Base de dados : MEDLINE
Pesquisa : D02.540.576.500.968 [Categoria DeCS]
Referências encontradas : 227 [refinar]
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  1 / 227 MEDLINE  
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[PMID]:25773336
[Au] Autor:Szwarc K; Szczeblewski P; Sowinski P; Borowski E; Pawlak J
[Ad] Endereço:Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Narutowicza St. 11/12, 80233, Gdansk, Poland.
[Ti] Título:The structure, including stereochemistry, of levorin A1.
[So] Source:Magn Reson Chem;53(6):479-84, 2015 Jun.
[Is] ISSN:1097-458X
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Antibacterianos/química
Candicidina/química
[Mh] Termos MeSH secundário: Espectroscopia de Ressonância Magnética/normas
Estrutura Molecular
Padrões de Referência
Estereoisomerismo
[Pt] Tipo de publicação:LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 1403-17-4 (Candicidin)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150522
[Lr] Data última revisão:
150522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150317
[St] Status:MEDLINE
[do] DOI:10.1002/mrc.4229


  2 / 227 MEDLINE  
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[PMID]:25712395
[Au] Autor:Szwarc K; Szczeblewski P; Sowinski P; Borowski E; Pawlak J
[Ad] Endereço:Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gdansk, Poland.
[Ti] Título:The stereostructure of candicidin D.
[So] Source:J Antibiot (Tokyo);68(8):504-10, 2015 Aug.
[Is] ISSN:0021-8820
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The candicidin D stereostructure was established based on NMR studies including DQF-COSY, ROESY, HSQC and HMBC experiments. The relative configurations of the candicidin D stereogenic centers were assigned as the following: 9R*, 11S*, 13S*, 15R*, 17S*, 18R*, 19S*, 21R*, 36S*, 37R*, 38S*, 40S* and 41S*. The geometry of the heptaene chromophore was defined as 22E, 24E, 26Z, 28Z, 30E, 32E and 34E.
[Mh] Termos MeSH primário: Candicidina/química
Estrutura Molecular
[Mh] Termos MeSH secundário: Seres Humanos
Espectroscopia de Ressonância Magnética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
1403-17-4 (Candicidin)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150226
[St] Status:MEDLINE
[do] DOI:10.1038/ja.2015.17


  3 / 227 MEDLINE  
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[PMID]:25575546
[Au] Autor:Zhang P; Zhao Z; Li H; Chen XL; Deng Z; Bai L; Pang X
[Ad] Endereço:State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, PR China.
[Ti] Título:Production of the antibiotic FR-008/candicidin in Streptomyces sp. FR-008 is co-regulated by two regulators, FscRI and FscRIV, from different transcription factor families.
[So] Source:Microbiology;161(Pt 3):539-52, 2015 Mar.
[Is] ISSN:1465-2080
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In Streptomyces sp. FR-008, the biosynthetic gene cluster of the polyene antibiotic FR-008, also known as candicidin, consists of 21 genes, including four regulatory genes, fscRI-fscRIV. Our bioinformatics analyses indicate that FscRI has an N-terminal PAS domain, whereas the other three regulators have N-terminal AAA domains and are members of the LAL (large ATP-binding regulators of the LuxR type) family. Deletion of fscRI abolished the production of FR-008, with production restored in the complemented strain, supporting a critical role for FscRI in FR-008 biosynthesis. Consistent with these findings, transcription of genes involved in the biosynthesis and efflux of FR-008 was greatly downregulated in a ΔfscRI mutant. Interestingly, the regulatory gene fscRIV was also downregulated in the ΔfscRI mutant. Production of FR-008 was reduced, but not abrogated, in an fscRIV deletion mutant, and although structural genes were downregulated in ΔfscRIV, the changes were much less dramatic than in ΔfscRI, suggesting a stronger regulatory role for FscRI. Remarkably, transcription of fscRI was also decreased in ΔfscRIV. Expression of fscRI restored antibiotic production in a ΔfscRIV mutant, but not vice versa. Putative binding sequences for FscRI were identified upstream of fscRIV and the three structural genes fscA, fscB and fscD, which encode large modular polyketide synthases. Our findings suggest that fscRI and fscRIV are interregulatory, whereas expression of fscRII and fscRIII appears to be independent of fscRI and fscRIV. This study demonstrates that the regulation of polyene antibiotic synthesis can involve mutually regulated transcriptional activators that belong to different families.
[Mh] Termos MeSH primário: Antibacterianos/biossíntese
Proteínas de Bactérias/metabolismo
Candicidina/biossíntese
Regulação Bacteriana da Expressão Gênica
Streptomyces/metabolismo
Fatores de Transcrição/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Proteínas de Bactérias/química
Proteínas de Bactérias/genética
Genes Reguladores
Dados de Sequência Molecular
Alinhamento de Sequência
Streptomyces/química
Streptomyces/genética
Fatores de Transcrição/química
Fatores de Transcrição/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (Transcription Factors); 1403-17-4 (Candicidin)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:150226
[Lr] Data última revisão:
150226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150111
[St] Status:MEDLINE
[do] DOI:10.1099/mic.0.000033


  4 / 227 MEDLINE  
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[PMID]:23324745
[Au] Autor:Lei X; Kong L; Zhang C; Liu Q; Yao F; Zhang W; Deng Z; You D
[Ad] Endereço:State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China.
[Ti] Título:In vivo investigation of the substrate recognition capability and activity affecting amino acid residues of glycosyltransferase FscMI in the biosynthesis of candicidin.
[So] Source:Mol Biosyst;9(3):422-30, 2013 Mar.
[Is] ISSN:1742-2051
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Alteration of sugar moieties of natural products often leads to novel antibiotics with different chemical and physical properties. fscMI is a putative glycosyltransferase (GT) in a gene cluster for the production of candicidin, a polyene macrolide antibiotic, produced by Streptomyces sp. FR-008. In this report, we established an in vivo biochemical detection system by inactivating fscMI and the DH11 domain of polyketide synthase (PKS) through double homologous recombination to unveil the interaction between polyene GTs and their substrates. We found that homologous GT genes including amphDI, nysDI and pimK can catalyze the conversion of candicidin aglycone into candicidin/FR-008-III in fscMI mutant, suggesting that homologous polyene GTs show some tolerance toward aglycones and that it is possible to create new polyene analogues with altered aglycones through genetic engineering. Inactivation of the DH11 domain of PKS led to novel polyene derivatives with mycosamine added to the altered polyketide backbones, further confirming the loose substrate specificity of polyene GTs. Furthermore, mutation of Ser346, Ser361, His362 or Cys387 of FscMI by site-directed mutagenesis significantly reduced its catalytic activity. Further analysis suggested that Ser361 and Cys387 are likely the critical donor interacting residues that could affect the activity of GT FscMI. To our knowledge, this is the first report of the critical residues in a polyene GT.
[Mh] Termos MeSH primário: Proteínas de Bactérias/química
Candicidina/biossíntese
Glicosiltransferases/química
Streptomyces/enzimologia
[Mh] Termos MeSH secundário: Motivos de Aminoácidos
Substituição de Aminoácidos
Proteínas de Bactérias/genética
Domínio Catalítico
Fermentação
Técnicas de Inativação de Genes
Glicosilação
Glicosiltransferases/genética
Família Multigênica
Mutagênese Sítio-Dirigida
Ligação Proteica
Streptomyces/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bacterial Proteins); 1403-17-4 (Candicidin); EC 2.4.- (Glycosyltransferases)
[Em] Mês de entrada:1307
[Cu] Atualização por classe:130205
[Lr] Data última revisão:
130205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130118
[St] Status:MEDLINE
[do] DOI:10.1039/c2mb25464f


  5 / 227 MEDLINE  
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[PMID]:23457795
[Au] Autor:Lei X; Kong L; Zhang C; You D; Deng Z
[Ad] Endereço:State Key Laboratory of Microbial Metabolism and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, China. myown625@sjtu.edu.cn
[Ti] Título:[Function of transporter genes fscTI and fscTII in the biosynthetic cluster of candicidin/FR-008].
[So] Source:Wei Sheng Wu Xue Bao;52(12):1458-66, 2012 Dec 04.
[Is] ISSN:0001-6209
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:UNLABELLED: OBJECTIVE To investigate function of transporter genes fscTI and fscTII in the biosynthetic gene cluster of candicidin/FR-008. METHODS: We constructed a plasmid pJTU4137 for disruption of transporter genes fscTI and fscTII by conjugation and homologous recombinant. The transporter genes were also PCR amplified and cloned into the high-copy plasmid pJTU1278 for overexpression in strain ZYJ-6 derived from Streptomyces sp. FR-008. RESULTS: The disruption mutant LX10 was unable to produce candicidin and its analogues. Overexpression of FscTI and FscTII in ZYJ-6 caused a 1.5-fold increase in FR-008-III production compared with the control. CONCLUSION: We confirmed that fscTI and fscTII are function as ATP dependent ATP binding cassetle (ABC) transporters in the biosynthetic gene cluster of FR-008. Furthermore, a positive example was provided for improving antibiotic production in other polyene producing strains based on the results that overexpression of fscTI and fscTI increased candicidin production.
[Mh] Termos MeSH primário: Transportadores de Cassetes de Ligação de ATP/metabolismo
Proteínas de Bactérias/metabolismo
Candicidina/biossíntese
Família Multigênica
Streptomyces/metabolismo
[Mh] Termos MeSH secundário: Transportadores de Cassetes de Ligação de ATP/genética
Trifosfato de Adenosina/metabolismo
Proteínas de Bactérias/genética
Streptomyces/genética
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bacterial Proteins); 1403-17-4 (Candicidin); 8L70Q75FXE (Adenosine Triphosphate)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130306
[St] Status:MEDLINE


  6 / 227 MEDLINE  
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[PMID]:23084933
[Au] Autor:Seipke RF; Grüschow S; Goss RJ; Hutchings MI
[Ad] Endereço:School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, United Kingdom.
[Ti] Título:Isolating antifungals from fungus-growing ant symbionts using a genome-guided chemistry approach.
[So] Source:Methods Enzymol;517:47-70, 2012.
[Is] ISSN:1557-7988
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We describe methods used to isolate and identify antifungal compounds from actinomycete strains associated with the leaf-cutter ant Acromyrmex octospinosus. These ants use antibiotics produced by symbiotic actinomycete bacteria to protect themselves and their fungal cultivar against bacterial and fungal infections. The fungal cultivar serves as the sole food source for the ant colony, which can number up to tens of thousands of individuals. We describe how we isolate bacteria from leaf-cutter ants collected in Trinidad and analyze the antifungal compounds made by two of these strains (Pseudonocardia and Streptomyces spp.), using a combination of genome analysis, mutagenesis, and chemical isolation. These methods should be generalizable to a wide variety of insect-symbiont situations. Although more time consuming than traditional activity-guided fractionation methods, this approach provides a powerful technique for unlocking the complete biosynthetic potential of individual strains and for avoiding the problems of rediscovery of known compounds. We describe the discovery of a novel nystatin compound, named nystatin P1, and identification of the biosynthetic pathway for antimycins, compounds that were first described more than 60 years ago. We also report that disruption of two known antifungal pathways in a single Streptomyces strain has revealed a third, and likely novel, antifungal plus four more pathways with unknown products. This validates our approach, which clearly has the potential to identify numerous new compounds, even from well-characterized actinomycete strains.
[Mh] Termos MeSH primário: Antifúngicos/isolamento & purificação
Formigas/microbiologia
Bioensaio/métodos
Genoma Bacteriano
Genômica/métodos
Streptomyces/isolamento & purificação
Simbiose
[Mh] Termos MeSH secundário: Animais
Antifúngicos/química
Antifúngicos/farmacologia
Antimicina A/análogos & derivados
Antimicina A/biossíntese
Antimicina A/química
Antimicina A/isolamento & purificação
Candicidina/biossíntese
Candicidina/química
Candicidina/isolamento & purificação
Candida albicans/efeitos dos fármacos
Cromatografia Líquida/métodos
Clonagem Molecular
Testes de Sensibilidade Microbiana
Família Multigênica
Nistatina/biossíntese
Nistatina/química
Nistatina/isolamento & purificação
Streptomyces/química
Streptomyces/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antifungal Agents); 11118-72-2 (antimycin); 1400-61-9 (Nystatin); 1403-17-4 (Candicidin); 642-15-9 (Antimycin A)
[Em] Mês de entrada:1303
[Cu] Atualização por classe:121022
[Lr] Data última revisão:
121022
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121023
[St] Status:MEDLINE


  7 / 227 MEDLINE  
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[PMID]:21857911
[Au] Autor:Seipke RF; Barke J; Brearley C; Hill L; Yu DW; Goss RJ; Hutchings MI
[Ad] Endereço:School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, United Kingdom. r.seipke@uea.ac.uk
[Ti] Título:A single Streptomyces symbiont makes multiple antifungals to support the fungus farming ant Acromyrmex octospinosus.
[So] Source:PLoS One;6(8):e22028, 2011.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Attine ants are dependent on a cultivated fungus for food and use antibiotics produced by symbiotic Actinobacteria as weedkillers in their fungus gardens. Actinobacterial species belonging to the genera Pseudonocardia, Streptomyces and Amycolatopsis have been isolated from attine ant nests and shown to confer protection against a range of microfungal weeds. In previous work on the higher attine Acromyrmex octospinosus we isolated a Streptomyces strain that produces candicidin, consistent with another report that attine ants use Streptomyces-produced candicidin in their fungiculture. Here we report the genome analysis of this Streptomyces strain and identify multiple antibiotic biosynthetic pathways. We demonstrate, using gene disruptions and mass spectrometry, that this single strain has the capacity to make candicidin and multiple antimycin compounds. Although antimycins have been known for >60 years we report the sequence of the biosynthetic gene cluster for the first time. Crucially, disrupting the candicidin and antimycin gene clusters in the same strain had no effect on bioactivity against a co-evolved nest pathogen called Escovopsis that has been identified in ∼30% of attine ant nests. Since the Streptomyces strain has strong bioactivity against Escovopsis we conclude that it must make additional antifungal(s) to inhibit Escovopsis. However, candicidin and antimycins likely offer protection against other microfungal weeds that infect the attine fungal gardens. Thus, we propose that the selection of this biosynthetically prolific strain from the natural environment provides A. octospinosus with broad spectrum activity against Escovopsis and other microfungal weeds.
[Mh] Termos MeSH primário: Antibacterianos/biossíntese
Formigas/crescimento & desenvolvimento
Streptomyces/metabolismo
Simbiose
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Antifúngicos/metabolismo
Antifúngicos/farmacologia
Antimicina A/biossíntese
Antimicina A/farmacologia
Formigas/microbiologia
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Candicidina/biossíntese
Candicidina/farmacologia
Fungos/efeitos dos fármacos
Fungos/crescimento & desenvolvimento
Interações Hospedeiro-Patógeno
Hypocreales/efeitos dos fármacos
Hypocreales/crescimento & desenvolvimento
Espectrometria de Massas/métodos
Mutação
Streptomyces/genética
Streptomyces/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Bacterial Proteins); 1403-17-4 (Candicidin); 642-15-9 (Antimycin A)
[Em] Mês de entrada:1202
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110823
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0022028


  8 / 227 MEDLINE  
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[PMID]:21033581
[Au] Autor:Stanchev VS; Kozhuharova LY; Zhekova BY; Gochev VK
[Ad] Endereço:Department of Automatics, Information and Control Systems, University of Food Technologies, Plovdiv, Bulgaria. vsstanchev@abv.bg
[Ti] Título:Optimisation of synthetic medium composition for levorin biosynthesis by Streptomyces levoris 99/23 and investigation of its accumulation dynamics using mathematical modelling methods.
[So] Source:Pol J Microbiol;59(3):179-83, 2010.
[Is] ISSN:1733-1331
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:The composition of a synthetic culture medium for levorin biosynthesis by Streptomyces levoris 99/23 was optimised using mathematical modelling methods. The optimal concentrations of the medium components were established by means of an optimum composition design at three factor variation levels. An adequate regression model was obtained. Levorin biosynthesis by Streptomyces levoris 99/23 in the optimised synthetic medium was over 38% higher than in the initial medium. The antibiotic biosynthesis dynamics in the optimised culture medium was studied by means of a non-linear differential equation system. The resultant model was valid.
[Mh] Termos MeSH primário: Candicidina/biossíntese
Meios de Cultura/química
Streptomyces/classificação
Streptomyces/metabolismo
[Mh] Termos MeSH secundário: Biomarcadores
Meios de Cultura/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Culture Media); 1403-17-4 (Candicidin)
[Em] Mês de entrada:1012
[Cu] Atualização por classe:161021
[Lr] Data última revisão:
161021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101102
[St] Status:MEDLINE


  9 / 227 MEDLINE  
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[PMID]:20927795
[Au] Autor:Lee SJ; Anderson TM; Burke MD
[Ad] Endereço:Howard Hughes Medical Institute, Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Ave, Urbana, IL 61801, USA.
[Ti] Título:A simple and general platform for generating stereochemically complex polyene frameworks by iterative cross-coupling.
[So] Source:Angew Chem Int Ed Engl;49(47):8860-3, 2010 Nov 15.
[Is] ISSN:1521-3773
[Cp] País de publicação:Germany
[La] Idioma:eng
[Mh] Termos MeSH primário: Polienos/química
[Mh] Termos MeSH secundário: Ácidos Borônicos/química
Candicidina/análogos & derivados
Candicidina/química
Halogênios/química
Iminoácidos/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Boronic Acids); 0 (Halogens); 0 (Imino Acids); 0 (N-methyliminodiacetic acid); 0 (Polyenes); 1403-17-4 (Candicidin); 66120-71-6 (vacidin A)
[Em] Mês de entrada:1103
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101008
[St] Status:MEDLINE
[do] DOI:10.1002/anie.201004911


  10 / 227 MEDLINE  
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[PMID]:20796277
[Au] Autor:Barke J; Seipke RF; Grüschow S; Heavens D; Drou N; Bibb MJ; Goss RJ; Yu DW; Hutchings MI
[Ad] Endereço:School of Biological Sciences, University of East Anglia, Norwich, Norwich Research Park, UK.
[Ti] Título:A mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosus.
[So] Source:BMC Biol;8:109, 2010 Aug 26.
[Is] ISSN:1741-7007
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Attine ants live in an intensely studied tripartite mutualism with the fungus Leucoagaricus gongylophorus, which provides food to the ants, and with antibiotic-producing actinomycete bacteria. One hypothesis suggests that bacteria from the genus Pseudonocardia are the sole, co-evolved mutualists of attine ants and are transmitted vertically by the queens. A recent study identified a Pseudonocardia-produced antifungal, named dentigerumycin, associated with the lower attine Apterostigma dentigerum consistent with the idea that co-evolved Pseudonocardia make novel antibiotics. An alternative possibility is that attine ants sample actinomycete bacteria from the soil, selecting and maintaining those species that make useful antibiotics. Consistent with this idea, a Streptomyces species associated with the higher attine Acromyrmex octospinosus was recently shown to produce the well-known antifungal candicidin. Candicidin production is widespread in environmental isolates of Streptomyces, so this could either be an environmental contaminant or evidence of recruitment of useful actinomycetes from the environment. It should be noted that the two possibilities for actinomycete acquisition are not necessarily mutually exclusive. RESULTS: In order to test these possibilities we isolated bacteria from a geographically distinct population of A. octospinosus and identified a candicidin-producing Streptomyces species, which suggests that they are common mutualists of attine ants, most probably recruited from the environment. We also identified a Pseudonocardia species in the same ant colony that produces an unusual polyene antifungal, providing evidence for co-evolution of Pseudonocardia with A. octospinosus. CONCLUSIONS: Our results show that a combination of co-evolution and environmental sampling results in the diversity of actinomycete symbionts and antibiotics associated with attine ants.
[Mh] Termos MeSH primário: Actinomycetales/metabolismo
Antifúngicos
Formigas/microbiologia
Evolução Biológica
Candicidina/biossíntese
Simbiose
[Mh] Termos MeSH secundário: Actinomycetales/genética
Animais
Sequência de Bases
Bioensaio
Cromatografia Líquida
Dados de Sequência Molecular
Análise de Sequência de DNA
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antifungal Agents); 1403-17-4 (Candicidin)
[Em] Mês de entrada:1101
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100828
[St] Status:MEDLINE
[do] DOI:10.1186/1741-7007-8-109



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