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[PMID]:28934713
[Au] Autor:Cacciatore F; Boscolo Brusà R; Noventa S; Antonini C; Moschino V; Formalewicz M; Gion C; Berto D; Gabellini M; Marin MG
[Ad] Endereço:ISPRA - Institute for Environmental Protection and Research, Loc. Brondolo, 30015 Chioggia, Italy. Electronic address: federica.cacciatore@isprambiente.it.
[Ti] Título:Imposex levels and butyltin compounds (BTs) in Hexaplex trunculus (Linnaeus, 1758) from the northern Adriatic Sea (Italy): Ecological risk assessment before and after the ban.
[So] Source:Ecotoxicol Environ Saf;147:688-698, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to compare imposex and butyltin compounds (BTs) data, collected before and after the organotin ban in 2008, in order to assess temporal and spatial variation of the phenomenon, the decline of BT contamination, and the effects on Hexaplex trunculus population in the coastal area of the northern Adriatic Sea, close to the Venice Lagoon. Both in marine and in lagoon sites, the results obtained in 2013-2015 showed a significant decline in the incidence of imposex in respect to those from the 2002 survey. In 2002, lagoon samples exhibited Relative Penis Size Index (RPSI) higher than marine samples, whereas no differences were detected in the recent survey, when all RPSI values were below 0.6%. Vas Deference Sequence Index (VDSI) mean values were over 4 before the ban introduction and below this value after that, indicating more critical conditions for gastropod population in 2002 rather than in 2013-15. Percentage of sterile females was up to 69% in 2002, whilst in the more recent survey no sterile female was found. Range of BT concentrations in gastropods decreased from 252 to 579 to 16-31ng∑BT/g d.w. BT body burdens varied according to a gender dependant pattern, with higher concentrations observed in females than in males. A first attempt to propose a classification based on BT impact on H. trunculus, according to the Water Framework Directive, revealed that most sites were in Bad ecological status before the ban and attained a Poor/Moderate status after that.
[Mh] Termos MeSH primário: Transtornos do Desenvolvimento Sexual/induzido quimicamente
Monitoramento Ambiental/métodos
Gastrópodes/efeitos dos fármacos
Compostos de Trialquitina/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Carga Corporal (Radioterapia)
Feminino
Gastrópodes/metabolismo
Itália
Masculino
Mar Mediterrâneo
Medição de Risco
Água do Mar/química
Compostos de Trialquitina/metabolismo
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Trialkyltin Compounds); 0 (Water Pollutants, Chemical); 4XDX163P3D (tributyltin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE


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[PMID]:29191790
[Au] Autor:Scheider J; Afonso-Grunz F; Jessl L; Hoffmeier K; Winter P; Oehlmann J
[Ad] Endereço:Goethe University Frankfurt am Main, Institute for Ecology, Evolution and Diversity, Department Aquatic Ecotoxicology, Max-von-Laue-Str. 13, 60438, Frankfurt/M., Germany. Electronic address: J.Scheider@bio.uni-frankfurt.de.
[Ti] Título:Morphological and transcriptomic effects of endocrine modulators on the gonadal differentiation of chicken embryos: The case of tributyltin (TBT).
[So] Source:Toxicol Lett;284:143-151, 2018 Mar 01.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Morphological malformations induced by tributyltin (TBT) exposure during embryonic development have already been characterized in various taxonomic groups, but, nonetheless, the molecular processes underlying these changes remain obscure. The present study provides the first genome-wide screening for differentially expressed genes that are linked to morphological alterations of gonadal tissue from chicken embryos after exposure to TBT. We applied a single injection of TBT (between 0.5 and 30 pg as Sn/g egg) into incubated fertile eggs to simulate maternal transfer of the endocrine disruptive compound. Methyltestosterone (MT) served as a positive control (30 pg/g egg). After 19 days of incubation, structural features of the gonads as well as genome-wide gene expression profiles were assessed simultaneously. TBT induced significant morphological and histological malformations of gonadal tissue from female embryos that show a virilization of the ovaries. This phenotypical virilization was mirrored by altered expression profiles of sex-dependent genes. Among these are several transcription and growth factors (e.g. FGF12, CTCF, NFIB), whose altered expression might serve as a set of markers for early identification of endocrine active chemicals that affect embryonic development by transcriptome profiling without the need of elaborate histological analyses.
[Mh] Termos MeSH primário: Diferenciação Celular/efeitos dos fármacos
Desenvolvimento Embrionário/efeitos dos fármacos
Disruptores Endócrinos/toxicidade
Gônadas/efeitos dos fármacos
Transcriptoma/efeitos dos fármacos
Compostos de Trialquitina/toxicidade
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular/genética
Embrião de Galinha
Desenvolvimento Embrionário/genética
Feminino
Perfilação da Expressão Gênica
Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos
Estudo de Associação Genômica Ampla
Gônadas/embriologia
Gônadas/patologia
Masculino
Caracteres Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Endocrine Disruptors); 0 (Trialkyltin Compounds); 4XDX163P3D (tributyltin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE


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[PMID]:28986082
[Au] Autor:Laranjeiro F; Sánchez-Marín P; Oliveira IB; Galante-Oliveira S; Barroso C
[Ad] Endereço:Biology Department and CESAM, University of Aveiro, Campus de Santiago, 3810-193, Aveiro, Portugal. Electronic address: flaranjeiro@ua.pt.
[Ti] Título:Fifteen years of imposex and tributyltin pollution monitoring along the Portuguese coast.
[So] Source:Environ Pollut;232:411-421, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:IMO's Anti-Fouling Systems convention banned the use of organotin-based antifouling systems in 2008 as the ultimate effort to stop tributyltin (TBT) inputs into the marine environment. One of the hazardous effects of TBT is imposex (the superimposition of male sexual characters onto gastropod females), a phenomenon that may cause female sterility and the gastropod populations decline. Despite previous European Union legislation had already been shown effective in reducing the imposex levels along the Portuguese coast, this study intends to confirm these decreasing trends after 2008 and describe the global evolution in the last 15 years. Imposex levels were assessed in two bioindicators - the dog-whelk Nucella lapillus and the netted-whelk Nassarius reticulatus (Gastropoda, Prosobranchia) - in 2011 and 2014, and the results were compared with previous years. Both species showed progressive decreasing trends in imposex levels over the last 15 years; median values of the vas deferens sequence index (VDSI) fell from 3.96 to 0.78 in N. lapillus and from 3.39 to 0.29 in N. reticulatus. The temporal/spatial evolution of imposex suggests an apparent shift of TBT hotspots, being now restricted to fishing ports and marinas in detriment of large commercial harbours where TBT levels fell rapidly. Butyltins were measured in the whole tissues of N. lapillus females collected in 2014: monobutyltin (MBT) varied from < DL (detection limit: 1 ng Sn/g) to 13 ng Sn/g dw, dibutyltin (DBT) from 2.2 to 27 ng Sn/g dw and TBT from 1.5 to 55 ng Sn/g dw. Although TBT body burden has declined over time, the butyltin degradation index ([MBT]+[DBT])/[TBT] exhibited values < 1 in c. a. 90% of the sites assessed, suggesting that recent TBT inputs are still widespread in the Portuguese coast eventually due to illegal use of TBT antifouling systems and TBT desorption from sediments.
[Mh] Termos MeSH primário: Gastrópodes/fisiologia
Moluscos/fisiologia
Compostos de Trialquitina/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Carga Corporal (Radioterapia)
Monitoramento Ambiental/métodos
Feminino
Masculino
Moluscos/metabolismo
Compostos Orgânicos de Estanho/toxicidade
Portugal
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organotin Compounds); 0 (Trialkyltin Compounds); 0 (Water Pollutants, Chemical); 0 (mono-n-butyltin); 1002-53-5 (di-n-butyltin); 4XDX163P3D (tributyltin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171008
[St] Status:MEDLINE


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[PMID]:29289284
[Au] Autor:Kopp R; Martínez IO; Legradi J; Legler J
[Ad] Endereço:Institute for Environmental Studies (IVM), VU University Amsterdam, 1081, HV, The Netherlands. Electronic address: renate.kopp@gmail.com.
[Ti] Título:Exposure to endocrine disrupting chemicals perturbs lipid metabolism and circadian rhythms.
[So] Source:J Environ Sci (China);62:133-137, 2017 Dec.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A growing body of evidence indicates that exposure to environmental chemicals can contribute to the etiology of obesity by inappropriately stimulating adipogenesis as well as perturbing lipid metabolism and energy balance. One potential mechanism by which chemical exposure can influence lipid metabolism is through disturbance of circadian rhythms, endogenously-driven cycles of roughly 24hr in length that coordinate biochemical, physiological, and behavioral processes in all organisms. Here we show for the first time that exposure to endocrine disrupting compounds (EDCs), including the pesticide tributyltin, two commercial flame retardants, and a UV-filter chemical found in sunscreens, can perturb both circadian clocks and lipid metabolism in vertebrates. Exposure of developing zebrafish to EDCs affects core clock activity and leads to a remarkable increase in lipid accumulation that is reminiscent of the effects observed for longdaysin, a known disruptor of circadian rhythms. Our data reveal a novel obesogenic mechanism of action for environmental chemicals, an observation which warrants further research. Because circadian clocks regulate a wide variety of physiological processes, identification of environmental chemicals capable of perturbing these systems may provide important insights into the development of environmentally-induced metabolic disease.
[Mh] Termos MeSH primário: Ritmo Circadiano/efeitos dos fármacos
Disruptores Endócrinos/toxicidade
Metabolismo dos Lipídeos/efeitos dos fármacos
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Retardadores de Chama
Praguicidas/toxicidade
Compostos de Trialquitina/toxicidade
Peixe-Zebra/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Endocrine Disruptors); 0 (Flame Retardants); 0 (Pesticides); 0 (Trialkyltin Compounds); 0 (Water Pollutants, Chemical); 4XDX163P3D (tributyltin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180103
[Lr] Data última revisão:
180103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180101
[St] Status:MEDLINE


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[PMID]:28977589
[Au] Autor:Shoucri BM; Martinez ES; Abreo TJ; Hung VT; Moosova Z; Shioda T; Blumberg B
[Ad] Endereço:Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California 92697-2300.
[Ti] Título:Retinoid X Receptor Activation Alters the Chromatin Landscape To Commit Mesenchymal Stem Cells to the Adipose Lineage.
[So] Source:Endocrinology;158(10):3109-3125, 2017 Oct 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Developmental exposure to environmental factors has been linked to obesity risk later in life. Nuclear receptors are molecular sensors that play critical roles during development and, as such, are prime candidates to explain the developmental programming of disease risk by environmental chemicals. We have previously characterized the obesogen tributyltin (TBT), which activates the nuclear receptors peroxisome proliferator-activated receptor γ (PPARγ) and retinoid X receptor (RXR) to increase adiposity in mice exposed in utero. Mesenchymal stem cells (MSCs) from these mice are biased toward the adipose lineage at the expense of the osteoblast lineage, and MSCs exposed to TBT in vitro are shunted toward the adipose fate in a PPARγ-dependent fashion. To address where in the adipogenic cascade TBT acts, we developed an in vitro commitment assay that permitted us to distinguish early commitment to the adipose lineage from subsequent differentiation. TBT and RXR activators (rexinoids) had potent effects in committing MSCs to the adipose lineage, whereas the strong PPARγ activator rosiglitazone was inactive. We show that activation of RXR is sufficient for adipogenic commitment and that rexinoids act through RXR to alter the transcriptome in a manner favoring adipogenic commitment. RXR activation alters expression of enhancer of zeste homolog 2 (EZH2) and modifies genome-wide histone 3 lysine 27 trimethylation (H3K27me3) in promoting adipose commitment and programming subsequent differentiation. These data offer insights into the roles of RXR and EZH2 in MSC lineage specification and shed light on how endocrine-disrupting chemicals such as TBT can reprogram stem cell fate.
[Mh] Termos MeSH primário: Adipócitos/citologia
Adipogenia/efeitos dos fármacos
Adipogenia/genética
Cromatina/efeitos dos fármacos
Células Mesenquimais Estromais/citologia
Receptores X Retinoide/fisiologia
[Mh] Termos MeSH secundário: Adipogenia/fisiologia
Animais
Diferenciação Celular/efeitos dos fármacos
Diferenciação Celular/genética
Cromatina/fisiologia
Disruptores Endócrinos/farmacologia
Proteína Potenciadora do Homólogo 2 de Zeste/genética
Epigênese Genética/efeitos dos fármacos
Expressão Gênica/efeitos dos fármacos
Técnicas de Silenciamento de Genes/veterinária
Camundongos
Camundongos Endogâmicos C57BL
Obesidade/etiologia
PPAR gama/fisiologia
Receptores X Retinoide/efeitos dos fármacos
Análise de Sequência de RNA/veterinária
Compostos de Trialquitina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chromatin); 0 (Endocrine Disruptors); 0 (PPAR gamma); 0 (Retinoid X Receptors); 0 (Trialkyltin Compounds); 4XDX163P3D (tributyltin); EC 2.1.1.43 (Enhancer of Zeste Homolog 2 Protein); EC 2.1.1.43 (Ezh2 protein, mouse)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00348


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[PMID]:28709983
[Au] Autor:Hunakova L; Brtko J
[Ad] Endereço:Cancer Research Institute, BMC, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovak Republic. Electronic address: exonhun@savba.sk.
[Ti] Título:Sn- and Ge- triorganometallics exert different cytotoxicity and modulation of migration in triple-negative breast cancer cell line MDA-MB-231.
[So] Source:Toxicol Lett;279:16-21, 2017 Sep 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Among a variety of metal containing organic compounds, tin derivatives are enjoying an increasing interest and appear to be very promising as potential drug candidates. We studied eight organometallic derivatives, nuclear retinoid X receptor (RXR) ligands and two germanium containing derivates that do not serve as RXR ligands. Tributylgermanium chloride (TBGe) and triphenylgermanium chloride (TPGe) did not inhibit growth of human triple negative MDA-MB-231 breast cancer cells. On the other hand, the tributyltin derivatives were highly, the triphenyltin derivatives less cytotoxic, both groups with IC values of nanomolar range. All trialkyltin derivatives (tributyltin chloride, tributyltin bromide, tributyltin iodide, tributyltin hydride) and three triaryltin derivatives (triphenyltin chloride, triphenyltin hydride and triphenyltin hydroxide) caused caspase-3/7 dependent apoptosis. Those derivatives that showed no or weak cytotoxicity, TBGe, TPGe, and triphenyltin acetate, we found to reduce migration of tested triple negative breast cancer cells.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Movimento Celular/efeitos dos fármacos
Compostos Organometálicos/farmacologia
Compostos Orgânicos de Estanho/farmacologia
Neoplasias de Mama Triplo Negativas/tratamento farmacológico
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Caspase 3/metabolismo
Caspase 7/metabolismo
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Feminino
Seres Humanos
Concentração Inibidora 50
Invasividade Neoplásica
Receptores X Retinoide/efeitos dos fármacos
Receptores X Retinoide/metabolismo
Transdução de Sinais/efeitos dos fármacos
Fatores de Tempo
Compostos de Trialquitina/farmacologia
Neoplasias de Mama Triplo Negativas/metabolismo
Neoplasias de Mama Triplo Negativas/patologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Organometallic Compounds); 0 (Organotin Compounds); 0 (Retinoid X Receptors); 0 (Trialkyltin Compounds); 10038-98-9 (germanium chloride); 4XDX163P3D (tributyltin); 95T92AGN0V (triphenyltin); EC 3.4.22.- (CASP3 protein, human); EC 3.4.22.- (CASP7 protein, human); EC 3.4.22.- (Caspase 3); EC 3.4.22.- (Caspase 7)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170716
[St] Status:MEDLINE


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[PMID]:28707438
[Au] Autor:Mitra S; Srivastava A; Khandelwal S
[Ad] Endereço:Immunotoxicology Division, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow, India.
[Ti] Título:Long term impact of the endocrine disruptor tributyltin on male fertility following a single acute exposure.
[So] Source:Environ Toxicol;32(10):2295-2304, 2017 Oct.
[Is] ISSN:1522-7278
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Declining rate of human fertility is a growing concern, where lifestyle and environmental factors play an important role. We recently demonstrated that tributyltin (TBT), an omnipresent endocrine disruptor, affects testicular cells in vitro. In this study, male Wistar rats were gavaged a single dose of 10, 20, and 30 mg/kg TBT-chloride (TBTC) (to mimic accidental exposure in vivo) and sacrificed on day 3 and day 7, respectively. TBT bioavailability was evaluated by estimating total tin content, and essential metal levels were analyzed along with redox molecules (ROS and GSH/GSSG) to understand the effect on physiological conditions. Blood-testicular barrier (BTB) disruption, levels of associated proteins and activity of proteolytic enzymes were evaluated to understand the effect on BTB. Histological analysis of tissue architecture and effect on protein expression of steroidogenic, stress and apoptotic markers were also evaluated. Widespread TBTC pollution can be an eventual threat to male fertility worldwide.
[Mh] Termos MeSH primário: Disruptores Endócrinos/toxicidade
Fertilidade/efeitos dos fármacos
Compostos de Trialquitina/toxicidade
[Mh] Termos MeSH secundário: Animais
Apoptose
Peso Corporal/efeitos dos fármacos
Metabolismo dos Lipídeos/efeitos dos fármacos
Masculino
Tamanho do Órgão/efeitos dos fármacos
Oxirredução
Estresse Oxidativo/efeitos dos fármacos
Ratos Wistar
Espécies Reativas de Oxigênio/metabolismo
Testículo/efeitos dos fármacos
Testículo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Endocrine Disruptors); 0 (Reactive Oxygen Species); 0 (Trialkyltin Compounds); 4XDX163P3D (tributyltin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1002/tox.22446


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[PMID]:28528411
[Au] Autor:Kim NS; Hong SH; Shin KH; Shim WJ
[Ad] Endereço:Oil and POPs Research Group, Korea Institute of Ocean Science and Technology, Geoje, 53201, Republic of Korea.
[Ti] Título:Imposex in Reishia clavigera as an Indicator to Assess Recovery of TBT Pollution After a Total Ban in South Korea.
[So] Source:Arch Environ Contam Toxicol;73(2):301-309, 2017 Aug.
[Is] ISSN:1432-0703
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The temporal changes in the frequency and degree of imposex and tributyltin (TBT) levels in gastropod (Reishia clavigera) were evaluated in Jinhae Bay, 5 and 10 years after the total ban on TBT usage in South Korea. The frequency and degree of imposex decreased significantly after the ban, accompanied by an increase in the female-to-male ratio. The TBT concentrations in R. clavigera also decreased significantly after the ban. There were good correlations between the TBT concentration in rock shell and both the degree of imposex and the female-to-male ratio. The total TBT ban effectively reduced the TBT levels and the frequency and degree of imposex in R. clavigera. However, the current low exposure level in the study area is still sufficient to cause imposex in R. clavigera. More time is needed to reduce the TBT levels to levels that do not have adverse biological effects on R. clavigera.
[Mh] Termos MeSH primário: Política Ambiental
Gastrópodes/fisiologia
Compostos de Trialquitina/toxicidade
Poluentes Químicos da Água/toxicidade
Poluição Química da Água/legislação & jurisprudência
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
República da Coreia
Razão de Masculinidade
Compostos de Trialquitina/análise
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Trialkyltin Compounds); 0 (Water Pollutants, Chemical); 4XDX163P3D (tributyltin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170522
[St] Status:MEDLINE
[do] DOI:10.1007/s00244-017-0369-x


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[PMID]:28528410
[Au] Autor:Ohji M; Harino H
[Ad] Endereço:Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, 183-8509, Japan. ohji@cc.tuat.ac.jp.
[Ti] Título:Comparison of Toxicities of Metal Pyrithiones Including Their Degradation Compounds and Organotin Antifouling Biocides to the Japanese Killifish Oryzias latipes.
[So] Source:Arch Environ Contam Toxicol;73(2):285-293, 2017 Aug.
[Is] ISSN:1432-0703
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Japanese killifish Oryzias latipes were exposed to three levels (0, 1, and 10 µg l ) of copper pyrithione (CuPT ), zinc pyrithione (ZnPT ), six of their degradation products, and the organotin compounds tributyltin (TBT) and triphenyltin (TPT) for 48 h at 20 °C. All individual fish exposed to 1 and 10 µg l of CuPT or 10 µg l of ZnPT were dead within 12 h, respectively, and at 24 h the survival rate of the fish exposed to 1 µg l of ZnPT was 50%. All fish exposed to 10 µg l of ZnPT showed morphological abnormalities in the form of vertebral deformity. None of the fish exposed to six of the degradation products of PTs, TBT, and TPT died during a 48-h exposure period, but various biological effects were observed in the fish exposed to these chemicals: abnormalities of respiration and swimming behavior, and decreased hatchability. Our findings suggest that O. latipes has a higher ecological risk of CuPT and ZnPT exposure than of TBT and TPT exposure during their life history. Because these antifouling biocides have been used in both freshwater and marine environments, our results highlight these biocides' deleterious effects on the freshwater fish as well as marine fish, and they indicate freshwater and marine pollution.
[Mh] Termos MeSH primário: Desinfetantes/toxicidade
Metais/toxicidade
Piridinas/toxicidade
Tionas/toxicidade
Testes de Toxicidade
[Mh] Termos MeSH secundário: Animais
Compostos Organometálicos/toxicidade
Compostos Orgânicos de Estanho/toxicidade
Oryzias
Compostos de Trialquitina/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Disinfectants); 0 (Metals); 0 (Organometallic Compounds); 0 (Organotin Compounds); 0 (Pyridines); 0 (Thiones); 0 (Trialkyltin Compounds); 0 (copper pyrithione); 4XDX163P3D (tributyltin); 6GK82EC25D (pyrithione); 95T92AGN0V (triphenyltin); R953O2RHZ5 (pyrithione zinc)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170522
[St] Status:MEDLINE
[do] DOI:10.1007/s00244-017-0367-z


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[PMID]:28527383
[Au] Autor:Lutfi E; Riera-Heredia N; Córdoba M; Porte C; Gutiérrez J; Capilla E; Navarro I
[Ad] Endereço:Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Barcelona 08028, Spain.
[Ti] Título:Tributyltin and triphenyltin exposure promotes in vitro adipogenic differentiation but alters the adipocyte phenotype in rainbow trout.
[So] Source:Aquat Toxicol;188:148-158, 2017 Jul.
[Is] ISSN:1879-1514
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Numerous environmental pollutants have been identified as potential obesogenic compounds affecting endocrine signaling and lipid homeostasis. Among them, well-known organotins such as tributyltin (TBT) and triphenyltin (TPT), can be found in significant concentrations in aquatic environments. The aim of the present study was to investigate in vitro the effects of TBT and TPT on the development and lipid metabolism of rainbow trout (Onchorynchus mykiss) primary cultured adipocytes. Results showed that TBT and TPT induced lipid accumulation and slightly enhanced peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT enhancer binding protein alpha (C/EBPα) protein expression when compared to a control, both in the presence or absence of lipid mixture. However, the effects were higher when combined with lipid, and in the absence of it, the organotins did not cause complete mature adipocyte morphology. Regarding gene expression analyses, exposure to TBT and TPT caused an increase in fatty acid synthase (fasn) mRNA levels confirming the pro-adipogenic properties of these compounds. In addition, when added together with lipid, TBT and TPT significantly increased cebpa, tumor necrosis factor alpha (tnfa) and ATP-binding cassette transporter 1 (abca1) mRNA levels suggesting a synergistic effect. Overall, our data highlighted that TBT and TPT activate adipocyte differentiation in rainbow trout supporting an obesogenic role for these compounds, although by themselves they are not able to induce complete adipocyte development and maturation suggesting that these adipocytes might not be properly functional.
[Mh] Termos MeSH primário: Adipócitos/efeitos dos fármacos
Adipogenia/efeitos dos fármacos
Compostos Orgânicos de Estanho/toxicidade
Compostos de Trialquitina/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Transportadores de Cassetes de Ligação de ATP/genética
Animais
Proteína alfa Estimuladora de Ligação a CCAAT/metabolismo
Metabolismo dos Lipídeos/efeitos dos fármacos
Oncorhynchus mykiss/metabolismo
PPAR gama/metabolismo
Fenótipo
Fator de Necrose Tumoral alfa/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CCAAT-Enhancer-Binding Protein-alpha); 0 (Organotin Compounds); 0 (PPAR gamma); 0 (Trialkyltin Compounds); 0 (Tumor Necrosis Factor-alpha); 0 (Water Pollutants, Chemical); 4XDX163P3D (tributyltin); 95T92AGN0V (triphenyltin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170521
[St] Status:MEDLINE



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