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[PMID]:28394886
[Au] Autor:Grigoraki L; Pipini D; Labbé P; Chaskopoulou A; Weill M; Vontas J
[Ad] Endereço:Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Greece.
[Ti] Título:Carboxylesterase gene amplifications associated with insecticide resistance in Aedes albopictus: Geographical distribution and evolutionary origin.
[So] Source:PLoS Negl Trop Dis;11(4):e0005533, 2017 Apr.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Aedes albopictus is one of the most invasive human disease vectors. Its control has been largely based on insecticides, such as the larvicide temephos. Temephos resistance has been associated with the up-regulation, through gene amplification, of two carboxylesterase (CCE) genes closely linked on the genome, capable of sequestering and metabolizing temephos oxon, the activated form of temephos. PRINCIPAL FINDINGS: Here, we investigated the occurrence, geographical distribution and origin of the CCE amplicon in Ae. albopictus populations from several geographical regions worldwide. The haplotypic diversity at the CCEae3a locus revealed high polymorphism, while phylogenetic analysis showed an absence of correlation between haplotype similarity and geographic origin. Two types of esterase amplifications were found, in two locations only (Athens and Florida): one, previously described, results in the amplification of both CCEae3a and CCEae6a; the second is being described for the first time and results in the amplification of CCEae3a only. The two amplification events are independent, as confirmed by sequence analysis. All individuals from Athens and Florida carrying the CCEae3a-CCEae6a co-amplicon share a common haplotype, indicating a single amplification event, which spread between the two countries. SIGNIFICANCE: The importance of passive transportation of disease vectors, including individuals carrying resistance mechanisms, is discussed in the light of efficient and sustainable vector control strategies.
[Mh] Termos MeSH primário: Aedes/genética
Carboxilesterase/genética
Resistência a Inseticidas/genética
Inseticidas
Temefós
[Mh] Termos MeSH secundário: Aedes/enzimologia
Animais
Amplificação de Genes
Perfilação da Expressão Gênica
Genes de Insetos
Insetos Vetores/genética
Larva
Controle de Mosquitos
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); EC 3.1.1.1 (Carboxylesterase); ONP3ME32DL (Temefos)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005533


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[PMID]:28301568
[Au] Autor:Dos Santos Dias L; Macoris ML; Andrighetti MT; Otrera VC; Dias AD; Bauzer LG; Rodovalho CM; Martins AJ; Lima JB
[Ad] Endereço:Laboratório de Fisiologia e Controle de Artrópodes Vetores, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ-Brasil.
[Ti] Título:Toxicity of spinosad to temephos-resistant Aedes aegypti populations in Brazil.
[So] Source:PLoS One;12(3):e0173689, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The mosquito Aedes aegypti is the primary vector of different arboviruses and represents a major public health problem. Several Brazilian populations of Ae. aegypti have developed resistance to temephos, the most used organophosphate larvicide. New tools which are less harmful to the environment and safer for humans are becoming increasingly important to control this insect vector. Spinosad, an aerobic fermentation product of a soil actinobacteria, has a favorable environmental profile. It presents selective insecticide properties, a mechanism of action that differs from those of many synthetic chemical insecticides. The toxicity of spinosad and temephos to Aedes aegypti populations from Brazil, which were previously exposed to temephos, were investigated in this study. Larval susceptibility (LC50) to temephos varied from 3µg/L for Rockefeller up to 260 µg/L for Santana do Ipanema field derived population. Larval susceptibility (LC50) to spinosad varied from 23µg/L for Rockefeller up to 93µg/L for Marilia field derived population. In addition, a semi-field trial was performed to evaluate spinosad (NatularTM DT) initial efficacy and persistence toward four field-derived lineages and the Rockefeller lineage, used as an internal control. Spinosad was tested at 0.5mg active ingredient/L in 200L capacity water tanks. Mortality was recorded each 24 hours after exposition and tanks were further recolonized once per week with mortality being recorded daily for eight weeks. Spinosad provided a level equal or superior to 80% mortality during a seven to eight week evaluation period. The assessed populations did not present cross-resistance between spinosad and temephos in laboratory conditions. It demonstrates that spinosad may be a promising larvicide for the control of Ae. aegypti, especially for populations in which resistance to temephos has been detected.
