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[PMID]:28412947
[Au] Autor:Hora AS; Miyashiro SI; Cassiano FC; Brandão PE; Reche-Junior A; Pena HFJ
[Ad] Endereço:Department of Preventive Veterinary Medicine and Animal Health, College of Veterinary Medicine, University of São Paulo, São Paulo, SP, Brazil. alineshora@gmail.com.
[Ti] Título:Report of the first clinical case of intestinal trichomoniasis caused by Tritrichomonas foetus in a cat with chronic diarrhoea in Brazil.
[So] Source:BMC Vet Res;13(1):109, 2017 Apr 17.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Tritrichomonas foetus is an emergent and important enteric pathogen of cats, which causes prolonged diarrhoea in cats. CASE PRESENTATION: This study describes a T. foetus infection in a seven-month-old, entire male domestic shorthair kitten with a six-month history of persistent large intestinal diarrhoea, faecal incontinence, prostration, apathy and weight loss. Parasites were microscopically observed and confirmed by PCR and DNA sequencing. Molecular analyses were carried out comparing the sequence obtained in this study with T. foetus and T. suis. Retrieved from GenBank. After treatment with ronidazole, the cat showed resolution of clinical signs. CONCLUSIONS: This is the first clinical case of T. foetus infection in a chronic diarrheic cat in Brazil and South America, confirming the presence of this pathogen in this part of the world and highlighting the importance of this protozoa being considered in the differential diagnosis of cats presenting diarrhoea of the large intestine. Our case report enriches our knowledge on the geographical distribution of T. foetus in cats in Brazil and provides further understanding of the clinical significance of feline intestinal trichomoniasis in this country.
[Mh] Termos MeSH primário: Doenças do Gato/parasitologia
Diarreia/veterinária
Infecções Protozoárias em Animais/diagnóstico
Tritrichomonas foetus/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Antiprotozoários/administração & dosagem
Brasil/epidemiologia
Doenças do Gato/tratamento farmacológico
Gatos
DNA de Protozoário/análise
Diarreia/tratamento farmacológico
Diarreia/parasitologia
Masculino
Infecções Protozoárias em Animais/tratamento farmacológico
Ronidazole/administração & dosagem
Tritrichomonas foetus/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (DNA, Protozoan); E01R4M1063 (Ronidazole)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-017-1026-3


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[PMID]:28245739
[Au] Autor:Gookin JL; Hanrahan K; Levy MG
[Ad] Endereço:Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh NC, USA.
[Ti] Título:The conundrum of feline Trichomonosis.
[So] Source:J Feline Med Surg;19(3):261-274, 2017 Mar.
[Is] ISSN:1532-2750
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Practical relevance: Trichomonosis of the large intestine of the cat was described as a cause of chronic diarrhea over 20 years ago. The trichomonad was identified as Tritrichomonas foetus, with a genotype that is distinct from venereal T foetus of cattle. Clinical challenges: Despite multiple means for diagnosis of the infection, including light microscopy, protozoal culture and PCR amplification using species-specific primers, tests with even greater sensitivity are needed. Feline trichomonosis is resistant to all commonly used antiprotozoal drugs. Ronidazole is currently the only drug demonstrated to be effective in eliminating the infection from cats; however, this drug has a narrow safety margin and clinical resistance is increasingly recognized. The more we learn about trichomonosis in cats, the more complicated and controversial the infection has become, ranging from what we should call the organism to whether we should even bother trying to treat it. Global importance: Feline trichomonosis is recognized to occur worldwide and is regarded as one of the most common infectious causes of colitis in the domestic cat. The infection is widespread in catteries and shelters; and, while remission of diarrhea may occur over time, persistence of the infection is common. Evidence base: This review provides a comprehensive examination of what is currently known about feline trichomonosis and pinpoints areas, based on the authors' opinion, where further research is needed.
[Mh] Termos MeSH primário: Doenças do Gato/diagnóstico
Infecções Protozoárias em Animais/diagnóstico
Tritrichomonas foetus/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Antiprotozoários/uso terapêutico
Doenças do Gato/tratamento farmacológico
Doenças do Gato/parasitologia
Gatos
Reação em Cadeia da Polimerase/veterinária
Infecções Protozoárias em Animais/tratamento farmacológico
Infecções Protozoárias em Animais/parasitologia
Ronidazole/uso terapêutico
Tritrichomonas foetus/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; PORTRAITS; REVIEW
[Nm] Nome de substância:
0 (Antiprotozoal Agents); E01R4M1063 (Ronidazole)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1177/1098612X17693499


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[PMID]:27838954
[Au] Autor:Mitrowska K; Antczak M
[Ad] Endereço:a Department of Pharmacology and Toxicology , National Veterinary Research Institute (PIWet) , Pulawy , Poland.
