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[PMID]:29215338
[Au] Autor:Kart D; Kustimur AS; Sagiroglu M; Kalkanci A
[Ad] Endereço:Department of Pharmaceutical Microbiology, Hacettepe University Faculty of Pharmacy, Ankara, Turkey.
[Ti] Título:Evaluation of Antimicrobial Durability and Anti-Biofilm Effects in Urinary Catheters Against Clinical Isolates and Reference Strains.
[So] Source:Balkan Med J;34(6):546-552, 2017 12 01.
[Is] ISSN:2146-3131
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: and biofilms are major causes of catheter-associated urinary tract infections. Antimicrobial-coated or impregnated urinary catheters are seen as a possible way to prevent these infections. AIMS: To determine the biofilm-forming ability of 89 isolates from urinary tract infections and to compare several urinary catheters for antimicrobial durability and the inhibitory effects on biofilm formation of different laboratory strains and clinical isolates of . STUDY DESIGN: experimental study. METHODS: The biofilm forming ability of isolates was determined by the crystal violet staining and plate counting methods. For comparison of urinary catheters, biofilms of 45 isolates from the catheter samples of hospitalized patients and five laboratory strains of ATCC25922, ATCC35984, ATCC27853, ATCC29212 and ATCC90028 were formed on the catheters in 24-well tissue culture plates. Scanning electron microscopy analysis was performed to observe biofilms. RESULTS: All 89 isolates were found to be biofilm positive. Nitrofurazone-impregnated catheters significantly reduced the cell counts of isolates and completely inhibited the formation of and biofilms compared with the others. Regarding reduction of biofilm cell counts, a hydrophilic-coated catheter was more effective against , whereas a silver-coated catheter was found to be more effective against . The nitrofurazone-impregnated catheter had the best antimicrobial durability. CONCLUSION: Urine isolates of had considerable ability with respect to biofilm formation. The nitrofurazone-impregnated catheter was the most effective against all tested bacteria; however, the effect of a hydrophilic or silver-coated catheter depends on the species present in it.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Biofilmes/efeitos dos fármacos
Infecções Relacionadas a Cateter/microbiologia
Cateteres de Demora/microbiologia
Enterococcus faecalis/efeitos dos fármacos
Nitrofurazona/farmacologia
Infecções Urinárias/microbiologia
[Mh] Termos MeSH secundário: Infecções Relacionadas a Cateter/prevenção & controle
Materiais Revestidos Biocompatíveis
Enterococcus faecalis/isolamento & purificação
Seres Humanos
Técnicas In Vitro
Testes de Sensibilidade Microbiana
Silicones
Prata
Cateterismo Urinário/efeitos adversos
Infecções Urinárias/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Coated Materials, Biocompatible); 0 (Silicones); 3M4G523W1G (Silver); X8XI70B5Z6 (Nitrofurazone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.4274/balkanmedj.2016.1853


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[PMID]:28454918
[Au] Autor:Monteiro LM; Löbenberg R; Ferreira EI; Cotrim PC; Kanashiro E; Rocha M; Chung MC; Bou-Chacra N
[Ad] Endereço:Pharmacy Department, Faculty of Pharmaceutical Sciences, University de São Paulo, São Paulo, Brazil.
[Ti] Título:Targeting Leishmania amazonensis amastigotes through macrophage internalisation of a hydroxymethylnitrofurazone nanostructured polymeric system.
[So] Source:Int J Antimicrob Agents;50(1):88-92, 2017 Jul.
[Is] ISSN:1872-7913
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Dextran-coated poly (n-butyl cyanoacrylate) nanoparticles (PBCA-NPs) were prepared and were evaluated for enhanced delivery of a promising anti-Leishmania drug candidate, hydroxymethylnitrofurazone (NFOH), to phagocytic cells. Currently available chemotherapy for leishmaniasis, such as pentavalent antimonials, presents low safety and efficacy. Furthermore, widespread drug resistance in leishmaniasis is rapidly emerging. To overcome these drawbacks, the use of nanosized delivery systems can reduce systemic drug toxicity and increase the drug concentration in infected macrophages, therefore improving treatment of leishmaniasis. PBCA-NPs containing NFOH (PBCA-NFOH-NPs) were prepared by an anionic emulsion polymerisation method. The z-average and polydispersity index (PDI) were determined by photon correlation spectroscopy, the zeta potential by microelectrophoresis and the entrapment efficiency by HPLC. Cytotoxicity was determined using macrophages from BALB/c mice. Efficacy tests were performed using Leishmania amazonensis promastigotes and amastigotes. The z-average of PBCA-NFOH-NPs was 151.5 ± 61.97 nm, with a PDI of 0.104 ± 0.01, a zeta potential of -10.1 ± 6.49 mV and an entrapment efficiency of 64.47 ± 0.43%. Efficacy in amastigotes revealed IC values of 0.33 µM and 31.2 µM for the nanostructured and free NFOH, respectively (95-fold increase). The cytotoxicity study indicated low toxicity of the PBCA-NFOH-NPs to macrophages. The selectivity index was 370.6, which is 49-fold higher than free NFOH (7.6). Such findings indicated that improved efficacy could be due to NP internalisation following site-specific drug delivery and reactivation of immune protective reactions by the NP components. Thus, PBCA-NFOH-NPs have the potential to significantly improve the treatment of leishmaniasis, with reduced systemic side effects.
[Mh] Termos MeSH primário: Antiprotozoários/metabolismo
Leishmania/efeitos dos fármacos
Macrófagos/parasitologia
Nanopartículas/metabolismo
Nitrofurazona/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Sobrevivência Celular/efeitos dos fármacos
Concentração Inibidora 50
Macrófagos/fisiologia
Camundongos Endogâmicos BALB C
Nanopartículas/toxicidade
Nitrofurazona/metabolismo
Testes de Sensibilidade Parasitária
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (hydroxymethylnitrofurazone); X8XI70B5Z6 (Nitrofurazone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


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[PMID]:28637162
[Au] Autor:Kong D; Yun H; Cui D; Qi M; Shao C; Cui D; Ren N; Liang B; Wang A
[Ad] Endereço:Shenyang Academy of Environmental Sciences, Shenyang 110167, China; State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China.
[Ti] Título:Response of antimicrobial nitrofurazone-degrading biocathode communities to different cathode potentials.
[So] Source:Bioresour Technol;241:951-958, 2017 Oct.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bioelectrodegradation of various organic pollutants has been extensively studied. However, whether different cathode potentials could alter the antimicrobial-degrading biocathode community structure and composition remain poorly understood. Here, the microbial community structure and composition of the nitrofurans nitrofurazone (NFZ) degrading biocathode in response to different cathode potentials (-0.45±0.01, -0.65±0.01 and -0.86±0.05V vs standard hydrogen electrode, with applied cell voltages of 0.2, 0.5 and 0.8V, respectively) were investigated. The bioelectrodegradation efficiency and degree of NFZ were highly related to different cathode potentials. The 0.2 and 0.5V performed biocathode communities were similar but significantly differed from those of the 0.8V and open circuit biofilms. The bacteria possessing functions of nitroaromatics reduction and electrons transfer (e.g. Klebsiella, Enterococcus, Citrobacter and Desulfovibrio) were selectively enriched in different biocathode communities. This study offers new insights into the ecological response of antimicrobial-degrading biocathode communities to different cathode potentials.
[Mh] Termos MeSH primário: Anti-Infecciosos
Bactérias
Fontes de Energia Bioelétrica
Nitrofurazona
[Mh] Termos MeSH secundário: Biofilmes
Eletrodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); X8XI70B5Z6 (Nitrofurazone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE


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[PMID]:28514366
[Au] Autor:Vladimirova TY; Barishevskaya LA; Lyamin AV; Kondratenko OV; Velikanov AK
[Ad] Endereço:Samara State Medical University, Samara, Russia, 443099.
[Ti] Título:[Applicability of antibacterial agents in chronic tonsillitis treatment].
[Ti] Título:Vozmozhnosti primeneniia antibakterial'nykh sredstv pri khronicheskom tonzillite..
[So] Source:Vestn Otorinolaringol;82(2):55-59, 2017.
[Is] ISSN:0042-4668
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The purpose of the present study was to evaluate the effectiveness of nitrofuranes applied for the treatment of chronic tonsillitis. A total of 92 subjects divided into three cohorts were involved in this study. Cohort 1 included 43 patients presenting with decompensated chronic tonsillitis and having pathogens in palatine tonsil lacunae. Cohort 2 was comprised of 13 patients with compensated chronic tonsillitis having pathogenic microflora of the same localization, while Cohort 3 was composed of 36 patients resembling those of cohort 1 in terms of clinical presentation, pathogen composition, and microbial spectrum. While the patients of cohort 1 and cohort 2 were treated by rinsing their tonsil lacunae with a furasol solution as a single-drug therapeutic procedure, those comprising Cohort 3 underwent treatment with furacilinum for the same purpose. The results of the study give evidence of the important advantages of furasol therapy over other modalities for the conservative treatment of chronic tonsillitis.
[Mh] Termos MeSH primário: Furazolidona/administração & dosagem
Nitrofurazona/administração & dosagem
Staphylococcus aureus
Irrigação Terapêutica/métodos
Tonsilite
[Mh] Termos MeSH secundário: Adulto
Antibacterianos/administração & dosagem
Doença Crônica
Tratamento Conservador/métodos
Feminino
Seres Humanos
Masculino
Soluções Farmacêuticas
Índice de Gravidade de Doença
Staphylococcus aureus/efeitos dos fármacos
Staphylococcus aureus/isolamento & purificação
Tonsilite/diagnóstico
Tonsilite/tratamento farmacológico
Tonsilite/microbiologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Pharmaceutical Solutions); 5J9CPU3RE0 (Furazolidone); X8XI70B5Z6 (Nitrofurazone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE
[do] DOI:10.17116/otorino201782255-59


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[PMID]:27496199
[Au] Autor:Özkaya E; Polat Ekinci A
[Ad] Endereço:Department of Dermatology and Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey. profeo@istanbul.edu.tr.
[Ti] Título:Foot contact dermatitis: nitrofurazone as the main cause in a retrospective, cross-sectional study over a 16-year period from Turkey.
[So] Source:Int J Dermatol;55(12):1345-1350, 2016 Dec.
[Is] ISSN:1365-4632
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The major causative agents in allergic contact dermatitis of the foot may differ from country to country. Sufficient data on foot eczema in patients from Turkey are lacking. OBJECTIVE: To identify the clinically relevant contact allergens in foot eczema and determine the role of patch test series and patients' own materials in the detection of the responsible allergens. METHODS: Among 1753 patients patch tested between 1996 and 2012 in our clinic, 53 with suspected allergic foot eczema were enrolled in this retrospective, cross-sectional study. Forty nine patients were patch tested with the extended European baseline series, 49 with supplemental series including rubber, leather, topical drugs, textile, cosmetic series containing preservatives and emulgators and varnish/plastic/glue series, and 37 with their own substances. RESULTS: Thirty of the 53 patch tested patients showing sensitization to at least one clinically relevant allergen were diagnosed with allergic foot eczema. The main eliciting agent was nitrofurazone (n = 8), followed by leather shoe allergens, ie, potassium dichromate (n = 6), p-tert-butylphenol formaldehyde resin and formaldehyde, in the second range. Rubber shoe allergens were less frequently observed (n = 3). In more than 1/3 of the patients, the causative agent could only be identified by testing the patient's own substances and/or supplemental series. CONCLUSION: Nitrofurazone was the leading causative agent followed by leather shoe allergens. Pediatric patients were frequently sensitized with shoe allergens. Patch testing with patient's own substances had a critical value in the detection of the causative agent in a significant number of patients.
