Base de dados : MEDLINE
Pesquisa : D02.691.750.100.347.417 [Categoria DeCS]
Referências encontradas : 92 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 10 ir para página                        

  1 / 92 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27565891
[Au] Autor:Wang S; Lv Q; Yang Y; Guo LH; Wan B; Ren X; Zhang H
[Ad] Endereço:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P.O. Box 2871, 18 Shuangqing Road, Beijing 100085, China; College of Environmental Science and Engineering, Taiyuan University of Technology, Taiyuan 030024
[Ti] Título:Arginine decarboxylase: A novel biological target of mercury compounds identified in PC12 cells.
[So] Source:Biochem Pharmacol;118:109-120, 2016 Oct 15.
[Is] ISSN:1873-2968
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mercury compounds are well-known toxic environmental pollutants and potently induce severe neurotoxicological effects in human and experimental animals. Previous studies showed that one of the mechanisms of mercury compounds neurotoxicity arose from the over-activation of the N-methyl d-aspartate (NMDA)-type glutamate receptor induced by increased glutamate release. In this work, we aimed to investigate the molecular mechanisms of Hg compounds neurotoxicities by identifying their biological targets in cells. Firstly, the inhibitory effects of four Hg compounds, including three organic (methyl-, ethyl- and phenyl-mercury) and one inorganic (Hg ) Hg compounds, on the activity of arginine decarboxylase (ADC), a key enzyme in the central agmatinergic system, were evaluated. They were found to inhibit the ADC activity significantly with methylmercury (MeHg) being the strongest (IC =7.96nM). Furthermore, they showed remarkable inhibitory effects on ADC activity in PC12 cells (MeHg>EtHg>PhHg>HgCl ), and led to a marked loss in the level of agmatine, an endogenous neuromodulatory and neuroprotective agent that selectively blocks the activation of NMDA receptors. MeHg was detected in the immunoprecipitated ADC from the cells, providing unequivocal evidence for the direct binding of MeHg with ADC in the cell. Molecular dynamics simulation revealed that Hg compounds could form the coordination bond not only with cofactor PLP of ADC, but also with substrate arginine. Our finding indicated that MeHg could attenuate the neuroprotective effects of agmatine by the inhibition of ADC, a new cellular target of MeHg, which might be implicated in molecular mechanism of MeHg neurotoxicity.
[Mh] Termos MeSH primário: Carboxiliases/antagonistas & inibidores
Poluentes Ambientais/toxicidade
Inibidores Enzimáticos/toxicidade
Compostos de Metilmercúrio/toxicidade
Modelos Moleculares
Proteínas do Tecido Nervoso/antagonistas & inibidores
Neurônios/efeitos dos fármacos
[Mh] Termos MeSH secundário: Absorção Fisiológica
Agmatina/antagonistas & inibidores
Agmatina/metabolismo
Animais
Arginina/metabolismo
Sítios de Ligação
Biocatálise/efeitos dos fármacos
Carboxiliases/química
Carboxiliases/genética
Carboxiliases/metabolismo
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Complexos de Coordenação/antagonistas & inibidores
Complexos de Coordenação/química
Complexos de Coordenação/metabolismo
Descarboxilação/efeitos dos fármacos
Poluentes Ambientais/antagonistas & inibidores
Poluentes Ambientais/metabolismo
Inibidores Enzimáticos/química
Inibidores Enzimáticos/metabolismo
Cloreto Etilmercúrico/antagonistas & inibidores
Cloreto Etilmercúrico/metabolismo
Cloreto Etilmercúrico/toxicidade
Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos
Cloreto de Mercúrio/antagonistas & inibidores
Cloreto de Mercúrio/metabolismo
Cloreto de Mercúrio/toxicidade
Compostos de Metilmercúrio/antagonistas & inibidores
Compostos de Metilmercúrio/metabolismo
Simulação de Dinâmica Molecular
Proteínas do Tecido Nervoso/química
Proteínas do Tecido Nervoso/genética
Proteínas do Tecido Nervoso/metabolismo
Neurônios/enzimologia
Neurônios/metabolismo
Compostos de Fenilmercúrio/antagonistas & inibidores
Compostos de Fenilmercúrio/metabolismo
Compostos de Fenilmercúrio/toxicidade
Ratos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coordination Complexes); 0 (Environmental Pollutants); 0 (Enzyme Inhibitors); 0 (Methylmercury Compounds); 0 (Nerve Tissue Proteins); 0 (Phenylmercury Compounds); 53GH7MZT1R (Mercuric Chloride); 70J407ZL5Q (Agmatine); 94ZLA3W45F (Arginine); EC 4.1.1.- (Carboxy-Lyases); EC 4.1.1.19 (arginine decarboxylase); M04218TP6P (Ethylmercuric Chloride); RWZ4L3O1X0 (methylmercuric chloride); X0R4ES0U7Z (phenylmercuric chloride)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160828
[St] Status:MEDLINE


