Base de dados : MEDLINE
Pesquisa : D02.691 [Categoria DeCS]
Referências encontradas : 39037 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 3904 ir para página                         

  1 / 39037 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28841528
[Au] Autor:Lavtizar V; Kimura D; Asaoka S; Okamura H
[Ad] Endereço:Laboratory of Maritime Environmental Management, Research Center for Inland Seas, Kobe University, 5-1-1 Fukaeminami, Higashinada-ku, Kobe, Hyogo 658-0022, Japan.
[Ti] Título:The influence of seawater properties on toxicity of copper pyrithione and its degradation product to brine shrimp Artemia salina.
[So] Source:Ecotoxicol Environ Saf;147:132-138, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Copper pyrithione (CuPT) is a biocide, used worldwide to prevent biofouling on submerged surfaces. In aquatic environments it rapidly degrades, however, one of the degradation products (HPT) is known to react with cupric ion back to its parent compound. Not much is known about the behavior and toxicity of CuPT and its degradation product HPT in different water systems. Hence, our aim was to investigate the ecotoxicity of CuPT, HPT as well as Cu to the brine shrimp Artemia salina in natural seawater and organic matter-free artificial seawater. Moreover, in order to elucidate the influence of ionic strength of water on CuPT toxicity, tests were performed in water media with modified salinity. The results showed that CuPT was the most toxic to the exposed crustaceans in a seawater media with the highest salinity and with no organic matter content. HPT in a presence of cupric ion converted to CuPT, but the measured CuPT concentrations and the mortality of A. salina in natural water were lower than in artificial water. The toxicity of CuPT to A. salina was significantly influenced by the organic matter content, salinity, and proportions of constituent salts in water. In a combination with cupric ion, non-hazardous degradation product HPT exhibits increased toxicity due to its rapid transformation to its parent compound.
[Mh] Termos MeSH primário: Artemia/efeitos dos fármacos
Desinfetantes/toxicidade
Compostos Organometálicos/toxicidade
Piridinas/toxicidade
Água do Mar/química
Tionas/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Desinfetantes/análise
Monitoramento Ambiental/métodos
Substâncias Húmicas/análise
Compostos Organometálicos/análise
Piridinas/análise
Salinidade
Tionas/análise
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Disinfectants); 0 (Humic Substances); 0 (Organometallic Compounds); 0 (Pyridines); 0 (Thiones); 0 (Water Pollutants, Chemical); 0 (copper pyrithione); 6GK82EC25D (pyrithione)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE


  2 / 39037 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28822260
[Au] Autor:Omouri Z; Hawari J; Fournier M; Robidoux PY
[Ad] Endereço:INRS-Institut Armand Frappier, 531 boulevard des Prairies, Laval, Québec, Canada H7V 1B7; National Research Council of Canada, 6100 Avenue Royalmount, Montréal, Québec, Canada H4P 2R2. Electronic address: Zohra.Omouri@iaf.inrs.ca.
[Ti] Título:Bioavailability and chronic toxicity of bismuth citrate to earthworm Eisenia andrei exposed to natural sandy soil.
[So] Source:Ecotoxicol Environ Saf;147:1-8, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present study describes bioavailability and chronic effects of bismuth to earthworms Eisenia andrei using OECD reproduction test. Adult earthworms were exposed to natural sandy soil contaminated artificially by bismuth citrate. Average total concentrations of bismuth in soil recovered by HNO digestion ranged from 75 to 289mg/kg. Results indicate that bismuth decreased significantly all reproduction parameters of Eisenia andrei at concentrations ≥ 116mg/kg. However, number of hatched cocoons and number of juveniles seem to be more sensitive than total number of cocoons, as determined by IC ; i.e., 182, 123 and > 289mg/kg, respectively. Bismuth did not affect Eisenia andrei growth and survival, and had little effect on phagocytic efficiency of coelomocytes. The low immunotoxicity effect might be explained by the involvement of other mechanisms i.e. bismuth sequestered by metal-binding compounds. After 28 days of exposure bismuth concentrations in earthworms tissue increased with increasing bismuth concentrations in soil reaching a stationary state of 21.37mg/kg dry tissue for 243mg Bi/kg dry soil total content. Data indicate also that after 56 days of incubation the average fractions of bismuth available extracted by KNO aqueous solution in soil without earthworms varied from 0.0051 to 0.0229mg/kg, while in soil with earthworms bismuth concentration ranged between 0.310-1.347mg/kg dry soil. We presume that mucus and chelating agents produced by earthworms and by soil or/and earthworm gut microorganisms could explain this enhancement, as well as the role of dermal and ingestion routes of earthworms uptake to soil contaminant.
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Oligoquetos/efeitos dos fármacos
Compostos Organometálicos/toxicidade
Poluentes do Solo/toxicidade
Solo/química
[Mh] Termos MeSH secundário: Animais
Disponibilidade Biológica
Biomarcadores/análise
Relação Dose-Resposta a Droga
Nível de Efeito Adverso não Observado
Oligoquetos/metabolismo
Compostos Organometálicos/análise
Compostos Organometálicos/metabolismo
Fagocitose/efeitos dos fármacos
Reprodução/efeitos dos fármacos
Poluentes do Solo/análise
Poluentes do Solo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Organometallic Compounds); 0 (Soil); 0 (Soil Pollutants); HS813P8QPX (bismuth tripotassium dicitrate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170820
[St] Status:MEDLINE


