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  1 / 4801 MEDLINE  
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[PMID]:29232578
[Au] Autor:Lopes SMM; Novais JS; Costa DCS; Castro HC; Figueiredo AMS; Ferreira VF; Pinho E Melo TMVD; da Silva FC
[Ad] Endereço:CQC and Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
[Ti] Título:Hetero-Diels-Alder reactions of novel 3-triazolyl-nitrosoalkenes as an approach to functionalized 1,2,3-triazoles with antibacterial profile.
[So] Source:Eur J Med Chem;143:1010-1020, 2018 Jan 01.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The generation and reactivity of 3-triazolyl-nitrosoalkenes are reported for the first time. The study showed that hetero-Diels-Alder reaction of these heterodienes is an interesting synthetic strategy to functionalized 1,2,3-triazoles, including 1,2,3-triazolyl-pyrroles, 1,2,3-triazolyl-dipyrromethanes and 1,2,3-triazolyl-indoles. The evaluation of the antibacterial profile against Gram-positive and Gram-negative strains revealed the new 5,5'-diethyldipyrromethane bearing a side chain incorporating a triazole and oxime moieties. The antibacterial profile detected was within the Clinical and Laboratory Standard Institute (CLSI) range and against important Staphylococcus species including Methicillin-resistant strain (S. aureus ATCC 25923, S. epidermidis ATCC 12228 and S. simulans ATCC 27851 and MRSA). Interestingly, this new 1,2,3-triazole presented hemocompatibility and low in silico toxicity profile similar to antibiotics current in use. It also has an usual antibiofilm activity against MRSA, which reinforced its potential as a new antibacterial prototype.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Staphylococcus/efeitos dos fármacos
Triazóis/farmacologia
[Mh] Termos MeSH secundário: Alcenos/química
Antibacterianos/síntese química
Antibacterianos/química
Biofilmes/efeitos dos fármacos
Reação de Cicloadição
Relação Dose-Resposta a Droga
Testes de Sensibilidade Microbiana
Estrutura Molecular
Compostos Nitrosos/química
Staphylococcus/crescimento & desenvolvimento
Relação Estrutura-Atividade
Triazóis/síntese química
Triazóis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkenes); 0 (Anti-Bacterial Agents); 0 (Nitroso Compounds); 0 (Triazoles)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE


  2 / 4801 MEDLINE  
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[PMID]:28693087
[Au] Autor:Liang QQ; Zheng WW; He GS; Qu WD
[Ad] Endereço:School of Public Health, Fudan University, Key Laboratory of the Public Health and Safety, Ministry of Education, Shanghai 200032, China.
[Ti] Título:[Quantitative structure-activity relationship prediction of carcinogenicity of N-nitroso compounds based on category approach and read-across].
[So] Source:Zhonghua Yu Fang Yi Xue Za Zhi;51(7):621-627, 2017 Jul 06.
[Is] ISSN:0253-9624
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:New quantitative structure-activity relationship (QSAR) method was used to predict N-nitroso compounds (NOCs) carcinogenicity. This could provide evidences for health risk assessment of the chemicals. Total 74 chemical substances of NOCs were included as target chemicals for this validation study by using QSAR Toolbox based on category approach and read-across. The included 74 NOCs were categorized and subcategorized respectively using "Organic functional groups, Norbert Haider " profiler and "DNA binding by OASIS V.1.1" profiler. Carcinogenicity of rat were used as target of prediction, the carcinogenicity of analogues in chemical categories were cross-read to obtain the carcinogenic predictive results of the target chemicals. Results 74 NOCs included 26 nonclic N-nitrosamines, 24 cyclic N-nitrosamines and 24 N-nitrosamides The sensitivity, specificity and concordance of the category approach and read-across for predicting carcinogenicity of 74 NOCs were 75% (48/64), 70%(7/10) and 74% (55/74) respectively. The concordance for noncyclic N-nitrosamines, cyclic N-nitrosamines and N-nitrosamides were 88% (23/26), 71% (17/24) and 63% (15/24) respectively. QSAR based on category approach and read-across is good for prediction of NOCs carcinogenicity, and can be used for high-throughput qualitative prediction of NOCs carcinogenicity.
[Mh] Termos MeSH primário: Carcinógenos/toxicidade
Compostos Nitrosos/toxicidade
Relação Quantitativa Estrutura-Atividade
[Mh] Termos MeSH secundário: Animais
Testes de Carcinogenicidade
Nitrosaminas
Ratos
Medição de Risco
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinogens); 0 (Nitrosamines); 0 (Nitroso Compounds); 0 (nitrosamides)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0253-9624.2017.07.009


  3 / 4801 MEDLINE  
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[PMID]:28176426
[Au] Autor:Ivanova LV; Cibich D; Deye G; Talipov MR; Timerghazin QK
[Ad] Endereço:Department of Chemistry, Marquette University, 535 N. 14th Street, Milwaukee, WI, 53233, USA.
[Ti] Título:Modeling of S-Nitrosothiol-Thiol Reactions of Biological Significance: HNO Production by S-Thiolation Requires a Proton Shuttle and Stabilization of Polar Intermediates.
[So] Source:Chembiochem;18(8):726-738, 2017 Apr 18.
[Is] ISSN:1439-7633
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Nitroxyl (HNO), a reduced form of the important gasotransmitter nitric oxide, exhibits its own unique biological activity. A possible biological pathway of HNO formation is the S-thiolation reaction between thiols and S-nitrosothiols (RSNOs). Our density functional theory (DFT) calculations suggested that S-thiolation proceeds through a proton transfer from the thiol to the RSNO nitrogen atom, which increases electrophilicity of the RSNO sulfur, followed by nucleophilic attack by thiol, yielding a charge-separated zwitterionic intermediate structure RSS (R)N(H)O (Zi), which decomposes to yield HNO and disulfide RSSR. In the gas phase, the proton transfer and the S-S bond formation are asynchronous, resulting in a high activation barrier (>40 kcal mol ), making the reaction infeasible. However, the barrier can decrease below the S-N bond dissociation energy in RSNOs (≈30 kcal mol ) upon transition into an aqueous environment that stabilizes Zi and provides a proton shuttle to synchronize the proton transfer and the S-S bond formation. These mechanistic features suggest that S-thiolation can easily lend itself to enzymatic catalysis and thus can be a possible route of endogenous HNO production.
[Mh] Termos MeSH primário: Hidrogênio/química
Óxidos de Nitrogênio/síntese química
Compostos Nitrosos/química
Compostos de Sulfidrila/química
[Mh] Termos MeSH secundário: Catálise
Modelos Químicos
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitrogen Oxides); 0 (Nitroso Compounds); 0 (Sulfhydryl Compounds); 059QF0KO0R (Water); 7YNJ3PO35Z (Hydrogen); GFQ4MMS07W (nitroxyl)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1002/cbic.201600556


  4 / 4801 MEDLINE  
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[PMID]:28017778
[Au] Autor:Chen F; Wang Y; Rafikov R; Haigh S; Zhi WB; Kumar S; Doulias PT; Rafikova O; Pillich H; Chakraborty T; Lucas R; Verin AD; Catravas JD; She JX; Black SM; Fulton DJR
[Ad] Endereço:Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu, China; Vascular Biology Center, Augusta University, Augusta, Georgia 30912, USA. Electronic address: fchen@njmu.edu.cn.
[Ti] Título:RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G -bacterial toxins.
[So] Source:Biochem Pharmacol;127:34-45, 2017 Mar 01.
[Is] ISSN:1873-2968
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Disruption of the endothelial barrier in response to Gram positive (G ) bacterial toxins is a major complication of acute lung injury (ALI) and can be further aggravated by antibiotics which stimulate toxin release. The integrity of the pulmonary endothelial barrier is mediated by the balance of disruptive forces such as the small GTPase RhoA, and protective forces including endothelium-derived nitric oxide (NO). How NO protects against the barrier dysfunction is incompletely understood and our goal was to determine whether NO and S-nitrosylation can modulate RhoA activity and whether this mechanism is important for G toxin-induced microvascular permeability. We found that the G toxin listeriolysin-O (LLO) increased RhoA activity and that NO and S-NO donors inhibit RhoA activity. RhoA was robustly S-nitrosylated as determined by biotin-switch and mercury column analysis. MS revealed that three primary cysteine residues are S-nitrosylated including cys16, cys20 and cys159. Mutation of these residues to serine diminished S-nitrosylation to endogenous NO and mutant RhoA was less sensitive to inhibition by S-NO. G -toxins stimulated the denitrosylation of RhoA which was not mediated by S-nitrosoglutathione reductase (GSNOR), thioredoxin (TRX) or thiol-dependent enzyme activity but was instead stimulated directly by elevated calcium levels. Calcium-promoted the direct denitrosylation of WT but not mutant RhoA and mutant RhoA adenovirus was more effective than WT in disrupting the barrier integrity of human lung microvascular endothelial cells. In conclusion, we reveal a novel mechanism by which NO and S-nitrosylation reduces RhoA activity which may be of significance in the management of pulmonary endothelial permeability induced by G -toxins.
[Mh] Termos MeSH primário: Toxinas Bacterianas/farmacologia
Endotélio Vascular/metabolismo
Proteínas de Choque Térmico/farmacologia
Proteínas Hemolisinas/farmacologia
Compostos Nitrosos/metabolismo
Proteína rhoA de Ligação ao GTP/metabolismo
[Mh] Termos MeSH secundário: Animais
Células COS
Cálcio/metabolismo
Cercopithecus aethiops
Células Endoteliais/metabolismo
Células HEK293
Seres Humanos
Pulmão/irrigação sanguínea
Microvasos/metabolismo
Mutação
Óxido Nítrico/metabolismo
Doadores de Óxido Nítrico/farmacologia
Permeabilidade
Proteína rhoA de Ligação ao GTP/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Toxins); 0 (Heat-Shock Proteins); 0 (Hemolysin Proteins); 0 (Nitric Oxide Donors); 0 (Nitroso Compounds); 31C4KY9ESH (Nitric Oxide); 72270-41-8 (hlyA protein, Listeria monocytogenes); EC 3.6.5.2 (rhoA GTP-Binding Protein); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170902
[Lr] Data última revisão:
170902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161227
[St] Status:MEDLINE


  5 / 4801 MEDLINE  
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[PMID]:27913919
[Au] Autor:Jeyakumar A; Dissabandara L; Gopalan V
[Ad] Endereço:School of Medical Science, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, 4222, Australia.
[Ti] Título:A critical overview on the biological and molecular features of red and processed meat in colorectal carcinogenesis.
[So] Source:J Gastroenterol;52(4):407-418, 2017 Apr.
[Is] ISSN:1435-5922
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:A recent investigation by the World Health Organisation (WHO) has found that the consumption of processed meat and potentially red meat promotes carcinogenesis and can increase the risk of colorectal cancer. This literature review aims to summarise both the red and processed meat molecules associated with colorectal carcinogenesis and investigate their relationship with the pathogenic process of colorectal cancer. Literature relating to the carcinogenic effect of red and processed meat molecules was critically reviewed. There are multiple molecules present in red and processed meat with a potential carcinogenic effect on colorectal tissues. Processed meat is more carcinogenic compared to red meat because of the abundance of potent nitrosyl-heme molecules that form N-nitroso compounds. Studies have also noted that other molecules such as polycyclic aromatic hydrocarbons and heterocyclic amines have potential mechanisms for the initiation of colorectal cancer pathogenesis. The non-human sugar molecule N-glycolylneuraminic acid may account for the carcinogenic effects of pork despite its heme content being comparable to that of chicken. Red meat products, especially those that have been processed, have a wide variety of carcinogenic molecules known to increase the risk of colorectal cancer. Thus, the outcome of this review is consistent with the recent findings of WHO.
[Mh] Termos MeSH primário: Carcinogênese
Neoplasias Colorretais/etiologia
Manipulação de Alimentos
Carne/efeitos adversos
[Mh] Termos MeSH secundário: Carcinógenos/análise
Carcinógenos/toxicidade
Heme/efeitos adversos
Seres Humanos
Carne/análise
Produtos da Carne/efeitos adversos
Produtos da Carne/análise
Compostos Nitrosos/efeitos adversos
Carne Vermelha/efeitos adversos
Carne Vermelha/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Carcinogens); 0 (Nitroso Compounds); 42VZT0U6YR (Heme)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161204
[St] Status:MEDLINE
[do] DOI:10.1007/s00535-016-1294-x


  6 / 4801 MEDLINE  
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[PMID]:27802577
[Au] Autor:Korkuc P; Walther D
[Ad] Endereço:Max Planck Institute for Molecular Plant Physiology, Am Mühlenberg 1, Potsdam-Golm, 14476, Germany.
[Ti] Título:Towards understanding the crosstalk between protein post-translational modifications: Homo- and heterotypic PTM pair distances on protein surfaces are not random.
[So] Source:Proteins;85(1):78-92, 2017 Jan.
[Is] ISSN:1097-0134
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Post-translational modifications (PTMs) represent an important regulatory layer influencing the structure and function of proteins. With broader availability of experimental information on the occurrences of different PTM types, the investigation of a potential "crosstalk" between different PTM types and combinatorial effects have moved into the research focus. Hypothesizing that relevant interferences between different PTM types and sites may become apparent when investigating their mutual physical distances, we performed a systematic survey of pairwise homo- and heterotypic distances of seven frequent PTM types considering their sequence and spatial distances in resolved protein structures. We found that actual PTM site distance distributions differ from random distributions with most PTM type pairs exhibiting larger than expected distances with the exception of homotypic phosphorylation site distances and distances between phosphorylation and ubiquitination sites that were found to be closer than expected by chance. Random reference distributions considering canonical acceptor amino acid residues only were found to be shifted to larger distances compared to distances between any amino acid residue type indicating an underlying tendency of PTM-amenable residue types to be further apart than randomly expected. Distance distributions based on sequence separations were found largely consistent with their spatial counterparts suggesting a primary role of sequence-based pairwise PTM-location encoding rather than folding-mediated effects. Our analysis provides a systematic and comprehensive overview of the characteristics of pairwise PTM site distances on proteins and reveals that, predominantly, PTM sites tend to avoid close proximity with the potential implication that an independent attachment or removal of PTMs remains possible. Proteins 2016; 85:78-92. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Processamento de Proteína Pós-Traducional
Análise de Sequência de Proteína
[Mh] Termos MeSH secundário: Acetilação
Sequência de Aminoácidos
Animais
Glicosilação
Seres Humanos
Metilação
Camundongos
Compostos Nitrosos
Fosforilação
Conformação Proteica
Ratos
Sumoilação
Ubiquitinação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitroso Compounds)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161102
[St] Status:MEDLINE
[do] DOI:10.1002/prot.25200


  7 / 4801 MEDLINE  
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[PMID]:27596392
[Au] Autor:González-Jiménez M; Arenas-Valgañón J; García-Santos Mdel P; Calle E; Casado J
[Ad] Endereço:Departamento de Química Física, Universidad de Salamanca, Plaza de los Caídos, 1-5, E-37008 Salamanca, Spain.
[Ti] Título:Mutagenic products are promoted in the nitrosation of tyramine.
[So] Source:Food Chem;216:60-5, 2017 Feb 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Tyramine is a biogenic compound derived from the decarboxylation of the amino acid tyrosine, and is therefore present at important concentrations in a broad range of raw and fermented foods. Owing to its chemical properties, tyramine can react with nitrite, a common food additive, in the acidic medium of stomach to form N- and C-nitroso compounds. Since toxicology studies have shown that the product of C-nitrosation of tyramine is mutagenic, in the present article tyramine nitrosation mechanisms have been characterized in order to discern which of them are favoured under conditions similar to those in the human stomach lumen. To determine the kinetic course of nitrosation reactions, a systematic study of the nitrosation of ethylbenzene, phenethylamine, and tyramine was carried out, using UV-visible absorption spectroscopy. The results show that, under conditions mimicking those of the stomach lumen, the most favoured reaction in tyramine is C-nitrosation, which generates mutagenic products.
[Mh] Termos MeSH primário: Mutagênicos/química
Tiramina/química
[Mh] Termos MeSH secundário: Derivados de Benzeno/química
Seres Humanos
Modelos Teóricos
Nitritos/química
Nitrosação
Compostos Nitrosos/química
Fenetilaminas/química
Estômago/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzene Derivatives); 0 (Mutagens); 0 (Nitrites); 0 (Nitroso Compounds); 0 (Phenethylamines); 327C7L2BXQ (phenethylamine); L5I45M5G0O (ethylbenzene); X8ZC7V0OX3 (Tyramine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170110
[Lr] Data última revisão:
170110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160907
[St] Status:MEDLINE


  8 / 4801 MEDLINE  
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[PMID]:27075937
[Au] Autor:Titov VY; Osipov AN
[Ad] Endereço:a NI Pirogov Russian National Research Medical University , 1 Ostrovityanov St, 117997 Moscow , Russia.
[Ti] Título:Nitrite and nitroso compounds can serve as specific catalase inhibitors.
[So] Source:Redox Rep;22(2):91-97, 2017 Mar.
[Is] ISSN:1743-2928
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We present evidence that nitrite and nitrosothiols, nitrosoamines and non-heme dinitrosyl iron complexes can reversibly inhibit catalase with equal effectiveness. METHODS: Catalase activity was evaluated by the permanganatometric and calorimetric assays. RESULTS: This inhibition is not the result of chemical transformations of these compounds to a single inhibitor, as well as it is not the result of NO release from these substances (as NO traps have no effect on the extent of inhibition). It was found that chloride and bromide in concentration above 80 mM and thiocyanate in concentration above 20 µM enhance catalase inhibition by nitrite and the nitroso compounds more than 100 times. The inhibition degree in this case is comparable with that induced by azide. DISCUSSION: We propose that the direct catalase inhibitor is a positively charged NO-group. This group acquires a positive charge in the active center of enzyme by interaction of nitrite or nitroso compounds with some enzyme groups. Halides and thiocyanate protect the NO group from hydration and thus increase its inhibition effect. It is probable that a comparatively low chloride concentration in many cells is the main factor to protect catalase from inhibition by nitrite and nitroso compounds.
[Mh] Termos MeSH primário: Catalase/antagonistas & inibidores
Inibidores Enzimáticos/farmacologia
Nitritos/farmacologia
Compostos Nitrosos/farmacologia
[Mh] Termos MeSH secundário: Calorimetria/métodos
Catalase/metabolismo
Inibidores Enzimáticos/química
Concentração de Íons de Hidrogênio
Ferro/química
Ferro/farmacologia
Nitritos/química
Óxidos de Nitrogênio/química
Óxidos de Nitrogênio/farmacologia
Compostos Nitrosos/química
S-Nitrosotióis/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Nitrites); 0 (Nitrogen Oxides); 0 (Nitroso Compounds); 0 (S-Nitrosothiols); 68586-27-6 (dinitrosyl iron complex); E1UOL152H7 (Iron); EC 1.11.1.6 (Catalase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160415
[St] Status:MEDLINE
[do] DOI:10.1080/13510002.2016.1168589


  9 / 4801 MEDLINE  
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[PMID]:26075652
[Au] Autor:Chiang VS; Quek SY
[Ad] Endereço:a Liggins Institute, The University of Auckland , Auckland , New Zealand.
[Ti] Título:The relationship of red meat with cancer: Effects of thermal processing and related physiological mechanisms.
[So] Source:Crit Rev Food Sci Nutr;57(6):1153-1173, 2017 Apr 13.
[Is] ISSN:1549-7852
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Red meat is consumed globally and plays an important role in the Western diet. Its consumption is however linked with various types of diseases. This review focuses on the relationship of red meat with cancer, its dependency on the thermal processing methodology and the subsequent physiological effects. The epidemiological evidence is discussed, followed by introduction of the species that were hypothesized to contribute to these carcinogenic effects including polycyclic aromatic hydrocarbons (PAHs), heterocyclic amines (HCAs), N-nitroso compounds (NOCs), heme iron, and macromolecular oxidation products. Their carcinogenic mechanisms were then addressed with further emphasis on the involvement of inflammation and oxidative stress. The thermal processing dependency of the carcinogen generation and the partially elucidated carcinogenic mechanism both represent doorways of opportunities available for the scientific manipulation of their impact after human consumption, to minimize the cancer risks associated with red meat.
[Mh] Termos MeSH primário: Culinária
Temperatura Alta
Neoplasias/epidemiologia
Carne Vermelha/efeitos adversos
Carne Vermelha/análise
[Mh] Termos MeSH secundário: Aminas/análise
Aminas/toxicidade
Animais
Carcinógenos/análise
Carcinógenos/toxicidade
Seres Humanos
Inflamação/induzido quimicamente
Inflamação/prevenção & controle
Metanálise como Assunto
Compostos Nitrosos/análise
Compostos Nitrosos/toxicidade
Estresse Oxidativo/efeitos dos fármacos
Hidrocarbonetos Aromáticos Policíclicos/análise
Hidrocarbonetos Aromáticos Policíclicos/toxicidade
Ensaios Clínicos Controlados Aleatórios como Assunto
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Amines); 0 (Carcinogens); 0 (Nitroso Compounds); 0 (Polycyclic Aromatic Hydrocarbons)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170315
[Lr] Data última revisão:
170315
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150616
[St] Status:MEDLINE
[do] DOI:10.1080/10408398.2014.967833


  10 / 4801 MEDLINE  
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[PMID]:28025551
[Au] Autor:Palmieri A
[Ad] Endereço:Green Chemistry Group, School of Sciences and Technology, Chemistry Division, University of Camerino, via S. Agostino 1, 62032 Camerino (MC), Italy. Alessandro.palmieri@unicam.it.
[Ti] Título:Special Issue "Recent Synthetic Aspects on the Chemistry of Nitro, Nitroso and Amino Compounds".
[So] Source:Molecules;22(1), 2016 Dec 23.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Nitrogen-containing molecules are key scaffolds that are widely applied in organic synthesis as precursors of highly functionalized materials, and are also investigated for their biological activities. This Special Issue collects seven innovative contributions which expand our knowledge of the chemistry of nitro compounds, amines, diazonium salts, and peptides, and that provide a good overview about their main reactivities.
[Mh] Termos MeSH primário: Aminas/química
Nitrocompostos/química
Compostos Nitrosos/química
[Mh] Termos MeSH secundário: Peptídeos/química
Compostos de Amônio Quaternário/química
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Amines); 0 (Nitro Compounds); 0 (Nitroso Compounds); 0 (Peptides); 0 (Quaternary Ammonium Compounds)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161228
[St] Status:MEDLINE



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