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[PMID]:28855417
[Au] Autor:Elango R; Humayun MA; Turner JM; Rafii M; Langos V; Ball RO; Pencharz PB
[Ad] Endereço:BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada; relango@bcchr.ubc.ca.
[Ti] Título:Total Sulfur Amino Acid Requirements Are Not Altered in Children with Chronic Renal Insufficiency, but Minimum Methionine Needs Are Increased.
[So] Source:J Nutr;147(10):1954-1959, 2017 Oct.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The total sulfur amino acid (TSAA) and minimum Met requirements have been previously determined in healthy children. TSAA metabolism is altered in kidney disease. Whether TSAA requirements are altered in children with chronic renal insufficiency (CRI) is unknown. We sought to determine the TSAA (Met in the absence of Cys) requirements and minimum Met (in the presence of excess Cys) requirements in children with CRI. Five children (4 boys, 1 girl) aged 10 ± 2.6 y with CRI were randomly assigned to receive graded intakes of Met (0, 5, 10, 15, 25, and 35 mg · kg · d ) with no Cys in the diet. Four of the children (3 boys, 1 girl) were then randomly assigned to receive graded dietary intakes of Met (0, 2.5, 5, 7.5, 10, and 15 mg · kg · d ) with 21 mg · kg · d Cys. The mean TSAA and minimum Met requirements were determined by measuring the oxidation of l-[1- C]Phe to CO (F CO ). A 2-phase linear-regression crossover analysis of the F CO data identified a breakpoint at minimal F CO Urine samples collected from all study days and from previous studies of healthy children were measured for sulfur metabolites. The mean and population-safe (upper 95% CI) intakes of TSAA and minimum Met in children with CRI were determined to be 12.6 and 15.9 mg · kg · d and 7.3 and 10.9 mg · kg · d , respectively. In healthy school-aged children the mean and upper 95% CI intakes of TSAA and minimum Met were determined to be 12.9 and 17.2 mg · kg · d and 5.8 and 7.3 mg · kg · d , respectively. A comparison of the minimum Met requirements between healthy children and children with CRI indicated significant ( < 0.05) differences. These results suggest that children with CRI have a similar mean and population-safe TSAA to that of healthy children, suggesting adequate Cys synthesis via transsulfuration, but higher minimum Met requirement, suggesting reduced remethylation rates.
[Mh] Termos MeSH primário: Dieta
Metionina/administração & dosagem
Necessidades Nutricionais
Insuficiência Renal Crônica
[Mh] Termos MeSH secundário: Aminoácidos Sulfúricos/administração & dosagem
Aminoácidos Sulfúricos/metabolismo
Carbono/metabolismo
Isótopos de Carbono/metabolismo
Criança
Estudos Cross-Over
Cisteína/metabolismo
Feminino
Seres Humanos
Masculino
Metionina/metabolismo
Metilação
Oxirredução
Fenilalanina/metabolismo
Valores de Referência
Insuficiência Renal Crônica/complicações
Insuficiência Renal Crônica/metabolismo
Enxofre/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Amino Acids, Sulfur); 0 (Carbon Isotopes); 47E5O17Y3R (Phenylalanine); 70FD1KFU70 (Sulfur); 7440-44-0 (Carbon); AE28F7PNPL (Methionine); K848JZ4886 (Cysteine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.3945/jn.116.244301


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[PMID]:27965088
[Au] Autor:Kotaka K; Nagai J; Hensley K; Ohshima T
[Ad] Endereço:Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, TWIns, Tokyo, 162-8480, Japan.
[Ti] Título:Lanthionine ketimine ester promotes locomotor recovery after spinal cord injury by reducing neuroinflammation and promoting axon growth.
[So] Source:Biochem Biophys Res Commun;483(1):759-764, 2017 Jan 29.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The mammalian central nervous system (CNS) has limited regenerative ability after injury, largely due to scar formation and axonal growth inhibitors. Experimental suppression of neuroinflammation encourages recovery from spinal cord injury (SCI), yet practical means for pharmacologically treating SCI have remained elusive. Lanthionine ketimine (LK) is a natural brain sulfur amino acid metabolite with demonstrated anti-neuroinflammatory and neurotrophic activities. LK and its synthetic brain-penetrating ethyl ester (LKE) promote growth factor-dependent neurite extension in cultured cell and suppress microglial activation in animal models of neurodegeneration. Thus far however, LKE has not been explored as a potential therapy for SCI. The present study investigated the hypothesis that systemic LKE could improve motor functional recovery after SCI in a mouse model. Intraperitoneal administration of LKE (100 mg/kg/d) after near-complete transect of spinal cord at the T7 level significantly improved motor function over a 4-week time course. Vehicle-treated mice, in contrast, demonstrated negligible functional recovery. In terms of histology, LKE treatment reduced pro-neuroinflammatory microglia/macrophage activation evidenced by quantitative Iba1 labeling and shifted the microglial phenotype toward a more neurotrophic M2 character evidenced by changes in the M2 marker arginase-1. This was correlated with less dense scar formation and more extensive axonal regrowth across the transection site demonstrated by 5-hydroxytryptamine (5HT) immunolabeling of raphespinal tract axons. These data provide evidence that LKE or similar compounds have potential therapeutic value for recovery after certain forms of SCI.
[Mh] Termos MeSH primário: Aminoácidos Sulfúricos/uso terapêutico
Anti-Inflamatórios não Esteroides/uso terapêutico
Recuperação de Função Fisiológica/efeitos dos fármacos
Traumatismos da Medula Espinal/tratamento farmacológico
Medula Espinal/fisiopatologia
[Mh] Termos MeSH secundário: Aminoácidos Sulfúricos/farmacologia
Animais
Anti-Inflamatórios não Esteroides/farmacologia
Axônios/efeitos dos fármacos
Axônios/fisiologia
Biomarcadores/análise
Células Cultivadas
Modelos Animais de Doenças
Feminino
Inflamação/tratamento farmacológico
Inflamação/patologia
Locomoção/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos C57BL
Microglia/efeitos dos fármacos
Microglia/patologia
Microglia/fisiologia
Neuritos/efeitos dos fármacos
Neuritos/fisiologia
Serotonina/metabolismo
Medula Espinal/efeitos dos fármacos
Traumatismos da Medula Espinal/patologia
Traumatismos da Medula Espinal/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids, Sulfur); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Biomarkers); 333DO1RDJY (Serotonin); 83711-67-5 (lanthionine ketimine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170529
[Lr] Data última revisão:
170529
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161215
[St] Status:MEDLINE


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[PMID]:27120188
[Au] Autor:Hooshmand B; Mangialasche F; Kalpouzos G; Solomon A; Kåreholt I; Smith AD; Refsum H; Wang R; Mühlmann M; Ertl-Wagner B; Laukka EJ; Bäckman L; Fratiglioni L; Kivipelto M
[Ad] Endereço:Center for Alzheimer Research-Aging Research Center, Karolinska Institutet, Stockholm University, Stockholm, Sweden2Department of Neurology, Klinikum Augsburg, Augsburg, Germany.
[Ti] Título:Association of Vitamin B12, Folate, and Sulfur Amino Acids With Brain Magnetic Resonance Imaging Measures in Older Adults: A Longitudinal Population-Based Study.
[So] Source:JAMA Psychiatry;73(6):606-13, 2016 Jun 01.
