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[PMID]:26210825
[Au] Autor:Bavili Tabrizi A; Abdollahi A
[Ad] Endereço:Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. a.bavili@tbzmed.ac.ir.
[Ti] Título:Determination of Organothiophosphate Insecticides in Environmental Water Samples by a Very Simple and Sensitive Spectrofluorimetric Method.
[So] Source:Bull Environ Contam Toxicol;95(4):536-41, 2015 Oct.
[Is] ISSN:1432-0800
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A simple, rapid and sensitive spectrofluorimetric method was developed for the determination of di-syston, ethion and phorate in environmental water samples. The procedure is based on the oxidation of these pesticides with cerium (IV) to produce cerium (III), and its fluorescence was monitored at 368 ± 3 nm after excitation at 257 ± 3 nm. The variables effecting oxidation of each pesticide were studied and optimized. Under the experimental conditions used, the calibration graphs were linear over the range 0.2-15, 0.1-13, 0.1-13 ng mL(-1) for di-syston, ethion and phorate, respectively. The limit of detection and quantification were in the range 0.034-0.096 and 0.112-0.316 ng mL(-1), respectively. Intra- and inter-day assay precisions, expressed as the relative standard deviation (RSD), were lower than 5.2 % and 6.7 %, respectively. Good recoveries in the range 86 %-108 % were obtained for spiked water samples. The proposed method was applied to the determination of studied pesticides in environmental water samples.
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Inseticidas/análise
Qualidade da Água
[Mh] Termos MeSH secundário: Dissulfóton/análise
Dissulfóton/química
Inseticidas/química
Compostos Organotiofosforados/análise
Compostos Organotiofosforados/química
Forato/análise
Forato/química
Espectrometria de Fluorescência/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Organothiophosphorus Compounds); 2TI07NO12Y (ethion); 3CY5EKL6MT (Disulfoton); 3W54X3W9IV (Phorate)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:150919
[Lr] Data última revisão:
150919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150727
[St] Status:MEDLINE
[do] DOI:10.1007/s00128-015-1612-7


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[PMID]:22818267
[Au] Autor:Usui K; Hayashizaki Y; Minagawa T; Hashiyada M; Nakano A; Funayama M
[Ad] Endereço:Division of Forensic Medicine, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan. usui@forensic.med.tohoku.ac.jp
[Ti] Título:Rapid determination of disulfoton and its oxidative metabolites in human whole blood and urine using QuEChERS extraction and liquid chromatography-tandem mass spectrometry.
[So] Source:Leg Med (Tokyo);14(6):309-16, 2012 Nov.
[Is] ISSN:1873-4162
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:A liquid chromatography-tandem mass spectrometry method was developed and validated for simultaneous determination of disulfoton and five of its oxidative metabolites (disulfoton-sulfoxide, disulfoton-sulfone, demeton-S, demeton-S-sulfoxide and demeton-S-sulfone) in human whole blood and urine. Extraction was undertaken using a QuEChERS method, which is commonly used in food analysis. D10-Disulfoton was used as the internal standard. Separation was carried out using a CAPCELL-PAK MG II column (35×2.0 mm i.d., 5 µm, Shiseido) with a mobile phase of 10 m mol/L ammonium formate and methanol. This method was applied in an autopsy case, and disulfoton and its oxidative metabolites were successfully detected in both blood and urine. The concentrations of disulfoton in the blood and urine were 360 and 23.8 ng/mL, respectively. There was a relatively low concentration of demeton-S in both the blood (4.0 ng/mL) and urine (45.7 ng/mL). To date, there have been no reported cases of detection of demeton-S in human samples.
[Mh] Termos MeSH primário: Dissulfóton/sangue
Dissulfóton/urina
[Mh] Termos MeSH secundário: Idoso
Cromatografia Líquida
Seres Humanos
Inseticidas/sangue
Inseticidas/urina
Masculino
Suicídio
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 3CY5EKL6MT (Disulfoton)
[Em] Mês de entrada:1302
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120724
[St] Status:MEDLINE


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[PMID]:21710164
[Au] Autor:Lisker EB; Ensminger MP; Gill SL; Goh KS
[Ad] Endereço:Environmental Monitoring Branch, Department of Pesticide Regulation, California Environmental Protection Agency, 1001 I Street, Sacramento, CA 95814, USA. elisker@cdpr.ca.gov
[Ti] Título:Detections of eleven organophosphorus insecticides and one herbicide threatening Pacific salmonids, Oncorhynchus spp., in California, 1991-2010.
[So] Source:Bull Environ Contam Toxicol;87(4):355-60, 2011 Oct.
[Is] ISSN:1432-0800
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:California's surface water monitoring results from 1991 through 2010 were analyzed to determine whether 12 organophosphorus insecticides and herbicides (i.e., azinphos methyl, bensulide, dimethoate, disulfoton, ethoprop, fenamiphos, methamidophos, methidathion, methyl parathion, naled, phorate, and phosmet) and their degradates have been detected above maximum concentration limits (MCLs) in Pacific salmonid habitats. Methidathion, methyl parathion, phorate, phosmet, and the oxygen analogue of naled (DDVP) detections exceeded MCLs. Methyl parathion detections may be accounted for by monthly use trends, while methidathion detections may be explained by yearly use trends. There were inadequate phorate, phosmet, or DDVP data to evaluate for correlations with use.
[Mh] Termos MeSH primário: Herbicidas/metabolismo
Inseticidas/metabolismo
Oncorhynchus/metabolismo
Compostos Organofosforados/metabolismo
Poluentes Químicos da Água/metabolismo
[Mh] Termos MeSH secundário: Animais
California
Dissulfóton/análise
Dissulfóton/metabolismo
Monitoramento Ambiental
Água Doce/análise
Água Doce/química
Herbicidas/análise
Inseticidas/análise
Metil Paration/análise
Metil Paration/metabolismo
Compostos Organofosforados/análise
Organotiofosfatos/análise
Organotiofosfatos/metabolismo
Compostos Organotiofosforados/análise
Compostos Organotiofosforados/metabolismo
Oceano Pacífico
Forato/análise
Forato/metabolismo
Poluentes Químicos da Água/análise
Poluição Química da Água/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Herbicides); 0 (Insecticides); 0 (Organophosphorus Compounds); 0 (Organothiophosphates); 0 (Organothiophosphorus Compounds); 0 (Water Pollutants, Chemical); 13194-48-4 (ethoprop); 3CY5EKL6MT (Disulfoton); 3W54X3W9IV (Phorate); 41BCL2O91D (Methyl Parathion); 8Z083FM94W (methamidophos); 9882BW2Q2S (bensulide); H4NO3L2HBE (fenamiphos); Y2P145U7KK (methidathion)
[Em] Mês de entrada:1112
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110629
[St] Status:MEDLINE
[do] DOI:10.1007/s00128-011-0351-7


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[PMID]:20441911
[Au] Autor:Momplaisir GM; Rosal CG; Heithmar EM; Varner KE; Riddick LA; Bradford DF; Tallent-Halsell NG
[Ad] Endereço:U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, Environmental Chemistry Branch, Las Vegas, NV 89193-3478, USA. momplaisir.georges-marie@epa.gov
[Ti] Título:Development of a solid phase extraction method for agricultural pesticides in large-volume water samples.
[So] Source:Talanta;81(4-5):1380-6, 2010 Jun 15.
[Is] ISSN:1873-3573
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:An analytical method using solid phase extraction (SPE) and analysis by gas chromatography/mass spectrometry (GC-MS) was developed to determine trace levels of a variety of 41 agricultural pesticides and selected transformation products in high-elevation surface waters. Large-volume water sampling (up to 100L) was employed because it was anticipated that pesticide contamination, if present, would be at very low levels. The target compounds comprise pesticides (and selected oxygen transformation products) known to have been extensively used in agriculture in the San Joaquin Valley, CA, USA. Solid phase extraction using the polymeric resin Abselut Nexus was optimized to extract the pesticide analytes from water samples. A single determinative method using GC-MS with electron ionization was used for all the analytes. Recoveries from 100L of reagent water at 100pg/L and 1ng/L concentrations were generally greater than 75%, although dimethoate, disulfoton, and phorate were not recovered. Analysis of the extracts without cleanup yielded detection limits for the remaining 38 analytes between 0.1 and 30ng/L. A silica cleanup with separate analysis of 3 eluant fractions improved detection limits for 37 of the compounds to between 6 and 600pg/L in high-elevation surface waters.
[Mh] Termos MeSH primário: Técnicas de Química Analítica
Resíduos de Praguicidas/análise
Praguicidas/análise
Extração em Fase Sólida/métodos
Purificação da Água/métodos
Água/química
[Mh] Termos MeSH secundário: Absorção
Agricultura/métodos
Dimetoato/análise
Dissulfóton/análise
Cromatografia Gasosa-Espectrometria de Massas/métodos
Resíduos de Praguicidas/isolamento & purificação
Praguicidas/isolamento & purificação
Forato/análise
Dióxido de Silício/química
Temperatura Ambiente
Poluentes da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Pesticide Residues); 0 (Pesticides); 0 (Water Pollutants); 059QF0KO0R (Water); 3CY5EKL6MT (Disulfoton); 3W54X3W9IV (Phorate); 7631-86-9 (Silicon Dioxide); W6U08B045O (Dimethoate)
[Em] Mês de entrada:1010
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100506
[St] Status:MEDLINE
[do] DOI:10.1016/j.talanta.2010.02.038


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[PMID]:18493924
[Au] Autor:Yasuor H; TenBrook PL; Tjeerdema RS; Fischer AJ
[Ad] Endereço:Weed Science Program, Department of Plant Sciences, University of California, Davis, CA 95616, USA. hyasuor@ucdavis.edu
[Ti] Título:Responses to clomazone and 5-ketoclomazone by Echinochloa phyllopogon resistant to multiple herbicides in Californian rice fields.
[So] Source:Pest Manag Sci;64(10):1031-9, 2008 Oct.
[Is] ISSN:1526-498X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Late watergrass [Echinochloa phyllopogon (Stapf.) Koss.] is a major weed of Californian rice that has evolved P450-mediated metabolic resistance to multiple herbicides. Resistant (R) populations are also poorly controlled by the recently introduced herbicide clomazone. The authors assessed whether this cross-resistance was also P450 mediated, and whether R plants also had reduced sensitivity to photooxidation. Understanding mechanism(s) of resistance facilitates the design of herbicide management strategies to delay resistance evolution. RESULTS: Ratios (R/S) of R to susceptible (S) GR(50) were near 2.0. [(14)C]Clomazone uptake was similar in R and S plants. Clomazone and its metabolite 5-ketoclomazone reduced chlorophyll and carotenoids in S more than in R plants. The P450 inhibitors disulfoton and 1-aminobenzo-triazole (ABT) safened clomazone in R and S plants. Disulfoton safened 5-ketoclomazone only in S plants, while ABT synergized 5-ketoclomazone mostly against S plants. Paraquat was more toxic in S than in R plants. CONCLUSION: Cross-resistance to clomazone explains failures to control R plants in rice fields, and safening by P450 inhibitors suggests that oxidative activation of clomazone is needed for toxicity to E. phyllopogon. Clomazone resistance requires mitigation of 5-ketoclomazone toxicity, but P450 detoxification may not significantly confer resistance, as P450 inhibitors poorly synergized 5-ketoclopmazone in R plants. Responses to paraquat suggest research on mechanisms to mitigate photooxidation in R and S plants is needed.
[Mh] Termos MeSH primário: Echinochloa/efeitos dos fármacos
Resistência a Herbicidas
Herbicidas/farmacologia
Isoxazóis/farmacologia
Oryza
Oxazolidinonas/farmacologia
[Mh] Termos MeSH secundário: Biomassa
California
Inibidores das Enzimas do Citocromo P-450
Sistema Enzimático do Citocromo P-450/metabolismo
Dissulfóton/farmacologia
Echinochloa/fisiologia
Inibidores Enzimáticos/farmacologia
Paraquat/farmacologia
Pigmentos Biológicos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (5-ketoclomazone); 0 (Cytochrome P-450 Enzyme Inhibitors); 0 (Enzyme Inhibitors); 0 (Herbicides); 0 (Isoxazoles); 0 (Oxazolidinones); 0 (Pigments, Biological); 3CY5EKL6MT (Disulfoton); 570RAC03NF (clomazone); 9035-51-2 (Cytochrome P-450 Enzyme System); PLG39H7695 (Paraquat)
[Em] Mês de entrada:0811
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080522
[St] Status:MEDLINE
[do] DOI:10.1002/ps.1604


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[PMID]:18227081
[Au] Autor:Lynch AM; Robinson SA; Wilcox P; Smith MD; Kleinman M; Jiang K; Rees RW
[Ad] Endereço:Genetic Toxicology, GlaxoSmithKline R&D, Ware, Hertfordshire SG12 0DP, UK. anthony.m.lynch@gsk.com
[Ti] Título:Cycloheximide and disulfoton are positive in the photoclastogencity assay but do not absorb UV irradiation: another example of pseudophotoclastogenicity?
[So] Source:Mutagenesis;23(2):111-8, 2008 Mar.
[Is] ISSN:1464-3804
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:There is considerable concern regarding the biological plausibility of the response of certain chemicals in the in vitro photoclastogenicity assay, suggesting that this assay is oversensitive and lacks specificity. To explore this further, four coded compounds (aminotriazole, propantheline bromide, cycloheximide and disulfoton) were evaluated for their potential response in a photoclastogenicity assay in cultured Chinese hamster ovary (CHO) cells. None of the four compounds were shown to absorb ultraviolet radiation (UVR) or visible light in the 290- to 700-nm region of the electromagnetic spectrum. A fifth coded compound, tetracycline, which absorbs UVR, was also tested as this has previously been shown to be phototoxic in vitro (3T3-NRU assay) and is cytotoxic, but not genotoxic, at high concentrations in standard 'dark' genotoxicity assays in mammalian cells. The results showed that cycloheximide, disulfoton and tetracycline were clastogenic in CHO cells following UVR exposure (solar-simulated light at 700 mJ/cm(2)) but not in the absence of UVR. Aminotriazole and propantheline were negative in the presence and absence of UVR exposure. Follow-up testing showed that neither cycloheximide nor disulfoton was positive in the 3T3-NRU assay, the standard in vitro regulatory test for phototoxicity, a result consistent with their inability to absorb UVR. These data suggest that both cycloheximide and disulfoton are pseudophotoclastogens, like zinc oxide. Together, these data question the specificity of the in vitro photoclastogencity assay in CHO cells and raises further concern regarding its use for the assessment of chemical photosafety for regulatory purposes. At the very least, a review of the current guidance documents for the photosafety evaluation of pharmaceuticals and cosmetics should be undertaken urgently.
[Mh] Termos MeSH primário: Aberrações Cromossômicas
Cicloeximida/toxicidade
Dissulfóton/toxicidade
Testes de Mutagenicidade/normas
Mutagênicos
Raios Ultravioleta
[Mh] Termos MeSH secundário: Amitrol (Herbicida)/toxicidade
Animais
Células CHO
Cricetinae
Cricetulus
Dano ao DNA
Propantelina/toxicidade
Tetraciclina/toxicidade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mutagens); 1306V2B0Q8 (Propantheline); 3CY5EKL6MT (Disulfoton); 98600C0908 (Cycloheximide); F8VB5M810T (Tetracycline); ZF80H5GXUF (Amitrole)
[Em] Mês de entrada:0804
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080130
[St] Status:MEDLINE
[do] DOI:10.1093/mutage/gem053


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[PMID]:18036377
[Au] Autor:Basheer C; Alnedhary AA; Rao BS; Lee HK
[Ad] Endereço:Department of Chemistry, National University of Singapore, 3 Science Drive 3, Republic of Singapore 117543.
[Ti] Título:Determination of organophosphorous pesticides in wastewater samples using binary-solvent liquid-phase microextraction and solid-phase microextraction: a comparative study.
[So] Source:Anal Chim Acta;605(2):147-52, 2007 Dec 19.
[Is] ISSN:1873-4324
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A simple and efficient binary solvent-based two-phase hollow fiber membrane (HFM)-protected liquid-phase microextraction (BN-LPME) technique for moderately polar compounds was developed. Six organophosphorous pesticides (OPPs) (triethylphosphorothioate, thionazin, sulfotep, phorate, disulfoton, methyl parathion and ethyl parathion) were used as model compounds and extracted from 10-mL wastewater with a binary-solvent (toluene:hexane, 1:1) mixture. Some important extraction parameters, such as extraction time, effect of salt, sample pH and solvent ratio composition were optimized. BN-LPME combined with gas chromatography/mass spectrometric (GC/MS) analysis provided repeatability (R.S.D.s < or = 12%, n = 4), and linearity (r < or = 0.994) and solid-phase microextraction provides comparable of R.S.D.s < or = 13%, n = 4 and linearity (r < or = 0.966) for spiked water samples. The limits of detection (LODs) were in the range of 0.3-11.4 ng L(-1) for BN-LPME and 3.1-120.5 ng L(-1) for SPME at (S/N = 3) under GC/MS selective ion monitoring mode. In addition to high enrichment, BN-LPME also served as a sample cleanup procedure, with the HFM act as a filtering medium to prevent large particles and extraneous materials from being extracted. To investigate and compare their applicability, the BN-LPME and SPME procedures were applied to the detection of OPPs in domestic wastewater samples.
[Mh] Termos MeSH primário: Técnicas de Química Analítica/métodos
Resíduos de Praguicidas/análise
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Dissulfóton/análise
Cromatografia Gasosa-Espectrometria de Massas/métodos
Herbicidas/análise
Metil Paration/análise
Compostos Organofosforados/análise
Organotiofosfatos/análise
Compostos Organotiofosforados/análise
Paration/análise
Forato/análise
Reprodutibilidade dos Testes
Microextração em Fase Sólida
Solventes
Purificação da Água
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Herbicides); 0 (Organophosphorus Compounds); 0 (Organothiophosphates); 0 (Organothiophosphorus Compounds); 0 (Pesticide Residues); 0 (Solvents); 0 (Water Pollutants, Chemical); 1186-09-0 (O,O,S-triethyl phosphorothioate); 297-97-2 (thionazin); 3CY5EKL6MT (Disulfoton); 3W54X3W9IV (Phorate); 41BCL2O91D (Methyl Parathion); 61G466064D (Parathion); V41BK2EE8X (sulfotepp)
[Em] Mês de entrada:0801
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:071127
[St] Status:MEDLINE


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[PMID]:17849886
[Au] Autor:Johnson TA; Williamson RC
[Ad] Endereço:Department of Entomology, University of Wisconsin, Madison, WI 53706, USA.
[Ti] Título:Potential management strategies for the linden borer (Coleoptera: Cerambycidae) in urban landscapes and nurseries.
[So] Source:J Econ Entomol;100(4):1328-34, 2007 Aug.
[Is] ISSN:0022-0493
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The linden borer, Saperda vestita Say (Coleoptera: Cerambycidae), is a native insect species that is common throughout north central and northeastern North America. Over the past decade, increasing occurrence of damage associated with the linden borer has been reported on Tilia spp. in city street trees and nurseries throughout Wisconsin, probably because of increased use of these trees. Our objective was to gain a better understanding of the seasonal biology and potential management strategies for this important pest. We evaluated the effectiveness of three systemic insecticides, imidacloprid, thiamethoxam, and disulfoton, and a mechanical control method of chipping linden borer-infested wood as a means of reducing S. vestita larval survival, subsequent emergence, and oviposition. Autumn and spring soil injections of imidacloprid to linden borer-infested Tilia cordata'Greenspire' nursery stock (< 11.4 cm in diameter at breast height [dbh]) provided >90% control. Autumn soil injections of imidacloprid and thiamethoxam and a spring granular soil application treatment of disulfoton applied to larger (>22 cm dbh) Tilia spp. did not effectively control linden borer at the application rates tested. Chipping infested Tilia spp. effectively destroyed linden borer larvae, pupae, and adults. Arborists and landscape managers should consider chipping felled Tilia spp. trees infested with S. vestita to prevent adults from potentially attacking nearby susceptible trees.
[Mh] Termos MeSH primário: Coleópteros
Controle de Insetos/métodos
Inseticidas
[Mh] Termos MeSH secundário: Animais
Coleópteros/fisiologia
Dissulfóton
Imidazóis
Larva/fisiologia
Neonicotinoides
Nitrocompostos
Oxazinas
Pupa/fisiologia
Estações do Ano
Tiazóis
Tilia/parasitologia
Wisconsin
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Imidazoles); 0 (Insecticides); 0 (Neonicotinoids); 0 (Nitro Compounds); 0 (Oxazines); 0 (Thiazoles); 3BN7M937V8 (imidacloprid); 3CY5EKL6MT (Disulfoton); 747IC8B487 (thiamethoxam)
[Em] Mês de entrada:0712
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070914
[St] Status:MEDLINE


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[PMID]:17630782
[Au] Autor:Ghanem E; Li Y; Xu C; Raushel FM
[Ad] Endereço:Department of Chemistry, P.O. Box 30012, Texas A&M University, College Station, Texas 77842, USA.
[Ti] Título:Characterization of a phosphodiesterase capable of hydrolyzing EA 2192, the most toxic degradation product of the nerve agent VX.
[So] Source:Biochemistry;46(31):9032-40, 2007 Aug 07.
[Is] ISSN:0006-2960
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes is a nonspecific diesterase that enables Escherichia coli to utilize alkyl phosphodiesters, such as diethyl phosphate, as the sole phosphorus source. The catalytic properties of GpdQ were determined, and the best substrate found was bis(p-nitrophenyl) phosphate with a kcat/Km value of 6.7 x 10(3) M-1 s-1. In addition, the E. aerogenes diesterase was tested as a catalyst for the hydrolysis of a series of phosphonate monoesters which are the hydrolysis products of the highly toxic organophosphonate nerve agents sarin, soman, GF, VX, and rVX. Among the phosphonate monoesters tested, the hydrolysis product of rVX, isobutyl methyl phosphonate, was the best substrate with a kcat/Km value of 33 M-1 s-1. The ability of GpdQ to hydrolyze the phosphonate monoesters provides an alternative selection strategy in the search of enhanced variants of the bacterial phosphotriesterase (PTE) for the hydrolysis of organophosphonate nerve agents. This investigation demonstrated that the previously reported activity of GpdQ toward the hydrolysis of methyl demeton-S is due to the presence of a diester contaminant in the commercial material. Furthermore, it was shown that GpdQ is capable of hydrolyzing a close analogue of EA 2192, the most toxic and persistent degradation product of the nerve agent VX.
[Mh] Termos MeSH primário: Enterobacter aerogenes/enzimologia
Compostos Organotiofosforados/química
Diester Fosfórico Hidrolases/química
[Mh] Termos MeSH secundário: Substâncias para a Guerra Química/química
Substâncias para a Guerra Química/metabolismo
Inibidores da Colinesterase/química
Inibidores da Colinesterase/metabolismo
Dissulfóton/química
Dissulfóton/metabolismo
Enterobacter aerogenes/genética
Enterobacter aerogenes/crescimento & desenvolvimento
Cinética
Viabilidade Microbiana/efeitos dos fármacos
Estrutura Molecular
Mutação
Nitrofenóis/química
Nitrofenóis/metabolismo
Organofosfatos/química
Organofosfatos/metabolismo
Organofosfonatos/química
Organofosfonatos/metabolismo
Compostos Organotiofosforados/metabolismo
Paraoxon/química
Paraoxon/metabolismo
Fenóis/farmacologia
Diester Fosfórico Hidrolases/biossíntese
Diester Fosfórico Hidrolases/metabolismo
Hidrolases de Triester Fosfórico/química
Hidrolases de Triester Fosfórico/genética
Hidrolases de Triester Fosfórico/metabolismo
Proteínas Recombinantes/química
Proteínas Recombinantes/isolamento & purificação
Proteínas Recombinantes/metabolismo
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Chemical Warfare Agents); 0 (Cholinesterase Inhibitors); 0 (Nitrophenols); 0 (Organophosphates); 0 (Organophosphonates); 0 (Organothiophosphorus Compounds); 0 (Phenols); 0 (Recombinant Proteins); 3CY5EKL6MT (Disulfoton); 645-15-8 (bis(4-nitrophenyl)phosphate); 9A4381183B (VX); B9PMD9I0FE (methyl demeton); EC 3.1.4.- (Phosphoric Diester Hydrolases); EC 3.1.4.46 (glycerophosphodiester phosphodiesterase); EC 3.1.8.- (Phosphoric Triester Hydrolases); Q9CX8P80JW (Paraoxon)
[Em] Mês de entrada:0710
[Cu] Atualização por classe:161124
[Lr] Data última revisão:
161124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070717
[St] Status:MEDLINE


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[PMID]:17128880
[Au] Autor:Tanaka Y
[Ad] Endereço:Yokohama City Institute of Health, 1-2-17, Takigashira, Isogo-ku, Yokohama 235-0012, Japan.
[Ti] Título:[Studies of food hygiene about decomposition product from pesticides detected in foods].
[So] Source:Shokuhin Eiseigaku Zasshi;47(5):J315-7, 2006 Oct.
[Is] ISSN:0015-6426
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Análise de Alimentos
Contaminação de Alimentos/análise
Resíduos de Praguicidas/análise
Plastificantes/análise
[Mh] Termos MeSH secundário: Dissulfóton/análise
Alimentos Congelados/análise
Lycopersicon esculentum/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pesticide Residues); 0 (Plasticizers); 3CY5EKL6MT (Disulfoton)
[Em] Mês de entrada:0612
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:061130
[St] Status:MEDLINE



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