Base de dados : MEDLINE
Pesquisa : D02.705.672.249 [Categoria DeCS]
Referências encontradas : 98 [refinar]
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[PMID]:27116696
[Au] Autor:Yoo CG; Pu Y; Li M; Ragauskas AJ
[Ad] Endereço:Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA.
[Ti] Título:Elucidating Structural Characteristics of Biomass using Solution-State 2 D NMR with a Mixture of Deuterated Dimethylsulfoxide and Hexamethylphosphoramide.
[So] Source:ChemSusChem;9(10):1090-5, 2016 05 23.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Recent developments of NMR methods for characterization of lignocellulosic biomass allow improved understanding of plant cell-wall structures with minimal deconstruction and modification of biomass. This study introduces a new NMR solvent system composed of dimethylsulfoxide (DMSO-d6 ) and hexamethylphosphoramide (HMPA-d18 ). HMPA as a co-solvent enhanced swelling and mobility of the biomass samples; thereby it allowed enhancing signals of NMR spectra. The structural information of biomass was successfully analyzed by the proposed NMR solvent system (DMSO-d6 /HMPA-d18 ; 4:1, v/v) with different biomass. The proposed bi-solvent system does not require derivatization or isolation of biomass, facilitating a facile sample preparation and involving with no signals overlapping with biomass peaks. It also allows analyzing biomass with a room-temperature NMR probe instead of cryo-probes, which are traditionally used for enhancing signal intensities.
[Mh] Termos MeSH primário: Biomassa
Deutério/química
Dimetil Sulfóxido/química
Hempa/química
[Mh] Termos MeSH secundário: Espectroscopia de Ressonância Magnética
Solventes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Solvents); AR09D82C7G (Deuterium); M42TU5843Z (Hempa); YOW8V9698H (Dimethyl Sulfoxide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160427
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201600135


  2 / 98 MEDLINE  
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[PMID]:25913631
[Au] Autor:Pant K; Roden N; Zhang C; Bruce S; Wood C; Pendino K
[Ad] Endereço:BioReliance by SAFC, Rockville, Maryland.
[Ti] Título:Modified in vivo comet assay detects the genotoxic potential of 14-hydroxycodeinone, an α,ß-unsaturated ketone in oxycodone.
[So] Source:Environ Mol Mutagen;56(9):777-87, 2015 Dec.
[Is] ISSN:1098-2280
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:14-Hydroxycodeinone (14-HC) is an α,ß-unsaturated ketone impurity found in oxycodone drug substance and has a structural alert for genotoxicity. 14-HC was tested in a combined Modified and Standard Comet Assay to determine if the slight decrease in % Tail DNA noted in a previously conducted Standard Comet Assay with 14-HC could be magnified to clarify if the response was due to cross-linking activity. One limitation of the Standard Comet Assay is that DNA cross-links cannot be reliably detected. However, under certain modified testing conditions, DNA cross-links and chemical moieties that elicit such cross-links can be elucidated. One such modification involves the induction of additional breakages of DNA strands by gamma or X-ray irradiation. To determine if 14-HC is a DNA crosslinker in vivo, a Modified Comet Assay was conducted using X-ray irradiation as the modification to visualize crosslinking activity. In this assay, 14-HC was administered orally to mice up to 320 mg/kg/day. Results showed a statistically significant reduction in percent tail DNA in duodenal cells at 320 mg/kg/day, with a nonstatistically significant but dose-related reduction in percent tail DNA also observed at the mid dose of 160 mg/kg/day. Similar decreases were not observed in cells from the liver or stomach, and no increases in percent tail DNA were noted for any tissue in the concomitantly conducted Standard Comet Assay. Taken together, 14-HC was identified as a cross-linking agent in the duodenum in the Modified Comet Assay.
[Mh] Termos MeSH primário: Ensaio Cometa/métodos
Oxicodona/análogos & derivados
[Mh] Termos MeSH secundário: Administração Oral
Animais
Clorambucila/toxicidade
Reagentes para Ligações Cruzadas/química
Reagentes para Ligações Cruzadas/toxicidade
Dano ao DNA/efeitos dos fármacos
Dano ao DNA/efeitos da radiação
Relação Dose-Resposta a Droga
Hempa/toxicidade
Fígado/efeitos dos fármacos
Fígado/efeitos da radiação
Masculino
Camundongos Endogâmicos ICR
Mitomicina/química
Mitomicina/toxicidade
Oxicodona/administração & dosagem
Oxicodona/química
Oxicodona/toxicidade
Estômago/efeitos dos fármacos
Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cross-Linking Reagents); 18D0SL7309 (Chlorambucil); 50SG953SK6 (Mitomycin); 91138F771G (hydroxycodeinone); CD35PMG570 (Oxycodone); M42TU5843Z (Hempa)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:151106
[Lr] Data última revisão:
151106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150428
[St] Status:MEDLINE
[do] DOI:10.1002/em.21957


  3 / 98 MEDLINE  
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[PMID]:25072695
[Au] Autor:Iwasaki H; Suzuki K; Yamane M; Yoshida S; Kojima N; Ozeki M; Yamashita M
[Ad] Endereço:Kyoto Pharmaceutical University, 1 Misasagi-Shichono, Yamashina, Kyoto 607-8412, Japan. yamasita@mb.kyoto-phu.ac.jp.
[Ti] Título:Indole synthesis from N-allenyl-2-iodoanilines under mild conditions mediated by samarium(II) diiodide.
[So] Source:Org Biomol Chem;12(35):6812-5, 2014 Sep 21.
[Is] ISSN:1477-0539
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel method for indole skeleton synthesis under mild conditions mediated by samarium(ii) diiodide has been developed. The reaction of N-allenyl-2-iodoaniline derivatives with SmI2 in the presence of HMPA and i-PrOH at 0 °C afforded indole derivatives in high yields.
[Mh] Termos MeSH primário: Compostos de Anilina/química
Química Orgânica/métodos
Indóis/química
Indóis/síntese química
Iodetos/química
Samário/química
[Mh] Termos MeSH secundário: Ciclização
Elétrons
Hempa/química
Modelos Químicos
Estrutura Molecular
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (2-iodobenzenamine); 0 (Aniline Compounds); 0 (Indoles); 0 (Iodides); 0 (samarium diiodide); 42OD65L39F (Samarium); M42TU5843Z (Hempa)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:140813
[Lr] Data última revisão:
140813
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140730
[St] Status:MEDLINE
[do] DOI:10.1039/c4ob01164c


  4 / 98 MEDLINE  
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[PMID]:24561966
[Au] Autor:Watermann T; Elgabarty H; Sebastiani D
[Ad] Endereço:Institute of Chemistry, Martin Luther University Halle-Wittenberg, Von-Danckelmann-Platz 4, 06120 Halle (Saale), Germany. daniel.sebastiani@chemie.uni-halle.de.
[Ti] Título:Phycocyanobilin in solution--a solvent triggered molecular switch.
[So] Source:Phys Chem Chem Phys;16(13):6146-52, 2014 Apr 07.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We present a computational investigation of the conformational response of phycocyanobilin (PCB) to the ability of solvents to form hydrogen bonds. PCB is the chromophore of several proteins in light harvesting complexes. We determine the conformational distributions in different solvents (methanol and hexamethylphosphoramide HMPT) by means of ab initio molecular dynamics simulations and characterize them via ab initio calculations of NMR chemical shift patterns. The computed trajectories and spectroscopic fingerprints illustrate that the energy landscape is very complex and exhibits various conformations of similar energy. We elucidate the strong influence of the solvent characteristics on the structural and spectroscopic parameters. Specifically, we predict a cis-trans isomerization of phycocyanobilin upon switching from the aprotic to the protic solvent, which explains an experimentally observed change in the NMR patterns. In the context of technological molecular recognition, solvent induced conformational switching can be considered a precursor mechanism to the recognition of single molecules.
[Mh] Termos MeSH primário: Hempa/química
Metanol/química
Ficobilinas/química
Ficocianina/química
[Mh] Termos MeSH secundário: Ligações de Hidrogênio
Isomerismo
Espectroscopia de Ressonância Magnética
Soluções/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Phycobilins); 0 (Solutions); 11016-15-2 (Phycocyanin); 36NUT04V2K (phycocyanobilin); M42TU5843Z (Hempa); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140225
[St] Status:MEDLINE
[do] DOI:10.1039/c3cp54307b


  5 / 98 MEDLINE  
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[PMID]:23654209
[Au] Autor:Lejeune C; Tian H; Appenzeller J; Ermolenko L; Martin MT; Al-Mourabit A
[Ad] Endereço:Institut de Chimie des Substances Naturelles, UPR 2301, Centre de Recherches de Gif-sur-Yvette, Avenue de la Terrasse, Gif-sur-Yvette, France.
[Ti] Título:Unprecedented biomimetic homodimerization of oroidin and clathrodin marine metabolites in the presence of HMPA or phosphonate salt tweezers.
[So] Source:J Nat Prod;76(5):903-8, 2013 May 24.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The first biomimetic homodimerization of oroidin and clathrodin was effected in the presence HMPA and diphosphonate salts, strong guanidinium and amide chelating agents. The intermolecular associations probably interfere with the entropically and kinetically favored intramolecular cyclizations. Use of oroidin·(1)/2HCl salt or clathrodin·(1)/2HCl was indicative in the presence of the ambident nucleophilic and electrophilic tautomers of the 2-aminoimidazolic oroidin and clathrodin precursors. Surprisingly, the homodimerization of oroidin led to the nagelamide D skeleton, while the homodimerization of clathrodin gave the benzene para-symmetrical structure 19. The common process was rationalized from tautomeric precursors I and III.
[Mh] Termos MeSH primário: Hempa/química
Imidazóis/química
Pirróis/química
[Mh] Termos MeSH secundário: Ciclização
Biologia Marinha
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Imidazoles); 0 (Pyrroles); 0 (nagelamide D); 135383-64-1 (clathrodin); M42TU5843Z (Hempa); PF75E92XKM (oroidin)
[Em] Mês de entrada:1308
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130510
[St] Status:MEDLINE
[do] DOI:10.1021/np400048r


  6 / 98 MEDLINE  
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[PMID]:23583600
[Au] Autor:Ermolovich YV; Zhabinskii VN; Khripach VA
[Ad] Endereço:Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich Str. 5/2, 220141 Minsk, Belarus.
[Ti] Título:1,4-Chirality transfer via the ester enolate Claisen rearrangements in the preparation of (25R)- and (25S)-cholestenoic acids.
[So] Source:Steroids;78(7):683-92, 2013 Jul.
[Is] ISSN:1878-5867
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two variants of the Claisen rearrangement were evaluated for a stereoselective construction of a C-25 stereogenic center in cholestenoic acids based on 1,4-chirality transfer. Johnson orthoester Claisen rearrangement of (22R)- and (22S)-propargyl enol ethers proceeded in a highly stereoselective manner to give (25R)- and (25S)-isomeric allenes. The stereochemical outcome of the Ireland-Claisen rearrangement of 22-allylic alcohols was dependent on the configuration of the C-22 hydroxyl group and the geometry of the enol ether. The latter could be controlled by the solvent (THF or a mixture of THF/HMPA) chosen for the generation of silyl enolate.
[Mh] Termos MeSH primário: Colestenos/química
[Mh] Termos MeSH secundário: 4-Aminopiridina/análogos & derivados
4-Aminopiridina/química
Hempa/química
Estrutura Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cholestenes); 0 (cholestenoic acid); BH3B64OKL9 (4-Aminopyridine); M42TU5843Z (Hempa); PFP1R6P0S8 (4-dimethylaminopyridine)
[Em] Mês de entrada:1312
[Cu] Atualização por classe:130528
[Lr] Data última revisão:
130528
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130416
[St] Status:MEDLINE