  3 / 39037 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29318318
[Au] Autor:Vajs J; Pevec A; Gazvoda M; Urankar D; Goreshnik E; Polanc S; Kosmrlj J
[Ti] Título:Synthesis and X-ray Structural Analysis of the Ruthenium(III) Complex Na[trans-RuCl4(DMSO) (PyrDiaz)], the Diazene Derivative of Antitumor NAMI-Pyr.
[So] Source:Acta Chim Slov;64(4):763-770, 2017 Dec.
[Is] ISSN:1318-0207
[Cp] País de publicação:Slovenia
[La] Idioma:eng
[Ab] Resumo:Novel tetrachloridoruthenium(III) complex Na[trans-RuCl4(DMSO)(PyrDiaz)] (3) with pyridine-tethered diazenedicarboxamide PyrDiaz ligand (PyrDiaz = N1-(4-isopropylphenyl)-N2-(pyridin-2-ylmethyl)diazene-1,2-dicarboxamide) was synthesized by direct coupling of PyrDiaz with sodium trans-bis(dimethyl sulfoxide)tetrachloridoruthenate(III) (Na-[trans-Ru(DMSO)2Cl4]). Compound 3 is the analogue of the antimetastatic Ru(III) complex NAMI-A and NAMI-Pyr. Single crystal X.
[Mh] Termos MeSH primário: Antineoplásicos/síntese química
Dimetil Sulfóxido/análogos & derivados
Compostos Organometálicos/química
Rutênio/química
[Mh] Termos MeSH secundário: Antineoplásicos/química
Cristalografia por Raios X
Dimetil Sulfóxido/química
Imidas/síntese química
Imidas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Imides); 0 (Organometallic Compounds); 7UI0TKC3U5 (Ruthenium); LM321PYV3Y (diazene); YOW8V9698H (Dimethyl Sulfoxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE


  4 / 39037 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29358740
[Au] Autor:Furukawa T; Kobashi K; Kurosaki Y; Miyagawa K; Kanoda K
[Ad] Endereço:Department of Applied Physics, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan. tetsuya.furukawa@rs.tus.ac.jp.
[Ti] Título:Quasi-continuous transition from a Fermi liquid to a spin liquid in κ-(ET) Cu (CN) .
[So] Source:Nat Commun;9(1):307, 2018 01 22.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The Mott metal-insulator transition-a manifestation of Coulomb interactions among electrons-is known as a discontinuous transition. Recent theoretical studies, however, suggest that the transition is continuous if the Mott insulator carries a spin liquid with a spinon Fermi surface. Here, we demonstrate the case of a quasi-continuous Mott transition from a Fermi liquid to a spin liquid in an organic triangular-lattice system κ-(ET) Cu (CN) . Transport experiments performed under fine pressure tuning have found that as the Mott transition is approached, the Fermi liquid coherence temperature continuously falls to the scale of kelvins, with a divergent quasi-particle decay rate on the metal side, and the charge gap continuously closes on the insulator side. A Clausius-Clapeyron analysis provides thermodynamic evidence for the extremely weak first-order nature of the transition. These results provide additional support for the existence of a spinon Fermi surface, which becomes an electron Fermi surface when charges are delocalized.
[Mh] Termos MeSH primário: Metais/química
Compostos Organometálicos/química
Temperatura Ambiente
Termodinâmica
[Mh] Termos MeSH secundário: Modelos Teóricos
Pressão
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Metals); 0 (Organometallic Compounds)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02679-7


  5 / 39037 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28743763
[Au] Autor:Al-Owais MM; Hettiarachchi NT; Kirton HM; Hardy ME; Boyle JP; Scragg JL; Steele DS; Peers C
[Ad] Endereço:Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom; and.
[Ti] Título:A key role for peroxynitrite-mediated inhibition of cardiac ERG (Kv11.1) K channels in carbon monoxide-induced proarrhythmic early afterdepolarizations.
[So] Source:FASEB J;31(11):4845-4854, 2017 11.
[Is] ISSN:1530-6860
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Exposure to CO causes early afterdepolarization arrhythmias. Previous studies in rats have indicated that arrhythmias arose as a result of augmentation of the late Na current. The purpose of the present study was to examine the basis for CO-induced arrhythmias in guinea pig myocytes in which action potentials (APs) more closely resemble those of human myocytes. Whole-cell current- and voltage-clamp recordings were made from isolated guinea pig myocytes as well as from human embryonic kidney 293 (HEK293) cells that express wild-type or a C723S mutant form of ether-a-go-go-related gene (ERG; Kv11.1). We also monitored the formation of peroxynitrite (ONOO ) in HEK293 cells fluorimetrically. CO-applied as the CO-releasing molecule, CORM-2-prolonged the APs and induced early afterdepolarizations in guinea pig myocytes. In HEK293 cells, CO inhibited wild-type, but not C723S mutant, Kv11.1 K currents. Inhibition was prevented by an antioxidant, mitochondrial inhibitors, or inhibition of NO formation. CO also raised ONOO levels, an effect that was reversed by the ONOO scavenger, FeTPPS [5,10,15,20-tetrakis-(4-sulfonatophenyl)-porphyrinato-iron(III)], which also prevented the CO inhibition of Kv11.1 currents and abolished the effects of CO on Kv11.1 tail currents and APs in guinea pig myocytes. Our data suggest that CO induces arrhythmias in guinea pig cardiac myocytes the ONOO -mediated inhibition of Kv11.1 K channels.-Al-Owais, M. M., Hettiarachchi, N. T., Kirton, H. M., Hardy, M. E., Boyle, J. P., Scragg, J. L., Steele, D. S., Peers, C. A key role for peroxynitrite-mediated inhibition of cardiac ERG (Kv11.1) K channels in carbon monoxide-induced proarrhythmic early afterdepolarizations.
[Mh] Termos MeSH primário: Arritmias Cardíacas/metabolismo
Monóxido de Carbono/toxicidade
Canal de Potássio ERG1/metabolismo
Potenciais da Membrana/efeitos dos fármacos
Miócitos Cardíacos/metabolismo
Ácido Peroxinitroso/metabolismo
[Mh] Termos MeSH secundário: Animais
Arritmias Cardíacas/induzido quimicamente
Arritmias Cardíacas/genética
Arritmias Cardíacas/patologia
Canal de Potássio ERG1/genética
Cobaias
Células HEK293
Seres Humanos
Metaloporfirinas/farmacologia
Miócitos Cardíacos/patologia
Óxido Nítrico/genética
Óxido Nítrico/metabolismo
Compostos Organometálicos/farmacologia
Ácido Peroxinitroso/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride); 0 (ERG1 Potassium Channel); 0 (KCNH2 protein, human); 0 (Metalloporphyrins); 0 (Organometallic Compounds); 0 (tricarbonyldichlororuthenium (II) dimer); 14691-52-2 (Peroxynitrous Acid); 31C4KY9ESH (Nitric Oxide); 7U1EE4V452 (Carbon Monoxide)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1096/fj.201700259R


  6 / 39037 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29289889
[Au] Autor:Li Y; Gu Z; Zhang C; Li S; Zhang L; Zhou G; Wang S; Zhang J
[Ad] Endereço:Key Laboratory of Chemical Biology of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, College of Chemistry & Environmental Science, Hebei University, Baoding 071002, China.
[Ti] Título:Synthesis, characterization and ROS-mediated antitumor effects of palladium(II) complexes of curcuminoids.
[So] Source:Eur J Med Chem;144:662-671, 2018 Jan 20.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Based on the synthesis of curcumin and its derivatives from aromatic aldehydes, a novel series of palladium(II) complexes with curcumin (or its derivatives) and 2,2'-bipyridine have been synthesized through a directed self-assembly approach that involves spontaneous deprotonation of the curcuminoid ligands in H O/acetone solution. These complexes have been characterized by H ( C) NMR, HRMS and elemental analysis. Crystal structure of 3h has been determined by X-ray diffraction analysis. Their cytotoxicity was tested by MTT. The preliminary results showed that complexes 3d, 3f, 3h have significant inhibition on proliferation of three carcinoma cells such as MCF-7, HeLa and A549 cells, which were more active than cisplatin. Further mechanistic studies indicated that the tested complex 3h arrested the cell cycle in the S phase and can disrupted mitochondrial membrane potential and induced tumor cell apoptosis through reactive oxygen species (ROS)-dependent pathway.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Curcumina/farmacologia
Compostos Organometálicos/farmacologia
Espécies Reativas de Oxigênio/metabolismo
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Antineoplásicos/química
Apoptose/efeitos dos fármacos
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Curcumina/análogos & derivados
Curcumina/química
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Estrutura Molecular
Compostos Organometálicos/síntese química
Compostos Organometálicos/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Organometallic Compounds); 0 (Reactive Oxygen Species); IT942ZTH98 (Curcumin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180101
[St] Status:MEDLINE


  7 / 39037 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29329342
[Au] Autor:Ahmad M; Suhaimi SN; Chu TL; Abdul Aziz N; Mohd Kornain NK; Samiulla DS; Lo KW; Ng CH; Khoo AS
[Ad] Endereço:Molecular Pathology Unit, Cancer Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia.
[Ti] Título:Ternary copper(II) complex: NCI60 screening, toxicity studies, and evaluation of efficacy in xenograft models of nasopharyngeal carcinoma.
[So] Source:PLoS One;13(1):e0191295, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Copper(II) ternary complex, [Cu(phen)(C-dmg)(H2O)]NO3 was evaluated against a panel of cell lines, tested for in vivo efficacy in nasopharyngeal carcinoma xenograft models as well as for toxicity in NOD scid gamma mice. The Cu(II) complex displayed broad spectrum cytotoxicity against multiple cancer types, including lung, colon, central nervous system, melanoma, ovarian, and prostate cancer cell lines in the NCI-60 panel. The Cu(II) complex did not cause significant induction of cytochrome P450 (CYP) 3A and 1A enzymes but moderately inhibited CYP isoforms 1A2, 2C9, 2C19, 2D6, 2B6, 2C8 and 3A4. The complex significantly inhibited tumor growth in nasopharyngeal carcinoma xenograft bearing mice models at doses which were well tolerated without causing significant or permanent toxic side effects. However, higher doses which resulted in better inhibition of tumor growth also resulted in toxicity.
[Mh] Termos MeSH primário: Antineoplásicos/química
Antineoplásicos/farmacologia
Carcinoma/tratamento farmacológico
Cobre/química
Neoplasias Nasofaríngeas/tratamento farmacológico
Compostos Organometálicos/química
Compostos Organometálicos/farmacologia
Ensaios Antitumorais Modelo de Xenoenxerto
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/toxicidade
Carcinoma/patologia
Linhagem Celular Tumoral
Inibidores das Enzimas do Citocromo P-450/química
Inibidores das Enzimas do Citocromo P-450/farmacologia
Inibidores das Enzimas do Citocromo P-450/toxicidade
Sistema Enzimático do Citocromo P-450/biossíntese
Sistema Enzimático do Citocromo P-450/metabolismo
Relação Dose-Resposta a Droga
Indução Enzimática/efeitos dos fármacos
Feminino
Hepatócitos/efeitos dos fármacos
Camundongos
Neoplasias Nasofaríngeas/patologia
Compostos Organometálicos/toxicidade
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Cytochrome P-450 Enzyme Inhibitors); 0 (Organometallic Compounds); 789U1901C5 (Copper); 9035-51-2 (Cytochrome P-450 Enzyme System)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191295


  8 / 39037 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29217190
[Au] Autor:Unuma K; Aki T; Nagano S; Watanabe R; Uemura K
[Ad] Endereço:Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
[Ti] Título:The down-regulation of cardiac contractile proteins underlies myocardial depression during sepsis and is mitigated by carbon monoxide.
[So] Source:Biochem Biophys Res Commun;495(2):1668-1674, 2018 01 08.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study is to investigate the mechanism underling cardiac dysfunction during sepsis, as well as the possible amelioration of this dysfunction by exogenous carbon monoxide (CO) administration. For this purpose, rats (six-week-old, male, Sprague-Dawley) were administered LPS (15 mg/kg body weight, i.p. 6 h) and/or CORM (30 mg/kg, i.p.). The decreased left ventricular ejection fraction (EF) observed in LPS group rats was recovered in the LSP + CORM group, confirming the protective role of CO against sepsis-induced myocardial depression. Proteomic as well as immunoblot analysis showed that the levels of myosin heavy and light chains (MHC and MLC) as well as α-cardiac actin (ACTC) were decreased in the LPS group, and these decreases were mitigated in the LSP + CORM group, suggesting that the amounts of major contractile proteins are decreased in depressed myocardium. Not only LPS-induced inflammatory cytokine (TNFα and IL-1ß) production but also the decrease in myofilament proteins was mitigated by CORM. These results confirm the protective action of exogenously administered CO against myocardial depression during sepsis, and reveal a novel mechanism underling cardiac dysfunction during sepsis.
[Mh] Termos MeSH primário: Monóxido de Carbono/metabolismo
Proteínas Musculares/metabolismo
Miocárdio/metabolismo
Sepse/metabolismo
[Mh] Termos MeSH secundário: Actinas/genética
Actinas/metabolismo
Animais
Miosinas Cardíacas/genética
Miosinas Cardíacas/metabolismo
Cardiotônicos/farmacologia
Linhagem Celular
Citocinas/genética
Modelos Animais de Doenças
Regulação para Baixo
Expressão Gênica/efeitos dos fármacos
Lipopolissacarídeos/toxicidade
Masculino
Proteínas Musculares/genética
Contração Miocárdica/efeitos dos fármacos
Contração Miocárdica/fisiologia
Miocárdio/patologia
Compostos Organometálicos/farmacologia
Ratos
Ratos Sprague-Dawley
Proteínas Ligases SKP Culina F-Box/metabolismo
Sepse/tratamento farmacológico
Sepse/patologia
Proteínas com Motivo Tripartido/metabolismo
Ubiquitina-Proteína Ligases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Actins); 0 (Cardiotonic Agents); 0 (Cytokines); 0 (Lipopolysaccharides); 0 (Muscle Proteins); 0 (Organometallic Compounds); 0 (Tripartite Motif Proteins); 0 (tricarbonylchloro(glycinato)ruthenium(II)); 7U1EE4V452 (Carbon Monoxide); EC 2.3.2.27 (Fbxo32 protein, rat); EC 2.3.2.27 (SKP Cullin F-Box Protein Ligases); EC 2.3.2.27 (Trim63 protein, rat); EC 2.3.2.27 (Ubiquitin-Protein Ligases); EC 3.6.1.- (Cardiac Myosins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


  9 / 39037 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28448877
[Au] Autor:Roy S; Mohanty M; Pasayat S; Majumder S; Senthilguru K; Banerjee I; Reichelt M; Reuter H; Sinn E; Dinda R
[Ad] Endereço:Department of Chemistry, National Institute of Technology, Rourkela 769008, Odisha, India.
[Ti] Título:Synthesis, structure and cytotoxicity of a series of Dioxidomolybdenum(VI) complexes featuring Salan ligands.
[So] Source:J Inorg Biochem;172:110-121, 2017 Jul.
[Is] ISSN:1873-3344
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Seven hexacoordinated cis-dioxidomolybdenum(VI) complexes [MoO L ] (1-7) derived from various tetradentate diamino bis(phenolato) "salan" ligands, N,N'-dimethyl-N,N'-bis-(2-hydroxy-3-X-5-Y-6-Z-benzyl)-1,2-diaminoethane {(X=Br, Y=Me, Z=H (H L ); X=Me, YCl, Z=H (H L ); X= Pr, Y=Cl, Z=Me (H L )} and N,N'-bis-(2-hydroxy-3-X-5-Y-6-Z-benzyl)-1,2-diaminopropane {(X=Y= Bu, Z=H (H L ); X=Y=Me, Z=H (H L ); X= Pr, YCl, Z=Me (H L ); X=Y=Br, Z=H (H L )} containing O-N donor atoms, have been isolated and structurally characterized. The formation of cis-dioxidomolybdenum(VI) complexes was confirmed by elemental analysis, IR, UV-vis and NMR spectroscopy, ESI-MS and cyclic voltammetry. X-ray crystallography showed the O N donor set to define an octahedral geometry in each case. The complexes (1-7) were tested for their in vitro antiproliferative activity against HT-29 and HeLa cancer cell line. IC values of the complexes in HT-29 follow the order 6<7<<1<2<5<<3<4 while the order was 6<7<5<1<<3<4<2 in HeLa cells. Some of the complexes proved to be as active as the clinical referred drugs, and the greater potency of 6 and 7 (IC values of 6 are 2.62 and 10.74µM and that of 7 is 11.79 and 30.48µM in HT-29 and HeLa cells, respectively) may be dependent on the substituents in the salan ligand environment coordinated to the metal.
[Mh] Termos MeSH primário: Ligantes
Molibdênio/química
Compostos Organometálicos
[Mh] Termos MeSH secundário: Proliferação Celular/efeitos dos fármacos
Cisplatino/química
Cisplatino/farmacologia
Cristalografia por Raios X
Células HT29
Células HeLa
Seres Humanos
Concentração Inibidora 50
Estrutura Molecular
Molibdênio/farmacologia
Compostos Organometálicos/síntese química
Compostos Organometálicos/química
Compostos Organometálicos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ligands); 0 (Organometallic Compounds); 81AH48963U (Molybdenum); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE


  10 / 39037 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27775192
[Au] Autor:Dasari S; Singh S; Sivakumar S; Patra AK
[Ad] Endereço:Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, 208016, Uttar Pradesh, India.
[Ti] Título:Dual-Sensitized Luminescent Europium(ΙΙΙ) and Terbium(ΙΙΙ) Complexes as Bioimaging and Light-Responsive Therapeutic Agents.
[So] Source:Chemistry;22(48):17387-17396, 2016 Nov 21.
[Is] ISSN:1521-3765
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Dual-photosensitized stable Eu and Tb complexes, namely [Eu(dpq)(tfnb) ] (1) and [Tb(dpq)(tfnb) ] (2), in which dpq=dipyrido[3,2-d:2',3'-f]quinoxaline and Htfnb=4,4,4-trifluoro-1-(2-napthyl)-1,3-butanedione, were designed as bioimaging and light-responsive therapeutic agents. Their X-ray structures, photophysical properties, biological interactions, photoinduced DNA damage, photocytotoxicity, and cellular uptake properties were studied. Discrete mononuclear complexes adopt an eight-coordinated {LnN O } distorted square antiprism geometry with bidentate N,N-donor dpq and O,O-donor tfnb ligands. The designed probes have the advantage of dual-sensitizing antennae (dpq, Htfnb) to modulate their desirable optical properties for cellular imaging and light-responsive intracellular damage. The remarkable photostability, absence of inner-sphere water (q<1), and longer excited-state lifetimes of the complexes make them suitable as cellular-imaging probes. The dpq T state is well located energetically to allow efficient energy transfer (ET) to the emissive D and D states of Eu and Tb . This leads to higher quantum yields (φ=0.15-0.20) in aqueous media and makes these compounds suitable cellular-imaging probes. The complexes display significant binding ability toward DNA and bovine serum albumin (K≈10 m ). They effectively cleave supercoiled DNA to its nicked circular form at λ=365 nm through photoredox pathways. The cellular internalization studies showed cytosolic and nuclear localization. The remarkable photocytotoxicity of these probes offers a strategy towards developing photoresponsive Ln probes as cellular-imaging and phototherapeutic agents.
[Mh] Termos MeSH primário: Dano ao DNA/efeitos dos fármacos
DNA/química
Európio/química
Substâncias Luminescentes/química
Compostos Organometálicos/química
Compostos Organometálicos/uso terapêutico
Fármacos Fotossensibilizantes/química
Soroalbumina Bovina/química
Térbio/química
[Mh] Termos MeSH secundário: Ligantes
Luminescência
Quinoxalinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ligands); 0 (Luminescent Agents); 0 (Organometallic Compounds); 0 (Photosensitizing Agents); 0 (Quinoxalines); 06SSF7P179 (Terbium); 27432CM55Q (Serum Albumin, Bovine); 444W947O8O (Europium); 9007-49-2 (DNA)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1002/chem.201603453



página 1 de 3904 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde