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[PMID]:29292090
[Au] Autor:Miyake M; Ito Y; Suzuki H; Tomizawa M; Sato H; Liu M; Okamura A; Nakajima T; Ohtani K; Takino H; Inagaki H; Kamijima M
[Ad] Endereço:Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.
[Ti] Título:Epididymal phospholipidosis is a possible mechanism for spermatotoxicity induced by the organophosphorus insecticide fenitrothion in rats.
[So] Source:Toxicol Lett;285:27-33, 2018 Mar 15.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Fenitrothion (FNT) is used worldwide in agricultural and public health settings. Spermatogenesis is a toxicological target of FNT under high-dose exposure. Although anti-androgenic action is postulated to be the mechanism associated with this toxicity, few studies have examined histopathology of androgen-dependent male accessory sex organs. The present study aimed to reveal the effects of FNT on the accessory organs of rats exhibiting spermatotoxicity in the absence of testicular histopathological changes. Furthermore, a possible novel molecular target was clarified. Male Wistar rats were orally administered 5 or 10 mg/kg FNT or its major metabolite 3-methyl-4-nitrophenol (MNP), or vehicle only, 4 days per week for 9 weeks. Then the epididymis, prostate, and seminal vesicles were collected. FNT and MNP did not show anti-androgenic effects but FNT induced cytoplasmic vacuolation in the epithelial cells of epididymal ducts and hyperplasia of mucosal folds/epithelial papillomatosis in seminal vesicles. FNT and MNP induced epididymal phospholipidosis, which was presumably caused by inhibition of epididymal secreted phospholipase A2 (sPLA2). Percentages of morphologically normal sperm and immature sperm were significantly predicted from both epididymal sPLA2 and phospholipid levels and from epididymal sPLA2, respectively. These results suggest that epididymal phospholipidosis plays an important role in FNT-induced spermatotoxicity. Anti-androgenic actions were not observed.
[Mh] Termos MeSH primário: Epididimo/efeitos dos fármacos
Fenitrotion/toxicidade
Inseticidas/toxicidade
Fosfolipídeos/metabolismo
Espermatogênese/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Epididimo/metabolismo
Epididimo/patologia
Masculino
Fosfolipases A2/metabolismo
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Phospholipids); EC 3.1.1.4 (Phospholipases A2); W8M4X3Y7ZY (Fenitrothion)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE


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[PMID]:28372248
[Au] Autor:Malhat F; Boulangé J; Abdelraheem E; Abd Allah O; Abd El-Hamid R; Abd El-Salam S
[Ad] Endereço:Pesticide Residues and Environmental Pollution Department, Central Agricultural Pesticide Laboratory, Agriculture Research Center, Dokki, Giza 12618, Egypt; Tokyo University of Agricultural and Technology, 3-5-8 Saiwaicho, Fuchu, Tokyo 183-8581, Japan. Electronic address: farag_malhat@yahoo.com.
[Ti] Título:Validation of QuEChERS based method for determination of fenitrothion residues in tomatoes by gas chromatography-flame photometric detector: Decline pattern and risk assessment.
[So] Source:Food Chem;229:814-819, 2017 Aug 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A simple and rapid gas chromatography with flame photometric detector (GC-FPD) determination method was developed to detect residue levels and investigate the dissipation pattern and safe use of fenitrothion in tomatoes. A modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) using an ethyl acetate-based extraction, followed by a dispersive solid-phase extraction (d-SPE) with primary-secondary amine (PSA) and graphite carbon black (GCB) for clean up, was applied prior to GC-FPD analysis. The method showed satisfactory linearity, recovery and precision. The limits of detection (LOD) and quantification (LOQ) were 0.005 and 0.01mg/kg, respectively. The residue levels of fenitrothion were best described by first order kinetics with a half-life of 2.2days in tomatoes. The potential health risks posed by fenitrothion were not significant, based on supervised residue trial data. The current findings could provide guidance for safe and reasonable use of fenitrothion in tomatoes and prevent health problems to consumers.
[Mh] Termos MeSH primário: Fenitrotion/análise
Contaminação de Alimentos
Lycopersicon esculentum/química
Resíduos de Praguicidas/análise
Fotometria/normas
[Mh] Termos MeSH secundário: Cromatografia Gasosa/métodos
Cromatografia Gasosa/normas
Cromatografia Gasosa-Espectrometria de Massas/métodos
Cromatografia Gasosa-Espectrometria de Massas/normas
Limite de Detecção
Fotometria/métodos
Reprodutibilidade dos Testes
Medição de Risco
Extração em Fase Sólida/métodos
Extração em Fase Sólida/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pesticide Residues); W8M4X3Y7ZY (Fenitrothion)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE


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[PMID]:28347352
[Au] Autor:Al Nazawi AM; Aqili J; Alzahrani M; McCall PJ; Weetman D
[Ad] Endereço:Department of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. A.Alnazawi@liverpool.ac.uk.
[Ti] Título:Combined target site (kdr) mutations play a primary role in highly pyrethroid resistant phenotypes of Aedes aegypti from Saudi Arabia.
[So] Source:Parasit Vectors;10(1):161, 2017 Mar 27.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pyrethroid resistance is a threat to effective vector control of Aedes aegypti, the vector of dengue, Zika and other arboviruses, but there are many major knowledge gaps on the mechanisms of resistance. In Jeddah and Makkah, the principal dengue-endemic areas of Saudi Arabia, pyrethroids are used widely for Ae. aegypti control but information about resistance remains sparse, and the underlying genetic basis is unknown. Findings from an ongoing study in this internationally significant area are reported here. METHODS: Aedes aegypti collected from each city were raised to adults and assayed for resistance to permethrin, deltamethrin (with and without the synergist piperonyl butoxide, PBO), fenitrothion, and bendiocarb. Two fragments of the voltage-gated sodium channel (Vgsc), encompassing four previously identified mutation sites, were sequenced and subsequently genotyped to determine associations with resistance. Expression of five candidate genes (CYP9J10, CYP9J28, CYP9J32, CYP9M6, ABCB4) previously associated with pyrethroid resistance was compared between assay survivors and controls. RESULTS: Jeddah and Makkah populations exhibited resistance to multiple insecticides and a similarly high prevalence of resistance to deltamethrin compared to a resistant Cayman strain, with a significant influence of age and exposure duration on survival. PBO pre-exposure increased pyrethroid mortality significantly in the Jeddah, but not the Makkah strain. Three potentially interacting Vgsc mutations were detected: V1016G and S989P were in perfect linkage disequilibrium in each strain and strongly predicted survival, especially in the Makkah strain, but were in negative linkage disequilibrium with 1534C, though some females with the Vgsc triple mutation were detected. The candidate gene CYP9J28 was significantly over-expressed in Jeddah compared to two susceptible reference strains, but none of the candidate genes was consistently up-regulated to a significant level in the Makkah strain. CONCLUSIONS: Despite their proximity, Makkah and Jeddah exhibit significant differences in pyrethroid resistance phenotypes, with some evidence to suggest a different balance of mechanisms, for example with more impact associated with CYP450s in the Jeddah strain, and the dual kdr mutations 989P and 1016G in the more resistant Makkah strain. The results overall demonstrate a major role for paired target site mutations in pyrethroid resistance and highlight their utility for diagnostic monitoring.
[Mh] Termos MeSH primário: Aedes/efeitos dos fármacos
Aedes/genética
Resistência a Inseticidas/genética
Mosquitos Vetores/genética
[Mh] Termos MeSH secundário: Alelos
Animais
Dengue/prevenção & controle
Dengue/virologia
Feminino
Fenitrotion/farmacologia
Genótipo
Mosquitos Vetores/virologia
Mutação
Nitrilos/farmacologia
Permetrina/farmacologia
Fenótipo
Fenilcarbamatos/farmacologia
Butóxido de Piperonila/farmacologia
Piretrinas/farmacologia
Arábia Saudita
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitriles); 0 (Phenylcarbamates); 0 (Pyrethrins); 2JTS8R821G (decamethrin); 509F88P9SZ (Permethrin); LWK91TU9AH (Piperonyl Butoxide); QFH0ZU0A5U (bendiocarb); W8M4X3Y7ZY (Fenitrothion)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170329
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-017-2096-6


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[PMID]:27837361
[Au] Autor:Barcellos M; Faletti MM; Madureira LA; Bauer FC
[Ad] Endereço:Department of Chemistry, Federal University of Santa Catarina, Florianopolis, SC, 88040-900, Brazil. mika_barcellos@yahoo.com.br.
[Ti] Título:Analytical evaluation of the protection offered by sealed tractor cabins during crop pulverization with fenitrothion.
[So] Source:Environ Monit Assess;188(12):660, 2016 Dec.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The practice of large-scale agriculture requires the use of pesticides in order to maximize production. This activity has gained increasing attention in recent years, especially from rural workers, due to the risks associated with long-term exposure to pesticides. To minimize these risks, personal protection equipment (e.g., covers, gloves, and goggles) and collective protection equipment (e.g., agricultural tractors with sealed cabins) have been developed. In general, these approaches are intended to reduce the contact of farmers and agricultural machinery operators with the more toxic and stable compounds, an example of which is fenitrothion. In this study, fenitrothion was used as a marker to evaluate the protection afforded inside a sealed tractor cabin. To simulate the pesticide exposure, tests were performed using artificial cotton targets as passive adsorptive agents inside the cabin during the pesticide application. Samples were extracted according to the US Environmental Protection Agency (USEPA) procedure using ultrasonic extraction and as proposed by the Brazilian Standard for Solid Waste Classification (NBR 10004). The extracts were analyzed by high-performance liquid chromatography with diode array detection (HPLC-DAD). The chromatographic method was optimized using a factorial design. The combined results indicated that the best conditions were achieved using a mobile phase with a water/acetonitrile ratio of 35:65, a column temperature of 40 °C, and a flow rate of 1.0 mL/min, with a total analysis time of <10 min. The method was evaluated in the linear range of 0.50 to 2.01 mg/kg, with a determination coefficient of 0.9886. The precision was evaluated on different days and the relative standard deviations were between 0.17 and 3.41 %. In relation to the accuracy, recovery values of 95 to 104 % were obtained. The detection and quantification limits were 0.18 and 0.50 mg/kg, respectively. None of the target cottons showed concentrations of fenitrothion above the limit of detection of 0.18 mg/kg.
[Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar/análise
Monitoramento Ambiental/métodos
Fenitrotion/análise
Veículos Automotores/normas
Exposição Ocupacional/prevenção & controle
Praguicidas/análise
[Mh] Termos MeSH secundário: Agricultura/métodos
Agricultura/normas
Brasil
Cromatografia Líquida de Alta Pressão/métodos
Modelos Teóricos
Equipamento de Proteção Individual/normas
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Occupational); 0 (Pesticides); W8M4X3Y7ZY (Fenitrothion)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161113
[St] Status:MEDLINE


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[PMID]:27363049
[Au] Autor:Mikhail MW; Abd El-Halim AS; Soliman MI
[Ti] Título:EFFICACY OF THREE INSECTICIDES ON RAT FLEA (XENOPSYLLA CHEOPIS) INFESTING RODENTS IN GIZA GOVERNORATE, EGYPT.
[So] Source:J Egypt Soc Parasitol;46(1):131-4, 2016 Apr.
[Is] ISSN:1110-0583
[Cp] País de publicação:Egypt
[La] Idioma:eng
[Ab] Resumo:The extensive use of insecticides in public health and agriculture sectors is the main reason for development of resistance in fleas associated in domestic rodents. The present work was planned to investigate the insecticidal efficacy of Lambda-cyhalothrin, Chlorpyrifos and Fenitrothion against rat flea (Xenopsylla cheopis) infesting rodent species in Giza Governorate, Egypt. The lethal concentration Lc50 and Lc90 of population percent were obtained from the established regression log concentrate-response lines. Data indicated that the values of lethal concentration (Lc50) were 0.293, 1.725 & 2.328% for Lambda-cyhalothrin, chlorpyrifos and Fenitrothion, respectively. The values of lethal concentration (Lc90) were 0.467, 2.839 & 5.197% for Lambda-cyhalothrin, chlorpyrifos and Fenitrothion, respectively.
[Mh] Termos MeSH primário: Clorpirifos/farmacologia
Fenitrotion/farmacologia
Infestações por Pulgas/veterinária
Nitrilos/farmacologia
Piretrinas/farmacologia
Doenças dos Roedores/parasitologia
Xenopsylla/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Clorpirifos/administração & dosagem
Egito
Fenitrotion/administração & dosagem
Infestações por Pulgas/tratamento farmacológico
Resistência a Inseticidas
Inseticidas/farmacologia
Nitrilos/administração & dosagem
Piretrinas/administração & dosagem
Ratos
Doenças dos Roedores/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Nitriles); 0 (Pyrethrins); JCS58I644W (Chlorpyrifos); V0V73PEB8M (cyhalothrin); W8M4X3Y7ZY (Fenitrothion)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160701
[Lr] Data última revisão:
160701
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160702
[St] Status:MEDLINE


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[PMID]:27297964
[Au] Autor:Lapointe JM; Snyder PA; Reagan WJ
[Ad] Endereço:a Drug Safety Research and Development, Pfizer Global Research and Development , Groton , CT , USA.
[Ti] Título:Evaluation of urinary corticosterone as a biomarker of stress in rats using fenitrothion as a chemical stressor.
[So] Source:J Immunotoxicol;13(3):386-92, 2016 May.
[Is] ISSN:1547-6901
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Regulatory guidelines for pharmaceutical toxicity studies recommend using one dose near the maximum tolerated. At that level significant toxicities may occur, leading to systemic stress and secondary immune suppression which can be difficult to differentiate from a primary drug effect. Therefore, there is a need for a biomarker of stress applicable to toxicity studies. This study evaluated urinary corticosterone as a biomarker, using as a pharmacologic stressor fenitrothion, which was previously shown not to cause primary immune suppression. Rats were administered fenitrothion orally at 20 and 30 mg/kg daily for 2 or 8 days, with matched vehicle controls (n = 6/group). Urine was collected for 6 and 24 h, before treatment and on Day 2 and Day 8. Urine was assayed for corticosterone, separately for the first 6 h of collection and for the whole 24 h sample. Animals were euthanized on Day 3 or Day 9 and lymphoid tissue samples were collected, weighed and examined histologically. Treated rats showed neurologic signs following treatment. Findings also included time- and dose-dependent decreases in body weight and spleen and thymus weight decreases supra-proportional to body weight on Day 9. Histologic changes were mild at a dose of 20 mg/kg, but significant at 30 mg/kg, consisting of lymphocytolysis at Day 3 and lymphoid depletion at Day 9. Urine corticosterone levels were increased on Day 2 and Day 8, in the 6-h samples, but not the 24-h ones, at both dose levels. Based on the results, urine corticosterone appears to be a sensitive biomarker of systemic stress caused by fenitrothion. Other chemical stressors should be evaluated in a similar manner in order to fully validate urine corticosterone measurement as a stress biomarker.
[Mh] Termos MeSH primário: Sistemas de Notificação de Reações Adversas a Medicamentos
Biomarcadores/urina
Corticosterona/urina
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/diagnóstico
Fenitrotion/efeitos adversos
Imunossupressores/efeitos adversos
Estresse Fisiológico/fisiologia
[Mh] Termos MeSH secundário: Animais
Peso Corporal
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/metabolismo
Fenitrotion/administração & dosagem
Imunossupressores/administração & dosagem
Masculino
Ratos
Ratos Sprague-Dawley
Baço/efeitos dos fármacos
Baço/patologia
Timo/efeitos dos fármacos
Timo/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Immunosuppressive Agents); W8M4X3Y7ZY (Fenitrothion); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160615
[St] Status:MEDLINE
[do] DOI:10.3109/1547691X.2015.1106623


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[PMID]:27155482
[Au] Autor:Dhungana SK; Kim ID; Kwak HS; Shin DH
[Ad] Endereço:School of Applied Biosciences, Kyungpook National University, Daegu 702-701, Republic of Korea.
[Ti] Título:Unraveling the effect of structurally different classes of insecticide on germination and early plant growth of soybean [Glycine max (L.) Merr].
[So] Source:Pestic Biochem Physiol;130:39-43, 2016 Jun.
[Is] ISSN:1095-9939
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although a considerable number of studies about the effect of different insecticides on plant physiology and metabolism have been carried out, research work about the comparative action of structurally different classes of insecticide on physiological and biochemical properties of soybean seed germination and early growth has not been found. The objective of this study was to investigate the effect of different classes of insecticides on soybean seed germination and early plant growth. Soybean seeds of Bosuk cultivar were soaked for 24h in distilled water or recommended dose (2mLL(-1), 1mLL(-1), 0.5gL(-1), and 0.5gL(-1) water for insecticides Mepthion, Myungtaja, Actara, and Stonate, respectively) of pesticide solutions of four structurally different classes of insecticides - Mepthion (fenitrothion; organophosphate), Myungtaja (etofenprox; pyrethroid), Actara (thiamethoxam; neonicotinoid), and Stonate (lambda-cyhalothrin cum thiamethoxam; pyrethroid cum neonicotinoid) - which are used for controlling stink bugs in soybean crop. Insecticides containing thiamethoxam and lamda-cyhalothrin cum thiamethoxam showed positive effects on seedling biomass and content of polyphenol and flavonoid, however fenitrothion insecticide reduced the seed germination, seed and seedling vigor, and polyphenol and flavonoid contents in soybean. Results of this study reveal that different classes of insecticide have differential influence on physiologic and metabolic actions like germination, early growth, and antioxidant activities of soybean and this implies that yield and nutrient content also might be affected with the application of different types of insecticide.
[Mh] Termos MeSH primário: Germinação/efeitos dos fármacos
Inseticidas/farmacologia
Plântulas/efeitos dos fármacos
Feijão de Soja/efeitos dos fármacos
[Mh] Termos MeSH secundário: Fenitrotion/farmacologia
Neonicotinoides
Nitrilos/farmacologia
Nitrocompostos/farmacologia
Oxazinas/farmacologia
Piretrinas/farmacologia
Plântulas/crescimento & desenvolvimento
Feijão de Soja/crescimento & desenvolvimento
Tiazóis/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Neonicotinoids); 0 (Nitriles); 0 (Nitro Compounds); 0 (Oxazines); 0 (Pyrethrins); 0 (Thiazoles); 0LD7P9153C (ethofenprox); 747IC8B487 (thiamethoxam); V0V73PEB8M (cyhalothrin); W8M4X3Y7ZY (Fenitrothion)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160508
[St] Status:MEDLINE


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[PMID]:27105555
[Au] Autor:Spaggiari D; Daali Y; Rudaz S
[Ad] Endereço:School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Boulevard d'Yvoy 20, 1211 Geneva 4, Switzerland. Electronic address: dany.spaggiari@unige.ch.
[Ti] Título:An extensive cocktail approach for rapid risk assessment of in vitro CYP450 direct reversible inhibition by xenobiotic exposure.
[So] Source:Toxicol Appl Pharmacol;302:41-51, 2016 Jul 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Acute exposure to environmental factors strongly affects the metabolic activity of cytochrome P450 (P450). As a consequence, the risk of interaction could be increased, modifying the clinical outcomes of a medication. Because toxic agents cannot be administered to humans for ethical reasons, in vitro approaches are therefore essential to evaluate their impact on P450 activities. In this work, an extensive cocktail mixture was developed and validated for in vitro P450 inhibition studies using human liver microsomes (HLM). The cocktail comprised eleven P450-specific probe substrates to simultaneously assess the activities of the following isoforms: 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 2J2 and subfamily 3A. The high selectivity and sensitivity of the developed UHPLC-MS/MS method were critical for the success of this methodology, whose main advantages are: (i) the use of eleven probe substrates with minimized interactions, (ii) a low HLM concentration, (iii) fast incubation (5min) and (iv) the use of metabolic ratios as microsomal P450 activities markers. This cocktail approach was successfully validated by comparing the obtained IC50 values for model inhibitors with those generated with the conventional single probe methods. Accordingly, reliable inhibition values could be generated 10-fold faster using a 10-fold smaller amount of HLM compared to individual assays. This approach was applied to assess the P450 inhibition potential of widespread insecticides, namely, chlorpyrifos, fenitrothion, methylparathion and profenofos. In all cases, P450 2B6 was the most affected with IC50 values in the nanomolar range. For the first time, mixtures of these four insecticides incubated at low concentrations showed a cumulative inhibitory in vitro effect on P450 2B6.
[Mh] Termos MeSH primário: Inibidores das Enzimas do Citocromo P-450/toxicidade
Sistema Enzimático do Citocromo P-450/metabolismo
Inseticidas/toxicidade
Xenobióticos/toxicidade
[Mh] Termos MeSH secundário: Clorpirifos/toxicidade
Interações Medicamentosas
Fenitrotion/toxicidade
Seres Humanos
Metil Paration/toxicidade
Microssomos Hepáticos/metabolismo
Organotiofosfatos/toxicidade
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytochrome P-450 Enzyme Inhibitors); 0 (Insecticides); 0 (Organothiophosphates); 0 (Xenobiotics); 41BCL2O91D (Methyl Parathion); 7J04O7BS4W (profenofos); 9035-51-2 (Cytochrome P-450 Enzyme System); JCS58I644W (Chlorpyrifos); W8M4X3Y7ZY (Fenitrothion)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170530
[Lr] Data última revisão:
170530
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160424
[St] Status:MEDLINE


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[PMID]:26688262
[Au] Autor:Kaonga CC; Takeda K; Sakugawa H
[Ad] Endereço:Graduate School of Biosphere Science, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima, 739-8521, Japan.
[Ti] Título:Concentration and degradation of alternative biocides and an insecticide in surface waters and their major sinks in a semi-enclosed sea, Japan.
[So] Source:Chemosphere;145:256-64, 2016 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A mass distribution model was used to predict the fate of Diuron, Irgarol 1051 and Fenitrothion in Seto Inland Sea which is located in western Japan. This was done by using concentration, degradation, and literature data. Diuron and Irgarol 1051 in Seto Inland Sea are mainly derived from antifouling paints used for ships and boats. On the other hand Fenitrothion exclusively comes from land via rivers and atmospheric deposition. The total inputs/yr to Seto Inland Sea were found to be 104 tons, 7.65 tons and 5.14 tons for Diuron, Irgarol 1051 and Fenitrothion, respectively. The pesticide residence times were 0.26 yr, 0.36 yr and 0.17 yr for Diuron, Irgarol 1051 and Fenitrothion, respectively. Photodegradation was faster than biodegradation. In seawater, the half-life ranges were 37.9-57.3 d for photodegradation. In the same seawater the half-life ranges were 1650-2394 d for biodegradation. Photodegradation is effective in surface water (0-5 m depth) while biodegradation occurs throughout the entire water column. Plankton and fishes accumulate these pesticides significantly. The pesticides are deposited (sorbed and buried with) sediments (between 74 and 87% of total input amounts). The open ocean is an important sink accounting for between 8 and 17% of the total pesticide input amounts while photo- and biodegradation accounts for a small percentage.
[Mh] Termos MeSH primário: Diurona/análise
Fenitrotion/análise
Praguicidas/análise
Água do Mar/análise
Triazinas/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Monitoramento Ambiental
Meia-Vida
Herbicidas/análise
Inseticidas/análise
Japão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Herbicides); 0 (Insecticides); 0 (Pesticides); 0 (Triazines); 0 (Water Pollutants, Chemical); 28159-98-0 (irgarol 1051); 9I3SDS92WY (Diuron); W8M4X3Y7ZY (Fenitrothion)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160121
[Lr] Data última revisão:
160121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151222
[St] Status:MEDLINE


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[PMID]:26549836
[Au] Autor:Sato H; Ito Y; Ueyama J; Kano Y; Arakawa T; Gotoh M; Kondo T; Sugiura Y; Saito I; Shibata E; Kamijima M
[Ad] Endereço:Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences.
[Ti] Título:Effects of Paraoxonase 1 gene polymorphisms on organophosphate insecticide metabolism in Japanese pest control workers.
[So] Source:J Occup Health;58(1):56-65, 2016.
[Is] ISSN:1348-9585
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Paraoxonase 1 (PON1) in serum detoxifies organophosphate (OP) insecticides by hydrolysis. The present cross-sectional study aimed to clarify the relationship between PON1 single nucleotide polymorphisms (SNPs) and enzyme activities or OP metabolite concentrations in urine of workers occupationally exposed to low-level OPs. METHODS: Among 283 workers in 10 pest control companies located in central Japan who underwent checkups, 230 subjects (male 199, female 31, average age 38.9 ± 11.1 years old) participated in the study. Q192R and L55M polymorphisms were determined by TaqMan assay. PON1 activity was measured using fenitrothion (FNT) oxon, chlorpyrifos-methyl (CPM) oxon, chlorpyrifos (CP) oxon, and phenyl acetate as substrates. Urinary OP metabolite concentrations were measured with gas chromatography-mass spectrometry. RESULTS: The maximum differences in enzyme activities between individuals were 64.6-, 6.3-, 7.7-, and 2.0-fold for FNT oxonase, CPM oxonase, CP oxonase, and arylesterase (ARE), respectively. The activities of CPM oxonase and ARE in workers having the RR genotype were 53.5% and 18.2% lower than in those with the QQ genotype, respectively. CP oxonase activity was 15.0% lower in those having the M allele (LM + MM compared with LL). Urinary metabolite concentrations were not associated with PON1 polymorphisms, but negative associations were observed between the concentrations and activities of FNT oxonase and ARE. CONCLUSIONS: While PON1 SNPs can explain differences in catalytic activities toward some OPs, differences in urinary concentrations of OP metabolites are not attributable to PON1 SNPs but instead are attributable to its serum activities. Its serum activities might be more sensitive biomarkers for estimation of individual susceptibility to OP toxicities.
[Mh] Termos MeSH primário: Arildialquilfosfatase/genética
Inseticidas/urina
Organofosfatos/urina
Controle de Pragas
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Acetatos/metabolismo
Adulto
Alelos
Hidrolases de Éster Carboxílico/metabolismo
Clorpirifos/análogos & derivados
Clorpirifos/metabolismo
Estudos Transversais
Feminino
Fenitrotion/metabolismo
Cromatografia Gasosa-Espectrometria de Massas
Genótipo
Seres Humanos
Japão
Masculino
Meia-Idade
Exposição Ocupacional
Fenóis/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetates); 0 (Insecticides); 0 (Organophosphates); 0 (Phenols); 355G9R500Y (phenyl acetate); 5598-15-2 (O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate); EC 3.1.1.- (Carboxylic Ester Hydrolases); EC 3.1.1.2 (arylesterase); EC 3.1.8.1 (Aryldialkylphosphatase); EC 3.1.8.1 (PON1 protein, human); JCS58I644W (Chlorpyrifos); O49S38267J (chlorpyrifos-methyl); W8M4X3Y7ZY (Fenitrothion)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151110
[St] Status:MEDLINE
[do] DOI:10.1539/joh.15-0175-OA



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