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[PMID]:29293328
[Au] Autor:Bhalsod GD; Chuang YH; Jeon S; Gui W; Li H; Ryser ET; Guber AK; Zhang W
[Ad] Endereço:Cook County Unit, University of Illinois Extension , Arlington Heights, Illinois 60004, United States.
[Ti] Título:Uptake and Accumulation of Pharmaceuticals in Overhead- and Surface-Irrigated Greenhouse Lettuce.
[So] Source:J Agric Food Chem;66(4):822-830, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Understanding the uptake and accumulation of pharmaceuticals in vegetables under typical irrigation practices is critical to risk assessment of crop irrigation with reclaimed water. This study investigated the pharmaceutical residues in greenhouse lettuce under overhead and soil-surface irrigations using pharmaceutical-contaminated water. Compared to soil-surface irrigation, overhead irrigation substantially increased the pharmaceutical residues in lettuce shoots. The increased residue levels persisted even after washing for trimethoprim, monensin sodium, and tylosin, indicating their strong sorption to the shoots. The postwashing concentrations in fresh shoots varied from 0.05 ± 0.04 µg/kg for sulfadiazine to 345 ± 139 µg/kg for carbamazepine. Root concentration factors ranged from 0.04 ± 0.14 for tylosin to 19.2 ± 15.7 for sulfamethoxazole. Translocation factors in surface-irrigated lettuce were low for sulfamethoxalzole, trimethoprim, monensin sodium, and tylosin (0.07-0.15), but high for caffeine (4.28 ± 3.01) and carbamazepine (8.15 ± 2.87). Carbamazepine was persistent in soil and hyperaccumulated in shoots.
[Mh] Termos MeSH primário: Irrigação Agrícola/métodos
Resíduos de Drogas/análise
Alface/metabolismo
Preparações Farmacêuticas/metabolismo
Poluentes Químicos da Água/metabolismo
[Mh] Termos MeSH secundário: Carbamazepina/análise
Contaminação de Alimentos
Alface/química
Monensin/análise
Preparações Farmacêuticas/análise
Folhas de Planta/química
Raízes de Plantas/química
Solo/química
Poluentes do Solo/análise
Poluentes do Solo/metabolismo
Sulfametoxazol/análise
Trimetoprima/análise
Tilosina/análise
Verduras
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pharmaceutical Preparations); 0 (Soil); 0 (Soil Pollutants); 0 (Water Pollutants, Chemical); 33CM23913M (Carbamazepine); 906O0YJ6ZP (Monensin); AN164J8Y0X (Trimethoprim); JE42381TNV (Sulfamethoxazole); YEF4JXN031 (Tylosin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04355


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[PMID]:28941460
[Au] Autor:Makarov GI; Sumbatyan NV; Bogdanov AA
[Ad] Endereço:Lomonosov Moscow State University, Faculty of Chemistry, Moscow, 119991, Russia.
[Ti] Título:Structural Insight into Interaction between C20 Phenylalanyl Derivative of Tylosin and Ribosomal Tunnel.
[So] Source:Biochemistry (Mosc);82(8):925-932, 2017 Aug.
[Is] ISSN:1608-3040
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Macrolides are clinically important antibiotics that inhibit protein biosynthesis on ribosomes by binding to ribosomal tunnel. Tylosin belongs to the group of 16-membered macrolides. It is a potent inhibitor of translation whose activity is largely due to reversible covalent binding of its aldehyde group with the base of A2062 in 23S ribosomal RNA. It is known that the conversion of the aldehyde group of tylosin to methyl or carbinol groups dramatically reduces its inhibitory activity. However, earlier we obtained several derivatives of tylosin having comparable activity in spite of the fact that the aldehyde group of tylosin in these compounds was substituted with an amino acid or a peptide residue. Details of the interaction of these compounds with the ribosome that underlies their high inhibitory activity were not known. In the present work, the structure of the complex of tylosin derivative containing in position 20 the residue of ethyl ester of 2-imino(oxy)acetylphenylalanine with the tunnel of the E. coli ribosome was identified by means of molecular dynamics simulations, which could explain high biological activity of this compound.