  7 / 98 MEDLINE  
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[PMID]:23407417
[Au] Autor:Sadasivam DV; Choquette KA; Flowers RA
[Ad] Endereço:Department of Chemistry, Lehigh University, PA, USA.
[Ti] Título:Preparation and use of samarium diiodide (SmI(2)) in organic synthesis: the mechanistic role of HMPA and Ni(II) salts in the samarium Barbier reaction.
[So] Source:J Vis Exp;(72):e4323, 2013 Feb 04.
[Is] ISSN:1940-087X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although initially considered an esoteric reagent, SmI(2) has become a common tool for synthetic organic chemists. SmI(2) is generated through the addition of molecular iodine to samarium metal in THF.(1,2-3) It is a mild and selective single electron reductant and its versatility is a result of its ability to initiate a wide range of reductions including C-C bond-forming and cascade or sequential reactions. SmI(2) can reduce a variety of functional groups including sulfoxides and sulfones, phosphine oxides, epoxides, alkyl and aryl halides, carbonyls, and conjugated double bonds.(2-12) One of the fascinating features of SmI-(2)-mediated reactions is the ability to manipulate the outcome of reactions through the selective use of cosolvents or additives. In most instances, additives are essential in controlling the rate of reduction and the chemo- or stereoselectivity of reactions.(13-14) Additives commonly utilized to fine tune the reactivity of SmI(2) can be classified into three major groups: (1) Lewis bases (HMPA, other electron-donor ligands, chelating ethers, etc.), (2) proton sources (alcohols, water etc.), and (3) inorganic additives (Ni(acac)(2), FeCl(3), etc).(3) Understanding the mechanism of SmI(2) reactions and the role of the additives enables utilization of the full potential of the reagent in organic synthesis. The Sm-Barbier reaction is chosen to illustrate the synthetic importance and mechanistic role of two common additives: HMPA and Ni(II) in this reaction. The Sm-Barbier reaction is similar to the traditional Grignard reaction with the only difference being that the alkyl halide, carbonyl, and Sm reductant are mixed simultaneously in one pot.(1,15) Examples of Sm-mediated Barbier reactions with a range of coupling partners have been reported,(1,3,7,10,12) and have been utilized in key steps of the synthesis of large natural products.(16,17) Previous studies on the effect of additives on SmI(2) reactions have shown that HMPA enhances the reduction potential of SmI(2) by coordinating to the samarium metal center, producing a more powerful,(13-14,18) sterically encumbered reductant(19-21) and in some cases playing an integral role in post electron-transfer steps facilitating subsequent bond-forming events.(22) In the Sm-Barbier reaction, HMPA has been shown to additionally activate the alkyl halide by forming a complex in a pre-equilibrium step.(23) Ni(II) salts are a catalytic additive used frequently in Sm-mediated transformations.(24-27) Though critical for success, the mechanistic role of Ni(II) was not known in these reactions. Recently it has been shown that SmI(2) reduces Ni(II) to Ni(0), and the reaction is then carried out through organometallic Ni(0) chemistry.(28) These mechanistic studies highlight that although the same Barbier product is obtained, the use of different additives in the SmI(2) reaction drastically alters the mechanistic pathway of the reaction. The protocol for running these SmI(2)-initiated reactions is described.
[Mh] Termos MeSH primário: Técnicas de Química Sintética/métodos
Hempa/química
Iodetos/química
Níquel/química
Samário/química
[Mh] Termos MeSH secundário: Acetatos/química
Cátions Bivalentes/química
Iodetos/síntese química
Compostos Organometálicos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; VIDEO-AUDIO MEDIA
[Nm] Nome de substância:
0 (Acetates); 0 (Cations, Divalent); 0 (Iodides); 0 (Organometallic Compounds); 0 (samarium diiodide); 42OD65L39F (Samarium); 7OV03QG267 (Nickel); 99QP4ELX96 (nickel acetate); M42TU5843Z (Hempa)
[Em] Mês de entrada:1305
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130215
[St] Status:MEDLINE


  8 / 98 MEDLINE  
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[PMID]:23025345
[Au] Autor:Rao CN; Hoz S
[Ad] Endereço:Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel.
[Ti] Título:Synergism and inhibition in the combination of visible light and HMPA in SmI2 reductions.
[So] Source:J Org Chem;77(20):9199-204, 2012 Oct 19.
[Is] ISSN:1520-6904
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The reaction of six substrates (diphenylacetylene, benzonitrile, methyl benzoate, phenylacetylene, naphthalene, and 1-chloro-4-ethylbenzene) with SmI(2) in the presence of MeOH or TFE was studied. The reactions were monitored under three different conditions: (a) irradiation, (b) irradiation in the presence of HMPA, and (c) reactions in the presence of HMPA in the dark. The combination of visible light and HMPA was found in some cases to be synergistic, in others to be additive, and in four cases to be inhibitive. The Marcus theory provides a good understanding of the synergistic and the additivity phenomena. The inhibitive effect is traced to the post electron transfer step in which Sm(3+) plays an important role. Once coordinated to HMPA, Sm(3+) is less capable of assisting in the protonation of the radical anion or the expulsion of the leaving group. Ranking according to the substrate's electron affinity shows that inhibition is manifested for the three least electrophilic substrates: phenylacetylene, naphthalene, and 1-chloro-4-ethylbenzene. Typical of these substrates is the short lifetime of their radical anions. Thus, if a step consecutive to electron transfer is slow and cannot compete successfully with the rapid back electron transfer, the benefit of having the electron transfer step enhanced is much reduced.
[Mh] Termos MeSH primário: Hempa/química
Iodetos/química
Luz
Samário/química
[Mh] Termos MeSH secundário: Acetileno/análogos & derivados
Acetileno/química
Benzoatos/química
Estrutura Molecular
Naftalenos/química
Nitrilos/química
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoates); 0 (Iodides); 0 (Naphthalenes); 0 (Nitriles); 0 (samarium diiodide); 2166IN72UN (naphthalene); 239WSR2IBO (phenylacetylene); 42OD65L39F (Samarium); 501-65-5 (biphenylacetylene); 6618K1VJ9T (methyl benzoate); 9V9APP5H5S (benzonitrile); M42TU5843Z (Hempa); OC7TV75O83 (Acetylene)
[Em] Mês de entrada:1303
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121003
[St] Status:MEDLINE
[do] DOI:10.1021/jo3017814


  9 / 98 MEDLINE  
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[PMID]:22492203
[Au] Autor:Doherty AT; Hayes J; Holme P; O'Donovan M
[Ad] Endereço:Safety Assessment and DMPK Department, AstraZeneca R&D, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK. ann.doherty@astrazeneca.com
[Ti] Título:Chromosome aberration frequency in rat peripheral lymphocytes increases with repeated dosing with hexamethylphosphoramide or cyclophosphamide.
[So] Source:Mutagenesis;27(5):533-9, 2012 Sep.
[Is] ISSN:1464-3804
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although there are several in vivo tests for potential genotoxicity, with the possible exception of the transgenic rodent mutation models, none is specifically intended to assess increasing damage with chronic administration. In principle, peripheral blood lymphocytes would be expected to accumulate DNA damage with repeated dosing because the majority are not in active division and appear to have limited DNA repair capability, and they are exposed to plasma levels of test materials and metabolites. However, there appear to be no published reports confirming this principle. Therefore, in the current study, after optimising culture conditions for rat lymphocytes in this laboratory, rats were given oral doses of cyclophosphamide or hexamethylphosphoramide (HMPA) for up to 28 days and peripheral lymphocytes analysed for chromosome aberrations at various time points. The results clearly show that, for both compounds, doses that gave no significant increases in aberration frequency after 2 days induced clear increases after 15 days with further damage detectable after 28 doses. With HMPA, it was shown that DNA damage persisted for at least 10 days after cessation of treatment. These data show that repeat dose studies in the rat measuring chromosome aberration frequency in lymphocytes can give a genuine indication that genotoxicity may increase with chronic administration and, therefore, maybe useful in assessing the risk of potentially genotoxic substances.
[Mh] Termos MeSH primário: Aberrações Cromossômicas/induzido quimicamente
Ciclofosfamida/toxicidade
Hempa/toxicidade
Linfócitos/efeitos dos fármacos
Mutagênicos/toxicidade
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Ciclofosfamida/administração & dosagem
Ciclofosfamida/farmacologia
Hempa/administração & dosagem
Hempa/farmacologia
Linfócitos/metabolismo
Masculino
Testes de Mutagenicidade
Mutagênicos/administração & dosagem
Mutagênicos/farmacologia
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Mutagens); 8N3DW7272P (Cyclophosphamide); M42TU5843Z (Hempa)
[Em] Mês de entrada:1301
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120412
[St] Status:MEDLINE
[do] DOI:10.1093/mutage/ges016


  10 / 98 MEDLINE  
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[PMID]:21852847
[Au] Autor:National Toxicology Program
[Ti] Título:Hexamethylphosphoramide.
[So] Source:Rep Carcinog;12:229-31, 2011.
[Is] ISSN:1551-8280
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Carcinógenos/toxicidade
Hempa/toxicidade
[Mh] Termos MeSH secundário: Animais
Esterilizantes Químicos/toxicidade
Dimetilaminas/toxicidade
Regulamentação Governamental
Seres Humanos
Exposição Ocupacional
Solventes/toxicidade
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinogens); 0 (Chemosterilants); 0 (Dimethylamines); 0 (Solvents); M42TU5843Z (Hempa)
[Em] Mês de entrada:1202
[Cu] Atualização por classe:161021
[Lr] Data última revisão:
161021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110820
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde