Base de dados : MEDLINE
Pesquisa : D02.626.095 [Categoria DeCS]
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[PMID]:28613844
[Au] Autor:Williams GM; Kobets T; Duan JD; Iatropoulos MJ
[Ad] Endereço:Chemical Safety Program, Department of Pathology, New York Medical College , Valhalla, New York 10595, United States.
[Ti] Título:Assessment of DNA Binding and Oxidative DNA Damage by Acrylonitrile in Two Rat Target Tissues of Carcinogenicity: Implications for the Mechanism of Action.
[So] Source:Chem Res Toxicol;30(7):1470-1480, 2017 Jul 17.
[Is] ISSN:1520-5010
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Exposure to acrylonitrile induces formation of tumors at multiple sites in rats, with females being more sensitive. The present study assessed possible mechanisms of acrylonitrile tumorigenicity, covalent DNA binding, DNA breakage, and oxidative DNA damage, in two target tissues, the brain and Zymbal's glands, of sensitive female Fischer (F344) and Sprague-Dawley (SD) rats. One group received acrylonitrile in drinking water at 100 ppm for 28 days. Two other groups were administered either acrylonitrile in drinking water at 100 ppm or drinking water alone for 27 days, followed by a single oral gavage dose of 11 mg/kg bw C-acrylonitrile on day 28. A positive control group received a single dose of 5 mg/kg bw of 7- C-benzo[a]pyrene, on day 27 following the administration of drinking water for 26 days. Using liquid scintillation counting, no association of radiolabeled acrylonitrile with brain DNA was found. In accelerator mass spectrometry analysis, the association of C of acrylonitrile with DNA in brains was detected and was similar in both strains, which may reflect acrylonitrile binding to protein as well as to DNA. Nucleotide P-postlabeling assay analysis of brain samples from rats of both strains yielded no evidence of acrylonitrile DNA adducts. Negative conventional comet assay results indicate the absence of direct DNA strand breaks in the brain and Zymbal's gland in both strains of rats dosed with acrylonitrile. In both rat strains, positive results in an enhanced comet assay were found only in brain samples digested with formamidopyrimidine-DNA glycosylase but not with human 8-hydroxyguanine-DNA glycosylase, indicating possible oxidative DNA damage, other than 8-oxodG formation. In conclusion, definitive evidence of DNA binding of acrylonitrile in the brain and Zymbal's gland was not obtained under the test conditions. A role for oxidative stress in tumorigenesis in the brain but not Zymbal's gland may exist.
[Mh] Termos MeSH primário: Acrilonitrila/farmacologia
Dano ao DNA
DNA/química
DNA/efeitos dos fármacos
[Mh] Termos MeSH secundário: Acrilonitrila/administração & dosagem
Administração Oral
Animais
Sítios de Ligação/efeitos dos fármacos
Testes de Carcinogenicidade
Relação Dose-Resposta a Droga
Feminino
Oxirredução
Ratos
Ratos Endogâmicos F344
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9007-49-2 (DNA); MP1U0D42PE (Acrylonitrile)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1021/acs.chemrestox.7b00105


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[PMID]:28544987
[Au] Autor:Dong H; Wang W; Song Z; Dong H; Wang J; Sun S; Zhang Z; Ke M; Zhang Z; Wu WM; Zhang G; Ma J
[Ad] Endereço:State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Beijing 102249, PR China.
[Ti] Título:A high-efficiency denitrification bioreactor for the treatment of acrylonitrile wastewater using waterborne polyurethane immobilized activated sludge.
[So] Source:Bioresour Technol;239:472-481, 2017 Sep.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The performance of a laboratory-scale, high-efficiency denitrification bioreactor (15L) using activated sludge immobilized by waterborne polyurethane in treating acrylonitrile wastewater with high concentration of nitrate nitrogen (249mg/L) was investigated. The bioreactor was operated at 30°C for 220days. Batch denitrification experiments showed that the optimal operation parameters were C/NO -N molar ratio of 2.0 using sodium acetate as electron donor and carrier filling rate of 20% (V/V) in the bioreactor. Stable performance of denitrification was observed with a hydraulic retention time of 30 to 38h. A volumetric removal rate up to 2.1kgN/m ·d was achieved with a total nitrogen removal efficiency of 95%. Pyrosequencing results showed that Rhodocyclaceae and Pseudomonadaceae were the dominant bacterial families in the immobilized carrier and bioreactor effluent. The overall microbial diversity declined as denitrifiers gradually dominated and the relative abundance of other bacteria decreased along with testing time.
[Mh] Termos MeSH primário: Reatores Biológicos
Desnitrificação
Águas Residuais
[Mh] Termos MeSH secundário: Acrilonitrila
Nitrogênio
Poliuretanos
Esgotos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Polyurethanes); 0 (Sewage); 0 (Waste Water); MP1U0D42PE (Acrylonitrile); N762921K75 (Nitrogen)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE


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[PMID]:28500995
[Au] Autor:AlNeyadi SS; Salem AA; Ghattas MA; Atatreh N; Abdou IM
[Ad] Endereço:Department of Chemistry, College of Science, UAE University Al-Ain, 15551, United Arab Emirates.
[Ti] Título:Antibacterial activity and mechanism of action of the benzazole acrylonitrile-based compounds: In vitro, spectroscopic, and docking studies.
[So] Source:Eur J Med Chem;136:270-282, 2017 Aug 18.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:A new series of pyrimidine derivatives 5, 9a-d and 12a-d was synthesized by an efficient procedure. The antibacterial activity of the new compounds was studied against four bacterial strains. Compound 5 was found to exhibit the highest potency, with = 1.0 µg/ml, against both Escherichia coli and Pseudomonas aeruginosa when compared with amoxicillin (MIC = 1.0-1.5 µg/mL). Transmission electron microscope results confirmed that activities against bacteria occurred via rupturing of the cell wall. Molecular modeling results suggested that compounds 5, 9a-d and 12a-d have the potential to irreversibly bind to the penicillin-binding protein (PBP) Ser62 residue in the active site and were able to overcome amoxicillin resistance in bacteria by inhibiting the ß-lactamase enzyme. Docking studies showed that compounds 5, 9a-d and 12a-d inhibit the ß-lactamase enzyme through covalent bonding with Ser70. The synergistic effect with amoxicillin was studied. The newly synthesized compounds reported in this study warrant further consideration as prospective antimicrobial agents.
[Mh] Termos MeSH primário: Acrilonitrila/farmacologia
Antibacterianos/farmacologia
Escherichia coli/efeitos dos fármacos
Pseudomonas aeruginosa/efeitos dos fármacos
Inibidores de beta-Lactamases/farmacologia
beta-Lactamases/metabolismo
[Mh] Termos MeSH secundário: Acrilonitrila/síntese química
Acrilonitrila/química
Antibacterianos/síntese química
Antibacterianos/química
Dicroísmo Circular
Relação Dose-Resposta a Droga
Escherichia coli/enzimologia
Espectroscopia de Ressonância Magnética
Testes de Sensibilidade Microbiana
Simulação de Acoplamento Molecular
Estrutura Molecular
Pseudomonas aeruginosa/enzimologia
Espectrofotometria Ultravioleta
Relação Estrutura-Atividade
Inibidores de beta-Lactamases/síntese química
Inibidores de beta-Lactamases/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (beta-Lactamase Inhibitors); EC 3.5.2.6 (beta-Lactamases); MP1U0D42PE (Acrylonitrile)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170514
[St] Status:MEDLINE


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[PMID]:28412618
[Au] Autor:Mandegari M; Fashandi H
[Ad] Endereço:Department of Textile Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran.
[Ti] Título:Untapped potentials of acrylonitrile-butadiene-styrene/polyurethane (ABS/PU) blend membrane to purify dye wastewater.
[So] Source:J Environ Manage;197:464-475, 2017 Jul 15.
[Is] ISSN:1095-8630
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Production of acrylonitrile-butadiene-styrene/polyurethane (ABS/PU) blend membrane with high rejection efficiency for disperse and vat dyes, is introduced as a facile and cost effective technique to purify textile wastewater. In this respect, membranes are produced using commercially available polymers, i.e. ABS and PU, with different compositions (ABS/PU: 100/0, 80/20, 70/30, 60/40 and 50/50 w/w) through wet casting. Casting solutions with concentration of 30 wt% are prepared using two different solvents, i.e. dimethylformamide (DMF) and N-methyl-2- pyrrolidone (NMP). The prepared membranes are characterized using a variety of analytical techniques including SEM imaging, FTIR spectroscopy, dry and wet gas permeation, evaluation of reusability, antifouling and mechanical properties, photostability, surface hydrophilicity and pure water permeability (PWP) of the produced membranes. According to the results, irrespective of solvent type, ABS/PU membranes with higher PU content have lower porosity and smaller pore size both of which contribute to enhanced dye rejection efficiency. This is while the impact of PU content on the photostability of ABS/PU membranes was found to be negligible. Additionally, the produced ABS/PU membranes exhibit good reusability and antifouling properties. However, the mechanical properties of ABS/PU membranes with higher PU contents are inferior to those with lower PU contents. This contrast highlights the prominence of optimum PU content to make a trade-off between dye rejection efficiency and mechanical properties. In this regard, ABS/PU (60/40 w/w) membrane is recognized as the one with optimum composition. Furthermore, it was found that regardless of PU content, membranes cast from DMF-based solutions exhibit superior rejection performance over those cast from NMP-based solutions. Overall, one can witness that employing ABS/PU membranes provides a meritorious and clean approach to refine disperse and vat dye wastewaters, a great threat to the environment and human health.
[Mh] Termos MeSH primário: Águas Residuais
Poluentes Químicos da Água
[Mh] Termos MeSH secundário: Acrilonitrila
Butadienos
Seres Humanos
Poliuretanos
Estireno
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butadienes); 0 (Polyurethanes); 0 (Waste Water); 0 (Water Pollutants, Chemical); 44LJ2U959V (Styrene); MP1U0D42PE (Acrylonitrile)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170417
[St] Status:MEDLINE


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[PMID]:28278771
[Au] Autor:Dong W; Peng B; Wang K; Miao J; Zhang W; Zhang Y; Shen Z
[Ad] Endereço:a State Key Laboratory of Pollution Control and Resources Reuse, National Engineering Research Center of Facilities Agriculture, Key Laboratory of Yangtze River Water Environment of Ministry of Education , College of Environmental Science and Engineering, Tongji University , Shanghai , People's Repu
[Ti] Título:An effective method and pathways of acrylonitrile degradation to acrylic acid through an alkaline hydrothermal system.
[So] Source:Environ Technol;38(13-14):1702-1707, 2017 Jul.
[Is] ISSN:0959-3330
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Degradation of pollution for specific chemicals represents an optimal approach to high-strength wastewater treatment. One-pot selective conversion of acrylonitrile to acrylic acid in a hydrothermal system with NaOH as a catalyst was carried out. The influence factors were evaluated, including initial acrylonitrile concentration, reaction temperature, reaction time and amount of alkali. Experimental results showed that the highest yield of acrylic acid (55%) was obtained at the initial acrylonitrile concentration of 3 × 10 mg/L, 300°C for 90 s with 1.0 M NaOH. To determine the reaction path, intermediates analysis and calculation of carbon and nitrogen balance were carried out by means of HPLC, GC and TOC/TN methods. Two probable reaction pathways were proposed as follows: (1) Acrylonitrile was hydrolyzed into acrylamide, and acrylic acid was obtained via further hydrolysis. (2) Acrylonitrile was converted into 3-hydroxy-propionitrile via additive reaction, and this product was readily converted to 3-hydroxy-propionic acid through two steps of hydrolysis, followed by dehydration reaction to produce acrylic acid. This study offered not only an efficient method to transfer highly toxic pollutants into valuable chemical, but also a better understanding of hydrothermal alkali catalytic reaction.
[Mh] Termos MeSH primário: Acrilatos/química
Acrilonitrila/química
[Mh] Termos MeSH secundário: Catálise
Hidróxido de Sódio/química
Temperatura Ambiente
Gerenciamento de Resíduos/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylates); 55X04QC32I (Sodium Hydroxide); J94PBK7X8S (acrylic acid); MP1U0D42PE (Acrylonitrile)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1080/09593330.2017.1293162


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[PMID]:28264791
[Au] Autor:Kandolf Sekulovic L; Peris K; Hauschild A; Stratigos A; Grob JJ; Nathan P; Dummer R; Forsea AM; Hoeller C; Gogas H; Demidov L; Lebbe C; Blank C; Olah J; Bastholt L; Herceg D; Neyns B; Vieira R; Hansson J; Rutkowski P; Krajsova I; Bylaite-Bucinskiene M; Zalaudek I; Maric-Brozic J; Babovic N; Banjin M; Putnik K; Weinlich G; Todorovic V; Kirov K; Ocvirk J; Zhukavets A; Kukushkina M; De La Cruz Merino L; Ymeri A; Risteski M; Garbe C
[Ad] Endereço:Department of Dermatology, Medical Faculty, Military Medical Academy, Belgrade, Serbia.
[Ti] Título:More than 5000 patients with metastatic melanoma in Europe per year do not have access to recommended first-line innovative treatments.
[So] Source:Eur J Cancer;75:313-322, 2017 Apr.
[Is] ISSN:1879-0852
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Despite the efficacy of innovative treatments for metastatic melanoma, their high costs has led to disparities in cancer care among different European countries. We analysed the availability of these innovative therapies in Europe and estimated the number of patients without access to first-line recommended treatment per current guidelines of professional entities such as the European Society for Medical Oncology (ESMO), the European Organisation for Research and Treatment of Cancer (EORTC), the European Association of Dermato-Oncology (EADO), and European Dermatology Forum (EDF). MATERIALS AND METHODS: Web-based online survey was conducted in 30 European countries with questions about the treatment schedules from 1st May 2015 to 1st May 2016: number of metastatic melanoma patients, registration and reimbursement of innovative medicines (updated data, as of 1st October 2016), percentage of patients treated and availability of clinical studies and compassionate-use programmes. RESULTS: The recommended BRAF inhibitor (BRAFi) + MEK inhibitor (MEKi) combination was both registered and fully reimbursed in 9/30 (30%) countries, and in 13/30 (43%) (all from Eastern Europe) not reimbursed. First-line immunotherapy with anti-PD1 antibodies was registered and fully reimbursed in 14/30 (47%) countries, while in 13/30 (43%) (all from Eastern Europe) not reimbursed. It was estimated that in Europe 19,600 patients with metastatic melanoma are treated, and 5238 (27%) do not have access to recommended first-line therapy. Significant correlation was found between human development index (HDI, UNDP report 2015), (r = 0.662; p < 0.001), health expenditure per capita (r = 0.695; p < 0.001) and the Mackenbach score of health policy performance (r = 0.765; p < 0.001) with the percentage of patients treated with innovative medicines and a number of reimbursed medicines. CONCLUSIONS: Great discrepancy exists in metastatic melanoma treatment across Europe. It is crucial to increase the awareness of national and European policymakers, oncological societies, melanoma patients' associations and pharma industry.
[Mh] Termos MeSH primário: Disparidades em Assistência à Saúde/estatística & dados numéricos
Melanoma/terapia
Neoplasias Cutâneas/terapia
Terapias em Estudo/estatística & dados numéricos
[Mh] Termos MeSH secundário: Acrilonitrila/análogos & derivados
Acrilonitrila/economia
Acrilonitrila/provisão & distribuição
Compostos de Anilina/economia
Compostos de Anilina/provisão & distribuição
Anticorpos Monoclonais Humanizados/economia
Anticorpos Monoclonais Humanizados/uso terapêutico
Europa (Continente)/epidemiologia
Feminino
Acesso aos Serviços de Saúde/economia
Acesso aos Serviços de Saúde/estatística & dados numéricos
Disparidades em Assistência à Saúde/economia
Seres Humanos
Imunoterapia/economia
Imunoterapia/estatística & dados numéricos
Masculino
Melanoma/economia
Melanoma/epidemiologia
Receptor de Morte Celular Programada 1/antagonistas & inibidores
Proteínas Proto-Oncogênicas B-raf/antagonistas & inibidores
Mecanismo de Reembolso/estatística & dados numéricos
Neoplasias Cutâneas/economia
Neoplasias Cutâneas/epidemiologia
Terapias em Estudo/economia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aniline Compounds); 0 (Antibodies, Monoclonal, Humanized); 0 (MEK inhibitor I); 0 (PDCD1 protein, human); 0 (Programmed Cell Death 1 Receptor); EC 2.7.11.1 (BRAF protein, human); EC 2.7.11.1 (Proto-Oncogene Proteins B-raf); MP1U0D42PE (Acrylonitrile)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE


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[PMID]:28161337
[Au] Autor:Liu G; Liao Y; Ma X
[Ad] Endereço:Guangdong Key Laboratory of Efficient and Clean Energy Utilization Institutes, School of Electric Power, South China University of Technology, Guangzhou 510640, PR China.
[Ti] Título:Thermal behavior of vehicle plastic blends contained acrylonitrile-butadiene-styrene (ABS) in pyrolysis using TG-FTIR.
[So] Source:Waste Manag;61:315-326, 2017 Mar.
[Is] ISSN:1879-2456
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:As important plastic blends in End-of-Life vehicles (ELV), pyrolysis profiles of ABS/PVC, ABS/PA6 and ABS/PC were investigated using thermogravimetric-Fourier transform infrared spectrometer (TG-FTIR). Also, CaCO was added as plastic filler to discuss its effects on the pyrolysis of these plastics. The results showed that the interaction between ABS and PVC made PVC pyrolysis earlier and HCl emission slightly accelerated. The mixing of ABS and PA6 made their decomposition temperature closer, and ketones in PA6 pyrolysis products were reduced. The presence of ABS made PC pyrolysis earlier, and phenyl compounds in PC pyrolysis products could be transferred into alcohol or H O. The interaction between ABS and other polymers in pyrolysis could be attributed to the intermolecular radical transfer, and free radicals from the polymer firstly decomposed led to a fast initiation the decomposition of the other polymer. As plastic filler, CaCO promoted the thermal decomposition of PA6 and PC, and had no obvious effects on ABS and PVC pyrolysis process. Also, CaCO made the pyrolysis products from PA6 and PC further decomposed into small-molecule compounds like CO . The kinetics analysis showed that isoconversional method like Starink method was more suitable for these polymer blends. Starink method showed the average activation energy of ABS50/PVC50, ABS50/PA50 and ABS50/PC50 was 186.63kJ/mol, 239.61kJ/mol and 248.95kJ/mol, respectively, and the interaction among them could be reflected by the activation energy variation.
[Mh] Termos MeSH primário: Acrilonitrila/química
Automóveis
Butadienos/química
Plásticos/química
Estireno/química
Gerenciamento de Resíduos/métodos
[Mh] Termos MeSH secundário: Carbonato de Cálcio/química
Plásticos/análise
Espectroscopia de Infravermelho com Transformada de Fourier
Termogravimetria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butadienes); 0 (Plastics); 44LJ2U959V (Styrene); H0G9379FGK (Calcium Carbonate); MP1U0D42PE (Acrylonitrile)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170206
[St] Status:MEDLINE


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[PMID]:28115142
[Au] Autor:Guo B; Yu H; Gao B; Zhang S; Yue Q; Xu X
[Ad] Endereço:Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Jinan 250100, China. Electronic address: guobo751119@163.com.
[Ti] Título:Novel cationic polyamidine: Synthesis, characterization, and sludge dewatering performance.
[So] Source:J Environ Sci (China);51:305-314, 2017 Jan.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this study, a new and facile route was employed for synthesis of polyamidine with abundant cations and attractive five-membered ringlike structural unit. N-vinylformamide and acrylonitrile copolymerized firstly to form intermediates, and the intermediates were processed with hydrochloric acid to produce polyamidine. A series of polymerization conditions (e.g. polymerization time, temperature and dosage of initiator) were optimized through productivity, viscosity and cationic degree as evaluation. SEM analysis illustrated that the amidinization process could reduce the size of spaces between molecular and created compact structure, which would contribute to good flocculation performance and high viscosity. FT-IR, XPS and NMR spectra presented a rather clear structure of polyamidine. 34.3% of sludge was sedimentated through the flocculation of polyamidine in the early stages. In contrast, only 6.8% of sludge was sedimentated by polyacrylamide. The moisture content in dehydrated floc could be reduced to 77.7% when 60mg/L polyamidine was added. These results demonstrated that the polyamidine showed a great potential in the practical application of sludge dewatering.
[Mh] Termos MeSH primário: Esgotos/química
Eliminação de Resíduos Líquidos/métodos
[Mh] Termos MeSH secundário: Acrilonitrila/química
Cátions
Dessecação/métodos
Floculação
Polimerização
Polímeros
Espectroscopia de Infravermelho com Transformada de Fourier
Viscosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cations); 0 (Polymers); 0 (Sewage); MP1U0D42PE (Acrylonitrile)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170209
[Lr] Data última revisão:
170209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE


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[PMID]:28110842
[Au] Autor:Colenbie S; Buylaert W; Stove C; Deschepper E; Vandewoude K; De Smedt T; Bader M; Göen T; Van Nieuwenhuyse A; De Paepe P
[Ad] Endereço:Department of Emergency Medicine, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium. Electronic address: sebastiaan.colenbie@icloud.com.
[Ti] Título:Biomarkers in patients admitted to the emergency department after exposure to acrylonitrile in a major railway incident involving bulk chemical material.
[So] Source:Int J Hyg Environ Health;220(2 Pt A):261-270, 2017 Mar.
[Is] ISSN:1618-131X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A railway incident with victims of exposure to the cyanogenic substance acrylonitrile (ACN). AIMS: We retrospectively (i)built an inventory of the clinical characteristics of individuals admitted to surrounding emergency departments (ED's) and (ii)studied the correlation between N-2-cyanoethylvaline (CEV), a biomarker used in a population study for evaluating exposure to ACN, with lactate and thiocyanate (SCN), biomarkers determined during emergency care. RESULTS: 438 patients from 11 ED's were included and presented with known symptoms of ACN poisoning but also with concern about the risks. A comparison of CEV with lactate or SCN was possible in 108 and 73 patients respectively. CEV was very high in a critically ill patient with a high lactate. There was no correlation with CEV in the patients with normal or slightly elevated lactate concentrations. A correlation of CEV with SCN was only observed in smokers. LIMITATIONS: First there is a lack of data in some clinical files concerning the time and duration of exposure and the smoking-status. A second limitation is that blood samples for biomarkers were not taken systematically in all patients, which may have induced bias. A third limitation is that blood sampling was possibly done outside the correct time window related to the delayed toxicity of ACN. Finally the number of severely-intoxicated patients was low and ACN exposure may not have taken place e.g. in individuals consulting with psychological symptoms. These aspects may have contributed to the below detection limits' analyses of biomarkers. CONCLUSIONS: CEV was markedly elevated in a severely-intoxicated patient with high lactate, a sensitive marker for CN intoxication. We found no correlation of CEV with normal or slightly elevated lactate concentrations but clinicians should consider the possibility of subsequent rises due to the delay in ACN toxicity. CEV correlated with SCN in smokers, which may be explained by ACN in tobacco smoke and deserves further exploration. Further studies are necessary to evaluate the correlation between biomarkers in acute chemical exposures to ACN and these should be carried out prospectively using a preplanned template.
[Mh] Termos MeSH primário: Acrilonitrila/envenenamento
Vazamento de Resíduos Químicos
Valina/análogos & derivados
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Bélgica
Biomarcadores/sangue
Criança
Pré-Escolar
Serviço Hospitalar de Emergência
Monitoramento Ambiental
Feminino
Seres Humanos
Lactente
Ácido Láctico/sangue
Masculino
Meia-Idade
Ferrovias
Fumar/sangue
Tiocianatos/sangue
Valina/sangue
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (N-(2-cyanoethyl)valine); 0 (Thiocyanates); 302-04-5 (thiocyanate); 33X04XA5AT (Lactic Acid); HG18B9YRS7 (Valine); MP1U0D42PE (Acrylonitrile)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170124
[St] Status:MEDLINE


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[PMID]:28089400
[Au] Autor:Mallampati SR; Lee BH; Mitoma Y; Simion C
[Ad] Endereço:Department of Civil and Environmental Engineering, University of Ulsan, Daehak-ro 93, Nam-gu, Ulsan 680-749, Republic of Korea. Electronic address: srireddys@ulsan.ac.kr.
[Ti] Título:Selective sequential separation of ABS/HIPS and PVC from automobile and electronic waste shredder residue by hybrid nano-Fe/Ca/CaO assisted ozonisation process.
[So] Source:Waste Manag;60:428-438, 2017 Feb.
[Is] ISSN:1879-2456
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The separation of plastics containing brominated flame retardants (BFR) like (acrylonitrile-butadiene-styrene (ABS), high-impact polystyrene (HIPS), and polyvinyl chloride (PVC)) from automobile and electronic waste shredder residue (ASR/ESR) are a major concern for thermal recycling. In laboratory scale tests using a hybrid nano-Fe/Ca/CaO assisted ozonation treatment has been found to selectively hydrophilize the surface of ABS/HIPS and PVC plastics, enhancing ABS wettability and thereby promoting its separation from ASR/ESR by means of froth flotation. The water contact angles, of ABS/HIPS and PVC decreased, about 18.7°, 18.3°, and 17.9° in ASR and about 21.2°, 20.7°, and 20.0° in ESR respectively. SEM-EDS, FT-IR, and XPS analyses demonstrated a marked decrease in [Cl] and a significant increase in the number of hydrophilic groups, such as CO, CO, and (CO)O, on the PVC or ABS surface. Under froth flotation conditions at 50rpm, about 99.1% of combined fraction of ABS/HIPS in ASR samples and 99.6% of ABS/HIPS in ESR samples were separated as settled fraction. After separation, the purity of the recovered combined ABS/HIPS fraction was 96.5% and 97.6% in ASR and ESR samples respectively. Furthermore, at 150rpm a 100% PVC separation in the settled fraction, with 98% and 99% purity in ASR and ESR plastics, respectively. Total recovery of non-ABS/HIPS and PVC plastics reached nearly 100% in the floating fraction. Further, this process improved the quality of recycled ASR/ESR plastics by removing surface contaminants or impurities.
[Mh] Termos MeSH primário: Automóveis
Resíduo Eletrônico
Ozônio/química
Reciclagem/métodos
[Mh] Termos MeSH secundário: Acrilonitrila
Butadienos
Cálcio/química
Compostos de Cálcio/química
Interações Hidrofóbicas e Hidrofílicas
Ferro/química
Nanotecnologia/métodos
Óxidos/química
Poliestirenos
Cloreto de Polivinila
Eliminação de Resíduos/métodos
Espectroscopia de Infravermelho com Transformada de Fourier
Resíduos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butadienes); 0 (Calcium Compounds); 0 (Oxides); 0 (Polystyrenes); 0 (Waste Products); 66H7ZZK23N (Ozone); 9002-86-2 (Polyvinyl Chloride); C7X2M0VVNH (lime); E1UOL152H7 (Iron); JSD5FGP5VD (1,3-butadiene); MP1U0D42PE (Acrylonitrile); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE



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