[Is] ISSN:2168-6238
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:IMPORTANCE: Vitamin B12, folate, and sulfur amino acids may be modifiable risk factors for structural brain changes that precede clinical dementia. OBJECTIVE: To investigate the association of circulating levels of vitamin B12, red blood cell folate, and sulfur amino acids with the rate of total brain volume loss and the change in white matter hyperintensity volume as measured by fluid-attenuated inversion recovery in older adults. DESIGN, SETTING, AND PARTICIPANTS: The magnetic resonance imaging subsample of the Swedish National Study on Aging and Care in Kungsholmen, a population-based longitudinal study in Stockholm, Sweden, was conducted in 501 participants aged 60 years or older who were free of dementia at baseline. A total of 299 participants underwent repeated structural brain magnetic resonance imaging scans from September 17, 2001, to December 17, 2009. MAIN OUTCOMES AND MEASURES: The rate of brain tissue volume loss and the progression of total white matter hyperintensity volume. RESULTS: In the multi-adjusted linear mixed models, among 501 participants (300 women [59.9%]; mean [SD] age, 70.9 [9.1] years), higher baseline vitamin B12 and holotranscobalamin levels were associated with a decreased rate of total brain volume loss during the study period: for each increase of 1 SD, ß (SE) was 0.048 (0.013) for vitamin B12 (P < .001) and 0.040 (0.013) for holotranscobalamin (P = .002). Increased total homocysteine levels were associated with faster rates of total brain volume loss in the whole sample (ß [SE] per 1-SD increase, -0.035 [0.015]; P = .02) and with the progression of white matter hyperintensity among participants with systolic blood pressure greater than 140 mm Hg (ß [SE] per 1-SD increase, 0.000019 [0.00001]; P = .047). No longitudinal associations were found for red blood cell folate and other sulfur amino acids. CONCLUSIONS AND RELEVANCE: This study suggests that both vitamin B12 and total homocysteine concentrations may be related to accelerated aging of the brain. Randomized clinical trials are needed to determine the importance of vitamin B12 supplementation on slowing brain aging in older adults.
[Mh] Termos MeSH primário: Doença de Alzheimer/diagnóstico por imagem
Doença de Alzheimer/fisiopatologia
Aminoácidos Sulfúricos/sangue
Encéfalo/diagnóstico por imagem
Ácido Fólico/sangue
Imagem por Ressonância Magnética
Vitamina B 12/sangue
[Mh] Termos MeSH secundário: Idoso
Atrofia
Encéfalo/patologia
Feminino
Homocisteína/sangue
Seres Humanos
Modelos Lineares
Estudos Longitudinais
Masculino
Meia-Idade
Fatores de Risco
Estatística como Assunto
Suécia
Substância Branca/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids, Sulfur); 0LVT1QZ0BA (Homocysteine); 935E97BOY8 (Folic Acid); P6YC3EG204 (Vitamin B 12)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160428
[St] Status:MEDLINE
[do] DOI:10.1001/jamapsychiatry.2016.0274


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[PMID]:26994191
[Au] Autor:Ekmay RD; Mei SJ; Sakomura NK; Coon CN
[Ad] Endereço:University of Arkansas, Center of Excellence for Poultry Science, Fayetteville, Arkansas 72701.
[Ti] Título:The cysteine, total sulfur amino acid, tyrosine, phenylalanine + tyrosine, and non-essential amino acid maintenance requirements of broiler breeders.
[So] Source:Poult Sci;95(6):1341-7, 2016 Jun 01.
[Is] ISSN:1525-3171
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two hundred and fifty Cobb-Vantress broiler breeders were used to determine the maintenance requirement and efficiency of utilization of dietary Cys, Tyr, and non-essential amino acids (AA) in a 21-day experiment. The breeders were fed crystalline amino acid diets containing graded levels of Cys or Tyr representing 0, 10, 20, 30, and 40% of their suggested requirement level with all other amino acids maintained at 40% of their suggested requirement level. To determine the non-essential AA maintenance requirement, graded levels of non-essential AA were provided by glutamic acid to represent 12, 19, 26, 33, and 40% of the ideal level of glutamic acid with all other amino acids maintained at their maintenance requirement level. The total sulfur amino acid (TSAA) and Phe + Tyr requirements were calculated by combining Cys and Tyr results, respectively, with previously determined Met and Phe, respectively. The slope of Cys, Tyr, and non-essential AA accretion regression line indicated that 29% Cys, 24% TSAA, 21% Tyr, 20% Phe + Tyr, and 9% non-essential AA of crystalline amino acids were retained. The Cys requirement for zero protein accretion was calculated to be 30.48 mg/d or 17.006 mg/ kgBW(0.75)/d or 75.426 mg/kgCP/d. The TSAA requirement for zero accretion was calculated to be 132.25 mg/b/d, 71.48 mg/kgBW(0.75)/d, and 307.55 mg/kgCP/d. The Tyr requirement for zero protein accretion was calculated to be 65.907 mg/d or 37.233 mg/ kgBW(0.75)/d or 175.566 mg/kgCP/d. The Phe + Tyr requirement for zero protein accretion was calculated to be 352.18 mg/b/d, 190.37 mg/kgBW(0.75)/d, and 749.33 mg/kgCP/d. The non-essential AA requirement for zero protein accretion was calculated to be 3715.194 mg/d or 2003.155 mg/kgBW(0.75)/d or 9452.954 mg/kgCP/d.
[Mh] Termos MeSH primário: Aminoácidos/metabolismo
Galinhas/metabolismo
Necessidades Nutricionais
[Mh] Termos MeSH secundário: Aminoácidos Sulfúricos/metabolismo
Ração Animal/análise
Fenômenos Fisiológicos da Nutrição Animal/efeitos dos fármacos
Animais
Cisteína/metabolismo
Dieta/veterinária
Feminino
Fenilalanina/metabolismo
Distribuição Aleatória
Tirosina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Amino Acids, Sulfur); 42HK56048U (Tyrosine); 47E5O17Y3R (Phenylalanine); K848JZ4886 (Cysteine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160320
[St] Status:MEDLINE
[do] DOI:10.3382/ps/pew031


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[PMID]:26831912
[Au] Autor:Jakubowski H
[Ad] Endereço:Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, International Center for Public Health, Newark, NJ, USA.
[Ti] Título:Aminoacyl-tRNA synthetases and the evolution of coded peptide synthesis: the Thioester World.
[So] Source:FEBS Lett;590(4):469-81, 2016 Feb.
[Is] ISSN:1873-3468
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Coded peptide synthesis must have been preceded by a prebiotic stage, in which thioesters played key roles. Fossils of the Thioester World are found in extant aminoacyl-tRNA synthetases (AARSs). Indeed, studies of the editing function reveal that AARSs have a thiol-binding site in their catalytic modules. The thiol-binding site confers the ability to catalyze aminoacyl~coenzyme A thioester synthesis and peptide bond formation. Genomic comparisons show that AARSs are structurally related to proteins involved in sulfur and coenzyme A metabolisms and peptide bond synthesis. These findings point to the origin of the amino acid activation and peptide bond synthesis functions in the Thioester World and suggest that the present-day AARSs had originated from ancestral forms that were involved in noncoded thioester-dependent peptide synthesis.
[Mh] Termos MeSH primário: Aminoácidos Sulfúricos/síntese química
Aminoacil-tRNA Sintetases/química
Evolução Molecular
Biossíntese Peptídica
Peptídeos/química
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Aminoacilação
Biocatálise
Domínio Catalítico
Código Genético
Dados de Sequência Molecular
Origem da Vida
Biossíntese Peptídica/genética
Peptídeos/genética
Compostos de Sulfidrila/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amino Acids, Sulfur); 0 (Peptides); 0 (Sulfhydryl Compounds); EC 6.1.1.- (Amino Acyl-tRNA Synthetases)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160222
[Lr] Data última revisão:
160222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160203
[St] Status:MEDLINE
[do] DOI:10.1002/1873-3468.12085


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[PMID]:26647293
[Au] Autor:Selhub J; Troen AM
[Ad] Endereço:Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts.
[Ti] Título:Sulfur amino acids and atherosclerosis: a role for excess dietary methionine.
[So] Source:Ann N Y Acad Sci;1363:18-25, 2016 Jan.
[Is] ISSN:1749-6632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The homocysteine theory of arteriosclerosis received credence when it was shown that after a methionine load, circulating homocysteine-cysteine concentrations were higher in cardiovascular disease patients than in healthy controls. Subsequent studies showing associations between homocysteine and coronary artery disease, stroke and cognitive impairment, relied on small increases in homocysteine concentration unlike the very high homocysteine seen in the rare genetic disorders that lead to homocystinuria and much higher homocysteine levels. Subsequent studies in cell culture, animals, and humans showed that a variety of cardiovascular adverse effects of "high homocysteine" introduced either as a nonphysiological bolus or as a methionine load led to high homocysteine. We fed apolipoprotein E-deficient mice diets designed to achieve three conditions: (1) high methionine intake with normal blood homocysteine, (2) high methionine intake with B vitamin deficiency and hyperhomocysteinemia, and (3) normal methionine intake with both B vitamin deficiency and hyperhomocysteinemia. We found that the mice fed methionine-rich diets had significant atheromatous pathology in the aortic arch even with normal plasma homocysteine levels. Mice fed B vitamin-deficient diets developed severe hyperhomocysteinemia but without any increase in vascular pathology. Our findings suggest that even moderate increases in methionine intake are atherogenic in susceptible mice while high plasma homocysteine is not.
[Mh] Termos MeSH primário: Aminoácidos Sulfúricos/metabolismo
Aterosclerose/etiologia
Aterosclerose/metabolismo
[Mh] Termos MeSH secundário: Aminoácidos Sulfúricos/sangue
Animais
Apolipoproteínas E/deficiência
Aterosclerose/sangue
Aterosclerose/patologia
Biomarcadores
Análise Química do Sangue
Dieta
Modelos Animais de Doenças
Homocisteína/sangue
Homocisteína/metabolismo
Redes e Vias Metabólicas
Metionina/sangue
Metionina/metabolismo
Camundongos
Camundongos Knockout
Placa Aterosclerótica/patologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amino Acids, Sulfur); 0 (Apolipoproteins E); 0 (Biomarkers); 0LVT1QZ0BA (Homocysteine); AE28F7PNPL (Methionine)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160321
[Lr] Data última revisão:
160321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151210
[St] Status:MEDLINE
[do] DOI:10.1111/nyas.12962


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[PMID]:26646941
[Au] Autor:Mullin JM; Skrovanek SM; Ramalingam A; DiGuilio KM; Valenzano MC
[Ad] Endereço:Lankenau Institute for Medical Research, Wynnewood, Pennsylvania.
[Ti] Título:Methionine restriction fundamentally supports health by tightening epithelial barriers.
[So] Source:Ann N Y Acad Sci;1363:59-67, 2016 Jan.
[Is] ISSN:1749-6632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dietary methionine restriction (MR) has been found to affect one of the most primary tissue-level functions of an organism: the efficiency with which the epithelial linings of major organs separate the fluid compartments that they border. This process, epithelial barrier function, is basic for proper function of all organs, including the lung, liver, gastrointestinal tract, reproductive tract, blood-brain barrier, and kidney. Specifically, MR has been found to modify the protein composition of tight junctional complexes surrounding individual epithelial cells in a manner that renders the complexes less leaky. This has been observed in both a renal epithelial cell culture model and in gastrointestinal tissue. In both cases, MR increased the transepithelial electrical resistance across the epithelium, while decreasing passive leak of small nonelectrolytes. However, the specific target protein modifications involved were unique to each case. Overall, this provides an example of the primary level on which MR functions to modify, and improve, an organism.
[Mh] Termos MeSH primário: Restrição Calórica
Epitélio/fisiologia
Saúde
Metionina/metabolismo
[Mh] Termos MeSH secundário: Aminoácidos Sulfúricos/metabolismo
Animais
Transporte Biológico
Suscetibilidade a Doenças
Seres Humanos
Micronutrientes/metabolismo
Ocludina/metabolismo
Permeabilidade
Junções Íntimas/metabolismo
Junções Íntimas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Amino Acids, Sulfur); 0 (Micronutrients); 0 (Occludin); AE28F7PNPL (Methionine)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151210
[St] Status:MEDLINE
[do] DOI:10.1111/nyas.12955


  8 / 1210 MEDLINE  
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[PMID]:26599618
[Au] Autor:Kruger WD; Gupta S
[Ad] Endereço:Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
[Ti] Título:The effect of dietary modulation of sulfur amino acids on cystathionine ß synthase-deficient mice.
[So] Source:Ann N Y Acad Sci;1363:80-90, 2016 Jan.
[Is] ISSN:1749-6632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cystathionine ß synthase (CBS) is a key enzyme in the methionine and cysteine metabolic pathway, acting as a metabolic gatekeeper to regulate the flow of fixed sulfur from methionine to cysteine. Mutations in the CBS gene cause clinical CBS deficiency, a disease characterized by elevated plasma total homocysteine (tHcy) and methionine and decreased plasma cysteine. The treatment goal for CBS-deficient patients is to normalize the metabolic values of these three metabolites using a combination of vitamin therapy and dietary manipulation. To better understand the effectiveness of nutritional treatment strategies, we have performed a series of long-term dietary manipulation studies using our previously developed Tg-I278T Cbs(-/-) mouse model of CBS deficiency and sibling Tg-I278T Cbs(+/-) controls. Tg-I278T Cbs(-/-) mice have undetectable levels of CBS activity, extremely elevated plasma tHcy, modestly elevated plasma methionine, and low plasma cysteine. They exhibit several easily assayable phenotypes, including osteoporosis, loss of fat mass, reduced life span, and facial alopecia. The diets used in these studies differed in the amounts of sulfur amino acids or sulfur amino acid precursors. In this review, we will discuss our findings and their relevance to CBS deficiency and the concept of gene-diet interaction.
[Mh] Termos MeSH primário: Aminoácidos Sulfúricos/metabolismo
Cistationina beta-Sintase/deficiência
Dieta
Homocistinúria/genética
Homocistinúria/metabolismo
[Mh] Termos MeSH secundário: Acetilcisteína/administração & dosagem
Animais
Betaína/administração & dosagem
Cistationina beta-Sintase/genética
Suplementos Nutricionais
Modelos Animais de Doenças
Genótipo
Homocistinúria/dietoterapia
Seres Humanos
Redes e Vias Metabólicas
Metionina/administração & dosagem
Metionina/metabolismo
Camundongos
Camundongos Knockout
Mutação
Fenótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Amino Acids, Sulfur); 3SCV180C9W (Betaine); AE28F7PNPL (Methionine); EC 4.2.1.22 (Cystathionine beta-Synthase); WYQ7N0BPYC (Acetylcysteine)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151125
[St] Status:MEDLINE
[do] DOI:10.1111/nyas.12967


  9 / 1210 MEDLINE  
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[PMID]:26335055
[Au] Autor:Conde-Aguilera JA; Le Floc'h N; Le Huërou-Luron I; Mercier Y; Tesseraud S; Lefaucheur L; van Milgen J
[Ad] Endereço:UMR1348 PEGASE, INRA, 35590, Saint-Gilles, France.
[Ti] Título:Splanchnic tissues respond differently when piglets are offered a diet 30 % deficient in total sulfur amino acid for 10 days.
[So] Source:Eur J Nutr;55(7):2209-19, 2016 Oct.
[Is] ISSN:1436-6215
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: A deficient total sulfur amino acid (TSAA) supply has been reported to differently affect the amino acid composition of tissues, but limited information is available about its effects on the morphology and metabolic properties of splanchnic tissues. METHODS: The amino acid composition, protein metabolism, glutathione concentration of the liver, proximal and distal jejunum, ileum and kidneys, and intestinal architecture were compared in 42-day-old piglets pair-fed either a diet deficient (TSAA-; 28 % deficiency) or sufficient (TSAA+) in TSAA for 10 days. RESULTS: The supply of TSAA had no effect on tissue weights, but influenced the amino acid composition in a tissue-dependent manner. Compared with animals receiving diet TSAA+, the concentrations of Met and Ser were higher in liver protein of TSAA- animals while the Cys concentration in protein was lower in the liver but higher in the distal jejunum. The TSAA supply had no effect on protein synthesis and proteolytic activities of tissues. Villus width and surface, and crypt surface were lower in the proximal jejunum of TSAA- versus TSAA+ pigs. Crypt surface in the ileum of TSAA- pigs was higher. Pigs receiving diet TSAA- had lower GSH and GSSG concentrations in the liver and proximal jejunum, but the GSH/GSSG ratio was decreased only in the liver. CONCLUSIONS: A greater nutritional priority appears to be given to splanchnic tissues so that its growth and protein metabolism can be maintained when the TSAA supply is limiting. The amino acid composition, glutathione status, and intestinal mucosa architecture are affected in a tissue-dependent manner.
[Mh] Termos MeSH primário: Aminoácidos Sulfúricos/administração & dosagem
Aminoácidos Sulfúricos/deficiência
Ração Animal/análise
[Mh] Termos MeSH secundário: Aminoácidos/sangue
Animais
Calpaína/sangue
Cisteína/sangue
Dieta/veterinária
Glutationa/sangue
Mucosa Intestinal/efeitos dos fármacos
Mucosa Intestinal/metabolismo
Intestino Delgado/efeitos dos fármacos
Intestino Delgado/metabolismo
Rim/efeitos dos fármacos
Rim/metabolismo
Fígado/efeitos dos fármacos
Fígado/metabolismo
Metionina/sangue
Tamanho do Órgão/efeitos dos fármacos
Biossíntese de Proteínas/efeitos dos fármacos
Proteólise/efeitos dos fármacos
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Amino Acids, Sulfur); AE28F7PNPL (Methionine); EC 3.4.22.- (Calpain); GAN16C9B8O (Glutathione); K848JZ4886 (Cysteine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150904
[St] Status:MEDLINE
[do] DOI:10.1007/s00394-015-1031-x


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[PMID]:26122403
[Au] Autor:Ma W; Zhu J; Zeng X; Liu X; Thacker P; Qiao S
[Ad] Endereço:State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, China.
[Ti] Título:Estimation of the optimum standardized ileal digestible total sulfur amino acid to lysine ratio in late finishing gilts fed low protein diets supplemented with crystalline amino acids.
[So] Source:Anim Sci J;87(1):76-83, 2016 Jan.
[Is] ISSN:1740-0929
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:A total of 90 gilts were used to investigate the effects of various standard ileal digestible (SID) total sulfur amino acid (TSAA) to lysine (Lys) ratios on the performance and carcass characteristics of late finishing gilts receiving low crude protein (CP) diets supplemented with crystalline amino acids (CAA). Graded levels of crystalline methionine (Met) (0, 0.3, 0.5, 0.8 or 1.1 g/kg) were added to the basal diet to produce diets providing SID TSAA to Lys ratios of 0.48, 0.53, 0.58, 0.63 or 0.68. At the termination of the experiment, 30 gilts (one pig per pen) with an average body weight (BW) of 120 kg were killed to evaluate carcass traits. Increasing the SID TSAA to Lys ratio increased average daily gain (ADG) (linear and quadratic effect, P < 0.05), improved feed conversion ratio (FCR) (linear and quadratic effect, P < 0.05) and decreased serum urea nitrogen (SUN) concentration (linear and quadratic effect, P < 0.05) of finishing gilts. No effects were obtained for carcass traits. The optimum SID TSAA to Lys ratios to maximize ADG as well as to minimize FCR and SUN levels were 0.57, 0.58 and 0.53 using a linear-break point model and 0.64, 0.62 and 0.61 using a quadratic model.
[Mh] Termos MeSH primário: Aminoácidos Sulfúricos
Ração Animal
Fenômenos Fisiológicos da Nutrição Animal
Dieta com Restrição de Proteínas
Proteínas na Dieta/administração & dosagem
Lisina
Metionina/administração & dosagem
Suínos/fisiologia
Ganho de Peso
[Mh] Termos MeSH secundário: Ração Animal/economia
Animais
Nitrogênio da Ureia Sanguínea
Cristalização
Feminino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amino Acids, Sulfur); 0 (Dietary Proteins); AE28F7PNPL (Methionine); K3Z4F929H6 (Lysine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170116
[Lr] Data última revisão:
170116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150701
[St] Status:MEDLINE
[do] DOI:10.1111/asj.12398



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