Base de dados : MEDLINE
Pesquisa : D02.705.400 [Categoria DeCS]
Referências encontradas : 4258 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 426 ir para página                         

  1 / 4258 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29175403
[Au] Autor:Liang Y; Liu X; Allen MR
[Ad] Endereço:Oak Ridge Institute for Science and Education Participant at U.S. Environmental Protection Agency, USA.
[Ti] Título:Measuring and modeling surface sorption dynamics of organophosphate flame retardants on impervious surfaces.
[So] Source:Chemosphere;193:754-762, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Understanding the sorption mechanisms for organophosphate flame retardants (OPFRs) on impervious surfaces is important to improve our knowledge of the fate and transport of OPFRs in indoor environments. The sorption processes of semivolatile organic compounds (SVOCs) on indoor surfaces are heterogeneous (multilayer sorption) or homogeneous (monolayer sorption). In this study, we adopted simplified Langmuir isotherm and Freundlich isotherm in a dynamic sink model to characterize the sorption dynamics of OPFRs on impervious surfaces such as stainless steel and made comparisons between the two models through a series of empty chamber studies. The tests involve two types of stainless steel chambers (53-L small chambers and 44-mL micro chambers) using tris(2-chloroethyl)phosphate (TCEP) and tris(1-chloro-2-propyl)phosphate (TCPP) as target compounds. Our test results show that the dynamic sink model using Freundlich isotherm can better represent the sorption process in the empty small chamber. Micro chamber test results from this study show that the sink model using both simplified Langmuir isotherm and Freundlich isotherm can well fit the measured gas-phase concentrations of OPFRs. We further applied both models and the parameters obtained to predict the gas phase concentrations of OPFRs in a small chamber with an emission source. Comparisons between model predictions and measurements demonstrate the reliability and applicability of the sorption parameters.
[Mh] Termos MeSH primário: Adsorção
Retardadores de Chama/farmacologia
Modelos Teóricos
Organofosfatos/química
[Mh] Termos MeSH secundário: Organofosfatos/farmacologia
Compostos Organofosforados
Reprodutibilidade dos Testes
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flame Retardants); 0 (Organophosphates); 0 (Organophosphorus Compounds); 0 (tris(1-chloro-2-propyl)phosphate); 32IVO568B0 (tris(chloroethyl)phosphate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  2 / 4258 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29175399
[Au] Autor:Stubbings WA; Harrad S
[Ad] Endereço:School of Geography, Earth, & Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, UK. Electronic address: william.a.stubbings@gmail.com.
[Ti] Título:Leaching of TCIPP from furniture foam is rapid and substantial.
[So] Source:Chemosphere;193:720-725, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A series of laboratory experiments were conducted, in which waste furniture polyurethane foam samples containing tris (1-chloro-2-propyl) phosphate (TCIPP) were contacted with a range of leaching fluids, formulated to simulate the composition of landfill leachate. Leaching was examined under a number of different scenarios, such as: dissolved humic matter concentration, pH, and temperature, as well as the effect of agitation, and waste:leaching fluid contact duration. In addition to single batch (no replenishment of leaching fluid), serial batch (draining of leachate and replenishment with fresh leaching fluid at various time intervals) experiments were conducted. Leaching of TCIPP from PUF appears to be a first order process. Concentrations of TCIPP in leachate generated by the experiments in this study ranged from 13 mg L to 130 mg L . In serial batch leaching experiments, >95% of TCIPP was depleted from PUF after 168 h total contact with leaching fluid. Our experiments indicate leaching is potentially a very significant pathway of TCIPP emissions to the environment.
[Mh] Termos MeSH primário: Poluição Ambiental
Retardadores de Chama/toxicidade
Decoração de Interiores e Mobiliário
Organofosfatos/química
Poliuretanos/toxicidade
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Cinética
Solubilidade
Soluções/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flame Retardants); 0 (Organophosphates); 0 (Polyurethanes); 0 (Solutions); 0 (Water Pollutants, Chemical); 9009-54-5 (polyurethane foam)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  3 / 4258 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28985534
[Au] Autor:Yadav IC; Devi NL; Li J; Zhang G
[Ad] Endereço:State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, PR China; Department of International Environmental and Agricultural Science (IEAS), Tokyo University of Agriculture and Technology (TUAT), 3-5-8, Saiwai-Cho, Fuchu-Shi,
[Ti] Título:Organophosphate ester flame retardants in Nepalese soil: Spatial distribution, source apportionment and air-soil exchange assessment.
[So] Source:Chemosphere;190:114-123, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Despite soil being the major terrestrial environmental reservoir and one of the significant sinks for many hydrophobic organic compounds including organophosphate ester flame retardants (OPFRs), limited information is available about concentration and fate of OPFRs contamination in urban soil in general and especially in case of Nepal. This study investigates the environmental concentration, spatial distribution and source apportionment of eight OPFRs in surface soil (n = 28) from four major cities of Nepal with special interest on air-soil exchange. Overall, significantly high concentrations of ∑ OPFR were measured in soil ranging from 25-27,900 ng/g dw (median 248 ng/g dw). In terms of compositional pattern, tris(methyl phenyl) phosphate (TMPP) was the most abundant phosphorus chemical in soil, followed by tris(2-chloroisopropyl) phosphate (TCIPP), and accounted for 35-49% and 8-25% of ∑ OPFRs, respectively. The high level of these OPFRs was attributed to local sources as opposed to transboundary influence from remote areas. A Spearman's rank correlation analysis exhibited weak correlation of ∑ OPFRs with TOC (Rho = 0.117, p < 0.05) and BC (Rho = 0.007, p < 0.05), suggesting little or no influence of TOC and BC on the concentration of ∑ OPFRs. The fugacity fraction (ff) results indicated a strong influence of soil contamination on atmospheric level of OPFRs via volatilization.
[Mh] Termos MeSH primário: Retardadores de Chama/análise
Organofosfatos/análise
Poluentes do Solo/análise
[Mh] Termos MeSH secundário: Poluentes Atmosféricos/análise
Poluentes Atmosféricos/química
Poluição do Ar/análise
Cidades
Nepal
Solo/química
Poluentes do Solo/química
Volatilização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Flame Retardants); 0 (Organophosphates); 0 (Soil); 0 (Soil Pollutants)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


  4 / 4258 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29384903
[Au] Autor:De Anda C; Anuskiewicz S; Prokocimer P; Vazquez J
[Ad] Endereço:Merck & Co., Inc., Kenilworth, NJ, USA.
[Ti] Título:Outpatient treatment of acute bacterial skin and skin structure infections (ABSSSI) with tedizolid phosphate and linezolid in patients in the United States: Subgroup analysis of 2 randomized phase 3 trials.
[So] Source:Medicine (Baltimore);96(52):e9163, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Acute bacterial skin and skin structure infections (ABSSSI) are a frequent cause of hospital admissions in the United States. Safe and effective outpatient treatments may lower ABSSSI-associated health care costs by reducing unnecessary hospital admissions. Using data from 2 phase 3 trials (ESTABLISH-1, NCT01170221; ESTABLISH-2, NCT01421511), this post-hoc analysis explored the efficacy and safety of tedizolid in an outpatient setting. METHODS: Subgroup analysis was performed on US outpatients (defined as patients who were not in hospital at the time of treatment initiation) with ABSSSI caused by presumed or proven gram-positive pathogens. Patients were randomly assigned to receive tedizolid phosphate 200 mg once daily for 6 days (n = 403) or linezolid 600 mg twice daily for 10 days (n = 410). The primary end point was early clinical response (48-72 hours after the start of treatment). Secondary end points included investigator-assessed clinical response at end of therapy (EOT) and post-therapy evaluation (PTE; 7-14 days after therapy). Additional assessments included the patient-reported level of pain using a visual analog scale (VAS) and the per-pathogen favorable microbiological response rate at the PTE visit. Compliance with treatment and safety outcomes was also recorded. RESULTS: Early clinical response was similar between treatment groups (tedizolid, 82.4%; linezolid, 79.0%), as was investigator-assessed clinical response at EOT (tedizolid, 87.1%; linezolid, 86.1%) and PTE (tedizolid, 83.1%; linezolid, 83.7%). Mean changes from baseline to days 10 to 13 in VAS scores were identical between treatment groups (tedizolid, -51.9 mm; linezolid, -51.9 mm). Microbiological eradication rates were generally similar in both treatment groups for all key pathogens. Patients in both groups had favorable response at PTE. More tedizolid-treated patients (89.3%) than linezolid-treated patients (77.3%) were compliant with treatment. The most frequently reported drug-related treatment-emergent adverse events were nausea (tedizolid, 10.7%; linezolid, 13.8%), diarrhea (tedizolid, 4.5%; linezolid, 5.9%), and headache (tedizolid, 5.5%; linezolid, 4.4%). Treatment discontinuation rates were low for both treatment groups (tedizolid, 0.7%; linezolid, 1.0%). CONCLUSION: Short-course therapy with tedizolid can successfully treat patients with ABSSSI caused by presumed or proven gram-positive pathogens in an outpatient setting.
[Mh] Termos MeSH primário: Assistência Ambulatorial
Antibacterianos/uso terapêutico
Linezolida/uso terapêutico
Organofosfatos/uso terapêutico
Oxazóis/uso terapêutico
Dermatopatias Bacterianas/tratamento farmacológico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Dermatopatias Bacterianas/patologia
Resultado do Tratamento
Estados Unidos
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE III; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Organophosphates); 0 (Oxazoles); ISQ9I6J12J (Linezolid); O7DRJ6R4DW (torezolid phosphate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009163


  5 / 4258 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29442005
[Au] Autor:Petroianu GA
[Ti] Título:Neuropathic organophosphates: from Scrugham, Heim and Lorot to Jake leg paralysis.
[So] Source:Pharmazie;71(12):738-744, 2016 Dec 01.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Henry Scrugham (1811-1898), the father of triphenyl-phosphate, was a student of Alexander Williamson (1824-1904), Professor of analytical and practical chemistry at the University College London. Williamson using the approach perfected by Scurgham reacted phosphorus pentachloride with cresol (a mixture of ortho, para and meta isomers) thus obtaining tricresyl phosphate (TCP). The triesters of phenol, cresol and naphtol were prepared with a higher yield by Rudolf Heim (1861-1919) by their respective reaction with phosphorus oxychloride (POCl3). Heim is also the first one to obtain pure tri-o-cresyl phosphate (TOCP). In the meantime French pharmacist Jules Brissonnet (1859-1915) synthesized creosote phosphate (containing i.a. TOCP) and popularized its use in the treatment of pulmonary phthisis (tuberculosis). Camille Lorot (1872-1951) and others in France and Germany recognized the ability of creosote phosphate to induce polyneuropathies but this knowledge did not prevent the Ginger Jake epidemic (Jake leg) of the 1930s in the US. The Jake induced neuropathy was first recognized and described in Oklahoma City by a General Practitioner, Ephraim Goldfain (1894-1983). Soon thereafter Maurice Isadore Smith (1887-1951), a pharmacologist, and chemist Elias Elvove (1883-1962) identified TOCP in Jamaican ginger extract as the causative agent. We attempt to shed some light on the life and family of the less known chemists, pharmacists and physicians associated with the synthesis of neuropathic organophosphates and with the recognition of their toxicity.
[Mh] Termos MeSH primário: Síndromes Neurotóxicas/história
Organofosfatos/toxicidade
[Mh] Termos MeSH secundário: História do Século XIX
História do Século XX
Síndromes Neurotóxicas/patologia
Organofosfatos/síntese química
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Ps] Nome de pessoa como assunto:Scrugham H; Heim R; Brissonnet J; Goldfain E; Elvove E; Smith M
[Nm] Nome de substância:
0 (Organophosphates)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6080


  6 / 4258 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29306024
[Au] Autor:Hill KL; Hamers T; Kamstra JH; Willmore WG; Letcher RJ
[Ad] Endereço:Ecotoxicology and Wildlife Health Division, Environment and Climate Change Canada, National Wildlife Research Centre, Carleton University, Ottawa, Canada; Department of Biology, Carleton University, Ottawa, Canada; Intrinsik Corp., Ottawa, Canada.
[Ti] Título:Organophosphate triesters and selected metabolites enhance binding of thyroxine to human transthyretin in vitro.
[So] Source:Toxicol Lett;285:87-93, 2018 Mar 15.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The toxicological properties of organophosphate (OP) triesters that are used as flame retardants and plasticizers are currently not well understood, though increasing evidence suggests they can affect the thyroid system. Perturbation of thyroid hormone (TH) transport is one mechanism of action that may affect thyroid function. The present study applied an in vitro competitive protein binding assay with thyroxine (T4) and human transthyretin (hTTR) transport protein to determine the potential for the OP triesters, TDCIPP (tris(1,3-dichloro-2-propyl) phosphate), TBOEP (tris(butoxyethyl) phosphate), TEP (triethyl phosphate), TPHP (triphenyl phosphate), p-OH-TPHP (para-hydroxy triphenyl phosphate), and the OP diester DPHP (diphenyl phosphate), to competitively displace T4 from hTTR. Enhancement of T4 binding to hTTR, rather than the hypothesized competition, was observed for the six OP esters and in a concentration-dependent manner. For example, T4-hTTR binding was significantly increased at concentrations of TBOEP as low as 64 nM, and up to 184% of controls at 5000 nM. A plausible explanation of these results, which to our knowledge has not been previously reported, may be allosteric interactions of the OP esters with hTTR allowing T4 to access the second site of the TH binding pocket. These in vitro results suggest a novel mechanism of OP ester toxicity via T4 binding enhancement, and possible dysregulation of T4-hTTR interactions.
[Mh] Termos MeSH primário: Retardadores de Chama/toxicidade
Organofosfatos/toxicidade
Plastificantes/toxicidade
Pré-Albumina/metabolismo
Tiroxina/metabolismo
[Mh] Termos MeSH secundário: Ligação Competitiva
Ésteres
Retardadores de Chama/metabolismo
Seres Humanos
Organofosfatos/metabolismo
Plastificantes/metabolismo
Ligação Proteica
Glândula Tireoide/efeitos dos fármacos
Glândula Tireoide/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Esters); 0 (Flame Retardants); 0 (Organophosphates); 0 (Plasticizers); 0 (Prealbumin); Q51BO43MG4 (Thyroxine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180107
[St] Status:MEDLINE


  7 / 4258 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28992474
[Au] Autor:Liu J; Ye J; Chen Y; Li C; Ou H
[Ad] Endereço:School of Environment, Guangzhou Key Laboratory of Environmental Exposure and Health, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, China.
[Ti] Título:UV-driven hydroxyl radical oxidation of tris(2-chloroethyl) phosphate: Intermediate products and residual toxicity.
[So] Source:Chemosphere;190:225-233, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Organophosphorus esters (OPEs) are emerging contaminants widely applied as annexing agents in a variety of industrial products, and they are robust against conventional wastewater treatments. Ultraviolet-driven (UV) radical-based advanced oxidation processes have a potential to become cost-effective treatment technologies for the removal of OPEs in water matrix, but residual and newly generated toxicities of degradation products are a concern. This study is a comprehensive attempt to evaluate UV/H O for the degradation of a water dissolved OPE, tris(2-chloroethyl) phosphate (TCEP). In ultrapure water, a pseudo-first order reaction was observed, and the degradation rate constant reached 0.155 min for 3.5 µM TCEP using 7.0 mW cm UV irradiation with 44.0 µM H O . Hydroxyl radicals were involved in the oxidative degradation of TCEP, as demonstrated by the quenching of the degradation reaction in the presences of tertiary butanol or ethanol. High resolution mass spectroscopy data showed a partial transformation of TCEP to a series of hydroxylated and dechlorinated products e.g., C H Cl O P, C H Cl O P and C H ClO P. Based on proteomics data at molecular and metabolic network levels, the toxicity of TCEP products was reduced obviously as the reaction proceeded, which was confirmed by the up-regulated tricarboxylic acid cycle, fatty acid metabolism and amino acid metabolism in Escherichia coli cells exposed to degradation products mixture. In conclusion, incomplete hydroxylation and dechlorination of TCEP likewise are effective for its detoxification, indicating that UV/H O can be a promising treatment method for OPEs removal.
[Mh] Termos MeSH primário: Peróxido de Hidrogênio/química
Radical Hidroxila/química
Organofosfatos/química
Raios Ultravioleta
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Escherichia coli/metabolismo
Halogenação
Cinética
Organofosfatos/isolamento & purificação
Oxirredução
Águas Residuais/química
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organophosphates); 0 (Waste Water); 0 (Water Pollutants, Chemical); 3352-57-6 (Hydroxyl Radical); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171010
[St] Status:MEDLINE


  8 / 4258 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28743514
[Au] Autor:Herbert J; Thiermann H; Worek F; Wille T
[Ad] Endereço:Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany.
[Ti] Título:Precision cut lung slices as test system for candidate therapeutics in organophosphate poisoning.
[So] Source:Toxicology;389:94-100, 2017 08 15.
[Is] ISSN:1879-3185
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Standard therapeutic options in organophosphate (OP) poisoning are limited to the administration of atropine and oximes, a regimen often lacking in efficacy and applicability. Treatment alternatives are needed, preferably covering a broad spectrum of OP intoxications. Although recent research yielded several promising compounds, e.g. bioscavengers, modulators of the muscarinic acetylcholine (ACh) receptor or bispyridinium non-oximes, these substances still need further evaluation, especially regarding effects on the potentially lethal respiratory symptoms of OP poisoning. Aim of this study was the development of an applicable and easy method to test the therapeutic efficiency of such substances. For this purpose, airway responsiveness in viable precision cut lung slices (PCLS) from rats was analysed. We showed that ACh-induced airway contractions were spontaneously reversible in non-poisoned PCLS, whereas in OP poisoned PCLS, contractions were irreversible. This effect could be antagonized by addition of the standard therapeutic atropine, thereby presenting a clear indication for treatment efficiency. Now, candidate therapeutic compounds can be evaluated, based on their ability to counteract the irreversible airway contraction in OP poisoned PCLS.
[Mh] Termos MeSH primário: Antídotos/farmacologia
Atropina/farmacologia
Broncoconstrição/efeitos dos fármacos
Broncodilatadores/farmacologia
Descoberta de Drogas/métodos
Pulmão/efeitos dos fármacos
Antagonistas Muscarínicos/farmacologia
Contração Muscular/efeitos dos fármacos
Músculo Liso/efeitos dos fármacos
Agentes Neurotóxicos/toxicidade
Intoxicação por Organofosfatos/tratamento farmacológico
Organofosfatos/toxicidade
[Mh] Termos MeSH secundário: Acetilcolina/farmacologia
Animais
Relação Dose-Resposta a Droga
Pulmão/fisiopatologia
Masculino
Músculo Liso/fisiopatologia
Intoxicação por Organofosfatos/fisiopatologia
Ratos Wistar
Fatores de Tempo
Técnicas de Cultura de Tecidos
Sobrevivência de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antidotes); 0 (Bronchodilator Agents); 0 (Muscarinic Antagonists); 0 (Nerve Agents); 0 (Organophosphates); 7C0697DR9I (Atropine); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


  9 / 4258 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28941720
[Au] Autor:Liang K; Shi F; Liu J
[Ad] Endereço:State Key Laboratory of Environmental and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
[Ti] Título:Occurrence and distribution of oligomeric organophosphorus flame retardants in different treatment stages of a sewage treatment plant.
[So] Source:Environ Pollut;232:229-235, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Oligomeric organophosphate esters (OOPEs) like 2,2-bis(chloromethyl)-propane-1,3-diyltetrakis (2-chloroethyl) bisphosphate (V6), resorcinol bis(diphenylphosphate) (RDP) and bisphenol A bis(diphenylphosphate) (BDP), are widely used as alternatives of Deca-BDE in plastic and electronic consumer products. However, studies on the environmental occurrence and fate of OOPEs are very scarce. This work studied the occurrence, distribution and fate of V6, BDP and RDP during the different treatment stages of a sewage treatment plant (STP) in Beijing, China. To accomplish this, a method to analyze trace V6, BDP and RDP in suspended solids samples and aqueous samples of sewage and sludge was developed by using liquid chromatography tandem mass spectrometry (LC-MS/MS). Using this method, BDP and RDP were detected for the first time in suspended solids of sewage and sludge with a concentration of 2.06-5.82 ng/g dry weight and 0.44-3.45 ng/g dry weight, respectively, whereas their concentration level in the aqueous phase of these samples were below the detection limits of the method. However, V6 was detected in all treatment stages of the STP, with concentrations in the range of 10.2-27.1 ng/L in aqueous phase and 0.40-1.73 ng/g dw in solid phase. Mass balance results indicated that 75.6% of the original V6 mass flow was discharged along with effluent, while 83.3% and 72.2% of the initial RDP and BDP mass flow were lost due to biodegradation, respectively. Nevertheless, compared to the 14 widely used monomeric organophosphate esters (MOPEs), the concentration levels of OOPEs in this studied STP were relatively low.
[Mh] Termos MeSH primário: Monitoramento Ambiental
Retardadores de Chama/análise
Eliminação de Resíduos Líquidos
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Pequim
Compostos Benzidrílicos/análise
Biodegradação Ambiental
China
Cromatografia Líquida
Organofosfatos/análise
Fenóis/análise
Plásticos/análise
Resorcinóis
Esgotos/química
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Flame Retardants); 0 (Organophosphates); 0 (Phenols); 0 (Plastics); 0 (Resorcinols); 0 (Sewage); 0 (Water Pollutants, Chemical); MLT3645I99 (bisphenol A); YUL4LO94HK (resorcinol)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170925
[St] Status:MEDLINE


  10 / 4258 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28456308
[Au] Autor:Mou X; Yuan GR; Jiang HB; Liu Z; Wang JJ
[Ad] Endereço:Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing 400716, People's Republic of China.
[Ti] Título:Functional characterization of two acetylcholinesterase genes in the brown citrus aphid, Aphis (Toxoptera) citricidus (Kirkaldy), using heterologous expression and RNA interference.
[So] Source:Pestic Biochem Physiol;138:76-83, 2017 May.
[Is] ISSN:1095-9939
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Acetylcholinesterase (AChE) is the primary target of organophosphate- and carbamate-based insecticides. We sequenced the full-length cDNAs of two AChE genes from the brown citrus aphid Aphis (Toxoptera) citricidus (Kirkaldy). These two genes, Tcace1 and Tcace2, which encode TcAChE1 and TcAChE2, respectively, had a shared amino acid identity of 29% and were highly similar to other insect ace1 and ace2 genes, respectively, having specific functional motifs. Potential differences in enzymatic function were characterized by the heterologous expression of the two genes using a baculovirus system in Sf9 insect cells. Both of the recombinant AChEs had high specific activities for three typical substrates, acetylthiocholine iodide, butyrylthiocholine iodide, and propinylthiocholine iodide. TcAChE1 had a lower Michaelis-Menten constant value and a higher maximal reaction velocity than recombinant TcAChE2, indicating a higher affinity for substrates and greater catalytic efficiency, respectively. Bioassays showed a greater sensitivity of recombinant TcAChE1 to the 10 tested insecticides. Silencing of Tcace1 and Tcace2 by RNA interference significantly increased the susceptibility of A. citricidus to malathion and carbaryl; however, silencing Tcace1 resulted in a higher mortality rate than silencing Tcace2. Additionally, the specific enzyme activity decreased more after silencing Tcace1 than after silencing Tcace2. Thus, TcAChE1 plays a major role in postsynaptic neurotransmission in A. citricidus.
[Mh] Termos MeSH primário: Acetilcolinesterase/metabolismo
Afídeos/enzimologia
Regulação Enzimológica da Expressão Gênica/fisiologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/genética
Sequência de Aminoácidos
Animais
Afídeos/genética
Afídeos/metabolismo
Carbamatos/farmacologia
Clonagem Molecular
DNA Complementar
Resistência a Inseticidas/genética
Inseticidas/farmacologia
Organofosfatos/farmacologia
Filogenia
Interferência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbamates); 0 (DNA, Complementary); 0 (Insecticides); 0 (Organophosphates); EC 3.1.1.7 (Acetylcholinesterase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE



página 1 de 426 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde