Base de dados : MEDLINE
Pesquisa : D02.522.720 [Categoria DeCS]
Referências encontradas : 672 [refinar]
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[PMID]:27773607
[Au] Autor:Iizuka-Furukawa S; Isogai A; Kusaka K; Fujii T; Wakai Y
[Ad] Endereço:Kizakura Co. Ltd., 223 Shioya-machi, Fushimi-ku, Kyoto 612-8046, Japan; National Research Institute of Brewing, 3-7-1 Kagamiyama, Higashi-hiroshima 739-0046, Japan. Electronic address: s.iizuka@nrib.go.jp.
[Ti] Título:Identification of 4-mercapto-4-methylpentan-2-one as the characteristic aroma of sake made from low-glutelin rice.
[So] Source:J Biosci Bioeng;123(2):209-215, 2017 Feb.
[Is] ISSN:1347-4421
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The grassy characteristic aroma perceived in brewed sake made from low-glutelin rice (Oryza sativa L. Mizuhonoka) was examined by gas chromatography-olfactometry and gas chromatography-mass spectrometry. By comparing the odor properties and Kovats retention indices to those of standard compounds, 4-mercapto-4-methylpentan-2-one (4MMP) was found to contribute to the characteristic aroma. Sake brewing using Mizuhonoka, low-glutelin rice, and Gin-ohmi (a control) revealed that 4MMP concentrations in Mizuhonoka sake samples were higher than those in Gin-ohmi samples over the fermentation period. The concentration in final Mizuhonoka sake was twice that of Gin-ohmi. To investigate the mechanism of 4MMP formation, the putative precursors, 4-S-cycteinyl-4-methylpentan-2-one (cys-4MMP) and 4-S-glutathionyl-4-methylpentan-2-one (glut-4MMP), in sake and its materials (rice and koji) were analyzed by ultra-performance liquid chromatography tandem mass-spectrometry. Cys-4MMP was not detected in all samples, while glut-4MMP was present in sake and its materials. The glut-4MMP concentration in sake was lower than that in Gin-ohmi over nearly the entire fermentation period, suggesting that conversion of the precursors to 4MMP was more effective in the mash of low-glutelin rice Mizuhonoka than in Gin-ohmi. The release of 4MMP during alcoholic fermentation from a model medium containing its precursors was examined. While no 4MMP release was observed in the control (no addition), with the addition of its precursors, the release of 4MMP increased as fermentation progressed. It was suggested that 4MMP was generated from both cys- and glut-4MMP by sake yeast. The perception threshold of 4MMP in sake was determined as 1.2 ng/L.
[Mh] Termos MeSH primário: Bebidas Alcoólicas/análise
Aromatizantes
Odorantes
Oryza/química
Pentanonas/isolamento & purificação
Pentanonas/metabolismo
Compostos de Sulfidrila/isolamento & purificação
Compostos de Sulfidrila/metabolismo
[Mh] Termos MeSH secundário: Etanol/análise
Etanol/metabolismo
Fermentação
Aromatizantes/análise
Aromatizantes/metabolismo
Cromatografia Gasosa-Espectrometria de Massas/métodos
Glutationa/análogos & derivados
Glutationa/metabolismo
Glutens/metabolismo
Odorantes/análise
Oryza/metabolismo
Pentanonas/análise
Saccharomyces cerevisiae/metabolismo
Compostos de Sulfidrila/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4-S-glutathionyl-4-methylpentan-2-one); 0 (4-mercapto-4-methyl-pentan-2-one); 0 (Flavoring Agents); 0 (Pentanones); 0 (Sulfhydryl Compounds); 3K9958V90M (Ethanol); 8002-80-0 (Glutens); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28915419
[Au] Autor:van de Merbel NC; Bronsema KJ; Gorman SH; Bakhtiar R
[Ad] Endereço:Bioanalytical Laboratory, PRA Health Sciences, Amerikaweg 18, 9407 TK, Assen, The Netherlands; Analytical Biochemistry, Department of Pharmacy, University of Groningen, A. Deusinglaan 1, 9700 AV, Groningen, The Netherlands. Electronic address: merbelnicovande@prahs.com.
[Ti] Título:Sensitivity improvement of the LC-MS/MS quantification of carbidopa in human plasma and urine by derivatization with 2,4-pentanedione.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1064:62-67, 2017 Oct 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The reliable quantification of carbidopa in biological samples at low concentrations is challenging because of the polar and highly unstable nature of the compound. In this paper, LC-MS/MS methods are described for the determination of carbidopa in 50µL of human plasma and 25µL of human urine in the concentration ranges 1-1,000ng/mL and 100-50,000ng/mL, respectively. After a simple protein precipitation (plasma) or dilution (urine) step, carbidopa is derivatized at its hydrazine moiety by reaction for one hour with 2,4-pentanedione under acidic conditions and at 40°C. The product is a relatively non-polar molecule that is suitable for reversed-phase liquid chromatography (3.5min run time) with detection by tandem mass spectrometry with electrospray ionization. A stable-isotope labeled internal standard is used for response normalization. Precision, accuracy and selectivity of the methods meet the criteria of international guidelines for bioanalytical method validation. Acidification of urine to pH 1.5 and the addition of two anti-oxidants (5mg/mL sodium metabisulfite and 1mg/mL butylated hydroxytoluene) to plasma, in combination with sampling and analysis on ice and under yellow light, ensure sufficient stability of carbidopa. The methods were successfully used to determine plasma pharmacokinetics and urinary excretion of carbidopa in healthy volunteers after a single 37.5mg oral dose.
[Mh] Termos MeSH primário: Carbidopa/sangue
Carbidopa/urina
Cromatografia Líquida/métodos
Pentanonas/química
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Carbidopa/farmacocinética
Seres Humanos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pentanones); 46R950BP4J (acetylacetone); MNX7R8C5VO (Carbidopa)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE


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[PMID]:28779618
[Au] Autor:Chen Z; Song X; Zhang S; Wu B; Zhang G; Pan B
[Ad] Endereço:State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, PR China.
[Ti] Título:Acetylacetone as an efficient electron shuttle for concerted redox conversion of arsenite and nitrate in the opposite direction.
[So] Source:Water Res;124:331-340, 2017 Nov 01.
[Is] ISSN:1879-2448
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The redox conversion of arsenite and nitrate has direct effects on their potential environment risks. Due to the similar reduction potentials, there are few technologies that can simultaneously oxidize arsenite and reduce nitrate in one process. Here, we demonstrate that a diketone-mediated photochemical process could efficiently do this. A combined experimental and theoretical investigation was conducted to elucidate the mechanisms behind the redox conversion in the UV/acetylacetone (AA) process. Our key finding is that UV irradiation significantly changed the redox potential of AA. The excited AA, (AA)*, acted as a semiquinone radical-like electron shuttle. For arsenite oxidation, the efficiency of (AA)* was 1-2 orders of magnitude higher than those of quinone-type electron shuttles, whereas the consumption of AA was 2-4 orders of magnitude less than those of benzonquinones. The oxidation of arsenite and reduction of nitrate could be both accelerated when they existed together in UV/AA process. The results indicate that small diketones are some neglected but potent electron shuttles of great application potential in regulating aquatic redox reactions with the combination of UV irradiation.
[Mh] Termos MeSH primário: Arsenitos/química
Pentanonas/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Elétrons
Nitratos
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenites); 0 (Nitrates); 0 (Pentanones); 0 (Water Pollutants, Chemical); 46R950BP4J (acetylacetone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170806
[St] Status:MEDLINE


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[PMID]:28645576
[Au] Autor:Luethi D; Liechti ME; Krähenbühl S
[Ad] Endereço:Division of Clinical Pharmacology & Toxicology, University Hospital Basel, Basel, Switzerland; Department of Biomedicine, University of Basel, Basel, Switzerland; Swiss Centre of Applied Human Toxicology, Basel, Switzerland.
[Ti] Título:Mechanisms of hepatocellular toxicity associated with new psychoactive synthetic cathinones.
[So] Source:Toxicology;387:57-66, 2017 Jul 15.
[Is] ISSN:1879-3185
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Synthetic cathinones are a new class of psychostimulant substances. Rarely, they can cause liver injury but associated mechanisms are not completely elucidated. In order to increase our knowledge about mechanisms of hepatotoxicity, we investigated the effect of five frequently used cathinones on two human cell lines. Bupropion was included as structurally related drug used therapeutically. In HepG2 cells, bupropion, MDPV, mephedrone and naphyrone depleted the cellular ATP content at lower concentrations (0.2-1mM) than cytotoxicity occurred (0.5-2mM), suggesting mitochondrial toxicity. In comparison, methedrone and methylone depleted the cellular ATP pool and induced cytotoxicity at similar concentrations (≥2mM). In HepaRG cells, cytotoxicity and ATP depletion could also be demonstrated, but cytochrome P450 induction did not increase the toxicity of the compounds investigated. The mitochondrial membrane potential was decreased in HepG2 cells by bupropion, MDPV and naphyrone, confirming mitochondrial toxicity. Bupropion, but not the other compounds, uncoupled oxidative phosphorylation. Bupropion, MDPV, mephedrone and naphyrone inhibited complex I and II of the electron transport chain, naphyrone also complex III. All four mitochondrial toxicants were associated with increased mitochondrial ROS and increased lactate production, which was accompanied by a decrease in the cellular total GSH pool for naphyrone and MDPV. In conclusion, bupropion, MDPV, mephedrone and naphyrone are mitochondrial toxicants impairing the function of the electron transport chain and depleting cellular ATP stores. Since liver injury is rare in users of these drugs, affected persons must have susceptibility factors rendering them more sensitive for these drugs.
[Mh] Termos MeSH primário: Alcaloides/toxicidade
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Hepatócitos/efeitos dos fármacos
Psicotrópicos/toxicidade
[Mh] Termos MeSH secundário: Trifosfato de Adenosina/metabolismo
Benzodioxóis/toxicidade
Bupropiona/toxicidade
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/patologia
Relação Dose-Resposta a Droga
Complexo de Proteínas da Cadeia de Transporte de Elétrons/metabolismo
Células Hep G2
Hepatócitos/metabolismo
Hepatócitos/patologia
Seres Humanos
Ácido Láctico/metabolismo
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Metanfetamina/análogos & derivados
Metanfetamina/toxicidade
Mitocôndrias Hepáticas/efeitos dos fármacos
Mitocôndrias Hepáticas/metabolismo
Mitocôndrias Hepáticas/patologia
Fosforilação Oxidativa/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Consumo de Oxigênio/efeitos dos fármacos
Pentanonas/toxicidade
Pirrolidinas/toxicidade
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (1-naphthalen-2-yl-2-pyrrolidin-1-ylpentan-1-one); 0 (3,4-methylenedioxypyrovalerone); 0 (Alkaloids); 0 (Benzodioxoles); 0 (Electron Transport Chain Complex Proteins); 0 (Pentanones); 0 (Psychotropic Drugs); 0 (Pyrrolidines); 0 (Reactive Oxygen Species); 01ZG3TPX31 (Bupropion); 33X04XA5AT (Lactic Acid); 44RAL3456C (Methamphetamine); 540EI4406J (cathinone); 8BA8T27317 (mephedrone); 8L70Q75FXE (Adenosine Triphosphate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170625
[St] Status:MEDLINE


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[PMID]:28430149
[Au] Autor:Yu L; Gan X; Zhou D; He F; Zeng S; Hu D
[Ad] Endereço:State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, Guizhou, China. yuji570@163.com.
[Ti] Título:Synthesis and Antiviral Activity of Novel 1,4-Pentadien-3-one Derivatives Containing a 1,3,4-Thiadiazole Moiety.
[So] Source:Molecules;22(4), 2017 Apr 21.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:1,4-Pentadien-3-one derivatives derived from curcumin possess excellent inhibitory activity against plant viruses. On the basis of this finding, a series of novel 1,4-pentadien-3-one derivatives containing a 1,3,4-thiadiazole moiety were designed and synthesized, and their structures confirmed by IR, ¹H-NMR, and C-NMR spectroscopy and elemental analysis. The antiviral activities of the title compounds were evaluated against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) in vivo. The assay results showed that most of compounds had remarkable antiviral activities against TMV and CMV, among which compounds , , , , , and exhibited good curative, protection, and inactivation activity against TMV. Compounds , , , , , and exhibited excellent protection activity against TMV, with EC values of 105.01, 254.77, 135.38, 297.40, 248.18, and 129.87 µg/mL, respectively, which were superior to that of ribavirin (457.25 µg/mL). In addition, preliminary SARs indicated that small electron-withdrawing groups on the aromatic ring were favorable for anti-TMV activity. This finding suggests that 1,4-pentadien-3-one derivatives containing a 1,3,4-thiadiazole moiety may be considered as potential lead structures for discovering new antiviral agents.
[Mh] Termos MeSH primário: Antivirais/síntese química
Antivirais/farmacologia
Cucumovirus/efeitos dos fármacos
Pentanonas/síntese química
Pentanonas/farmacologia
Tiadiazóis/síntese química
Tiadiazóis/farmacologia
Vírus do Mosaico do Tabaco/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antivirais/química
Relação Dose-Resposta a Droga
Desenho de Drogas
Espectroscopia de Ressonância Magnética
Testes de Sensibilidade Microbiana
Estrutura Molecular
Pentanonas/química
Ribavirina/farmacologia
Relação Estrutura-Atividade
Tiadiazóis/química
Vírus do Mosaico do Tabaco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Pentanones); 0 (Thiadiazoles); 14IAC3GH7G (1,3,4-thiadiazole); 49717AWG6K (Ribavirin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE


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[PMID]:28427995
[Au] Autor:Nelson KH; Hempel BJ; Clasen MM; Rice KC; Riley AL
[Ad] Endereço:Psychopharmacology Laboratory, Center for Behavioral Neuroscience, American University, 4400 Massachusetts Ave, NW, Washington, D.C. 20016, USA. Electronic address: kn9165a@student.american.edu.
[Ti] Título:Conditioned taste avoidance, conditioned place preference and hyperthermia induced by the second generation 'bath salt' α-pyrrolidinopentiophenone (α-PVP).
[So] Source:Pharmacol Biochem Behav;156:48-55, 2017 May.
[Is] ISSN:1873-5177
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: α-Pyrrolidinopentiophenone (α-PVP) has been reported to be rewarding in a variety of pre-clinical models. Given that a number of drugs of abuse have both rewarding and aversive effects, the balance of which influences addiction potential, the present study examined the aversive properties of α-PVP by assessing its ability to induce taste avoidance. This assessment was made in a combined taste avoidance/place conditioning design that also allowed an evaluation of the relationship between α-PVP's aversive and rewarding effects. METHODS: Male Sprague-Dawley rats were exposed to a novel saccharin solution, injected with one of four doses of α-PVP (0, 0.3, 1.0 and 3.0mg/kg) (IP) and placed on one side of a place conditioning apparatus. The next day, they were injected with vehicle, given access to water and placed on the other side. Following four conditioning cycles, saccharin avoidance and place preferences were then assessed. The effects of α-PVP on body temperature were also examined. RESULTS: α-PVP induced dose-dependent taste avoidance as well as significant increases in time spent on the drug-paired side (although this effect was not dependent on dose). α-PVP also induced dose- and time-dependent hyperthermia. CONCLUSIONS: α-PVP induced significant taste avoidance whose strength relative to the psychostimulants methylenedioxypyrovalerone (MDPV) and cocaine paralleled their relative binding to the dopamine transporter. Similar to other drugs of abuse, α-PVP has both aversive and rewarding effects. It will be important to assess how various experiential and subject variables impact these effects and their balance to predict abuse liability.
[Mh] Termos MeSH primário: Condicionamento Operante/efeitos dos fármacos
Febre/induzido quimicamente
Pentanonas/toxicidade
Pirrolidinas/toxicidade
Paladar
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Masculino
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (1-phenyl-2-(1-pyrrolidinyl)-1-pentanone); 0 (Pentanones); 0 (Pyrrolidines)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE


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[PMID]:28400150
[Au] Autor:Zhang G; Wu B; Zhang S
[Ad] Endereço:State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, China.
[Ti] Título:Effects of acetylacetone on the photoconversion of pharmaceuticals in natural and pure waters.
[So] Source:Environ Pollut;225:691-699, 2017 Jun.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Acetylacetone (AcAc) has proven to be a potent photo-activator in the degradation of color compounds. The effects of AcAc on the photochemical conversion of five colorless pharmaceuticals were for the first time investigated in both pure and natural waters with the UV/H O process as a reference. In most cases, AcAc played a similar role to H O . For example, AcAc accelerated the photodecomposition of carbamazepine, oxytetracycline, and tetracycline in pure water. Meanwhile, the toxicity of tetracyclines and carbamazepine were reduced to a similar extent to that in the UV/H O process. However, AcAc worked in a way different from that of H O . Based on the degradation kinetics, solvent kinetic isotope effect, and the inhibiting effect of O , the underlying mechanisms for the degradation of pharmaceuticals in the UV/AcAc process were believed mainly to be direct energy transfer from excited AcAc to pharmaceuticals rather than reactive oxygen species-mediated reactions. In natural waters, dissolved organic matter (DOM) played a crucial role in the photoconversion of pharmaceuticals. The role of H O became negligible due to the scavenging effects of DOM and inorganic ions. Interestingly, in natural waters, AcAc first accelerated the photodecomposition of pharmaceuticals and then led to a dramatic reduction with the depletion of dissolved oxygen. Considering the natural occurrence of diketones, the results here point out a possible pathway in the fate and transport of pharmaceuticals in aquatic ecosystems.
[Mh] Termos MeSH primário: Pentanonas/química
Processos Fotoquímicos/efeitos dos fármacos
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Carbamazepina
Peróxido de Hidrogênio/química
Cinética
Modelos Químicos
Oxigênio/química
Fotólise
Água/química
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pentanones); 0 (Water Pollutants, Chemical); 059QF0KO0R (Water); 33CM23913M (Carbamazepine); 46R950BP4J (acetylacetone); BBX060AN9V (Hydrogen Peroxide); S88TT14065 (Oxygen)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE


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[PMID]:28371583
[Au] Autor:Tomazin U; Groselj U; Pockaj M; Pozgan F; Stefane B; Svete J
[Ad] Endereço:Faculty of Chemistry and Chemical Technology, University of Ljubljana , Vecna pot 113, SI-1000 Ljubljana, Slovenia.
[Ti] Título:Combinatorial Synthesis of Acacen-Type Ligands and Their Coordination Compounds.
[So] Source:ACS Comb Sci;19(6):386-396, 2017 Jun 12.
[Is] ISSN:2156-8944
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A highly modular synthetic method for the preparation of acacen-type ligands and their coordination compounds was developed. A series of 46 acacen-type ligands were synthesized by a combinatorial acid-catalyzed transamination between six primary diamines and eight enaminones. The bis-enaminone products were used as tetradentate ligands for coordination of copper(II), nickel(II), cobalt(II), and palladium(II). Dependence of the preferred E- or Z-configuration of the enaminone ligand on the α-substituent of the enaminone moiety in solution was determined by NMR and confirmed by X-ray diffraction. The copper(II) complexes were tested for their suitability as catalysts in 3 + 2 cycloaddition of azomethine imine to methyl propiolate.
[Mh] Termos MeSH primário: Técnicas de Química Combinatória/métodos
Complexos de Coordenação/síntese química
Pentanonas/síntese química
[Mh] Termos MeSH secundário: Catálise
Cobalto/química
Complexos de Coordenação/química
Cobre/química
Cristalografia por Raios X
Diaminas/síntese química
Diaminas/química
Ligantes
Níquel/química
Paládio/química
Pentanonas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coordination Complexes); 0 (Diamines); 0 (Ligands); 0 (Pentanones); 3G0H8C9362 (Cobalt); 46R950BP4J (acetylacetone); 5TWQ1V240M (Palladium); 789U1901C5 (Copper); 7OV03QG267 (Nickel)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1021/acscombsci.7b00027


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[PMID]:28355044
[Au] Autor:Drug Enforcement Administration, Department of Justice
[Ti] Título:Schedules of Controlled Substances: Placement of 10 Synthetic Cathinones Into Schedule I. Final rule.
[So] Source:Fed Regist;82(39):12171-7, 2017 Mar 01.
[Is] ISSN:0097-6326
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:With the issuance of this final rule, the Drug Enforcement Administration places 10 synthetic cathinones: 4-methyl-N-ethylcathinone (4-MEC); 4-methyl-alpha-pyrrolidinopropiophenone (4-MePPP); alpha-pyrrolidinopentiophenone ([alpha]-PVP); 1-(1,3-benzodioxol-5-yl)-2-(methylamino)butan-1-one (butylone, bk-MBDB e); 2-(methylamino)-1-phenylpentan-1-one (pentedrone); 1-(1,3-benzodioxol-5-yl)-2-(methylamino)pentan-1-one (pentylone, bk-MBDP); 4-fluoro-N-methylcathinone (4-FMC, flephedrone); 3-fluoro-N-methylcathinone (3-FMC); 1-(naphthalen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one (naphyrone); alpha-pyrrolidinobutiophenone ([alpha]-PBP) and their optical, positional, and geometric isomers, salts and salts of isomers, whenever the existence of such salts, isomers, and salts of isomers is possible, into schedule I of the Controlled Substances Act. This scheduling action is pursuant to the Controlled Substances Act which requires that such actions be made on the record after opportunity for a hearing through formal rulemaking. This rule continues the imposition of the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances on persons who handle (manufacture, distribute, reverse distribute, import, export, engage in research, conduct instructional activities or chemical analysis, or possess), or propose to handle 4-MEC, 4-MePPP, [alpha]-PVP, butylone, pentedrone, pentylone, 4-FMC, 3- FMC, naphyrone, or [alpha]-PBP.
[Mh] Termos MeSH primário: Controle de Medicamentos e Entorpecentes/legislação & jurisprudência
Drogas Ilícitas/classificação
[Mh] Termos MeSH secundário: Alcaloides/classificação
Seres Humanos
Metilaminas/classificação
Pentanonas/classificação
Psicotrópicos/classificação
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Methylamines); 0 (Pentanones); 0 (Psychotropic Drugs); 0 (Street Drugs)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170419
[Lr] Data última revisão:
170419
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE


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[PMID]:28334805
[Au] Autor:Salomone A; Palamar JJ; Gerace E; Di Corcia D; Vincenti M
[Ad] Endereço:Centro Regionale Antidoping e di Tossicologia "A. Bertinaria", Orbassano, Turin, Italy.
[Ti] Título:Hair Testing for Drugs of Abuse and New Psychoactive Substances in a High-Risk Population.
[So] Source:J Anal Toxicol;41(5):376-381, 2017 Jun 01.
[Is] ISSN:1945-2403
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hundreds of new psychoactive substances (NPS) have emerged in the drug market over the last decade. Few drug surveys in the USA, however, ask about use of NPS, so prevalence and correlates of use are largely unknown. A large portion of NPS use is unintentional or unknown as NPS are common adulterants in drugs like ecstasy/Molly, and most NPS are rapidly eliminated from the body, limiting efficacy of urine, blood and saliva testing. We utilized a novel method of examining prevalence of NPS use in a high-risk population utilizing hair-testing. Hair samples from high-risk nightclub and dance music attendees were tested for 82 drugs and metabolites (including NPS) using ultra-high performance liquid chromatography-tandem mass spectrometry. Eighty samples collected from different parts of the body were analyzed, 57 of which detected positive for at least one substance-either a traditional or new drug. Among these, 26 samples tested positive for at least one NPS-the most common being butylone (25 samples). Other new drugs detected include methylone, methoxetamine, 5/6-APB, α-PVP and 4-FA. Hair analysis proved a powerful tool to gain objective biological drug-prevalence information, free from possible biases of unintentional or unknown intake and untruthful reporting of use. Such testing can be used actively or retrospectively to validate survey responses and inform research on consumption patterns, including intentional and unknown use, polydrug-use, occasional NPS intake and frequent or heavy use.
[Mh] Termos MeSH primário: Cabelo/química
Psicotrópicos/análise
Drogas Ilícitas/análise
Detecção do Abuso de Substâncias/métodos
[Mh] Termos MeSH secundário: Cicloexanonas/análise
Cicloexilaminas/análise
Seres Humanos
Metanfetamina/análogos & derivados
Metanfetamina/análise
N-Metil-3,4-Metilenodioxianfetamina/análise
Pentanonas/análise
Prevalência
Pirrolidinas/análise
Transtornos Relacionados ao Uso de Substâncias/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (1-phenyl-2-(1-pyrrolidinyl)-1-pentanone); 0 (Cyclohexanones); 0 (Cyclohexylamines); 0 (Pentanones); 0 (Psychotropic Drugs); 0 (Pyrrolidines); 0 (Street Drugs); 44RAL3456C (Methamphetamine); KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine); L4I4B1R01F (methylone); ZO5ZCE6E12 (2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1093/jat/bkx020



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