[Mh] Termos MeSH primário: Dermatite Alérgica de Contato/etiologia
Dermatoses do Pé/induzido quimicamente
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Anti-Infecciosos/efeitos adversos
Criança
Pré-Escolar
Corantes/efeitos adversos
Estudos Transversais
Erupção por Droga/etiologia
Feminino
Formaldeído/efeitos adversos
Seres Humanos
Masculino
Meia-Idade
Nitrofurazona/efeitos adversos
Testes do Emplastro
Dicromato de Potássio/efeitos adversos
Resinas Sintéticas/efeitos adversos
Estudos Retrospectivos
Turquia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Coloring Agents); 0 (Resins, Synthetic); 1HG84L3525 (Formaldehyde); 25085-50-1 (p-tert-butylphenolformaldehyde resin); T4423S18FM (Potassium Dichromate); X8XI70B5Z6 (Nitrofurazone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160807
[St] Status:MEDLINE
[do] DOI:10.1111/ijd.13384


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[PMID]:27455411
[Au] Autor:Pearson RA; Evans C; Bendall JG
[Ad] Endereço:a AsureQuality Wellington Laboratory , Lower Hutt , New Zealand.
[Ti] Título:Nitrofurazone quantification in milk at the European Union minimum required performance limit of 1 ng g(-1): circumventing the semicarbazide problem.
[So] Source:Food Addit Contam Part A Chem Anal Control Expo Risk Assess;33(8):1324-36, 2016 Aug.
[Is] ISSN:1944-0057
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nitrofurazone is an antibiotic with carcinogenic properties. Efforts by regulatory authorities to control nitrofurazone from agricultural foods are an important public health measure that have, to some extent, been undermined by widespread use amongst laboratories of the unreliable marker metabolite semicarbazide. This work confirms what has long been suspected, namely that powdered dairy products that are initially free of semicarbazide develop semicarbazide under storage conditions such as occur normally across commercial supply chains. The low ng g(-)(1) levels of semicarbazide formed in this way are insufficient to present any food safety hazard. That such development of a marker metabolite is demonstrated to occur by innocent means effectively invalidates the use of semicarbazide as a marker metabolite for powdered dairy products, and exacerbates the regulatory need for a more suitable analytical methodology. In milk, unlike meat, nitrofurazone is known to remain stable and thus available for analysis in the intact form, rather than necessitating any use of a metabolite or fragment. However, no previous methodology that was capable of achieving the stringent European minimum required performance limit of 1 ng g(-)(1) when using intact nitrofurazone had been described for milk. This work describes a specific methodology using LC-MS/MS for milk and milk powder; it achieves detection of intact nitrofurazone (as well as furazolidone, furaltadone and nitrofurantoin) to levels well below 1 ng g(-)(1). Laboratories will no longer need to use semicarbazide as an unreliable marker metabolite for the analysis of nitrofurazone in dairy products, paving the way for regulatory authorities to better control nitrofurazone abuse with greater confidence.
[Mh] Termos MeSH primário: Leite/química
Nitrofurazona/análise
Semicarbazidas/análise
[Mh] Termos MeSH secundário: Animais
União Europeia
Contaminação de Alimentos/análise
Seres Humanos
Semicarbazidas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Semicarbazides); X8XI70B5Z6 (Nitrofurazone)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160726
[St] Status:MEDLINE
[do] DOI:10.1080/19440049.2016.1209692


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[PMID]:27318979
[Au] Autor:Silva FT; Franco CH; Favaro DC; Freitas-Junior LH; Moraes CB; Ferreira EI
[Ad] Endereço:School of Pharmaceutical Sciences, University of São Paulo, Avenida Prof. Lineu Prestes, 580, Bl. 13, São Paulo, São Paulo, Brazil.
[Ti] Título:Design, synthesis and antitrypanosomal activity of some nitrofurazone 1,2,4-triazolic bioisosteric analogues.
[So] Source:Eur J Med Chem;121:553-560, 2016 Oct 04.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Chagas disease, caused by Trypanosoma cruzi, is a parasitosis that predominates in Latin America. It is estimated that 25 million people are under the risk of infection and, in 2008, more than 10 thousand deaths were registered. The only two drugs available in the therapeutics, nifurtimox and benznidazole, showed to be more effective in the acute phase of the disease. However, there is no standard treatment protocol effective for the chronic phase. Nitrofurazone (NF), an antimicrobial drug, has activity against T. cruzi, although being toxic. Considering the need for new antichagasic drugs, the existence of promising new therapeutic targets, as 14α-sterol demethylase and cruzain, and employing the bioisosterism and molecular hybridization approaches, four novel compounds were synthesized, characterized by melting point range, elemental analysis, IR and NMR spectroscopy. The compounds were tested against T. cruzi amastigotes in infected U2OS cells. All compounds showed selectivity towards T. cruzi and showed trypanomicidal activity in low micromolar range. The compound 3 showed potency similar to benznidazole, but lower efficacy. These results highlight the importance of the 1,2,4-triazole, thiosemicarbazonic and nitro group moieties for designing new efficient compounds, potentially for the chronic phase of Chagas disease.
[Mh] Termos MeSH primário: Nitrofurazona/síntese química
Nitrofurazona/farmacologia
Triazóis/química
Tripanossomicidas/síntese química
Tripanossomicidas/farmacologia
Trypanosoma cruzi/efeitos dos fármacos
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Técnicas de Química Sintética
Seres Humanos
Hidrazonas/química
Modelos Moleculares
Conformação Molecular
Nitrofurazona/química
Tripanossomicidas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrazones); 0 (Triazoles); 0 (Trypanocidal Agents); 288-88-0 (1,2,4-triazole); X8XI70B5Z6 (Nitrofurazone)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160620
[St] Status:MEDLINE


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[PMID]:27105976
[Au] Autor:Ciftci Z; Kurc MA; Kaya AD; Saracoglu GV; Deniz M; Gultekin E
[Ad] Endereço:Namik Kemal University, School of Medicine, Department of Otorhinolaryngology.
[Ti] Título:Do we really need to coat the novel silicone intranasal splints with antibiotics?
[So] Source:Am J Otolaryngol;37(5):447-51, 2016 Sep-Oct.
[Is] ISSN:1532-818X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The novel silicone intranasal splints are suggested to resist biofilm formation due to their surface characteristics. We aimed to ascertain the necessity of coating these splints with antibiotics to prevent splint associated infections, in vitro. MATERIALS AND METHODS: Pieces of Doyle II airway nasal splints made of medical grade silicone were divided into two test groups, treated with either (i) 0.2% nitrofurazone solution or (ii) 0.2% nitrofurazone containing ointment, and a control group, treated with (iii) 0.9% saline. Splint pieces were then incubated with Staphylococcus aureus solutions at 37°C for 48 and 96h. Following this, the splint pieces were incubated in 20ml Mueller Hinton agar and appearing colonies were counted. RESULTS: Following 48and 96h of incubation, the colonization rates in the saline group were significantly higher than the nitrofurazone ointment group (p<0.001). The colonization rates in the liquid nitrofurazone group were significantly lower in comparison to the nitrofurazone ointment group (p<0.001 and p=0.019 respectively). CONCLUSIONS: The method of coating the splints with antibiotic was superior to using uncoated splints in terms of preventing S. aureus colonization. The rather smooth surfaces of the splints were insufficient to block bacterial colonization and coating them with antibiotics seems to be beneficial for the prevention of infections.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Biofilmes/efeitos dos fármacos
Nitrofurazona/administração & dosagem
Silicones
Contenções/microbiologia
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Biofilmes/crescimento & desenvolvimento
Contagem de Colônia Microbiana
Staphylococcus aureus/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Silicones); X8XI70B5Z6 (Nitrofurazone)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160424
[St] Status:MEDLINE


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[PMID]:27048728
[Au] Autor:Pogoda D; Janczak J; Videnova-Adrabinska V
[Ad] Endereço:Department of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, Wroclaw 50-370, Poland.
[Ti] Título:New polymorphs of an old drug: conformational and synthon polymorphism of 5-nitrofurazone.
[So] Source:Acta Crystallogr B Struct Sci Cryst Eng Mater;72(Pt 2):263-73, 2016 Apr.
[Is] ISSN:2052-5206
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new polymorphic forms of 5-nitrofurazone (5-nitro-2-furaldehyde semicarbazone) have been synthesized and structurally characterized by single-crystal and powder X-ray diffraction methods, vibrational spectroscopy (FT-IR and temperature Raman), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and Hirshfeld surface analysis. The compound crystallizes in three different polymorphic forms P21/a (polymorph α), P21 (polymorph ß) and P21/c (polymorph γ), the crystal structures of two of which (polymorphs ß and γ) represent new structure determinations. The solid-state molecular organization in the three crystal forms is analyzed and discussed in terms of molecular conformation, crystal packing and hydrogen-bonded networks. All three crystals are formed from trans geometrical isomers, but the molecular conformation of the α-polymorph is syn-anti-anti-anti, while that of ß- and γ-polymorphs is syn-anti-syn-syn. As a consequence of this the hydrogen-bond donor and acceptor sites of the molecules are oriented differently, which in turn results in different hydrogen-bond connectivity and packing patterns.
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Nitrofurazona/química
[Mh] Termos MeSH secundário: Anti-Infecciosos/síntese química
Cristalografia por Raios X
Modelos Moleculares
Conformação Molecular
Nitrofurazona/síntese química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); X8XI70B5Z6 (Nitrofurazone)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160407
[St] Status:MEDLINE
[do] DOI:10.1107/S2052520615024956


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[PMID]:26985968
[Au] Autor:Wang Y; Chan W
[Ad] Endereço:Department of Chemistry, The Hong Kong University of Science and Technology , Clear Water Bay, Kowloon, Hong Kong.
[Ti] Título:Automated In-Injector Derivatization Combined with High-Performance Liquid Chromatography-Fluorescence Detection for the Determination of Semicarbazide in Fish and Bread Samples.
[So] Source:J Agric Food Chem;64(13):2802-8, 2016 Apr 06.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Semicarbazide (1) is a widespread genotoxic food contaminant originating as a metabolic byproduct of the antibiotic nitrofurazone used in fish farming or as a thermal degradation product of the common flour additive azodicarbonamide. The goal of this study is to develop a simple and sensitive high-performance liquid chromatography coupled with fluorescence detection (HPLC-FLD) method for the detection of compound 1 in food products. In comparison to existing methods for the determination of compound 1, the reported method combining online precolumn derivatization and HPLC-FLD is less labor-intensive, produces higher sample throughput, and does not require the use of expensive analytical instruments. After validation of accuracy and precision, this method was applied to determine the amount of compound 1 in fish and bread samples. Comparative studies using an established liquid chromatography coupled with tandem mass spectrometry method did not yield systematically different results, indicating that the developed HPLC-FLD method is accurate and suitable for the determination of compound 1 in fish and bread samples.
[Mh] Termos MeSH primário: Pão/análise
Cromatografia Líquida de Alta Pressão/métodos
Peixes
Farinha/análise
Semicarbazidas/análise
[Mh] Termos MeSH secundário: Animais
Compostos Azo/metabolismo
Nitrofurazona/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Azo Compounds); 0 (Semicarbazides); 37QUC23K2X (carbamylhydrazine); 56Z28B9C8O (1,1-azobisformamide); X8XI70B5Z6 (Nitrofurazone)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160318
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b00651



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