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[PMID]:28889024
[Au] Autor:Bjørklund G; Dadar M; Mutter J; Aaseth J
[Ad] Endereço:Council for Nutritional and Environmental Medicine, Toften 24, 8610 Mo i Rana, Norway. Electronic address: bjorklund@conem.org.
[Ti] Título:The toxicology of mercury: Current research and emerging trends.
[So] Source:Environ Res;159:545-554, 2017 11.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Mercury (Hg) is a persistent bio-accumulative toxic metal with unique physicochemical properties of public health concern since their natural and anthropogenic diffusions still induce high risk to human and environmental health. The goal of this review was to analyze scientific literature evaluating the role of global concerns over Hg exposure due to human exposure to ingestion of contaminated seafood (methyl-Hg) as well as elemental Hg levels of dental amalgam fillings (metallic Hg), vaccines (ethyl-Hg) and contaminated water and air (Hg chloride). Mercury has been recognized as a neurotoxicant as well as immunotoxic and designated by the World Health Organization as one of the ten most dangerous chemicals to public health. It has been shown that the half-life of inorganic Hg in human brains is several years to several decades. Mercury occurs in the environment under different chemical forms as elemental Hg (metallic), inorganic and organic Hg. Despite the raising understanding of the Hg toxicokinetics, there is still fully justified to further explore the emerging theories about its bioavailability and adverse effects in humans. In this review, we describe current research and emerging trends in Hg toxicity with the purpose of providing up-to-date information for a better understanding of the kinetics of this metal, presenting comprehensive knowledge on published data analyzing its metabolism, interaction with other metals, distribution, internal doses and targets, and reservoir organs.
[Mh] Termos MeSH primário: Exposição Ambiental
Compostos de Etilmercúrio/toxicidade
Cloreto de Mercúrio/toxicidade
Mercúrio/toxicidade
Compostos de Metilmercúrio/toxicidade
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Ethylmercury Compounds); 0 (Methylmercury Compounds); 53GH7MZT1R (Mercuric Chloride); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170911
[St] Status:MEDLINE


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[PMID]:27161558
[Au] Autor:Risher JF; Tucker P
[Ad] Endereço:Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, 1600 Clifton Road (MS F-58), Atlanta, GA, 30333, USA. jrisher@cdc.gov.
[Ti] Título:Alkyl Mercury-Induced Toxicity: Multiple Mechanisms of Action.
[So] Source:Rev Environ Contam Toxicol;240:105-149, 2017.
[Is] ISSN:0179-5953
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There are a number of mechanisms by which alkylmercury compounds cause toxic action in the body. Collectively, published studies reveal that there are some similarities between the mechanisms of the toxic action of the mono-alkyl mercury compounds methylmercury (MeHg) and ethylmercury (EtHg). This paper represents a summary of some of the studies regarding these mechanisms of action in order to facilitate the understanding of the many varied effects of alkylmercurials in the human body. The similarities in mechanisms of toxicity for MeHg and EtHg are presented and compared. The difference in manifested toxicity of MeHg and EtHg are likely the result of the differences in exposure, metabolism, and elimination from the body, rather than differences in mechanisms of action between the two.
[Mh] Termos MeSH primário: Compostos de Etilmercúrio/toxicidade
Compostos de Metilmercúrio/toxicidade
[Mh] Termos MeSH secundário: Cálcio/metabolismo
Glutationa/metabolismo
Seres Humanos
Neurotransmissores/metabolismo
Estresse Oxidativo/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Ethylmercury Compounds); 0 (Methylmercury Compounds); 0 (Neurotransmitter Agents); GAN16C9B8O (Glutathione); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160511
[St] Status:MEDLINE
[do] DOI:10.1007/398_2016_1


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[PMID]:26912563
[Au] Autor:Sommer YL; Ward CD; Pan Y; Caldwell KL; Jones RL
[Ad] Endereço:Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Inorganic and Radiation Analytical Toxicology Branch, 4770 Buford Highway NE, MS F-50, Atlanta, GA 30341, USA ysommer@cdc.gov.
[Ti] Título:Long-Term Stability of Inorganic, Methyl and Ethyl Mercury in Whole Blood: Effects of Storage Temperature and Time.
[So] Source:J Anal Toxicol;40(3):222-8, 2016 Apr.
[Is] ISSN:1945-2403
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, we evaluated the effect of temperature on the long-term stability of three mercury species in bovine blood. We used inductively coupled plasma mass spectrometry (ICP-MS) analysis to determine the concentrations of inorganic (iHg), methyl (MeHg) and ethyl (EtHg) mercury species in two blood pools stored at temperatures of -70, -20, 4, 23°C (room temperature) and 37°C. Over the course of a year, we analyzed aliquots of pooled specimens at time intervals of 1, 2, 4 and 6 weeks and 2, 4, 6, 8, 10 and 12 months. We applied a fixed-effects linear model, step-down pairwise comparison and coefficient of variation statistical analysis to examine the temperature and time effects on changes in mercury species concentrations. We observed several instances of statistically significant differences in mercury species concentrations between different temperatures and time points; however, with considerations of experimental factors (such as instrumental drift and sample preparation procedures), not all differences were scientifically important. We concluded that iHg, MeHg and EtHg species in bovine whole blood were stable at -70, -20, 4 and 23°C for 1 year, but blood samples stored at 37°C were stable for no more than 2 weeks.
[Mh] Termos MeSH primário: Compostos de Etilmercúrio/sangue
Mercúrio/sangue
Compostos de Metilmercúrio/sangue
[Mh] Termos MeSH secundário: Estabilidade de Medicamentos
Armazenamento de Medicamentos
Compostos de Etilmercúrio/química
Seres Humanos
Espectrometria de Massas
Mercúrio/química
Compostos de Metilmercúrio/química
Espectrofotometria Atômica
Temperatura Ambiente
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ethylmercury Compounds); 0 (Methylmercury Compounds); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160226
[St] Status:MEDLINE
[do] DOI:10.1093/jat/bkw007


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[PMID]:25701957
[Au] Autor:Haase H; Hebel S; Engelhardt G; Rink L
[Ad] Endereço:Department of Food Chemistry and Toxicology, Berlin Institute of Technology, Gustav-Meyer-Allee 25, 13355, Berlin, Germany. haase@tu-berlin.de.
[Ti] Título:Ethylmercury and Hg2+ induce the formation of neutrophil extracellular traps (NETs) by human neutrophil granulocytes.
[So] Source:Arch Toxicol;90(3):543-50, 2016 Mar.
[Is] ISSN:1432-0738
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Humans are exposed to different mercurial compounds from various sources, most frequently from dental fillings, preservatives in vaccines, or consumption of fish. Among other toxic effects, these substances interact with the immune system. In high doses, mercurials are immunosuppressive. However, lower doses of some mercurials stimulate the immune system, inducing different forms of autoimmunity, autoantibodies, and glomerulonephritis in rodents. Furthermore, some studies suggest a connection between mercury exposure and the occurrence of autoantibodies against nuclear components and granulocyte cytoplasmic proteins in humans. Still, the underlying mechanisms need to be clarified. The present study investigates the formation of neutrophil extracellular traps (NETs) in response to thimerosal and its metabolites ethyl mercury (EtHg), thiosalicylic acid, and mercuric ions (Hg(2+)). Only EtHg and Hg(2+) triggered NETosis. It was independent of PKC, ERK1/2, p38, and zinc signals and not affected by the NADPH oxidase inhibitor DPI. Instead, EtHg and Hg(2+) triggered NADPH oxidase-independent production of ROS, which are likely to be involved in mercurial-induced NET formation. This finding might help understanding the autoimmune potential of mercurial compounds. Some diseases, to which a connection with mercurials has been shown, such as Wegener's granulomatosis and systemic lupus erythematosus, are characterized by high prevalence of autoantibodies against neutrophil-specific auto-antigens. Externalization in the form of NETs may be a source for exposure to these self-antigens. In genetically susceptible individuals, this could be one step in the series of events leading to autoimmunity.
[Mh] Termos MeSH primário: Compostos de Etilmercúrio/toxicidade
Armadilhas Extracelulares/efeitos dos fármacos
Mercúrio/toxicidade
Neutrófilos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Células Cultivadas
Granulócitos/efeitos dos fármacos
Seres Humanos
Leucócitos/efeitos dos fármacos
NADPH Oxidases/metabolismo
Neutrófilos/metabolismo
Neutrófilos/patologia
Fosforilação/efeitos dos fármacos
Proteínas Quinases/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Salicilatos/toxicidade
Compostos de Sulfidrila/toxicidade
Timerosal/toxicidade
Zinco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ethylmercury Compounds); 0 (Reactive Oxygen Species); 0 (Salicylates); 0 (Sulfhydryl Compounds); 2225PI3MOV (Thimerosal); CIP6LXN5XW (thiosalicylic acid); EC 1.6.3.- (NADPH Oxidases); EC 2.7.- (Protein Kinases); FXS1BY2PGL (Mercury); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150223
[St] Status:MEDLINE
[do] DOI:10.1007/s00204-015-1484-y


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[PMID]:25981166
[Au] Autor:Rodrigues J; Branco V; Lu J; Holmgren A; Carvalho C
[Ad] Endereço:Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Portugal; Laboratory of Biochemistry, Faculty of Pharmacy, Central University of Venezuela, Venezuela. Electronic address: juanricardorodrigues@gmail.com.
