Base de dados : MEDLINE
Pesquisa : D02.691.750.100.738 [Categoria DeCS]
Referências encontradas : 5302 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 531 ir para página                         

  1 / 5302 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29258870
[Au] Autor:Heimfarth L; Delgado J; Mingori MR; Moresco KS; Pureur RP; Gelain DP; Moreira JCF
[Ad] Endereço:Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, UFRGS, Porto Alegre, RS, Brazil. Electronic address: luahei@yahoo.com.br.
[Ti] Título:Delayed neurochemical effects of prenatal exposure to MeHg in the cerebellum of developing rats.
[So] Source:Toxicol Lett;284:161-169, 2018 Mar 01.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Human fetuses and neonates are particularly vulnerable to methylmercury (MeHg)-induced brain damage and are sensitive even to low exposure levels. Previous work of our group evidence that prenatal exposure to MeHg causes cognitive and behavioral alterations and disrupt hippocampus signaling. The current study aimed to investigate the effect of gestational exposure of rats to MeHg at low doses (1 or 2 mg/kg) on parameters of redox imbalance and key signaling pathways in the cerebellum of their offspring. Pregnant females received MeHg (treated group) or 0.9% saline water (control group) by gavage in alternated days from gestational day 5 (GD5) until parturition and analyzes were proceed in the cerebellum of 30-day-old pups. We found increased lipid peroxidation and protein carbonylation levels as well as decreased SH content in pups prenatally exposed to 2 mg/kg MeHg. In addition, misregulated SOD/catalase activities supported imbalanced redox equilibrium. We found decreased GSK3ß(Ser9) phosphorylation, suggesting activation of this enzyme and dephosphorylation/inhibition of ERK1/2 and JNK pathways. Increased PKAα catalytic subunit could be upstream of hyperphosphorylated c-Raf(Ser259) and downregulated MAPK pathway. In addition, we found raised levels of the Ca -dependent protein phosphatase 2 B (PP2B). We also found preserved immunohistochemical staining for both glial fibrillary acidic protein (GFAP) and NeuN in MeHg-exposed pups. Western blot analysis showed unaltered levels of BAX/BCL-XL, BAD/BCL-2 and active caspase 3. Together, these findings support absence of reactive astrocytes, neuronal damage and apoptotic cell death in the cerebellum of MeHg treated pups. The present study provides evidence that prenatal exposure to MeHg leads to later redox imbalance and disrupted signaling mechanisms in the cerebellum of 30-day-old pups potentially predisposing them to long-lasting neurological impairments in CNS.
[Mh] Termos MeSH primário: Cerebelo/efeitos dos fármacos
Poluentes Ambientais/toxicidade
Compostos de Metilmercúrio/toxicidade
Neurônios/efeitos dos fármacos
Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente
Efeitos Tardios da Exposição Pré-Natal/metabolismo
[Mh] Termos MeSH secundário: Animais
Cerebelo/crescimento & desenvolvimento
Cerebelo/metabolismo
Proteínas Quinases Dependentes de AMP Cíclico/metabolismo
Relação Dose-Resposta a Droga
Feminino
Glicogênio Sintase Quinase 3 beta/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Masculino
Neurônios/metabolismo
Oxirredução
Gravidez
Carbonilação Proteica/efeitos dos fármacos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Methylmercury Compounds); EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta); EC 2.7.11.1 (Gsk3b protein, rat); EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE


  2 / 5302 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29324759
[Au] Autor:Lackner J; Weiss M; Müller-Graf C; Greiner M
[Ad] Endereço:Department of Exposure, Federal Institute for Risk Assessment, Berlin, Germany.
[Ti] Título:Disease burden of methylmercury in the German birth cohort 2014.
[So] Source:PLoS One;13(1):e0190409, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aimed to estimate the disease burden of methylmercury for children born in Germany in the year 2014. Humans are mainly exposed to methylmercury when they eat fish or seafood. Prenatal methylmercury exposure is associated with IQ loss. To quantify this disease burden, we used Monte Carlo simulation to estimate the incidence of mild and severe mental retardation in children born to mothers who consume fish based on empirical data. Subsequently, we calculated the disease burden with the disability-adjusted life years (DALY)-method. DALYs combine mortality and morbidity in one measure and quantify the gap between an ideal situation, where the entire population experiences the standard life expectancy without disease and disability, and the actual situation. Thus, one DALY corresponds to the loss of one year of life in good health. The methylmercury-induced burden of disease for the German birth cohort 2014 was an average of 14,186 DALY (95% CI 12,915-15,440 DALY). A large majority of the DALYs was attributed to morbidity as compared to mortality. Of the total disease burden, 98% were attributed to mild mental retardation, which only leads to morbidity. The remaining disease burden was a result of severe mental retardation with equal proportions of premature death and morbidity.