[Mh] Termos MeSH primário: Aedes/efeitos dos fármacos
Inseticidas/farmacologia
Macrolídeos/toxicidade
Temefós/farmacologia
[Mh] Termos MeSH secundário: Aedes/crescimento & desenvolvimento
Animais
Brasil
Combinação de Medicamentos
Seres Humanos
Larva/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Insecticides); 0 (Macrolides); ONP3ME32DL (Temefos); XPA88EAP6V (spinosad)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173689


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[PMID]:28254583
[Au] Autor:Bharati M; Saha D
[Ad] Endereço:Insect Biochemistry and Molecular Biology Laboratory, Department of Zoology, University of North Bengal, P.O. North Bengal University, Siliguri 734013, District-Darjeeling, West Bengal, India.
[Ti] Título:Insecticide susceptibility status and major detoxifying enzymes' activity in Aedes albopictus (Skuse), vector of dengue and chikungunya in Northern part of West Bengal, India.
[So] Source:Acta Trop;170:112-119, 2017 Jun.
[Is] ISSN:1873-6254
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Mosquitoes belonging to Aedes genus, Aedes aegypti and Aedes albopictus transmit many globally important arboviruses including Dengue (DENV) and Chikungunya (CHIKV). Vector control with the use of insecticide remains the suitable method of choice to stop the transmission of these diseases. However, vector control throughout the world is failing to achieve its target results because of the worldwide development of insecticide resistance in mosquitoes. To assess the insecticide susceptibility status of Aedes albopictus from northern part of West Bengal, the susceptibility of eight different Aedes albopictus populations were tested against a commonly used larvicide (temephos) and some adulticides (malathion, deltamethrin and lambda cyhalothrin) along with the major insecticide detoxifying enzymes' activity in them. Through this study, it was revealed that most of the populations were found susceptible to temephos except Nagrakata (NGK) and Siliguri (SLG), which showed both a higher resistance ratio (RR ) and a lower susceptibility, thereby reflecting the development of resistance against temephos in them. However, all tested adulticides caused 100% mortality in all the population implying their potency in control of this mosquito in this region of India. Through the study of carboxylesterase activity, it was revealed that the NGK population showed a 9.6 fold higher level of activity than susceptible population. The same population also showed a lower level of susceptibility and a higher resistance ratio (RR ), indicating a clear correlation between susceptibility to temephos and carboxylesterase enzymes' activity in this population. This preliminary data reflects that the NGK population is showing a trend towards resistance development and with time, there is possibility that this resistance phenomenon will spread to other populations. With the recurrence of dengue and chikungunya, this data on insecticide susceptibility status of Aedes albopictus could help the authorities engaged in vector control programmes to formulate effective measures against this mosquito in this region.
[Mh] Termos MeSH primário: Aedes/enzimologia
Febre de Chikungunya/transmissão
Dengue/transmissão
Insetos Vetores/enzimologia
Resistência a Inseticidas/efeitos dos fármacos
Inseticidas/farmacologia
[Mh] Termos MeSH secundário: Animais
Suscetibilidade a Doenças
Seres Humanos
Índia/epidemiologia
Larva/efeitos dos fármacos
Malation/farmacologia
Nitrilos/farmacologia
Piretrinas/farmacologia
Temefós/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Nitriles); 0 (Pyrethrins); 2JTS8R821G (decamethrin); ONP3ME32DL (Temefos); U5N7SU872W (Malathion); V0V73PEB8M (cyhalothrin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE


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[PMID]:28213320
[Au] Autor:Vasantha-Srinivasan P; Senthil-Nathan S; Ponsankar A; Thanigaivel A; Edwin ES; Selin-Rani S; Chellappandian M; Pradeepa V; Lija-Escaline J; Kalaivani K; Hunter WB; Duraipandiyan V; Al-Dhabi NA
[Ad] Endereço:óDivision of Biopesticides and Environmental Toxicology, Sri Paramakalyani Centre for Excellence in Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi, 627 412 Tirunelveli, Tamil Nadu, India.
[Ti] Título:Comparative analysis of mosquito (Diptera: Culicidae: Aedes aegypti Liston) responses to the insecticide Temephos and plant derived essential oil derived from Piper betle L.
[So] Source:Ecotoxicol Environ Saf;139:439-446, 2017 May.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Resistance to treatments with Temephos or plant derived oil, Pb-CVO, between a field collected Wild Strain (WS) and a susceptible Laboratory Strain (LS) of Ae. aegypti were measured. The Temephos (0.1mg/L) showed the greatest percentage of mosquito mortality compared to Pb-CVO (1.5mg/L) in LS Ae. aegypti. However, WS Ae. aegypti was not significantly affected by Temephos (0.1mg/L) treatment compare to the Pb-CVO (1.5mg/L). However, both strains (LS and WS) when treated with Pb-CVO (1.5mg/L) displayed steady larval mortality rate across all instars. The LC of Temephos was 0.027mg in LS, but increased in WS to 0.081mg/L. The LC of Pb-CVO treatment was observed at concentrations of 0.72 and 0.64mg/L for LS and WS strains respectively. The enzyme level of α- and ß-carboxylesterase was reduced significantly in both mosquito strains treated with Pb-CVO. Whereas, there was a prominent deviation in the enzyme ratio observed between LS and WS treated with Temephos. The GST and CYP450 levels were upregulated in the LS, but decreased in WS, after treatment with Temephos. However, treatment with Pb-CVO caused both enzyme levels to increase significantly in both the strains. Visual observations of the midgut revealed cytotoxicity from sub-lethal concentrations of Temephos (0.04mg/L) and Pb-CVO (1.0mg/L) in both strains of Ae. aegypti compared to the control. The damage caused by Temephos was slightly less in WS compared to LS mosquito strains.
[Mh] Termos MeSH primário: Inseticidas
Óleos Voláteis
Temefós
[Mh] Termos MeSH secundário: Aedes/efeitos dos fármacos
Aedes/enzimologia
Aedes/crescimento & desenvolvimento
Animais
Resistência a Inseticidas
Larva/efeitos dos fármacos
Piper betle/efeitos dos fármacos
Óleos Vegetais
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Oils, Volatile); 0 (Plant Oils); ONP3ME32DL (Temefos)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170219
[St] Status:MEDLINE


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[PMID]:28187825
[Au] Autor:Sharifi M; Ghadamyari M; Gholivand K; Valmoozi AA; Sajedi RH
[Ad] Endereço:Department of Plant Protection, Faculty of Agricultural Sciences, University of Guilan, Rasht, Iran.
[Ti] Título:Characterization of acetylcholinesterase from elm left beetle, Xanthogaleruca luteola and QSAR of temephos derivatives against its activity.
[So] Source:Pestic Biochem Physiol;136:12-22, 2017 Mar.
[Is] ISSN:1095-9939
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Insect acetylcholinesterase (AChE) is the principal target for organophosphate (OP) and carbamate (CB) insecticides. In this research, an AChE from third instar larvae of elm left beetle, Xanthogaleruca luteola was purified by affinity chromatography. The enzyme was purified 75.29-fold with a total yield of 8.51%. As shown on denaturing SDS-PAGE, the molecular mass of purified AChE was 70kDa. The enzyme demonstrated maximum activity at pH7 and 35°C. Furthermore, a series of temephos (Tem) derivatives with the general structure of P(O)XP(O) (1-44) were prepared, synthesized and characterized by P, C, H NMR and FT-IR spectral techniques. The toxicity of 36 new Tem derivatives was screened on the third instar larvae and the compound compound 1,2 cyclohexane-N,N'-bis(N,N'-piperidine phosphoramidate) exhibited the highest insecticidal potential. The method of kinetic analysis is applied in order to obtain the maximum velocity (V ), the Michaelis constant (K ) and the parameters characterizing the inhibition type for inhibitors with >75% mortality in preliminary bioassay. The inhibition mechanism was mixed and inhibitory constant (K ) was calculated as 4.70µM min for this compound. Quantitative structure-activity relationship (QSAR) equations of these compounds indicated that the electron orbital energy has major effect on insecticidal properties.