[Ti] Título:Toxicological effects of thiomersal and ethylmercury: Inhibition of the thioredoxin system and NADP(+)-dependent dehydrogenases of the pentose phosphate pathway.
[So] Source:Toxicol Appl Pharmacol;286(3):216-23, 2015 Aug 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mercury (Hg) is a strong toxicant affecting mainly the central nervous, renal, cardiovascular and immune systems. Thiomersal (TM) is still in use in medical practice as a topical antiseptic and as a preservative in multiple dose vaccines, routinely given to young children in some developing countries, while other forms of mercury such as methylmercury represent an environmental and food hazard. The aim of the present study was to determine the effects of thiomersal (TM) and its breakdown product ethylmercury (EtHg) on the thioredoxin system and NADP(+)-dependent dehydrogenases of the pentose phosphate pathway. Results show that TM and EtHg inhibited the thioredoxin system enzymes in purified suspensions, being EtHg comparable to methylmercury (MeHg). Also, treatment of neuroblastoma and liver cells with TM or EtHg decreased cell viability (GI50: 1.5 to 20µM) and caused a significant (p<0.05) decrease in the overall activities of thioredoxin (Trx) and thioredoxin reductase (TrxR) in a concentration- and time-dependent manner in cell lysates. Compared to control, the activities of Trx and TrxR in neuroblastoma cells after EtHg incubation were reduced up to 60% and 80% respectively, whereas in hepatoma cells the reduction was almost 100%. In addition, the activities of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase were also significantly inhibited by all mercurials, with inhibition intensity of Hg(2+)>MeHg≈EtHg>TM (p<0.05). Cell incubation with sodium selenite alleviated the inhibitory effects on TrxR and glucose-6-phosphate dehydrogenase. Thus, the molecular mechanism of toxicity of TM and especially of its metabolite EtHg encompasses the blockage of the electrons from NADPH via the thioredoxin system.
[Mh] Termos MeSH primário: Compostos de Etilmercúrio/toxicidade
NADPH Desidrogenase/antagonistas & inibidores
Via de Pentose Fosfato/efeitos dos fármacos
Timerosal/toxicidade
Tiorredoxinas/antagonistas & inibidores
[Mh] Termos MeSH secundário: Sobrevivência Celular
Relação Dose-Resposta a Droga
Células Hep G2
Seres Humanos
NADPH Desidrogenase/metabolismo
Via de Pentose Fosfato/fisiologia
Tiorredoxinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ethylmercury Compounds); 2225PI3MOV (Thimerosal); 52500-60-4 (Thioredoxins); EC 1.6.99.1 (NADPH Dehydrogenase)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:150608
[Lr] Data última revisão:
150608
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150519
[St] Status:MEDLINE


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[PMID]:25769899
[Au] Autor:Rodríguez-Reino MP; Rodríguez-Fernández R; Peña-Vázquez E; Domínguez-González R; Bermejo-Barrera P; Moreda-Piñeiro A
[Ad] Endereço:Department of Analytical Chemistry, Nutrition and Bromatology, Faculty of Chemistry, University of Santiago de Compostela, Avenida das Ciencias, s/n, 15782 Santiago de Compostela, Spain.
[Ti] Título:Mercury speciation in seawater by liquid chromatography-inductively coupled plasma-mass spectrometry following solid phase extraction pre-concentration by using an ionic imprinted polymer based on methyl-mercury-phenobarbital interaction.
[So] Source:J Chromatogr A;1391:9-17, 2015 Apr 24.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Trace levels of inorganic mercury, methyl-mercury and ethyl-mercury have been assessed in seawater by high performance liquid chromatography (HPLC) hyphenated with inductively coupled plasma-mass spectrometry (ICP-MS) after solid phase extraction (SPE) pre-concentration with a novel synthesized ionic imprinted polymer. The adsorbent material was prepared by trapping a non-vinylated chelating ligand (phenobarbital) via imprinting of a ternary mixed ligand complex of the non-vinylated chelating agent, the template (methyl-mercury), and the vinyl ligand (metacrylic acid, MAA). Ethylene dimetacrylate (EDMA) and 2,2'-azobisisobutyronitrile (AIBN) were used as cross-linker and initiator reagents, respectively; and the precipitation polymerization technique was used in a porogen of acetonitrile/water (4:1). The best retention properties for methyl-mercury, inorganic mercury and ethyl-mercury species from seawater were obtained when loading 200 mL of sample adjusted to pH 8.0 and at a flow rate of 2.0 mL min(-1) on a column-packed with 200mg of the material. Quantitative mercury species recoveries were obtained using 4 mL of an eluting solution consisting of 0.8% (v/v) 2-mercaptoethanol and 20% (v/v) methanol (pH adjusted to 4.5) pumped at a flow rate of 2.0 mL min(-1). Mercury species separation was achieved on a Kinetex C18 column working under isocratic conditions (0.4% (v/v) 2-mercaptoethanol, 10% (v/v) methanol, pH 2.5, flow rate 0.7 mL min(-1)). ICP-MS detection was performed by monitoring the mercury mass to charge ratio of 202. The limits of quantification of the method were 11, 6.7, and 12 ng L(-1), for inorganic mercury, methyl-mercury and ethyl-mercury, respectively (pre-concentration factor of 50); whereas, analytical recoveries ranged from 96 to 106%. The developed method was successfully applied to several seawater samples from unpolluted areas.
[Mh] Termos MeSH primário: Quelantes/química
Compostos de Etilmercúrio/análise
Compostos de Mercúrio/análise
Compostos de Metilmercúrio/análise
Fenobarbital/química
Polimetil Metacrilato/química
Água do Mar/química
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão/métodos
Espectrometria de Massas/métodos
Compostos de Metilmercúrio/química
Impressão Molecular
Nitrilos
Extração em Fase Sólida
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chelating Agents); 0 (Ethylmercury Compounds); 0 (Mercury Compounds); 0 (Methylmercury Compounds); 0 (Nitriles); 0 (Water Pollutants, Chemical); 9011-14-7 (Polymethyl Methacrylate); FZ6PX8U5YB (azobis(isobutyronitrile)); YQE403BP4D (Phenobarbital)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:150330
[Lr] Data última revisão:
150330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150315
[St] Status:MEDLINE


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[PMID]:25280990
[Au] Autor:Acosta G; Spisso A; Fernández LP; Martinez LD; Pacheco PH; Gil RA
[Ad] Endereço:Instituto de Química de San Luis, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET, CCT-San Luis), Ejército de los Andes 950, San Luis D5700HHW, Argentina; Área de Gestión en Calidad y Salud, Facultad de Química Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y
[Ti] Título:Determination of thimerosal in pharmaceutical industry effluents and river waters by HPLC coupled to atomic fluorescence spectrometry through post-column UV-assisted vapor generation.
[So] Source:J Pharm Biomed Anal;106:79-84, 2015 Mar 15.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A high performance liquid chromatography coupled with atomic fluorescence spectrometry method for the determination of thimerosal (sodium ethylmercury thiosalicylate, C9H9HgNaO2S), ethylmercury, and inorganic mercury is proposed. Mercury vapor is generated by the post-column reduction of mercury species in formic acid media using UV-radiation. Thimerosal is quantitatively converted to Hg(II) followed by the reduction of Hg(II) to Hg(0). This method is applied to the determination of thimerosal (THM), ethylmercury (EtHg) and inorganic Hg in samples of a pharmaceutical industry effluent, and in waters of the San Luis River situated in the west side of San Luis city (Middle West, Argentine) where the effluents are dumped. The limit of detections, calculated on the basis of the 3σ criterion, where 0.09, 0.09 and 0.07 µg L(-1) for THM, EtHg(II) and for Hg(II), respectively. Linearity was attained from levels close to the detection limit up to at least 100 µg L(-1).
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Compostos de Etilmercúrio/análise
Espectrometria de Fluorescência/métodos
Timerosal/análise
[Mh] Termos MeSH secundário: Indústria Farmacêutica
Limite de Detecção
Mercúrio/análise
Rios
Espectrofotometria Atômica/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Ethylmercury Compounds); 2225PI3MOV (Thimerosal); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150304
[Lr] Data última revisão:
150304
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141005
[St] Status:MEDLINE


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[PMID]:24555642
[Au] Autor:Dórea JG; Marques RC; Abreu L
[Ad] Endereço:a Department of Nutrition , Universidade de Brasília , Brasília , Brazil.
[Ti] Título:Milestone achievement and neurodevelopment of rural Amazonian toddlers (12 to 24 months) with different methylmercury and ethylmercury exposure.
[So] Source:J Toxicol Environ Health A;77(1-3):1-13, 2014.
[Is] ISSN:1528-7394
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Neurological outcomes (Gesell development schedules [GDS]), age of walking, and age of talking were studied in 299 toddlers (12 to 24 mo) in relation to environmental (fish consumption and tin mining) exposure. Exposure to fish methylmercury (MeHg) consumption and iatrogenic ethylmercury (EtHg) in Thimerosal-containing vaccines (TCV) was quantified in toddlers from two rural villages (n = 91, Itapuã; n = 218, Bom Futuro) respectively populated by fishers and cassiterite miners. Median total hair Hg (HHg) concentrations of infants from Itapuã (3.5 µg/g) were significantly higher than those of infants from Bom Futuro (2.2 µg/g). Median EtHg exposure from TCV was also significantly higher in toddlers from Itapuã (137.5 µg) than in those from Bom Futuro (112.5 µg). There were no significant differences between groups for any of the Gesell schedules; however, there were proportionally more compromised toddlers (GDS < 70) in Itapuã than Bom Futuro. Median age of talking was not statistically different but median age of walking was significantly higher in Bom Futuro. In toddlers from both villages, of fishers and miners, HHg concentrations were significantly correlated with family fish consumption. A logistic regression model was applied to all infants after classification into two groups: above or below the median Gesell schedules. Overall, there was no distinctive pattern of neurodevelopment associated with either HHg or EtHg exposure; however, nutritional status was significantly associated with GDS. In conclusion, milestone achievement was delayed in toddlers from tin-ore mining communities. Despite significantly higher exposure to both forms of organic Hg (MeHg from maternal fish consumption, and EtHg from TCV) in toddlers from the fishing village, significant differences were seen only among the proportions of most severely affected toddlers (GDS < 70).
[Mh] Termos MeSH primário: Deficiências do Desenvolvimento/induzido quimicamente
Exposição Ambiental/efeitos adversos
Poluentes Ambientais/efeitos adversos
Compostos de Etilmercúrio/efeitos adversos
Compostos de Metilmercúrio/efeitos adversos
Saúde da População Rural
[Mh] Termos MeSH secundário: Brasil
Pré-Escolar
Estudos Transversais
Deficiências do Desenvolvimento/diagnóstico
Dieta/efeitos adversos
Inquéritos sobre Dietas
Exposição Ambiental/análise
Monitoramento Ambiental
Poluentes Ambientais/análise
Compostos de Etilmercúrio/análise
Feminino
Contaminação de Alimentos
Cabelo/química
Seres Humanos
Lactente
Transtornos do Desenvolvimento da Linguagem/induzido quimicamente
Transtornos do Desenvolvimento da Linguagem/diagnóstico
Modelos Logísticos
Masculino
Compostos de Metilmercúrio/análise
Mineração
Conservantes Farmacêuticos/efeitos adversos
Alimentos Marinhos/efeitos adversos
Timerosal/efeitos adversos
Estanho
Vacinas/efeitos adversos
Caminhada
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Ethylmercury Compounds); 0 (Methylmercury Compounds); 0 (Preservatives, Pharmaceutical); 0 (Vaccines); 2225PI3MOV (Thimerosal); 7440-31-5 (Tin)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:140221
[Lr] Data última revisão:
140221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140222
[St] Status:MEDLINE
[do] DOI:10.1080/15287394.2014.861335


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Malm, Olaf
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[PMID]:24486466
[Au] Autor:Marques RC; Bernardi JV; Dórea JG; de Fatima R Moreira M; Malm O
[Ad] Endereço:Federal University of Rio de Janeiro, Campus Macaé, CEP 27930-560 RJ, Brazil.
[Ti] Título:Perinatal multiple exposure to neurotoxic (lead, methylmercury, ethylmercury, and aluminum) substances and neurodevelopment at six and 24 months of age.
[So] Source:Environ Pollut;187:130-5, 2014 Apr.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We studied neurodevelopment in infants from two communities. Children living in the vicinity of tin-ore kilns and smelters - TOKS; n = 51) were compared to children from a fishing village (Itapuã; n = 45). Mean hair-Hg (HHg) concentrations were significantly higher in Itapuã children which received significantly (p = 0.0000001) less mean ethylmercury (88.6 µg) from Thimerosal-containing vaccines (TCV) than the TOKS children (120 µg). Breast-milk Pb concentrations were significantly higher in the TOKS mothers (p = 0.000017; 10.04 vs. 3.9 µg L(-1)). Bayley mental development index (MDI) and psychomotor development index (PDI) were statistically significant (respectively p < 0.0000001, p = 0.000007) lower for the TOKS children only at 24 months of age. Multivariate regression analysis showed that MDI was negatively affected by breast-milk Pb and by HHg. PDI was positively affected by breastfeeding and negatively affected by ethylmercury. Milestone achievements were negatively affected by breast-milk Pb (age of walking) and by HHg (age of talking).
[Mh] Termos MeSH primário: Alumínio/metabolismo
Compostos de Etilmercúrio/metabolismo
Chumbo/metabolismo
Exposição Materna/estatística & dados numéricos
Compostos de Metilmercúrio/metabolismo
Sistema Nervoso/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Adulto
Animais
Aleitamento Materno/estatística & dados numéricos
Pré-Escolar
Dieta/estatística & dados numéricos
Feminino
Contaminação de Alimentos/estatística & dados numéricos
Cabelo/metabolismo
Seres Humanos
Lactente
Masculino
Leite Humano/metabolismo
Mães
Análise Multivariada
Sistema Nervoso/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ethylmercury Compounds); 0 (Methylmercury Compounds); 2P299V784P (Lead); CPD4NFA903 (Aluminum)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:140224
[Lr] Data última revisão:
140224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140204
[St] Status:MEDLINE


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[PMID]:23522263
[Au] Autor:Kodamatani H; Tomiyasu T
[Ad] Endereço:Division of Earth and Environmental science, Graduate School of Science and Engineering, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065, Japan.
[Ti] Título:Selective determination method for measurement of methylmercury and ethylmercury in soil/sediment samples using high-performance liquid chromatography-chemiluminescence detection coupled with simple extraction technique.
[So] Source:J Chromatogr A;1288:155-9, 2013 May 03.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A method for the simultaneous determination of monomethylmercury (MeHg(+)) and monoethylmercury (EtHg(+)) in soil/sediment samples was developed. The method involves eluting mercury species from the soil/sediment samples using 5M HCl containing 5mM Pd(2+) and 0.1M Cu(2+) and then extracting MeHg(+) and EtHg(+) into toluene as chlorides. These alkylmercury chlorides are then back-extracted into an aqueous EDTA solution, creating EDTA complexes. Finally, an emetine-dithiocarbamate (emetineCS2) solution is added to the EDTA solution to form emetineCS2-alkylmercury complexes. EmetineCS2-MeHg and emetineCS2-EtHg were separated using reverse-phase HPLC and then detected by the chemiluminescence reaction with tris(2,2'-bipyridine)ruthenium(III). The MeHg(+) and EtHg(+) calibration curves, using the peak height, were linear from 0.5 to 20ng (as Hg). The detection limit was 0.16ng/g (analyzing 1g soil or sediment). The procedure was validated by analyzing a certified reference material (ERM CC580, estuarine sediment). The MeHg(+) concentration determined using the proposed method was in good agreement with the certified value, and EtHg(+) was detected in the reference material. A preliminary study of the relationship between environmental mercury concentrations and MeHg(+) production was performed.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Compostos de Etilmercúrio/análise
Compostos de Metilmercúrio/análise
Poluentes do Solo/análise
[Mh] Termos MeSH secundário: Fracionamento Químico
Cromatografia de Fase Reversa/métodos
Compostos de Etilmercúrio/química
Compostos de Etilmercúrio/isolamento & purificação
Sedimentos Geológicos/química
Medições Luminescentes
Compostos de Metilmercúrio/química
Compostos de Metilmercúrio/isolamento & purificação
Reprodutibilidade dos Testes
Solo/química
Poluentes do Solo/química
Poluentes do Solo/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ethylmercury Compounds); 0 (Methylmercury Compounds); 0 (Soil); 0 (Soil Pollutants)
[Em] Mês de entrada:1307
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130326
[St] Status:MEDLINE



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