  2 / 92 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:24650080
[Au] Autor:Kountouras J; Deretzi G; Zavos C; Katsinelos P
[Ad] Endereço:Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Macedonia, Greece.
[Ti] Título:A possible impact of common worldwide environmental agents on the prognosis of critically ill cirrhotic patients.
[So] Source:Liver Int;34(7):1127-8, 2014 Aug.
[Is] ISSN:1478-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Cloreto Etilmercúrico/análogos & derivados
Potenciais Evocados/efeitos dos fármacos
Fungicidas Industriais/análogos & derivados
Córtex Somatossensorial/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Masculino
[Pt] Tipo de publicação:COMMENT; LETTER
[Nm] Nome de substância:
0 (Fungicides, Industrial); M04218TP6P (Ethylmercuric Chloride)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:140721
[Lr] Data última revisão:
140721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140322
[St] Status:MEDLINE
[do] DOI:10.1111/liv.12542


  3 / 92 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:23727015
[Au] Autor:Zimmermann LT; Santos DB; Naime AA; Leal RB; Dórea JG; Barbosa F; Aschner M; Rocha JB; Farina M
[Ad] Endereço:Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil. Electronic address: luciana.zimmermann@yahoo.com.br.
[Ti] Título:Comparative study on methyl- and ethylmercury-induced toxicity in C6 glioma cells and the potential role of LAT-1 in mediating mercurial-thiol complexes uptake.
[So] Source:Neurotoxicology;38:1-8, 2013 Sep.
[Is] ISSN:1872-9711
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Various forms of mercury possess different rates of absorption, metabolism and excretion, and consequently, toxicity. Methylmercury (MeHg) is a highly neurotoxic organic mercurial. Human exposure is mostly due to ingestion of contaminated fish. Ethylmercury (EtHg), another organic mercury compound, has received significant toxicological attention due to its presence in thimerosal-containing vaccines. This study was designed to compare the toxicities induced by MeHg and EtHg, as well as by their complexes with cysteine (MeHg-S-Cys and EtHg-S-Cys) in the C6 rat glioma cell line. MeHg and EtHg caused significant (p<0.0001) decreases in cellular viability when cells were treated during 30min with each mercurial following by a washing period of 24h (EC50 values of 4.83 and 5.05µM, respectively). Significant cytotoxicity (p<0.0001) was also observed when cells were treated under the same conditions with MeHg-S-Cys and EtHg-S-Cys, but the respective EC50 values were significantly increased (11.2 and 9.37µM). l-Methionine, a substrate for the l-type neutral amino acid carrier transport (LAT) system, significantly protected against the toxicities induced by both complexes (MeHg-S-Cys and EtHg-S-Cys). However, no protective effects of l-methionine were observed against MeHg and EtHg toxicities. Corroborating these findings, l-methionine significantly decreased mercurial uptake when cells were exposed to MeHg-S-Cys (p=0.028) and EtHg-S-Cys (p=0.023), but not to MeHg and EtHg. These results indicate that the uptake of MeHg-S-Cys and EtHg-S-Cys into C6 cells is mediated, at least in part, through the LAT system, but MeHg and EtHg enter C6 cells by mechanisms other than LAT system.
[Mh] Termos MeSH primário: Sistema L de Transporte de Aminoácidos/metabolismo
Cisteína/toxicidade
Cloreto Etilmercúrico/metabolismo
Cloreto Etilmercúrico/toxicidade
Glioma/patologia
Compostos de Metilmercúrio/metabolismo
Compostos de Metilmercúrio/toxicidade
[Mh] Termos MeSH secundário: Animais
Transporte Biológico/efeitos dos fármacos
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Complexos de Coordenação/antagonistas & inibidores
Complexos de Coordenação/química
Complexos de Coordenação/metabolismo
Complexos de Coordenação/toxicidade
Cisteína/química
Cloreto Etilmercúrico/antagonistas & inibidores
Cloreto Etilmercúrico/química
Glioma/metabolismo
Glutationa/efeitos dos fármacos
Glutationa/metabolismo
Hipocampo/metabolismo
Metionina/farmacologia
Compostos de Metilmercúrio/antagonistas & inibidores
Compostos de Metilmercúrio/química
Ratos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amino Acid Transport System L); 0 (Coordination Complexes); 0 (Methylmercury Compounds); AE28F7PNPL (Methionine); GAN16C9B8O (Glutathione); K848JZ4886 (Cysteine); M04218TP6P (Ethylmercuric Chloride); RWZ4L3O1X0 (methylmercuric chloride)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130604
[St] Status:MEDLINE


  4 / 92 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:19115550
[Au] Autor:Dórea JG
[Ti] Título:Community-directed risk assessment of mercury exposure: gold mining, fish, and unsuspected ethylmercury.
[So] Source:Rev Panam Salud Publica;24(3):220-1; author reply 221-2, 2008 Sep.
[Is] ISSN:1020-4989
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Serviços de Saúde Comunitária/organização & administração
Relações Comunidade-Instituição
Cloreto Etilmercúrico/efeitos adversos
Peixes
Ouro
Mercúrio/efeitos adversos
Mineração
[Mh] Termos MeSH secundário: Animais
Serviços de Saúde Comunitária/normas
Seres Humanos
Medição de Risco
[Pt] Tipo de publicação:COMMENT; LETTER
[Nm] Nome de substância:
7440-57-5 (Gold); FXS1BY2PGL (Mercury); M04218TP6P (Ethylmercuric Chloride)
[Em] Mês de entrada:0902
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090101
[St] Status:MEDLINE


  5 / 92 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:18524619
[Au] Autor:Guo Y; Chen L; Yang L; Wang Q
[Ad] Endereço:Department of Chemistry and the MOE Key Laboratory of Modern Analytical Sciences, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.
[Ti] Título:Counting sulfhydryls and disulfide bonds in peptides and proteins using mercurial ions as an MS-tag.
[So] Source:J Am Soc Mass Spectrom;19(8):1108-13, 2008 Aug.
[Is] ISSN:1044-0305
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Organic mercurial compounds are the most specific and sensitive reagents for reaction with the sulfhydryl groups (SHs) in peptides and proteins because of the strong mercury-sulfur affinity. Using the monofunctional organic mercury ion RHg(+) as a mass spectrometry (MS)-tag has the advantages of reacting with one sulfhydryl group, offering definite mass shift, and especially stable and characteristic nonradioactive isotopic distribution. Mass spectrometric analysis of derivatized sulfhydryls in peptides/proteins is thus an alternative for precisely counting the number of sulfhydryl groups and disulfide bonds (SS). Here the tags used include monomethylmercury chloride, monoethylmercury chloride, and 4-(hydroxymercuri) benzoic acid. The feasibility of this strategy is demonstrated using HPLC/ESI-MS to count SHs and SS in model peptides/proteins, i.e., glutathione, phytochelatins, lysozyme and beta-lactoglobulin, which contain increasing SHs and various SS linkages.
[Mh] Termos MeSH primário: Dissulfetos/química
Mercúrio/química
Peptídeos/química
Proteínas/química
Compostos de Sulfidrila/química
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Cloreto Etilmercúrico/química
Glutationa/química
Indicadores e Reagentes
Compostos de Metilmercúrio/química
Muramidase/química
Espectrometria de Massas por Ionização por Electrospray
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Disulfides); 0 (Indicators and Reagents); 0 (Methylmercury Compounds); 0 (Peptides); 0 (Proteins); 0 (Sulfhydryl Compounds); EC 3.2.1.17 (Muramidase); FXS1BY2PGL (Mercury); GAN16C9B8O (Glutathione); M04218TP6P (Ethylmercuric Chloride); RWZ4L3O1X0 (methylmercuric chloride)
[Em] Mês de entrada:0809
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080606
[St] Status:MEDLINE
[do] DOI:10.1016/j.jasms.2008.05.005


  6 / 92 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:16818529
[Au] Autor:Fombonne E; Zakarian R; Bennett A; Meng L; McLean-Heywood D
[Ad] Endereço:Department of Psychiatry, McGill University, Montréal Children's Hospital, 4018 Ste-Catherine West, Montreal, Quebec, Canada H3Z 1P2. eric.fombonne@mcgill.ca
[Ti] Título:Pervasive developmental disorders in Montreal, Quebec, Canada: prevalence and links with immunizations.
[So] Source:Pediatrics;118(1):e139-50, 2006 Jul.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The prevalence of pervasive developmental disorders has increased in recent years. Links with the measles component of the measles-mumps-rubella vaccine and the cumulative exposure to thimerosal through other vaccines have been postulated. OBJECTIVES: The purpose of this work was to estimate the pervasive developmental disorder prevalence in Montreal, Canada, in cohorts born from 1987 to 1998 and evaluate the relationship of trends in pervasive developmental disorder rates with: (1) changes in cumulative exposure to ethylmercury (thimerosal) occurring through modifications in the immunization schedule of young children and (2) trends in measles-mumps-rubella vaccination use rates and the introduction of a 2-measles-mumps-rubella dosing schedule during the study period. METHODS: We surveyed 27749 children born from 1987 to 1998 attending 55 schools from the largest Anglophone school board. Children with pervasive developmental disorders were identified by a special needs team. The cumulative exposure by age 2 years to thimerosal was calculated for 1987-1998 birth cohorts. Ethylmercury exposure ranged from medium (100-125 microg) from 1987 to 1991 to high (200-225 microg) from 1992 to 1995 to nil from 1996 onwards when thimerosal was entirely discontinued. Measles-mumps-rubella coverage for each birth cohort was estimated through surveys of vaccination rates. The immunization schedule included a measles-mumps-rubella single dose at 12 months of age up to 1995, and a second measles-mumps-rubella dose at 18 months of age was added on after 1996. RESULTS: We found 180 children (82.8% males) with a pervasive developmental disorder diagnosis who attended the surveyed schools, yielding a prevalence for pervasive developmental disorder of 64.9 per 10000. The prevalence for specific pervasive developmental disorder subtypes were, for autistic disorder: 21.6 of 10000; for pervasive developmental disorder not otherwise specified: 32.8 of 10000; and for Asperger syndrome: 10.1 of 10000. A statistically significant linear increase in pervasive developmental disorder prevalence was noted during the study period. The prevalence of pervasive developmental disorder in thimerosal-free birth cohorts was significantly higher than that in thimerosal-exposed cohorts (82.7 of 10000 vs 59.5 of 10000). Using logistic regression models of the prevalence data, we found no significant effect of thimerosal exposure used either as a continuous or a categorical variable. Thus, thimerosal exposure was unrelated to the increasing trend in pervasive developmental disorder prevalence. These results were robust when additional analyses were performed to address possible limitations because of the ecological nature of the data and to evaluate potential effects of misclassification on exposure or diagnosis. Measles-mumps-rubella vaccination coverage averaged 93% during the study interval with a statistically significant decreasing trend from 96.1% in the older birth cohorts (1988-89) to approximately 92.4% in younger birth cohorts (1996-1998). Thus, pervasive developmental disorder rates significantly increased when measles-mumps-rubella vaccination uptake rates significantly decreased. In addition, pervasive developmental disorder prevalence increased at the same rate before and after the introduction in 1996 of the second measles-mumps-rubella dose, suggesting no increased risk of pervasive developmental disorder associated with a 2-measles-mumps-rubella dosing schedule before age 2 years. Results held true when additional analyses were performed to test for the potential effects of misclassification on exposure or diagnostic status. Thus, no relationship was found between pervasive developmental disorder rates and 1- or 2-dose measles-mumps-rubella immunization schedule. CONCLUSIONS: The prevalence of pervasive developmental disorder in Montreal was high, increasing in recent birth cohorts as found in most countries. Factors accounting for the increase include a broadening of diagnostic concepts and criteria, increased awareness and, therefore, better identification of children with pervasive developmental disorders in communities and epidemiologic surveys, and improved access to services. The findings ruled out an association between pervasive developmental disorder and either high levels of ethylmercury exposure comparable with those experienced in the United States in the 1990s or 1- or 2-dose measles-mumps-rubella vaccinations.
[Mh] Termos MeSH primário: Transtornos Globais do Desenvolvimento Infantil/epidemiologia
Imunização/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Distribuição por Idade
Síndrome de Asperger/epidemiologia
Transtorno Autístico/epidemiologia
Criança
Transtornos Globais do Desenvolvimento Infantil/etiologia
Pré-Escolar
Cloreto Etilmercúrico
Feminino
Seres Humanos
Esquemas de Imunização
Modelos Logísticos
Masculino
Vacina contra Sarampo-Caxumba-Rubéola
Prevalência
Quebeque/epidemiologia
Distribuição por Sexo
Timerosal
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Measles-Mumps-Rubella Vaccine); 2225PI3MOV (Thimerosal); M04218TP6P (Ethylmercuric Chloride)
[Em] Mês de entrada:0608
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:060705
[St] Status:MEDLINE