[Mh] Termos MeSH primário: Acetilcolinesterase/metabolismo
Inibidores da Colinesterase/farmacologia
Coleópteros/enzimologia
Proteínas de Insetos/metabolismo
Inseticidas/farmacologia
Temefós/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/isolamento & purificação
Animais
Proteínas de Insetos/isolamento & purificação
Inseticidas/química
Larva/enzimologia
Relação Quantitativa Estrutura-Atividade
Temefós/análogos & derivados
Temefós/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholinesterase Inhibitors); 0 (Insect Proteins); 0 (Insecticides); EC 3.1.1.7 (Acetylcholinesterase); ONP3ME32DL (Temefos)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170212
[St] Status:MEDLINE


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[PMID]:28187780
[Au] Autor:Goindin D; Delannay C; Gelasse A; Ramdini C; Gaude T; Faucon F; David JP; Gustave J; Vega-Rua A; Fouque F
[Ad] Endereço:Laboratory of Medical Entomology, Unit Environment and Health, Pasteur Institute of Guadeloupe, 97183, Les Abymes, Guadeloupe. daniella.goindin@gmail.com.
[Ti] Título:Levels of insecticide resistance to deltamethrin, malathion, and temephos, and associated mechanisms in Aedes aegypti mosquitoes from the Guadeloupe and Saint Martin islands (French West Indies).
[So] Source:Infect Dis Poverty;6(1):38, 2017 Feb 10.
[Is] ISSN:2049-9957
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In the Guadeloupe and Saint Martin islands, Aedes aegypti mosquitoes are the only recognized vectors of dengue, chikungunya, and Zika viruses. For around 40 years, malathion was used as a mosquito adulticide and temephos as a larvicide. Since the European Union banned the use of these two insecticide molecules in the first decade of the 21st century, deltamethrin and Bacillus thuringiensis var. israelensis are the remaining adulticide and larvicide, respectively, used in Guadeloupe. In order to improve the management of vector control activities in Guadeloupe and Saint Martin, we investigated Ae. aegypti resistance to and mechanisms associated with deltamethrin, malathion, and temephos. METHODS: Ae. aegypti mosquitoes were collected from six different localities of Guadeloupe and Saint Martin. Larvae were used for malathion and temephos bioassays, and adult mosquitoes for deltamethrin bioassays, following World Health Organization recommendations. Knockdown resistance (Kdr) genotyping for V1016I and F1534C mutations, and expression levels of eight enzymes involved in detoxification mechanisms were examined in comparison with the susceptible reference Bora Bora strain. RESULTS: Resistance ratios (RR ) calculated for Ae. aegypti larvae showed high resistance levels to temephos (from 8.9 to 33.1-fold) and low resistance levels to malathion (from 1.7 to 4.4-fold). Adult females displayed moderate resistance levels to deltamethrin regarding the time necessary to affect 50% of individuals, varying from 8.0 to 28.1-fold. Molecular investigations on adult mosquitoes showed high resistant allele frequencies for V1016I and F1534C (from 85 to 96% and from 90 to 98%, respectively), as well as an overexpression of the glutathione S-transferase gene, GSTe2, the carboxylesterase CCEae3a, and the cytochrome genes 014614, CYP6BB2, CYP6M11, and CYP9J23. CONCLUSIONS: Ae. aegypti populations from Guadeloupe and Saint Martin exhibit multiple resistance to organophosphates (temephos and malathion), and pyrethroids (deltamethrin). The mechanisms associated with these resistance patterns show strong frequencies of F1534C and V1016I Kdr mutations, and an over-expression of CCEae3a, GSTe2, and four cytochrome P450 genes (014614, CYP9J23, CYP6M11, CYP6BB2). These results will form the baseline for a deeper understanding of the insecticide resistance levels and associated mechanisms of Ae. aegypti populations and will be used to improve vector control strategies in Guadeloupe and Saint Martin.
[Mh] Termos MeSH primário: Aedes/efeitos dos fármacos
Vetores de Doenças
Resistência a Inseticidas
Inseticidas/farmacologia
Malation/farmacologia
Nitrilos/farmacologia
Piretrinas/farmacologia
Temefós/farmacologia
[Mh] Termos MeSH secundário: Aedes/genética
Aedes/fisiologia
Animais
Bioensaio
Feminino
Perfilação da Expressão Gênica
Técnicas de Genotipagem
Larva/efeitos dos fármacos
Mutação de Sentido Incorreto
Índias Ocidentais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Nitriles); 0 (Pyrethrins); 2JTS8R821G (decamethrin); ONP3ME32DL (Temefos); U5N7SU872W (Malathion)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170221
[Lr] Data última revisão:
170221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170212
[St] Status:MEDLINE
[do] DOI:10.1186/s40249-017-0254-x


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[PMID]:28034767
[Au] Autor:Lakwo T; Garms R; Wamani J; Tukahebwa EM; Byamukama E; Onapa AW; Tukesiga E; Katamanywa J; Begumisa S; Habomugisha P; Oguttu D; Byamukama E; Richards F; Unnasch TR; Katabarwa M
[Ad] Endereço:Vector Control Division, Ministry of Health, P.O. Box 1661, Kampala, Uganda. Electronic address: tlakwo@gmail.com.
[Ti] Título:Interruption of the transmission of Onchocerca volvulus in the Kashoya-Kitomi focus, western Uganda by long-term ivermectin treatment and elimination of the vector Simulium neavei by larviciding.
[So] Source:Acta Trop;167:128-136, 2017 Mar.
[Is] ISSN:1873-6254
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Uganda is the only country in sub-Saharan Africa whose onchocerciasis elimination programme extensively uses vector control and biannual treatment with ivermectin. The purpose of this study was to assess the impact of combined strategies on interrupting onchocerciasis transmission in the Kashoya-Kitomi focus. Mass Drug Administration annually (13 years) followed by biannual treatments (6 years) and ground larviciding (36 cycles in 3 years) with temephos (Abate , EC500) against Simulium neavei were conducted. Routine fly catches were conducted for over seven years in six catching sites and freshwater crabs Potamonautes aloysiisabaudiae were examined for immature stages of Simulium neavei. Epidemiological assessments by skin snip were performed in 2004 and 2013. Collection of dry blood spots (DBS) from children <10 years for IgG4 antibodies analysis were done in 2010 and 2013. Treatment coverage with ivermectin improved with introduction of biannual treatment strategy. Microfilaria prevalence reduced from 85% in 1991 to 62% in 2004; and to only 0.5% in 2013. Crab infestation reduced from 59% in 2007 to 0% in 2013 following ground larviciding. Comparison of total fly catches before and after ground larviciding revealed a drop from 5334 flies in 2007 to 0 flies in 2009. Serological assays conducted among 1,362 children in 2010 revealed 11 positive cases (0.8%; 95% CI: 0.4%-1.2%). However, assessment conducted on 3246 children in 2013 revealed five positives, giving point prevalence of 0.15%; 95% CI: 0.02%-0.28%. Four of the five children subjected to O-150 PCR proved negative. The data show that transmission of onchocerciasis has been interrupted based on national and WHO Guidelines of 2012 and 2016, respectively.
[Mh] Termos MeSH primário: Antiparasitários/uso terapêutico
Controle de Insetos/métodos
Inseticidas
Oncocercose/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Criança
Seres Humanos
Insetos Vetores
Ivermectina/uso terapêutico
Microfilárias/efeitos dos fármacos
Onchocerca volvulus
Oncocercose/transmissão
Simuliidae/efeitos dos fármacos
Temefós
Uganda/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiparasitic Agents); 0 (Insecticides); 70288-86-7 (Ivermectin); ONP3ME32DL (Temefos)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161231
[St] Status:MEDLINE


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[PMID]:27212578
[Au] Autor:Nading AM
[Ad] Endereço:a Social Anthropology, School of Social and Political Science, University of Edinburgh , Edinburgh , Scotland , UK.
[Ti] Título:Local Biologies, Leaky Things, and the Chemical Infrastructure of Global Health.
[So] Source:Med Anthropol;36(2):141-156, 2017 Feb-Mar.
[Is] ISSN:1545-5882
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This article examines how two chemical substances are woven into the infrastructure of global health as well as into the social lives of health workers in urban Nicaragua. One chemical is temephos, an organophosphate used to control mosquitoes. The other is chlorine-based products, which are used to disinfect surfaces and water. While global health projects tend to treat these substances as stable objects, there are three ways in which they might be understood as leaky things, implicated in fluid social interactions. First, global health chemicals are tracked through rigid accounting, but because of numerical leakages, they become vehicles for fashioning new forms of concern. Second, chemicals leak structurally: They can be dissolved and reproduced at a molecular level, although that dissolution is never absolute, and that reproduction is not everywhere the same. Third, chemicals leak in a sensory fashion. Sensory interactions with chemicals produce an entanglement of knowledge about bodies and environments.
[Mh] Termos MeSH primário: Dengue
Exposição Ambiental
Saúde Global
Inseticidas
Temefós
[Mh] Termos MeSH secundário: Antropologia Médica
Cloro
Dengue/etnologia
Dengue/prevenção & controle
Dengue/transmissão
Desinfetantes
Seres Humanos
Nicarágua/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Disinfectants); 0 (Insecticides); 4R7X1O2820 (Chlorine); ONP3ME32DL (Temefos)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160524
[St] Status:MEDLINE
[do] DOI:10.1080/01459740.2016.1186672


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[PMID]:27627758
[Au] Autor:Setha T; Chantha N; Benjamin S; Socheat D
[Ad] Endereço:National Center for Parasitology, Entomology and Malaria Control, Ministry of Health, Phnom Penh, Cambodia.
[Ti] Título:Bacterial Larvicide, Bacillus thuringiensis israelensis Strain AM 65-52 Water Dispersible Granule Formulation Impacts Both Dengue Vector, Aedes aegypti (L.) Population Density and Disease Transmission in Cambodia.
[So] Source:PLoS Negl Trop Dis;10(9):e0004973, 2016 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A multi-phased study was conducted in Cambodia from 2005-2011 to measure the impact of larviciding with the bacterial larvicide, Bacillus thuringiensis israelensis (Bti), a water dispersible granule (WG) formulation on the vector, Aedes aegypti (L.) and the epidemiology. In our studies, all in-use containers were treated at 8 g/1000 L, including smaller containers and animal feeders which were found to contribute 23% of Ae aegypti pupae. The treated waters were subjected to routine water exchange activities. Pupal production was suppressed by an average 91% for 8 weeks. Pupal numbers continued to remain significantly lower than the untreated commune (UTC) for 13 weeks post treatment in the peak dengue vector season (p<0.05). Suppression of pupal production was supported by very low adult numbers in the treated commune. An average 70% of the household harbored 0-5 Ae aegypti mosquitoes per home for 8 weeks post treatment, but in the same period of time >50% of the household in the UTC harbored ≥11 mosquitoes per home. The adult population continued to remain at significantly much lower numbers in the Bti treated commune than in the UTC for 10-12 weeks post treatment (p<0.05). In 2011, a pilot operational program was evaluated in Kandal Province, a temephos resistant site. It was concluded that 2 cycles of Bti treatment in the 6 months monsoon season with complete coverage of the target districts achieved an overall dengue case reduction of 48% in the 6 treated districts compared to the previous year, 2010. Five untreated districts in the same province had an overwhelming increase of 352% of dengue cases during the same period of time. The larvicide efficacy, treatment of all in-use containers at the start of the monsoon season, together with treatment coverage of entire districts interrupted disease transmission in the temephos resistant province.
[Mh] Termos MeSH primário: Aedes/crescimento & desenvolvimento
Bacillus thuringiensis/fisiologia
Dengue/prevenção & controle
Controle de Mosquitos/métodos
[Mh] Termos MeSH secundário: Animais
Camboja
Resistência a Medicamentos
Ecossistema
Características da Família
Seres Humanos
Insetos Vetores
Inseticidas
Densidade Demográfica
Pupa/crescimento & desenvolvimento
Estações do Ano
Inquéritos e Questionários
Temefós
Microbiologia da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); ONP3ME32DL (Temefos)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170616
[Lr] Data última revisão:
170616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160915
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0004973


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Fotocópia
Valle, Denise
PubMed Central Texto completo
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[PMID]:27419140
[Au] Autor:Bellinato DF; Viana-Medeiros PF; Araújo SC; Martins AJ; Lima JB; Valle D
[Ad] Endereço:Laboratório de Biologia Molecular de Flavivírus, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.
[Ti] Título:Resistance Status to the Insecticides Temephos, Deltamethrin, and Diflubenzuron in Brazilian Aedes aegypti Populations.
[So] Source:Biomed Res Int;2016:8603263, 2016.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Insecticides are still largely applied in public health to control disease vectors. In Brazil, organophosphates (OP) and pyrethroids (PY) are used against Aedes aegypti for years. Since 2009 Insect Growth Regulators (IGR) are also employed in the control of larvae. We quantified resistance to temephos (OP), deltamethrin (PY), and diflubenzuron (IGR) of A. aegypti samples from 12 municipalities distributed throughout the country, collected between 2010 and 2012. High levels of resistance to neurotoxic insecticides were detected in almost all populations: RR95 to temephos varied between 4.0 and 27.1; the lowest RR95 to deltamethrin was 13.1, and values higher than 70.0 were found. In contrast, all samples were susceptible to diflubenzuron (RR95 < 2.3). Biochemical tests performed with larvae and adults discarded the participation of acetylcholinesterase, the OP target, and confirmed involvement of the detoxifying enzymes esterases, mixed function oxidases, and glutathione-S-transferases. The results obtained were discussed taking into account the public chemical control component and the increase in the domestic use of insecticides during dengue epidemic seasons in the evaluated municipalities.
[Mh] Termos MeSH primário: Aedes/efeitos dos fármacos
Aedes/fisiologia
Diflubenzuron/farmacologia
Resistência a Inseticidas/fisiologia
Inseticidas/farmacologia
Nitrilos/farmacologia
Piretrinas/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Aedes/metabolismo
Animais
Brasil
Vetores de Doenças
Feminino
Glutationa Transferase/metabolismo
Larva/efeitos dos fármacos
Larva/fisiologia
Masculino
Oxirredutases/metabolismo
Saúde Pública
Temefós/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Nitriles); 0 (Pyrethrins); 2JTS8R821G (decamethrin); EC 1.- (Oxidoreductases); EC 2.5.1.18 (Glutathione Transferase); EC 3.1.1.7 (Acetylcholinesterase); J76U6ZSI8D (Diflubenzuron); ONP3ME32DL (Temefos)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160716
[St] Status:MEDLINE
[do] DOI:10.1155/2016/8603263



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