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[PMID]:28577486
[Au] Autor:Kadar A; Peyre L; de Souza G; Wortham H; Doumenq P; Rahmani R
[Ad] Endereço:Aix Marseille Univ, CNRS, LCE, Marseille, France; INRA, UMR 1331 TOXALIM, Laboratoire de Toxicologie Cellulaire et Moléculaire des Xénobiotiques, BP 167, 400 Route des Chappes, 06903, Sophia Antipolis Cedex, France. Electronic address: ali.kadar@etu.univ-amu.fr.
[Ti] Título:An accurate and robust LC-MS/MS method for the quantification of chlorfenvinphos, ethion and linuron in liver samples.
[So] Source:Chemosphere;184:20-26, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A method for the determination of chlorfenvinphos, ethion and linuron in liver samples by LC-MS/MS is described. Sample treatment was performed by using Sola™ polymeric reverse phase SPE cartridges after protein precipitation. Gradient elution using 10 mM ammonium formate in methanol (A) and 10 mM ammonium formate in water (B) was used for chromatographic separation of analytes on a Hypersil™ end-capped Gold PFP reverse phase column (100 mm × 2.1 mm, 3 µm). All analytes were quantified without interference, in positive ionization mode using multiple reaction monitoring (MRM) with chlorfenvinphos-d10 as internal standard. The whole procedure was validated according to the FDA guidelines for bioanalytical methods. The calibration curves for chlorfenvinphos, linuron and ethion compounds were linear over the concentration range of 0.005-2 µM (i.e. 0.0018-0.720 µg/mL, 0.0019-0.770 µg/mL and 0.0012-0.500 µg/mL respectively) with coefficients of determination higher than 0.998. A Lower limit of quantification of 0.005 µM was achieved for all analytes, i.e. 5.76, 6.08 and 3.84 µg/kg of liver for chlorfenvinphos, ethion and linuron respectively. Compounds extraction recovery rates ranged from 92.9 to 99.5% with a RSD of 2.3%. Intra- and inter-day accuracies were within 90.9 and 100%, and imprecision varied from 0.8 to 8.2%. Stability tests proved all analytes were stable in liver extracts during instrumental analysis (+12 °C in autosampler tray for 72 h) at the end of three successive freeze-thaw cycles and at -20 °C for up to 9 months. This accurate and robust analytical method is therefore suitable for contamination or metabolism studies.
[Mh] Termos MeSH primário: Clorfenvinfos/análise
Linurona/análise
Fígado/química
Compostos Organotiofosforados/análise
Praguicidas/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida/métodos
Reprodutibilidade dos Testes
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organothiophosphorus Compounds); 0 (Pesticides); 01XP1SU59O (Linuron); 2TI07NO12Y (ethion); F2G9XS1W91 (Chlorfenvinphos)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170604
[St] Status:MEDLINE


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[PMID]:28476006
[Au] Autor:Kadar A; de Sousa G; Peyre L; Wortham H; Doumenq P; Rahmani R
[Ad] Endereço:Aix Marseille Univ, CNRS, LCE, Marseille, France; INRA, UMR 1331 TOXALIM, Laboratoire de Toxicologie Cellulaire et Moléculaire des Xénobiotiques, BP 167, 400 Route des Chappes, 06903, Sophia Antipolis Cedex, France. Electronic address: ali.kadar@etu.univ-amu.fr.
[Ti] Título:Evidence of in vitro metabolic interaction effects of a chlorfenvinphos, ethion and linuron mixture on human hepatic detoxification rates.
[So] Source:Chemosphere;181:666-674, 2017 Aug.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:General population exposure to pesticides mainly occurs via food and water consumption. However, their risk assessment for regulatory purposes does not currently consider the actual co-exposure to multiple substances. To address this concern, relevant experimental studies are needed to fill the lack of data concerning effects of mixture on human health. For the first time, the present work evaluated on human microsomes and liver cells the combined metabolic effects of, chlorfenvinphos, ethion and linuron, three pesticides usually found in vegetables of the European Union. Concentrations of these substances were measured during combined incubation experiments, thanks to a new analytical methodology previously developed. The collected data allowed for calculation and comparison of the intrinsic hepatic clearance of each pesticide from different combinations. Finally, the results showed clear inhibitory effects, depending on the association of the chemicals at stake. The major metabolic inhibitor observed was chlorfenvinphos. During co-incubation, it was able to decrease the intrinsic clearance of both linuron and ethion. These latter also showed a potential for metabolic inhibition mainly cytochrome P450-mediated in all cases. Here we demonstrated that human detoxification from a pesticide may be severely hampered in case of co-occurrence of other pesticides, as it is the case for drugs interactions, thus increasing the risk of adverse health effects. These results could contribute to improve the current challenging risk assessment of human and animal dietary to environmental chemical mixtures.
[Mh] Termos MeSH primário: Inativação Metabólica/efeitos dos fármacos
Fígado/efeitos dos fármacos
Praguicidas/metabolismo
[Mh] Termos MeSH secundário: Animais
Clorfenvinfos/metabolismo
Clorfenvinfos/farmacologia
Sistema Enzimático do Citocromo P-450/metabolismo
Hepatócitos/efeitos dos fármacos
Seres Humanos
Linurona/metabolismo
Linurona/farmacologia
Fígado/citologia
Fígado/fisiologia
Taxa de Depuração Metabólica/efeitos dos fármacos
Microssomos Hepáticos/efeitos dos fármacos
Compostos Organotiofosforados/metabolismo
Compostos Organotiofosforados/farmacologia
Praguicidas/química
Praguicidas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organothiophosphorus Compounds); 0 (Pesticides); 01XP1SU59O (Linuron); 2TI07NO12Y (ethion); 9035-51-2 (Cytochrome P-450 Enzyme System); F2G9XS1W91 (Chlorfenvinphos)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170506
[St] Status:MEDLINE


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[PMID]:28115176
[Au] Autor:Wellington KW; Leboho T; Sakong BM; Adenubi OT; Eloff JN; Fouche G
[Ad] Endereço:CSIR Biosciences, PO Box 395, Pretoria, South Africa. Electronic address: kwellington@csir.co.za.
[Ti] Título:Further studies on South African plants: Acaricidal activity of organic plant extracts against Rhipicephalus (Boophilus) microplus (Acari: Ixodidae).
[So] Source:Vet Parasitol;234:10-12, 2017 Jan 30.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The goal of our research is to develop a lower cost eco-friendly tick control method because acaricides that are commonly used to control ticks are often toxic, harmful to the environment or too expensive for resource-limited farmers. Acetone and ethanol extracts were prepared and their acaricidal activities determined against the southern cattle tick, Rhipicephalus (Boophilus) microplus. A 1% solution of each of the plant extracts was prepared for efficacy testing using the adapted Shaw Larval Immersion Test (SLIT). The acetone stem extract from Cissus quadrangularis (Vitaceae) and the ethanol leaf and flower extract from Calpurnia aurea (Fabaceae) had potent activity like that of the commercial acaricide, chlorfenvinphos [corrected mortality (CM)=100.0%]. The ethanol extracts of the stem of C. quadrangularis (CM=98.9%) and that of the roots, leaves and fruit of Senna italica subsp arachoides (CM=96.7%) also had good acaricidal activity. There is potential for the development of botanicals as natural acaricides against R. (B.) microplus that can be used commercially to protect animals against tick infestation. Further studies to isolate the acaricidal active compounds and to determine the environmental fate, species toxicity and skin toxicity of these plants species are, however, required before they can be considered as a treatment against ticks.
[Mh] Termos MeSH primário: Acaricidas
Cissus/química
Fabaceae/química
Extratos Vegetais/farmacologia
Rhipicephalus/efeitos dos fármacos
Controle de Ácaros e Carrapatos
[Mh] Termos MeSH secundário: Acetona/química
Animais
Clorfenvinfos/farmacologia
Etanol/química
Larva/efeitos dos fármacos
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Plant Extracts); 1364PS73AF (Acetone); 3K9958V90M (Ethanol); F2G9XS1W91 (Chlorfenvinphos)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170203
[Lr] Data última revisão:
170203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE


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[PMID]:27727268
[Au] Autor:Mutebi F; von Samson-Himmelstjerna G; Feldmeier H; Waiswa C; Bukeka Muhindo J; Krücken J
[Ad] Endereço:School of Veterinary Medicine and Animal Resources, College of Veterinary Medicine, Animal Resources and Bio-security, Makerere University, Kampala, Uganda.
[Ti] Título:Successful Treatment of Severe Tungiasis in Pigs Using a Topical Aerosol Containing Chlorfenvinphos, Dichlorphos and Gentian Violet.
[So] Source:PLoS Negl Trop Dis;10(10):e0005056, 2016 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In endemic communities, zoonotic tungiasis, a severe skin disease caused by penetrating female sand fleas, is a public health hazard causing significant human and animal morbidity. No validated drugs are currently available for treatment of animal tungiasis. Due to the reservoir in domestic animals, integrated management of human and animal tungiasis is required to avert its negative effects. METHODS AND PRINCIPAL FINDINGS: A topical aerosol containing chlorfenvinphos 4.8%, dichlorphos 0.75% and gentian violet 0.145% licensed to treat tick infestations, myiasis and wound sepsis in animals in the study area, was tested for its potential tungicidal effects in a randomized controlled field trial against pig tungiasis in rural Uganda. Animals with at least one embedded flea were randomized in a treatment (n = 29) and a control (n = 26) group. One week after treatment, 58.6% of the treated pigs did not show any viable flea lesion whereas all control pigs had at least one viable lesion. After treatment the number of viable lesions (treated median = 0, overall range = 0-18 vs. control median = 11.5, range = 1-180) and the severity score for estimating acute pathology in pig tungiasis (treated median = 1, range = 0-3.5 vs. control median = 7, range = 0-25) were significantly lower in treated than in control pigs (p < 0.001). In the treatment group the median number of viable flea lesions decreased from 8.5 to 0 (p < 0.001). Similarly, the median acute severity score dropped from 6 to 1 (p < 0.001). Every pig in the treatment group showed a decrease in the number of viable fleas and tungiasis-associated acute morbidity while medians for both increased in the control group. CONCLUSIONS: The study demonstrates that a topical treatment based on chlorfenvinphos, dichlorphos and gentian violet is highly effective against pig tungiasis. Due to its simplicity, the new approach can be used for the treatment of individual animals as well as in mass campaigns.
[Mh] Termos MeSH primário: Aerossóis/uso terapêutico
Anti-Infecciosos Locais/administração & dosagem
Clorfenvinfos/administração & dosagem
Infestações por Pulgas/tratamento farmacológico
Violeta de Genciana/administração & dosagem
Inseticidas/administração & dosagem
Doenças dos Suínos/tratamento farmacológico
Tunga/efeitos dos fármacos
Tungíase/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Tópica
Animais
Clorfenvinfos/efeitos adversos
Reservatórios de Doenças
Combinação de Medicamentos
Feminino
Seres Humanos
Inseticidas/efeitos adversos
Masculino
Sus scrofa
Suínos
Doenças dos Suínos/parasitologia
Tungíase/epidemiologia
Tungíase/parasitologia
Uganda/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Aerosols); 0 (Anti-Infective Agents, Local); 0 (Drug Combinations); 0 (Insecticides); F2G9XS1W91 (Chlorfenvinphos); J4Z741D6O5 (Gentian Violet)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161012
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005056


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[PMID]:27183059
[Au] Autor:Baas J; Vijver M; Rambohul J; Dunbar M; van 't Zelfde M; Svendsen C; Spurgeon D
[Ad] Endereço:Centre for Ecology and Hydrology, MacLean Building, Wallingford, Oxfordshire, United Kingdom.
[Ti] Título:Comparison and evaluation of pesticide monitoring programs using a process-based mixture model.
[So] Source:Environ Toxicol Chem;35(12):3113-3123, 2016 Dec.
[Is] ISSN:1552-8618
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A number of European countries run large-scale pesticide monitoring schemes in watersheds aimed at identifying and evaluating the presence of pesticide residues in the environment. These schemes provide national and regional scale assessments of pesticide concentrations within the context of environmental quality assessment, aiming to ensure some degree of ecological protection. The present study is aimed at evaluating the joint effects of the pesticide mixtures detected in monitoring programs, using a process-based mixture model that was parameterized for Daphnia magna. In total, over 15 000 samples containing over 1 million individual measurements were evaluated for effects. It was found that there are only a small number of places where one can expect to have effects on daphnids, based on measured concentrations. The most polluted samples would cause extinction of a daphnid population within only 30 h. The results show that effects are mostly triggered by a limited number of pesticide residues at locations with high emissions. It was also shown that the analytical detection limits are basically too high to exclude mixture effects. So, despite all the effort that is put into chemical monitoring programs, it remains a challenge to make statements on whether or not the environment is protected. Recommendations are offered for a different setup of monitoring programs to improve this situation. Environ Toxicol Chem 2016;35:3113-3123. © 2016 SETAC.
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Modelos Teóricos
Avaliação de Programas e Projetos de Saúde
[Mh] Termos MeSH secundário: Animais
Azirinas/análise
Azirinas/toxicidade
Clorfenvinfos/análise
Clorfenvinfos/toxicidade
Daphnia/efeitos dos fármacos
Daphnia/fisiologia
Di-Hidropiridinas/análise
Di-Hidropiridinas/toxicidade
Europa (Continente)
Dose Letal Mediana
Limite de Detecção
Resíduos de Praguicidas/análise
Resíduos de Praguicidas/toxicidade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Azirines); 0 (Dihydropyridines); 0 (Pesticide Residues); 135330-18-6 (diazipine); F2G9XS1W91 (Chlorfenvinphos)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160517
[St] Status:MEDLINE
[do] DOI:10.1002/etc.3492


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[PMID]:26778435
[Au] Autor:Officioso A; Manna C; Alzoubi K; Lang F
[Ad] Endereço:Department of Physiology, University of Tübingen, Gmelinstr. 5, 72076 Tuebingen, Germany; Department of Biochemistry, Biophysics and General Pathology, School of Medicine and Surgery, Second University of Naples, Via L. De Crecchio 7, 80138 Naples, Italy.
[Ti] Título:Bromfenvinphos induced suicidal death of human erythrocytes.
[So] Source:Pestic Biochem Physiol;126:58-63, 2016 Jan.
[Is] ISSN:1095-9939
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The organophosphorus pesticide bromfenvinphos ((E,Z)-O,O-diethyl-O-[1-(2,4-dichlorophenyl)-2-bromovinyl] phosphate) has been shown to decrease hematocrit and hemoglobin levels in blood presumably by triggering oxidative stress of erythrocytes. Oxidative stress is known to activate erythrocytic Ca(2+) permeable unselective cation channels leading to Ca(2+) entry and increase of cytosolic Ca(2+) activity ([Ca(2+)]i), which in turn triggers eryptosis, the suicidal death characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. The present study explored, whether and how bromfenvinphos induces eryptosis. To this end, phosphatidylserine exposure at the cell surface was estimated from annexin-V-binding, cell volume from forward scatter, hemolysis from hemoglobin release, [Ca(2+)]i from Fluo3-fluorescence, and ROS formation from DCFDA dependent fluorescence. As a result, a 48hour exposure of human erythrocytes to bromfenvinphos (≥100µM) significantly increased the percentage of annexin-V-binding cells, significantly decreased forward scatter, significantly increased Fluo3-fluorescence, and significantly increased DCFDA fluorescence. The effect of bromfenvinphos on annexin-V-binding and forward scatter was significantly blunted, but not abolished by removal of extracellular Ca(2+). In conclusion, bromfenvinphos triggers cell shrinkage and phospholipid scrambling of the erythrocyte cell membrane, an effect in part due to stimulation of ROS formation and Ca(2+) entry.
[Mh] Termos MeSH primário: Clorfenvinfos/análogos & derivados
Eritrócitos/efeitos dos fármacos
Inseticidas/toxicidade
[Mh] Termos MeSH secundário: Cálcio/metabolismo
Morte Celular/efeitos dos fármacos
Clorfenvinfos/toxicidade
Eritrócitos/metabolismo
Hemólise/efeitos dos fármacos
Seres Humanos
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insecticides); 0 (Reactive Oxygen Species); 33399-00-7 (bromfenvinphos); F2G9XS1W91 (Chlorfenvinphos); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160119
[St] Status:MEDLINE


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[PMID]:26727991
[Au] Autor:Vudriko P; Okwee-Acai J; Tayebwa DS; Byaruhanga J; Kakooza S; Wampande E; Omara R; Muhindo JB; Tweyongyere R; Owiny DO; Hatta T; Tsuji N; Umemiya-Shirafuji R; Xuan X; Kanameda M; Fujisaki K; Suzuki H
[Ad] Endereço:Department of Veterinary Pharmacy, Clinics and Comparative Medicine, School of Veterinary Medicine and Animal Resources, College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, P. O Box 7062, Kampala, Uganda. vpato@covab.mak.ac.ug.
[Ti] Título:Emergence of multi-acaricide resistant Rhipicephalus ticks and its implication on chemical tick control in Uganda.
[So] Source:Parasit Vectors;9:4, 2016 Jan 04.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Acaricide failure has been on the rise in the western and central cattle corridor of Uganda. In this study, we identified the tick species associated with acaricide failure and determined their susceptibility to various acaricide molecules used for tick control in Uganda. METHODS: In this cross sectional study, tick samples were collected and identified to species level from 54 purposively selected farms (from 17 districts) that mostly had a history of acaricide failure. Larval packet test was used to screen 31 tick populations from 30 farms for susceptibility at discriminating dose (DD) and 2 × DD of five panels of commercial acaricide molecules belonging to the following classes; amidine, synthetic pyrethroid (SP), organophosphate (OP) and OP-SP co-formulations (COF). Resistance was assessed based on World Health Organization criteria for screening insecticide resistance. RESULTS: Of the 1357 ticks identified, Rhipicephalus (Rhipicephalus) appendiculatus and Rhipicephalus (Boophilus) decoloratus were the major (95.6%) tick species in farms sampled. Resistance against SP was detected in 90.0% (27/30) of the tick populations tested. Worryingly, 60.0% (18/30) and 63.0% (19/30) of the above ticks were super resistant (0% mortality) against 2 × DD cypermethrin and deltamethrin, respectively. Resistance was also detected against COF (43.3%), OP chlorfenvinphos (13.3%) and amitraz (12.9%). In two years, 74.1% (20/27) of the farms had used two to three acaricide molecules, and 55.6% (15/27) rotated the molecules wrongly. Multi-acaricide resistance (at least 2 molecules) was detected in 55.2% (16/29) of the resistant Rhipicephalus ticks and significantly associated with R. decoloratus (p = 0.0133), use of both SP and COF in the last 2 years (p < 0.001) and Kiruhura district (p = 0.0339). Despite emergence of amitraz resistance in the greater Bushenyi area, it was the most efficacious molecule against SP and COF resistant ticks. CONCLUSION: This study is the first to report emergence of super SP resistant and multi-acaricide resistant Rhipicephalus ticks in Uganda. Amitraz was the best acaricide against SP and COF resistant ticks. However, in the absence of technical interventions, farmer-led solutions aimed at troubleshooting for efficacy of multitude of acaricides at their disposal are expected to potentially cause negative collateral effects on future chemical tick control options, animal welfare and public health.
[Mh] Termos MeSH primário: Acaricidas/farmacologia
Doenças dos Bovinos/prevenção & controle
Resistência a Múltiplos Medicamentos
Rhipicephalus/efeitos dos fármacos
Controle de Ácaros e Carrapatos/métodos
Infestações por Carrapato/veterinária
[Mh] Termos MeSH secundário: Animais
Bovinos
Doenças dos Bovinos/epidemiologia
Clorfenvinfos/farmacologia
Estudos Transversais
Feminino
Larva
Nitrilos/farmacologia
Organofosfatos/farmacologia
Piretrinas/farmacologia
Infestações por Carrapato/epidemiologia
Infestações por Carrapato/prevenção & controle
Toluidinas/farmacologia
Uganda/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acaricides); 0 (Nitriles); 0 (Organophosphates); 0 (Pyrethrins); 0 (Toluidines); 1TR49121NP (cypermethrin); 2JTS8R821G (decamethrin); 33IAH5017S (amitraz); F2G9XS1W91 (Chlorfenvinphos)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160106
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-015-1278-3


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[PMID]:26423556
[Au] Autor:Boi M; Serra G; Colombo R; Lodesani M; Massi S; Costa C
[Ad] Endereço:Consiglio per la ricerca in agricoltura e l'analisi dell'economia agraria, Unità di ricerca di apicoltura e bachicoltura, Bologna, Italy.
[Ti] Título:A 10 year survey of acaricide residues in beeswax analysed in Italy.
[So] Source:Pest Manag Sci;72(7):1366-72, 2016 Jul.
[Is] ISSN:1526-4998
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of this work was to provide an overview of the prevalence and level of acaricides in beeswax used in Italy in the past 10 years by analysing 1319 beeswax samples processed by the certified laboratory of the Italian Bee Research Institute. RESULTS: The proportion of samples positive to at least one active ingredient decreased between 2005 and 2009 (from 69 to 32%) and then increased again between 2009 and 2014 (from 32 to 91%). This trend is in agreement with reports from beekeepers that the use of synthetic acaricides decreased in the second half of the past decade and increased after the beginning of the colony losses phenomenon. The active ingredient with the greatest overall proportion of positive samples was coumaphos (49%), followed by fluvalinate (38%) and chlorphenvinphos (25%). The indicator for amitraz, 2,4-dimethylphenylformamide (DMPF), was detected in a very small proportion of samples (6%), while residues of cymiazole were never found. CONCLUSIONS: In more than half of the analysed samples, residues of at least one active ingredient were detected. The mean levels of residues of all the considered active ingredients in the positive samples may represent a source of accumulation in beeswax and pose risks to honey bee health. © 2015 Society of Chemical Industry.
[Mh] Termos MeSH primário: Acaricidas/química
Resíduos de Praguicidas/análise
Ceras/química
[Mh] Termos MeSH secundário: Clorfenvinfos/química
Cumafos/química
Itália
Nitrilos/química
Piretrinas/química
Inquéritos e Questionários
Tiazóis/química
Toluidinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Nitriles); 0 (Pesticide Residues); 0 (Pyrethrins); 0 (Thiazoles); 0 (Toluidines); 0 (Waxes); 33IAH5017S (amitraz); 364G5G03VC (fluvalinate); 7XR6MQQ6BK (cymiazole); 8012-89-3 (beeswax); F2G9XS1W91 (Chlorfenvinphos); L08SZ5Z5JC (Coumaphos)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170228
[Lr] Data última revisão:
170228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151002
[St] Status:MEDLINE
[do] DOI:10.1002/ps.4161


  9 / 204 MEDLINE  
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[PMID]:25919192
[Au] Autor:Browne MA; Dissanayake A; Galloway TS
[Ad] Endereço:School of Biological, Earth & Environmental Sciences, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: browne@nceas.ucsb.edu.
[Ti] Título:Organophosphorous biocides reduce tenacity and cellular viability but not esterase activities in a non-target prosobranch (limpet).
[So] Source:Environ Pollut;203:208-13, 2015 Aug.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Detecting impacts of organophosphorus biocides (OP) is facilitated by analysing "biomarkers" - biological responses to environmental insults. Understanding is hampered by studying biomarkers in isolation at different levels of biological response and limited work on ecologically-important species. We tested the relevance of esterases as biomarkers of OP-exposure in limpets (Patella vulgata), abundant prosobranchs that structure the assemblages on rocky shores through their grazing. We characterized esterases in haemolymph and tissue, and quantified their dose-dependent inhibition by chlorfenvinphos (0.1-3.0 mM) in vitro. To determine whether esterases are useful biomarkers we exposed limpets to chlorfenvinphos (0-10 µg L(-1)). Despite reduced tenacity (ability to stick to a surface) and haemocyte-viability, esterases remained unaffected. Tenacity was reduced by >50% at 5 µg L(-1) and by 95% at 10 µg L(-1), whilst haemocyte-viability was more sensitive with >40% reductions at concentrations of 0.5 µg L(-1) and above. We discuss results in relation to linking sub-lethal and ecological impacts at contaminated sites.
[Mh] Termos MeSH primário: Clorfenvinfos/toxicidade
Desinfetantes/toxicidade
Esterases/metabolismo
Gastrópodes/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Biomarcadores/metabolismo
Exposição Ambiental/análise
Monitoramento Ambiental
Gastrópodes/enzimologia
Hemolinfa/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Disinfectants); EC 3.1.- (Esterases); F2G9XS1W91 (Chlorfenvinphos)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150530
[Lr] Data última revisão:
150530
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150429
[St] Status:MEDLINE


  10 / 204 MEDLINE  
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[PMID]:25752429
[Au] Autor:Sosnowska B; Huras B; Bukowska B
[Ad] Endereço:Department of Biophysics of Environmental Pollution, University of Lodz, Lodz, Poland; Department of Hypertension, Medical University of Lodz, Lodz, Poland. Electronic address: bozena.szatkowska@gmail.com.
[Ti] Título:Oxidative stress in human erythrocytes treated with bromfenvinphos and its impurities.
[So] Source:Pestic Biochem Physiol;118:43-9, 2015 Feb.
[Is] ISSN:1095-9939
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bromfenvinphos (BFVF) is an organophosphorus (OP) pesticide which was widely used in agriculture and veterinary practice. During synthesis of this insecticide five main impurities are formed: dihydro-bromfenvinphos, dibromo-bromfenvinphos, 2,4-dichlorophenacyl bromide, 2,4-dichlorophenacylidene bromide and 2,4-dichlorophenacylidyne bromide, which can be present in technical grade bromfenvinphos in amounts from 0.1 to 4%. The aim of this study was to examine the influence of bromfenvinphos and its manufacturing impurities on parameters of oxidative stress, the activity of antioxidative enzymes and the level of reduced glutathione. Human erythrocytes were incubated with bromfenvinphos and its impurities in the concentrations range from 0.5 to 500 µM for 1 h. This study indicated that 2,4-dichlorophenacyl derivatives more strongly oxidized analyzed parameters in human erythrocytes than bromfenvinphos. Investigated compounds caused an increase in lipid peroxidation and oxidation of fluorescent probe DCFH2 - the strongest pro-oxidative changes were provoked by 2,4-dichlorophenacyl bromide. None of the compounds studied in the concentrations from 0.5 to 500 µM changed the activity of SOD and only 2,4-dichlorophenacyl decreased activity of CAT. The level of GSH was only altered by 2,4-dichlorophenacyl derivatives. It was observed that increasing number of bromine atoms in the side chain of those derivatives was associated with decreased GSH level.
[Mh] Termos MeSH primário: Clorfenvinfos/análogos & derivados
Eritrócitos/metabolismo
Inseticidas/toxicidade
Estresse Oxidativo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Clorfenvinfos/química
Clorfenvinfos/toxicidade
Eritrócitos/efeitos dos fármacos
Eritrócitos/enzimologia
Glutationa/metabolismo
Glutationa Peroxidase/metabolismo
Seres Humanos
Inseticidas/química
Estrutura Molecular
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insecticides); 33399-00-7 (bromfenvinphos); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); F2G9XS1W91 (Chlorfenvinphos); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:150310
[Lr] Data última revisão:
150310
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150311
[St] Status:MEDLINE



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