenoglicóis
Procedimentos Cirúrgicos Reconstrutivos/instrumentação
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Ketones); 30IQX730WE (Polyethylene Glycols); 31694-16-3 (polyetheretherketone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150310043M


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[PMID]:29254587
[Au] Autor:Mastella E; Molinelli S; Magro G; Mirandola A; Russo S; Vai A; Mairani A; Choi K; Fiore MR; Fossati P; Cuzzocrea F; Gasbarrini A; Benazzo F; Boriani S; Valvo F; Orecchia R; Ciocca M
[Ad] Endereço:CNAO Foundation - National Centre for Oncological Hadron Therapy, I-27100 Pavia, Italy. Electronic address: edoardo.mastella@cnao.it.
[Ti] Título:Dosimetric characterization of carbon fiber stabilization devices for post-operative particle therapy.
[So] Source:Phys Med;44:18-25, 2017 Dec.
[Is] ISSN:1724-191X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The aim of this study was to evaluate the dosimetric impact caused by recently introduced carbon fiber reinforced polyetheretherketone (CF/PEEK) stabilization devices, in comparison with conventional titanium (Ti) implants, for post-operative particle therapy (PT). METHODS: As a first step, protons and carbon ions Spread-Out Bragg Peaks (SOBPs) were delivered to CF/PEEK and Ti screws. Transversal dose profiles were acquired with EBT3 films to evaluate beam perturbation. Effects on image quality and reconstruction artifacts were then investigated. CT scans of CF/PEEK and Ti implants were acquired according to our clinical protocol and Hounsfield Unit (HU) mean values were evaluated in three regions of interest. Implants and artifacts were then contoured in the sample CT scans, together with a target volume to simulate a spine tumor. Dose calculation accuracy was assessed by comparing optimized dose distributions with Monte Carlo simulations. In the end, the treatment plans of nine real patients (seven with CF/PEEK and two with Ti stabilization devices) were retrospectively analyzed to evaluate the dosimetric impact potentially occurring if improper management of the spine implant was carried out. RESULTS: As expected, CF/PEEK screw caused a very slight beam perturbation in comparison with Ti ones, leading to a lower degree of dose degradation in case of contouring and/or set-up uncertainties. Furthermore, CF/PEEK devices did not determine appreciable HU artifacts on CT images thus improving image quality and, as a final result, dose calculation accuracy. CONCLUSIONS: CF/PEEK spinal fixation devices resulted dosimetrically more suitable than commonly-used Ti implants for post-operative PT.
[Mh] Termos MeSH primário: Carbono/química
Radioterapia com Íons Pesados/instrumentação
[Mh] Termos MeSH secundário: Seres Humanos
Cetonas/química
Neoplasias/radioterapia
Neoplasias/cirurgia
Polietilenoglicóis/química
Período Pós-Operatório
Radiometria
Dosagem Radioterapêutica
Planejamento da Radioterapia Assistida por Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ketones); 0 (carbon fiber); 30IQX730WE (Polyethylene Glycols); 31694-16-3 (polyetheretherketone); 7440-44-0 (Carbon)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE



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