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[PMID]:29338042
[Au] Autor:Rimkus SA; Wassarman DA
[Ad] Endereço:Department of Medical Genetics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.
[Ti] Título:A pharmacological screen for compounds that rescue the developmental lethality of a Drosophila ATM mutant.
[So] Source:PLoS One;13(1):e0190821, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ataxia-telangiectasia (A-T) is a neurodegenerative disease caused by mutation of the A-T mutated (ATM) gene. ATM encodes a protein kinase that is activated by DNA damage and phosphorylates many proteins, including those involved in DNA repair, cell cycle control, and apoptosis. Characteristic biological and molecular functions of ATM observed in mammals are conserved in Drosophila melanogaster. As an example, conditional loss-of-function ATM alleles in flies cause progressive neurodegeneration through activation of the innate immune response. However, unlike in mammals, null alleles of ATM in flies cause lethality during development. With the goals of understanding biological and molecular roles of ATM in a whole animal and identifying candidate therapeutics for A-T, we performed a screen of 2400 compounds, including FDA-approved drugs, natural products, and bioactive compounds, for modifiers of the developmental lethality caused by a temperature-sensitive ATM allele (ATM8) that has reduced kinase activity at non-permissive temperatures. Ten compounds reproducibly suppressed the developmental lethality of ATM8 flies, including Ronnel, which is an organophosphate. Ronnel and other suppressor compounds are known to cause mitochondrial dysfunction or to inhibit the enzyme acetylcholinesterase, which controls the levels of the neurotransmitter acetylcholine, suggesting that detrimental consequences of reduced ATM kinase activity can be rescued by inhibiting the function of mitochondria or increasing acetylcholine levels. We carried out further studies of Ronnel because, unlike the other compounds that suppressed the developmental lethality of homozygous ATM8 flies, Ronnel was toxic to the development of heterozygous ATM8 flies. Ronnel did not affect the innate immune response of ATM8 flies, and it further increased the already high levels of DNA damage in brains of ATM8 flies, but its effects were not harmful to the lifespan of rescued ATM8 flies. These results provide new leads for understanding the biological and molecular roles of ATM and for the treatment of A-T.
[Mh] Termos MeSH primário: Proteínas Mutadas de Ataxia Telangiectasia/genética
Drosophila melanogaster/efeitos dos fármacos
Drosophila melanogaster/genética
[Mh] Termos MeSH secundário: Alelos
Animais
Dano ao DNA
Proteínas de Drosophila/genética
Drosophila melanogaster/crescimento & desenvolvimento
Avaliação Pré-Clínica de Medicamentos/métodos
Feminino
Genes de Insetos/efeitos dos fármacos
Genes Letais/efeitos dos fármacos
Imunidade Inata/efeitos dos fármacos
Imunidade Inata/genética
Masculino
Mutação
Degeneração Neural/genética
Compostos Organotiofosforados/farmacologia
Fenótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Drosophila Proteins); 0 (Organothiophosphorus Compounds); 89RAG7SB3B (ronnel); EC 2.7.11.1 (ATM protein, Drosophila); EC 2.7.11.1 (Ataxia Telangiectasia Mutated Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190821


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[PMID]:27773723
[Au] Autor:Langston JL; Myers TM
[Ad] Endereço:Analytical Toxicology Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, USA.
[Ti] Título:VX toxicity in the Göttingen minipig.
[So] Source:Toxicol Lett;264:12-19, 2016 Dec 15.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present experiments determined the intramuscular LD of VX in male Göttingen minipigs at two stages of development. In pubertal animals (115 days old), the LD of VX was indeterminate, but approximated 33.3µg/kg. However, in sexually mature animals (152 days old), the LD was estimated to be only 17.4µg/kg. Signs of nerve agent toxicity in the Göttingen minipig were similar to those described for other species, with some notable exceptions (such as urticaria and ejaculation). Latencies to the onset of sustained convulsions were inversely related to the administered dose of VX in both ages of minipigs. Additionally, actigraphy was used to quantify the presence of tremor and convulsions and, in some cases, was useful for precisely estimating time of death. The main finding indicates that in minipigs, as in other species, even relatively small differences in age can substantially alter the toxicity of nerve agents. Additionally, actigraphy can serve as a non-invasive method of characterizing the tremors and convulsions that often accompany nerve agent intoxication.
[Mh] Termos MeSH primário: Substâncias para a Guerra Química/toxicidade
Compostos Organotiofosforados/toxicidade
[Mh] Termos MeSH secundário: Envelhecimento
Animais
Injeções Intramusculares
Dose Letal Mediana
Masculino
Atividade Motora/efeitos dos fármacos
Compostos Organotiofosforados/administração & dosagem
Convulsões/induzido quimicamente
Maturidade Sexual/efeitos dos fármacos
Suínos
Porco Miniatura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chemical Warfare Agents); 0 (Organothiophosphorus Compounds); 9A4381183B (VX)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28456303
[Au] Autor:Han Y; Song S; Wu H; Zhang J; Ma E
[Ad] Endereço:Institute of Applied Biology, Shanxi University, 92 Wucheng Road, Taiyuan, Shanxi 030006, China; School of Life Science, Shanxi University, 92 Wucheng Road, Taiyuan, Shanxi 030006, China; Shanxi Key Laboratory of Integrated Pest Management in Agriculture, 92 Wucheng Road, Taiyuan, Shanxi 030006, Chi
[Ti] Título:Antioxidant enzymes and their role in phoxim and carbaryl stress in Caenorhabditis elegans.
[So] Source:Pestic Biochem Physiol;138:43-50, 2017 May.
[Is] ISSN:1095-9939
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pesticide exposure can induce oxidative stress and cause changes to antioxidant enzymes in living organisms. In the present study, the effects of phoxim (an organophosphorus insecticide) and carbaryl (a carbamate insecticide) on antioxidant enzyme activity and gene expression were investigated in the model organism Caenorhabditis elegans. The results show that phoxim exposure can induce superoxide dismutase (SOD) and catalase (CAT) activities and decrease glutathione peroxidase (GPx) activity at lower concentrations. The expression levels of sod-3, sod-5, ctl-1, gpx-6, and gpx-8 were up-regulated after treatment with phoxim. The mRNA expression levels of sod-5, ctl-1 and gpx-6 were increased approximately 70-, 170- and 130-fold, respectively, in the 0.25mM treatment group compared to the control group. Carbaryl exposure decreased SOD activity and induced CAT and GPx activities. The addition of carbaryl up-regulated the expression of sod-5, ctl-1, ctl-3 and gpx-8. Specifically, ctl-1 expression increased approximately 10-fold, and gpx-8 expression increased <30-fold in the 0.5mM treatment group relative to the control group. The transcript level of sod-5 increased >20-fold, and ctl-3 increased approximately 10-fold in the 1mM treatment group. The functions of the antioxidant enzymes during oxidative stress caused by the two insecticides were investigated using deletion mutants. The LC values phoxim for the of sod-3 (tm760), sod-5 (tm1146), ctl-1 (ok1242), ctl-3 (ok2042) and gpx-8 (tm2108) mutant strains were lower than those observed for the N2 strain. The LC values of carbaryl for the ctl-1 (ok1242), ctl-3 (ok2042) and gpx-6 (tm2535) deletion mutant strains decreased in comparison to the N2 strain. The results suggest that these two insecticides caused oxidative stress and changed altered the antioxidant enzyme activities and their gene expressions in C. elegans. The sod-3, sod-5, ctl-1, ctl-3, gpx-6, and gpx-8 encoding enzymes may play roles in defending cells from oxidative stress caused by these two insecticides.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Caenorhabditis elegans/efeitos dos fármacos
Carbaril/toxicidade
Inseticidas/toxicidade
Compostos Organotiofosforados/toxicidade
Estresse Fisiológico/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Caenorhabditis elegans/enzimologia
Regulação Enzimológica da Expressão Gênica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Insecticides); 0 (Organothiophosphorus Compounds); 6F5V775VPO (phoxim); R890C8J3N1 (Carbaryl)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:28986598
[Au] Autor:Liu H; Anders F; Thanos S; Mann C; Liu A; Grus FH; Pfeiffer N; Prokosch-Willing V
[Ad] Endereço:Department of Ophthalmology, University Medical Centre, Johannes Gutenberg University Mainz, Germany.
[Ti] Título:Hydrogen Sulfide Protects Retinal Ganglion Cells Against Glaucomatous Injury In Vitro and In Vivo.
[So] Source:Invest Ophthalmol Vis Sci;58(12):5129-5141, 2017 Oct 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Hydrogen sulfide (H2S) is recognized as a novel third signaling molecule and gaseous neurotransmitter. Recently, cell protective properties within the central nervous and cardiovascular system have been proposed. Our purpose was to analyze the expression and neuroprotective effects of H2S in experimental models of glaucoma. Methods: Elevated IOP was induced in Sprague-Dawley rats by means of episcleral vein cauterization. After 7 weeks, animals were killed and the retina was analyzed with label-free mass spectrometry. In vitro, retinal explants were exposed to elevated hydrostatic pressure or oxidative stress (H2O2), with and without addition of a slow-releasing H2S donor Morpholin-4-ium-methoxyphenyl-morpholino-phosphinodithioate (GYY4137). In vivo, GYY4137 was injected intravitreally in animals with acute ischemic injury or optic nerve crush. Brn3a+ retinal ganglion cells (RGCs) were counted in retinal flat mounts and compared. Optical coherence tomography (OCT) was performed to examine the vessels. Comparisons were made by t-test and ANOVA (P < 0.05). Results: IOP elevation caused significant RGC loss (P < 0.001); 3-mercaptosulfurtransferase, an H2S producing enzyme, showed a 3-fold upregulation within the retina after IOP elevation. GYY4137 protected RGCs against elevated pressure and oxidative stress in vitro depending on the concentration used (P < 0.005). In vivo, intravitreal administration of GYY4137 preserved RGCs from acute ischemic injury and optic nerve crush (P < 0.0001). Retinal vessel diameters enlarged after intravitreal GYY4137 injection (P < 0.0001). Conclusions: H2S is specifically regulated in experimental glaucoma. By scavenging reactive oxygen species and dilating retinal vessels, H2S may protect RGCs from pressure and oxidative stress-induced RGC loss in vitro and in vivo. Therefore, H2S might be a novel neuroprotectant in glaucoma.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Glaucoma/prevenção & controle
Sulfeto de Hidrogênio/farmacologia
Fármacos Neuroprotetores/farmacologia
Traumatismos do Nervo Óptico/prevenção & controle
Células Ganglionares da Retina/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Feminino
Peróxido de Hidrogênio/toxicidade
Pressão Hidrostática
Pressão Intraocular/efeitos dos fármacos
Morfolinas/farmacologia
Compressão Nervosa
Compostos Organotiofosforados/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GYY 4137); 0 (Morpholines); 0 (Neuroprotective Agents); 0 (Organothiophosphorus Compounds); BBX060AN9V (Hydrogen Peroxide); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171008
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22200


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[PMID]:28977605
[Au] Autor:Pichette J; Fynn-Sackey N; Gagnon J
[Ad] Endereço:Laurentian University, Department of Biology, Sudbury, Ontario P3E 2C6, Canada.
[Ti] Título:Hydrogen Sulfide and Sulfate Prebiotic Stimulates the Secretion of GLP-1 and Improves Glycemia in Male Mice.
[So] Source:Endocrinology;158(10):3416-3425, 2017 Oct 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recently, the gastrointestinal microbiome, and its metabolites, has emerged as a potential regulator of host metabolism. However, to date little is known on the precise mechanisms of how this regulation occurs. Hydrogen sulfide (H2S) is abundantly produced in the colon by sulfate-reducing bacteria (SRB). H2S is a bioactive gas that plays regulatory roles in many systems, including metabolic hormone regulation. This gas metabolite is produced in close proximity to the glucagonlike peptide-1 (GLP-1)-secreting cells in the gut epithelium. GLP-1 is a peptide hormone that plays pivotal roles in both glucose homeostasis and appetite regulation. We hypothesized that H2S can directly regulate GLP-1 secretion. We demonstrated that H2S donors (NaHS and GYY4137) directly stimulate GLP-1 secretion in murine L-cells (GLUTag) and that this occurs through p38 mitogen-activated protein kinase without affecting cell viability. We then increased SRB in mice by supplementing the diet with a prebiotic chondroitin sulfate for 4 weeks. Mice treated with chondroitin sulfate had elevated Desulfovibrio piger levels in the feces and increased colonic and fecal H2S concentration. These animals also had enhanced GLP-1 and insulin secretion, improved oral glucose tolerance, and reduced food consumption. These results indicate that H2S plays a stimulatory role in GLP-1 secretion and that sulfate prebiotics can enhance GLP-1 release and its downstream metabolic actions.
[Mh] Termos MeSH primário: Sulfatos de Condroitina/farmacologia
Colo/efeitos dos fármacos
Microbioma Gastrointestinal/efeitos dos fármacos
Peptídeo 1 Semelhante ao Glucagon/efeitos dos fármacos
Sulfeto de Hidrogênio/metabolismo
Mucosa Intestinal/efeitos dos fármacos
Morfolinas/farmacologia
Compostos Organotiofosforados/farmacologia
Prebióticos
Sulfetos/farmacologia
[Mh] Termos MeSH secundário: Animais
Western Blotting
Colo/metabolismo
DNA Bacteriano/análise
Desulfovibrio/efeitos dos fármacos
Ingestão de Alimentos/efeitos dos fármacos
Fezes/química
Microbioma Gastrointestinal/genética
Peptídeo 1 Semelhante ao Glucagon/secreção
Teste de Tolerância a Glucose
Insulina/secreção
Mucosa Intestinal/secreção
Masculino
Camundongos
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (GYY 4137); 0 (Insulin); 0 (Morpholines); 0 (Organothiophosphorus Compounds); 0 (Prebiotics); 0 (Sulfides); 89750-14-1 (Glucagon-Like Peptide 1); 9007-28-7 (Chondroitin Sulfates); FWU2KQ177W (sodium bisulfide); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00391


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[PMID]:28851585
[Au] Autor:Worek F; Wosar A; Baumann M; Thiermann H; Wille T
[Ad] Endereço:Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany. Electronic address: franzworek@bundeswehr.org.
[Ti] Título:Development of a sensitive, generic and easy to use organophosphate skin disclosure kit.
[So] Source:Toxicol Lett;280:190-194, 2017 Oct 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Various organophosphorus compounds (OP), primarily the nerve agent VX and other V-agents, are highly toxic to humans after skin exposure. Percutaneous exposure by such OP results in a delayed onset of toxic signs which enables the initiation of specific countermeasures if contamination is detected rapidly. Presently available mobile detection systems can hardly detect skin exposure by low volatile OP. In order to fill this gap an OP skin disclosure kit was developed which should fulfill different requirements, i.e. a high sensitivity, coverage of human toxic OP, easy handling, rapid results, small dimension and weight. The kit includes a cotton swab to sample skin, human AChE as target and chemicals for a color reaction based on the Ellman assay which is recorded by visual inspection. OP is dissolved from the sampler in a test tube filled with phosphate buffer (0.1M, pH 7.4) and incubated with lyophilized human AChE for 1min. The reaction with acetylthiocholine and 5,5'-dithio-bis-2-nitrobenzoic acid (1min) results in a rich yellow color in the absence of OP and in contrast, in transparent or pale yellow buffer in the presence of OP. At the recommended conditions, the limit of detection is 100ng VX and Russian VX and 50ng Chinese VX on plain surface and 200ng VX on rat skin. With activated pesticides, paraoxon and malaoxon, a concentration of ∼10µg can be detected on plain surface. The ready-to-use kit has a weight of 16g and a size of 10×12×1cm. In the end, this kit has the potential to fill a major gap and to enable timely detection of OP skin exposure and initiation of life-saving countermeasures.
[Mh] Termos MeSH primário: Compostos Organofosforados/química
Compostos Organofosforados/toxicidade
Compostos Organotiofosforados/química
Compostos Organotiofosforados/toxicidade
Kit de Reagentes para Diagnóstico
[Mh] Termos MeSH secundário: Administração Cutânea
Animais
Substâncias para a Guerra Química/química
Colorimetria
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chemical Warfare Agents); 0 (Organophosphorus Compounds); 0 (Organothiophosphorus Compounds); 0 (Reagent Kits, Diagnostic); 9A4381183B (VX)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE


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[PMID]:28678475
[Au] Autor:Chu Y; Williams NH; Hengge AC
[Ad] Endereço:Department of Chemistry and Biochemistry, Utah State University , Logan, Utah 84322-0300, United States.
[Ti] Título:Transition States and Control of Substrate Preference in the Promiscuous Phosphatase PP1.
[So] Source:Biochemistry;56(30):3923-3933, 2017 Aug 01.
[Is] ISSN:1520-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Catalytically promiscuous enzymes are an attractive frontier for biochemistry, because enzyme promiscuities not only plausibly explain enzyme evolution through the mechanism of gene duplication but also could provide an efficient route to changing the catalytic function of proteins by mimicking this evolutionary process. PP1γ is an effectively promiscuous phosphatase for the hydrolysis of both monoanionic and dianionic phosphate ester-based substrates. In addition to its native phosphate monoester substrate, PP1γ catalyzes the hydrolysis of aryl methylphosphonates, fluorophosphate esters, phosphorothioate esters, and phosphodiesters, with second-order rate accelerations that fall within the narrow range of 10 -10 . In contrast to the different transition states in the uncatalyzed hydrolysis reactions of these substrates, PP1γ catalyzes their hydrolysis through similar transition states. PP1γ does not catalyze the hydrolysis of a sulfate ester, which is unexpected. The PP1γ active site is tolerant of variations in the geometry of bound ligands, which permit the effective catalysis even of substrates whose steric requirements may result in perturbations to the positioning of the transferring group, both in the initial enzyme-substrate complex and in the transition state. The conservative mutation of arginine 221 to lysine results in a mutant that is a more effective catalyst toward monoanionic substrates. The surprising conversion of substrate preference lends support to the notion that mutations following gene duplication can result in an altered enzyme with different catalytic capabilities and preferences and may provide a pathway for the evolution of new enzymes.
[Mh] Termos MeSH primário: Modelos Moleculares
Proteína Fosfatase 1/metabolismo
[Mh] Termos MeSH secundário: Substituição de Aminoácidos
Arginina/química
Ligação Competitiva
Biocatálise
Domínio Catalítico
Inibidores Enzimáticos/farmacologia
Estabilidade Enzimática
Evolução Molecular
Seres Humanos
Ligações de Hidrogênio
Hidrólise
Ligantes
Lisina/química
Conformação Molecular
Mutagênese Sítio-Dirigida
Mutação
Nitrofenóis/química
Nitrofenóis/metabolismo
Organofosfonatos/química
Organofosfonatos/metabolismo
Compostos Organofosforados/química
Compostos Organofosforados/metabolismo
Compostos Organotiofosforados/química
Compostos Organotiofosforados/metabolismo
Proteína Fosfatase 1/antagonistas & inibidores
Proteína Fosfatase 1/química
Proteína Fosfatase 1/genética
Proteínas Recombinantes/química
Proteínas Recombinantes/metabolismo
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4-nitrophenyl phosphorothioate); 0 (Enzyme Inhibitors); 0 (Ligands); 0 (Nitrophenols); 0 (Organophosphonates); 0 (Organophosphorus Compounds); 0 (Organothiophosphorus Compounds); 0 (Recombinant Proteins); 330-13-2 (nitrophenylphosphate); 94ZLA3W45F (Arginine); EC 3.1.3.16 (PPP1CC protein, human); EC 3.1.3.16 (Protein Phosphatase 1); K3Z4F929H6 (Lysine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE
[do] DOI:10.1021/acs.biochem.7b00441


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[PMID]:28672113
[Au] Autor:Zhao Y; Wang Q; Wang Y; Zhang Z; Wei Y; Liu F; Zhou C; Mu W
[Ti] Título:Chlorfenapyr, a Potent Alternative Insecticide of Phoxim To Control Bradysia odoriphaga (Diptera: Sciaridae).
[So] Source:J Agric Food Chem;65(29):5908-5915, 2017 Jul 26.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bradysia odoriphaga is the major pest affecting Chinese chive production, and in China, it has developed widespread resistance to organophosphorus insecticides. Chlorfenapyr is a promising pyrrole insecticide with a unique mechanism of action that does not confer cross-resistance to neurotoxic insecticides. However, the effect of chlorfenapyr on organophosphate-resistant B. odoriphaga is not well understood. The present study evaluated the potential of chlorfenapyr for the control of phoxim-resistant B. odoriphaga. The results showed that chlorfenapyr had significant insecticidal activity to B. odoriphaga in multiple developmental stages, and there were no significant differences in susceptibility between the field (phoxim-resistant) and laboratory (phoxim-susceptible) populations. The pot experiment and field trials confirmed the results of our laboratory bioassays. In the field trial, chlorfenapyr applied at 3.0, 6.0, or 12.0 kg of active ingredient (a.i.)/ha significantly decreased the number of B. odoriphaga and improved the yield compared to phoxim at 6.0 kg of a.i./ha and the control conditions. Moreover, the final residues of chlorfenapyr on plants were below the maximum residue limits (MRLs) as a result of its non-systemic activity. These results demonstrate that chlorfenapyr has potential as a potent alternative to phoxim for controlling B. odoriphaga.
[Mh] Termos MeSH primário: Dípteros/efeitos dos fármacos
Inseticidas/farmacologia
Compostos Organotiofosforados/farmacologia
Piretrinas/farmacologia
[Mh] Termos MeSH secundário: Animais
China
Dípteros/crescimento & desenvolvimento
Controle de Insetos
Larva/efeitos dos fármacos
Larva/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Organothiophosphorus Compounds); 0 (Pyrethrins); 6F5V775VPO (phoxim); NWI20P05EB (chlorfenapyr)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b02098


  9 / 3715 MEDLINE  
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[PMID]:28655058
[Au] Autor:Laitinen TT; Puolakka E; Ruohonen S; Magnussen CG; Smith KJ; Viikari JSA; Heinonen OJ; Kartiosuo N; Hutri-Kähönen N; Kähönen M; Jokinen E; Laitinen TP; Tossavainen P; Pulkki-Råback L; Elovainio M; Raitakari OT; Pahkala K; Juonala M
[Ad] Endereço:The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
[Ti] Título:Association of Socioeconomic Status in Childhood With Left Ventricular Structure and Diastolic Function in Adulthood: The Cardiovascular Risk in Young Finns Study.
[So] Source:JAMA Pediatr;171(8):781-787, 2017 Aug 01.
[Is] ISSN:2168-6211
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Increased left ventricular (LV) mass and diastolic dysfunction are associated with cardiovascular disease. Prospective data on effects of childhood socioeconomic status (SES) on measures of LV structure and function are lacking. Objective: To examine whether family SES in childhood was associated with LV mass and diastolic function after adjustment for conventional cardiovascular disease risk factors in childhood and adulthood. Design, Setting, and Participants: The analyses were performed in 2016 using data gathered in 1980 and 2011 within the longitudinal population-based Cardiovascular Risk in Young Finns Study. The sample comprised 1871 participants who reported family SES at ages 3 to 18 years and were evaluated for LV structure and function 31 years later. Exposures: Socioeconomic status was characterized as annual income of the family and classified on a 3-point scale. Main Outcomes and Measures: Left ventricular mass indexed according to height at the allometric power of 2.7 and the E/e' ratio describing LV diastolic performance at ages 34 to 49 years. Results: The participants were aged 3 to 18 years at baseline (mean [SD], 10.8 [5.0] years), and the length of follow-up was 31 years. Family SES was inversely associated with LV mass (mean [SD] LV mass index, 31.8 [6.7], 31.0 [6.6], and 30.1 [6.4] g/m2.7 in the low, medium, and high SES groups, respectively; differences [95% CI], 1.7 [0.6 to 2.8] for low vs high SES; 0.8 [-0.3 to 1.9] for low vs medium; and 0.9 [0.1 to 1.6] for medium vs high; overall P = .001) and E/e' ratio (mean [SD] E/e' ratio, 5.0 [1.0], 4.9 [1.0], and 4.7 [1.0] in the low, medium, and high SES groups, respectively; differences [95% CI], 0.3 [0.1 to 0.4] for low vs high SES; 0.1 [-0.1 to 0.3] for low vs medium; and 0.2 [0 to 0.3] for medium vs high; overall P < .001) in adulthood. After adjustment for age, sex, and conventional cardiovascular disease risk factors in childhood and adulthood, and participants' own SES in adulthood, the relationship with LV mass (differences [95% CI], 1.5 [0.2 to 2.8] for low vs high SES; 1.3 [0 to 2.6] for low vs medium; and 0.2 [-0.6 to 1.0] for medium vs high; P = .03) and E/e' ratio (differences [95% CI], 0.2 [0 to 0.5] for low vs high SES; 0.1 [-0.1 to 0.4] for low vs medium; and 0.1 [0 to 0.3] for medium vs high; P = .02) remained significant. Conclusions and Relevance: Low family SES was associated with increased LV mass and impaired diastolic performance more than 3 decades later. These findings emphasize that approaches of cardiovascular disease prevention must be directed also to the family environment of the developing child.
[Mh] Termos MeSH primário: Comportamentos Relacionados com a Saúde
Nível de Saúde
Ventrículos do Coração/fisiopatologia
Pobreza
Disfunção Ventricular Esquerda/epidemiologia
Disfunção Ventricular Esquerda/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Doença da Artéria Coronariana/epidemiologia
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
Compostos Organotiofosforados
Fatores de Risco
Ajustamento Social
Fatores Socioeconômicos
Função Ventricular Esquerda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organothiophosphorus Compounds); 9A4381183B (VX)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1001/jamapediatrics.2017.1085


  10 / 3715 MEDLINE  
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[PMID]:28628635
[Au] Autor:E Pereira A; Souza D; Zukoff SN; Meinke LJ; Siegfried BD
[Ad] Endereço:Division of Plant Sciences, University of Missouri, Columbia, Missouri, United States of America.
[Ti] Título:Cross-resistance and synergism bioassays suggest multiple mechanisms of pyrethroid resistance in western corn rootworm populations.
[So] Source:PLoS One;12(6):e0179311, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recently, resistance to the pyrethroid bifenthrin was detected and confirmed in field populations of western corn rootworm, Diabrotica virgifera virgifera LeConte from southwestern areas of Nebraska and Kansas. As a first step to understand potential mechanisms of resistance, the objectives of this study were i) to assess adult mortality at diagnostic concentration-LC99 to the pyrethroids bifenthrin and tefluthrin as well as DDT, ii) estimate adult and larval susceptibility to the same compounds as well as the organophosphate methyl-parathion, and iii) perform synergism experiments with piperonyl butoxide (PBO) (P450 inhibitor) and S,S,S-tributyl-phosphorotrithioate (DEF) (esterase inhibitor) in field populations. Most of the adult field populations exhibiting some level of bifenthrin resistance exhibited significantly lower mortality to both pyrethroids and DDT than susceptible control populations at the estimated LC99 of susceptible populations. Results of adult dose-mortality bioassays also revealed elevated LC50 values for bifenthrin resistant populations compared to the susceptible control population with resistance ratios ranging from 2.5 to 5.5-fold for bifenthrin, 28 to 54.8-fold for tefluthrin, and 16.3 to 33.0 for DDT. These bioassay results collectively suggest some level of cross-resistance between the pyrethroids and DDT. In addition, both PBO and DEF reduced the resistance ratios for resistant populations although there was a higher reduction in susceptibility of adults exposed to PBO versus DEF. Susceptibility in larvae varied among insecticides and did not correlate with adult susceptibility to tefluthrin and DDT, as most resistance ratios were < 5-fold when compared to the susceptible population. These results suggest that both detoxifying enzymes and target site insensitivity might be involved as resistance mechanisms.
[Mh] Termos MeSH primário: Coleópteros
Resistência a Inseticidas/efeitos dos fármacos
Inseticidas
Piretrinas
Zea mays/parasitologia
[Mh] Termos MeSH secundário: Animais
Bioensaio
Coleópteros/crescimento & desenvolvimento
Ciclopropanos
DDT
Sinergismo Farmacológico
Hidrocarbonetos Fluorados
Larva
Dose Letal Mediana
Compostos Organotiofosforados
Butóxido de Piperonila
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclopropanes); 0 (Hydrocarbons, Fluorinated); 0 (Insecticides); 0 (Organothiophosphorus Compounds); 0 (Pyrethrins); 2HE8P42H2J (2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate); 6B66JED0KN (bifenthrin); CIW5S16655 (DDT); LWK91TU9AH (Piperonyl Butoxide); RN743HTX76 (merphos)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179311



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