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Pesquisa : D02.715.650.700.150 [Categoria DeCS]
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  1 / 4703 MEDLINE  
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[PMID]:29232610
[Au] Autor:Sadeghi S; Mollahosseini A
[Ad] Endereço:Research Laboratory of Spectroscopy & Micro and Nano Extraction, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran.
[Ti] Título:Electrospun polydimethylsiloxane/polyacrylonitrile/titanium dioxide nanofibers as a new coating for determination of alpha-linolenic acid in milk by direct immersion-solid phase nanoextraction.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1073:43-50, 2018 Jan 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this study, polydimethylsiloxane/polyacrylonitrile/titanium dioxide (PDMS/PAN/TiO ) nanofibers were synthesized via electrospinning method to extract and quantify alpha-linolenic acid (ALA, C18:3), as a model analyte, in milk by direct immersion-solid phase nanoextraction (DI-SPNE) with gas chromatography-flame ionization detector (GC-FID). The affecting factors on the electrospinning process such as, PDMS concentration, amount of TiO nanoparticles (NPs), voltage, and electrospinning distance were optimized using Taguchi's orthogonal design. The SPNE experimental conditions such as, extraction time, agitation rate, pH and salt concentration, were also optimized using response surface methodology (RSM) based on a central composite design (CCD). Under optimized conditions, the resulting calibration curve was linear in the range of 1-4000ngmL with R =0.998. The intraday, interday, and fiber-to-fiber repeatability were calculated and the corresponding relative standard deviation was less than 9% in all the cases. The limit of detection and limit of quantification were found to be 0.2 and 0.6ngmL , respectively. Omega-3 enriched milk was used as a real sample and the value of relative recoveries were measured to be in the range of 92-106%.
[Mh] Termos MeSH primário: Leite/química
Nanofibras/química
Nanotecnologia/métodos
Microextração em Fase Sólida/métodos
Ácido alfa-Linolênico/análise
[Mh] Termos MeSH secundário: Resinas Acrílicas
Animais
Dimetilpolisiloxanos
Técnicas Eletroquímicas
Limite de Detecção
Modelos Lineares
Reprodutibilidade dos Testes
Titânio
Ácido alfa-Linolênico/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Dimethylpolysiloxanes); 0RBV727H71 (alpha-Linolenic Acid); 15FIX9V2JP (titanium dioxide); 25014-41-9 (polyacrylonitrile); D1JT611TNE (Titanium)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE


  2 / 4703 MEDLINE  
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[PMID]:28747398
[Au] Autor:Leivo J; Virjula S; Vanhatupa S; Kartasalo K; Kreutzer J; Miettinen S; Kallio P
[Ad] Endereço:Micro- and Nanosystems Research Group, BioMediTech Institute and Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, Tampere, Finland.
[Ti] Título:A durable and biocompatible ascorbic acid-based covalent coating method of polydimethylsiloxane for dynamic cell culture.
[So] Source:J R Soc Interface;14(132), 2017 Jul.
[Is] ISSN:1742-5662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Polydimethylsiloxane (PDMS) is widely used in dynamic biological microfluidic applications. As a highly hydrophobic material, native PDMS does not support cell attachment and culture, especially in dynamic conditions. Previous covalent coating methods use glutaraldehyde (GA) which, however, is cytotoxic. This paper introduces a novel and simple method for binding collagen type I covalently on PDMS using ascorbic acid (AA) as a cross-linker instead of GA. We compare the novel method against physisorption and GA cross-linker-based methods. The coatings are characterized by immunostaining, contact angle measurement, atomic force microscopy and infrared spectroscopy, and evaluated in static and stretched human adipose stem cell (hASC) cultures up to 13 days. We found that AA can replace GA as a cross-linker in the covalent coating method and that the coating is durable after sonication and after 6 days of stretching. Furthermore, we show that hASCs attach and proliferate better on AA cross-linked samples compared with physisorbed or GA-based methods. Thus, in this paper, we provide a new PDMS coating method for studying cells, such as hASCs, in static and dynamic conditions. The proposed method is an important step in the development of PDMS-based devices in cell and tissue engineering applications.
[Mh] Termos MeSH primário: Ácido Ascórbico/química
Materiais Revestidos Biocompatíveis/química
Dimetilpolisiloxanos/química
Células Mesenquimais Estromais/fisiologia
Técnicas Analíticas Microfluídicas/instrumentação
[Mh] Termos MeSH secundário: Adesão Celular
Técnicas de Cultura de Células
Proliferação Celular
Sobrevivência Celular
Seres Humanos
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coated Materials, Biocompatible); 0 (Dimethylpolysiloxanes); 63148-62-9 (baysilon); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE


  3 / 4703 MEDLINE  
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[PMID]:29289295
[Au] Autor:Chung IY; Park YM; Lee HJ; Kim H; Kim DH; Kim IG; Kim SM; Do YS; Seok KS; Kwon JH
[Ad] Endereço:Chemical Research Division, Environmental Health Research Department, National Institute of Environmental Research, Incheon 22689, Republic of Korea.
[Ti] Título:Nontarget screening using passive air and water sampling with a level II fugacity model to identify unregulated environmental contaminants.
[So] Source:J Environ Sci (China);62:84-91, 2017 Dec.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:It is thought that there are many unregulated anthropogenic chemicals in the environment. For risk assessment of chemicals, it is essential to estimate the predicted environmental concentrations. As an effort of identifying residual organic contaminants in air and water in Korea, nontarget screening using two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOFMS) was conducted at 10 sites using polyurethane foam passive air sampler and at 6 sites using polydimethyl siloxane (PDMS) passive water sampler in three different seasons in 2014. More than 600 chemical peaks were identified satisfying the identification criteria in air and water samples, respectively, providing a list for further investigation. Chemical substances with reported national emission rates in 2014 (n=149) were also screened for potential existence in the environment using a level II fugacity model. Most of chemical substances classified as not detectable were not identified with detection frequency greater than 20% by nontarget screening, indicating that a simple equilibrium model has a strong potential to be used to exclude chemicals that are not likely to remain in the environment after emissions from targeted monitoring.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/análise
Monitoramento Ambiental/métodos
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Dimetilpolisiloxanos/análise
República da Coreia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Dimethylpolysiloxanes); 0 (Water Pollutants, Chemical); 63148-62-9 (baysilon)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180103
[Lr] Data última revisão:
180103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180101
[St] Status:MEDLINE


  4 / 4703 MEDLINE  
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[PMID]:28451924
[Au] Autor:Shim KY; Lee D; Han J; Nguyen NT; Park S; Sung JH
[Ad] Endereço:Department of Chemical Engineering, Hongik University, Seoul, South Korea.
[Ti] Título:Microfluidic gut-on-a-chip with three-dimensional villi structure.
[So] Source:Biomed Microdevices;19(2):37, 2017 Jun.
[Is] ISSN:1572-8781
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Current in vitro gut models lack physiological relevance, and various approaches have been taken to improve current cell culture models. For example, mimicking the three-dimensional (3D) tissue structure or fluidic environment has been shown to improve the physiological function of gut cells. Here, we incorporated a collagen scaffold that mimics the human intestinal villi into a microfluidic device, thus providing cells with both 3D tissue structure and fluidic shear. We hypothesized that the combined effect of 3D structure and fluidic shear may provide cells with adequate stimulus to induce further differentiation and improve physiological relevance. The physiological function of our '3D gut chip' was assessed by measuring the absorptive permeability of the gut epithelium and activity of representative enzymes, as well as morphological evaluation. Our results suggest that the combination of fluidic stimulus and 3D structure induces further improvement in gut functions. Our work provides insight into the effect of different tissue environment on gut cells.
[Mh] Termos MeSH primário: Intestinos/citologia
Dispositivos Lab-On-A-Chip
[Mh] Termos MeSH secundário: Células CACO-2
Colágeno/química
Dimetilpolisiloxanos/química
Seres Humanos
Intestinos/metabolismo
Membranas Artificiais
Permeabilidade
Porosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dimethylpolysiloxanes); 0 (Membranes, Artificial); 63148-62-9 (baysilon); 9007-34-5 (Collagen)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171225
[Lr] Data última revisão:
171225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s10544-017-0179-y


  5 / 4703 MEDLINE  
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[PMID]:28465106
[Au] Autor:Santini GC; Potrich C; Lunelli L; Vanzetti L; Marasso SL; Cocuzza M; Pirri FC; Pederzolli C
[Ad] Endereço:Fondazione Bruno Kessler, Laboratory of Biomolecular Sequence and Structure Analysis for Health, Via Sommarive 18, 38123, Povo, Trento, Italy.
[Ti] Título:miRNA purification with an optimized PDMS microdevice: Toward the direct purification of low abundant circulating biomarkers.
[So] Source:Biophys Chem;229:142-150, 2017 10.
[Is] ISSN:1873-4200
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A reliable clinical assay based on circulating microRNAs (miRNAs) as biomarkers is highly required. Microdevices offer an attractive solution as a fast and inexpensive way of concentrating these biomarkers from a low sample volume. A previously developed polydimethylsiloxane (PDMS) microdevice able to purify and detect circulating miRNAs was here optimized. The optimization of the morphological and chemical surface properties by nanopatterning and functionalization is presented. Surfaces were firstly characterized by atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), fluorescamine assay and s-SDTB (sulphosuccinimidyl-4-o-(4,4-dimethoxytrityl) butyrate) assay and subsequently tested for their capacity to adsorb a fluorescent miRNA. From our analysis, modification of surface charge with 0.1% APTMS ((3-Aminopropyl)trimethoxysilane) and 0.9% PEG-s (2-[Methoxy-(polyethyleneoxy)propyl]trimethoxysilane) performed at 60°C for 10min was identified as the best purification condition. Our optimized microdevice integrated with real-time PCR detection, was demonstrated to selectively purify both synthetic and natural circulating miRNAs with a sensitivity of 0.01pM.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Dimetilpolisiloxanos/química
MicroRNAs/isolamento & purificação
Técnicas Analíticas Microfluídicas/métodos
[Mh] Termos MeSH secundário: Corantes Fluorescentes/química
Seres Humanos
Isocianatos/química
MicroRNAs/sangue
MicroRNAs/química
Técnicas Analíticas Microfluídicas/instrumentação
Microscopia de Força Atômica
Espectroscopia Fotoeletrônica
Reação em Cadeia da Polimerase em Tempo Real
Silanos/química
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (3-isocyanatopropyl trimethoxysilane); 0 (Biomarkers); 0 (Dimethylpolysiloxanes); 0 (Fluorescent Dyes); 0 (Isocyanates); 0 (MicroRNAs); 0 (Silanes); 63148-62-9 (baysilon)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  6 / 4703 MEDLINE  
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[PMID]:29049304
[Au] Autor:Lynch KJ; Skalli O; Sabri F
[Ad] Endereço:Dept. of Physics and Materials Science, University of Memphis, Memphis, Tennessee, United States of America.
[Ti] Título:Investigation of surface topography and stiffness on adhesion and neurites extension of PC12 cells on crosslinked silica aerogel substrates.
[So] Source:PLoS One;12(10):e0185978, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fundamental understanding and characterization of neural response to substrate topography is essential in the development of next generation biomaterials for nerve repair. Aerogels are a new class of materials with great potential as a biomaterial. In this work, we examine the extension of neurites by PC12 cells plated on matrigel-coated and collagen-coated mesoporous aerogel surfaces. We have successfully established the methodology for adhesion and growth of PC12 cells on polyurea crosslinked silica aerogels. Additionally, we have quantified neurite behaviors and compared their response on aerogel substrates with their behavior on tissue culture (TC) plastic, and polydimethylsiloxane (PDMS). We found that, on average, PC12 cells extend longer neurites on crosslinked silica aerogels than on tissue culture plastic, and, that the average number of neurites per cluster is lower on aerogels than on tissue culture plastic. Aerogels are an attractive candidate for future development of smart neural implants and the work presented here creates a platform for future work with this class of materials as a substrate for bioelectronic interfacing.
[Mh] Termos MeSH primário: Géis
Neuritos
Dióxido de Silício
[Mh] Termos MeSH secundário: Animais
Dimetilpolisiloxanos
Seres Humanos
Microscopia Eletrônica de Varredura
Células PC12
Plásticos
Ratos
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dimethylpolysiloxanes); 0 (Gels); 0 (Plastics); 63148-62-9 (baysilon); 7631-86-9 (Silicon Dioxide)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185978


  7 / 4703 MEDLINE  
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[PMID]:28859151
[Au] Autor:Chen N; Bai Y; Fan YL; Liu TX
[Ad] Endereço:State Key Laboratory of Crop Stress Biology for Arid Areas, and Key Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, China.
[Ti] Título:Solid-phase microextraction-based cuticular hydrocarbon profiling for intraspecific delimitation in Acyrthosiphon pisum.
[So] Source:PLoS One;12(8):e0184243, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Insect cuticular hydrocarbons (CHCs) play critical roles in reducing water loss and chemical communication. Species-specific CHC profiles have been used increasingly as an excellent character for species classification. However, considerably less is known about their potential for population delimitation within species. The aims of this study were to develop a solid-phase microextraction (SPME)-based CHC collection method and to investigate whether CHC profiles could serve as potential chemotaxonomic tools for intraspecific delimitation in Acyrthosiphon pisum. Optimization of fibers for SPME sampling revealed that 7 µm polydimethylsiloxane (PDMS) demonstrated the most efficient adsorption of CHCs among five different tested fibers. SPME sampling showed good reproducibility with repeated collections of CHCs from a single aphid. Validation of SPME was performed by comparing CHC profiles with those from conventional hexane extractions. The two methods showed no qualitative differences in CHCs, although SPME appeared to extract relatively fewer short-chained CHCs. While CHC profiles of a given population differed among developmental stages, wing dimorphism types, and host plants, wingless adult aphids showed very low variance in relative proportions of individual CHC components. Reproducibility of CHC profiles was explored further to classify wingless adult morphs of A. pisum from five different geographic regions that showed no variation in mitochondrial COI gene sequences. Our results demonstrate that CHC profiles are useful in intraspecific delimitation in the field of insect chemotaxonomy.
[Mh] Termos MeSH primário: Afídeos/classificação
Classificação
Hidrocarbonetos/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Afídeos/química
Dimetilpolisiloxanos/química
Cromatografia Gasosa-Espectrometria de Massas
Hidrocarbonetos/química
Hidrocarbonetos/classificação
Análise de Componente Principal
Microextração em Fase Sólida
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dimethylpolysiloxanes); 0 (Hydrocarbons); 63148-62-9 (baysilon)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184243


  8 / 4703 MEDLINE  
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[PMID]:28837583
[Au] Autor:An X; Sendra VG; Liadi I; Ramesh B; Romain G; Haymaker C; Martinez-Paniagua M; Lu Y; Radvanyi LG; Roysam B; Varadarajan N
[Ad] Endereço:Department of Chemical and Biomolecular Engineering, University of Houston, Houston, Texas, United States of America.
[Ti] Título:Single-cell profiling of dynamic cytokine secretion and the phenotype of immune cells.
[So] Source:PLoS One;12(8):e0181904, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Natural killer (NK) cells are a highly heterogeneous population of innate lymphocytes that constitute our first line of defense against several types of tumors and microbial infections. Understanding the heterogeneity of these lymphocytes requires the ability to integrate their underlying phenotype with dynamic functional behaviors. We have developed and validated a single-cell methodology that integrates cellular phenotyping and dynamic cytokine secretion based on nanowell arrays and bead-based molecular biosensors. We demonstrate the robust passivation of the polydimethylsiloxane (PDMS)-based nanowells arrays with polyethylene glycol (PEG) and validated our assay by comparison to enzyme-linked immunospot (ELISPOT) assays. We used numerical simulations to optimize the molecular density of antibodies on the surface of the beads as a function of the capture efficiency of cytokines within an open-well system. Analysis of hundreds of individual human peripheral blood NK cells profiled ex vivo revealed that CD56dimCD16+ NK cells are immediate secretors of interferon gamma (IFN-γ) upon activation by phorbol 12-myristate 13-acetate (PMA) and ionomycin (< 3 h), and that there was no evidence of cooperation between NK cells leading to either synergistic activation or faster IFN-γ secretion. Furthermore, we observed that both the amount and rate of IFN-γ secretion from individual NK cells were donor-dependent. Collectively, these results establish our methodology as an investigational tool for combining phenotyping and real-time protein secretion of individual cells in a high-throughput manner.
[Mh] Termos MeSH primário: Citocinas/secreção
Imunofenotipagem
Células Matadoras Naturais/imunologia
[Mh] Termos MeSH secundário: Antígeno CD56/imunologia
Dimetilpolisiloxanos
Ensaio de Imunoadsorção Enzimática
Proteínas Ligadas por GPI/imunologia
Seres Humanos
Células Matadoras Naturais/efeitos dos fármacos
Receptores de IgG/imunologia
Análise de Célula Única
Acetato de Tetradecanoilforbol/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CD56 Antigen); 0 (Cytokines); 0 (Dimethylpolysiloxanes); 0 (FCGR3B protein, human); 0 (GPI-Linked Proteins); 0 (NCAM1 protein, human); 0 (Receptors, IgG); 63148-62-9 (baysilon); NI40JAQ945 (Tetradecanoylphorbol Acetate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181904


  9 / 4703 MEDLINE  
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[PMID]:28832718
[Au] Autor:Camargo RV; Silva-Sousa YTC; Rosa RPFD; Mazzi-Chaves JF; Lopes FC; Steier L; Sousa-Neto MD
[Ad] Endereço:Universidade de São Paulo - USP, School of Dentistry of Ribeirão Preto, Department of Restorative Dentistry, Ribeirão Preto, SP, Brazil.
[Ti] Título:Evaluation of the physicochemical properties of silicone- and epoxy resin-based root canal sealers.
[So] Source:Braz Oral Res;31:e72, 2017 Aug 21.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:To assess the physicochemical properties of AH Plus, GuttaFlow 2, GuttaFlow BioSeal, and MM Seal, five samples of each root canal sealer were evaluated to determine their setting time (ST), dimensional change (DC), solubility (SL), flow (FL), and radiopacity (RD) according to American National Standards Institute/American Dental Association (ANSI/ADA) Specification 57. The distilled and deionized water obtained from the SL test were subjected to atomic absorption spectrometry to observe the presence of Ca2+, K+, and Na+ ions. Statistical analysis was performed by using one-way ANOVA and Tukey-Kramer tests (p < 0.05). The following results were obtained: ST (min) (AH Plus 463.6 ± 13.22; GuttaFlow 2 24.35 ± 2.78; GuttaFlow Bioseal 17.4 ± 0.55; MM Seal 47.60 ± 4.39), DC (%) (AH Plus 0.06 ± 0.12; GuttaFlow 2 -26.06 ± 1.24; GuttaFlow Bioseal 2.10 ± 1.47; MM Seal 8.47 ± 2.41), SL (%) (AH Plus 0.41 ± 0.21; GuttaFlow 2 5.13 ± 4.11; GuttaFlow Bioseal 3.03 ± 1.05; MM Seal 0.94 ± 0.17), FL (mm) (AH Plus 36.42 ± 0.40; GuttaFlow 2 36.44 ± 0.05; GuttaFlow Bioseal 35.4 ± 0.03; MM Seal 52.75 ± 0.60), and RD (mmAl) (AH Plus 7.52 ± 1.59; GuttaFlow 2 6.85 ± 0.14; GuttaFlow Bioseal 7.02 ± 0.18; MM Seal 3.32 ± 0.90). ST, DC, SL, FL, and RD showed statistical differences among the root canal sealers (p < 0.05). As AH Plus showed the lowest DC and SL values (p < 0.05), the findings indicate that this sample is the only sealer conforming to ANSI/ADA standards.
[Mh] Termos MeSH primário: Dimetilpolisiloxanos/química
Resinas Epóxi/química
Guta-Percha/química
Materiais Restauradores do Canal Radicular/química
Silicones/química
[Mh] Termos MeSH secundário: Análise de Variância
Combinação de Medicamentos
Teste de Materiais
Valores de Referência
Solubilidade
Espectrofotometria Atômica
Estatísticas não Paramétricas
Propriedades de Superfície
Fatores de Tempo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bioseal); 0 (Dimethylpolysiloxanes); 0 (Drug Combinations); 0 (Epoxy Resins); 0 (GuttaFlow); 0 (Root Canal Filling Materials); 0 (Silicones); 0 (epoxy resin-based root canal sealer); 9000-32-2 (Gutta-Percha)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE


  10 / 4703 MEDLINE  
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[PMID]:28791811
[Au] Autor:Pawinska M; Szczurko G; Kierklo A; Sidun J
[Ad] Endereço:Department of Conservative Dentistry, Medical University of Bialystok, Poland.
[Ti] Título:A laboratory study evaluating the pH of various modern root canal filling materials.
[So] Source:Adv Clin Exp Med;26(3):387-392, 2017 May-Jun.
[Is] ISSN:1899-5276
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Alkaline pH is responsible for antibacterial activity and the stimulation of periapical tissue healing. It neutralizes the acidic environment of inflammatory tissues in the periapical region of the teeth and favors bone repair by activating tissue enzymes. OBJECTIVES: The aim of this study was to evaluate and compare in vitro the pH of 8 root canal filling materials (sealers and points) -AH Plus Jet (AH), Apexit Plus (AP), Endomethasone N (END), Epiphany (EP), GuttaFlow (GF), gutta-percha (G), Resilon (R), Tubliseal (T). MATERIAL AND METHODS: 0.1 g of each material (n = 6) was placed in dialysis tubes and immersed in 20 mL of deionized water. The control contained deionized water (pH 6.6) with an empty tube. The pH values were recorded immediately after immersion (baseline) and after 1, 2, 24, 48, 120, and 192 h with a pH-meter. Data were statistically analyzed using the Student's -t test and 1-way analysis of variance (p < 0.05). RESULTS: Nearly all the materials had pH significantly higher than the control (p < 0.05). There were significant differences in the pH between the materials tested at each time point (p < 0.001). The highest pH was exhibited by EP, followed by AP and AH. The lowest pH was shown by GF, G and R. CONCLUSIONS: Among the materials studied, only EP, AP and AH Plus were able to elevate the pH level that would allow inactivation of microorganisms in the root canals and promote healing of inflamed periapical tissues. However, the low alkalizing potential of G and R can be modified by the concomitant application of sealers producing alkaline pH.
[Mh] Termos MeSH primário: Materiais Restauradores do Canal Radicular/química
[Mh] Termos MeSH secundário: Hidróxido de Cálcio/química
Dimetilpolisiloxanos/química
Combinação de Medicamentos
Guta-Percha/química
Seres Humanos
Concentração de Íons de Hidrogênio
Teste de Materiais/métodos
Diálise Renal/métodos
Cimento de Óxido de Zinco e Eugenol/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Apexit); 0 (Dimethylpolysiloxanes); 0 (Drug Combinations); 0 (GuttaFlow); 0 (Root Canal Filling Materials); 0 (Zinc Oxide-Eugenol Cement); 69234-22-6 (tubliseal); 9000-32-2 (Gutta-Percha); PF5DZW74VN (Calcium Hydroxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.17219/acem/60440



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