  7 / 92 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:15501610
[Au] Autor:Harry GJ; Harris MW; Burka LT
[Ad] Endereço:Laboratory of Neurobiology, Neurotoxicology Group, National Institute of Environmental Health Sciences, P.O. Box 12233, MD C1-04, Research Triangle Park, NC 27709, USA. harry@niesh.nih.gov
[Ti] Título:Mercury concentrations in brain and kidney following ethylmercury, methylmercury and Thimerosal administration to neonatal mice.
[So] Source:Toxicol Lett;154(3):183-9, 2004 Dec 30.
[Is] ISSN:0378-4274
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The distribution of mercury to the brain following an injection of methylmercury (MeHg) or ethylmercury (EtHg) was examined in immature mice. Postnatal day (PND) 16 CD1 mice received MeHg chloride either by IM injection or by gavage. At 24 h and 7 days post-injection, total mercury concentrations were determined in blood, kidney, brain, and muscle by cold vapor atomic fluorescence spectrometry. At 24 h, an IM injection of MeHg chloride (17.4 microg) produced total mercury concentrations in the blood (6.2 +/- 0.9 microg/g), brain (5.6 +/- 1.3 microg; 0.6% delivered dose), and kidney (25.2 +/- 5.6 microg; 1.1%), approximately 30% of that obtained from oral administration (blood: 17.9 +/- 1.0 microg; brain: 16.1 +/- 1.2 microg, 1.5%; kidney: 64.9 +/- 6.3 microg, 2.7%). For comparison, PND 16 mice received an IM injection of concentrated dosing suspensions (2 microl dosing vol.) for EtHg chloride (6 microg) or Thimerosal (15.4 microg). For EtHg, approximately 0.39 +/- 0.06% of the injected mercury was detected in the brain and 3.5 +/- 0.6% in the kidney at 24 h. Thimerosal IM injection resulted in 0.22 +/- 0.04% in the brain, and 1.7 +/- 0.3% in the kidney. By 7 days, mercury levels decreased in the blood but were unchanged in the brain. An acute IM injection to adult mice of each suspension at a 10-fold higher dose resulted an average 0.1% mercury in the brain, and higher levels in the blood, kidney, and muscle as compared to the young. In immature mice, MeHg delivered via oral route of administration resulted in significantly greater tissue levels as compared to levels from IM injection. Comparisons of tissue distribution following IM administration suggest that an oral route of administration for mercury is not comparable to an IM delivery and that MeHg does not appear to be a good model for EtHg-containing compounds.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Cloreto Etilmercúrico/farmacocinética
Rim/metabolismo
Mercúrio/farmacocinética
Compostos de Metilmercúrio/farmacocinética
Timerosal/farmacocinética
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Cloreto Etilmercúrico/administração & dosagem
Injeções Intramusculares
Masculino
Compostos de Metilmercúrio/administração & dosagem
Camundongos
Timerosal/administração & dosagem
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Methylmercury Compounds); 2225PI3MOV (Thimerosal); FXS1BY2PGL (Mercury); M04218TP6P (Ethylmercuric Chloride); RWZ4L3O1X0 (methylmercuric chloride)
[Em] Mês de entrada:0503
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:041027
[St] Status:MEDLINE


  8 / 92 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:11178644
[Au] Autor:Thakur SC; Thakur SS; Banerjee S; Singh SP
[Ad] Endereço:Reproductive Biology Laboratory, Department of Zoology, DBS (Postgraduate) College, Dehradun-248 003, Uttar Pradesh, India.
[Ti] Título:Evaluation of adverse effect of Emisan-6 on male albino rats.
[So] Source:Bull Environ Contam Toxicol;66(3):306-12, 2001 Mar.
[Is] ISSN:0007-4861
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Cloreto Etilmercúrico/análogos & derivados
Cloreto Etilmercúrico/efeitos adversos
Fungicidas Industriais/efeitos adversos
Genitália Masculina/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Peso Corporal
Genitália Masculina/patologia
Masculino
Ratos
Reprodução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungicides, Industrial); 123-88-6 (neanthine); M04218TP6P (Ethylmercuric Chloride)
[Em] Mês de entrada:0105
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:010215
[St] Status:MEDLINE


  9 / 92 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:11080347
[Au] Autor:Thakur SC; Thakur SS; Singh SP
[Ad] Endereço:Hormone and Drug Research Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi-110 067, India.
[Ti] Título:Evaluation of the reproductive toxicity of Emisan 6 in female rats.
[So] Source:Bull Environ Contam Toxicol;66(1):132-8, 2001 Jan.
[Is] ISSN:0007-4861
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Estro/efeitos dos fármacos
Cloreto Etilmercúrico/análogos & derivados
Cloreto Etilmercúrico/toxicidade
Fungicidas Industriais/toxicidade
[Mh] Termos MeSH secundário: Administração Oral
Animais
Peso Corporal
Relação Dose-Resposta a Droga
Feminino
Genitália Feminina/patologia
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungicides, Industrial); 123-88-6 (neanthine); M04218TP6P (Ethylmercuric Chloride)
[Em] Mês de entrada:0105
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:001118
[St] Status:MEDLINE


  10 / 92 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:9928798
[Au] Autor:Santucci B; Cannistraci C; Cristaudo A; Camera E; Picardo M
[Ad] Endereço:San Gallicano Dermatological Institute, Rome, Italy.
[Ti] Título:Thimerosal positivities: patch testing to methylmercury chloride in subjects sensitive to ethylmercury chloride.
[So] Source:Contact Dermatitis;40(1):8-13, 1999 Jan.
[Is] ISSN:0105-1873
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this paper was to evaluate whether methylmercury chloride (MeHgCl) aq., when patch tested in a group of thimerosal-positive subjects reacting to ethylmercury chloride (EtHgCl), might be a reliable model for the better understanding of interactions between alkylmercury compounds and the skin. 19 out of 21 consecutive patients who previously had given positive patch-test reactions to both ethylmercury chloride 0.0165% eth.(EtHgCl, 0.615 mM) and MeHgCl 0.031% aq.(1.23 mM), and negative reactions to thiosalicylic acid 0.05% (3.24 mM) aq./eth. 50/50, were repatch tested to 8 microl of MeHgCl 0.031% aq. and to 8 microl of aq. solutions containing MeHgCl mixed with cysteine, glutathione, ZnSO4, MgSO4, MnSO4, ZnCl2, MgCl2 and MnCl2, respectively. The results showed that cysteine, glutathione and Zn(II) salts were able to abolish the positive reactions, demonstrating the rôle played by both thiol groups and Zn(II) itself. Patch tests concomitantly carried out in 16 out of 19 patients to 8 microl of aqueous MeHgCl and to 8 microl of aqueous solutions containing MeHgCl and MeHgCl mixed to fragment 56-61 of metallothionein I (MT I), MT I and MT II-Zn, respectively, revealed that all the MTs tested were able to reduce or to inhibit the reactions, demonstrating the effect of the thiol groups. Due to the close chemical similarities to EtHgCl and to its water solubility, MeHgCl seems to be a suitable model for evaluating the reactivity of alkylmercury compounds in the skin. We speculate that both EtHg- and MeHg-derivatives are xenobiotics with similar reactivity. However, the lack of clinical relevance of the reactions to both alkyl compounds lead us to conclude that, since environmental exposure does not seem to play a pivotal rôle, they probably have mostly to do with compounds included in in the standard series, and are elicited by reduced function of physiological SH chelators.
[Mh] Termos MeSH primário: Timerosal/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Cloretos/administração & dosagem
Cisteína/administração & dosagem
Dermatite Alérgica de Contato/diagnóstico
Dermatite Alérgica de Contato/etiologia
Cloreto Etilmercúrico/efeitos adversos
Feminino
Glutationa/administração & dosagem
Seres Humanos
Irritantes/efeitos adversos
Masculino
Compostos de Metilmercúrio/efeitos adversos
Compostos Organomercúricos
Testes do Emplastro
Compostos de Sulfidrila/efeitos adversos
Compostos de Zinco/administração & dosagem
Sulfato de Zinco/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chlorides); 0 (Irritants); 0 (Methylmercury Compounds); 0 (Organomercury Compounds); 0 (Sulfhydryl Compounds); 0 (Zinc Compounds); 2225PI3MOV (Thimerosal); 7733-02-0 (Zinc Sulfate); 86Q357L16B (zinc chloride); GAN16C9B8O (Glutathione); K848JZ4886 (Cysteine); M04218TP6P (Ethylmercuric Chloride); RWZ4L3O1X0 (methylmercuric chloride)
[Em] Mês de entrada:9903
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:990203
[St] Status:MEDLINE



página 1 de 10 ir para página                        
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde