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[PMID]:28837732
[Au] Autor:Ranjith K; Sontam B; Sharma S; Joseph J; Chathoth KN; Sama KC; Murthy SI; Shivaji S
[Ad] Endereço:Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Kallam Anji Reddy campus, Hyderabad, India.
[Ti] Título:Candida Species From Eye Infections: Drug Susceptibility, Virulence Factors, and Molecular Characterization.
[So] Source:Invest Ophthalmol Vis Sci;58(10):4201-4209, 2017 Aug 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To determine the type of Candida species in ocular infections and to investigate the relationship of antifungal susceptibility profile to virulence factors. Methods: Fifty isolates of yeast-like fungi from patients with keratitis, endophthalmitis, and orbital cellulitis were identified by Vitek-2 compact system and DNA sequencing of ITS1-5.8S-ITS2 regions of the rRNA gene, followed by phylogenetic analysis for phenotypic and genotypic identification, respectively. Minimum inhibitory concentration of six antifungal drugs was determined by E test/microbroth dilution methods. Phenotypic and genotypic methods were used to determine the virulence factors. Results: Phylogenetic analysis showed the clustering of all isolates into eight distinct groups with a major cluster formed Candida parapsilosis (n = 21), which was the most common species by both Vitek 2 and DNA sequencing. Using χ2 test no significant difference was noted between the techniques except that Vitek 2 did not identify C. viswanathii, C. orthopsilosis, and two non-Candida genera. Of 43 tested Candida isolates high susceptibility to amphotericin B (39/43, 90.6%) and natamycin (43/43, 100%) was noted. While none of the isolates produced coagulase, all produced esterase and catalase. The potential to form biofilm was detected in 23/43 (53.4%) isolates. Distribution of virulence factors by heat map analysis showed difference in metabolic activity of biofilm producers from nonbiofilm producers. Conclusions: Identified by Vitek 2 and DNA sequencing methods C. parapsilosis was the most common species associated with eye infections. Irrespective of the virulence factors elaborated, the Candida isolates were susceptible to commonly used antifungal drugs such as amphotericin B and natamycin.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Candida
Candidíase/microbiologia
Infecções Oculares Fúngicas/microbiologia
Fatores de Virulência/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Anfotericina B/farmacologia
Biofilmes/crescimento & desenvolvimento
Candida/efeitos dos fármacos
Candida/genética
Candida/isolamento & purificação
Candida/metabolismo
Pré-Escolar
Endoftalmite/microbiologia
Feminino
Seres Humanos
Ceratite/microbiologia
Masculino
Testes de Sensibilidade Microbiana
Meia-Idade
Natamicina/farmacologia
Celulite Orbitária/microbiologia
RNA Fúngico/genética
RNA Ribossômico/genética
Análise de Sequência de DNA
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (RNA, Fungal); 0 (RNA, Ribosomal); 0 (Virulence Factors); 7XU7A7DROE (Amphotericin B); 8O0C852CPO (Natamycin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22003


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[PMID]:28817744
[Au] Autor:Prajna NV; Krishnan T; Rajaraman R; Patel S; Shah R; Srinivasan M; Das M; Ray KJ; Oldenburg CE; McLeod SD; Zegans ME; Acharya NR; Lietman TM; Rose-Nussbaumer J; Mycotic Ulcer Treatment Trial Group
[Ad] Endereço:Aravind Eye Care System, Madurai, Pondicherry, Tirunelveli and Coimbatore, India.
[Ti] Título:Predictors of Corneal Perforation or Need for Therapeutic Keratoplasty in Severe Fungal Keratitis: A Secondary Analysis of the Mycotic Ulcer Treatment Trial II.
[So] Source:JAMA Ophthalmol;135(9):987-991, 2017 Sep 01.
[Is] ISSN:2168-6173
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Identifying patients with infectious keratitis who are at risk of experiencing a poor outcome may be useful to allocate resources toward high-risk patients, particularly in resource-poor settings. Objective: To determine baseline patient and ulcer characteristics that predict a high risk of developing corneal perforation and/or the need to undergo therapeutic penetrating keratoplasty (TPK). Design, Setting, and Participants: This is a secondary analysis of Mycotic Ulcer Treatment Trial II, a multicenter, double-masked, placebo-controlled randomized clinical trial that enrolled 240 patients with smear-positive filamentous fungal corneal ulcers who enrolled between May 2010 and August 2015. Participants had a baseline visual acuity of 20/400 or worse and were randomized to receive oral voriconazole or a placebo (all participants received topical voriconazole, 1%). After 39 participants (16.3%) were enrolled, topical natamycin, 5%, was also added. Main Outcomes and Measures: The primary outcome of this secondary analysis was the rate of corneal perforation or the need to undergo TPK. Results: The mean (SD) age at enrollment was 49 (13) years, 104 participants (43.3%) were women, and all were of Southeast Asian descent. The presence of hypopyon at baseline indicated 2.28 times the odds of the patient developing corneal perforation and/or needing TPK (95% CI, 1.18-4.40; P = .01). Study participants whose infiltrate involved the posterior one-third had a 71.4% risk of developing corneal perforation and/or needing TPK. For each 1-mm increase in the geometric mean of the infiltrate, there was 1.37 (95% CI, 1.12-1.67; P = .002) increased odds of developing perforation and/or needing TPK. Other clinical features such as visual acuity, baseline culture positivity, type of filamentous fungal organism and duration of symptoms, and demographic characteristics, such as sex and occupation, were not significant predictors in the multivariable regression analysis. Conclusions and Relevance: These results suggest that risk stratification from baseline ulcer characteristics can identify those at highest risk for developing corneal perforation and/or needing TPK. Trial Registration: clinicaltrials.gov Identifier: NCT00996736.
[Mh] Termos MeSH primário: Antifúngicos/uso terapêutico
Perfuração da Córnea/diagnóstico
Úlcera da Córnea/diagnóstico
Infecções Oculares Fúngicas/diagnóstico
Ceratoplastia Penetrante
Micoses/diagnóstico
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Perfuração da Córnea/cirurgia
Úlcera da Córnea/tratamento farmacológico
Úlcera da Córnea/microbiologia
Método Duplo-Cego
Quimioterapia Combinada
Infecções Oculares Fúngicas/tratamento farmacológico
Infecções Oculares Fúngicas/microbiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Micoses/tratamento farmacológico
Micoses/microbiologia
Natamicina/uso terapêutico
Supuração/diagnóstico
Acuidade Visual/fisiologia
Voriconazol/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antifungal Agents); 8O0C852CPO (Natamycin); JFU09I87TR (Voriconazole)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1001/jamaophthalmol.2017.2914


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[PMID]:28054175
[Au] Autor:Qi Z; Zhou Y; Kang Q; Jiang C; Zheng J; Bai L
[Ad] Endereço:State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
[Ti] Título:Directed accumulation of less toxic pimaricin derivatives by improving the efficiency of a polyketide synthase dehydratase domain.
[So] Source:Appl Microbiol Biotechnol;101(6):2427-2436, 2017 Mar.
[Is] ISSN:1432-0614
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Pimaricin is an important polyene antifungal antibiotic that binds ergosterol and extracts it from fungal membranes. In previous work, two pimaricin derivatives (1 and 2) with improved pharmacological activities and another derivative (3) that showed no antifungal activity were produced by the mutant strain of Streptomyces chattanoogensis, in which the P450 monooxygenase gene scnG has been inactivated. Furthermore, inactivation of the DH12 dehydratase domain of the pimaricin polyketide synthases (PKSs) resulted in specific accumulation of the undesired metabolite 3, suggesting that improvement of the corresponding dehydratase activity may reduce or eliminate the accumulation of 3. Accordingly, the DH12-KR12 didomain within the pimaricin PKS was swapped with the fully active DH11-KR11 didomain. As predicted, the mutant was not able to produce 3 but accumulated 1 and 2 in high yields. Moreover, the effect of the flanking linker regions on domain swapping was evaluated. It was found that retention of the DH12-KR12 linker regions was more critical for the processivity of hybrid PKSs. Subsequently, high-yield production of 1 or 2 was obtained by overexpressing the scnD gene and its partner scnF and by disrupting the scnD gene, respectively. To our knowledge, this is the first report on the elimination of a polyketide undesired metabolite along with overproduction of desired product by improving the catalytic efficiency of a DH domain using a domain swapping technology.
[Mh] Termos MeSH primário: Antifúngicos/metabolismo
Proteínas de Bactérias/genética
Regulação Bacteriana da Expressão Gênica
Natamicina/biossíntese
Policetídeo Sintases/genética
Streptomyces/genética
[Mh] Termos MeSH secundário: Antifúngicos/química
Proteínas de Bactérias/metabolismo
Ergosterol/metabolismo
Mutação
Natamicina/química
Policetídeo Sintases/metabolismo
Domínios Proteicos
Engenharia de Proteínas
Streptomyces/metabolismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Bacterial Proteins); 79956-01-7 (Polyketide Synthases); 8O0C852CPO (Natamycin); Z30RAY509F (Ergosterol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170307
[Lr] Data última revisão:
170307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE
[do] DOI:10.1007/s00253-016-8074-7


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[PMID]:27889143
[Au] Autor:Tsiraki MI; Karam L; Abiad MG; Yehia HM; Savvaidis IN
[Ad] Endereço:Laboratory of Food Chemistry and Food Microbiology, Department of Chemistry, University of Ioannina, GR-45110, Ioannina, Greece.
[Ti] Título:Use of natural antimicrobials to improve the quality characteristics of fresh "Phyllo" - A dough-based wheat product - Shelf life assessment.
[So] Source:Food Microbiol;62:153-159, 2017 Apr.
[Is] ISSN:1095-9998
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study explores the effects of chitosan and natamycin on the quality of fresh "Phyllo" - a dough-based wheat product, by monitoring the microbiological, physicochemical and sensory parameters. Four different lots of phyllo samples stored under aerobic packaging conditions, in the absence or presence of the aforementioned antimicrobials, were prepared and stored at 4 °C. Microbiological data suggested that, the combination of chitosan and natamycin resulted in significant reductions (1-3 log cfu/g) of the microbial species examined (mesophilic total viable counts; TVC), yeasts/molds, psychrotrophic and lactic acid bacteria (LAB), Enterobacteriaceae and coliforms) by day 10. The pH values of treated phyllo samples were lower on final day 10, as compared to the untreated phyllo, and of the Hunter color parameters (L*, b* and a*) that were evaluated, mostly the combined treatment of chitosan and natamycin maintained the original lightness (L*) and color (yellowness) stability (b*) of phyllo product during the storage period. Sensory data, based on overall acceptability (mean values of appearance and odor) scores confirmed the superiority of combined treatment of chitosan and natamycin, resulting in almost a doubling of the shelf-life of fresh phyllo, while retaining excellent sensorial characteristics (appearance and odor) even on final storage day (10).
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Quitosana/farmacologia
Conservação de Alimentos/métodos
Armazenamento de Alimentos/normas
Natamicina/farmacologia
Triticum/microbiologia
[Mh] Termos MeSH secundário: Temperatura Baixa
Contagem de Colônia Microbiana
Culinária
Enterobacteriaceae/efeitos dos fármacos
Embalagem de Alimentos
Qualidade dos Alimentos
Armazenamento de Alimentos/métodos
Concentração de Íons de Hidrogênio
Lactobacillaceae/efeitos dos fármacos
Odorantes
Triticum/química
Leveduras/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 8O0C852CPO (Natamycin); 9012-76-4 (Chitosan)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161128
[St] Status:MEDLINE


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[PMID]:27874224
[Au] Autor:Wang TJ; Shan YM; Li H; Dou WW; Jiang XH; Mao XM; Liu SP; Guan WJ; Li YQ
[Ad] Endereço:Institute of Pharmaceutical Biotechnology, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.
[Ti] Título:Multiple transporters are involved in natamycin efflux in Streptomyces chattanoogensis L10.
[So] Source:Mol Microbiol;103(4):713-728, 2017 Feb.
[Is] ISSN:1365-2958
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Antibiotic-producing microorganisms have evolved several self-resistance mechanisms to prevent auto-toxicity. Overexpression of specific transporters to improve the efflux of toxic antibiotics has been found one of the most important and intrinsic resistance strategies used by many Streptomyces strains. In this work, two ATP-binding cassette (ABC) transporter-encoding genes located in the natamycin biosynthetic gene cluster, scnA and scnB, were identified as the primary exporter genes for natamycin efflux in Streptomyces chattanoogensis L10. Two other transporters located outside the cluster, a major facilitator superfamily transporter Mfs1 and an ABC transporter NepI/II were found to play a complementary role in natamycin efflux. ScnA/ScnB and Mfs1 also participate in exporting the immediate precursor of natamycin, 4,5-de-epoxynatamycin, which is more toxic to S. chattanoogensis L10 than natamycin. As the major complementary exporter for natamycin efflux, Mfs1 is up-regulated in response to intracellular accumulation of natamycin and 4,5-de-epoxynatamycin, suggesting a key role in the stress response for self-resistance. This article discusses a novel antibiotic-related efflux and response system in Streptomyces, as well as a self-resistance mechanism in antibiotic-producing strains.
[Mh] Termos MeSH primário: Transportadores de Cassetes de Ligação de ATP/genética
Antibacterianos/metabolismo
Transporte Biológico/genética
Farmacorresistência Bacteriana/genética
Proteínas de Membrana Transportadoras/genética
Natamicina/metabolismo
Streptomyces/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Farmacorresistência Bacteriana/fisiologia
Regulação Bacteriana da Expressão Gênica
Família Multigênica/genética
Streptomyces/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Membrane Transport Proteins); 8O0C852CPO (Natamycin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161123
[St] Status:MEDLINE
[do] DOI:10.1111/mmi.13583


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[PMID]:27766684
[Au] Autor:Tupaki-Sreepurna A; Al-Hatmi AM; Kindo AJ; Sundaram M; de Hoog GS
[Ad] Endereço:Department of Microbiology, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Chennai, India.
[Ti] Título:Multidrug-resistant Fusarium in keratitis: a clinico-mycological study of keratitis infections in Chennai, India.
[So] Source:Mycoses;60(4):230-233, 2017 Apr.
[Is] ISSN:1439-0507
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In this study, we aimed to present the first molecular epidemiological data from Chennai, India, analyse keratitis cases that have been monitored in a university hospital during 2 years, identify the responsible Fusarium species and determine antifungal susceptibilities. A total of 10 cases of keratitis were included in the study. Fusarium isolates were identified using the second largest subunit of the RNA polymerase gene (RPB2) and the translation elongation factor 1 alpha (TEF1). Antifungal susceptibility was tested by the broth microdilution method according to the Clinical and Laboratory Standards Institute (CLSI) methodology. The aetiological agents belonged to Fusarium solani species complex (FSSC) (n = 9) and Fusarium sambucinum species complex (FSAMSC) (n = 1), and the identified species were Fusarium keratoplasticum (n = 7), Fusarium falciforme (n = 2) and Fusarium sporotrichioides (n = 1). All strains showed multidrug resistance to azoles and caspofungin but exhibited lower minimum inhibitory concentration (MIC) to natamycin and amphotericin B. Fusarium keratoplasticum and Fusarium falciforme belonging to the Fusarium solani species complex were the major aetiological agents of Fusarium keratitis in this study. Early presentation and 5% topical natamycin was associated with better patient outcome. Preventative measures and monitoring of local epidemiological data play an important role in clinical practice.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Fusariose/epidemiologia
Fusarium/efeitos dos fármacos
Ceratite/epidemiologia
[Mh] Termos MeSH secundário: Administração Tópica
Adulto
Anfotericina B/farmacologia
Antifúngicos/uso terapêutico
Azóis/farmacologia
Farmacorresistência Fúngica Múltipla
Equinocandinas/farmacologia
Feminino
Fusariose/tratamento farmacológico
Fusariose/microbiologia
Fusarium/classificação
Fusarium/genética
Fusarium/isolamento & purificação
Genes Fúngicos/genética
Hospitais Universitários
Seres Humanos
Índia/epidemiologia
Ceratite/tratamento farmacológico
Ceratite/microbiologia
Lipopeptídeos/farmacologia
Masculino
Testes de Sensibilidade Microbiana
Meia-Idade
Natamicina/farmacologia
Natamicina/uso terapêutico
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Azoles); 0 (Echinocandins); 0 (Lipopeptides); 7XU7A7DROE (Amphotericin B); 8O0C852CPO (Natamycin); F0XDI6ZL63 (caspofungin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170324
[Lr] Data última revisão:
170324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161022
[St] Status:MEDLINE
[do] DOI:10.1111/myc.12578


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[PMID]:27744210
[Au] Autor:Ben-Fadhel Y; Saltaji S; Khlifi MA; Salmieri S; Dang Vu K; Lacroix M
[Ad] Endereço:Research Laboratories in Sciences Applied to Food, Canadian Irradiation Center, INRS -Institut Armand Frappier, Institute of Nutraceutical and Functionals Foods, 531 Boulevard des Prairies, Laval, QC H7V 1B7, Canada.
[Ti] Título:Active edible coating and γ-irradiation as cold combined treatments to assure the safety of broccoli florets (Brassica oleracea L.).
[So] Source:Int J Food Microbiol;241:30-38, 2017 Jan 16.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The antimicrobial activity of essential oils (EOs), organic acid (OA) salts and natamycin, a natural antifungal produced during fermentation by the bacterium Streptomyces natalensis, was assessed against four pathogens (Escherichia coli O157:H7, Listeria monocytogenes, Salmonella Typhimurium and Aspergillus niger). The Minimum Inhibitory Concentration (MIC) of each antimicrobial (AM) was assessed to determine their efficiency on tested microbial species in order to select the most efficient. Then, the interactions between different antimicrobial compounds showing the lowest MIC were determined by the checkerboard method. The most effective antimicrobial formulation showing synergistic or additive effects was then encapsulated in an alginate matrix to protect the antimicrobial efficiency during storage. The effectiveness of the formulation was then evaluated in situ using broccoli as a food model. A combined treatment of active coating and γ-irradiation (0.4 and 0.8kGy) was also done in order to evaluate the possible synergistic effect between treatments. The results of this study allowed the selection of 4 EOs, one OA salt and the natamycin as an antifungal agent exhibiting lower MIC values. The interactive antimicrobial effects between them showed that an antimicrobial formulation composed of 300ppm of lemongrass EO, 5000ppm of sodium diacetate and 80ppm of natamycin resulted in an additive effect against A. niger, E. coli and S. Typhimurium and showing synergistic effect against L. monocytogenes. Finally, in situ analyses showed a synergistic antimicrobial activity between active coating and γ-irradiation and allowed the extension of the shelf-life of ready-to-eat (RTE) broccoli during storage at 4°C.
[Mh] Termos MeSH primário: Antibacterianos/química
Brassica/microbiologia
Contaminação de Alimentos/prevenção & controle
Irradiação de Alimentos
Microbiologia de Alimentos
Raios gama
[Mh] Termos MeSH secundário: Acetatos/química
Aspergillus niger/efeitos dos fármacos
Cinnamomum zeylanicum/química
Contagem de Colônia Microbiana
Segurança de Produtos ao Consumidor
Cymbopogon/química
Escherichia coli O157/efeitos dos fármacos
Listeria monocytogenes/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Natamicina/química
Óleos Voláteis/farmacologia
Salmonella typhimurium/efeitos dos fármacos
Satureja/química
Timol/química
Thymus (Planta)/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Anti-Bacterial Agents); 0 (Oils, Volatile); 26WJH3CS0B (sodium diacetate); 3J50XA376E (Thymol); 8O0C852CPO (Natamycin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170917
[Lr] Data última revisão:
170917
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161017
[St] Status:MEDLINE


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[PMID]:27621301
[Au] Autor:Lee CY; Ho YJ; Sun CC; Lin HC; Hsiao CH; Ma DH; Lai CC; Chen HC
[Ad] Endereço:Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan.
[Ti] Título:Recurrent Fungal Keratitis and Blepharitis Caused by Aspergillus flavus.
[So] Source:Am J Trop Med Hyg;95(5):1216-1218, 2016 Nov 02.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aspergillus species produces a wide spectrum of fungal diseases like endophthalmitis and fungal keratitis ophthalmologically, but there has been no report about blepharitis caused by Aspergilus flavus to date. Herein, we report a 61-year-old ethnic Han Taiwanese male who had suffered from pain with burning and foreign body sensation after an insect bite on his left eye. Specimens from bilateral eyelids suggested infection of A. flavus, whereas corneal scraping showed the presence of Gram-negative bacteria. He was admitted for treatment of infectious keratitis with topical antibiotic and antifungal eye drops. Two weeks after discharge, recurrent blepharitis and keratitis of A. flavus was diagnosed microbiologically. Another treatment course of antifungal agent was resumed in the following 6 months, without further significant symptoms in the following 2 years. Collectively, it is possible for A. flavus to induce concurrent keratitis and blepharitis, and combined treatment of keratitis as well as blepharitis is advocated for as long as 6 months to ensure no recurrence.
[Mh] Termos MeSH primário: Aspergillus flavus/isolamento & purificação
Infecções Oculares Fúngicas/diagnóstico
Ceratite/diagnóstico
Ceratite/microbiologia
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Antifúngicos/uso terapêutico
Blefarite/diagnóstico
Blefarite/tratamento farmacológico
Blefarite/microbiologia
Infecções Oculares Fúngicas/tratamento farmacológico
Infecções Oculares Fúngicas/microbiologia
Seguimentos
Seres Humanos
Ceratite/tratamento farmacológico
Masculino
Meia-Idade
Natamicina/uso terapêutico
Taiwan
Tetraciclina/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 8O0C852CPO (Natamycin); F8VB5M810T (Tetracycline)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160914
[St] Status:MEDLINE


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[PMID]:27600042
[Au] Autor:Siddiqui R; Aqeel Y; Khan NA
[Ad] Endereço:Department of Biological Sciences, Faculty of Science and Technology, Sunway University, Malaysia.
[Ti] Título:The Development of Drugs against Acanthamoeba Infections.
[So] Source:Antimicrob Agents Chemother;60(11):6441-6450, 2016 Nov.
[Is] ISSN:1098-6596
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:For the past several decades, there has been little improvement in the morbidity and mortality associated with Acanthamoeba keratitis and Acanthamoeba encephalitis, respectively. The discovery of a plethora of antiacanthamoebic compounds has not yielded effective marketed chemotherapeutics. The rate of development of novel antiacanthamoebic chemotherapies of translational value and the lack of interest of the pharmaceutical industry in developing such chemotherapies have been disappointing. On the other hand, the market for contact lenses/contact lens disinfectants is a multi-billion-dollar industry and has been successful and profitable. A better understanding of drugs, their targets, and mechanisms of action will facilitate the development of more-effective chemotherapies. Here, we review the progress toward phenotypic drug discovery, emphasizing the shortcomings of useable therapies.
[Mh] Termos MeSH primário: Ceratite por Acanthamoeba/tratamento farmacológico
Acanthamoeba/efeitos dos fármacos
Antiprotozoários/farmacologia
Encefalite Infecciosa/tratamento farmacológico
[Mh] Termos MeSH secundário: Acanthamoeba/crescimento & desenvolvimento
Acanthamoeba/metabolismo
Ceratite por Acanthamoeba/parasitologia
Anfotericina B/farmacologia
Animais
Antiprotozoários/síntese química
Azóis/farmacologia
Biguanidas/farmacologia
Cefazolina/farmacologia
Clorexidina/farmacologia
Equinocandinas/farmacologia
Seres Humanos
Encefalite Infecciosa/parasitologia
Lipopeptídeos/farmacologia
Natamicina/farmacologia
Polimixina B/farmacologia
Tienamicinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Azoles); 0 (Biguanides); 0 (Echinocandins); 0 (Lipopeptides); 0 (Thienamycins); 1404-26-8 (Polymyxin B); 322U039GMF (polihexanide); 7XU7A7DROE (Amphotericin B); 8O0C852CPO (Natamycin); F0XDI6ZL63 (caspofungin); FV9J3JU8B1 (meropenem); IHS69L0Y4T (Cefazolin); R4KO0DY52L (Chlorhexidine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160908
[St] Status:MEDLINE
[do] DOI:10.1128/AAC.00686-16


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[PMID]:27589020
[Au] Autor:Streekstra H; Verkennis AE; Jacobs R; Dekker A; Stark J; Dijksterhuis J
[Ad] Endereço:DSM Biotechnology Center, PO Box 1, 2600 MA Delft, The Netherlands.
[Ti] Título:Fungal strains and the development of tolerance against natamycin.
[So] Source:Int J Food Microbiol;238:15-22, 2016 Dec 05.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Antimicrobial resistance is a relevant theme with respect to both antibacterial and antifungal compounds. In this study we address the possible development of tolerance against the antifungal food preservative natamycin. A selection of 20 fungal species, originating from a medical as well as a food product context, was subjected to increasing concentrations of natamycin for prolonged time, a procedure designated as "training". The range of Minimum Inhibitory Concentrations (M.I.C.) before (1.8-19.2µM) and after (1.8-19.8µM) training did not change significantly, but natamycin-exposure caused an increase of M.I.C. in 13 out of 20 tested strains. The average M.I.C. increased from 6.1 to 8.6µM and 4 strains showed a >2-fold increase of tolerance after training. One strain (of Aspergillus ochraceus) also showed increased tolerance to amphotericin B and nystatin. However, two Fusarium strains showed similar or even decreased tolerance for these other polyene antifungals. The work reported here shows that a continuous and prolonged increasing selection pressure induced natamycin tolerance in individual strains. This implies that such a selection pressure should be avoided in the technical application of natamycin to ensure its continued safe use as a food preservative.
[Mh] Termos MeSH primário: Farmacorresistência Fúngica
Fungos/efeitos dos fármacos
Natamicina/farmacologia
[Mh] Termos MeSH secundário: Anfotericina B/farmacologia
Antifúngicos/farmacologia
Conservantes de Alimentos/farmacologia
Fungos/fisiologia
Fusarium/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Nistatina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Food Preservatives); 1400-61-9 (Nystatin); 7XU7A7DROE (Amphotericin B); 8O0C852CPO (Natamycin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160903
[St] Status:MEDLINE



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