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[PMID]:28832488
[Au] Autor:Committee on Obstetric Practice
[Ti] Título:Committee Opinion No. 717: Sulfonamides, Nitrofurantoin, and Risk of Birth Defects.
[So] Source:Obstet Gynecol;130(3):e150-e152, 2017 09.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The evidence regarding an association between the nitrofuran and sulfonamide classes of antibiotics and birth defects is mixed. As with all patients, antibiotics should be prescribed for pregnant women only for appropriate indications and for the shortest effective duration. During the second and third trimesters, sulfonamides and nitrofurantoins may continue to be used as first-line agents for the treatment and prevention of urinary tract infections and other infections caused by susceptible organisms. Prescribing sulfonamides or nitrofurantoin in the first trimester is still considered appropriate when no other suitable alternative antibiotics are available. Pregnant women should not be denied appropriate treatment for infections because untreated infections can commonly lead to serious maternal and fetal complications.
[Mh] Termos MeSH primário: Anormalidades Induzidas por Medicamentos/epidemiologia
Anti-Infecciosos Urinários/efeitos adversos
Deformidades Congênitas dos Membros/epidemiologia
Nitrofurantoína/efeitos adversos
Sulfonamidas/efeitos adversos
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Deformidades Congênitas dos Membros/induzido quimicamente
Obstetrícia
Gravidez
Fatores de Risco
Sociedades Médicas
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Urinary); 0 (Sulfonamides); 927AH8112L (Nitrofurantoin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000002300


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[PMID]:28832479
[Ti] Título:Committee Opinion No. 717 Summary: Sulfonamides, Nitrofurantoin, and Risk of Birth Defects.
[So] Source:Obstet Gynecol;130(3):666-667, 2017 Sep.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The evidence regarding an association between the nitrofuran and sulfonamide classes of antibiotics and birth defects is mixed. As with all patients, antibiotics should be prescribed for pregnant women only for appropriate indications and for the shortest effective duration. During the second and third trimesters, sulfonamides and nitrofurantoins may continue to be used as first-line agents for the treatment and prevention of urinary tract infections and other infections caused by susceptible organisms. Prescribing sulfonamides or nitrofurantoin in the first trimester is still considered appropriate when no other suitable alternative antibiotics are available. Pregnant women should not be denied appropriate treatment for infections because untreated infections can commonly lead to serious maternal and fetal complications.
[Mh] Termos MeSH primário: Anormalidades Induzidas por Medicamentos/epidemiologia
Anti-Infecciosos Urinários/efeitos adversos
Deformidades Congênitas dos Membros/epidemiologia
Nitrofurantoína/efeitos adversos
Sulfonamidas/efeitos adversos
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Deformidades Congênitas dos Membros/induzido quimicamente
Obstetrícia
Gravidez
Fatores de Risco
Sociedades Médicas
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Urinary); 0 (Sulfonamides); 927AH8112L (Nitrofurantoin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000002290


  3 / 2163 MEDLINE  
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[PMID]:28819490
[Au] Autor:Izuchukwu KE; Oranu EO; Bassey G; Orazulike NC
[Ad] Endereço:Department of Obstetrics and Gynaecology, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, Nigeria.
[Ti] Título:Maternofetal outcome of asymptomatic bacteriuria among pregnant women in a Nigerian Teaching Hospital.
[So] Source:Pan Afr Med J;27:69, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Asymptomatic bacteriuria has been reported to be associated with adverse pregnancy outcome. This study sought to determine the prevalence and complications of asymptomatic bacteriuria amongst parturient in the University of Port Harcourt Teaching Hospital (UPTH). METHODS: The study was a prospective cohort study involving 220 eligible antenatal attendees. Urine culture and sensitivity was conducted for each participant and the fetomaternal outcome between affected and unaffected women were compared and p value <0.05 was considered significant. RESULTS: Sixty-five of the participants had asymptomatic bacteriuria giving a prevalence of 29.5%. Twenty-three (35.4%) cultures yielded while Fifty-eight (89%) of the cultured organisms were sensitive to Nitrofurantoin. There was no statistical difference in the rate of prelabour rupture of membranes, preeclampsia, preterm delivery, birth asphyxia and low birth weight between affected and unaffected women. CONCLUSION: Contrary to widely held view, there was no significant increase in adverse pregnancy outcome amongst affected women.
[Mh] Termos MeSH primário: Infecções Assintomáticas/epidemiologia
Bacteriúria/epidemiologia
Complicações Infecciosas na Gravidez/epidemiologia
Resultado da Gravidez
[Mh] Termos MeSH secundário: Adulto
Antibacterianos/farmacologia
Bactérias/efeitos dos fármacos
Bactérias/isolamento & purificação
Bacteriúria/complicações
Estudos de Coortes
Feminino
Hospitais de Ensino
Seres Humanos
Recém-Nascido
Testes de Sensibilidade Microbiana
Nigéria/epidemiologia
Nitrofurantoína/farmacologia
Gravidez
Complicações Infecciosas na Gravidez/microbiologia
Estudos Prospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 927AH8112L (Nitrofurantoin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.69.10492


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Brandão, Marcos Antonio Fernandes
[PMID]:28557789
[Au] Autor:Ferreira AO; Polonini HC; Loures da Silva S; Cerqueira de Melo VA; de Andrade L; Brandão MAF
[Ad] Endereço:Ortofarma-Quality Control Laboratories, Matias Barbosa, MG, Brazil. anderson@ortofarma.
[Ti] Título:Stability of Alprazolam, Atropine Sulfate, Glutamine, Levofloxacin, Metoprolol Tartrate, Nitrofurantoin, Ondansetron Hydrochloride, Oxandrolone, Pregabaline, and Riboflavin in SyrSpend SF pH4 Oral Suspensions.
[So] Source:Int J Pharm Compd;21(3):255-263, 2017 May-Jun.
[Is] ISSN:1092-4221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to evaluate the stability of 10 commonly used active pharmaceutical ingredients compounded in oral suspensions using an internationally used suspending vehicle (SyrSpend SF PH4): alprazolam 1.0 mg/mL, atropine sulfate 0.1 mg/mL, glutamine 250.0 mg/mL, levofloxacin 50.0 mg/mL, metoprolol tartrate 10.0 mg/mL, nitrofurantoin 2.0 mg/mL, ondansetron hydrochloride 0.8 mg/mL, oxandrolone 3.0 mg/mL, pregabaline 20.0 mg/mL, riboflavin 10.0 mg/mL. All suspensions were stored at both controlled refrigeration (2°C to 8°C) and controlled room temperature (20°C to 25°C). Stability was assessed by measuring the percent recovery at varying time points throughout a 90-day period. Active pharmaceutical ingredients quantification was performed by high-performance liquid chromatography via a stability-indicating method. Given the percentage of recovery of the active pharmaceutical ingredients within the suspensions, the beyond-use date of the final products (active pharmaceutical ingredients + vehicle) was at least 90 days for all suspensions with regard to both temperatures. This suggests that the vehicle is stable for compounding active pharmaceutical ingredients from different pharmacological classes.
[Mh] Termos MeSH primário: Preparações Farmacêuticas/química
Suspensões/química
[Mh] Termos MeSH secundário: Alprazolam/química
Atropina/química
Composição de Medicamentos/métodos
Estabilidade de Medicamentos
Armazenamento de Medicamentos/métodos
Glutamina/química
Levofloxacino/química
Metoprolol/química
Nitrofurantoína/química
Ondansetron/química
Oxandrolona/química
Pregabalina/química
Refrigeração/métodos
Riboflavina/química
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pharmaceutical Preparations); 0 (Suspensions); 0RH81L854J (Glutamine); 4AF302ESOS (Ondansetron); 55JG375S6M (Pregabalin); 6GNT3Y5LMF (Levofloxacin); 7C0697DR9I (Atropine); 7H6TM3CT4L (Oxandrolone); 927AH8112L (Nitrofurantoin); GEB06NHM23 (Metoprolol); TLM2976OFR (Riboflavin); YU55MQ3IZY (Alprazolam)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE


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[PMID]:28432369
[Au] Autor:Mortazavi SMJ; Zarei S; Taheri M; Tajbakhsh S; Mortazavi SA; Ranjbar S; Momeni F; Masoomi S; Ansari L; Movahedi MM; Taeb S; Zarei S; Haghani M
[Ad] Endereço:Department of Diagnostic Imaging, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA. mmortazavi@sums.ac.ir.
[Ti] Título:Sensitivity to Antibiotics of Bacteria Exposed to Gamma Radiation Emitted from Hot Soils of the High Background Radiation Areas of Ramsar, Northern Iran.
[So] Source:Int J Occup Environ Med;8(2):80-84, 2017 04.
[Is] ISSN:2008-6814
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Over the past several years our laboratories have investigated different aspects of the challenging issue of the alterations in bacterial susceptibility to antibiotics induced by physical stresses. OBJECTIVE: To explore the bacterial susceptibility to antibiotics in samples of subsp. serovar Typhimurium ( ), , and after exposure to gamma radiation emitted from the soil samples taken from the high background radiation areas of Ramsar, northern Iran. METHODS: Standard Kirby-Bauer test, which evaluates the size of the zone of inhibition as an indicator of the susceptibility of different bacteria to antibiotics, was used in this study. RESULTS: The maximum alteration of the diameter of inhibition zone was found for when tested for ciprofloxacin. In this case, the mean diameter of no growth zone in non-irradiated control samples of was 20.3 (SD 0.6) mm; it was 14.7 (SD 0.6) mm in irradiated samples. On the other hand, the minimum changes in the diameter of inhibition zone were found for and when these bacteria were tested for nitrofurantoin and cephalexin, respectively. CONCLUSION: Gamma rays were capable of making significant alterations in bacterial susceptibility to antibiotics. It can be hypothesized that high levels of natural background radiation can induce adaptive phenomena that help microorganisms better cope with lethal effects of antibiotics.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Farmacorresistência Bacteriana/efeitos da radiação
Raios gama
Klebsiella pneumoniae/efeitos dos fármacos
Salmonella typhimurium/efeitos dos fármacos
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Radiação de Fundo
Cefalexina/farmacologia
Ciprofloxacino/farmacologia
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Irã (Geográfico)
Klebsiella pneumoniae/efeitos da radiação
Nitrofurantoína/farmacologia
Salmonella typhimurium/efeitos da radiação
Solo
Staphylococcus aureus/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Soil); 5E8K9I0O4U (Ciprofloxacin); 927AH8112L (Nitrofurantoin); OBN7UDS42Y (Cephalexin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170423
[St] Status:MEDLINE
[do] DOI:10.15171/ijoem.2017.958


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[PMID]:28412931
[Au] Autor:Abdissa R; Haile W; Fite AT; Beyi AF; Agga GE; Edao BM; Tadesse F; Korsa MG; Beyene T; Beyene TJ; De Zutter L; Cox E; Goddeeris BM
[Ad] Endereço:College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu, Oromia, Ethiopia.
[Ti] Título:Prevalence of Escherichia coli O157:H7 in beef cattle at slaughter and beef carcasses at retail shops in Ethiopia.
[So] Source:BMC Infect Dis;17(1):277, 2017 Apr 17.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There is paucity of information regarding the epidemiology of Escherichia coli O157: H7 in developing countries. In this study, we investigated the occurrence of E. coli O157: H7 associated with beef cattle at processing plants and at retail shops in Ethiopia. METHODS: Various samples were collected from beef cattle at slaughter/processing plants, carcass at retail shops and humans at health centers. E. coli O157: H7 was isolated, identified and characterized for antimicrobial resistance, using standard microbiological methods. RESULTS: At the processing plants E. coli O157: H7 was detected in 1.89% of fecal, 0.81% of intestinal mucosal swab, 0.54% of skin swab and 0.54% of carcass internal swab samples. At retail shops it was detected in 0.8% of carcass and 0.8% of cutting board swab samples, while all samples from utensils, hands from workers, and fecal and stool samples were negative. All isolates were resistant to Amoxicillin, moderately resistant to Cefoxitine and Nitrofurantoins but susceptible to other antimicrobials tested. CONCLUSIONS: E. coli O157: H7 occurs at low prevalence in beef cattle, and the current sanitary dressing procedures in the processing plants and storage conditions in the retail shops are effective against E. coli O157: H7.
