Base de dados : MEDLINE
Pesquisa : D02.675.800 [Categoria DeCS]
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[PMID]:29311461
[Au] Autor:Nambu H
[Ad] Endereço:Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama.
[Ti] Título:[Novel Methods for the Synthesis of Heterocycles Using Highly Reactive Spirocyclopropanes].
[So] Source:Yakugaku Zasshi;138(1):19-25, 2018.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:This review describes our recent efforts to develop efficient methods for the synthesis of heterocyclic compounds, such as indoles and benzofurans, employing ring-opening cyclization of cyclohexane-1,3-dione-2-spirocyclopropanes, which were prepared by the reaction of 1,3-cyclohexanediones with sulfonium salts. Ring-opening cyclization of cyclohexane-1,3-dione-2-spirocyclopropanes with primary amines proceeded at room temperature to provide 2-substituted tetrahydroindol-4(5H)-ones in good to excellent yield. The obtained product was readily converted into a 2-substituted 4-hydroxyindole derivative. Furthermore, acid-catalyzed ring-opening cyclization of cyclohexane-1,3-dione-2-spirocyclopropanes proceeded smoothly at room temperature to provide 2-substituted tetrahydrobenzofuran-4(2H)-ones in excellent yield. The obtained product was converted into a 2-substituted 4-hydroxybenzofuran derivative. The synthetic utility of this catalytic protocol was demonstrated by the total synthesis of cuspidan B.
[Mh] Termos MeSH primário: Química Orgânica/métodos
Compostos Heterocíclicos/síntese química
[Mh] Termos MeSH secundário: Aminas/química
Benzofuranos/síntese química
Catálise
Ciclização
Cicloexanos/síntese química
Cicloexanonas/química
Ciclopropanos/síntese química
Indóis/síntese química
Fenômenos de Química Orgânica
Alimentos de Soja
Estilbenos/síntese química
Compostos de Sulfônio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Amines); 0 (Benzofurans); 0 (Cyclohexanes); 0 (Cyclohexanones); 0 (Cyclopropanes); 0 (Heterocyclic Compounds); 0 (Indoles); 0 (Stilbenes); 0 (Sulfonium Compounds); 0 (cuspidan B); 6UK3D2BXJT (1,3-cyclohexanedione)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00188


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[PMID]:28885019
[Au] Autor:Quadri M; Stokes C; Gulsevin A; Felts ACJ; Abboud KA; Papke RL; Horenstein NA
[Ad] Endereço:Department of Chemistry, University of Florida , P.O. Box 117200, Gainesville, Florida 32611-7200, United States.
[Ti] Título:Sulfonium as a Surrogate for Ammonium: A New α7 Nicotinic Acetylcholine Receptor Partial Agonist with Desensitizing Activity.
[So] Source:J Med Chem;60(18):7928-7934, 2017 Sep 28.
[Is] ISSN:1520-4804
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Weak partial agonists that promote a desensitized state of the α7 nicotinic acetylcholine receptor (nAChR) have been associated with anti-inflammatory effects. Exemplar compounds feature a tertiary or quaternary ammonium group. We report the synthesis, structure, and electrophysiological evaluation of 1-ethyl-4-phenylthiomorpholin-1-ium triflate, a weak partial agonist with a sulfonium isostere of the ammonium pharmacophore. These results offer new insights in understanding nAChR-ligand interactions and provide a new chemical space to target the α7 nAChR.
[Mh] Termos MeSH primário: Morfolinas/química
Morfolinas/farmacologia
Agonistas Nicotínicos/química
Agonistas Nicotínicos/farmacologia
Oniocompostos/química
Oniocompostos/farmacologia
Compostos de Sulfônio/química
Compostos de Sulfônio/farmacologia
Receptor Nicotínico de Acetilcolina alfa7/agonistas
[Mh] Termos MeSH secundário: Compostos de Amônio/síntese química
Compostos de Amônio/química
Compostos de Amônio/farmacologia
Animais
Seres Humanos
Modelos Moleculares
Morfolinas/síntese química
Agonistas Nicotínicos/síntese química
Oniocompostos/síntese química
Compostos de Sulfônio/síntese química
Xenopus laevis
Receptor Nicotínico de Acetilcolina alfa7/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (1-ethyl-4-phenylthiomorpholin-1-ium); 0 (Ammonium Compounds); 0 (Morpholines); 0 (Nicotinic Agonists); 0 (Onium Compounds); 0 (Sulfonium Compounds); 0 (alpha7 Nicotinic Acetylcholine Receptor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jmedchem.7b00875


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[PMID]:28683918
[Au] Autor:Dey M
[Ad] Endereço:The University of Iowa, Iowa City, IA, United States. Electronic address: mishtu-dey@uiowa.edu.
