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| [PMID]: | 28100342 |
| [Au] Autor: | Wang ZQ; Chen MX; Liu DL; Zheng WX; Cao XZ; Chen H; Huang MF; Luo ZR |
| [Ad] Endereço: | Department of Cardiology, Fuzhou General Hospital of Nanjing Military Command, Xiamen University, Fuzhou 350025, China. |
| [Ti] Título: | [The effect on myocardial perfusion and clinical outcome of intracoronary nicorandil injection prior to percutaneous coronary intervention in ST-segment elevation myocardial infarction]. |
| [So] Source: | Zhonghua Xin Xue Guan Bing Za Zhi;45(1):26-33, 2017 Jan 25. | | [Is] ISSN: | 0253-3758 |
| [Cp] País de publicação: | China |
| [La] Idioma: | chi |
| [Ab] Resumo: | To investigate the effect of intracoronary administration of nicorandil prior to primary percutaneous coronary intervention (PPCI) on myocardial perfusion and short-term clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI). A total of 158 patients with STEMI undergoing PPCI from January 2014 to December 2015 in Fuzhou General Hospital were enrolled consecutively in this prospective controlled randomized trial. Patients were assigned into three groups with random number table: the nicorandil group (patients received intracoronary administration of 6 mg nicorandil after guide wire or balloon successfully crossed the target lesion, =53), the nitroglycerin group (patients received intracoronary administration of 300 µg nitroglycerin after after guide wire or balloon successfully crossed the target lesion, =52) and the control group(patients received routine treatment, =53). The primary outcomes were myocardial perfusion, including the levels of corrected TIMI frame count (cTFC), and the incidence of no reflow or slow flow after PPCI. The secondary outcomes included the incidence of major adverse cardiovascular events (MACE) during hospitalization (all-cause death, reperfusion arrhythmia within 2 hours after PPCI, angina within 24 hours after PPCI, new heart failure or worsening cardiac function, and repeat revascularization) and within 3 months of follow-up (all-cause death, nonfatal myocardial infarction, repeat revascularization, post-infarction angina, and re-hospitalization for congestive heart failure). The age of enrolled patients was (62.9±11.3) years old, and 130 cases (82.3%) of them were male. The median time of symptom-onset to balloon was 4.50 (3.20, 6.43) hours. There were significantly difference in cTFC immediately after PPCI((21.68±7.43)frames, (24.74±8.66)frames, and(27.06±10.40)frames), incidence of no reflow or slow flow after PPCI(5.7%(3/53), 13.5%(7/52), and 22.6%(12/53)), ST-segment resolution at 2 hours after procedure(90.6%(48/53), 84.6%(44/52), and 74.5%(38/53)), and reperfusion arrhythmia at 2 hours after procedure(15.1%(8/53), 36.6%(19/52), and 34.0%(18/53)) among the 3 groups( <0.01 or 0.05). In the multivariate logistic regression models, intracoronary administration of nicorandil could lower the cTFC level ( =0.17, 95% 0.10-0.41, =0.001), acted as a protecting factor on lowering the incidence of no reflow or slow flow ( =0.13, 95% 0.02-0.96, =0.045) and reperfusion arrhythmia ( =0.26, 95% 0.09-0.74, =0.012), as well as facilitating the ST-segment resolution at 2 hours after procedure ( =4.62, 95% 1.14-18.82, =0.033). However, observed parameters were similar between intracoronary administration of nitroglycerin group compared with control group (all >0.05). MACE within 3 months of follow-up were similar among the 3 groups(all >0.05). Intracoronary administration of nicorandil prior to balloon dilation can significantly improve the myocardial perfusion and reduce the occurrence of reperfusion arrhythmia during PPCI for STEMI, but does not affect the short-term prognosis in STEMI patients. |
| [Mh] Termos MeSH primário: |
Infarto do Miocárdio/tratamento farmacológico
Nicorandil/uso terapêutico
Intervenção Coronária Percutânea
Vasodilatadores/uso terapêutico
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| [Mh] Termos MeSH secundário: |
Idoso
Angioplastia Coronária com Balão
Arritmias Cardíacas
Feminino
Seres Humanos
Masculino
Meia-Idade
Nitroglicerina
Prognóstico
Estudos Prospectivos
Infarto do Miocárdio com Supradesnível do Segmento ST
Resultado do Tratamento
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| [Pt] Tipo de publicação: | JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL |
[Nm] Nome de substância:
| 0 (Vasodilator Agents); 260456HAM0 (Nicorandil); G59M7S0WS3 (Nitroglycerin) |
| [Em] Mês de entrada: | 1707 |
| [Cu] Atualização por classe: | 170727 |
[Lr] Data última revisão:
| 170727 |
| [Sb] Subgrupo de revista: | IM |
| [Da] Data de entrada para processamento: | 170120 |
| [St] Status: | MEDLINE |
| [do] DOI: | 10.3760/cma.j.issn.0253-3758.2017.01.006 |
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