[Mh] Termos MeSH primário: Compostos de Metilmercúrio/toxicidade
[Mh] Termos MeSH secundário: Carga Corporal (Radioterapia)
Pré-Escolar
Estudos de Coortes
Pessoas com Deficiência
Exposição Ambiental
Feminino
Alemanha
História do Século XXI
Seres Humanos
Deficiência Intelectual/induzido quimicamente
Masculino
Compostos de Metilmercúrio/farmacocinética
Método de Monte Carlo
Anos de Vida Ajustados por Qualidade de Vida
Alimentos Marinhos/análise
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Methylmercury Compounds)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190409


  3 / 5302 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28993027
[Au] Autor:Klapstein SJ; Ziegler SE; O'Driscoll NJ
[Ad] Endereço:Department of Earth Sciences, Memorial University of Newfoundland, St. John's, NL, Canada; Department of Earth and Environmental Science, Acadia University, Wolfville, NS, Canada. Electronic address: sara.klapstein@acadiau.ca.
[Ti] Título:Methylmercury photodemethylation is inhibited in lakes with high dissolved organic matter.
[So] Source:Environ Pollut;232:392-401, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Photodemethylation can be one of the primary processes for loss of neurotoxic methylmercury (MeHg) in freshwater lakes. Few studies have quantified seasonal variations in photodemethylation rate constants as a function of dissolved organic matter (DOM). We conducted 1-week irradiation experiments in two seasons to test for spatial and temporal differences in photodemethylation potential in temperate lake waters. Six study lakes in Kejimkujik National Park, Nova Scotia were sampled in summer and fall to include a range of naturally occurring DOM concentrations (4.4-13.4 and 3.9-16.4 mg C L , respectively). A negative linear relationship (R = 0.76, p = 0.01) was found between DOM concentration and photodemethylation rate constant across seasons, indicating that DOM is a strong predictor of MeHg photodemethylation independent of seasonal effects. The two highest carbon lakes (BDW and PEB) had significantly higher energy-normalized photodemethylation rate constants in summer compared to fall corresponding with lower DOM concentrations in summer relative to fall. Additionally, there were negative linear relationships between MeHg photodemethylation and DOM photomineralization (R s = 0.58-0.72) and DOM photobleaching (R s = 0.83-0.90). This key finding suggests that competition for photons within DOM structures may reduce the potential for MeHg photodemethylation in high carbon waters and that this relationship persists across seasons.
[Mh] Termos MeSH primário: Substâncias Húmicas/análise
Compostos de Metilmercúrio/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Carbono
Monitoramento Ambiental
Lagos/química
Compostos de Metilmercúrio/análise
Nova Escócia
Processos Fotoquímicos
Estações do Ano
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Humic Substances); 0 (Methylmercury Compounds); 0 (Water Pollutants, Chemical); 7440-44-0 (Carbon)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE


  4 / 5302 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29261810
[Au] Autor:Attoff K; Gliga A; Lundqvist J; Norinder U; Forsby A
[Ad] Endereço:Department of Neurochemistry, Stockholm University, Stockholm, Sweden.
[Ti] Título:Whole genome microarray analysis of neural progenitor C17.2 cells during differentiation and validation of 30 neural mRNA biomarkers for estimation of developmental neurotoxicity.
[So] Source:PLoS One;12(12):e0190066, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite its high relevance, developmental neurotoxicity (DNT) is one of the least studied forms of toxicity. Current guidelines for DNT testing are based on in vivo testing and they require extensive resources. Transcriptomic approaches using relevant in vitro models have been suggested as a useful tool for identifying possible DNT-generating compounds. In this study, we performed whole genome microarray analysis on the murine progenitor cell line C17.2 following 5 and 10 days of differentiation. We identified 30 genes that are strongly associated with neural differentiation. The C17.2 cell line can be differentiated into a co-culture of both neurons and neuroglial cells, giving a more relevant picture of the brain than using neuronal cells alone. Among the most highly upregulated genes were genes involved in neurogenesis (CHRDL1), axonal guidance (BMP4), neuronal connectivity (PLXDC2), axonogenesis (RTN4R) and astrocyte differentiation (S100B). The 30 biomarkers were further validated by exposure to non-cytotoxic concentrations of two DNT-inducing compounds (valproic acid and methylmercury) and one neurotoxic chemical possessing a possible DNT activity (acrylamide). Twenty-eight of the 30 biomarkers were altered by at least one of the neurotoxic substances, proving the importance of these biomarkers during differentiation. These results suggest that gene expression profiling using a predefined set of biomarkers could be used as a sensitive tool for initial DNT screening of chemicals. Using a predefined set of mRNA biomarkers, instead of the whole genome, makes this model affordable and high-throughput. The use of such models could help speed up the initial screening of substances, possibly indicating alerts that need to be further studied in more sophisticated models.
[Mh] Termos MeSH primário: Biomarcadores/metabolismo
Diferenciação Celular/genética
Genoma
Análise em Microsséries/métodos
Células-Tronco Neurais/citologia
Células-Tronco Neurais/metabolismo
Síndromes Neurotóxicas/genética
[Mh] Termos MeSH secundário: Acrilamida/toxicidade
Animais
Diferenciação Celular/efeitos dos fármacos
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/genética
Perfilação da Expressão Gênica
Regulação da Expressão Gênica/efeitos dos fármacos
Manitol/toxicidade
Compostos de Metilmercúrio/toxicidade
Camundongos
Células-Tronco Neurais/efeitos dos fármacos
Análise de Componente Principal
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Reprodutibilidade dos Testes
Fatores de Tempo
Ácido Valproico/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Methylmercury Compounds); 0 (RNA, Messenger); 20R035KLCI (Acrylamide); 3OWL53L36A (Mannitol); 614OI1Z5WI (Valproic Acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190066


  5 / 5302 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28464002
[Au] Autor:Carvan MJ; Kalluvila TA; Klingler RH; Larson JK; Pickens M; Mora-Zamorano FX; Connaughton VP; Sadler-Riggleman I; Beck D; Skinner MK
[Ad] Endereço:School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, United States of America.
[Ti] Título:Mercury-induced epigenetic transgenerational inheritance of abnormal neurobehavior is correlated with sperm epimutations in zebrafish.
[So] Source:PLoS One;12(5):e0176155, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Methylmercury (MeHg) is a ubiquitous environmental neurotoxicant, with human exposures predominantly resulting from fish consumption. Developmental exposure of zebrafish to MeHg is known to alter their neurobehavior. The current study investigated the direct exposure and transgenerational effects of MeHg, at tissue doses similar to those detected in exposed human populations, on sperm epimutations (i.e., differential DNA methylation regions [DMRs]) and neurobehavior (i.e., visual startle and spontaneous locomotion) in zebrafish, an established human health model. F0 generation embryos were exposed to MeHg (0, 1, 3, 10, 30, and 100 nM) for 24 hours ex vivo. F0 generation control and MeHg-exposed lineages were reared to adults and bred to yield the F1 generation, which was subsequently bred to the F2 generation. Direct exposure (F0 generation) and transgenerational actions (F2 generation) were then evaluated. Hyperactivity and visual deficit were observed in the unexposed descendants (F2 generation) of the MeHg-exposed lineage compared to control. An increase in F2 generation sperm epimutations was observed relative to the F0 generation. Investigation of the DMRs in the F2 generation MeHg-exposed lineage sperm revealed associated genes in the neuroactive ligand-receptor interaction and actin-cytoskeleton pathways being effected, which correlate to the observed neurobehavioral phenotypes. Developmental MeHg-induced epigenetic transgenerational inheritance of abnormal neurobehavior is correlated with sperm epimutations in F2 generation adult zebrafish. Therefore, mercury can promote the epigenetic transgenerational inheritance of disease in zebrafish, which significantly impacts its environmental health considerations in all species including humans.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos
Epigênese Genética/efeitos dos fármacos
Compostos de Metilmercúrio/farmacologia
[Mh] Termos MeSH secundário: Animais
Metilação de DNA/efeitos dos fármacos
Locomoção/efeitos dos fármacos
Masculino
Mutação/efeitos dos fármacos
Mutação/genética
Reflexo de Sobressalto
Retina/efeitos dos fármacos
Retina/fisiologia
Espermatozoides/efeitos dos fármacos
Peixe-Zebra/genética
Peixe-Zebra/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Methylmercury Compounds)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0176155


  6 / 5302 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27776932
[Au] Autor:Saravanabhavan G; Werry K; Walker M; Haines D; Malowany M; Khoury C
[Ad] Endereço:Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada. Electronic address: gurusankar.saravanabhavan@hc-sc.gc.ca.
[Ti] Título:Human biomonitoring reference values for metals and trace elements in blood and urine derived from the Canadian Health Measures Survey 2007-2013.
[So] Source:Int J Hyg Environ Health;220(2 Pt A):189-200, 2017 03.
[Is] ISSN:1618-131X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Human biomonitoring reference values are statistical estimates that indicate the upper margin of background exposure to a given chemical at a given time. Nationally representative human biomonitoring data on 176 chemicals, including several metals and trace elements, are available in Canada from 2007 to 2013 through the Canadian Health Measures Survey (CHMS). In this work, we used a systematic approach based on the reference interval concept proposed by the International Federation of Clinical Chemistry and Laboratory Medicine and the International Union of Pure and Applied Chemistry to derive reference values (RV s) for metals and trace elements. These RV s were derived for blood and urine matrices in the general Canadian population based on the latest biomonitoring data from the CHMS. Biomarkers were chosen based on specific selection criteria, including widespread detection in Canadians (≥66% detection rate). Reference populations were created for each biomarker by applying appropriate exclusion criteria. Age and sex were evaluated as possible partitioning criteria and separate RV s were derived for the sub-populations in cases where partitioning was deemed necessary. The RV s for metals and trace elements in blood ranged from 0.18µg/L for cadmium in young children aged 3-5 years to 7900µg/L for zinc in males aged 20-79 years. In the case of urinary biomarkers, the RV s ranged from 0.17µg/L for antimony in the total population aged 3-79 years to 1400mg/L for fluoride in adults aged 20-79 years. These RV s represent the first set of reference values for metals and trace elements in the general Canadian population. We compare the RV s from other countries where available and discuss factors that could influence such comparisons.
[Mh] Termos MeSH primário: Monitoramento Ambiental/estatística & dados numéricos
Poluentes Ambientais
Metais
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Arsênico/sangue
Arsênico/urina
Arsenicais/urina
Canadá
Criança
Pré-Escolar
Poluentes Ambientais/sangue
Poluentes Ambientais/urina
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Masculino
Metais/sangue
Metais/urina
Compostos de Metilmercúrio/sangue
Compostos de Metilmercúrio/normas
Meia-Idade
Valores de Referência
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Arsenicals); 0 (Environmental Pollutants); 0 (Metals); 0 (Methylmercury Compounds); N712M78A8G (Arsenic)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  7 / 5302 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28938205
[Au] Autor:Rothenberg SE; Jackson BP; Carly McCalla G; Donohue A; Emmons AM
[Ad] Endereço:Department of Environmental Health Sciences, University of South Carolina, Columbia, SC, USA; School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR, USA. Electronic address: sarah.rothenberg@oregonstate.edu.
[Ti] Título:Co-exposure to methylmercury and inorganic arsenic in baby rice cereals and rice-containing teething biscuits.
[So] Source:Environ Res;159:639-647, 2017 11.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Rice is an important dietary source for methylmercury (MeHg), a potent neurotoxin, and inorganic arsenic (As), a human carcinogen. Rice baby cereals are a dietary source of inorganic As; however, less is known concerning MeHg concentrations in rice baby cereals and rice teething biscuits. METHODS: MeHg concentrations were measured in 36 rice baby cereals, eight rice teething biscuits, and four baby cereals manufactured with oats/wheat (n = 48 total). Arsenic (As) species, including inorganic As, were determined in rice baby cereals and rice teething biscuits (n = 44/48), while total As was determined in all products (n = 48). RESULTS: Rice baby cereals and rice teething biscuits were on average 61 and 92 times higher in MeHg, respectively, and 9.4 and 4.7 times higher in total As, respectively, compared to wheat/oat baby cereals. For a 15-g serving of rice baby cereal, average MeHg intake was 0.0092µgday (range: 0.0013-0.034µgday ), while average inorganic As intake was 1.3µgday (range: 0.37-2.3µgday ). Inorganic As concentrations in two brands of rice baby cereal (n = 12/36 boxes of rice cereal) exceeded 100ng/g, the proposed action level from the U.S. Food and Drug Administration. Log MeHg and inorganic As concentrations in rice baby cereals were strongly, positively correlated (Pearson's rho = 0.60, p < 0.001, n = 36). CONCLUSIONS: Rice-containing baby cereals and teething biscuits were a dietary source of both MeHg and inorganic As. Studies concerning the cumulative impacts of MeHg and inorganic As on offspring development are warranted.
[Mh] Termos MeSH primário: Arsênico/análise
Arsenicais/análise
Grãos Comestíveis/química
Contaminação de Alimentos/análise
Alimentos Infantis/análise
Compostos de Metilmercúrio/análise
[Mh] Termos MeSH secundário: Seres Humanos
Lactente
Recém-Nascido
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Arsenicals); 0 (Methylmercury Compounds); N712M78A8G (Arsenic)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE


  8 / 5302 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28931792
[Au] Autor:Sakamoto M; Itai T; Murata K
[Ad] Endereço:Department of International Affairs and Environmental Research, National Institute for Minamata Disease.
[Ti] Título:Effects of Prenatal Methylmercury Exposure: From Minamata Disease to Environmental Health Studies.
[So] Source:Nihon Eiseigaku Zasshi;72(3):140-148, 2017.
[Is] ISSN:1882-6482
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Methylmercury, the causative agent of Minamata disease, can easily penetrate the brain, and adult-type Minamata disease patients showed neurological symptoms according to the brain regions where the neurons, mainly in the cerebrum and cerebellum, were damaged. In addition, fetuses are exposed to methylmercury via the placenta from maternal fish consumption, and high-level exposure to methylmercury causes damage to the brains of infants. Typical patients with fetal-type Minamata disease (i.e., serious poisoning caused by in utero exposure to methylmercury) were born during the period of severe methylmercury pollution in 1955-1959, although they showed no abnormality during gestation nor at delivery. However, they showed difficulties in head control, sitting, and walking, and showed disturbances in mental development, these symptoms that are similar to those of cerebral palsy, during the growth periods after birth. The impaired development of fetal-type Minamata disease patients was one of the most tragic and characteristic feature of Minamata disease. In this review, we first summarize 1) the effects of prenatal methylmercury exposure in Minamata disease. Then, we introduce the studies that were conducted mainly by Sakamoto et al. as follows: 2) a retrospective study on temporal and regional variations of methylmercury pollution in Minamata area using preserved umbilical cord methylmercury, 3) decline in male sex ratio observed in Minamata area, 4) characteristics of hand tremor and postural sway in fetal-type Minamata disease patients, 5) methylmercury transfer from mothers to infants during gestation and lactation (the role of placenta), 6) extrapolation studies using rat models on the effects of prenatal methylmercury exposure on the human brain, and 7) risks and benefits of fish consumption.
[Mh] Termos MeSH primário: Doenças Fetais/etiologia
Exposição Materna/efeitos adversos
Intoxicação do Sistema Nervoso por Mercúrio/etiologia
Compostos de Metilmercúrio/efeitos adversos
Compostos de Metilmercúrio/envenenamento
Efeitos Tardios da Exposição Pré-Natal
[Mh] Termos MeSH secundário: Animais
Encéfalo/metabolismo
Modelos Animais de Doenças
Feminino
Peixes
Seres Humanos
Japão
Troca Materno-Fetal
Intoxicação do Sistema Nervoso por Mercúrio/metabolismo
Compostos de Metilmercúrio/metabolismo
Placenta/metabolismo
Gravidez
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Methylmercury Compounds)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1265/jjh.72.140


  9 / 5302 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28889024
[Au] Autor:Bjørklund G; Dadar M; Mutter J; Aaseth J
[Ad] Endereço:Council for Nutritional and Environmental Medicine, Toften 24, 8610 Mo i Rana, Norway. Electronic address: bjorklund@conem.org.
[Ti] Título:The toxicology of mercury: Current research and emerging trends.
[So] Source:Environ Res;159:545-554, 2017 11.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Mercury (Hg) is a persistent bio-accumulative toxic metal with unique physicochemical properties of public health concern since their natural and anthropogenic diffusions still induce high risk to human and environmental health. The goal of this review was to analyze scientific literature evaluating the role of global concerns over Hg exposure due to human exposure to ingestion of contaminated seafood (methyl-Hg) as well as elemental Hg levels of dental amalgam fillings (metallic Hg), vaccines (ethyl-Hg) and contaminated water and air (Hg chloride). Mercury has been recognized as a neurotoxicant as well as immunotoxic and designated by the World Health Organization as one of the ten most dangerous chemicals to public health. It has been shown that the half-life of inorganic Hg in human brains is several years to several decades. Mercury occurs in the environment under different chemical forms as elemental Hg (metallic), inorganic and organic Hg. Despite the raising understanding of the Hg toxicokinetics, there is still fully justified to further explore the emerging theories about its bioavailability and adverse effects in humans. In this review, we describe current research and emerging trends in Hg toxicity with the purpose of providing up-to-date information for a better understanding of the kinetics of this metal, presenting comprehensive knowledge on published data analyzing its metabolism, interaction with other metals, distribution, internal doses and targets, and reservoir organs.
[Mh] Termos MeSH primário: Exposição Ambiental
Compostos de Etilmercúrio/toxicidade
Cloreto de Mercúrio/toxicidade
Mercúrio/toxicidade
Compostos de Metilmercúrio/toxicidade
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Ethylmercury Compounds); 0 (Methylmercury Compounds); 53GH7MZT1R (Mercuric Chloride); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170911
[St] Status:MEDLINE


  10 / 5302 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28837763
[Au] Autor:Ihara H; Kasamatsu S; Kitamura A; Nishimura A; Tsutsuki H; Ida T; Ishizaki K; Toyama T; Yoshida E; Abdul Hamid H; Jung M; Matsunaga T; Fujii S; Sawa T; Nishida M; Kumagai Y; Akaike T
[Ad] Endereço:Department of Biological Science, Graduate School of Science, Osaka Prefecture University , Osaka 599-8531, Japan.
[Ti] Título:Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells.
[So] Source:Chem Res Toxicol;30(9):1673-1684, 2017 Sep 18.
[Is] ISSN:1520-5010
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Electrophiles such as methylmercury (MeHg) affect cellular functions by covalent modification with endogenous thiols. Reactive persulfide species were recently reported to mediate antioxidant responses and redox signaling because of their strong nucleophilicity. In this study, we used MeHg as an environmental electrophile and found that exposure of cells to the exogenous electrophile elevated intracellular concentrations of the endogenous electrophilic molecule 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP), accompanied by depletion of reactive persulfide species and 8-SH-cGMP which is a metabolite of 8-nitro-cGMP. Exposure to MeHg also induced S-guanylation and activation of H-Ras followed by injury to cerebellar granule neurons. The electrophile-induced activation of redox signaling and the consequent cell damage were attenuated by pretreatment with a reactive persulfide species donor. In conclusion, exogenous electrophiles such as MeHg with strong electrophilicity impair the redox signaling regulatory mechanism, particularly of intracellular reactive persulfide species and therefore lead to cellular pathogenesis. Our results suggest that reactive persulfide species may be potential therapeutic targets for attenuating cell injury by electrophiles.
[Mh] Termos MeSH primário: Compostos de Metilmercúrio/química
Sulfetos/química
[Mh] Termos MeSH secundário: Animais
Anticorpos/imunologia
Sobrevivência Celular/efeitos dos fármacos
Cromatografia Líquida de Alta Pressão
GMP Cíclico/análogos & derivados
GMP Cíclico/química
GMP Cíclico/imunologia
GMP Cíclico/metabolismo
MAP Quinases Reguladas por Sinal Extracelular/genética
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Imuno-Histoquímica
Masculino
Compostos de Metilmercúrio/análise
Compostos de Metilmercúrio/toxicidade
Microscopia de Fluorescência
Naftoquinonas/química
Naftoquinonas/toxicidade
Óxido Nítrico/análise
Oxirredução
Células PC12
Ratos
Ratos Wistar
Espécies Reativas de Oxigênio/análise
Espécies Reativas de Oxigênio/metabolismo
Transdução de Sinais/efeitos dos fármacos
Espectrometria de Massas por Ionização por Electrospray
Sulfetos/farmacologia
Proteínas ras/genética
Proteínas ras/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (8-nitroguanosine 3',5'-cyclic monophosphate); 0 (Antibodies); 0 (Methylmercury Compounds); 0 (Naphthoquinones); 0 (Reactive Oxygen Species); 0 (Sulfides); 0 (persulfides); 31C4KY9ESH (Nitric Oxide); 804K62F61Q (1,2-naphthoquinone); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); EC 3.6.5.2 (ras Proteins); H2D2X058MU (Cyclic GMP)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.1021/acs.chemrestox.7b00120



página 1 de 531 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde