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[PMID]:28393463
[Au] Autor:Liu C; Li X; Yang H; Mao X; Wang J; Gao W
[Ad] Endereço:Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, China.
[Ti] Título:Effect of Natural ß-Glucosidase Inhibitors in Reducing Toxicity of Amygdalin in Persicae Semen.
[So] Source:Phytother Res;31(5):771-777, 2017 May.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Amygdalin can be decomposed into hydrocyanic acid, which is the primary source of Persicae Semen toxicity, by gut flora. Here, the inhibitory activity of ß-glucosidase for test herb extracts was first determined and compared. In turn, optimization of the ratio of substrate and inhibitor in vitro and LD values of extracts, serum and liver contents of amygdalin in vivo was measured. Lycii Cortex was found to be the best inhibitory activity for ß-glucosidase. The ratio of amygdalin-to-Lycii Cortex extract of 7.19:8.18 (mmol L /mg mL ) can be relatively suitable for inhibiting ß-glucosidase activity in test in vitro reaction system. After mixed with Lycii Cortex extract, the toxicity of Persicae Semen ethanol extract in mice is significantly reduced and more amygdalin can be absorbed into the bloodstream. The study provides useful information for reducing toxicity of Persicae Semen and suggests how to better use these natural ß-glucosidase inhibitors in the utilization of glycosides and aglycones. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Amigdalina/toxicidade
Alimentos/toxicidade
beta-Glucosidase/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Análise de Alimentos
Masculino
Camundongos
Sementes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
214UUQ9N0H (Amygdalin); EC 3.2.1.21 (beta-Glucosidase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5798


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[PMID]:28146364
[Au] Autor:Todorova A; Pesheva M; Iliev I; Bardarov K; Todorova T
[Ad] Endereço:1 Sofia University "St. Kliment Ohridski ," Faculty of Biology, Sofia, Bulgaria .
[Ti] Título:Antimutagenic, Antirecombinogenic, and Antitumor Effect of Amygdalin in a Yeast Cell-Based Test and Mammalian Cell Lines.
[So] Source:J Med Food;20(4):360-366, 2017 Apr.
[Is] ISSN:1557-7600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Amygdalin is a major component of the seeds of Rosaceae family of plants such as apricots, peaches, cherry, nectarines, apples, plums, and so on, as well as almonds. It is used in alternative medicine for cancer prevention, alleviation of fever, cough suppression, and quenching thirst. The aim of the present study is to determine the mutagenic and recombinogenic effects of amygdalin in a test system Saccharomyces cerevisiae and to evaluate its potential antitumor effect in a yeast cell-based test and colon cancer cell lines. Results obtained show that concentrations 25, 50, and 100 µg/mL did not have any cytotoxic, mutagenic, and carcinogenic effect in yeast cell-based tests. Pretreatment with amygdalin at concentration 100 µg/mL leads to around twofold of the cell survival and decrease of reverse mutation frequency, induced by the alkylating agent methyl methanesulfonate. The frequency of gene conversion and mitotic crossing-over is around threefold lower. The anticarcinogenic potential of amygdalin at the same concentration is presented as around fourfold reduction of Ty1 retrotransposition induced by hexavalent chromium. In summary, data presented in this study provide evidence concerning the inability of amygdalin itself to provoke events related to the initial steps of tumorigenesis. In addition, the observed antimutagenic/antirecombinogenic effect could be activation of error-free and error-prone recombination events. Based on the high selectivity toward normal or tumor cell lines, it could be speculated that amygdalin has higher cytotoxic effect in cell lines with higher proliferative and metabolic activity, which are the majority of fast developing tumors.
[Mh] Termos MeSH primário: Amigdalina/química
Antimutagênicos/farmacologia
Antineoplásicos/farmacologia
Saccharomyces cerevisiae/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Células 3T3 BALB
Proliferação Celular
Sobrevivência Celular
Fibroblastos/efeitos dos fármacos
Células HT29
Células Hep G2
Seres Humanos
Camundongos
Testes de Mutagenicidade
Mutagênicos/farmacologia
Recombinação Genética
Rosaceae/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimutagenic Agents); 0 (Antineoplastic Agents); 0 (Mutagens); 214UUQ9N0H (Amygdalin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.1089/jmf.2016.0108


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[PMID]:27998066
[Au] Autor:Shim YY; Olivia CM; Liu J; Boonen R; Shen J; Reaney MJ
[Ad] Endereço:Prairie Tide Chemicals Inc. , 102 Melville Street, Saskatoon, Saskatchewan S7J 0R1, Canada.
[Ti] Título:Secoisolariciresinol Diglucoside and Cyanogenic Glycosides in Gluten-free Bread Fortified with Flaxseed Meal.
[So] Source:J Agric Food Chem;64(50):9551-9558, 2016 Dec 21.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Flaxseed (Linum usitatissimum L.) meal contains cyanogenic glycosides (CGs) and the lignan secoisolariciresinol diglucoside (1). Gluten-free (GF) doughs and baked goods were produced with added flaxseed meal (20%, w/w) then 1, and CGs were determined in fortified flour, dough, and bread with storage (0, 1, 2, and 4 weeks) at different temperatures (-18, 4, and 22-23 °C). 1 was present in flour, dough, and GF bread after baking. 1 was stable with extensive storage (up to 4 weeks) and was not affected by storage temperature. CGs in flaxseed meal and fortified GF samples were analyzed by H NMR of the cyanohydrins. Linamarin and/or linustatin were the primary CGs in both flaxseed meal and fortified flour. CGs decreased with storage in dough fortified with flaxseed meal or GF bread after baking. GF bakery food products fortified with flaxseed meal had reduced CGs but remained a good source of dietary 1.
[Mh] Termos MeSH primário: Pão/análise
Butileno Glicóis/química
Linho/química
Alimentos Fortificados
Glucosídeos/química
Glicosídeos/química
[Mh] Termos MeSH secundário: Amigdalina/análogos & derivados
Amigdalina/química
Cromatografia Líquida de Alta Pressão
Farinha
Glutens/análise
Lignanas/química
Espectroscopia de Ressonância Magnética
Nitrilos/química
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butylene Glycols); 0 (Glucosides); 0 (Glycosides); 0 (Lignans); 0 (Nitriles); 0 (cyanogenic glycosides); 214UUQ9N0H (Amygdalin); 72229-40-4 (linustatin); 8002-80-0 (Glutens); H3V9RP3WLO (linamarin); T9281L29MV (secoisolariciresinol diglucoside)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b03962


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[PMID]:27853076
[Au] Autor:Iida Y; Takano Y; Ishiwatari Y; Yoshida A; Shimizu T; Ito R; Hattori T; Takahashi N; Hashimoto S
[Ad] Endereço:Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Japan.
[Ti] Título:Diffuse Alveolar Hemorrhage Associated with Makyo-kanseki-to Administration.
[So] Source:Intern Med;55(22):3321-3323, 2016.
[Is] ISSN:1349-7235
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:We herein describe the first known case of diffuse alveolar hemorrhage (DAH) associated with the administration of Makyo-kanseki-to, a Chinese herbal drug. A 64-year-old man with bronchial asthma presented with persistent cough. Makyo-kanseki-to was prescribed as an adjunctive treatment for bronchial asthma. Immediately after drug ingestion, the patient expectorated bloody sputum. DAH was diagnosed based on the presence of bilateral ground-glass opacity which was identified on chest computed tomography and bloody bronchoalveolar lavage fluid. We diagnosed that the administration of Makyo-kanseki-to was the responsible medication because the hemorrhage developed immediately after drug ingestion and resolved after the cessation of such medication with no subsequent recurrence.
[Mh] Termos MeSH primário: Amigdalina/efeitos adversos
Asma/tratamento farmacológico
Medicamentos de Ervas Chinesas/efeitos adversos
Ephedra/efeitos adversos
Hemoptise/induzido quimicamente
[Mh] Termos MeSH secundário: Líquido da Lavagem Broncoalveolar
Seres Humanos
Masculino
Meia-Idade
Alvéolos Pulmonares
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (makyokansekito); 214UUQ9N0H (Amygdalin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161118
[St] Status:MEDLINE


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[PMID]:27400480
[Au] Autor:Kong H; Qu H; Qu B; Zeng W; Zhao Y; Wang X; Wang Q
[Ti] Título:Correlation between the transdermal characteristics of pseudoephedrine and amygdalin in majiepingchuan in vitro.
[So] Source:J Tradit Chin Med;36(2):238-42, 2016 Apr.
[Is] ISSN:0255-2922
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To analyze the transdermal profile of pseudoephedrine and amygdalin in the Traditional Chinese Medicine majiepingchuan in rat skin and to reveal their interaction. METHODS: A Franz diffusion cell was used in vitro to evaluate the transdermal parameters of cumulative transdermal flux (Q(tot)), cumulative transmission (T(tot)), and mean penetration rate (Kp) of pseudoephedrine and amygdalin in majiepingchuan. Linear regression analyses of Q(tot) over time of pseudoephedrine vs amygdalin and their ratios was adopted for correlation evaluation. RESULTS: At 1, 2, 4, 6, and 8 h, the Q(tot), T(tot) and Kp of pseudoephedrine showed a good correlation with that of amygdalin. CONCLUSION: There was a small difference in the ratios of Q(tot), T(tot) and Kp between pseudoephedrine and amygdalin, and a correlation between them.
[Mh] Termos MeSH primário: Amigdalina/farmacocinética
Medicamentos de Ervas Chinesas/farmacocinética
Pseudoefedrina/farmacocinética
[Mh] Termos MeSH secundário: Administração Cutânea
Amigdalina/administração & dosagem
Animais
Medicamentos de Ervas Chinesas/administração & dosagem
Masculino
Pseudoefedrina/administração & dosagem
Ratos
Ratos Sprague-Dawley
Pele/química
Pele/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 214UUQ9N0H (Amygdalin); 7CUC9DDI9F (Pseudoephedrine)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161020
[Lr] Data última revisão:
161020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160713
[St] Status:MEDLINE


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[PMID]:27133300
[Au] Autor:Li XM; Peng JH; Sun ZL; Tian HJ; Duan XH; Liu L; Ma X; Feng Q; Liu P; Hu YY
[Ad] Endereço:Institute of Liver diseases, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
[Ti] Título:Chinese medicine CGA formula ameliorates DMN-induced liver fibrosis in rats via inhibiting MMP2/9, TIMP1/2 and the TGF-ß/Smad signaling pathways.
[So] Source:Acta Pharmacol Sin;37(6):783-93, 2016 Jun.
[Is] ISSN:1745-7254
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIM: Chinese medicine CGA formula consists of polysaccharide from Cordyceps sinensis mycelia (CS-PS), gypenosides and amygdalin, which is derived from Fuzheng Huayu (FZHY) capsule for treating liver fibrosis. In this study we attempted to confirm the therapeutic effects of CGA formula in dimethylnitrosamine (DMN)-induced liver fibrosis in rats, and to identify the mechanisms of anti-fibrotic actions. METHODS: Rats were injected with DMN (10 mg·kg(-1)·d(-1), ip) for 3 consecutive days per week over a 4-week period. The rats then were orally administered with CGA formula (CS-PS 60 mg·kg(-1)·d(-1), gypenosides 50 mg·kg(-1)·d(-1) and amygdalin 80 mg·kg(-1)·d(-1)) daily in the next 2 weeks. CS-PS, gypenosides or amygdalin alone were administered as individual component controls, whereas colchicine and FZHY were used as positive controls. Serum biomarkers were measured. Hepatic injury, collagen deposition and stellate cell activation were examined. The MMP activities, expression of TIMP protein and proteins involved in the TGF-ß1/Smad signaling pathways in liver tissues were assayed. RESULTS: In DMN-treated rats, administration of CGA formula significantly decreased serum ALT, AST and total bilirubin and hepatic hydroxyproline levels, increased serum albumin level, and attenuated liver fibrosis as shown by histological examination. Furthermore, these effects were comparable to those caused by administration of FZHY, and superior to those caused by administration of colchicine or the individual components of CGA formula. Moreover, administration of CGA formula significantly decreased the protein levels of α-SMA, TGF-ß1, TGF-ß1 receptor (TßR-I), p-TßR-I, p-TßR-II, p-Smad2, p-Smad3, TIMP1 and TIMP2, as well as MMP2 and MMP9 activities in liver tissues of DMN-treated rats. CONCLUSION: Chinese medicine CGA formula ameliorates DMN-induced liver fibrosis in rats, and this effect was likely associated with the down-regulation of MMP2/9 activities, TIMP1/2 protein expression and the TGF-ß1/Smad signaling pathways in the liver.
[Mh] Termos MeSH primário: Amigdalina/uso terapêutico
Medicamentos de Ervas Chinesas/uso terapêutico
Cirrose Hepática/tratamento farmacológico
Fígado/efeitos dos fármacos
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Amigdalina/química
Animais
Cordyceps/química
Dimetilnitrosamina
Medicamentos de Ervas Chinesas/química
Gynostemma/química
Fígado/metabolismo
Fígado/patologia
Cirrose Hepática/induzido quimicamente
Cirrose Hepática/patologia
Masculino
Metaloproteinase 2 da Matriz/metabolismo
Metaloproteinase 9 da Matriz/metabolismo
Extratos Vegetais/química
Extratos Vegetais/uso terapêutico
Ratos
Ratos Wistar
Proteínas Smad/metabolismo
Inibidor Tecidual de Metaloproteinase-1/metabolismo
Inibidor Tecidual de Metaloproteinase-2/metabolismo
Fator de Crescimento Transformador beta/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Plant Extracts); 0 (Smad Proteins); 0 (Tissue Inhibitor of Metalloproteinase-1); 0 (Transforming Growth Factor beta); 0 (fuzheng huayu); 0 (gypenoside); 127497-59-0 (Tissue Inhibitor of Metalloproteinase-2); 214UUQ9N0H (Amygdalin); EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.35 (Matrix Metalloproteinase 9); M43H21IO8R (Dimethylnitrosamine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170221
[Lr] Data última revisão:
170221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160503
[St] Status:MEDLINE
[do] DOI:10.1038/aps.2016.35


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[PMID]:27119432
[Au] Autor:Mora CA; Halter JG; Adler C; Hund A; Anders H; Yu K; Stark WJ
[Ad] Endereço:ETH Zurich, Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering , Vladimir-Prelog-Weg 1, 8093 Zurich, Switzerland.
[Ti] Título:Application of the Prunus spp. Cyanide Seed Defense System onto Wheat: Reduced Insect Feeding and Field Growth Tests.
[So] Source:J Agric Food Chem;64(18):3501-7, 2016 May 11.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Many crops are ill-protected against insect pests during storage. To protect cereal grains from herbivores during storage, pesticides are often applied. While pesticides have an undoubtable functionality, increasing concerns are arising about their application. In the present study, we investigated a bioinspired cyanogenic grain coating with amygdalin as cyanogenic precursor mimicking the feeding-triggered release of hydrogen cyanide (HCN) found for example in bitter almonds. The multilayer coating consisted of biodegradable polylactic acid with individual layers containing amygdalin or ß-glucosidase which is capable of degrading amygdalin to HCN. This reaction occurred only when the layers were ruptured, e.g., by a herbivore attack. Upon feeding coated cyanogenic wheat grains to Tenebrio molitor (mealworm beetle), Rhizopertha dominica (lesser grain borer), and Plodia interpunctella (Indianmeal moth), their reproduction as well as consumption rate were significantly reduced, whereas germination ability increased compared to noncoated grains. In field experiments, we observed an initial growth delay compared to uncoated grains which became negligible at later growth stages. The here shown strategy to artificially apply a naturally occurring defense mechanisms could be expanded to other crops than wheat and has the potential to replace certain pesticides with the benefit of complete biodegradability and increased safety during storage.
[Mh] Termos MeSH primário: Coleópteros/efeitos dos fármacos
Cianeto de Hidrogênio/farmacologia
Mariposas/efeitos dos fármacos
Extratos Vegetais/farmacologia
Prunus/química
Triticum/parasitologia
[Mh] Termos MeSH secundário: Amigdalina/farmacologia
Animais
Coleópteros/fisiologia
Comportamento Alimentar/efeitos dos fármacos
Germinação/efeitos dos fármacos
Mariposas/fisiologia
Sementes/química
Sementes/crescimento & desenvolvimento
Sementes/parasitologia
Triticum/química
Triticum/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 214UUQ9N0H (Amygdalin); 2WTB3V159F (Hydrogen Cyanide)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160428
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b00438


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[PMID]:27021084
[Au] Autor:Yamshanov VA; Kovan'ko EG; Pustovalov YI
[Ad] Endereço:Russian Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia. yamshanov@mail.ru.
[Ti] Título:Effects of Amygdaline from Apricot Kernel on Transplanted Tumors in Mice.
[So] Source:Bull Exp Biol Med;160(5):712-4, 2016 Mar.
[Is] ISSN:1573-8221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The effects of amygdaline from apricot kernel added to fodder on the growth of transplanted LYO-1 and Ehrlich carcinoma were studied in mice. Apricot kernels inhibited the growth of both tumors. Apricot kernels, raw and after thermal processing, given 2 days before transplantation produced a pronounced antitumor effect. Heat-processed apricot kernels given in 3 days after transplantation modified the tumor growth and prolonged animal lifespan. Thermal treatment did not considerably reduce the antitumor effect of apricot kernels. It was hypothesized that the antitumor effect of amygdaline on Ehrlich carcinoma and LYO-1 lymphosarcoma was associated with the presence of bacterial genome in the tumor.
[Mh] Termos MeSH primário: Amigdalina/uso terapêutico
Antineoplásicos Fitogênicos/uso terapêutico
Carcinoma de Ehrlich/tratamento farmacológico
Linfoma não Hodgkin/tratamento farmacológico
Prunus armeniaca/metabolismo
[Mh] Termos MeSH secundário: Animais
Camundongos
Transplante de Neoplasias
Preparações de Plantas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Preparations); 214UUQ9N0H (Amygdalin)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170110
[Lr] Data última revisão:
170110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160330
[St] Status:MEDLINE
[do] DOI:10.1007/s10517-016-3257-x


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[PMID]:27002407
[Au] Autor:Blaheta RA; Nelson K; Haferkamp A; Juengel E
[Ad] Endereço:Department of Urology, Goethe-University, Building 25A, Room 404, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany. Electronic address: blaheta@em.uni-frankfurt.de.
[Ti] Título:Amygdalin, quackery or cure?
[So] Source:Phytomedicine;23(4):367-76, 2016 Apr 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The cyanogenic diglucoside, amygdalin, has gained high popularity among cancer patients together with, or in place of, conventional therapy. Still, evidence based research on amygdalin is sparse and its benefit controversial. PURPOSE: Since so many cancer patients consume amygdalin, and many clinicians administer it without clear knowledge of its mode of action, current knowledge has been summarized and the pros and cons of its use weighed. METHODS: A retrospective analysis was conducted for amygdalin relevant reports using the PubMed database with the main search term "Amygdalin" or "laetrile", at times combined with "cancer", "patient", "cyanide" or "toxic". We did not exclude any "unwanted" articles. Additionally, internet sources authorized by governmental or national institutions have also been included. SECTIONS: Individual chapters summarize pharmacokinetics, preclinical and clinical studies and toxicity. CONCLUSION: No convincing evidence showing that amygdalin induces rapid, distinct tumor regression in cancer patients, particularly in those with late-stage disease, is apparent. However, there is also no evidence that purified amygdalin, administered in "therapeutic" dosage, causes toxicity. Multiple aspects of amygdalin administration have not yet been adequately explored, making further investigation necessary to evaluate its actual therapeutic potential.
[Mh] Termos MeSH primário: Amigdalina/uso terapêutico
Antineoplásicos Fitogênicos/uso terapêutico
Cianetos/uso terapêutico
Neoplasias/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
Rosaceae/química
[Mh] Termos MeSH secundário: Amigdalina/efeitos adversos
Antineoplásicos Fitogênicos/efeitos adversos
Cianetos/efeitos adversos
Seres Humanos
Extratos Vegetais/efeitos adversos
Charlatanismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Cyanides); 0 (Plant Extracts); 214UUQ9N0H (Amygdalin)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160323
[St] Status:MEDLINE


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[PMID]:26827990
[Au] Autor:Makarevic J; Tsaur I; Juengel E; Borgmann H; Nelson K; Thomas C; Bartsch G; Haferkamp A; Blaheta RA
[Ad] Endereço:Department of Urology, Goethe-University, Frankfurt am Main, Germany.
[Ti] Título:Amygdalin delays cell cycle progression and blocks growth of prostate cancer cells in vitro.
[So] Source:Life Sci;147:137-42, 2016 Feb 15.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: Despite impressive survival benefits from new agents to treat metastasized prostate cancer (PCa), progressive drug resistance hinders long-term response and restricts the efficacy of subsequent therapy. Due to reported antitumor activity of amygdalin and growing popularity for complementary and alternative medicine the potential of this natural, widely used substance to exert antineoplastic effects on prostate cancer cells has been assessed. MAIN METHODS: LNCaP (castration-sensitive), DU-145 and PC3 cells (castration-resistant) were exposed to different concentrations of amygdalin for 24h or 2weeks. Cell growth was measured by the MTT test, clonal formation by the clonogenic assay. Flow cytometry served to investigate apoptosis and cell cycle phases. Cell cycle regulating proteins and the mTOR-akt signaling axis were analyzed by western blotting. KEY FINDINGS: Amygdalin dose-dependently diminished tumor cell growth with maximum effects at 10mg/ml. Apoptosis of PC3 and LNCaP but not of DU-145 cells was reduced, whereas colony formation was suppressed in all cell lines. A decrease in the number of G2/M- and S-phase cells along with an elevated number of G0/G1-phase cells was recorded. The cell cycle proteins cdk 1, cdk 2 and cdk 4 as well as cyclin A, cyclin B and cyclin D3 were modulated by amygdalin after both 24h and 2weeks. Distinct effects on p19 and p27 expression and on Akt, Rictor and Raptor activation became evident only after 2weeks. SIGNIFICANCE: Amygdalin exhibits significant antitumor activity in both castration-sensitive and castration-resistant PCa cell lines and merits further evaluation for therapeutic purposes.
[Mh] Termos MeSH primário: Amigdalina/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Neoplasias de Próstata Resistentes à Castração/tratamento farmacológico
Neoplasias da Próstata/tratamento farmacológico
[Mh] Termos MeSH secundário: Amigdalina/administração & dosagem
Antineoplásicos Fitogênicos/administração & dosagem
Western Blotting
Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Relação Dose-Resposta a Droga
Citometria de Fluxo
Seres Humanos
Masculino
Neoplasias da Próstata/patologia
Neoplasias de Próstata Resistentes à Castração/patologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 214UUQ9N0H (Amygdalin)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160222
[Lr] Data última revisão:
160222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160202
[St] Status:MEDLINE



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