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[PMID]:28986082
[Au] Autor:Laranjeiro F; Sánchez-Marín P; Oliveira IB; Galante-Oliveira S; Barroso C
[Ad] Endereço:Biology Department and CESAM, University of Aveiro, Campus de Santiago, 3810-193, Aveiro, Portugal. Electronic address: flaranjeiro@ua.pt.
[Ti] Título:Fifteen years of imposex and tributyltin pollution monitoring along the Portuguese coast.
[So] Source:Environ Pollut;232:411-421, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:IMO's Anti-Fouling Systems convention banned the use of organotin-based antifouling systems in 2008 as the ultimate effort to stop tributyltin (TBT) inputs into the marine environment. One of the hazardous effects of TBT is imposex (the superimposition of male sexual characters onto gastropod females), a phenomenon that may cause female sterility and the gastropod populations decline. Despite previous European Union legislation had already been shown effective in reducing the imposex levels along the Portuguese coast, this study intends to confirm these decreasing trends after 2008 and describe the global evolution in the last 15 years. Imposex levels were assessed in two bioindicators - the dog-whelk Nucella lapillus and the netted-whelk Nassarius reticulatus (Gastropoda, Prosobranchia) - in 2011 and 2014, and the results were compared with previous years. Both species showed progressive decreasing trends in imposex levels over the last 15 years; median values of the vas deferens sequence index (VDSI) fell from 3.96 to 0.78 in N. lapillus and from 3.39 to 0.29 in N. reticulatus. The temporal/spatial evolution of imposex suggests an apparent shift of TBT hotspots, being now restricted to fishing ports and marinas in detriment of large commercial harbours where TBT levels fell rapidly. Butyltins were measured in the whole tissues of N. lapillus females collected in 2014: monobutyltin (MBT) varied from < DL (detection limit: 1 ng Sn/g) to 13 ng Sn/g dw, dibutyltin (DBT) from 2.2 to 27 ng Sn/g dw and TBT from 1.5 to 55 ng Sn/g dw. Although TBT body burden has declined over time, the butyltin degradation index ([MBT]+[DBT])/[TBT] exhibited values < 1 in c. a. 90% of the sites assessed, suggesting that recent TBT inputs are still widespread in the Portuguese coast eventually due to illegal use of TBT antifouling systems and TBT desorption from sediments.
[Mh] Termos MeSH primário: Gastrópodes/fisiologia
Moluscos/fisiologia
Compostos de Trialquitina/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Carga Corporal (Radioterapia)
Monitoramento Ambiental/métodos
Feminino
Masculino
Moluscos/metabolismo
Compostos Orgânicos de Estanho/toxicidade
Portugal
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organotin Compounds); 0 (Trialkyltin Compounds); 0 (Water Pollutants, Chemical); 0 (mono-n-butyltin); 1002-53-5 (di-n-butyltin); 4XDX163P3D (tributyltin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171008
[St] Status:MEDLINE


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[PMID]:28780455
[Au] Autor:Nath M; Mridula; Kumari R
[Ad] Endereço:Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India.. Electronic address: malanfcy@iitr.ernet.in.
[Ti] Título:Microwave-assisted synthesis of mixed ligands organotin(IV) complexes of 1,10-phenanthroline and l-proline: Physicochemical characterization, DFT calculations, chemotherapeutic potential validation by in vitro DNA binding and nuclease activity.
[So] Source:J Photochem Photobiol B;174:182-194, 2017 Sep.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Diorganotin(IV) and triphenyltin(IV) derivatives of L-proline (HPro) having general formula R Sn(Pro) (R=n-Bu (1), Ph (2)) and Ph Sn(Pro) (3), respectively, and the mixed ligands di-/triorganotin(IV) derivatives of L-proline and 1,10-phenanthroline (phen) with general formula [R Sn(Pro)(Phen)Cl] and [R Sn(Pro)(Phen)] (where R=Me (4 and 7), n-Bu (5 and 8), Ph (6 and 9)), respectively, have been synthesized by microwave-assisted method and characterized by elemental analysis, IR, NMR ( H, C and Sn) and DART-mass spectral studies. The results suggest bicapped tetrahedron or a skew trapezoidal-bipyramid geometry for R Sn(Pro) , a distorted tetrahedral geometry for Ph Sn(Pro) and a distorted octahedral geometry for [R Sn(Pro)(Phen)Cl] and [Ph Sn(Pro)(Phen)] around the Sn atom, and the same has been validated by density functional theory calculations (DFT). In vitro DNA binding studies of 1-9 have been investigated by UV-Vis, fluorescence and circular dichroism titrations, viscosity and DNA melting experiments. The observed hypochromic shift in UV-Vis and fluorescence studies evidenced a partial intercalative mode of binding of complexes to CT-DNA. The binding affinity and quenching ability have been quantified in terms of intrinsic binding constant (K ) and Stern-Volmer quenching constant (Ksv). The determined values suggest that di- and triorganotin(IV) derivatives of L-proline possess lesser affinity to bind with CT-DNA in comparison to the mixed ligands di-/triorganotin(IV) derivatives of L-proline and 1,10-phenanthroline. The partial intercalative mode of binding of these complexes with CT DNA has also been supported by a change in the viscosity and melting point of DNA as well as a change in the intensity of positive and negative bands in circular dichroism spectra. The cleavage studies by agarose gel electrophoresis indicate effective cleavage of supercoiled plasmid DNA into its nicked form by all the complexes and even to its linear form in presence of 9.
[Mh] Termos MeSH primário: DNA/metabolismo
Desoxirribonucleases/metabolismo
Micro-Ondas
Compostos Orgânicos de Estanho/química
Compostos Orgânicos de Estanho/metabolismo
Fenantrolinas/química
Prolina/química
[Mh] Termos MeSH secundário: Fenômenos Químicos
Técnicas de Química Sintética
DNA/química
Ligantes
Modelos Moleculares
Conformação Molecular
Desnaturação de Ácido Nucleico
Compostos Orgânicos de Estanho/síntese química
Compostos Orgânicos de Estanho/farmacologia
Teoria Quântica
Temperatura de Transição
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ligands); 0 (Organotin Compounds); 0 (Phenanthrolines); 9007-49-2 (DNA); 9DLQ4CIU6V (Proline); EC 3.1.- (Deoxyribonucleases); W4X6ZO7939 (1,10-phenanthroline)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170807
[St] Status:MEDLINE


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[PMID]:28753292
[Au] Autor:Shibahara O; Watanabe M; Yamada S; Akehi M; Sasaki T; Akahoshi A; Hanada T; Hirano H; Nakatani S; Nishioka H; Takeuchi Y; Kakuta H
[Ad] Endereço:Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , 1-1-1, Tsushima-Naka, Kita-Ku, Okayama 700-8530, Japan.
[Ti] Título:Synthesis of C-Labeled RXR Partial Agonist 1-[(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino]benzotriazole-5-carboxylic Acid (CBt-PMN) by Direct [ C]Carbon Dioxide Fixation via Organolithiation of Trialkyltin Precursor and PET Imaging Thereof.
[So] Source:J Med Chem;60(16):7139-7145, 2017 Aug 24.
[Is] ISSN:1520-4804
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The retinoid X receptor (RXR) partial agonist 1-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino]benzotriazole-5-carboxylic acid (1; CBt-PMN, E = 75%, EC = 143 nM) is a candidate for treatment of central nervous system (CNS) diseases such as Alzheimer's and Parkinson's diseases based on reports that RXR-full agonist 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) shows therapeutic effects on these disease in rodent models. Here, we synthesized carbon-11-labeled ([ C]1) as a tracer for positron emission tomography (PET) and used it in a PET imaging study to examine the brain uptake and biodistribution of 1. We found that CO fixation after tin-lithium exchange at -20 °C afforded [ C]1. This methodology may also be useful for synthesizing CO H-PET tracer derivatives of other compounds bearing π-rich heterocyclic rings. A PET/CT imaging study of [ C]1 in mice indicated 1 is distributed to the brain and is thus a candidate for treatment of CNS diseases.
[Mh] Termos MeSH primário: Compostos Radiofarmacêuticos/síntese química
Compostos Radiofarmacêuticos/farmacologia
Receptores X Retinoide/agonistas
Tetra-Hidronaftalenos/síntese química
Tetra-Hidronaftalenos/farmacologia
Triazóis/síntese química
Triazóis/farmacologia
[Mh] Termos MeSH secundário: Animais
Autorradiografia
Encéfalo/diagnóstico por imagem
Encéfalo/metabolismo
Dióxido de Carbono/química
Radioisótopos de Carbono
Agonismo Parcial de Drogas
Lítio/química
Masculino
Camundongos Endogâmicos ICR
Compostos Orgânicos de Estanho/química
Tomografia por Emissão de Pósitrons
Compostos Radiofarmacêuticos/administração & dosagem
Tetra-Hidronaftalenos/administração & dosagem
Triazóis/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (1-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino)benzotriazole-5-carboxylic acid); 0 (Carbon Radioisotopes); 0 (Organotin Compounds); 0 (Radiopharmaceuticals); 0 (Retinoid X Receptors); 0 (Tetrahydronaphthalenes); 0 (Triazoles); 142M471B3J (Carbon Dioxide); 9FN79X2M3F (Lithium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jmedchem.7b00817


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[PMID]:28709983
[Au] Autor:Hunakova L; Brtko J
[Ad] Endereço:Cancer Research Institute, BMC, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovak Republic. Electronic address: exonhun@savba.sk.
