Base de dados : MEDLINE
Pesquisa : D02.540.576.500.999.450 [Categoria DeCS]
Referências encontradas : 19 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 2 ir para página        

  1 / 19 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27816724
[Au] Autor:Zhang C; Yu M; Yang Y; Mu C; Su Y; Zhu W
[Ad] Endereço:Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, Laboratory of Gastrointestinal Microbiology, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China.
[Ti] Título:Effect of early antibiotic administration on cecal bacterial communities and their metabolic profiles in pigs fed diets with different protein levels.
[So] Source:Anaerobe;42:188-196, 2016 Dec.
[Is] ISSN:1095-8274
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study investigated the effects of early antibiotic administration (EAA) on cecal bacterial communities and their metabolic profiles in pigs fed diets with different protein levels. Eighteen litters (total 180) of piglets on day (d) 7 were fed either a commercial creep feed or commercial creep feed + antibiotic (Olaquindox, Oxytetracycline Calcium and Kitasamycin) until d 42. On d 42, pigs within each group were further randomly fed a normal crude protein (CP) diet (20% and 18% CP from d 42 to d 77 and d 77 to d 120, respectively) or a low-CP diet (16% and 14% CP from d 42 to d 77 and d 77 to d 120, respectively), generating 4 groups, control-low CP (Con-LP), control-normal CP (Con-NP), antibiotic-low CP (Ant-LP) and antibiotic-normal CP (Ant-NP), respectively. On d 77 and d 120, 5 pigs per group were slaughtered and cecal materials were collected for bacterial analysis. With cecal bacteria, principle component analysis (PCA) of the denaturing gradient gel electrophoresis (DGGE) profile showed two distinct groups of samples from low-CP diet and samples from normal-CP diet. Real-time PCR showed that EAA did not have significant effect on major bacterial groups, only showed significant interactions (P < 0.05) with CP level for Lactobacillus counts on d 77 and Clostridium cluster XIVa counts on d 120 with higher values in the Con-NP group compared to the Ant-NP groups. Low-CP diet increased (P < 0.05) short-chain fatty acids (SCFA) producing bacteria counts (Bacteroidetes on d 77 and d 120; Clostridium cluster IV and Clostridium cluster XIVa on d 77), but decreased (P < 0.05) Escherichia coli counts on d 77 and d 120. For metabolites, EAA increased (P < 0.05) protein fermentation products (p-cresol, indole and skatole on d 77; ammonia, putrescine and spermidine on d 120), and showed significant interactions (P < 0.05) with CP level for p-cresol and skatole concentrations on d 77 and putrescine and spermidine concentrations on d 120 with higher values in the Ant-LP group compared to the Con-LP groups. Low-CP diet increased (P < 0.05) SCFA concentration (propionate and butyrate) on d 77, but reduced (P < 0.05) the protein fermentation products (ammonia, phenol and indole on d 77; branched chain fatty acid (BCFA), ammonia, tyramine, cadaverine and indole on d 120). These results indicate that EAA had less effect on bacterial communities, but increased bacterial fermentation of protein in the cecum under low-CP diet. Low-CP diet altered bacterial communities with an increase in the counts of SCFA-producing bacteria and a decrease in the counts of Escherichia coli, and markedly reduced the protein fermentation products.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Dieta/métodos
Proteínas na Dieta/administração & dosagem
Kitasamicina/farmacologia
Oxitetraciclina/farmacologia
Quinoxalinas/farmacologia
[Mh] Termos MeSH secundário: Ração Animal/análise
Animais
Animais Lactentes
Bacteroidetes/efeitos dos fármacos
Bacteroidetes/crescimento & desenvolvimento
Bacteroidetes/metabolismo
Ceco/efeitos dos fármacos
Ceco/microbiologia
Clostridium/efeitos dos fármacos
Clostridium/crescimento & desenvolvimento
Clostridium/metabolismo
Proteínas na Dieta/metabolismo
Escherichia coli/efeitos dos fármacos
Escherichia coli/crescimento & desenvolvimento
Escherichia coli/metabolismo
Fermentação/efeitos dos fármacos
Microbioma Gastrointestinal
Lactobacillus/efeitos dos fármacos
Lactobacillus/crescimento & desenvolvimento
Lactobacillus/metabolismo
Análise de Componente Principal
Suínos
Fatores de Tempo
Desmame
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Dietary Proteins); 0 (Quinoxalines); 1392-21-8 (Kitasamycin); G3LAW9U88T (olaquindox); X20I9EN955 (Oxytetracycline)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


  2 / 19 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26339801
[Au] Autor:Zheng Q; Gao S
[Ad] Endereço:State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, People's Republic of China.
[Ti] Título:The effect of surfactant on fermentation of kitasamycin in Streptomyces kitasatoensis.
[So] Source:Biotechnol Appl Biochem;63(6):895-900, 2016 Nov.
[Is] ISSN:1470-8744
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Soybean oil is an important carbon source in kitasamycin fermentation by Streptomyces kitasatoensis. In this study, three different surfactants, Tween 80, Tween 85, and sodium dodecyl sulfate (SDS), were added in the fermentation medium to improve soybean oil utilization. Results indicated that all of these surfactants promote kitasamycin biosynthesis. When 0.5 g/L SDS was added at the beginning of fermentation, kitasamycin production increased by 55% and A content improved by 12%, compared with the control treatment (i.e., no surfactant added). Oil consumption rate and lipase activity were also improved in the presence of SDS, producing more organic acids benefiting kitasamycin biosynthesis. High butyric acid concentration in the fermentation medium containing SDS repressed C-3 acetylation and promoted A component accumulation. Additionally, utilization of oil components by S. kitasatoensis was altered. Specifically, linoleic acid was primarily used in the fermentation process with SDS, whereas oleic acid was primarily used in the fermentation process where no surfactant had been added.
[Mh] Termos MeSH primário: Fermentação/efeitos dos fármacos
Kitasamicina/biossíntese
Streptomyces/efeitos dos fármacos
Streptomyces/metabolismo
Tensoativos/farmacologia
[Mh] Termos MeSH secundário: Ácidos Graxos/biossíntese
Ácidos Graxos/química
Ácidos Graxos/metabolismo
Kitasamicina/metabolismo
Lipase/metabolismo
Óleo de Soja/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Surface-Active Agents); 1392-21-8 (Kitasamycin); 8001-22-7 (Soybean Oil); EC 3.1.1.3 (Lipase)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170207
[Lr] Data última revisão:
170207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150905
[St] Status:MEDLINE
[do] DOI:10.1002/bab.1443


  3 / 19 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:24463847
[Au] Autor:Ding N; Li W; Liu C; Fu Q; Guo B; Li H; Li N; Lin Y
[Ad] Endereço:Institute of Environment, Resource, Soil and Fertilizer, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
[Ti] Título:Decline in extractable kitasamycin during the composting of kitasamycin manufacturing waste with dairy manure and sawdust.
[So] Source:J Environ Manage;134:39-46, 2014 Feb 15.
[Is] ISSN:1095-8630
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to propose a feasible treatment of kitasamycin manufacturing waste by examining extractable kitasamycin and evaluating its compost maturity during the composting of waste with different ratios of dairy manure and sawdust over a 40-day period (volume/volume/volume; M1, 0/80/20; M2, 10/70/20; and M3, 30/50/20). During composting, the concentration of extractable kitasamycin in kitasamycin-contaminated composts declined rapidly, and was undetectable in M2 within 15 days. M2 also achieved the highest fertility compost, which was characterised by the following final parameters: electrical conductivity, 2.34 dS cm(-1); pH, 8.15; total C/N, 22.2; water-soluble NH4(+), P, and K, 0.37, 3.43, and 1.05 g kg(-1), respectively; and plant germination index values, 92%. Furthermore, DGGE analysis showed a dramatic increase in the diversity of bacterial species during composting. In contrast, a high concentration (121 mg kg(-1)) of extractable kitasamycin still remained in the M3 compost, which exerted an inhibitory effect on the composting, resulting in reduced bacterial diversity, high values of electrical conductivity and water-soluble NH4(+), a low C/N ratio, and a low plant germination index value. Furthermore, 3.86 log (CFU g(-1)) kitasamycin-resistant bacteria were still present on day 40, indicating the biological degradation contributed to the decline of extractable kitasamycin.
[Mh] Termos MeSH primário: Antibacterianos/análise
Resíduos Industriais/análise
Kitasamicina/análise
Esterco
Gerenciamento de Resíduos/métodos
Madeira
[Mh] Termos MeSH secundário: Indústria de Laticínios
Solo/química
Microbiologia do Solo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Industrial Waste); 0 (Manure); 0 (Soil); 1392-21-8 (Kitasamycin)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140128
[St] Status:MEDLINE


  4 / 19 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:22490448
[Au] Autor:Wu S; Zhang F; Huang Z; Liu H; Xie C; Zhang J; Thacker PA; Qiao S
[Ad] Endereço:State Key Laboratory of Animal Nutrition, Ministry of Agriculture Feed Industry Centre, China Agricultural University, Beijing 100193, China.
[Ti] Título:Effects of the antimicrobial peptide cecropin AD on performance and intestinal health in weaned piglets challenged with Escherichia coli.
[So] Source:Peptides;35(2):225-30, 2012 Jun.
[Is] ISSN:1873-5169
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study was conducted to determine the effects of the antimicrobial peptide cecropin on performance and intestinal health in piglets. Newly weaned barrows were randomly assigned to one of three treatments (n=8), including a corn-soybean basal diet or similar diets supplemented with antibiotics (100 mg/kg kitasamycin plus 800 mg/kg colistin sulfate) or 400 mg/kg cecropin AD. On day 13, all piglets were orally challenged with 10(9)CFU/mL of Escherichia coli K88. On day 19, all piglets were euthanized and sampled. Before challenge, piglets fed antibiotics had greater weight gain, feed efficiency, nitrogen and energy retention than the control (P<0.05). E. coli challenge decreased weight gain, feed intake and feed efficiency for the control piglets (P<0.05) but not for the antibiotic or cecropin AD treated piglets. The incidence of diarrhea post-challenge in the antibiotic and cecropin AD treatments decreased compared with the control piglets. The total viable counts of cecal E. coli were lower while the Lactobacilli counts were higher in the antibiotic and cecropin AD treatments compared with the control (P<0.05). Cecropin AD treatment decreased total aerobes while increasing total anaerobes in the ileum (P<0.05). A higher villus height to crypt depth ratio in the jejunum and ileum as well as a deeper crypt depth in the jejunum and higher villus height in the ileum were observed in piglets fed antibiotics or cecropin AD compared with control piglets (P<0.05). Piglets fed the control diet had lower levels of secretory IgA in their jejunum and lower serum IgA, IgG, interleukin-1ß and interleukin-6 compared with the other treatments (P<0.05). Overall, these data suggest that cecropin AD enhances pig performance through increasing immune status and nitrogen and energy retention as well as reducing intestinal pathogens in weaned piglets.
[Mh] Termos MeSH primário: Anti-Infecciosos/administração & dosagem
Infecções por Escherichia coli/veterinária
Proteínas de Insetos/administração & dosagem
Intestinos
Doenças dos Suínos/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Colistina/farmacologia
Diarreia/tratamento farmacológico
Diarreia/microbiologia
Diarreia/veterinária
Ingestão de Alimentos/efeitos dos fármacos
Escherichia coli/efeitos dos fármacos
Infecções por Escherichia coli/tratamento farmacológico
Infecções por Escherichia coli/imunologia
Imunoglobulina A Secretora/análise
Imunoglobulina A Secretora/sangue
Imunoglobulina G/sangue
Interleucina-1beta/sangue
Interleucina-6/sangue
Intestinos/efeitos dos fármacos
Intestinos/microbiologia
Intestinos/fisiologia
Kitasamicina/farmacologia
Lactobacillus/isolamento & purificação
Suínos
Doenças dos Suínos/imunologia
Ganho de Peso/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Immunoglobulin A, Secretory); 0 (Immunoglobulin G); 0 (Insect Proteins); 0 (Interleukin-1beta); 0 (Interleukin-6); 116811-00-8 (cecropin AD protein, insect); 1392-21-8 (Kitasamycin); Z67X93HJG1 (Colistin)
[Em] Mês de entrada:1211
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120412
[St] Status:MEDLINE
[do] DOI:10.1016/j.peptides.2012.03.030


  5 / 19 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:20414322
[Au] Autor:Anzai Y; Sakai A; Li W; Iizaka Y; Koike K; Kinoshita K; Kato F
[Ad] Endereço:Department of Microbiology, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan. yanzai@phar.toho-u.ac.jp
[Ti] Título:Isolation and characterization of 23-O-mycinosyl-20-dihydro-rosamicin: a new rosamicin analogue derived from engineered Micromonospora rosaria.
[So] Source:J Antibiot (Tokyo);63(6):325-8, 2010 Jun.
[Is] ISSN:0021-8820
[Cp] País de publicação:Japan
[La] Idioma:eng
[Mh] Termos MeSH primário: Antibacterianos/isolamento & purificação
Kitasamicina/análogos & derivados
Leucomicinas/isolamento & purificação
Micromonospora/metabolismo
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Bactérias/efeitos dos fármacos
Cromatografia Líquida de Alta Pressão
Engenharia Genética
Leucomicinas/farmacologia
Testes de Sensibilidade Microbiana
Micromonospora/genética
Ressonância Magnética Nuclear Biomolecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (23-O-mycinosyl-20-dihydro-rosamicin); 0 (Anti-Bacterial Agents); 0 (Leucomycins); 1392-21-8 (Kitasamycin); E907BNQ7SH (rosaramicin)
[Em] Mês de entrada:1007
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100424
[St] Status:MEDLINE
[do] DOI:10.1038/ja.2010.38


  6 / 19 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:20090988
[Au] Autor:Yang B; Zöllner T; Gebhardt P; Möllmann U; Miller MJ
[Ad] Endereço:Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland ScienceHall, Notre Dame, Indiana 46556, USA.
[Ti] Título:Preparation and biological evaluation of novel leucomycin analogs derived from nitroso Diels-Alder reactions.
[So] Source:Org Biomol Chem;8(3):691-7, 2010 Feb 07.
[Is] ISSN:1477-0539
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A series of 10,13-disubstituted 16-membered macrolides was synthesized using nitroso Diels-Alder reactions of leucomycin A7. Despite the extensive constituent functionalities in leucomycin, the hetero cycloaddition reactions proceeded in a highly regio- and stereoselective fashion. Subsequent chemical modifications of the nitroso cycloadducts, including N-O bond reduction, were also conducted. Most leucomycin derivatives retained antibiotic profiles similar to leucomycin A7, and, in contrast to leucomycin itself, several exhibited moderate antiproliferative and cytotoxic activity.
[Mh] Termos MeSH primário: Antibacterianos/química
Antibacterianos/farmacologia
Kitasamicina/análogos & derivados
Kitasamicina/farmacologia
Compostos Nitrosos/química
[Mh] Termos MeSH secundário: Animais
Antibacterianos/síntese química
Antibacterianos/toxicidade
Bactérias/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Seres Humanos
Kitasamicina/síntese química
Kitasamicina/química
Kitasamicina/toxicidade
Camundongos
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Nitroso Compounds); 1392-21-8 (Kitasamycin)
[Em] Mês de entrada:1003
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100122
[St] Status:MEDLINE
[do] DOI:10.1039/b922450e


  7 / 19 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:18986810
[Au] Autor:Miura T; Kanemoto K; Natsume S; Atsumi K; Fushimi H; Yoshida T; Ajito K
[Ad] Endereço:Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan. tomoaki_miura@meiji.co.jp
[Ti] Título:Novel azalides derived from 16-membered macrolides. Part II: Isolation of the linear 9-formylcarboxylic acid and its sequential macrocyclization with an amino alcohol or an azidoamine.
[So] Source:Bioorg Med Chem;16(23):10129-56, 2008 Dec 01.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The design and synthesis of novel 14- to 16-membered 11-azalides starting from 16-membered macrolides are reported. A linear 9-formylcarboxylic acid was isolated via a mobile dialdehyde previously reported. Sequential macrocyclization of the formylcarboxylic acid with amino alcohol followed by deprotection afforded corresponding 14- to 16-membered azalides. On the other hand, reductive amination of the formylcarboxylic acid with an azidoamine followed by macrolactam formation with an amine generated from the azide gave 14- to 16-membered azalactams. Among these derivatives, 15-membered azalactams and 16-membered azalides exhibited characteristic in vitro antibacterial activities. Although optimization of 15-membered azalactams including demycarosyl analogues did not provide remarkably promising molecules, SAR studies of 16-membered azalides disclosed that substitution at the 15 position was very important for identification of a clinical candidate.
[Mh] Termos MeSH primário: Antibacterianos/síntese química
Compostos Aza/síntese química
Macrolídeos/síntese química
[Mh] Termos MeSH secundário: Amino Álcoois/química
Antibacterianos/química
Antibacterianos/farmacologia
Compostos Aza/química
Compostos Aza/farmacologia
Azitromicina/análogos & derivados
Azitromicina/farmacologia
Ácidos Carboxílicos/química
Kitasamicina/síntese química
Kitasamicina/química
Kitasamicina/farmacologia
Macrolídeos/química
Macrolídeos/farmacologia
Testes de Sensibilidade Microbiana
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Alcohols); 0 (Anti-Bacterial Agents); 0 (Aza Compounds); 0 (Carboxylic Acids); 0 (Macrolides); 1392-21-8 (Kitasamycin); 83905-01-5 (Azithromycin)
[Em] Mês de entrada:0901
[Cu] Atualização por classe:081117
[Lr] Data última revisão:
081117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:081107
[St] Status:MEDLINE
[do] DOI:10.1016/j.bmc.2008.09.054


  8 / 19 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:18329276
[Au] Autor:Furuuchi T; Miura T; Kurihara K; Yoshida T; Watanabe T; Ajito K
[Ad] Endereço:Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama 222-8567, Japan. takeshi_furuuchi@meiji.co.jp
[Ti] Título:Design and synthesis of novel leucomycin analogues modified at the C-3 position. Part II: 3-O-(3-Aryl-2-propenyl)leucomycin analogues.
[So] Source:Bioorg Med Chem;16(8):4401-18, 2008 Apr 15.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The design and synthesis of 16-membered macrolides modified at the C-3 position are described. Starting from fully protected intermediate (5), appropriate modifications including Heck reaction were performed to furnish 3-O-(3-aryl-2-propenyl)leucomycin A(7) analogues (9a-9m). These leucomycin A(7) derivatives showed improved in vitro antibacterial activities against clinically important pathogens including erythromycin-resistant Streptococcus pneumoniae (ERSP). SAR analysis of derivatives modified at the C-3 and C-3'' positions suggested that single modification at C-3 or C-3'' was effective for in vitro antibacterial activity.
[Mh] Termos MeSH primário: Antibacterianos/síntese química
Antibacterianos/farmacologia
Desenho de Drogas
Kitasamicina/síntese química
Kitasamicina/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Benzoquinonas/química
Cristalografia por Raios X
Kitasamicina/análogos & derivados
Kitasamicina/química
Miocamicina/análogos & derivados
Miocamicina/síntese química
Miocamicina/química
Miocamicina/farmacologia
Modelos Moleculares
Estrutura Molecular
Streptococcus/efeitos dos fármacos
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Benzoquinones); 1392-21-8 (Kitasamycin); 3T006GV98U (quinone); 3T48CPS7U2 (Miocamycin); ZPT03UEM0E (rokitamycin)
[Em] Mês de entrada:0805
[Cu] Atualização por classe:161124
[Lr] Data última revisão:
161124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080311
[St] Status:MEDLINE
[do] DOI:10.1016/j.bmc.2008.02.064


  9 / 19 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:17721001
[Au] Autor:Miura T; Natsume S; Kanemoto K; Atsumi K; Fushimi H; Sasai H; Arai T; Yoshida T; Ajito K
[Ad] Endereço:Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
[Ti] Título:Novel azalides derived from sixteen-membered macrolides.
[So] Source:J Antibiot (Tokyo);60(7):407-35, 2007 Jul.
[Is] ISSN:0021-8820
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The design and synthesis of novel 15-membered 11-azalides and 16-membered 11,12-diazalide starting from 16-membered macrolides are reported. A mobile linear dialdehyde was isolated via a cyclic tetraol which was prepared by osmium oxidation of a conjugated diene. One-pot macrocyclization of this dialdehyde with an amine or a diamine afforded corresponding 15-membered azalides or 11,12-diazalide. Fundamental SAR studies of 15-membered 11-azalides disclosed their potentiality as a lead molecule for further chemical modifications. For environmental preservation, sustainable chemistry for synthesis of these azalides is also discussed.
[Mh] Termos MeSH primário: Antibacterianos/síntese química
Antibacterianos/farmacologia
Compostos Aza/síntese química
Azitromicina/análogos & derivados
Macrolídeos/síntese química
Macrolídeos/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Compostos Aza/farmacologia
Azitromicina/química
Azitromicina/farmacologia
Bactérias/efeitos dos fármacos
Seres Humanos
Kitasamicina/síntese química
Kitasamicina/farmacologia
Compostos Macrocíclicos
Macrolídeos/química
Testes de Sensibilidade Microbiana
Uridina Monofosfato/análogos & derivados
Uridina Monofosfato/síntese química
Uridina Monofosfato/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Aza Compounds); 0 (Macrocyclic Compounds); 0 (Macrolides); 1392-21-8 (Kitasamycin); 63436-29-3 (UMP dialdehyde); 83905-01-5 (Azithromycin); E2OU15WN0N (Uridine Monophosphate)
[Em] Mês de entrada:0711
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070828
[St] Status:MEDLINE


  10 / 19 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:17257795
[Au] Autor:González de la Huebra MJ; Vincent U; von Holst C
[Ad] Endereço:European Commission, Directorate General Joint Research Centre, Institute for Reference Materials and Measurements, Retieseweg 111, B-2440 Geel, Belgium. maria-jose.gonzalez-de-la-huebra@ec.europa.eu
[Ti] Título:Sample preparation strategy for the simultaneous determination of macrolide antibiotics in animal feedingstuffs by liquid chromatography with electrochemical detection (HPLC-ECD).
[So] Source:J Pharm Biomed Anal;43(5):1628-37, 2007 Apr 11.
[Is] ISSN:0731-7085
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel and suitable clean-up method that allows, for the first time, the simultaneous determination of a rather large number of macrolide antibiotics (erythromycin, rosamicin, spiramycin, tylosin, kitasamycin and josamycin in feedingstuffs by high performance liquid chromatography with electrochemical detection (HPLC-ECD) is presented in this work. The effectiveness of the developed clean-up method allows the quantification of the target macrolides in poultry feed using standard calibration curves instead of matrix matched standards, which overcomes the general problem of finding representative blanks. Furthermore an additional back extraction included in the sample preparation procedure allows the determination of an additional macrolide (oleandomycin) with detection limits, expressed as apparent concentration in poultry feed, ranging from 0.04 to 0.22 mg kg(-1) and relative standard deviation values ranging from 3.6 to 10.1% depending on the target analyte. Moreover, this additional step has been proven to enlarge the scope of the method by the extension of its applicability, at the target level of concentration, to other animal feedingstuffs such as pig and cattle. The analysis of real feedingstuffs containing macrolides demonstrated the fitness for purpose of the whole analytical procedure as well as a good fitting between real and spiked samples. The proposed methods appeared therefore as a sound alternative in the frame of control (e.g. for post-screening purposes) and/or monitoring surveillance programmes at the target level of 1.0 mg kg(-1) established according to the reported lowest dosage of additive needed to lead a growth promoting effect.
[Mh] Termos MeSH primário: Ração Animal/análise
Antibacterianos/análise
Cromatografia Líquida de Alta Pressão/métodos
Cromatografia Líquida/métodos
Eletroquímica/métodos
Macrolídeos/análise
[Mh] Termos MeSH secundário: Animais
Antibacterianos/isolamento & purificação
Bovinos
Eritromicina/análise
Eritromicina/isolamento & purificação
Josamicina/análise
Josamicina/isolamento & purificação
Kitasamicina/análise
Kitasamicina/isolamento & purificação
Leucomicinas/análise
Leucomicinas/isolamento & purificação
Macrolídeos/isolamento & purificação
Oleandomicina/análise
Oleandomicina/isolamento & purificação
Aves Domésticas
Espiramicina/análise
Espiramicina/isolamento & purificação
Suínos
Fatores de Tempo
Tilosina/análise
Tilosina/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Leucomycins); 0 (Macrolides); 1392-21-8 (Kitasamycin); 63937KV33D (Erythromycin); 8025-81-8 (Spiramycin); E907BNQ7SH (rosaramicin); HV13HFS217 (Josamycin); P8ZQ646136 (Oleandomycin); YEF4JXN031 (Tylosin)
[Em] Mês de entrada:0706
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070130
[St] Status:MEDLINE



página 1 de 2 ir para página        
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde