Base de dados : MEDLINE
Pesquisa : D02.522.296 [Categoria DeCS]
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  1 / 1721 MEDLINE  
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[PMID]:29225109
[Au] Autor:Khan V; Sharma S; Bhandari U; Ali SM; Haque SE
[Ad] Endereço:Department of Pharmacology, School of Pharmaceutical Education & Research (SPER), Jamia Hamdard, New Delhi 110062, India.
[Ti] Título:Raspberry ketone protects against isoproterenol-induced myocardial infarction in rats.
[So] Source:Life Sci;194:205-212, 2018 Feb 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIM: The cardioprotective role of raspberry ketone (RK) against isoproterenol (ISO)-induced myocardial infarction (MI) in rats was assessed. MATERIALS AND METHODS: Rats were randomly divided into Group I - Vehicle control; Group II - Toxic control ISO (85mg/kg, s.c.); Group III, IV and V - RK (50, 100 and 200mg/kg, respectively) with ISO; Group VI- RK (200mg/kg) alone; Group VII - Propranolol (10mg/kg) with ISO; and Group VIII - Propranolol (10mg/kg) alone. After twenty-four hours of the last dose, animals were sacrificed and creatine kinase-MB, lactate dehydrogenase, total cholesterol, triglycerides, high-density-lipoprotein, low-density-lipoprotein, very-low-density-lipoprotein, malondialdehyde, reduced glutathione, superoxide dismutase, catalase, Na , K -ATPase, nitric oxide, histopathological and immunohistochemical analysis (tumor necrosis factor-α and inducible nitric oxide synthase) were performed. KEY FINDINGS: Treatment with ISO significantly deviated the biochemical parameters from the normal levels, which were considerably restored by RK at 100 and 200mg/kg doses. 50mg/kg dose, however, did not demonstrate any significant cardioprotective action. The histopathological and immunohistochemical analysis further substantiated these findings. SIGNIFICANCE: Our study showed a dose-dependent reduction in oxidative stress, inflammation and dyslipidemia by RK in ISO-intoxicated rats, which signifies that RK from the European red raspberry plant might be a valuable entity for the management of MI.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Antioxidantes/uso terapêutico
Butanonas/uso terapêutico
Cardiotônicos/uso terapêutico
Infarto do Miocárdio/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Butanonas/química
Isoproterenol
Infarto do Miocárdio/induzido quimicamente
Infarto do Miocárdio/patologia
Miocárdio/patologia
Estresse Oxidativo/efeitos dos fármacos
PPAR alfa/agonistas
Ratos
Ratos Wistar
Rubus/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Butanones); 0 (Cardiotonic Agents); 0 (PPAR alpha); 7QY1MH15BG (raspberry ketone); L628TT009W (Isoproterenol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


  2 / 1721 MEDLINE  
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[PMID]:28859132
[Au] Autor:Akter H; Adnan S; Morelli R; Rempoulakis P; Taylor PW
[Ad] Endereço:Department of Biological Sciences, Macquarie University, Sydney, New South Wales, Australia.
[Ti] Título:Suppression of cuelure attraction in male Queensland fruit flies provided raspberry ketone supplements as immature adults.
[So] Source:PLoS One;12(8):e0184086, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tephritid fruit flies are amongst the most damaging insect pests of horticulture globally. Some of the key fruit fly species are managed using the sterile insect technique (SIT), whereby millions of sterile males are released to suppress reproduction of pest populations. Male annihilation technique (MAT), whereby sex specific lures are used to attract and kill males, is often used to reduce wild male numbers before SIT programs commence, providing released sterile males an increased numerical advantage. Overall program efficacy might be improved if MAT could be deployed simultaneously with SIT, continuously depleting fertile males from pest populations and replacing them with sterile males. However, such 'male replacement' requires a means of suppressing attraction of released sterile males to lures used in MAT. Previous studies have found that exposure of some fruit flies to lure compounds as mature adults can suppress subsequent response to those lures, raising the possibility of pre-release treatments. However, this approach requires holding flies until after maturation for treatment and then release. The present study takes a novel approach of exposing immature adult male Queensland fruit flies (Bactrocera tryoni, or 'Qfly') to raspberry ketone (RK) mixed in food, forcing these flies to ingest RK at ages far younger than they would naturally. After feeding on RK-supplemented food for two days after emergence, male Qflies exhibited a reduction in attraction to cuelure traps that lasted more than 20 days. This approach to RK exposure is compatible with current practises, in which Qflies are released as immature adults, and also yields advantages of accelerated reproductive development and increased mating propensity at young ages.
[Mh] Termos MeSH primário: Butanonas/farmacologia
Controle Biológico de Vetores
Reprodução/genética
Comportamento Sexual Animal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Suplementos Nutricionais
Feminino
Infertilidade Masculina/genética
Controle de Insetos
Masculino
Feromônios/farmacologia
Reprodução/efeitos dos fármacos
Tephritidae/genética
Tephritidae/crescimento & desenvolvimento
Tephritidae/patogenicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butanones); 0 (Pheromones); 7QY1MH15BG (raspberry ketone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184086


  3 / 1721 MEDLINE  
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[PMID]:28854647
[Au] Autor:Vargas RI; Souder SK; Morse JG; Grafton-Cardwell EE; Haviland DR; Kabashima JN; Faber BA; Mackey B; Nkomo E; Cook PJ; Stark JD
[Ad] Endereço:USDA-ARS, Daniel K. Inouye U.S. Pacific Basin Agricultural Research Center, 64 Nowelo St, Hilo, HI 96720.
[Ti] Título:Chemical Degradation of TMR Multilure Dispensers for Fruit Fly Detection Weathered Under California Climatic Conditions.
[So] Source:J Econ Entomol;110(4):1495-1500, 2017 Aug 01.
[Is] ISSN:1938-291X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Degradation models for multilure fruit fly trap dispensers were analyzed to determine their potential for use in large California detection programs. Solid three-component male lure TMR (trimedlure [TML], methyl eugenol [ME], raspberry ketone [RK]) dispensers impregnated with DDVP (2, 2-dichlorovinyl dimethyl phosphate) insecticide placed inside Jackson traps were weathered during summer (8 wk) and winter (12 wk) in five citrus-growing areas. Additionally, TMR wafers without DDVP, but with an insecticidal strip, were compared to TMR dispensers with DDVP. Weathered dispensers were sampled weekly and chemically analyzed. Percent loss of TML, the male lure for Ceratitis capitata (Wiedemann) Mediterranean fruit fly; ME, the male lure for Bactrocera dorsalis (Hendel), oriental fruit fly; RK, the male lure for Bactrocera cucurbitae (Coquillett), melon fly; and DDVP was measured. Based on regression analyses for the male lures, TML degraded the fastest followed by ME. Degradation of the more chemically stable RK was discontinuous, did not fit a regression model, but followed similar seasonal patterns. There were few location differences for all three male lures and DDVP. Dispensers degraded faster during summer than winter. An asymptotic regression model provided a good fit for % loss (ME, TML, and DDVP) for summer data. Degradation of DDVP in TMR dispensers was similar to degradation of DDVP in insecticidal strips. Based on these chemical analyses and prior bioassay results with wild flies, TMR dispensers could potentially be used in place of three individual male lure traps, reducing costs of fruit fly survey programs. Use of an insecticidal tape would not require TMR dispensers without DDVP to be registered with US-EPA.
[Mh] Termos MeSH primário: Diclorvós/química
Controle de Insetos/métodos
Feromônios/química
[Mh] Termos MeSH secundário: Animais
Butanonas/química
California
Ceratitis capitata/fisiologia
Ácidos Cicloexanocarboxílicos/química
Eugenol/análogos & derivados
Eugenol/química
Inseticidas/química
Masculino
Tephritidae/fisiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butanones); 0 (Cyclohexanecarboxylic Acids); 0 (Insecticides); 0 (Pheromones); 0 (insect attractants); 1H2MQB7WZ9 (trimedlure); 29T9VA6R7M (methyleugenol); 3T8H1794QW (Eugenol); 7QY1MH15BG (raspberry ketone); 7U370BPS14 (Dichlorvos)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1093/jee/tox159


  4 / 1721 MEDLINE  
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[PMID]:28783300
[Au] Autor:Fiorentini F; Romero E; Fraaije MW; Faber K; Hall M; Mattevi A
[Ad] Endereço:Austrian Centre of Industrial Biotechnology, c/o Department of Chemistry, University of Graz , Heinrichstrasse 28, 8010 Graz, Austria.
[Ti] Título:Baeyer-Villiger Monooxygenase FMO5 as Entry Point in Drug Metabolism.
[So] Source:ACS Chem Biol;12(9):2379-2387, 2017 Sep 15.
[Is] ISSN:1554-8937
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Flavin-containing monooxygenases (FMOs) are emerging as effective players in oxidative drug metabolism. Until recently, the functions of the five human FMO isoforms were mostly linked to their capability of oxygenating molecules containing soft N- and S-nucleophiles. However, the human FMO isoform 5 was recently shown to feature an atypical activity as Baeyer-Villiger monooxygenase. With the aim of evaluating such an alternative entry point in the metabolism of active pharmaceutical ingredients, we selected and tested drug molecules bearing a carbonyl group on an aliphatic chain. Nabumetone and pentoxifylline, two widely used pharmaceuticals, were thereby demonstrated to be efficiently oxidized in vitro by FMO5 to the corresponding acetate esters with high selectivity. The proposed pathways explain the formation of a predominant plasma metabolite of pentoxifylline as well as the crucial transformation of the pro-drug nabumetone into the pharmacologically active compound. Using the recombinant enzyme, the ester derivatives of both drugs were obtained in milligram amounts, purified, and fully characterized. This protocol can potentially be extended to other FMO5 candidate substrates as it represents an effective and robust bench-ready platform applicable to API screening and metabolite synthesis.
[Mh] Termos MeSH primário: Butanonas/metabolismo
Inibidores de Ciclo-Oxigenase 2/metabolismo
Oxigenases/metabolismo
Pentoxifilina/metabolismo
Inibidores de Fosfodiesterase/metabolismo
[Mh] Termos MeSH secundário: Seres Humanos
Peróxido de Hidrogênio/metabolismo
Oxirredução
Preparações Farmacêuticas/metabolismo
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butanones); 0 (Cyclooxygenase 2 Inhibitors); 0 (Pharmaceutical Preparations); 0 (Phosphodiesterase Inhibitors); BBX060AN9V (Hydrogen Peroxide); EC 1.13.- (Oxygenases); EC 1.14.13.8 (dimethylaniline monooxygenase (N-oxide forming)); LW0TIW155Z (nabumetone); SD6QCT3TSU (Pentoxifylline)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE
[do] DOI:10.1021/acschembio.7b00470


  5 / 1721 MEDLINE  
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[PMID]:28606512
[Au] Autor:Tsai YC; Yang BC; Peng WH; Lee YM; Yen MH; Cheng PY
[Ad] Endereço:Department of Obstetrics and Gynecology, Chi-Mei Medical Center, Tainan; Department of Medicine, Taipei Medical University, Taipei; Department of Sport Management, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
[Ti] Título:Heme oxygenase-1 mediates anti-adipogenesis effect of raspberry ketone in 3T3-L1 cells.
[So] Source:Phytomedicine;31:11-17, 2017 Jul 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Obesity is caused by excessive accumulation of body fat and is closely related to complex metabolic diseases. Raspberry ketone (RK), a major aromatic compound in red raspberry, was recently reported to possess anti-obesity effects. However, its mechanisms are unclear. AIM: Adipogenesis plays a critical role in obesity and, therefore, this study aimed to investigate the effect and mechanisms of action of RK on adipogenesis in 3T3-L1 preadipocytes. MATERIALS AND METHODS: 3T3-L1 preadipocytes were differentiated in medium containing insulin, dexamethasone, and 1-methyl-3-isobutylxanthine. Adipocyte lipid contents were determined using oil-red O staining while adipogenic transcription factor and lipogenic protein expressions were determined using western blotting. RESULTS: RK (300-400µM) strongly inhibited lipid accumulation during 3T3-L1 preadipocyte differentiation into adipocytes. RK reduced the CCAAT/enhancer-binding protein-α (C/EBP-α), peroxisome proliferation-activated receptor-γ (PPAR-γ), fatty acid synthase (FAS), and fatty acid-binding protein 4 (FABP4) expressions and increased heme oxygenase-1 (HO-1), Wnt10b, and ß-catenin expressions in 3T3-L1 adipocytes. Additionally, RK inhibited lipid accumulation, and adipogenic transcription factor and lipogenic protein expressions were all decreased by inhibiting HO-1 or ß-catenin using tin protoporphyrin (SnPP) or ß-catenin short-interfering RNA (siRNA), respectively. Furthermore, Wnt10b and ß-catenin expressions were negatively regulation by SnPP. CONCLUSION: RK may exert anti-adipogenic effects through modulation of the HO-1/Wnt/beta-catenin signaling pathway.
[Mh] Termos MeSH primário: Adipogenia/efeitos dos fármacos
Fármacos Antiobesidade/farmacologia
Butanonas/farmacologia
Heme Oxigenase-1/metabolismo
[Mh] Termos MeSH secundário: Células 3T3-L1/efeitos dos fármacos
Células 3T3-L1/metabolismo
Animais
Diferenciação Celular/efeitos dos fármacos
Camundongos
RNA Interferente Pequeno/farmacologia
Proteínas Wnt/metabolismo
Via de Sinalização Wnt/efeitos dos fármacos
beta Catenina/genética
beta Catenina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Obesity Agents); 0 (Butanones); 0 (CTNNB1 protein, mouse); 0 (RNA, Small Interfering); 0 (Wnt Proteins); 0 (Wnt10b protein, mouse); 0 (beta Catenin); 7QY1MH15BG (raspberry ketone); EC 1.14.14.18 (Heme Oxygenase-1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE


  6 / 1721 MEDLINE  
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[PMID]:28378858
[Au] Autor:Cotten BM; Diamond SA; Banh T; Hsiao YH; Cole RM; Li J; Simons CT; Bruno RS; Belury MA; Vodovotz Y
[Ad] Endereço:Department of Human Sciences, College of Education and Human Ecology, The Ohio State University, 1787 Neil Avenue, Columbus, OH 43210, USA. belury.1@osu.edu.
[Ti] Título:Raspberry ketone fails to reduce adiposity beyond decreasing food intake in C57BL/6 mice fed a high-fat diet.
[So] Source:Food Funct;8(4):1512-1518, 2017 Apr 19.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:As the incidence of obesity continues to increase, identifying novel nutritional therapies to enhance weight loss are needed. Raspberry ketone (RK; 4-(4-hydroxyphenyl) butan-2-one) is a bioactive phytochemical that is marketed as a weight loss supplement in the United States, yet there is scant scientific evidence demonstrating that RK promotes weight loss. The aim of the current study was to investigate the effect of RK on accumulation of adipose mass, hepatic lipid storage, and levels of plasma adiponectin in mice fed a high-fat (HF) diet. Mice were individually housed and fed a HF control diet (45% kcal from fat) for two weeks to induce weight gain, then assigned to HF control, high-dose (1.74% wt/wt) raspberry ketone (HRK), low-dose (0.25% wt/wt) raspberry ketone (LRK), or a pair-fed group (PF) fed similar food intake to LRK mice. Following five weeks of feeding, mice fed LRK and HRK diets showed reduced food intake and body weight compared to mice maintained on control diet. When normalized to body weight, mice fed HRK diet exhibited decreased inguinal fat mass and increased liver mass compared to the control group. Hepatic steatosis was lowest in mice fed HRK diet, whereas LRK diet did not have an effect when compared to the PF group. Plasma adiponectin concentration was unaffected by RK and pair-feeding. Our findings demonstrate that RK supplementation has limited benefit to adipose loss beyond reducing energy intake in mice fed a high-fat diet. The present study supports the need for appropriate study design when validating weight-loss supplements.
[Mh] Termos MeSH primário: Adiposidade/efeitos dos fármacos
Butanonas/administração & dosagem
Ingestão de Alimentos/efeitos dos fármacos
Obesidade/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Dieta Hiperlipídica/efeitos adversos
Gorduras na Dieta/metabolismo
Seres Humanos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Obesidade/metabolismo
Obesidade/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butanones); 0 (Dietary Fats); 7QY1MH15BG (raspberry ketone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1039/c6fo01831a


  7 / 1721 MEDLINE  
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[PMID]:28302311
[Au] Autor:Bayrak Ç; Taslimi P; Gülçin I; Menzek A
[Ad] Endereço:Department of Chemistry, Faculty of Science, Atatürk University, 25240 Erzurum, Turkey.
[Ti] Título:The first synthesis of 4-phenylbutenone derivative bromophenols including natural products and their inhibition profiles for carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase enzymes.
[So] Source:Bioorg Chem;72:359-366, 2017 Jun.
[Is] ISSN:1090-2120
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The first synthesis of (E)-4-(3-bromo-4,5-dihydroxyphenyl)but-3-en-2-one (1), (E)-4-(2-bromo-4,5-dihydroxyphenyl)but-3-en-2-one (2), and (E)-4-(2,3-dibromo-4,5-dihydroxyphenyl)but-3-en-2-one (3) was realized as natural bromophenols. Derivatives with mono OMe of 2 and 3 were obtained from the reactions of their derivatives with di OMe with AlCl . These novel 4-phenylbutenone derivatives were effective inhibitors of the cytosolic carbonic anhydrase I and II isoenzymes (hCA I and II), acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with K values in the range of 158.07-404.16pM for hCA I, 107.63-237.40pM for hCA II, 14.81-33.99pM for AChE and 5.64-19.30pM for BChE. The inhibitory effects of the synthesized novel 4-phenylbutenone derivatives were compared to acetazolamide as a clinical hCA I and II isoenzymes inhibitor and tacrine as a clinical AChE and BChE enzymes inhibitor.
[Mh] Termos MeSH primário: Produtos Biológicos/farmacologia
Butanonas/farmacologia
Inibidores da Anidrase Carbônica/farmacologia
Inibidores da Colinesterase/farmacologia
Fenóis/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Produtos Biológicos/síntese química
Produtos Biológicos/química
Butanonas/síntese química
Butanonas/química
Butirilcolinesterase/metabolismo
Anidrase Carbônica I/antagonistas & inibidores
Anidrase Carbônica I/metabolismo
Anidrase Carbônica II/antagonistas & inibidores
Anidrase Carbônica II/metabolismo
Inibidores da Anidrase Carbônica/síntese química
Inibidores da Anidrase Carbônica/química
Inibidores da Colinesterase/síntese química
Inibidores da Colinesterase/química
Relação Dose-Resposta a Droga
Seres Humanos
Estrutura Molecular
Fenóis/síntese química
Fenóis/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Products); 0 (Butanones); 0 (Carbonic Anhydrase Inhibitors); 0 (Cholinesterase Inhibitors); 0 (Phenols); B03X40BMT5 (benzylideneacetone); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase); EC 4.2.1.- (Carbonic Anhydrase I); EC 4.2.1.- (Carbonic Anhydrase II)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE


  8 / 1721 MEDLINE  
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[PMID]:28190807
[Au] Autor:Ichikawa S; Imura Y; Kawai T
[Ad] Endereço:Department of Industrial Chemistry, Tokyo University of Science.
[Ti] Título:Poly(styrene-co-acrylonitrile) Particles Prepared by Phase Inversion of W/O Emulsions.
[So] Source:J Oleo Sci;66(3):269-277, 2017 Mar 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:In this paper, we describe a particle preparation method that combines phase inversion of water in oil (W/O) emulsions with solidification of polymers dissolved in the emulsion droplets, induced by introducing a poor solvent, in order to prepare poly(styrene-co-acrylonitrile) (SAN) particles with a relatively narrow size distribution. W/O emulsions containing SAN are prepared by adding an aqueous solution of polyvinylalcohol (PVA) as a protective colloid into a methylethylketone (MEK) solution of SAN. Sufficient addition of the aqueous solution causes the precipitation of SAN particles from MEK followed by phase inversion from W/O emulsions to oil in water (O/W) emulsions. We also demonstrate that the use of sorbitan fatty acid esters as dispersion agents is effective for controlling size and polydispersity of SAN particles. They depend strongly on the concentrations and kinds of sorbitan fatty acid esters; a low concentration of sorbitan monolaurate resulted in an average particle size of 1.2 µm with a narrow size distribution.
[Mh] Termos MeSH primário: Resinas Acrílicas/química
Poliestirenos/química
[Mh] Termos MeSH secundário: Butanonas/química
Emulsificantes/química
Emulsões
Hexoses/química
Interações Hidrofóbicas e Hidrofílicas
Estrutura Molecular
Tamanho da Partícula
Álcool de Polivinil/química
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Butanones); 0 (Emulsifying Agents); 0 (Emulsions); 0 (Hexoses); 0 (Polystyrenes); 059QF0KO0R (Water); 6PT9KLV9IO (methylethyl ketone); 9002-89-5 (Polyvinyl Alcohol); 9003-54-7 (AS resin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170214
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess16176


  9 / 1721 MEDLINE  
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[PMID]:28132972
[Au] Autor:Hinoue M; Ishimatsu S; Fueta Y; Hori H
[Ad] Endereço:Department of Environmental Management, School of Health Sciences, University of Occupational and Environmental Health, Japan.
[Ti] Título:A new desorption method for removing organic solvents from activated carbon using surfactant.
[So] Source:J Occup Health;59(2):194-200, 2017 Mar 28.
[Is] ISSN:1348-9585
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: A new desorption method was investigated, which does not require toxic organic solvents. Efficient desorption of organic solvents from activated carbon was achieved with an ananionic surfactant solution, focusing on its washing and emulsion action. METHODS: Isopropyl alcohol (IPA) and methyl ethyl ketone (MEK) were used as test solvents. Lauryl benzene sulfonic acid sodium salt (LAS) and sodium dodecyl sulfate (SDS) were used as the surfactant. Activated carbon (100 mg) was placed in a vial and a predetermined amount of organic solvent was added. After leaving for about 24 h, a predetermined amount of the surfactant solution was added. After leaving for another 72 h, the vial was heated in an incubator at 60°C for a predetermined time. The organic vapor concentration was then determined with a frame ionization detector (FID)-gas chromatograph and the desorption efficiency was calculated. RESULTS: A high desorption efficiency was obtained with a 10% surfactant solution (LAS 8%, SDS 2%), 5 ml desorption solution, 60°C desorption temperature, and desorption time of over 24 h, and the desorption efficiency was 72% for IPA and 9% for MEK. Under identical conditions, the desorption efficiencies for another five organic solvents were investigated, which were 36%, 3%, 32%, 2%, and 3% for acetone, ethyl acetate, dichloromethane, toluene, and m-xylene, respectively. CONCLUSIONS: A combination of two anionic surfactants exhibited a relatively high desorption efficiency for IPA. For toluene, the desorption efficiency was low due to poor detergency and emulsification power.
[Mh] Termos MeSH primário: 2-Propanol/análise
Butanonas/análise
Dodecilsulfato de Sódio/administração & dosagem
Ácidos Sulfônicos/administração & dosagem
[Mh] Termos MeSH secundário: 2-Propanol/química
Butanonas/química
Técnicas de Química Analítica
Cromatografia Gasosa
Monitoramento Ambiental/métodos
Compostos Orgânicos/análise
Compostos Orgânicos/química
Solventes/análise
Tensoativos/administração & dosagem
Tolueno/análise
Tolueno/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butanones); 0 (Organic Chemicals); 0 (Solvents); 0 (Sulfonic Acids); 0 (Surface-Active Agents); 368GB5141J (Sodium Dodecyl Sulfate); 3FPU23BG52 (Toluene); 6PT9KLV9IO (methylethyl ketone); ND2M416302 (2-Propanol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE
[do] DOI:10.1539/joh.16-0214-OA


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[PMID]:28095954
[Au] Autor:Romoser AA; Scully RR; Limero TF; De Vera V; Cheng PF; Hand JJ; James JT; Ryder VE
[Ti] Título:Predicting Air Quality at First Ingress into Vehicles Visiting the International Space Station.
[So] Source:Aerosp Med Hum Perform;88(2):104-113, 2017 Feb 01.
[Is] ISSN:2375-6314
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: NASA regularly performs ground-based offgas tests (OGTs), which allow prediction of accumulated volatile pollutant concentrations at first entry on orbit, on whole modules and vehicles scheduled to connect to the International Space Station (ISS). These data guide crew safety operations and allow for estimation of ISS air revitalization systems impact from additional pollutant load. Since volatiles released from vehicle, module, and payload materials can affect crew health and performance, prediction of first ingress air quality is important. METHODS: To assess whether toxicological risk is typically over or underpredicted, OGT and first ingress samples from 10 vehicles and modules were compared. Samples were analyzed by gas chromatography and gas chromatography-mass spectrometry. The rate of pollutant accumulation was extrapolated over time. Ratios of analytical values and Spacecraft Maximum Allowable Concentrations were used to predict total toxicity values (T-values) at first entry. Results were also compared by compound. RESULTS: Frequently overpredicted was 2-butanone (9/10), whereas propanal (6/10) and ethanol (8/10) were typically underpredicted, but T-values were not substantially affected. Ingress sample collection delay (estimated by octafluoropropane introduced from ISS atmosphere) and T-value prediction accuracy correlated well (R2 = 0.9008), highlighting the importance of immediate air sample collection and accounting for ISS air dilution. DISCUSSION: Importantly, T-value predictions were conservative 70% of the time. Results also suggest that T-values can be normalized to octafluoropropane levels to adjust for ISS air dilution at first ingress. Finally, OGT and ingress sampling has allowed small leaks in vehicle fluid systems to be recognized and addressed.Romoser AA, Scully RR, Limero TF, De Vera V, Cheng PF, Hand JJ, James JT, Ryder VE. Predicting air quality at first ingress into vehicles visiting the International Space Station. Aerosp Med Hum Perform. 2017; 88(2):104-113.
[Mh] Termos MeSH primário: Medicina Aeroespacial
Poluição do Ar em Ambientes Fechados/análise
Ar/análise
Astronave
[Mh] Termos MeSH secundário: Aldeídos/análise
Butanonas/análise
Cromatografia Gasosa
Etanol/análise
Cromatografia Gasosa-Espectrometria de Massas
Gases/análise
Seres Humanos
Modelos Lineares
Voo Espacial
Estados Unidos
United States National Aeronautics and Space Administration
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aldehydes); 0 (Butanones); 0 (Gases); 3K9958V90M (Ethanol); 6PT9KLV9IO (methylethyl ketone); AMJ2B4M67V (propionaldehyde)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.3357/AMHP.4702.2017



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