[Ti] Título:Sn- and Ge- triorganometallics exert different cytotoxicity and modulation of migration in triple-negative breast cancer cell line MDA-MB-231.
[So] Source:Toxicol Lett;279:16-21, 2017 Sep 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Among a variety of metal containing organic compounds, tin derivatives are enjoying an increasing interest and appear to be very promising as potential drug candidates. We studied eight organometallic derivatives, nuclear retinoid X receptor (RXR) ligands and two germanium containing derivates that do not serve as RXR ligands. Tributylgermanium chloride (TBGe) and triphenylgermanium chloride (TPGe) did not inhibit growth of human triple negative MDA-MB-231 breast cancer cells. On the other hand, the tributyltin derivatives were highly, the triphenyltin derivatives less cytotoxic, both groups with IC values of nanomolar range. All trialkyltin derivatives (tributyltin chloride, tributyltin bromide, tributyltin iodide, tributyltin hydride) and three triaryltin derivatives (triphenyltin chloride, triphenyltin hydride and triphenyltin hydroxide) caused caspase-3/7 dependent apoptosis. Those derivatives that showed no or weak cytotoxicity, TBGe, TPGe, and triphenyltin acetate, we found to reduce migration of tested triple negative breast cancer cells.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Movimento Celular/efeitos dos fármacos
Compostos Organometálicos/farmacologia
Compostos Orgânicos de Estanho/farmacologia
Neoplasias de Mama Triplo Negativas/tratamento farmacológico
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Caspase 3/metabolismo
Caspase 7/metabolismo
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Feminino
Seres Humanos
Concentração Inibidora 50
Invasividade Neoplásica
Receptores X Retinoide/efeitos dos fármacos
Receptores X Retinoide/metabolismo
Transdução de Sinais/efeitos dos fármacos
Fatores de Tempo
Compostos de Trialquitina/farmacologia
Neoplasias de Mama Triplo Negativas/metabolismo
Neoplasias de Mama Triplo Negativas/patologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Organometallic Compounds); 0 (Organotin Compounds); 0 (Retinoid X Receptors); 0 (Trialkyltin Compounds); 10038-98-9 (germanium chloride); 4XDX163P3D (tributyltin); 95T92AGN0V (triphenyltin); EC 3.4.22.- (CASP3 protein, human); EC 3.4.22.- (CASP7 protein, human); EC 3.4.22.- (Caspase 3); EC 3.4.22.- (Caspase 7)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170716
[St] Status:MEDLINE


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[PMID]:28688342
[Au] Autor:Siewiera P; Rózalska S; Bernat P
[Ad] Endereço:Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland.
[Ti] Título:Estrogen-mediated protection of the organotin-degrading strain Metarhizium robertsii against oxidative stress promoted by monobutyltin.
[So] Source:Chemosphere;185:96-104, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dibutyltin (DBT) is a global pollutant characterized by pro-oxidative properties. The fungal strain Metarhizium robertsii can eliminate high levels of DBT efficiently. In this study, induction of oxidative stress as well as its alleviation through the application of natural estrogens during the elimination of DBT by M. robertsii were evaluated. During the first 24 h of incubation, the initial concentration of DBT (20 mg l ) was reduced to 3.1 mg l , with simultaneous formation of a major byproduct - monobutyltin (MBT). In the presence of estrone (E1) or 17ß-estradiol (E2), the amounts of dibutyltin residues in the fungal cultures were found to be approximately 2-fold higher compared to cultures without estrogens, which was associated with the simultaneous utilization of the compounds by cytochrome P450 enzymes. On the other hand, MBT levels were approximately 2.5 times lower in the fungal cultures with the addition of one of the estrogens. MBT (not DBT) promotes the generation of O , H O , and NO at levels 65.89 ± 18.08, 4.04 ± 3.62, and 27.92 ± 1.95, respectively. Superoxide dismutase and catalase activities did not show any response of the M. robertsii strain against the overproduction of superoxide anion and hydrogen peroxide. Application of E1 as well as E2 ensured non-enzymatic defense against nitrosative and oxidative stress through scavenging of nitrogen and oxygen reactive species, and limited their levels from 1.5-fold to 21-fold, depending on the used estrogen.
[Mh] Termos MeSH primário: Estrogênios/metabolismo
Metarhizium/fisiologia
Compostos Orgânicos de Estanho/toxicidade
[Mh] Termos MeSH secundário: Estradiol
Estrona
Peróxido de Hidrogênio
Metarhizium/metabolismo
Oxirredução
Estresse Oxidativo
Espécies Reativas de Oxigênio
Superóxido Dismutase
Superóxidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrogens); 0 (Organotin Compounds); 0 (Reactive Oxygen Species); 0 (mono-n-butyltin); 1002-53-5 (di-n-butyltin); 11062-77-4 (Superoxides); 2DI9HA706A (Estrone); 4TI98Z838E (Estradiol); BBX060AN9V (Hydrogen Peroxide); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170709
[St] Status:MEDLINE


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[PMID]:28558289
[Au] Autor:Xiao Y; Jiang J; Hu W; Zhao Y; Hu J
[Ad] Endereço:MOE Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, People's Republic of China.
[Ti] Título:Toxicity of triphenyltin on the development of retinal axons in zebrafish at low dose.
[So] Source:Aquat Toxicol;189:9-15, 2017 Aug.
[Is] ISSN:1879-1514
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The impacts of triphenyltin (TPT) on ecological health are of particular concern due to the unexpectedly high levels found in wild fish around the world. Here, zebrafish embryos were exposed to TPT via in ovo nano-injection to study its toxicity on the development of retinal axons in fish. Lipophilic dye labeling revealed obvious defects in retinal axon development in larvae with normally shaped eyes, with incidences of 0, 1.08%, 2.66%, 4.26%, and 6.85% observed in the control, 0.8, 4.0, 20.0, and 100ng TPT-Cl/g wet weight (ww) exposure groups, respectively, showing a dose-dependent increase. Since the lowest observable effective concentration of TPT to induce retinal axon development defects was 0.8ng TPT-Cl/g ww, which is lower than the concentrations in wild fish eggs, this defect would occur in wild fish larvae. Alterations in the expressions of pax6 and ephrinBs, which regulate the establishment of retinal polarity, were correlated with defect incidence. Expression levels of the CYP26A1 gene and protein were significantly up-regulated in all exposure groups compared with the control, which may lead to significant decreases in concentrations of all-trans retinoic acid (atRA). Such a disruption of RA metabolism would, at least partly, contribute to the incidence of developmental defects in retinal axons. This study is the first to report that TPT can interfere with development of retinal axons in fish at low dose.
[Mh] Termos MeSH primário: Axônios/efeitos dos fármacos
Desenvolvimento Embrionário/efeitos dos fármacos
Compostos Orgânicos de Estanho/toxicidade
Retina/efeitos dos fármacos
Poluentes Químicos da Água/toxicidade
Peixe-Zebra/embriologia
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Embrião não Mamífero/anormalidades
Embrião não Mamífero/efeitos dos fármacos
Desenvolvimento Embrionário/genética
Larva/efeitos dos fármacos
Retina/anormalidades
Retina/embriologia
Ácido Retinoico 4 Hidroxilase/genética
Regulação para Cima
Peixe-Zebra/anormalidades
Peixe-Zebra/genética
Proteínas de Peixe-Zebra/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organotin Compounds); 0 (Water Pollutants, Chemical); 0 (Zebrafish Proteins); 95T92AGN0V (triphenyltin); EC 1.14.14.1 (Retinoic Acid 4-Hydroxylase); EC 1.14.14.1 (cyp26a1 protein, zebrafish)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE


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[PMID]:28554018
[Au] Autor:Mahanty S; Raghav D; Rathinasamy K
[Ad] Endereço:School of Biotechnology, National Institute of Technology Calicut, Calicut, Kerala, India.
[Ti] Título:In vitro evaluation of the cytotoxic and bactericidal mechanism of the commonly used pesticide triphenyltin hydroxide.
[So] Source:Chemosphere;183:339-352, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Triphenyltin hydroxide (TPTH) is a widely used pesticide that is highly toxic to a variety of organisms including humans and a potential contender for the environmental pollutant. In the present study, the cytotoxic mechanism of TPTH on mammalian cells was analyzed using HeLa cells and the antibacterial activity was analyzed using B. subtilis and E. coli cells. TPTH inhibited the growth of HeLa cells with a half-maximal inhibitory concentration of 0.25 µM and induced mitotic arrest. Immunofluorescence microscopy analysis showed that TPTH caused strong depolymerization of interphase microtubules and spindle abnormality with the appearance of colchicine type mitosis and condensed chromosome. TPTH exhibited high affinity for tubulin with a dissociation constant of 2.3 µM and inhibited the in vitro microtubule assembly in the presence of glutamate as well as microtubule-associated proteins. Results from the molecular docking and in vitro experiments implied that TPTH may have an overlapping binding site with colchicine on tubulin with a distance of about 11 Å between them. TPTH also binds to DNA at the A-T rich region of the minor groove. The data presented in the study revealed that the toxicity of TPTH in mammalian cells is mediated through its interactions with DNA and its strong depolymerizing activity on tubulin. However, its antibacterial activity was not through FtsZ, the prokaryotic homolog of tubulin but perhaps through its interactions with DNA.
[Mh] Termos MeSH primário: Compostos Orgânicos de Estanho/toxicidade
[Mh] Termos MeSH secundário: Antibacterianos/metabolismo
Antibacterianos/toxicidade
Sítios de Ligação
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
DNA/metabolismo
Escherichia coli/efeitos dos fármacos
Células HeLa
Seres Humanos
Microtúbulos/efeitos dos fármacos
Mitose/efeitos dos fármacos
Compostos Orgânicos de Estanho/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Organotin Compounds); 9007-49-2 (DNA); KKL46V5313 (triphenyltin hydroxide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE


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[PMID]:28535483
[Au] Autor:André A; Ruivo R; Capitão A; Froufe E; Páscoa I; Costa Castro LF; Santos MM
[Ad] Endereço:CIMAR/CIIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos s/n, 4450-208, Matosinhos, Portugal; ICBAS - Institute of Biomedical Sciences Abel Salazar, University of Porto, Rua Jorge de Viterbo Ferreira 228, 4050-313, Porto, Portu
[Ti] Título:Cloning and functional characterization of a retinoid X receptor orthologue in Platynereis dumerilii: An evolutionary and toxicological perspective.
[So] Source:Chemosphere;182:753-761, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the present work we provide the first isolation and functional characterization of a RXR orthologue in an annelid species, the Platynereis dumerilii. Using an in vitro luciferase reporter assay we evaluated the annelid receptor ability to respond to ligand 9-cis-retinoic acid, TBT and TPT. Our results show that the annelid RXR responds to 9-cis-retinoic acid and to the organotins by activating reporter gene transcription. The findings suggest a conserved mode of action of the receptor in response to a common signaling molecule and modulation by organotin compounds between vertebrates and Lophotrochozoans.
[Mh] Termos MeSH primário: Poliquetos/metabolismo
Receptores X Retinoide/metabolismo
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
Regulação da Expressão Gênica/fisiologia
Ligantes
Compostos Orgânicos de Estanho
Receptores X Retinoide/genética
Ativação Transcricional/efeitos dos fármacos
Tretinoína/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ligands); 0 (Organotin Compounds); 0 (Retinoid X Receptors); 1UA8E65KDZ (alitretinoin); 5688UTC01R (Tretinoin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE


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[PMID]:28528410
[Au] Autor:Ohji M; Harino H
[Ad] Endereço:Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, 183-8509, Japan. ohji@cc.tuat.ac.jp.
[Ti] Título:Comparison of Toxicities of Metal Pyrithiones Including Their Degradation Compounds and Organotin Antifouling Biocides to the Japanese Killifish Oryzias latipes.
[So] Source:Arch Environ Contam Toxicol;73(2):285-293, 2017 Aug.
[Is] ISSN:1432-0703
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Japanese killifish Oryzias latipes were exposed to three levels (0, 1, and 10 µg l ) of copper pyrithione (CuPT ), zinc pyrithione (ZnPT ), six of their degradation products, and the organotin compounds tributyltin (TBT) and triphenyltin (TPT) for 48 h at 20 °C. All individual fish exposed to 1 and 10 µg l of CuPT or 10 µg l of ZnPT were dead within 12 h, respectively, and at 24 h the survival rate of the fish exposed to 1 µg l of ZnPT was 50%. All fish exposed to 10 µg l of ZnPT showed morphological abnormalities in the form of vertebral deformity. None of the fish exposed to six of the degradation products of PTs, TBT, and TPT died during a 48-h exposure period, but various biological effects were observed in the fish exposed to these chemicals: abnormalities of respiration and swimming behavior, and decreased hatchability. Our findings suggest that O. latipes has a higher ecological risk of CuPT and ZnPT exposure than of TBT and TPT exposure during their life history. Because these antifouling biocides have been used in both freshwater and marine environments, our results highlight these biocides' deleterious effects on the freshwater fish as well as marine fish, and they indicate freshwater and marine pollution.
[Mh] Termos MeSH primário: Desinfetantes/toxicidade
Metais/toxicidade
Piridinas/toxicidade
Tionas/toxicidade
Testes de Toxicidade
[Mh] Termos MeSH secundário: Animais
Compostos Organometálicos/toxicidade
Compostos Orgânicos de Estanho/toxicidade
Oryzias
Compostos de Trialquitina/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Disinfectants); 0 (Metals); 0 (Organometallic Compounds); 0 (Organotin Compounds); 0 (Pyridines); 0 (Thiones); 0 (Trialkyltin Compounds); 0 (copper pyrithione); 4XDX163P3D (tributyltin); 6GK82EC25D (pyrithione); 95T92AGN0V (triphenyltin); R953O2RHZ5 (pyrithione zinc)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170522
[St] Status:MEDLINE
[do] DOI:10.1007/s00244-017-0367-z


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Texto completo
[PMID]:28527383
[Au] Autor:Lutfi E; Riera-Heredia N; Córdoba M; Porte C; Gutiérrez J; Capilla E; Navarro I
[Ad] Endereço:Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Barcelona 08028, Spain.
[Ti] Título:Tributyltin and triphenyltin exposure promotes in vitro adipogenic differentiation but alters the adipocyte phenotype in rainbow trout.
[So] Source:Aquat Toxicol;188:148-158, 2017 Jul.
[Is] ISSN:1879-1514
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Numerous environmental pollutants have been identified as potential obesogenic compounds affecting endocrine signaling and lipid homeostasis. Among them, well-known organotins such as tributyltin (TBT) and triphenyltin (TPT), can be found in significant concentrations in aquatic environments. The aim of the present study was to investigate in vitro the effects of TBT and TPT on the development and lipid metabolism of rainbow trout (Onchorynchus mykiss) primary cultured adipocytes. Results showed that TBT and TPT induced lipid accumulation and slightly enhanced peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT enhancer binding protein alpha (C/EBPα) protein expression when compared to a control, both in the presence or absence of lipid mixture. However, the effects were higher when combined with lipid, and in the absence of it, the organotins did not cause complete mature adipocyte morphology. Regarding gene expression analyses, exposure to TBT and TPT caused an increase in fatty acid synthase (fasn) mRNA levels confirming the pro-adipogenic properties of these compounds. In addition, when added together with lipid, TBT and TPT significantly increased cebpa, tumor necrosis factor alpha (tnfa) and ATP-binding cassette transporter 1 (abca1) mRNA levels suggesting a synergistic effect. Overall, our data highlighted that TBT and TPT activate adipocyte differentiation in rainbow trout supporting an obesogenic role for these compounds, although by themselves they are not able to induce complete adipocyte development and maturation suggesting that these adipocytes might not be properly functional.
[Mh] Termos MeSH primário: Adipócitos/efeitos dos fármacos
Adipogenia/efeitos dos fármacos
Compostos Orgânicos de Estanho/toxicidade
Compostos de Trialquitina/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Transportadores de Cassetes de Ligação de ATP/genética
Animais
Proteína alfa Estimuladora de Ligação a CCAAT/metabolismo
Metabolismo dos Lipídeos/efeitos dos fármacos
Oncorhynchus mykiss/metabolismo
PPAR gama/metabolismo
Fenótipo
Fator de Necrose Tumoral alfa/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CCAAT-Enhancer-Binding Protein-alpha); 0 (Organotin Compounds); 0 (PPAR gamma); 0 (Trialkyltin Compounds); 0 (Tumor Necrosis Factor-alpha); 0 (Water Pollutants, Chemical); 4XDX163P3D (tributyltin); 95T92AGN0V (triphenyltin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170521
[St] Status:MEDLINE



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