[Mh] Termos MeSH primário: Matadouros
Escherichia coli O157/isolamento & purificação
Microbiologia de Alimentos/estatística & dados numéricos
Carne Vermelha/microbiologia
[Mh] Termos MeSH secundário: Amoxicilina/farmacologia
Animais
Anti-Infecciosos/farmacologia
Bovinos
Doenças dos Bovinos/epidemiologia
Doenças dos Bovinos/microbiologia
Utensílios de Alimentação e Culinária
Farmacorresistência Bacteriana
Infecções por Escherichia coli/epidemiologia
Infecções por Escherichia coli/microbiologia
Infecções por Escherichia coli/veterinária
Escherichia coli O157/efeitos dos fármacos
Etiópia/epidemiologia
Fezes/microbiologia
Mãos/microbiologia
Seres Humanos
Nitrofurantoína/farmacologia
Prevalência
Pele/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 804826J2HU (Amoxicillin); 927AH8112L (Nitrofurantoin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2372-2


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[PMID]:28410918
[Au] Autor:Grodin L; Conigliaro A; Lee SY; Rose M; Sinert R
[Ad] Endereço:Department of Emergency Medicine, Kings County Hospital Center & SUNY Downstate Medical Center, 451 Clarkson Avenue, Brooklyn, NY 11203-2012, United States.
[Ti] Título:Comparison of UTI antibiograms stratified by ED patient  disposition.
[So] Source:Am J Emerg Med;35(9):1269-1275, 2017 Sep.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Institutional antibiograms guide Emergency Department (ED) clinicians' empiric antibiotic selection. For this study, we created and compared antibiograms of ED patients stratified by disposition (admitted or discharged). METHODS: We conducted a cross-sectional study at two hospitals for 2014, comparing antibiograms limited to Escherichia coli urinary tract infections. Study-Specific Antibiograms, created for the study, excluded polymicrobial samples and multiple cultures from the same patient. Study-Specific Antibiograms were arranged by patient disposition: admitted (IP-Only) vs discharged from the ED (ED-Only). Antibiogram data were presented as average antibiotic sensitivities with 95% confidence intervals and demographic data as medians with interquartile ranges. Sensitivities between Study-Specific Antibiograms were compared by Fisher's Exact Test, alpha=0.05, 2 tails. RESULTS: For Hospital A, 13 antibiotics were compared between Study-Specific ED-Only (n=313) vs IP-Only (n=244). We found that sensitivities to all four antibiotics appropriate for empiric outpatient therapy by Infectious Disease Society of America guidelines were significantly (p<0.0001) higher in the ED-Only compared to IP-Only groups: ciprofloxacin 80% (76-90%) vs 60% (53-69%), levofloxacin 81% (77-91%) vs 63% (57-72%), nitrofurantoin 75% (70-84%) vs 51% (44-58%), and trimethoprim/sulfamethoxazole 73% (68-82%) vs 58% (52-67%). For Hospital B, 14 antibiotics were compared between Study-Specific ED-Only (n=256) and IP-Only (n=168). Two out of the five appropriate empiric outpatient antibiotics had significantly (p<0.0001) higher sensitivities for ED-Only compared to IP-Only: ciprofloxacin 87% (83-91%) vs 71% (64-78%) and levofloxacin 86% (82-91%) vs 71% (65-78%). CONCLUSIONS: We found higher antibiotic sensitivities in ED-Only than the IP-Only Study-Specific Antibiograms. Our Study-Specific Antibiograms offer an alternative guide for antibiotic selection in the ED.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Farmacorresistência Bacteriana
Serviço Hospitalar de Emergência
Infecções por Escherichia coli/tratamento farmacológico
Testes de Sensibilidade Microbiana
Infecções Urinárias/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Idoso
Ciprofloxacino/uso terapêutico
Estudos Transversais
Escherichia coli/efeitos dos fármacos
Feminino
Seres Humanos
Levofloxacino/uso terapêutico
Masculino
Meia-Idade
Nitrofurantoína/uso terapêutico
Combinação Trimetoprima e Sulfametoxazol/uso terapêutico
Estados Unidos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 5E8K9I0O4U (Ciprofloxacin); 6GNT3Y5LMF (Levofloxacin); 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination); 927AH8112L (Nitrofurantoin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170416
[St] Status:MEDLINE


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[PMID]:28400019
[Au] Autor:Calayag AM; Paclibare PA; Santos PD; Bautista CA; Rivera WL
[Ad] Endereço:Institute of Biology, College of Science, University of the Philippines, Diliman, Quezon City, 1101, Philippines; Natural Sciences Research Institute, University of the Philippines, Diliman, Quezon City, 1101, Philippines.
[Ti] Título:Molecular characterization and antimicrobial resistance of Salmonella enterica from swine slaughtered in two different types of Philippine abattoir.
[So] Source:Food Microbiol;65:51-56, 2017 Aug.
[Is] ISSN:1095-9998
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Salmonella enterica is a well-known pathogen commonly acquired from the consumption of contaminated food. It has been estimated to affect millions of humans and cause hundreds of thousands of deaths per year globally. Pork, one of the most commonly consumed meats worldwide, has been identified as one of the main sources of human salmonellosis. In this study, we aimed to detect and characterize S. enterica from slaughtered swine and generate antimicrobial resistance profiles of select isolates. Tonsils and jejunum with mesenteric lymph nodes (MLN) were collected from a total of 240 swine from eight abattoirs (five accredited and three locally registered abattoirs) across Metro Manila. S. enterica were isolated using conventional culture methods and confirmed by PCR amplification of the invA gene. Isolates were further characterized based on somatic antigen by multiplex PCR. We report that there is no significant difference (P = 0.42) between the incidences of S. enterica in swine slaughtered in accredited (44.0%) and in locally registered abattoirs (46.7%). Most samples were contaminated with S. enterica under serogroup O:3,10. Antimicrobial susceptibility testing of 183 isolates using the VITEK 2 system revealed high resistance to ampicillin (67.8%) and trimethoprim/sulfamethoxazole (80.3%). Multidrug-resistance was found in 124 (67.8%) isolates.
[Mh] Termos MeSH primário: Matadouros
Antibacterianos/farmacologia
Carne Vermelha/microbiologia
Salmonella enterica/efeitos dos fármacos
Salmonella enterica/genética
Doenças dos Suínos/microbiologia
[Mh] Termos MeSH secundário: Ampicilina/farmacologia
Animais
Farmacorresistência Bacteriana Múltipla
Microbiologia de Alimentos
Seres Humanos
Jejuno/microbiologia
Testes de Sensibilidade Microbiana
Nitrofurantoína/farmacologia
Tonsila Palatina/microbiologia
Filipinas/epidemiologia
Salmonelose Animal/epidemiologia
Salmonelose Animal/microbiologia
Salmonella enterica/isolamento & purificação
Sorogrupo
Suínos
Doenças dos Suínos/epidemiologia
Combinação Trimetoprima e Sulfametoxazol/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 7C782967RD (Ampicillin); 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination); 927AH8112L (Nitrofurantoin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170427
[Lr] Data última revisão:
170427
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE


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[PMID]:28306135
[Au] Autor:Claussen K; Stocks E; Bhat D; Fish J; Rubin CD
[Ad] Endereço:Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
[Ti] Título:How Common Are Pulmonary and Hepatic Adverse Effects in Older Adults Prescribed Nitrofurantoin?
[So] Source:J Am Geriatr Soc;65(6):1316-1320, 2017 Jun.
[Is] ISSN:1532-5415
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To determine the frequency of serious pulmonary and hepatic adverse events (AEs) in persons aged 65 and older prescribed nitrofurantoin. DESIGN: Retrospective electronic health record (EHR) audit of nitrofurantoin prescriptions and associated AEs. SETTING: Urban academic medical center. PARTICIPANTS: All inpatients and outpatients aged 65 and older prescribed nitrofurantoin from January 1, 2010, to December 31, 2014. MEASUREMENTS: The number of nitrofurantoin prescriptions and pulmonary and hepatic AEs associated with nitrofurantoin use was acquired by data extraction from EHRs. RESULTS: Of 3,400 individuals aged 65 and older prescribed nitrofurantoin during the study period, 641 were identified as possibly having one of five targeted symptoms or disease complications (pulmonary and hepatic) associated with nitrofurantoin. After a detailed chart audit, 89% were deemed to have no adverse reaction, 7% had a minor side effect or allergy, and 3.9% met criteria for suspicion of a nitrofurantoin-induced AE, five of whom were rated as being highly suspicious for nitrofurantoin toxicity; four of the five were identified with pulmonary toxicity and one with hepatotoxicity. Four of five of these individuals used nitrofurantoin chronically. CONCLUSION: Nitrofurantoin was prescribed for 3,400 individuals aged 65 and older during the 5-year study period. Serious side effects appeared to be uncommon, but chronic use appeared to be at greater risk.
[Mh] Termos MeSH primário: Anti-Infecciosos Urinários/efeitos adversos
Doença Hepática Induzida por Substâncias e Drogas
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Pneumopatias/induzido quimicamente
Nitrofurantoína/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Anti-Infecciosos Urinários/uso terapêutico
Registros Eletrônicos de Saúde/utilização
Feminino
Seres Humanos
Doença Iatrogênica
Masculino
Nitrofurantoína/uso terapêutico
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Urinary); 927AH8112L (Nitrofurantoin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.1111/jgs.14796


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[PMID]:28081719
[Au] Autor:Zegers SH; Dieleman J; van der Bruggen T; Kimpen J; de Jong-de Vos van Steenwijk C; Zegers B
[Ad] Endereço:Máxima Medical Center, Post box 7777, 5500 MB, Veldhoven, The Netherlands.
[Ti] Título:The influence of antibiotic prophylaxis on bacterial resistance in urinary tract infections in children with spina bifida.
[So] Source:BMC Infect Dis;17(1):63, 2017 Jan 12.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Bacterial resistance to antibiotics is an increasingly threatening consequence of antimicrobial exposure for many decades now. In urinary tract infections (UTIs), antibiotic prophylaxis (AP) increases bacterial resistance. We studied the resistance patterns of positive urinary cultures in spina bifida children on clean intermittent catheterization, both continuing and stopping AP. METHODS: In a cohort of 176 spina bifida patients, 88 continued and 88 stopped using AP. During 18 months, a fortnightly catheterized urine sample for bacterial pathogens was cultured. UTIs and significant bacteriuria (SBU) were defined as a positive culture with a single species of bacteria, respectively with and without clinical symptoms and leukocyturia. We compared the percentage of resistance to commonly used antibiotics in the isolated bacteria in both groups. RESULTS: In a total of 4917 cultures, 713 (14.5%) had a positive monoculture, 54.3% of which were Escherichia coli. In the group stopping AP, the resistance percentage to antibiotics in UTI / SBU bacteria was lower than in the group remaining on AP, even when excluding the administered prophylaxis. CONCLUSION: Stopping antibiotic prophylaxis for urinary tract infections is associated with reduced bacterial resistance to antibiotics in children with spina bifida. TRIAL REGISTRATION: ISRCTN ISRCTN56278131 . Registered 20 December 2005.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Antibioticoprofilaxia
Bacteriúria/prevenção & controle
Desprescrições
Farmacorresistência Bacteriana
Infecções por Escherichia coli/prevenção & controle
Disrafismo Espinal/complicações
Infecções Urinárias/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Aminoglicosídeos/uso terapêutico
Bacteriúria/etiologia
Bacteriúria/microbiologia
Criança
Escherichia coli/isolamento & purificação
Escherichia coli/fisiologia
Infecções por Escherichia coli/etiologia
Infecções por Escherichia coli/microbiologia
Feminino
Fluoroquinolonas/uso terapêutico
Infecções por Bactérias Gram-Negativas/etiologia
Infecções por Bactérias Gram-Negativas/microbiologia
Infecções por Bactérias Gram-Negativas/prevenção & controle
Infecções por Bactérias Gram-Positivas/etiologia
Infecções por Bactérias Gram-Positivas/microbiologia
Infecções por Bactérias Gram-Positivas/prevenção & controle
Seres Humanos
Masculino
Nitrofurantoína/uso terapêutico
Penicilinas/uso terapêutico
Combinação Trimetoprima e Sulfametoxazol/uso terapêutico
Infecções Urinárias/etiologia
Infecções Urinárias/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Aminoglycosides); 0 (Anti-Bacterial Agents); 0 (Fluoroquinolones); 0 (Penicillins); 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination); 927AH8112L (Nitrofurantoin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-016-2166-y



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