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[PMID]:28414496
[Au] Autor:Newcombe DAL; Somogyi AA; Bochner F; White JM
[Ad] Endereço:School of Population Health, Faculty of Medical and Health Sciences.
[Ti] Título:Impaired psychomotor function and plasma methadone and levo-alpha-acetylmethadol (LAAM) concentrations in opioid-substitution patients.
[So] Source:Exp Clin Psychopharmacol;25(3):223-233, 2017 Jun.
[Is] ISSN:1936-2293
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tolerance to the psychomotor impairing effects of opioid drugs is expected to develop with repeated dosing, but may be incomplete. The relationship between plasma opioid concentration and psychomotor function in opioid-dependent patients was examined to determine whether impairment was more likely at the time of highest plasma drug concentration. Sixteen patients participating in a cross-over trial comparing methadone and LAAM completed a tracking task (OSPAT) 11 times over the dosing-interval for methadone (24-hrs) and LAAM (48-hrs). Venous blood was collected for the quantification of plasma (R)-(-)-methadone, LAAM, and nor-LAAM concentrations. The Digit Symbol Substitution Test (DSST) and Trail-Making Test were administered at the time of peak plasma concentration. Ten healthy controls (HCs) also participated. OSPAT scores (obtained for 15 patients) fluctuated significantly across the dosing-interval for both drugs and were lower in patients than HCs at the times of peak concentrations of (R)-(-)-methadone (1 hr: (mean difference; 95% CI) (2.13; 0.18-4.08); 2 hrs: (2.38; 0.48-4.28) postdosing) and LAAM (2 hrs: (1.81; 0.09-3.53), and 4 hrs (1.90: 0.9-3.71) postdosing). Within-participant analysis of the peak-change from baseline for OSPAT scores found that 10 of the 15 patients could be categorized as impaired on methadone and 9 on LAAM. No HCs were impaired. Patients performed worse on the DSST and Trails-A than HCs, but not on Trails-B. Results suggest that some patients receiving opioids long term may exhibit impairment at the time of highest plasma drug concentration. These patients should be made aware that their ability to undertake complex tasks may be affected. (PsycINFO Database Record
[Mh] Termos MeSH primário: Metadona/administração & dosagem
Acetato de Metadil/administração & dosagem
Transtornos Relacionados ao Uso de Opioides/reabilitação
Desempenho Psicomotor/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Tolerância a Medicamentos
Feminino
Seres Humanos
Masculino
Metadona/sangue
Acetato de Metadil/análogos & derivados
Acetato de Metadil/sangue
Meia-Idade
Tratamento de Substituição de Opiáceos/métodos
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
1477-39-0 (paracymethadol); L59OC40KWJ (Methadyl Acetate); UC6VBE7V1Z (Methadone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.1037/pha0000114


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[PMID]:24957634
[Au] Autor:Minozzi S; Amato L; Bellisario C; Davoli M
[Ad] Endereço:Department of Epidemiology, Lazio Regional Health Service, Via di Santa Costanza, 53, Rome, Italy, 00198.
[Ti] Título:Maintenance treatments for opiate -dependent adolescents.
[So] Source:Cochrane Database Syst Rev;(6):CD007210, 2014 Jun 24.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The scientific literature examining effective treatments for opioid-dependent adults clearly indicates that pharmacotherapy is a necessary and acceptable component. Nevertheless, no reviews have been published that systematically assess the effectiveness of pharmacological maintenance treatment in adolescents. OBJECTIVES: To assess the effectiveness of any maintenance treatment alone or in combination with psychosocial intervention compared to no intervention, other pharmacological intervention or psychosocial interventions for retaining adolescents in treatment, reducing the use of substances and improving health and social status. SEARCH METHODS: We searched the Cochrane Drugs and Alcohol Group's Trials Register (January 2014), the Cochrane Central Register of Controlled Trials (2014, Issue 1), PubMed (January 1966 to January 2014), EMBASE (January 1980 to January 2014), CINAHL (January 1982 to January 2014), Web of Science (1991 to January 2014) and reference lists of articles. SELECTION CRITERIA: Randomised and controlled clinical trials of any maintenance pharmacological interventions either alone or associated with psychosocial intervention compared with no intervention, placebo, other pharmacological intervention, pharmacological detoxification or psychosocial intervention in adolescents (13 to 18 years). DATA COLLECTION AND ANALYSIS: We used the standard methodological procedures expected by The Cochrane Collaboration. MAIN RESULTS: We included two trials involving 189 participants. One study, with 35 participants, compared methadone with levo-alpha-acetylmethadol (LAAM) for maintenance treatment lasting 16 weeks, after which patients were detoxified. The other study, with 154 participants, compared maintenance treatment with buprenorphine-naloxone and detoxification with buprenorphine. We did not perform meta-analysis because the two studies assessed different comparisons.In the study comparing methadone and LAAM, the authors declared that there was no difference in the use of a substance of abuse or social functioning (data not shown). The quality of the evidence was very low. No side effects, such as nausea, vomiting, constipation, weakness or fatigue, were reported by study participants.In the comparison between buprenorphine maintenance and buprenorphine detoxification, maintenance treatment appeared to be more efficacious in retaining patients in treatment (drop-out risk ratio (RR) 0.37; 95% confidence interval (CI) 0.26 to 0.54), but not in reducing the number of patients with a positive urine test at the end of the study (RR 0.97; 95% CI 0.78 to 1.22). Self reported opioid use at one-year follow-up was significantly lower in the maintenance group, even though both groups reported a high level of opioid use (RR 0.73; 95% CI 0.57 to 0.95). More patients in the maintenance group were enrolled in other addiction treatment programmes at 12-month follow-up (RR 1.33; 95% CI 0.94 to 1.88). The quality of the evidence was low. No serious side effects attributable to buprenorphine-naloxone were reported by study participants and no patients were removed from the study due to side effects. The most common side effect was headache, which was reported by 16% to 21% of patients in both groups AUTHORS' CONCLUSIONS: It is difficult to draft conclusions on the basis of only two trials. One of the possible reasons for the lack of evidence could be the difficulty of conducting trials with young people for practical and ethical reasons.There is an urgent need for further randomised controlled trials comparing maintenance treatment with detoxification treatment or psychosocial treatment alone before carrying out studies that compare different pharmacological maintenance treatments. These studies should have long follow-up and measure relapse rates after the end of treatment and social functioning (integration at school or at work, family relationships).
[Mh] Termos MeSH primário: Quimioterapia de Manutenção/métodos
Entorpecentes/uso terapêutico
Tratamento de Substituição de Opiáceos/métodos
Transtornos Relacionados ao Uso de Opioides/reabilitação
[Mh] Termos MeSH secundário: Adolescente
Buprenorfina/uso terapêutico
Seres Humanos
Metadona/uso terapêutico
Acetato de Metadil/uso terapêutico
Naloxona/uso terapêutico
Ensaios Clínicos Controlados Aleatórios como Assunto
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Narcotics); 36B82AMQ7N (Naloxone); 40D3SCR4GZ (Buprenorphine); L59OC40KWJ (Methadyl Acetate); UC6VBE7V1Z (Methadone)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:160602
[Lr] Data última revisão:
160602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140625
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD007210.pub3


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[PMID]:24935116
[Au] Autor:Sai KK; Fan J; Tu Z; Zerkel P; Mach RH; Kharasch ED
[Ad] Endereço:Department of Radiology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Radiology, Wake Forest School of Medicine, 1 Medical Center Blvd, Winston Salem, NC 27157, USA.
[Ti] Título:Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM).
[So] Source:Appl Radiat Isot;91:135-40, 2014 Sep.
[Is] ISSN:1872-9800
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Long-acting opioid agonists methadone and l-α-acetylmethadol (LAAM) prevent withdrawal in opioid-dependent persons. Attempts to synthesize [(11)C]-methadone for PET evaluation of brain disposition were unsuccessful. Owing, however, to structural and pharmacologic similarities, we aimed to develop [(11)C]LAAM as a PET ligand to probe the brain exposure of long-lasting opioids in humans. This manuscript describes [(11)C]LAAM synthesis and its biodistribution in mice. The radiochemical synthetic strategy afforded high radiochemical yield, purity and specific activity, thereby making the synthesis adaptable to automated modules.
[Mh] Termos MeSH primário: Radioisótopos de Carbono/química
Acetato de Metadil/síntese química
Acetato de Metadil/farmacocinética
Compostos Radiofarmacêuticos/síntese química
Compostos Radiofarmacêuticos/farmacocinética
[Mh] Termos MeSH secundário: Animais
Encéfalo/metabolismo
Masculino
Camundongos
Tomografia por Emissão de Pósitrons
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Carbon Radioisotopes); 0 (Radiopharmaceuticals); L59OC40KWJ (Methadyl Acetate)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140618
[St] Status:MEDLINE


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[PMID]:24076207
[Au] Autor:Hamilton KL; Harris AC; Gewirtz JC
[Ad] Endereço:Department of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455, USA. Electronic address: hamiltonk@uwstout.edu.
[Ti] Título:Affective and neuroendocrine effects of withdrawal from chronic, long-acting opiate administration.
[So] Source:Brain Res;1538:73-82, 2013 Nov 13.
[Is] ISSN:1872-6240
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Although the long-acting opiate methadone is commonly used to treat drug addiction, relatively little is known about the effects of withdrawal from this drug in preclinical models. The current study examined affective, neuroendocrine, and somatic signs of withdrawal from the longer-acting methadone derivative l-alpha-acetylmethydol (LAAM) in rats. Anxiety-like behavior during both spontaneous and antagonist-precipitated withdrawal was measured by potentiation of the startle reflex. Withdrawal elevated corticosterone and somatic signs and blunted circadian variations in baseline startle responding. In addition, fear to an explicit, Pavlovian conditioned stimulus (fear-potentiated startle) was enhanced. These data suggest that anxiety-like behavior as measured using potentiated startle responding does not emerge spontaneously during withdrawal from chronic opiate exposure - in contrast to withdrawal from acute drug exposure - but rather is manifested as exaggerated fear in response to explicit threat cues.
[Mh] Termos MeSH primário: Afeto/fisiologia
Acetato de Metadil/efeitos adversos
Entorpecentes/efeitos adversos
Sistemas Neurossecretores/fisiologia
Reflexo de Sobressalto/fisiologia
Síndrome de Abstinência a Substâncias/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Corticosterona/sangue
Masculino
Naloxona/farmacologia
Antagonistas de Entorpecentes/farmacologia
Ratos
Ratos Sprague-Dawley
Reflexo de Sobressalto/efeitos dos fármacos
Síndrome de Abstinência a Substâncias/sangue
Síndrome de Abstinência a Substâncias/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Narcotic Antagonists); 0 (Narcotics); 36B82AMQ7N (Naloxone); L59OC40KWJ (Methadyl Acetate); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1406
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131001
[St] Status:MEDLINE


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[PMID]:23093298
[Au] Autor:Michel-Lauter B; Maier C; Schwarzer A
[Ad] Endereço:Abteilung für Schmerztherapie, Klinik für Anaesthesiologie, Intensiv-, Palliativ- und Schmerzmedizin, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil Bochum GmbH, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Deutschland. beate.michel-lauter@ruhr-uni-bochum.de
[Ti] Título:[Accidental levomethadone intoxication in a palliative patient].
[Ti] Título:Akzidentielle Levomethadonintoxikation bei einer Palliativpatientin..
[So] Source:Schmerz;26(6):721-3, 2012 Dec.
[Is] ISSN:1432-2129
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:Levomethadone is a strong opioid which is used rarely in the treatment of special pain syndromes in Germany. A main field for the usage of Levomethadone, which has be applied as a oral fluid, is the opioid replacement therapy of heroin-addicts. Due to the long plasma half life and its high inter-individual variability, the application implies a risk of cumulation leading to an overdosage. It is not recommended to use a fixed equianalgesic formula for the dosage conversion from other opioids. The conversion starts with a low start dose, an individual titration follows. In this case-report, the difficulty of cumulation, inaccurate drug dispensary and the characteristic of dosage calculation of levomethadone is discussed.
[Mh] Termos MeSH primário: Analgésicos Opioides/toxicidade
Neoplasias Ósseas/secundário
Neoplasias Ósseas/terapia
Neoplasias da Mama/terapia
Substituição de Medicamentos
Fraturas Espontâneas/terapia
Erros de Medicação
Acetato de Metadil/toxicidade
Dor Intratável/tratamento farmacológico
Cuidados Paliativos
Ossos Pélvicos/lesões
[Mh] Termos MeSH secundário: Analgésicos Opioides/administração & dosagem
Transtornos da Consciência/induzido quimicamente
Relação Dose-Resposta a Droga
Embalagem de Medicamentos
Feminino
Seres Humanos
Acetato de Metadil/administração & dosagem
Meia-Idade
Medição da Dor/efeitos dos fármacos
[Pt] Tipo de publicação:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid); L59OC40KWJ (Methadyl Acetate)
[Em] Mês de entrada:1311
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121025
[St] Status:MEDLINE
[do] DOI:10.1007/s00482-012-1229-2


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[PMID]:22263711
[Au] Autor:Gryczynski J; Kinlock TW; Kelly SM; O'Grady KE; Gordon MS; Schwartz RP
[Ad] Endereço:Friends Research Institute, Baltimore, Maryland 21201, USA. jgryczynski@friendsresearch.org
[Ti] Título:Opioid agonist maintenance for probationers: patient-level predictors of treatment retention, drug use, and crime.
[So] Source:Subst Abus;33(1):30-9, 2012.
[Is] ISSN:1547-0164
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study examined outcomes and their predictors among 181 probationers enrolling in opioid agonist maintenance with methadone or levo-alpha-acetylmethadol (LAAM). Participants were interviewed at treatment entry and 2-, 6-, and 12-month follow-ups. Treatment retention and frequency of heroin use, cocaine use, and income-generating criminal activity were examined using survival and longitudinal analyses. Participants reported marked reductions in drug use and crime relative to treatment entry. A number of patient characteristics associated with various outcomes were identified. The findings support engaging probationers in treatment and highlight patient factors that might influence outcomes.
[Mh] Termos MeSH primário: Analgésicos Opioides/uso terapêutico
Metadona/uso terapêutico
Acetato de Metadil/uso terapêutico
Transtornos Relacionados ao Uso de Opioides/tratamento farmacológico
Prisioneiros
[Mh] Termos MeSH secundário: Adulto
Analgésicos Opioides/agonistas
Baltimore
Crime/estatística & dados numéricos
Feminino
Dependência de Heroína/tratamento farmacológico
Dependência de Heroína/reabilitação
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
Transtornos Relacionados ao Uso de Opioides/reabilitação
Cooperação do Paciente
Modelos de Riscos Proporcionais
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Analgesics, Opioid); L59OC40KWJ (Methadyl Acetate); UC6VBE7V1Z (Methadone)
[Em] Mês de entrada:1205
[Cu] Atualização por classe:150330
[Lr] Data última revisão:
150330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120124
[St] Status:MEDLINE
[do] DOI:10.1080/08897077.2011.616816


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[PMID]:22021567
[Au] Autor:Kurt TL
[Ti] Título:Opioids, QTc prolongation, and torsades.
[So] Source:J Clin Pharmacol;52(10):1614, 2012 Oct.
[Is] ISSN:1552-4604
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Analgésicos Opioides/efeitos adversos
Dextropropoxifeno/efeitos adversos
Síndrome do QT Longo/induzido quimicamente
Acetato de Metadil/efeitos adversos
Torsades de Pointes/induzido quimicamente
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Analgesics, Opioid); L59OC40KWJ (Methadyl Acetate); S2F83W92TK (Dextropropoxyphene)
[Em] Mês de entrada:1301
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111025
[St] Status:MEDLINE


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[PMID]:20667673
[Au] Autor:Gray TR; Dams R; Choo RE; Jones HE; Huestis MA
[Ad] Endereço:Chemistry and Drug Metabolism, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd, Suite 200, Room 05A721, Baltimore, MD 21224, USA. teresa.r.gray@gmail.com
[Ti] Título:Methadone disposition in oral fluid during pharmacotherapy for opioid-dependence.
[So] Source:Forensic Sci Int;206(1-3):98-102, 2011 Mar 20.
[Is] ISSN:1872-6283
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Oral fluid testing is widely used for detecting drug exposure, but data describing methadone and metabolites in oral fluid during pharmacotherapy for opioid-dependence are relatively limited. METHODS: 414 oral fluid specimens from 16 opioid-dependent pregnant women receiving daily methadone were analyzed for methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), and methadol by liquid chromatography-mass spectrometry. RESULTS: All oral fluid specimens contained methadone greater than 1 ng/mL; 88% were positive for EDDP and 12% for methadol. Over 95% of oral fluid specimens exceeded the 20 ng/mL methadone cutoff set by the European Driving Under the Influence of Drugs, Alcohol and Medicines (DRUID) study. Methadone and EDDP oral fluid concentrations were highly variable within and between participants, did not predict methadone dose, but were negatively correlated with pH. CONCLUSION: Methadone was readily identified in oral fluid at concentrations greater than 20 ng/mL following daily 30-110 mg/day methadone pharmacotherapy. As no specimens contained only EDDP or methadol, there was no advantage to including these analytes for identification of methadone exposure. As nearly all oral fluid specimens from methadone-maintained patients exceeded the DRUID guideline, the 20 ng/mL cutoff appears to be sensitive enough to detect daily methadone exposure; however, additional indicators of behavioral and/or motor impairment would be necessary to provide evidence of driving impairment.
[Mh] Termos MeSH primário: Metadona/análise
Entorpecentes/análise
Tratamento de Substituição de Opiáceos
Transtornos Relacionados ao Uso de Opioides/tratamento farmacológico
Saliva/química
[Mh] Termos MeSH secundário: Cromatografia Líquida
Feminino
Seres Humanos
Concentração de Íons de Hidrogênio
Espectrometria de Massas
Metadona/uso terapêutico
Acetato de Metadil/análise
Entorpecentes/uso terapêutico
Gravidez
Pirrolidinas/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Narcotics); 0 (Pyrrolidines); L59OC40KWJ (Methadyl Acetate); UC6VBE7V1Z (Methadone); Z3LC48U94I (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine)
[Em] Mês de entrada:1107
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100730
[St] Status:MEDLINE
[do] DOI:10.1016/j.forsciint.2010.06.031


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[PMID]:20616264
[Au] Autor:Cohen J
[Ti] Título:No opiate substitutes for the masses of IDUs.
[So] Source:Science;329(5988):165-7, 2010 Jul 09.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Infecções por HIV/prevenção & controle
Redução do Dano
Metadona/administração & dosagem
Entorpecentes/administração & dosagem
Transtornos Relacionados ao Uso de Opioides/reabilitação
Abuso de Substâncias por Via Intravenosa/reabilitação
[Mh] Termos MeSH secundário: Feminino
Infecções por HIV/complicações
Infecções por HIV/transmissão
Seres Humanos
Masculino
Acetato de Metadil/administração & dosagem
Programas de Troca de Agulhas
Federação Russa/epidemiologia
Abuso de Substâncias por Via Intravenosa/complicações
Ucrânia/epidemiologia
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (Narcotics); L59OC40KWJ (Methadyl Acetate); UC6VBE7V1Z (Methadone)
[Em] Mês de entrada:1007
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100710
[St] Status:MEDLINE
[do] DOI:10.1126/science.329.5988.165


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[PMID]:20163389
[Au] Autor:Mancino MJ; McGaugh J; Feldman Z; Poling J; Oliveto A
[Ad] Endereço:Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. mjmancino@uams.edu
[Ti] Título:Effect of PTSD diagnosis and contingency management procedures on cocaine use in dually cocaine- and opioid-dependent individuals maintained on LAAM: a retrospective analysis.
[So] Source:Am J Addict;19(2):169-77, 2010 Mar-Apr.
[Is] ISSN:1521-0391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This randomized clinical trial retrospectively examined the effect of post-traumatic stress disorder (PTSD) and contingency management (CM) on cocaine use in opioid and cocaine dependent individuals maintained on high or low-dose LAAM randomly assigned to CM or a yoked-control condition. Cocaine-positive urines decreased more rapidly over time in those without PTSD versus those with PTSD in the noncontingency condition. In participants with PTSD, CM resulted in fewer cocaine-positive urines compared to the noncontingent condition. This suggests that CM may help improve the potentially worse outcomes in opioid- and cocaine-dependent individuals with PTSD compared to those without PTSD. (Am J Addict 2010;00:1-9).
[Mh] Termos MeSH primário: Terapia Comportamental/métodos
Transtornos Relacionados ao Uso de Cocaína/tratamento farmacológico
Transtornos Relacionados ao Uso de Cocaína/terapia
Acetato de Metadil/administração & dosagem
Transtornos Relacionados ao Uso de Opioides/tratamento farmacológico
Transtornos Relacionados ao Uso de Opioides/terapia
Transtornos de Estresse Pós-Traumáticos/tratamento farmacológico
Transtornos de Estresse Pós-Traumáticos/terapia
[Mh] Termos MeSH secundário: Adulto
Transtornos Relacionados ao Uso de Cocaína/complicações
Transtornos Relacionados ao Uso de Cocaína/urina
Terapia Combinada/psicologia
Diagnóstico Duplo (Psiquiatria)/estatística & dados numéricos
Relação Dose-Resposta a Droga
Feminino
Seres Humanos
Masculino
Transtornos Relacionados ao Uso de Opioides/complicações
Cooperação do Paciente/estatística & dados numéricos
Estudos Retrospectivos
Transtornos de Estresse Pós-Traumáticos/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
L59OC40KWJ (Methadyl Acetate)
[Em] Mês de entrada:1007
[Cu] Atualização por classe:161025
[Lr] Data última revisão:
161025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100219
[St] Status:MEDLINE
[do] DOI:10.1111/j.1521-0391.2009.00025.x



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