[Mh] Termos MeSH primário: RNA Ribossômico 23S/metabolismo
Tilosina/metabolismo
[Mh] Termos MeSH secundário: Sítios de Ligação
Escherichia coli/metabolismo
Ligações de Hidrogênio
Simulação de Dinâmica Molecular
Fenilalanina/química
Estrutura Terciária de Proteína
RNA Ribossômico 23S/química
Tilosina/análogos & derivados
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 23S); 47E5O17Y3R (Phenylalanine); YEF4JXN031 (Tylosin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170925
[St] Status:MEDLINE
[do] DOI:10.1134/S0006297917080077


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[PMID]:28615070
[Au] Autor:Berman J; Francoz D; Dubuc J; Buczinski S
[Ad] Endereço:Département des sciences cliniques, Faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, J2S 7C6, Canada.
[Ti] Título:A randomised clinical trial of a metaphylactic treatment with tildipirosin for bovine respiratory disease in veal calves.
[So] Source:BMC Vet Res;13(1):176, 2017 Jun 14.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Bovine respiratory disease (BRD) is a major problem in veal calf rearing units. The objective of this randomised clinical trial was to assess the effectiveness of tildipirosin as a metaphylactic treatment in veal calves on the number of BRD treatments, lung consolidation on thoracic ultrasonography (TUS) and average daily gain (ADG). A total of 209 veal calves from a pre-weaning fattening unit were randomly allocated to receive one of two treatments (tildipirosin 4 mg/kg, subcutaneously, n = 109; placebo 0.9% saline, subcutaneously, n = 100) at day 12 after entry in the pre-weaned unit. The calves were followed for a 70-day period. Occurrence of mortality and BRD treatments were recorded during the pre-weaning period. At days 1, 12 and 30, TUS and clinical scores were performed and ADG was measured during the first and second months of feeding. RESULTS: The use of a metaphylactic treatment of tildipirosin 12 days after arrival of the veal calves was not associated with the number of BRD treatments performed by the producer, ultrasonographic lung consolidation or weight gain (P < 0,05). In this cohort of calves, the proportion of calves treated for BRD by the producer was low at 14% (29/209). However, 13% (26/209) of calves included in the study already had ultrasonographic lung consolidation lesions 12 days after their arrival, which was before treatment time, and 27% (56/209) had lung consolidation at day 30. CONCLUSION: In this study population with a low BRD prevalence, we were not able to detect any benefit of tildipirosin as a metaphylactic treatment of BRD at day 12 after arrival based on BRD treatments, TUS, and ADG.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Doenças dos Bovinos/tratamento farmacológico
Doenças Respiratórias/veterinária
Tilosina/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Bovinos
Método Duplo-Cego
Feminino
Carne Vermelha
Doenças Respiratórias/tratamento farmacológico
Tilosina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (20,23-dipiperidinyl-mycaminosyl-tylonolide); 0 (Anti-Bacterial Agents); YEF4JXN031 (Tylosin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-017-1097-1


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[PMID]:28573221
[Au] Autor:Li B; Zhou XZ; Niu JR; Wei XJ; Li JY; Yang YJ; Liu XW; Cheng FS; Zhang JY
[Ad] Endereço:Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou, Gansu Province, China.
[Ti] Título:EFFICACY AND SAFETY OF BAN HUANG ORAL LIQUID FOR TREATING BOVINE RESPIRATORY DISEASES.
[So] Source:Afr J Tradit Complement Altern Med;14(2):47-59, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ban Huang oral liquid was developed as a veterinary compound preparation by the Lanzhou Institute of Husbandry and Pharmaceutical Sciences of the Chinese Academy of Agricultural Sciences (CAAS). The purpose of this study was to determine whether the oral liquid preparation of traditional Chinese medicine, Ban Huang, is safe and effective for treating respiratory diseases in cattle. MATERIALS AND METHODS: Acute oral toxicity experiments were conducted in Wistar rats and Kunming mice via oral administration. The minimum inhibitory concentration of the drug against with the double dilution method was 500 mg/mL, indicating good sensitivity. The results of laboratory pathogen testing, analysis of clinical symptoms, and analysis of pathological anatomy were combined to diagnose bovine respiratory diseases in 147 Simmental cattle caused by mixed infections of , bovine respiratory syncytial virus, bovine parainfluenza virus type 3, and . These cattle were randomly divided into three groups: drug treatment group 1 (treated via Tilmicosin injection), drug treatment group 2 (treated with Shuang Huang Lian oral liquid combined with Tilmicosin injection), and drug treatment group 3 (treated with Ban Huang oral liquid combined with Tilmicosin injection). Treatment effects were observed within 7 days. RESULTS: The results showed no toxicity and a maximum tolerated dose greater than 20 g/kg BW. For the 87 cattle in drug-treatment group, the cure rate was 90.80%, whereas the response rate was 94.25%. The cure rate of drug treatment group was increased by 14.13% in comparison with that of drug control group 1 and by 7.47% in comparison with that of drug control group 2 (both P < 0.05). CONCLUSION: This study demonstrates that Ban Huang oral liquid is a safe and effective treatment for bovine respiratory diseases, especially for mixed infection caused by , bacteria, and viruses.
[Mh] Termos MeSH primário: Doenças dos Bovinos/tratamento farmacológico
Medicamentos de Ervas Chinesas/uso terapêutico
Mycoplasma bovis/efeitos dos fármacos
Fitoterapia
Doenças Respiratórias/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Bovinos
Doenças dos Bovinos/microbiologia
Doenças dos Bovinos/virologia
Medicamentos de Ervas Chinesas/farmacologia
Mannheimia haemolytica
Camundongos
Testes de Sensibilidade Microbiana
Ratos Wistar
Vírus Sinciciais Respiratórios
Doenças Respiratórias/microbiologia
Doenças Respiratórias/veterinária
Doenças Respiratórias/virologia
Tilosina/análogos & derivados
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); XL4103X2E3 (tilmicosin); YEF4JXN031 (Tylosin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i2.6


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[PMID]:28559578
[Au] Autor:Sugawara A; Maruyama H; Shibusawa S; Matsui H; Hirose T; Tsutsui A; Froyman R; Ludwig C; Koebberling J; Hanaki H; Kleefeld G; Omura S; Sunazuka T
[Ad] Endereço:Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
[Ti] Título:5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity.
[So] Source:J Antibiot (Tokyo);70(8):878-887, 2017 Jul.
[Is] ISSN:0021-8820
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Tylosin is a 16-membered macrolide broad-spectrum antibiotic that has an important role in veterinary medicine, active against Gram-positive and a restricted range of Gram-negative bacteria. We synthesized 15 types of tylosin-related derivatives by chemical modification and evaluated them against mastitis pathogens. Among them, 20-deoxy-20-{N-methyl-N-[1-(3-quinolyl)-1H-1,2,3-triazol-4-yl]methylamino}-5-O-mycaminosyltylonolide 2f and 20-deoxy-20-{N-benzyl-N-[1-(3-quinolyl)-1H-1,2,3-triazol-4-yl]methylamino}-5-O-mycaminosyltylonolide 2k were found to not only expand their antibacterial impact to include Gram-negative bacteria, such as Escherichia coli and Klebsiella pneumoniae, but also to retain or increase antibacterial activity against Gram-positive bacteria, such as Staphylococcus aureus and Streptococcus uberis in comparison with the parent tylosin.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Leucomicinas/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/síntese química
Antibacterianos/química
Leucomicinas/síntese química
Leucomicinas/química
Tilosina/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Leucomycins); 61257-02-1 (mycaminosyltylonolide); YEF4JXN031 (Tylosin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1038/ja.2017.61


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[PMID]:28504455
[Au] Autor:Sato T; Higuchi H; Yokota SI; Tamura Y
[Ad] Endereço:Laboratory of Food Microbiology and Food Safety, Department of Health and Environmental Sciences, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyoudai-Midorimachi, Ebetsu, 069-8501, Japan.
[Ti] Título:Mycoplasma bovis isolates from dairy calves in Japan have less susceptibility than a reference strain to all approved macrolides associated with a point mutation (G748A) combined with multiple species-specific nucleotide alterations in 23S rRNA.
[So] Source:Microbiol Immunol;61(6):215-224, 2017 Jun.
[Is] ISSN:1348-0421
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Erythromycin, tylosin and tilmicosin are approved for use in cattle in Japan, the latter two being used to treat Mycoplasma bovis infection. In this study, 58 M. bovis isolates obtained from Japanese dairy calves all exhibited reduced susceptibility to these macrolides, this widespread reduced susceptibility being attributable to a few dominant lineages. All 58 isolates contained the G748A variant in both the rrl3 and rrl4 alleles of 23S rRNA, whereas a reference strain (PG45) did not. G748 localizes in the central loop of domain II (from C744 to A753) of 23S rRNA, which participates in binding to mycinose, a sugar residue present in both tylosin and tilmicosin. A number of in vitro-selected mutants derived from M. bovis PG45 showed reduced susceptibility to tylosin and tilmicosin and contained a nucleotide insertion within the central loop of domain II of rrl3 (U747-G748Ins_CU/GU or A743-U744Ins_UA), suggesting that mutations around G748 confer this reduced susceptibility phenotype. However, other Mycoplasma species containing G748A were susceptible to tylosin and tilmicosin. Sequence comparison with Escherichia coli revealed that M. bovis PG45 and isolates harbored five nucleotide alterations (U744C, G745A, U746C, A752C and A753G) in the central loop of domain II of 23S rRNA, whereas other Mycoplasma species lacked at least two of these five nucleotide alterations. It was therefore concluded that G748 mutations in combination with species-specific nucleotide alterations in the central loop of domain II of 23S rRNA are likely sufficient to reduce susceptibility of M. bovis to tylosin and tilmicosin.
[Mh] Termos MeSH primário: Laticínios/microbiologia
Macrolídeos/farmacologia
Mycoplasma bovis/efeitos dos fármacos
Mycoplasma bovis/genética
Mycoplasma bovis/isolamento & purificação
Mutação Puntual
RNA Ribossômico 23S/genética
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Proteínas de Bactérias/genética
Bovinos
DNA Bacteriano/genética
Farmacorresistência Bacteriana/genética
Eritromicina/farmacologia
Escherichia coli/genética
Genes Bacterianos/genética
Genótipo
Técnicas de Genotipagem
Japão
Testes de Sensibilidade Microbiana
Mutagênese Insercional
Infecções por Mycoplasma/veterinária
Especificidade da Espécie
Tilosina/análogos & derivados
Tilosina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (DNA, Bacterial); 0 (Macrolides); 0 (RNA, Ribosomal, 23S); 63937KV33D (Erythromycin); XL4103X2E3 (tilmicosin); YEF4JXN031 (Tylosin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE
[do] DOI:10.1111/1348-0421.12490


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[PMID]:28410479
[Au] Autor:Qin Y; Jatamunua F; Zhang J; Li Y; Han Y; Zou N; Shan J; Jiang Y; Pan C
[Ad] Endereço:Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, China.
[Ti] Título:Analysis of sulfonamides, tilmicosin and avermectins residues in typical animal matrices with multi-plug filtration cleanup by liquid chromatography-tandem mass spectrometry detection.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1053:27-33, 2017 May 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The frequent use of various veterinary drugs could lead to residue bioaccumulation in animal tissues, which could cause dietary risks to human health. In order to quickly analyze the residues, a liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed for detecting Sulfonamides, Tilmicosin and Avermectins (AVMs) residues in animal samples. For sample preparation, modified QuEChERS (quick, easy, cheap, effective, rugged and safe) and ultrasound-assisted extraction (UAE) methods were used. For sample cleanup, n-Hexane delipidation and multi-plug filtration cleanup (m-PFC) method based on primary-secondary amine (PSA) and octadecyl-silica (C18) were used, followed by LC-MS/MS analysis. It was validated on 7 animal matrices (bovine, caprine, swine meat and their kidneys, milk) at two fortified concentration levels of 5 and 100µg/kg. The recoveries ranged from 82 to 107% for all analytes with relative standard deviations (RSDs) less than 15%. Matrix-matched calibrations were performed with coefficients of determination above 0.998 for all analytes within concentration levels of 5-500µg/kg. The developed method was successfully used to analysis veterinary drugs of real animal samples from local markets.
[Mh] Termos MeSH primário: Anti-Infecciosos/análise
Ivermectina/análogos & derivados
Carne/análise
Leite/química
Sulfonamidas/análise
Tilosina/análogos & derivados
Drogas Veterinárias/análise
[Mh] Termos MeSH secundário: Animais
Bovinos
Cromatografia Líquida de Alta Pressão/métodos
Filtração/métodos
Análise de Alimentos/métodos
Contaminação de Alimentos
Cabras
Hexanos/química
Seres Humanos
Ivermectina/análise
Limite de Detecção
Sonicação/métodos
Suínos
Espectrometria de Massas em Tandem/métodos
Tilosina/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Hexanes); 0 (Sulfonamides); 0 (Veterinary Drugs); 2DDG612ED8 (n-hexane); 70288-86-7 (Ivermectin); 73989-17-0 (avermectin); XL4103X2E3 (tilmicosin); YEF4JXN031 (Tylosin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE


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[PMID]:28380607
[Au] Autor:Abell KM; Theurer ME; Larson RL; White BJ; Apley M
[Ti] Título:A mixed treatment comparison meta-analysis of metaphylaxis treatments for bovine respiratory disease in beef cattle.
[So] Source:J Anim Sci;95(2):626-635, 2017 Feb.
[Is] ISSN:1525-3163
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objective of this project was to evaluate the effects of antimicrobials approved for parenteral metaphylactic use in feeder and stocker calves on morbidity and mortality for bovine respiratory disease with the use of a mixed treatment comparison meta-analysis. An initial literature review was conducted in April 2016 through Pubmed, Agricola, and CAB (Commonwealth Agricultural Bureau) for randomized controlled trials for metaphylaxis antimicrobial administered parentally to incoming feedlot or stocker calves within 48 h of arrival. The final list of publications included 29 studies, with a total of 37 trials. There were 8 different metaphylactic antimicrobials. Final event outcomes were categorized into bovine respiratory disease (BRD) morbidity cumulative incidence d 1 to ≤ 60 of the feeding period, BRD morbidity cumulative incidence d 1 to closeout of the feeding period, BRD mortality cumulative incidence d 1 to closeout of the feeding period, and BRD retreatment cumulative incidence morbidity d 1 to closeout of the feeding period. Network meta-analysis combined direct and indirect evidence for all the event outcomes to determine mean odds ratio (OR) with 95% credibility intervals (CrIs) for all metaphylactic antimicrobial comparisons. The "upper tier" treatment arms for morbidity d 1 to ≤ 60 included tulathromycin, gamithromycin, and tilmicosin. For BRD mortality cumulative incidence d 1 to closeout and BRD retreatment morbidity d 1 to closeout, classifying the treatment arms into tiers was not possible due to overlapping 95% CrIs. The results of this project accurately identified differences between metaphylactic antimicrobials, and metaphylactic antimicrobial options appear to offer different outcomes on BRD morbidity and mortality odds in feedlot cattle.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Complexo Respiratório Bovino/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Complexo Respiratório Bovino/epidemiologia
Complexo Respiratório Bovino/virologia
Bovinos
Dissacarídeos/administração & dosagem
Compostos Heterocíclicos/administração & dosagem
Incidência
Macrolídeos/administração & dosagem
Tilosina/administração & dosagem
Tilosina/análogos & derivados
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Disaccharides); 0 (Heterocyclic Compounds); 0 (Macrolides); Q839I13422 (tulathromycin); XL4103X2E3 (tilmicosin); YEF4JXN031 (Tylosin); ZE856183S0 (gamithromycin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.2527/jas.2016.1062


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[PMID]:28260584
[Au] Autor:Nowakiewicz A; Ziólkowska G; Troscianczyk A; Zieba P; Gnat S
[Ad] Endereço:1​University of Life Sciences, Faculty of Veterinary Medicine, Institute of Biological Bases of Animal Diseases, Sub-Department of Veterinary Microbiology, Akademicka 12, 20-033 Lublin, Poland.
[Ti] Título:Determination of antimicrobial resistance of Enterococcus strains isolated from pigs and their genotypic characterization by method of amplification of DNA fragments surrounding rare restriction sites (ADSRRS fingerprinting).
[So] Source:J Med Microbiol;66(2):175-183, 2017 Mar.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: In this study, we analysed phenotypic resistance profiles and their reflection in the genomic profiles of Enterococcus spp. strains isolated from pigs raised on different farms. METHODOLOGY: Samples were collected from five pig farms (n=90 animals) and tested for Enterococcus. MICs of 12 antimicrobials were determined using the broth microdilution method, and epidemiological molecular analysis of strains belonging to selected species (faecalis, faecium and hirae) was performed using the ADSRRS-fingerprinting (amplification of DNA fragments surrounding rare restriction sites) method with a few modifications. RESULTS: The highest percentage of strains was resistant to tetracycline (73.4 %), erythromycin and tylosin (42.5 %) and rifampin (25.2 %), and a large number of strains exhibited high-level resistance to both kanamycin (25.2 %) and streptomycin (27.6 %). The strains of E. faecalis, E. faecium and E. hirae (n=184) revealed varied phenotypic resistance profiles, among which as many as seven met the criteria for multidrug resistance (30.4 % of strains tested). ADSRRS-fingerprinting analysis produced 17 genotypic profiles of individual strains which were correlated with their phenotypic resistance profiles. Only E. hirae strains susceptible to all of the chemotherapeutics tested had two different ADSRRS profiles. Moreover, eight animals were carriers of more than one genotype belonging to the same Enterococcus spp., mainly E. faecalis. CONCLUSION: Given the possibility of transmission to humans of the high-resistance/multidrug resistance enterococci and the significant role of pigs as food animals in this process, it is necessary to introduce a multilevel control strategy by carrying out research on the resistance and molecular characteristics of indicator bacterial strains isolated from animals on individual farms.
[Mh] Termos MeSH primário: DNA Bacteriano/isolamento & purificação
Farmacorresistência Bacteriana Múltipla
Técnicas de Genotipagem
Estreptomicina
Suínos/microbiologia
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Impressões Digitais de DNA
DNA Bacteriano/genética
Enterococcus faecalis/efeitos dos fármacos
Enterococcus faecalis/isolamento & purificação
Enterococcus faecium/efeitos dos fármacos
Enterococcus faecium/isolamento & purificação
Enterococcus hirae/efeitos dos fármacos
Enterococcus hirae/isolamento & purificação
Eritromicina/farmacologia
Canamicina/farmacologia
Testes de Sensibilidade Microbiana
Técnicas de Amplificação de Ácido Nucleico
Rifampina/farmacologia
Estreptomicina/farmacologia
Tetraciclina/farmacologia
Resistência a Tetraciclina
Tilosina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (DNA, Bacterial); 59-01-8 (Kanamycin); 63937KV33D (Erythromycin); F8VB5M810T (Tetracycline); VJT6J7R4TR (Rifampin); Y45QSO73OB (Streptomycin); YEF4JXN031 (Tylosin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000400


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[PMID]:28128649
[Au] Autor:Hume ME; Donskey CJ
[Ad] Endereço:1 Food and Feed Safety Research Unit, Southern Plains Agricultural Research Center , Agricultural Research Service, U.S. Department of Agriculture, College Station, Texas.
[Ti] Título:Effect of Vancomycin, Tylosin, and Chlortetracycline on Vancomycin-Resistant Enterococcus faecium Colonization of Broiler Chickens During Grow-Out.
[So] Source:Foodborne Pathog Dis;14(4):231-237, 2017 Apr.
[Is] ISSN:1556-7125
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Broiler chickens may serve as reservoirs for human colonization by vancomycin-resistant Enterococcus (VRE). We examined the effects of vancomycin and two commonly used antimicrobial feed additives on VRE colonization in broiler chickens during grow-out. Chicks received unsupplemented feed or feed containing vancomycin, chlortetracycline, or tylosin from day of hatch to grow-out at 6 weeks. At 3 days of age, chicks received by crop gavage 10 colony-forming units (CFUs) of a human or poultry VRE isolate. Cecal contents were monitored weekly for VRE, short-chain fatty acids (SCFAs), and bacterial denaturing gradient gel electrophoresis (DGGE) profile methods. Vancomycin promoted persistent and high-level colonization with human- and poultry-derived VRE to grow-out in comparison with controls, while treatment with chlortetracycline and tylosin did not. Colonization by the poultry isolate in control, chlortetracycline, and tylosin groups persisted throughout the grow-out period with low concentrations present at 6 weeks, whereas the human isolate decreased to an undetectable level by week 6. Vancomycin resulted in significant reductions in cecal acetic acid and butyric acid in comparison with controls, but chlortetracycline and tylosin did not. DGGE profiles contained two main clusters with all vancomycin profiles in a smaller cluster and all other profiles in a larger cluster. These results demonstrate that vancomycin, but not chlortetracycline or tylosin, disrupted the indigenous microbiota and SCFA patterns of broiler chickens and promoted colonization by VRE.
[Mh] Termos MeSH primário: Galinhas/microbiologia
Clortetraciclina/farmacologia
Farmacorresistência Bacteriana Múltipla
Enterococcus faecium/efeitos dos fármacos
Tilosina/farmacologia
Vancomicina/farmacologia
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Ceco/microbiologia
Contagem de Colônia Microbiana
Eletroforese em Gel de Gradiente Desnaturante
Enterococcus faecium/isolamento & purificação
Ácidos Graxos Voláteis/análise
Fezes/microbiologia
Contaminação de Alimentos/análise
Microbiologia de Alimentos
Aves Domésticas/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Fatty Acids, Volatile); 6Q205EH1VU (Vancomycin); WCK1KIQ23Q (Chlortetracycline); YEF4JXN031 (Tylosin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE
[do] DOI:10.1089/fpd.2016.2217



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