[Ti] Título:Transfer of nitroimidazoles from contaminated beeswax to honey.
[So] Source:Food Addit Contam Part A Chem Anal Control Expo Risk Assess;34(4):573-581, 2017 Apr.
[Is] ISSN:1944-0057
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nitroimidazoles are not authorised for the treatment of honey bees in the European Union. However, they can be found in honey largely because they are illegally used in apiculture for the treatment of Nosema. The aim of the study was to examine the possible transfer of nitroimidazoles (metronidazole, ronidazole, dimetridazole and ipronidazole) from contaminated beeswax to honey. The wax foundations fortified with a mixture of four nitroimidazoles at three concentration levels (1000, 10,000 and 100,000 µg kg ) were placed in beehives to let the honeybees (Apis mellifera L.) draw out the contaminated wax foundations to honeycombs. At 1 month from the start, the frames filled with capped honey were removed from the hives for a first sampling of honey. Next, the honeycombs were further incubated for 5 months in the laboratory at 35°C and sampled monthly. In the sampled honey, the concentrations of nitroimidazoles and their main metabolites (hydroxymetronidazole, 2-hydroxymethyl-1-methyl-5-nitroimidazole, hydroxyipronidazole) were determined by LC-MS/MS and compared with those determined in the nitroimidazole-containing wax foundations. Each of the tested nitroimidazoles could migrate from beeswax to honey kept in the contaminated combs at each tested concentration level. Higher maximum concentrations of residues in honey sampled from contaminated combs at 1000, 10,000 and 100,000 µg kg were observed for metronidazole (28.9, 368.5 and 2589.4 µg kg respectively) and ronidazole (27.4, 232.9 and 2351.2 µg kg respectively), while lower maximum concentrations were measured for dimetridazole (0.98, 8.4 and 67.7 µg kg ) and ipronidazole (0.9, 7.9 and 35.7 µg kg respectively). When we took into account that a frame completely filled with honey on both sides of the comb contained 110 g of beeswax and 2488 g of honey, and that this ratio was constant, then maximum amounts of initial metronidazole, ronidazole, dimetridazole and ipronidazole that migrated from contaminated wax foundations to honey could be calculated: 65-89%, 55-63%, 1.7-2.7% and 1.4-2.3%, respectively.
[Mh] Termos MeSH primário: Antifúngicos/análise
Contaminação de Alimentos/análise
Mel/análise
Drogas Veterinárias/análise
Ceras/química
[Mh] Termos MeSH secundário: Animais
Antifúngicos/administração & dosagem
Antifúngicos/metabolismo
Criação de Abelhas
Abelhas/efeitos dos fármacos
Abelhas/metabolismo
Transporte Biológico
Cromatografia Líquida
Difusão
Dimetridazol/administração & dosagem
Dimetridazol/análise
Dimetridazol/metabolismo
Controle de Medicamentos e Entorpecentes/legislação & jurisprudência
União Europeia
Seres Humanos
Ipronidazol/administração & dosagem
Ipronidazol/análise
Ipronidazol/metabolismo
Metronidazol/administração & dosagem
Metronidazol/análise
Metronidazol/metabolismo
Ronidazole/administração & dosagem
Ronidazole/análise
Ronidazole/metabolismo
Espectrometria de Massas em Tandem
Drogas Veterinárias/administração & dosagem
Drogas Veterinárias/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Veterinary Drugs); 0 (Waxes); 045BU63E23 (Ipronidazole); 140QMO216E (Metronidazole); 8012-89-3 (beeswax); E01R4M1063 (Ronidazole); K59P7XNB8X (Dimetridazole)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170308
[Lr] Data última revisão:
170308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161115
[St] Status:MEDLINE
[do] DOI:10.1080/19440049.2016.1260166


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[PMID]:26662037
[Au] Autor:Grellet A; Makhlouf SE; Desquilbet L; Hovhannessian F; Boogaerts C; Dore V; Anthony M; Espana B; Prouillac C; Kirilov P; Polack B; Perrot S
[Ad] Endereço:1 Paris East University, National Veterinary School of Alfort, Livestock and Sport Medicine Unit, CHUVA, Maisons-Alfort, France.
[Ti] Título:Efficacy of guar gum-based ronidazole capsules as a treatment for Tritrichomonas foetus infection in cats.
[So] Source:J Feline Med Surg;19(2):177-184, 2017 Feb.
[Is] ISSN:1532-2750
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objectives The aims of the study were to determine the in vitro drug release of guar gum-coated capsules of ronidazole, and to evaluate the pharmacokinetics and efficacy of this formulation for the treatment of cats naturally infected with Tritrichomonas foetus. Methods The pharmacokinetics of ronidazole were evaluated in five healthy cats and five cats infected with T foetus. In a second step, the clinical efficacy of these capsules was evaluated by a controlled, randomised, double-blind clinical trial performed in 47 infected cats from French catteries. In this study, cats were randomly allocated to either the ronidazole treatment group (n = 25) or a placebo group (n = 22). Ronidazole (30 mg/kg) q24h for 14 days was administered to the treated cats. After 14 days of treatment, the presence of T foetus was tested by conventional PCR assay. Results In the pharmacokinetic study, a delayed peak plasma concentration was observed in healthy and infected cats, with no significant difference between these two groups (mean geometric mean of 9 h for time to maximum plasma concentration [T ], 21.6 µg/ml for time to maximum plasma concentration [C ] and 467.4 µg/h/ml for the area under the curve [AUC] in healthy cats; and 9.4 h for T , 17.1 µg/ml for C and 481 µg/h/ml for AUC in infected cats). In the clinical trial, T foetus was detected in 16% of cats from the treated group and 82% of cats from the placebo group at the end of the study ( P <0.001). No clinical signs of adverse drug reactions were observed. Conclusions and relevance Oral administration of guar gum-coated capsules of ronidazole at a dose of 30 mg/kg once daily for 14 days delays the peak plasma concentration and eradicates infection in most cases.
[Mh] Termos MeSH primário: Antiprotozoários/administração & dosagem
Doenças do Gato/tratamento farmacológico
Galactanos/administração & dosagem
Mananas/administração & dosagem
Gomas Vegetais/administração & dosagem
Infecções por Protozoários/tratamento farmacológico
Ronidazole/administração & dosagem
Tritrichomonas foetus
[Mh] Termos MeSH secundário: Administração Oral
Animais
Área Sob a Curva
Doenças do Gato/parasitologia
Gatos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Galactans); 0 (Mannans); 0 (Plant Gums); E01R4M1063 (Ronidazole); E89I1637KE (guar gum)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE
[do] DOI:10.1177/1098612X15621353


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[PMID]:27423157
[Au] Autor:Steiner JM; Schwamberger S; Pantchev N; Balzer HJ; Vrhovec MG; Lesina M; Algül H
[Ad] Endereço:Second Department of Internal Medicine, Klinikum rechts der Isar of the Technical University of Munich, Munich, Germany; Gastrointestinal Laboratory, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas, USA. jsteiner@cvm.tamu.edu.
[Ti] Título:Use of Ronidazole and Limited Culling To Eliminate Tritrichomonas muris from Laboratory Mice.
[So] Source:J Am Assoc Lab Anim Sci;55(4):480-3, 2016.
[Is] ISSN:1559-6109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tritrichomonas muris is occasionally identified during routine fecal screening of laboratory mice. Frequently, entire racks are affected, and because no effective treatment is available, culling of affected mice and rederivation by embryo transfer have been suggested. The current study evaluated whether treatment with ronidazole, a nitroimidazole efficacious against T. fetus infections in cats, combined with limited culling was effective against T. muris in laboratory mice (Mus musculus). A subset (n = 39) of mice were treated with ronidazole (400 mg/L in drinking water) for 15 d, after which 6 of the mice still shed T. muris. Consequently all mice in the affected rack received ronidazole (500 mg /L in drinking water) for 25 d. All mice were retested by using pooled samples, and those positive for T. muris (except for a valuable breeding pair) were culled. The remaining mice continued to receive ronidazole for another 17 d. At the end of the treatment period, all mice were tested (days 60 and 81) and were shown to be negative for T. muris. Over the following year, sentinel mice from the rack were tested every 3 mo and remained negative for tritrichomonads by fecal smear. Thus, a combination of limited culling and treatment with ronidazole in the drinking water successfully cleared research mice of infection with T. muris.
[Mh] Termos MeSH primário: Antiprotozoários/administração & dosagem
Infecções Protozoárias em Animais/tratamento farmacológico
Infecções Protozoárias em Animais/prevenção & controle
Doenças dos Roedores/tratamento farmacológico
Doenças dos Roedores/prevenção & controle
Ronidazole/administração & dosagem
Tritrichomonas/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Erradicação de Doenças/métodos
Fezes/parasitologia
Camundongos
Infecções Protozoárias em Animais/parasitologia
Doenças dos Roedores/fisiopatologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); E01R4M1063 (Ronidazole)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170223
[Lr] Data última revisão:
170223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160717
[St] Status:MEDLINE


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[PMID]:26791585
[Au] Autor:Kavianinia I; Plieger PG; Cave NJ; Gopakumar G; Dunowska M; Kandile NG; Harding DR
[Ad] Endereço:Chemistry, Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand.
[Ti] Título:Design and evaluation of a novel chitosan-based system for colon-specific drug delivery.
[So] Source:Int J Biol Macromol;85:539-46, 2016 Apr.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Tritrichomonas foetus is a flagellated protozoan parasite that colonizes the feline colon causing colitis and chronic foul smelling diarrhoea. Despite the efficacy of Ronidazole in the treatment of T. foetus, Ronidazole has been reported to cause neurotoxicity in some cats due to rapid absorption in the small intestine. A novel amphoteric derivative of chitosan was synthesised and characterized. A combination of time, pH, and an enzyme controlled system was used in a study of a new compression coated tablet for delivery of Ronidazole to the colon. Axial, radial swelling and erosion of selected tablets were carried out in various media. The effect of weight ratio, enzyme and pH on in vitro drug release profile was investigated. The results show that less than 2% of the drug was released in the physiological environment of the stomach and small intestine.
[Mh] Termos MeSH primário: Quitosana/química
Colo/efeitos dos fármacos
Portadores de Fármacos/química
Sistemas de Liberação de Medicamentos
Desenho de Drogas
[Mh] Termos MeSH secundário: Animais
Antiprotozoários/administração & dosagem
Linhagem Celular
Liberação Controlada de Fármacos
Concentração de Íons de Hidrogênio
Ronidazole/administração & dosagem
Espectroscopia de Infravermelho com Transformada de Fourier
Comprimidos/química
Temperatura Ambiente
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Drug Carriers); 0 (Tablets); 9012-76-4 (Chitosan); E01R4M1063 (Ronidazole)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160122
[St] Status:MEDLINE


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[PMID]:26591381
[Au] Autor:Reinert J; Gerold S; Scheurlen U; Daniels R; Wolm M; Iglauer F
[Ti] Título:[Treatment of Tritrichomonas foetus in a cat colony with delayed release ronidazole tablets in the small intestine].
[Ti] Título:Behandlung einer an Tritrichomonas foetus erkrankten Katzen-Kolonie mittels Ronidazoltabletten unter verzögerter Wirkstofffreisetzung im Dünndarm..
[So] Source:Berl Munch Tierarztl Wochenschr;128(9-10):362-9, 2015 Sep-Oct.
[Is] ISSN:0005-9366
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:Seven abyssinian cats (two male, five female) showed intermittent green-yellow mucous diarrhoea, sometimes an inflammation of the anal region and faecal incontinence even after long-time treatment with fenbendazole against Giardia. During necropsy of one of the cats, which had to be euthanized due to another disease, the gut wall of small and large intestine appeared macroscopically thickened. Histological examination indicated flagellates in the lumen of the intestine (initiating at the jejunum) and in the crypts. However Giardia could be excluded. in this case. By PCR of the faeces Tritrichomonas (T) foetus was diagnosed in five of six cats of this colony. Five remaining animals (another cat had to be euthanized) were treated with about 30 mg per kg BW ronidazole p. o. (rededication; Ridzol 10% Bt®, Dr. Hesse Tierpharma GmbH & Co. KG, Germany) daily over 14 days. The special gastro-resistant processing of the ronidazole should ensure a targeted effects. Animals were treated consecutively, isolated from the other cats and were daily examined clinically and neurologically. Neurotoxic adverse effects appeared slightly, therefore--as a precaution--the treatment of two cats was paused for one day. After treatment of all cats, T. foetus wasn't diagnosed by PCR over the period of 345 to > 800 days in any cat. One animal had dubious findings in the ninth week after treatment. Hence it was still kept isolated from the group and PCR showed a negative result at all times afterwards. The treatment protocol shows that elimination of problematic protozoal infections is possible in cat colonies.
[Mh] Termos MeSH primário: Antiprotozoários/administração & dosagem
Doenças do Gato/tratamento farmacológico
Intestino Delgado/metabolismo
Infecções Protozoárias em Animais/tratamento farmacológico
Ronidazole/administração & dosagem
Tritrichomonas foetus
[Mh] Termos MeSH secundário: Administração Oral
Animais
Antiprotozoários/farmacocinética
Doenças do Gato/metabolismo
Gatos
Preparações de Ação Retardada
Feminino
Absorção Intestinal
Masculino
Infecções Protozoárias em Animais/metabolismo
Ronidazole/farmacocinética
Comprimidos
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Delayed-Action Preparations); 0 (Tablets); E01R4M1063 (Ronidazole)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:151120
[Lr] Data última revisão:
151120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151124
[St] Status:MEDLINE


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[PMID]:25372355
[Au] Autor:Gadaj A; Cooper KM; Karoonuthaisiri N; Furey A; Danaher M
[Ad] Endereço:a Food Safety Department , Teagasc Food Research Centre , Ashtown, Dublin 15 , Ireland.
[Ti] Título:Determination of the persistence of dimetridazole, metronidazole and ronidazole residues in black tiger shrimp (Penaeus monodon) tissue and their stability during cooking.
[So] Source:Food Addit Contam Part A Chem Anal Control Expo Risk Assess;32(2):180-93, 2015.
[Is] ISSN:1944-0057
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The depletion of three banned nitroimidazole drugs - dimetridazole (DMZ), metronidazole (MNZ) and ronidazole (RNZ) - was investigated in black tiger shrimp (Penaeus monodon) following in-water medication. The highest concentrations of residues were measured immediately after the 24-h immersion (d0). At this time, MNZ and MNZ-OH residues were measured in shrimp tissue samples at concentrations ranging from 361 to 4189 and from 0.28 to 6.6 µg kg(-1), respectively. DMZ and its metabolites HMMNI ranged in concentration between 31,509 and 37,780 and between 15.0 and 31.9 µg kg(-1), respectively. RNZ and HMMNI concentrations ranged from 14,530 to 24,206 and from 25.0 to 55 µg kg(-1), respectively. MNZ, DMZ and RNZ were the more persistent marker residues and can be detected for at least 8 days post-treatment. MNZ-OH was only detectable on d0 following treatment with MNZ. HMMNI residues were only detectable up to d1 (0.97-3.2 µg kg(-1)) or d2 (1.2-4.5 µg kg(-1)) following DMZ and RNZ treatment, respectively. The parent drugs MNZ, DMZ and RNZ were still measureable on d8 at 0.12-1.0, 40.5-55 and 8.8-18.7 µg kg(-1), respectively. The study also investigated the stability of nitroimidazole residues under various cooking procedures (frying, grilling, boiling, and boiling followed by microwaving). The experiments were carried out in shrimp muscle tissue containing both high and low concentrations of these residues. Different cooking procedures showed the impact on nitroimidazole residue concentration in shrimp tissue. Residue concentration depleted significantly, but partially, by boiling and/or microwaving, but the compounds were largely resistant to conventional grilling or frying. Cooking cannot therefore be considered as a safeguard against harmful nitroimidazole residues in shrimp.
[Mh] Termos MeSH primário: Culinária
Dimetridazol/análise
Aditivos Alimentares/análise
Análise de Alimentos
Metronidazol/análise
Penaeidae/química
Ronidazole/análise
[Mh] Termos MeSH secundário: Animais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Food Additives); 140QMO216E (Metronidazole); E01R4M1063 (Ronidazole); K59P7XNB8X (Dimetridazole)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150130
[Lr] Data última revisão:
150130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141106
[St] Status:MEDLINE
[do] DOI:10.1080/19440049.2014.983997


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[PMID]:25141357
[Au] Autor:Qin L; Lin YL; Xu B; Hu CY; Tian FX; Zhang TY; Zhu WQ; Huang H; Gao NY
[Ad] Endereço:State Key Laboratory of Pollution Control and Resources Reuse, Key Laboratory of Yangtze Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, PR China.
[Ti] Título:Kinetic models and pathways of ronidazole degradation by chlorination, UV irradiation and UV/chlorine processes.
[So] Source:Water Res;65:271-81, 2014 Nov 15.
[Is] ISSN:1879-2448
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Degradation kinetics and pathways of ronidazole (RNZ) by chlorination (Cl2), UV irradiation and combined UV/chlorine processes were investigated in this paper. The degradation kinetics of RNZ chlorination followed a second-order behavior with the rate constants calculated as (2.13 ± 0.15) × 10(2) M(-2) s(-1), (0.82 ± 0.52) × 10(-2) M(-1) s(-1) and (2.06 ± 0.09) × 10(-1) M(-1) s(-1) for the acid-catalyzed reaction, as well as the reactions of RNZ with HOCl and OCl(-), respectively. Although UV irradiation degraded RNZ more effectively than chlorination did, very low quantum yield of RNZ at 254 nm was obtained as 1.02 × 10(-3) mol E(-1). RNZ could be efficiently degraded and mineralized in the UV/chlorine process due to the generation of hydroxyl radicals. The second-order rate constant between RNZ and hydroxyl radical was determined as (2.92 ± 0.05) × 10(9) M(-1) s(-1). The degradation intermediates of RNZ during the three processes were identified with Ultra Performance Liquid Chromatography - Electrospray Ionization - mass spectrometry and the degradation pathways were then proposed. Moreover, the variation of chloropicrin (TCNM) and chloroform (CF) formation after the three processes were further evaluated. Enhanced formation of CF and TCNM precursors during UV/chlorine process deserves extensive attention in drinking water treatment.
[Mh] Termos MeSH primário: Cloro/química
Ronidazole/química
Raios Ultravioleta
Poluentes Químicos da Água/química
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Clorofórmio/química
Halogenação
Hidrocarbonetos Clorados/química
Cinética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hydrocarbons, Chlorinated); 0 (Water Pollutants, Chemical); 4R7X1O2820 (Chlorine); 7V31YC746X (Chloroform); E01R4M1063 (Ronidazole); I4JTX7Z7U2 (chloropicrin)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:140916
[Lr] Data última revisão:
140916
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140821
[St] Status:MEDLINE


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[PMID]:25059163
[Au] Autor:Han C; Chen J; Wu X; Huang YW; Zhao Y
[Ad] Endereço:Department of Physics and Astronomy, University of Georgia, USA; Nanoscale Science and Engineering Center, University of Georgia, USA; School of Physics and Electronic Engineering, Jiangsu Normal University, China; Jiangsu Province Key Laboratory of Advanced Laser Materials and Devices, China. Elect
[Ti] Título:Detection of metronidazole and ronidazole from environmental samples by surface enhanced Raman spectroscopy.
[So] Source:Talanta;128:293-8, 2014 Oct.
[Is] ISSN:1873-3573
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this study, the surface enhanced Raman spectra (SERS) of two prohibited veterinary drugs, metronidazole (MNZ) and ronidazole (RNZ), have been acquired, and compared to the theoretically calculated spectra using density function theory (DFT). The experimental Raman and SERS spectra of MNZ and RNZ exhibit high resemblance with the DFT calculations. SERS detection of MNZ and RNZ from standard solutions as well as real environmental samples (tap, lake, swamp waters and soil) was performed on highly sensitive and reproducible silver nanorod array substrates. The limits of detection for MNZ and RNZ are 10 and 1 µg/mL in methanol and ultra-pure water, respectively, and 10-50 µg/mL in the environmental samples. The SERS-based method demonstrates its potential as a rapid, simple, and inexpensive means for the onsite screening of banned antibiotics from the aquatic and sediment environments, with minimal requirement for sample pretreatment.
[Mh] Termos MeSH primário: Metronidazol/análise
Ronidazole/análise
Solo/química
Análise Espectral Raman/métodos
Recursos Hídricos/análise
[Mh] Termos MeSH secundário: Análise Discriminante
Água Potável/análise
Água Potável/química
Monitoramento Ambiental/métodos
Água Doce/análise
Água Doce/química
Lagos/química
Análise dos Mínimos Quadrados
Análise de Componente Principal
Reprodutibilidade dos Testes
Poluentes Químicos da Água/análise
Abastecimento de Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Drinking Water); 0 (Soil); 0 (Water Pollutants, Chemical); 140QMO216E (Metronidazole); E01R4M1063 (Ronidazole)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140726
[St] Status:MEDLINE



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