[Ti] Título:Enzymology of Microbial Dimethylsulfoniopropionate Catabolism.
[So] Source:Adv Protein Chem Struct Biol;109:195-222, 2017.
[Is] ISSN:1876-1623
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The biochemistry of dimethylsulfoniopropionate (DMSP) catabolism is reviewed. The microbes that catalyze the reactions central to DMSP catabolic pathways are described, and the focus is on the enzymology of the process. Approximately 10 tons of DMSP is released annually by marine eukaryotes as an osmolyte. A vast majority of DMSP is assimilated by bacteria through either a demethylation or lyase pathways, producing either the methane thiol or the volatile dimethylsulfide (DMS), respectively. Enzymatic breakdown of DMSP generates ~10 tons of DMS annually, which may have impact on global climate. DMS also acts as a chemoattractant for zooplanktons and seabirds. Both DMSP and DMS play a key role in the global sulfur cycle and are key nutrients for marine microbial growth. Important enzymes in the biochemical pathways of DMSP catabolism are covered in this review, with a focus on the latest developments in their mechanism.
[Mh] Termos MeSH primário: Bactérias/enzimologia
Bactérias/metabolismo
Proteínas de Bactérias/metabolismo
Compostos de Sulfônio/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Bactérias/química
Bactérias/genética
Proteínas de Bactérias/química
Proteínas de Bactérias/genética
Coenzima A-Transferases/química
Coenzima A-Transferases/genética
Coenzima A-Transferases/metabolismo
Regulação Bacteriana da Expressão Gênica
Liases/química
Liases/genética
Liases/metabolismo
Redes e Vias Metabólicas
Modelos Moleculares
Conformação Proteica
Proteobactérias/química
Proteobactérias/enzimologia
Proteobactérias/genética
Proteobactérias/metabolismo
Compostos de Sulfônio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Sulfonium Compounds); C884XA7QGG (dimethylpropiothetin); EC 2.8.3.- (Coenzyme A-Transferases); EC 4.- (Lyases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


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[PMID]:28511016
[Au] Autor:Schnicker NJ; De Silva SM; Todd JD; Dey M
[Ad] Endereço:Department of Chemistry, The University of Iowa , Iowa City, Iowa 52242, United States.
[Ti] Título:Structural and Biochemical Insights into Dimethylsulfoniopropionate Cleavage by Cofactor-Bound DddK from the Prolific Marine Bacterium Pelagibacter.
[So] Source:Biochemistry;56(23):2873-2885, 2017 Jun 13.
[Is] ISSN:1520-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Enormous amounts of the organic osmolyte dimethylsulfoniopropionate (DMSP) are produced in marine environments where bacterial DMSP lyases cleave it, yielding acrylate and the climate-active gas dimethyl sulfide (DMS). SAR11 bacteria are the most abundant clade of heterotrophic bacteria in the oceans and play a key role in DMSP catabolism. An important environmental factor affecting DMS generation via DMSP lyases is the availability of metal ions because they are essential cofactors for many of these enzymes. Here we examine the structure and activity of DddK in the presence of various metal ions. We have established that DddK containing a double-stranded ß-helical motif utilizes various divalent metal ions as cofactors for catalytic activity. However, nickel, an abundant metal ion in marine environments, adopts a distorted octahedral coordination environment and conferred the highest DMSP lyase activity. Crystal structures of cofactor-bound DddK reveal key metal ion binding and catalytic residues and provide the first rationalization for varying activities with different metal ions. The structures of DddK along with site-directed mutagenesis and ultraviolet-visible studies are consistent with Tyr 64 acting as a base to initiate the ß-elimination reaction of DMSP. Our biochemical and structural studies provide a detailed understanding of DMS generation by one of the ocean's most prolific bacteria.
[Mh] Termos MeSH primário: Alphaproteobacteria/enzimologia
Organismos Aquáticos/enzimologia
Proteínas de Bactérias/metabolismo
Liases de Carbono-Enxofre/metabolismo
Modelos Moleculares
Compostos de Sulfônio/metabolismo
[Mh] Termos MeSH secundário: Acrilatos/metabolismo
Alphaproteobacteria/crescimento & desenvolvimento
Sequência de Aminoácidos
Organismos Aquáticos/crescimento & desenvolvimento
Proteínas de Bactérias/química
Proteínas de Bactérias/genética
Sítios de Ligação
Liases de Carbono-Enxofre/química
Liases de Carbono-Enxofre/genética
Domínio Catalítico
Sequência Conservada
Cristalografia por Raios X
Mutagênese Sítio-Dirigida
Mutação
Níquel/química
Oceanos e Mares
Conformação Proteica
Conformação Proteica em Folha beta
Proteínas Recombinantes de Fusão/química
Proteínas Recombinantes de Fusão/metabolismo
Alinhamento de Sequência
Sulfetos/metabolismo
Compostos de Sulfônio/química
Tirosina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylates); 0 (Bacterial Proteins); 0 (Recombinant Fusion Proteins); 0 (Sulfides); 0 (Sulfonium Compounds); 42HK56048U (Tyrosine); 7OV03QG267 (Nickel); C884XA7QGG (dimethylpropiothetin); EC 4.4.- (Carbon-Sulfur Lyases); EC 4.4.- (dimethylsulfoniopropionate lyase); J94PBK7X8S (acrylic acid); QS3J7O7L3U (dimethyl sulfide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170706
[Lr] Data última revisão:
170706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.1021/acs.biochem.7b00099


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[PMID]:28028804
[Au] Autor:Peckol P; Putnam AB
[Ad] Endereço:Department of Biological Sciences, Smith College, Northampton, Massachusetts, 01063, USA.
[Ti] Título:Differential toxic effects of Ulva lactuca (Chlorophyta) on the herbivorous gastropods, Littorina littorea and L. obtusata (Mollusca).
[So] Source:J Phycol;53(2):361-367, 2017 Apr.
[Is] ISSN:1529-8817
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Members of the genus Ulva are widespread and abundant in intertidal and shallow subtidal areas but there are conflicting data regarding susceptibility to herbivory. While some studies have documented that Ulva spp. were favored by a diversity of marine herbivores, other work has revealed herbivore deterrence. We investigated grazing and growth rates of the littorinid species, Littorina littorea and L. obtusata, when offered Fucus vesiculosus, Ascophyllum nodosum, Ulva lactuca, and Chondrus crispus, highlighting distinctive vulnerabilities to toxic effects of U. lactuca. Ulva lactuca was the preferred food of L. littorea, while L. obtusata showed no grazing on this ephemeral algal species. In contrast, F. vesiculosus was highly preferred by L. obtusata. Although L. littorea demonstrated a grazing preference for U. lactuca, growth rate of this gastropod species was nearly 3× greater when fed F. vesiculosus, suggesting a non-lethal, negative effect of U. lactuca on L. littorea with long-term exposure. Mortality of L. obtusata ranged from 0% to 100% when held in the presence of various Ulva densities for 1 week, and Ulva exudate depressed herbivory of this gastropod. We conclude that the water-soluble, toxic exudate produced by U. lactuca in response to herbivory had allelochemical properties, and may contain a cleavage product (acrylic acid) of dimethylsulfoniopropionate or reactive oxygen species (i.e., H O ). Observed differences in susceptibility to Ulva toxicity by the littorinid species may be related to generalist versus specialist feeding and habitat strategies.
[Mh] Termos MeSH primário: Clorófitas/toxicidade
Herbivoria/efeitos dos fármacos
Moluscos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Acrilatos/metabolismo
Animais
Moluscos/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Compostos de Sulfônio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylates); 0 (Reactive Oxygen Species); 0 (Sulfonium Compounds); C884XA7QGG (dimethylpropiothetin); J94PBK7X8S (acrylic acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161229
[St] Status:MEDLINE
[do] DOI:10.1111/jpy.12507


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[PMID]:27697375
[Au] Autor:Jung H; Kah D; Chan Lim K; Lee JY
[Ad] Endereço:Agency for Defense Development, Yuseong-Gu, Daejeon 305-600, South Korea. Electronic address: junghs@add.re.kr.
[Ti] Título:Fate of sulfur mustard on soil: Evaporation, degradation, and vapor emission.
[So] Source:Environ Pollut;220(Pt A):478-486, 2017 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:After application of sulfur mustard to the soil surface, its possible fate via evaporation, degradation following absorption, and vapor emission after decontamination was studied. We used a laboratory-sized wind tunnel, thermal desorber, gas chromatograph-mass spectrometry (GC-MS), and C nuclear magnetic resonance ( C NMR) for systematic analysis. When a drop of neat HD was deposited on the soil surface, it evaporated slowly while being absorbed immediately into the matrix. The initial evaporation or drying rates of the HD drop were found to be power-dependent on temperature and initial drop volume. Moreover, drops of neat HD, ranging in size from 1 to 6 µL, applied to soil, evaporated at different rates, with the smaller drops evaporating relatively quicker. HD absorbed into soil remained for a month, degrading eventually to nontoxic thiodiglycol via hydrolysis through the formation of sulfonium ions. Finally, a vapor emission test was performed for HD contaminant after a decontamination process, the results of which suggest potential risk from the release of trace chemical quantities of HD into the environment.
[Mh] Termos MeSH primário: Substâncias para a Guerra Química/química
Descontaminação/métodos
Gás de Mostarda/química
Poluentes do Solo/química
Solo/química
[Mh] Termos MeSH secundário: Dessecação
Cromatografia Gasosa-Espectrometria de Massas
Hidrólise
Espectroscopia de Ressonância Magnética
Medição de Risco
Compostos de Sulfidrila/química
Sulfetos/química
Compostos de Sulfônio/química
Temperatura Ambiente
Volatilização
Vento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chemical Warfare Agents); 0 (Soil); 0 (Soil Pollutants); 0 (Sulfhydryl Compounds); 0 (Sulfides); 0 (Sulfonium Compounds); 9BW5T43J04 (2,2'-thiodiethanol); T8KEC9FH9P (Mustard Gas)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161005
[St] Status:MEDLINE


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[PMID]:27920523
[Au] Autor:Fadhel AA; Yue X; Ghazvini Zadeh EH; Bondar MV; Belfield KD
[Ad] Endereço:Department of Chemistry, University of Central Florida, Orlando, FL, USA.
[Ti] Título:Pegylated and nanoparticle-conjugated sulfonium salt photo triggers necrotic cell death.
[So] Source:Int J Nanomedicine;11:6161-6168, 2016.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Photodynamic therapy (PDT) processes involving the production of singlet oxygen face the issue of oxygen concentration dependency. Despite high oxygen delivery, a variety of properties related to metabolism and vascular morphology in cancer cells result in hypoxic environments, resulting in limited effectiveness of such therapies. An alternative oxygen-independent agent whose cell cytotoxicity can be remotely controlled by light may allow access to treatment of hypoxic tumors. Toward that end, we developed and tested both polyethylene glycol (PEG)-functionalized and hydrophilic silica nanoparticle (SiNP)-enriched photoacid generator (PAG) as a nontraditional PDT agent to effectively induce necrotic cell death in HCT-116 cells. Already known for applications in lithography and cationic polymerization, our developed oxygen-independent PDT, whether free or highly monodispersed on SiNPs, generates acid when a one-photon (1P) or two-photon (2P) excitation source is used, thus potentially permitting deep tissue treatment. Our study shows that when conjugated to SiNPs with protruding amine functionalities (SiNP-PAG9), such atypical PDT agents can be effectively delivered into HCT-116 cells and compartmentalize exclusively in lysosomes and endosomes. Loss of cell adhesion and cell swelling are detected when an excitation source is applied, suggesting that SiNP-PAG9, when excited via near-infrared 2P absorption (a subject of future investigation), can be used as a delivery system to selectively induce cell death in oxygen-deprived optically thick tissue.
[Mh] Termos MeSH primário: Adesão Celular/efeitos dos fármacos
Morte Celular/efeitos dos fármacos
Luz
Nanopartículas/química
Fármacos Fotossensibilizantes/farmacologia
Polietilenoglicóis/química
Compostos de Sulfônio/farmacologia
[Mh] Termos MeSH secundário: Células HCT116
Seres Humanos
Interações Hidrofóbicas e Hidrofílicas
Necrose
Oxigênio/metabolismo
Fotoquimioterapia/métodos
Fótons
Fármacos Fotossensibilizantes/química
Dióxido de Silício/química
Oxigênio Singlete/metabolismo
Compostos de Sulfônio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Photosensitizing Agents); 0 (Sulfonium Compounds); 17778-80-2 (Singlet Oxygen); 30IQX730WE (Polyethylene Glycols); 7631-86-9 (Silicon Dioxide); S88TT14065 (Oxygen)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161207
[St] Status:MEDLINE


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[PMID]:27904084
[Au] Autor:Nambu H; Ono N; Hirota W; Fukumoto M; Yakura T
[Ad] Endereço:Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama.
[Ti] Título:An Efficient Method for the Synthesis of 2',3'-Nonsubstituted Cycloalkane-1,3-dione-2-spirocyclopropanes Using (2-Bromoethyl)diphenylsulfonium Trifluoromethanesulfonate.
[So] Source:Chem Pharm Bull (Tokyo);64(12):1763-1768, 2016.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:An efficient and practical synthesis of 2',3'-nonsubstituted cyclohexane-1,3-dione-2-spirocyclopropanes using a sulfonium salt was achieved. The reaction of 1,3-cyclohexanediones and (2-bromoethyl)diphenylsulfonium trifluoromethanesulfonate with powdered K CO in EtOAc at room temperature (r.t.) provided the corresponding spirocyclopropanes in high yields. The synthetic method was also applied to 1,3-cyclopentanedione, 1,3-cycloheptanedione, 1,3-indanedione, acyclic 1,3-diones, ethyl acetoacetate, and Meldrum's acid.
[Mh] Termos MeSH primário: Oniocompostos/química
Compostos de Espiro/síntese química
Compostos de Sulfônio/química
[Mh] Termos MeSH secundário: Estrutura Molecular
Compostos de Espiro/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Onium Compounds); 0 (Spiro Compounds); 0 (Sulfonium Compounds)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170131
[Lr] Data última revisão:
170131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[St] Status:MEDLINE


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[PMID]:27870899
[Au] Autor:Lajin B; Francesconi KA
[Ad] Endereço:Institute of Chemistry-Analytical Chemistry, NAWI Graz, University of Graz, Universitaetsplatz 1, 8010, Graz, Austria.
[Ti] Título:The Association between the Urinary Excretion of Trimethylselenonium and Trimethylsulfonium in Humans.
[So] Source:PLoS One;11(11):e0167013, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hydrogen sulfide is a signaling molecule that plays important roles in several physiological processes, and its methylation product trimethylsulfonium (TMS) is a natural constituent of human urine that could serve as a biomarker for hydrogen sulfide. In vitro studies showed that the enzyme indole-ethylamine N-methyltransferase (INMT) is responsible for the production of trimethylsulfonium as well as its selenium analogue trimethylselenonium (TMSe). Marked inter-individual variability in TMSe production is associated with genetic polymorphisms in the INMT gene, but it remains unclear whether these polymorphisms affect substrate specificity or general enzymatic activity. Therefore, we explore the association between the TMS and TMSe production phenotypes. Caucasian volunteers were recruited and grouped according to their TMSe status into "TMSe producers" and "TMSe non-producers", and morning urine samples were collected over 5 consecutive days from each volunteer. A total of 125 urine samples collected from 25 volunteers (13 TMSe producers and 12 TMSe non-producers) were analyzed for total selenium and total sulfur using inductively coupled plasma mass spectrometry (ICPMS), trimethylselenonium using HPLC/ICPMS, and trimethylsulfonium using HPLC/electrospray ionization-triple quadrupole-mass spectrometry (ESI-QQQ-MS). Although there was no correlation between TMS and TMSe urinary levels within the "TMSe producers" group, the "TMSe producers" had urinary levels of TMS 10-fold higher than those of the "TMSe non-producers" (P < 0.001). This result indicates that stratification according to TMSe status or genotype is crucial for the correct interpretation of urinary TMS as a possible biomarker for hydrogen sulfide body pools.
[Mh] Termos MeSH primário: Compostos de Selênio/urina
Compostos de Sulfônio/urina
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/urina
Cromatografia Líquida de Alta Pressão
Feminino
Seres Humanos
Sulfeto de Hidrogênio/metabolismo
Masculino
Metiltransferases/metabolismo
Meia-Idade
Espectrometria de Massas por Ionização por Electrospray
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biomarkers); 0 (Selenium Compounds); 0 (Sulfonium Compounds); 8U5M0SJV65 (trimethylsulfonium); EC 2.1.1.- (Methyltransferases); EC 2.1.1.49 (tryptamine N-methyltransferase); SL67TG557G (trimethylselenonium); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170623
[Lr] Data última revisão:
170623
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161122
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0167013


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[PMID]:27548380
[Au] Autor:Walter JM; Tschoeke DA; Meirelles PM; de Oliveira L; Leomil L; Tenório M; Valle R; Salomon PS; Thompson CC; Thompson FL
[Ad] Endereço:Laboratory of Microbiology, Institute of Biology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
[Ti] Título:Taxonomic and Functional Metagenomic Signature of Turfs in the Abrolhos Reef System (Brazil).
[So] Source:PLoS One;11(8):e0161168, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Turfs are widespread assemblages (consisting of microbes and algae) that inhabit reef systems. They are the most abundant benthic component in the Abrolhos reef system (Brazil), representing greater than half the coverage of the entire benthic community. Their presence is associated with a reduction in three-dimensional coral reef complexity and decreases the habitats available for reef biodiversity. Despite their importance, the taxonomic and functional diversity of turfs remain unclear. We performed a metagenomics and pigments profile characterization of turfs from the Abrolhos reefs. Turf microbiome primarily encompassed Proteobacteria (mean 40.57% ± s.d. 10.36, N = 1.548,192), Cyanobacteria (mean 35.04% ± s.d. 15.5, N = 1.337,196), and Bacteroidetes (mean 11.12% ± s.d. 4.25, N = 424,185). Oxygenic and anoxygenic phototrophs, chemolithotrophs, and aerobic anoxygenic phototrophic (AANP) bacteria showed a conserved functional trait of the turf microbiomes. Genes associated with oxygenic photosynthesis, AANP, sulfur cycle (S oxidation, and DMSP consumption), and nitrogen metabolism (N2 fixation, ammonia assimilation, dissimilatory nitrate and nitrite ammonification) were found in the turf microbiomes. Principal component analyses of the most abundant taxa and functions showed that turf microbiomes differ from the other major Abrolhos benthic microbiomes (i.e., corals and rhodoliths) and seawater. Taken together, these features suggest that turfs have a homogeneous functional core across the Abrolhos Bank, which holds diverse microbial guilds when comparing with other benthic organisms.
[Mh] Termos MeSH primário: Cianobactérias/genética
DNA Bacteriano/genética
Metagenômica
Microbiota/genética
Filogenia
Proteobactérias/genética
[Mh] Termos MeSH secundário: Amônia/metabolismo
Animais
Antozoários/fisiologia
Bacteroidetes
Biodiversidade
Brasil
Recifes de Corais
Cianobactérias/classificação
Cianobactérias/metabolismo
Código de Barras de DNA Taxonômico
Consórcios Microbianos/genética
Nitrogênio/metabolismo
Fotossíntese
Pigmentos Biológicos/biossíntese
Análise de Componente Principal
Proteobactérias/classificação
Proteobactérias/metabolismo
Água do Mar/microbiologia
Compostos de Sulfônio/metabolismo
Enxofre/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Pigments, Biological); 0 (Sulfonium Compounds); 70FD1KFU70 (Sulfur); 7664-41-7 (Ammonia); C884XA7QGG (dimethylpropiothetin); N762921K75 (Nitrogen)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160823
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0161168



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