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[PMID]:23328119
[Au] Autor:Seifert J
[Ad] Endereço:PEPS, University of Hawaii, Honolulu, HI 96822, USA. josef@hawaii.edu
[Ti] Título:Structural requirements of organophosphorus insecticides (OPI) to inhibit chicken yolk sac membrane kynurenine formamidase related to OPI teratogenesis.
[So] Source:Environ Toxicol Pharmacol;35(2):200-6, 2013 Mar.
[Is] ISSN:1872-7077
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This paper provides new information related to the mechanism of OPI (organophosphorus insecticides) teratogenesis. The COMFA (comparative molecular field analysis) and COMSIA (comparative molecular similarity indices analysis) suggest that the electrostatic and steric fields are the best predictors of OPI structural requirements to inhibit in ovo chicken embryo yolk sac membrane kynurenine formamidase, the proposed target for OPI teratogens. The dominant electrostatic interactions are localized at nitrogen-1, nitrogen-3, nitrogen of 2-amino substituent of the pyrimidinyl of pyrimidinyl phosphorothioates, and the oxygen of crotonamide carbonyl in crotonamide phosphates. Bulkiness of the substituents at carbon-2 and carbon-6 of the pyrimidinyls and/or N-substituents and carbon-3 substituents of crotonamides are the steric structural components that contribute to superiority of those OPI as in ovo inhibitors of kynurenine formamidase.
[Mh] Termos MeSH primário: Arilformamidase/antagonistas & inibidores
Inseticidas/química
Inseticidas/toxicidade
Compostos Organofosforados/química
Compostos Organofosforados/toxicidade
Relação Quantitativa Estrutura-Atividade
Teratogênios/toxicidade
Saco Vitelino/enzimologia
[Mh] Termos MeSH secundário: Animais
Embrião de Galinha
Inibidores Enzimáticos/química
Inibidores Enzimáticos/toxicidade
Leptofós/química
Leptofós/toxicidade
Modelos Moleculares
Paration/química
Paration/toxicidade
Eletricidade Estática
Teratogênios/química
Saco Vitelino/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Insecticides); 0 (Organophosphorus Compounds); 0 (Teratogens); 61G466064D (Parathion); C45E8FUG3Z (Leptophos); EC 3.5.1.9 (Arylformamidase)
[Em] Mês de entrada:1309
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130119
[St] Status:MEDLINE


  2 / 87 MEDLINE  
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[PMID]:21152278
[Au] Autor:Jun D; Musilova L; Pohanka M; Jung YS; Bostik P; Kuca K
[Ad] Endereço:Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
[Ti] Título:Reactivation of human acetylcholinesterase and butyrylcholinesterase inhibited by leptophos-oxon with different oxime reactivators in vitro.
[So] Source:Int J Mol Sci;11(8):2856-63, 2010 Aug 03.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:We have evaluated in vitro the potency of 23 oximes to reactivate human erythrocyte acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BChE) inhibited by racemic leptophos-oxon (O-[4-bromo-2,5-dichlorophenyl]-O-methyl phenyl-phosphonate), a toxic metabolite of the pesticide leptophos. Compounds were assayed in concentrations of 10 and 100 µM. In case of leptophos-oxon inhibited AChE, the best reactivation potency was achieved with methoxime, trimedoxime, obidoxime and oxime K027. The most potent reactivators of inhibited BChE were K033, obidoxime, K117, bis-3-PA, K075, K074 and K127. The reactivation efficacy of tested oximes was lower in case of leptophos-oxon inhibited BChE.
[Mh] Termos MeSH primário: Acetilcolinesterase/química
Butirilcolinesterase/química
Leptofós/análogos & derivados
Oximas/química
Praguicidas/química
[Mh] Termos MeSH secundário: Eritrócitos/efeitos dos fármacos
Eritrócitos/enzimologia
Seres Humanos
Leptofós/química
Leptofós/farmacologia
Praguicidas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Oximes); 0 (Pesticides); 83S10ESQ22 (leptophos oxon); C45E8FUG3Z (Leptophos); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase)
[Em] Mês de entrada:1411
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101215
[St] Status:MEDLINE
[do] DOI:10.3390/ijms11082856


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[PMID]:12742374
[Au] Autor:Yen JH; Tsai CC; Wang YS
[Ad] Endereço:Department of Agricultural Chemistry, National Taiwan University, 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan. sonny@ccms.ntu.edu.tw
[Ti] Título:Separation and toxicity of enantiomers of organophosphorus insecticide leptophos.
[So] Source:Ecotoxicol Environ Saf;55(2):236-42, 2003 Jun.
[Is] ISSN:0147-6513
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Enantiomers of leptophos were separated by high-performance liquid chromatography with a Whelk-O1 column using 3% dichloromethane in n-hexane as mobile phase. Toxicity tests of leptophos enantiomers and racemate were performed with daphnia. Enzyme inhibition of leptohpos was carried out by using butyryl cholinesterase from horse serum and acetylcholinesterase from housefly heads. From the inhibition test of butyrylcholinesterase, the half-inhibitory concentrations, IC(50), of (+)-leptophos, (-)-leptophos, and (+/-)-leptophos were 0.241, 1.17, and 1.05 gmL(-1), respectively. No significant difference in IC(50) in (-)-leptophos and (+/-)- leptophos was found. However, the IC(50) of (+)-leptophos was significantly different from those of the others. In the inhibition test of acetylcholinesterase, the IC(50) values of (+)-leptophos, (-)-leptophos, and (+/-)-leptophos were 14.01, 24.32, and 13.22 gmL(-1), respectively. There was no significant difference in IC(50) in (+)-leptophos and (+/-)-leptophos, although the IC(50) of (-)-leptophos was significantly different from those of the others. From these results, leptophos-both enantiomers and racemate-seems to have higher neurotoxicity for mammals than for the target insects. In the toxicity test of daphnia, the half-lethal concentrations, LC(50), of (+)-leptophos, (-)-leptophos, and (+/-)-leptophos were 0.0387, 0.802, and 0.0409 gL(-1), respectively. There is no significant difference in LC(50) in (+)-leptophos and (+/-)-leptophos. The LC(50) of (-)-leptophos is significantly higher than those of the others. From these results, (-)-leptophos has lower toxicity to daphnia.
[Mh] Termos MeSH primário: Daphnia/fisiologia
Inseticidas/química
Inseticidas/toxicidade
Leptofós/química
Leptofós/toxicidade
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Algoritmos
Animais
Butirilcolinesterase/metabolismo
Cromatografia Líquida de Alta Pressão
Inseticidas/isolamento & purificação
Leptofós/isolamento & purificação
Dose Letal Mediana
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insecticides); C45E8FUG3Z (Leptophos); EC 3.1.1.7 (Acetylcholinesterase); EC 3.1.1.8 (Butyrylcholinesterase)
[Em] Mês de entrada:0309
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:030514
[St] Status:MEDLINE


  4 / 87 MEDLINE  
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[PMID]:12697382
[Au] Autor:Piao F; Yamauchi T; Ma N
[Ad] Endereço:Department of Public Health, School of Medicine, Mie University, 2-174 Edobashi, Tsu, Mie-Pref. 514-8507, Japan. piao-mie@doc.medic.mie-u.ac.jp
[Ti] Título:The effect of Calcicol as calcium tonic on delayed neurotoxicity induced by organophosphorus compounds.
[So] Source:Toxicol Lett;143(1):65-71, 2003 Jun 05.
[Is] ISSN:0378-4274
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:To examine whether delayed neuropathy is prevented or alleviated when Ca is administered to experimental animals before or after organophosphorus compounds (OPs) dosing, we observed the effects of Calcicol administration as a calcium tonic on delayed neurotoxicity by OPs in hens. The hens (n=28) were randomly divided into seven groups (four in each group). One group received glycerol formal as vehicle group, two groups received 30 mg/kg leptophos or 40 mg/kg triortho-cresyl phosphate (TOCP) (L group and T group), two groups received 2.4 mg/kg Ca(2+) (0.3 ml/kg Calcicol) 24 h before leptophos or TOCP administration, and the last two groups received 2.4 mg/kg Ca after leptophos or TOCP administration, respectively. Although delayed polyneuropathy induced by OPs could not be prevented completely by Calcicol, the clinical signs of organophosphorus-induced delayed neuropathy (OPIDN) in hens that received Calcicol soon before or after OPs administration were less severe than those in hens that received only OPs and there were significant differences in OPIDN score between groups (P<0.05). This shows that polyneuropathy and the recovery function of nerves and muscles suffering from polyneuropathy can be alleviated, as long as calcium tonic is administered before the clinical signs develop. This study offers hope of recovery to humans who are exposed to these OPs because of work, attempted suicide, accidental ingestion or other accidents, etc. Meanwhile, our results indicate further that there is a relationship between a decrease in Ca(2+) concentration in tissues and induction of delayed neuropathy.
[Mh] Termos MeSH primário: Gluconato de Cálcio/farmacologia
Cálcio/metabolismo
Galinhas/fisiologia
Síndromes Neurotóxicas/prevenção & controle
Compostos Organofosforados/antagonistas & inibidores
Compostos Organofosforados/toxicidade
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/efeitos dos fármacos
Peso Corporal/efeitos dos fármacos
Cálcio/sangue
Feminino
Marcha Atáxica/induzido quimicamente
Inseticidas/antagonistas & inibidores
Inseticidas/toxicidade
Leptofós/antagonistas & inibidores
Leptofós/toxicidade
Paralisia/induzido quimicamente
Tritolil Fosfatos/antagonistas & inibidores
Tritolil Fosfatos/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Organophosphorus Compounds); 0 (Tritolyl Phosphates); C45E8FUG3Z (Leptophos); SQE6VB453K (Calcium Gluconate); SY7Q814VUP (Calcium); X8II18JD0A (tri-o-cresyl phosphate)
[Em] Mês de entrada:0306
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:030417
[St] Status:MEDLINE


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[PMID]:12537969
[Au] Autor:Sachana M; Flaskos J; Alexaki E; Hargreaves AJ
[Ad] Endereço:Laboratory of Biochemistry and Toxicology, Faculty of Veterinary Medicine, Aristotelian University of Thessaloniki, 546 06 Thessaloniki, Greece.
[Ti] Título:Inhibition of neurite outgrowth in N2a cells by leptophos and carbaryl: effects on neurofilament heavy chain, GAP-43 and HSP-70.
[So] Source:Toxicol In Vitro;17(1):115-20, 2003 Feb.
[Is] ISSN:0887-2333
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The neurodegenerative properties of the organophosphate ester leptophos (LEP) and the carbamate ester carbaryl (CB), both of which can cause neuropathic effects in animals, were investigated in differentiating mouse N2a neuroblastoma cells. At a sublethal concentration of 3 microM, both LEP and CB were able to inhibit the outgrowth of axon-like processes from N2a cells after only 4 h of exposure. Extracts of cells exposed to LEP showed decreased cross-reactivities with monoclonal antibodies that recognise the neurofilament heavy chain (NFH) and the growth-associated protein GAP-43. However, they exhibited increased cross-reactivity with a monoclonal antibody that recognises the heat shock protein HSP-70. In contrast, no changes were noted in the levels of antibody binding in blots of extracts of cells exposed to CB. It is concluded that, although both LEP and CB inhibit the formation of axons in vitro, the early biochemical changes underlying the neurodegenerative effects of the two compounds are different.
[Mh] Termos MeSH primário: Axônios/efeitos dos fármacos
Carbaril/efeitos adversos
Inseticidas/efeitos adversos
Leptofós/efeitos adversos
Neuritos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anticorpos Monoclonais
Relação Dose-Resposta a Droga
Proteínas de Choque Térmico HSP70/análise
Camundongos
Sistema Nervoso/efeitos dos fármacos
Sistema Nervoso/patologia
Neuroblastoma/patologia
Células Tumorais Cultivadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (HSP70 Heat-Shock Proteins); 0 (Insecticides); C45E8FUG3Z (Leptophos); R890C8J3N1 (Carbaryl)
[Em] Mês de entrada:0307
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:030123
[St] Status:MEDLINE


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[PMID]:10509429
[Au] Autor:Abdelsalam EB
[Ad] Endereço:Department of Pathology, Faculty of Veterinary Science, University of Khartoum, Sudan.
[Ti] Título:Neurotoxic potential of six organophosphorus compounds in adult hens.
[So] Source:Vet Hum Toxicol;41(5):290-2, 1999 Oct.
[Is] ISSN:0145-6296
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The neurotoxic potential of trichlorfon, diazinon, phosmet, dichlorvos, phosphamidon and coumaphos was evaluated for their ability to inhibit brain neurotoxic esterase (NTE) activity in adult hens. Leptophos was used as a reference neurotoxic agent. All compounds were administered at high single oral doses and the NTE and acetylcholinesterase (AchE) activities were measured at 24 h and 6 w later. With the exception of leptophos, all compounds produced severe cholinergic signs associated with > 80% inhibition of brain AchE at 24 h. On the other hand, brain NTE activity was 86% inhibited by leptophos and to lesser extents by trichlorfon (76%), phosphamidon (74%), coumaphos (70%) and dichlorvos (70%). However, none of the latter compounds produced clinical delayed neurotoxicity as was observed with leptophos. It was concluded that trichlorfon, phosphamidon, coumaphos and dichlorvos are potentially neurotoxic because of their ability to inhibit brain NTE activity, but the extent of inhibition required for development of clinical delayed neurotoxicity (> 80%) is not likely to occur with any of these compounds due to their severe cholinergic activity.
[Mh] Termos MeSH primário: Encéfalo/efeitos dos fármacos
Encéfalo/enzimologia
Esterases/metabolismo
Doenças do Sistema Nervoso/induzido quimicamente
Compostos Organofosforados/toxicidade
[Mh] Termos MeSH secundário: Animais
Galinhas
Cumafos/toxicidade
Diazinon/toxicidade
Diclorvós/toxicidade
Feminino
Leptofós/toxicidade
Fosmet/toxicidade
Fosfamidona/toxicidade
Triclorfon/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organophosphorus Compounds); 13171-21-6 (Phosphamidon); 7U370BPS14 (Dichlorvos); C45E8FUG3Z (Leptophos); DBF2DG4G2K (Trichlorfon); EC 3.1.- (Esterases); L08SZ5Z5JC (Coumaphos); VN04LI540Y (Phosmet); YUS1M1Q929 (Diazinon)
[Em] Mês de entrada:9911
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:991006
[St] Status:MEDLINE


  7 / 87 MEDLINE  
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[PMID]:9823777
[Au] Autor:Tian Y; Xie XK; Piao FY; Yamauchi T
[Ad] Endereço:Department of Public Health, School of Medicine, Mie University, Tsu, Japan. tianying@doc.medic.mie-u.ac.jp
[Ti] Título:Delayed neuropathy and inhibition of soluble neuropathy target esterase following the administration of organophosphorus compounds to hens.
[So] Source:Tohoku J Exp Med;185(3):161-71, 1998 Jul.
[Is] ISSN:0040-8727
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Delayed neuropathy and inhibition of soluble neuropathy target esterase (NTE) and acetylcholinesterase (AChE) activities in different regions of brain and spinal cord of adult hens were studied after the intravenous administration of leptophos (30 mg/kg), tri-o-cresyl phosphate (TOCP 40 mg/kg) or dipterex (200 mg/kg). The level of NTE activity varied according to the regions of the central nervous system (CNS) of the control (normal) hen, being higher in the cerebrum (74.1 micromol of phenyl valerate hydrolyzed/10 minutes/mg protein) and in the cerebellum (68.7), and lower in the spinal cord (44.5 in cervical, 55.6 in thoracic and 50.0 in lumbar cord). Hens given leptophos and TOCP demonstrated delayed neuropathy with obvious inhibition of NTE, but the times of onset and the degrees of peak inhibition of NTE activity were different: 6-24 hours after dosing and 73-82% of normal activity for leptophos, and 24-48 hours and 45-80% for TOCP, respectively. Furthermore, the average inhibition of NTE during 6-48 hours after dosing, (called here 'period average inhibition') was also significantly different between the leptophos group (63-73%) and TOCP group (40-64%). Hens given dipterex did not demonstrate delayed neuropathy, and had the least peak inhibition and period average inhibition of NTE activity among the 3 groups. Ratios of NTE inhibition/AChE inhibition were higher in the leptophos group (0.91-1.24) and TOCP group (1.13-2.45) than in the dipterex group (0.25-0.79). These results indicate that the distribution of NTE in the soluble fraction of membrane proteins is different in different regions of the CNS, and that the degree of peak inhibition of NTE activity and the time of onset of peak inhibition induced by organophosphorus compounds (OPs) also differ for different OPs. Thus, practical and useful NTE measurements should identify the peak inhibition and period inhibition in several nervous tissue regions.
[Mh] Termos MeSH primário: Hidrolases de Éster Carboxílico/antagonistas & inibidores
Doenças do Sistema Nervoso/induzido quimicamente
Compostos Organofosforados/farmacologia
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Animais
Galinhas
Feminino
Injeções Intravenosas
Leptofós/farmacologia
Doenças do Sistema Nervoso/enzimologia
Doenças do Sistema Nervoso/fisiopatologia
Valores de Referência
Solubilidade
Fatores de Tempo
Triclorfon/farmacologia
Tritolil Fosfatos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organophosphorus Compounds); 0 (Tritolyl Phosphates); C45E8FUG3Z (Leptophos); DBF2DG4G2K (Trichlorfon); EC 3.1.1.- (Carboxylic Ester Hydrolases); EC 3.1.1.- (neurotoxic esterase); EC 3.1.1.7 (Acetylcholinesterase); X8II18JD0A (tri-o-cresyl phosphate)
[Em] Mês de entrada:9901
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:981121
[St] Status:MEDLINE


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[PMID]:9198007
[Au] Autor:Piao FY; Xie XK; Kitabatake M; Yamauchi T
[Ad] Endereço:Department of Public Health, School of Medicine, Mie University, Japan.
[Ti] Título:Transfer of leptophos in hen eggs and tissues of embryonic rats.
[So] Source:J Toxicol Sci;22(2):99-109, 1997 May.
[Is] ISSN:0388-1350
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:To estimate the delayed neurotoxic effect of OPs on the next generation, we tried two examinations; one was on the distribution of leptophos in tissues and eggs of hens which are highly susceptible to the delayed neurotoxic effect of OPs but have no placenta, and the other was on the concentration of OPs in tissues of both pregnant and embryonic rats which are not susceptible to the delayed neurotoxic effect but have placenta, after leptophos was administered to the mother in both experiments. First, organophosphorus compound-induced delayed neurotoxicity (OPIDN) was checked in 4 hens and the concentration of leptophos was determined in the other 16 hens after 20 adult laying hens were given 30 mg/kg leptophos (iv), a neurotoxic organophosphate. Three out of 4 hens treated with leptophos showed OPIDN. The concentration of leptophos decreased sharply in the blood, liver, brain and spinal cord from 24 to 48 hr after leptophos administration, but clearance of leptophos was relatively slow in the ovary. Leptophos in laid egg yolk was detected every day for 10 days, and the highest concentration of leptophos in egg yolk was observed on the 6th day after administration to hens. Secondly, in order to investigate the transfer of leptophos to the embryo through the placenta, we divided the thirty-two pregnant rats into 2 groups. The first group received 10 mg/kg leptophos intraperitoneally on the 17th day of pregnancy and the second received 20 mg/kg leptophos on the same day. The time-course of leptophos concentration in the tissues of pregnant and embryonic rats was checked, and the correlation between findings in the pregnant rats and the embryos was determined. The time-course of leptophos concentration in the blood, liver, brain and placenta of the rats was similar to that in hens. Leptophos concentration in the liver and brain of the embryos was equal to approximately 60% of leptophos concentration in each tissue of the pregnant rats, and the concentration of leptophos in the liver and brain of embryonic rats correlated with that in the blood and placenta of pregnant rats (p < 0.01). In both groups treated with 10 and 20 mg/kg leptophos, the concentrations of leptophos in the liver and brain of embryos were lower than that of pregnant rats in the early period after dosing, but the concentrations in embryos were inversely higher than those in pregnant rats in the latter period (48 hr). Compared with the biological half-lives of leptophos in the liver and brain of pregnant rats, these parameters in embryonic rats were 1.58 and 1.87 times, respectively. These results indicate that some of the fat-soluble organophosphorus compounds readily pass through the blood-placenta barrier into the embryos and accumulate there. Therefore, the neurobehavioral development of F1 rats exposed to some organophosphorus compounds through the placenta of pregnant rats should be further examined.
[Mh] Termos MeSH primário: Inseticidas/farmacocinética
Leptofós/farmacocinética
Neurotoxinas/farmacocinética
Efeitos Tardios da Exposição Pré-Natal
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/efeitos dos fármacos
Encéfalo/efeitos dos fármacos
Encéfalo/embriologia
Encéfalo/metabolismo
Embrião de Galinha/efeitos dos fármacos
Embrião de Galinha/metabolismo
Cromatografia Gasosa
Relação Dose-Resposta a Droga
Gema de Ovo/química
Gema de Ovo/efeitos dos fármacos
Feminino
Meia-Vida
Injeções Intraperitoneais
Inseticidas/administração & dosagem
Inseticidas/toxicidade
Leptofós/administração & dosagem
Leptofós/toxicidade
Fígado/efeitos dos fármacos
Fígado/embriologia
Fígado/metabolismo
Masculino
Neurotoxinas/administração & dosagem
Neurotoxinas/toxicidade
Ovário/efeitos dos fármacos
Ovário/embriologia
Ovário/metabolismo
Placenta/metabolismo
Gravidez
Ratos
Ratos Wistar
Medula Espinal/efeitos dos fármacos
Medula Espinal/embriologia
Medula Espinal/metabolismo
Distribuição Tecidual
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Neurotoxins); C45E8FUG3Z (Leptophos)
[Em] Mês de entrada:9708
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:970501
[St] Status:MEDLINE


  9 / 87 MEDLINE  
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[PMID]:8720167
[Au] Autor:Piao FY; Kitabatake M; Xie XK; Yamauchi T
[Ad] Endereço:Department of Public Health, School of Medicine, Mie University, Tsul, Japan.
[Ti] Título:Effects of various post-treatment by phenylmethylsulfonyl fluoride on delayed neurotoxicity induced by leptophos.
[So] Source:J Toxicol Sci;20(5):609-17, 1995 Nov.
[Is] ISSN:0388-1350
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Delayed neurotoxicity induced by leptophos, an organophosphorus insecticide, was intensified in hens when phenylmethylsulfonyl fluoride (PMSF) at dose of 30, 60, and 120 mg/kg body weight was administered at different time intervals (24 hr, 3 days, and 5 days) for each dose of PMSF after the hens were exposed to 30 mg/kg (i.v.) of leptophos. The scores for organophosphorus-induced delayed neuropathy (OPIDN) in all groups treated with 120 mg/kg PMSF were significantly higher than those in the group treated with leptophos only (P<0.05 or P<0.01) and the initial signs of OPIDN appeared 2 or 3 days earlier in the former groups than in the latter group. Further, the greater the PMSF post-treatment dose, the more severe were the signs of OPIDN. These findings indicate that post-treatment with PMSF promotes leptophos-induced OPIDN and reduces the period to OPIDN onset. We also examined the effects of various time intervals between PMSF administration and exposure to leptophos on the development of OPIDN. The OPIDN scores in the two groups of hen treated with PMSF on days 3 and 5 after leptophos exposure were high, especially the score of the 5 days treated group became significantly higher on the 18th and 19th day after leptophos administration than even that of the 24 hr treated group with PMSF (P<0.05). These findings suggest that variations in both the dose of PMSF and the time intervals of PMSF post-treatment may affect the delayed neurotoxicity induced by leptophos. Moreover, these results also indicate that PMSF should not be used for either the treatment or the prevention of OPIDN.
[Mh] Termos MeSH primário: Inseticidas/toxicidade
Leptofós/toxicidade
Sistema Nervoso/efeitos dos fármacos
Fluoreto de Fenilmetilsulfonil/farmacologia
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Galinhas
Feminino
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 57KD15003I (Phenylmethylsulfonyl Fluoride); C45E8FUG3Z (Leptophos)
[Em] Mês de entrada:9706
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:951101
[St] Status:MEDLINE


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[PMID]:7685784
[Au] Autor:Anthony J
[Ad] Endereço:School of Kinesiology, Simon Fraser University, Burnaby, B.C.
[Ti] Título:Acetylcholinesterase activity and degenerative changes in various segments of the spinal cord of hens induced by ingestion of subchronic levels of leptophos.
[So] Source:J Environ Sci Health B;28(3):275-90, 1993 Jun.
[Is] ISSN:0360-1234
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Changes in acetylcholinesterase (AChE) levels in the brain and various segments of the spinal cord of birds fed subchronic repeated oral doses of 0-(4-bromo-2,5 dichlorophenyl) 0-methyl phenylphosphonothioate, (leptophos, 15 mg/kg/day) is reported. The effect of leptophos on the histological structure of the spinal cord has also been described. Three birds each of four groups tested were sacrificed 7, 14, 21 and 35 days after treatment. AChE levels in the cervical, thoracic and lumbar cord were depressed from 29%-33% after 7 days to 34%-56% after 14 days of leptophos administration. This was followed by a gradual recovery at 21 days post treatment with a further decrease (23%-48%) at 35 days post treatment. Similar decreases in brain AChE levels were also observed. Spinal cord lesions in the cervical and thoracic segments were restricted to the anterior and lateral columns, while lumbar cord lesions were restricted to the anterior column. It is concluded that routine histopathology correlated with AChE levels in the cervical, thoracic and lumbar sections of the spinal cord may be useful in monitoring the onset of clinical neuropathy in laboratory animals fed prolonged subacute doses of neurotoxicants.
[Mh] Termos MeSH primário: Inibidores da Colinesterase/toxicidade
Doenças Desmielinizantes/induzido quimicamente
Leptofós/toxicidade
Degeneração Neural
Medula Espinal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Encéfalo/enzimologia
Galinhas
Inibidores da Colinesterase/administração & dosagem
Feminino
Leptofós/administração & dosagem
Medula Espinal/enzimologia
Medula Espinal/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cholinesterase Inhibitors); C45E8FUG3Z (Leptophos)
[Em] Mês de entrada:9307
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:930601
[St] Status:MEDLINE



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