Base de dados : MEDLINE
Pesquisa : D02.806.250.210 [Categoria DeCS]
Referências encontradas : 154 [refinar]
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[PMID]:28238930
[Au] Autor:Fu J; Xia X; Liu Z; Wang Y; Wang Y; Shi Q; Song X; Song E; Song Y
[Ad] Endereço:Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, People's Republic of China.
[Ti] Título:The acute exposure of tetrachloro-p-benzoquinone (a.k.a. chloranil) triggers inflammation and neurological dysfunction via Toll-like receptor 4 signaling: The protective role of melatonin preconditioning.
[So] Source:Toxicology;381:39-50, 2017 Apr 15.
[Is] ISSN:1879-3185
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:This study is aimed to investigate the inflammation and neurological dysfunction induced by tetrachloro-p-benzoquinone (TCBQ) through Toll-like receptor 4 (TLR4) signaling. We also investigated the protective role of melatonin as an antioxidant and anti-inflammatory agent. In vitro model was established by rat pheochromocytoma PC12 cells, meanwhile, TLR4 wild-type (C57BL/6) and knockout mice (C57BL/10ScNJ TLR4 ) were used as in vivo model. In vitro study showed TCBQ exposure enhanced the expression of TLR4, myeloid differentiation factor 88 (MyD88) at both transcriptional and post-transcriptional levels. By contrast, melatonin decreased TLR4 and MyD88 expressions. Moreover, our result indicated that melatonin disrupted the formation of TLR4/MyD88/MD2/CD14 complex. In addition, melatonin terminated TCBQ-mediated phosphorylation of c-Jun N-terminal kinase (JNK), p38, and extracellular regulated protein kinase (ERK) signaling and hampered its downstream pro-inflammatory cytokine releases. In vivo result also indicated TLR4 deficiency partially protected against TCBQ-induced morphological and neuropathological changes in mice brain, suggested the role of TLR4. In conclusion, melatonin modulates TCBQ-mediated inflammatory genes through TLR4/MyD88-dependent signaling pathway. Our current study, to the best of our knowledge, is the first time show melatonin not only disrupt the binding of TLR4 and MyD88, but also restricted the formation of TLR4/MD2/CD14 complex, suggesting that melatonin supplementary may represent a valuable therapeutic strategy for inflammatory neurological dysfunction.
[Mh] Termos MeSH primário: Cloranila/toxicidade
Inflamação/tratamento farmacológico
Melatonina/farmacologia
Doenças do Sistema Nervoso/tratamento farmacológico
Receptor 4 Toll-Like/metabolismo
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/farmacologia
Modelos Animais de Doenças
MAP Quinases Reguladas por Sinal Extracelular/genética
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Regulação da Expressão Gênica
Inflamação/induzido quimicamente
Inflamação/patologia
Proteínas Quinases JNK Ativadas por Mitógeno/genética
Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo
Receptores de Lipopolissacarídeos/genética
Receptores de Lipopolissacarídeos/metabolismo
Antígeno 96 de Linfócito/genética
Antígeno 96 de Linfócito/metabolismo
Sistema de Sinalização das MAP Quinases
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Fator 88 de Diferenciação Mieloide/genética
Fator 88 de Diferenciação Mieloide/metabolismo
Doenças do Sistema Nervoso/induzido quimicamente
Fosforilação
Transdução de Sinais
Receptor 4 Toll-Like/deficiência
Receptor 4 Toll-Like/genética
Testes de Toxicidade Aguda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Lipopolysaccharide Receptors); 0 (Ly96 protein, mouse); 0 (Lymphocyte Antigen 96); 0 (Myd88 protein, mouse); 0 (Myeloid Differentiation Factor 88); 0 (Tlr4 protein, mouse); 0 (Toll-Like Receptor 4); 01W5X7N5XV (Chloranil); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases); JL5DK93RCL (Melatonin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170228
[St] Status:MEDLINE


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[PMID]:28115151
[Au] Autor:Li C; Wang F; Wang H
[Ad] Endereço:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Electronic address: licuiping198585@126.com.
[Ti] Título:Tetrachloro-1,4-benzoquinone induces apoptosis of mouse embryonic stem cells.
[So] Source:J Environ Sci (China);51:5-12, 2017 Jan.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Pentachlorophenol (PCP) is a widespread, persistent environmental contaminant, and it is enzymatically activated to form a reactive metabolite, tetrachloro-1,4-benzoquinone (TCBQ). To our knowledge, there is no information about TCBQ toxicity on embryonic stem cells. Here, we demonstrated that TCBQ induced significantly apoptosis of mouse embryonic stem cells in a concentration-dependent manner. We also showed that TCBQ elevated genomic 5-hydroxymethylcytosine (5hmC) by affecting ten-eleven translocation (Tet) dioxygenases in mouse embryonic stem cells. We further investigated whether Tet dioxygenases were implicated in TCBQ-induced apoptosis. By depleting all three dioxygenases (Tet1-3), we found that Tet dioxygenases slightly inhibited both early and late apoptosis induced by TCBQ at a low concentration (30µmol/L). Meanwhile, treated by TCBQ at higher concentrations (40 and 50µmol/L), the total percentage of apoptotic cells was not affected by Tet dioxygenases. However, Tet dioxygenases tended to arrest mouse ES cells to be at early apoptotic stage and to reduce the cells to enter later apoptotic stage. These results indicate that Tet dioxygenases play a role in shaping TCBQ-induced apoptosis in mouse embryonic stem cells. Our study provides new insights into the toxicology of PCP and its reactive metabolite TCBQ.
[Mh] Termos MeSH primário: Cloranila/toxicidade
Fungicidas Industriais/toxicidade
[Mh] Termos MeSH secundário: 5-Metilcitosina/análogos & derivados
Animais
Apoptose
Citosina/análogos & derivados
Citosina/metabolismo
Camundongos
Células-Tronco Embrionárias Murinas
Testes de Toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungicides, Industrial); 01W5X7N5XV (Chloranil); 1123-95-1 (5-hydroxymethylcytosine); 6R795CQT4H (5-Methylcytosine); 8J337D1HZY (Cytosine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE


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[PMID]:28115119
[Au] Autor:Zuehlke A; Zhang H
[Ad] Endereço:Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, T6G 2G3, Canada.
[Ti] Título:Elevated 5-hydroxymethycytosine and cell apoptosis induced by tetrachloro-1,4-benzoquinone in mouse embryonic stem cells.
[So] Source:J Environ Sci (China);51:1-4, 2017 Jan.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Cloranila/toxicidade
Citosina/análogos & derivados
Fungicidas Industriais/toxicidade
[Mh] Termos MeSH secundário: 5-Metilcitosina/análogos & derivados
Animais
Apoptose/fisiologia
Citosina/metabolismo
Camundongos
Células-Tronco Embrionárias Murinas
Testes de Toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fungicides, Industrial); 01W5X7N5XV (Chloranil); 1123-95-1 (5-hydroxymethylcytosine); 6R795CQT4H (5-Methylcytosine); 8J337D1HZY (Cytosine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE


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[PMID]:28041953
[Au] Autor:Larik FA; Saeed A; Shahzad D; Faisal M; El-Seedi H; Mehfooz H; Channar PA
[Ad] Endereço:Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan.
[Ti] Título:Synthetic approaches towards the multi target drug spironolactone and its potent analogues/derivatives.
[So] Source:Steroids;118:76-92, 2017 Feb.
[Is] ISSN:1878-5867
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Spironolactone is a well-known multi-target drug and is specifically used for the treatment of high blood pressure and heart failure. It is also used for the treatment of edema, cirrhosis of the liver, malignant, pediatric, nephrosis and primary hyperaldosteronism. Spironolactone in association with thiazide diuretics treats hypertension and in association with furosemide treats bronchopulmonary dyspepsia. The therapeutic mechanism of action of spironolactone involves binding to intracellular mineralocorticoids receptors (MRs) in kidney epithelial cells, thereby inhibiting the binding of aldosterone. Since its first synthesis in 1957 there are several synthetic approaches have been reported throughout the years, Synthetic community has devoted efforts to improve the synthesis of spironolactone and to synthesize its analogues and derivatives. This review aims to provide comprehensive insight for the synthetic endeavors devoted towards the synthesis of a versatile drug spironolactone and its analogues/derivatives.
[Mh] Termos MeSH primário: Aldosterona/síntese química
Canrenona/síntese química
Espironolactona/análogos & derivados
Espironolactona/química
Espironolactona/síntese química
[Mh] Termos MeSH secundário: Aldosterona/química
Androstadienos/química
Androstenos/química
Animais
Canrenona/química
Cloranila/química
Desidroepiandrosterona/química
Seres Humanos
Estrutura Molecular
Receptores de Mineralocorticoides/metabolismo
Espironolactona/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Androstadienes); 0 (Androstenes); 0 (Receptors, Mineralocorticoid); 01W5X7N5XV (Chloranil); 27O7W4T232 (Spironolactone); 459AG36T1B (Dehydroepiandrosterone); 4964P6T9RB (Aldosterone); 6995V82D0B (eplerenone); 78O20X9J0U (Canrenone); B8TEV07170 (spirorenone); N295J34A25 (drospirenone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170103
[St] Status:MEDLINE


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[PMID]:27749247
[Au] Autor:Refat MS; Saad HA; Adam AM; Al-Omar MA; Naglah AM
[Ti] Título:Charge transfer interaction of organic p-acceptors with the anti-hyperuricemic drug allopurinol: Insights from IR, Raman, 1H NMR and 13C NMR spectroscopies.
[So] Source:Acta Pharm;66(4):533-542, 2016 Dec 01.
[Is] ISSN:1846-9558
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:The topic of charge-transfer (CT) complexation of vital drugs has attracted considerable attention in recent years owing to their significant physical and chemical properties. In this study, CT complexes derived from the reaction of the anti-hyperuricemic drug allopurinol (Allop) with organic p-acceptors [(picric acid (PA), dichlorodicyanobenzoquinone (DDQ) and chloranil (CHL)] were prepared, isolated and characterized by a range of physicochemical methods, such as IR, Raman, 1H NMR and 13C NMR spectroscopy. The stoichiometry of the complexes was verified by elemental analysis. The results show that all complexes that were formed were based on a 1:1 stoichiometric ratio. This study suggests that the complexation of Allop with either the DDQ or CHL acceptor leads to a direct p®p* transition, whereas the molecules of Allop and PA are linked by intermolecular hydrogen- bonding interactions.
[Mh] Termos MeSH primário: Alopurinol/química
Benzoquinonas/química
Cloranila/química
Inibidores Enzimáticos/química
Supressores da Gota/química
Oxidantes/química
Xantina Oxidase/antagonistas & inibidores
[Mh] Termos MeSH secundário: Espectroscopia de Ressonância Magnética Nuclear de Carbono-13
Fenômenos Químicos
Elétrons
Ligações de Hidrogênio
Cinética
Oxirredução
Picratos/química
Espectroscopia de Prótons por Ressonância Magnética
Espectrofotometria Infravermelho
Análise Espectral Raman
Desacopladores/química
Xantina Oxidase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoquinones); 0 (Enzyme Inhibitors); 0 (Gout Suppressants); 0 (Oxidants); 0 (Picrates); 0 (Uncoupling Agents); 01W5X7N5XV (Chloranil); 1H5KD39UH7 (dichlorodicyanobenzoquinone); 63CZ7GJN5I (Allopurinol); A49OS0F91S (picric acid); EC 1.17.3.2 (Xanthine Oxidase)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161018
[St] Status:MEDLINE


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[PMID]:25677533
[Au] Autor:Refat MS; Saad HA; Adam AM
[Ad] Endereço:Department of Chemistry, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, Zip Code 21974 Taif, Saudi Arabia; Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt. Electronic address: msrefat@yahoo.com.
[Ti] Título:Spectral, thermal and kinetic studies of charge-transfer complexes formed between the highly effective antibiotic drug metronidazole and two types of acceptors: σ- and π-acceptors.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;141:202-10, 2015 Apr 15.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Understanding the interaction between drugs and small inorganic or organic molecules is critical in being able to interpret the drug-receptor interactions and acting mechanism of these drugs. A combined solution and solid state study was performed to describe the complexation chemistry of drug metronidazole (MZ) which has a broad-spectrum antibacterial activity with two types of acceptors. The acceptors include, σ-acceptor (i.e., iodine) and π-acceptors (i.e., dichlorodicyanobenzoquinone (DDQ), chloranil (CHL) and picric acid (PA)). The molecular structure, spectroscopic characteristics, the binding modes as well as the thermal stability were deduced from IR, UV-vis, (1)H NMR and thermal studies. The binding ratio of complexation (MZ: acceptor) was determined to be 1:2 for the iodine acceptor and 1:1 for the DDQ, CHL or PA acceptor, according to the CHN elemental analyses and spectrophotometric titrations. It has been found that the complexation with CHL and PA acceptors increases the values of enthalpy and entropy, while the complexation with DDQ and iodine acceptors decreases the values of these parameters compared with the free MZ donor.
[Mh] Termos MeSH primário: Antibacterianos/química
Elétrons
Metronidazol/química
Análise Espectral Raman
Temperatura Ambiente
[Mh] Termos MeSH secundário: Benzoquinonas/química
Cloranila/química
Entropia
Iodo/química
Cinética
Picratos/química
Espectroscopia de Prótons por Ressonância Magnética
Espectrofotometria Infravermelho
Termogravimetria
Vibração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Benzoquinones); 0 (Picrates); 01W5X7N5XV (Chloranil); 140QMO216E (Metronidazole); 1H5KD39UH7 (dichlorodicyanobenzoquinone); 9679TC07X4 (Iodine); A49OS0F91S (picric acid)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150214
[St] Status:MEDLINE


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[PMID]:25613694
[Au] Autor:Abdel-Aziz O; Ayad MF; Tadros MM
[Ad] Endereço:Analytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, Egypt.
[Ti] Título:Compatible validated spectrofluorimetric and spectrophotometric methods for determination of vildagliptin and saxagliptin by factorial design experiments.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;140:229-40, 2015 Apr 05.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Simple, selective and reproducible spectrofluorimetric and spectrophotometric methods have been developed for the determination of vildagliptin and saxagliptin in bulk and their pharmaceutical dosage forms. The first proposed spectrofluorimetric method is based on the dansylation reaction of the amino group of vildagliptin with dansyl chloride to form a highly fluorescent product. The formed product was measured spectrofluorimetrically at 455 nm after excitation at 345 nm. Beer's law was obeyed in a concentration range of 100-600 µg ml(-1). The second proposed spectrophotometric method is based on the charge transfer complex of saxagliptin with tetrachloro-1,4-benzoquinone (p-chloranil). The formed charge transfer complex was measured spectrophotometrically at 530 nm. Beer's law was obeyed in a concentration range of 100-850 µg ml(-1). The third proposed spectrophotometric method is based on the condensation reaction of the primary amino group of saxagliptin with formaldehyde and acetyl acetone to form a yellow colored product known as Hantzsch reaction, measured at 342.5 nm. Beer's law was obeyed in a concentration range of 50-300 µg ml(-1). All the variables were studied to optimize the reactions' conditions using factorial design. The developed methods were validated and proved to be specific and accurate for quality control of vildagliptin and saxagliptin in their pharmaceutical dosage forms.
[Mh] Termos MeSH primário: Adamantano/análogos & derivados
Dipeptídeos/análise
Inibidores da Dipeptidil Peptidase IV/análise
Nitrilos/análise
Pirrolidinas/análise
[Mh] Termos MeSH secundário: Adamantano/análise
Benzoquinonas/química
Cloranila/química
Limite de Detecção
Espectrometria de Fluorescência/métodos
Espectrofotometria/métodos
Comprimidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Benzoquinones); 0 (Dipeptides); 0 (Dipeptidyl-Peptidase IV Inhibitors); 0 (Nitriles); 0 (Pyrrolidines); 0 (Tablets); 01W5X7N5XV (Chloranil); 3T006GV98U (quinone); 9GB927LAJW (saxagliptin); I6B4B2U96P (vildagliptin); PJY633525U (Adamantane)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150124
[St] Status:MEDLINE


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[PMID]:25305619
[Au] Autor:Karmakar A; Chaudhuri T; Mula S; Chattopadhyay S
[Ad] Endereço:Department of Chemistry, Dr. Bhupendranath Dutta Smriti Mahavidyalaya, Burdwan 713 407, India.
[Ti] Título:Charge transfer in the electron donor-acceptor complexes of a meso-phenol BODIPY dye with chloranils and fullerenes.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;137:1258-64, 2015 Feb 25.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:UV-Vis spectral investigations of electron donor-acceptor complexes of laser dye 2,6-Diethyl-4,4-difluoro-1,3,5,7-tetramethyl-8-(4'-hydroxyphenyl)-4-bora-3a,4a-diaza-s-indecene (1c) with chloranils and fullerenes are reported in toluene medium. Well defined charge transfer (CT) absorption bands have been located in the visible region. Oscillator strengths, transition dipole and resonance energies of the CT complexes have been estimated. Vertical ionization potential of 1c has been determined utilizing Mulliken's equation. A possible mechanism for the interaction between electronic subsystems of chloranils, [60]- and [70]fullerenes with three different BODIPY dyes (1a, 1b and 1c shown in Fig. 1) have been discussed in comparing the parameters like degree of charge transfer and binding constant in nonpolar toluene. Comparison of 1c complexes is done with DFT/B3LYP/6-31G optimized gas phase geometries.
[Mh] Termos MeSH primário: Compostos de Boro/química
Cloranila/química
Corantes/química
Fulerenos/química
Fenol/química
[Mh] Termos MeSH secundário: Transporte de Elétrons
Modelos Moleculares
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene); 0 (Boron Compounds); 0 (Coloring Agents); 0 (Fullerenes); 01W5X7N5XV (Chloranil); 339NCG44TV (Phenol)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:141208
[Lr] Data última revisão:
141208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141012
[St] Status:MEDLINE


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[PMID]:25238182
[Au] Autor:El-Sheshtawy HS; Salman HM; El-Kemary M
[Ad] Endereço:Biotechnology and Fish Processing Department, Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University, 33516 Kafr ElSheikh, Egypt; Nanochemistry Laboratory, Chemistry Department, Faculty of Science, Kafrelsheikh University, 33516 Kafr ElSheikh, Egypt. Electronic address: h.elsheshtawy@fsh.kfs.edu.eg.
[Ti] Título:Halogen vs hydrogen bonding in thiazoline-2-thione stabilization with σ- and π-electron acceptors adducts: theoretical and experimental study.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;137:442-9, 2015 Feb 25.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Molecular charge-transfer complexes (CT) between thiazoline-2-thione (THZ) and different σ- (I2) and π-acceptors (Tetracyanoethylene (TCNE), 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), and 2,3,5,6-tetrachloro-1,4-benzoquinone (CHL)) were investigated. UV-Vis absorption spectroscopy and theoretical calculations using both MP2/aug-cc-pVDZ-PP and B3LYP/6-311++G(d,p) level of theory were corroborated to study the nature of the stabilizing forces for THZ-I2, THZ-DDQ, THZ-TCNE, and THZ-CHL. Halogen bonding (XB) was the stabilizing attractive force in THZ-I2 and THZ-CHL whereas; hydrogen bonding (HB) was dominated in both THZ-TCNE, and THZ-DDQ complexes. Formation constant (K), extinction coefficient (É›), thermodynamic parameters such as enthalpy change (ΔH), entropy (ΔS), and Gibbs free energy (ΔG) were measured in different solvents.
[Mh] Termos MeSH primário: Halogênios/química
Modelos Químicos
Tiazolidinas/química
[Mh] Termos MeSH secundário: Benzoquinonas/química
Cloranila/química
Elétrons
Etilenos/química
Ligações de Hidrogênio
Modelos Moleculares
Estrutura Molecular
Nitrilos/química
Solventes/química
Espectrofotometria Ultravioleta
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoquinones); 0 (Ethylenes); 0 (Halogens); 0 (Nitriles); 0 (Solvents); 0 (Thiazolidines); 01W5X7N5XV (Chloranil); 1H5KD39UH7 (dichlorodicyanobenzoquinone); 5685-05-2 (thiazoline-2-thione); C592309ECU (tetracyanoethylene)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140920
[St] Status:MEDLINE


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[PMID]:24816176
[Au] Autor:Xu D; Hu L; Xia X; Song J; Li L; Song E; Song Y
[Ad] Endereço:Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, PR China.
[Ti] Título:Tetrachlorobenzoquinone induces acute liver injury, up-regulates HO-1 and NQO1 expression in mice model: the protective role of chlorogenic acid.
[So] Source:Environ Toxicol Pharmacol;37(3):1212-20, 2014 May.
[Is] ISSN:1872-7077
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Tetrachlorobenzoquinone (TCBQ) is an active metabolite of pentachlorophenol (PCP). Although PCP has been investigated extensively, there are only a few reports describing the toxicity effect of TCBQ, and no report regarding TCBQ-induced liver injury in vivo. In the current study, we aimed to examine the acute hepatic toxicity of TCBQ in the mice model. Chlorogenic acid (CGA) exhibits promising antioxidant activity in the past studies, thus, the second aim of this study was to evaluate the protective effect of CGA on TCBQ-induced liver injury. Our results indicated TCBQ-intoxication caused marked liver cell necrosis and inflammation but not apoptosis, and this damage was alleviated by CGA treatment. Meantime, TCBQ-intoxication enhanced serum ALT, AST activities, TBIL content, hepatic oxidative stress and lipid peroxidation, decreased GSH content and inhibited the activities of antioxidant enzymes. Western blot and immunohistochemical analysis showed that TCBQ marked up-regulated HO-1 and NQO1 expression. On the other hand, pretreatment of CGA reduced TCBQ-induced liver damage remarkably. Taking together, these results revealed that TCBQ has strong hepatic toxic effect, and at least a part of this effect is initiated by free radical and relieved with CGA administration.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Cloranila/toxicidade
Ácido Clorogênico/uso terapêutico
Fungicidas Industriais/toxicidade
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Animais
Antioxidantes/farmacologia
Aspartato Aminotransferases/sangue
Catalase/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/patologia
Ácido Clorogênico/farmacologia
Glutationa/metabolismo
Glutationa Peroxidase/metabolismo
Glutationa Redutase/metabolismo
Heme Oxigenase-1/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Fígado/efeitos dos fármacos
Fígado/metabolismo
Fígado/patologia
Masculino
Proteínas de Membrana/metabolismo
Camundongos
NAD(P)H Desidrogenase (Quinona)/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Superóxido Dismutase/metabolismo
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Fungicides, Industrial); 0 (Membrane Proteins); 0 (Reactive Oxygen Species); 01W5X7N5XV (Chloranil); 318ADP12RI (Chlorogenic Acid); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.14.14.18 (Heme Oxygenase-1); EC 1.14.14.18 (Hmox1 protein, mouse); EC 1.15.1.1 (Superoxide Dismutase); EC 1.6.5.2 (NAD(P)H Dehydrogenase (Quinone)); EC 1.6.5.2 (Nqo1 protein, mouse); EC 1.8.1.7 (Glutathione Reductase); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140513
[St] Status:MEDLINE



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