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Pesquisa : D02.886.030.676.950 [Categoria DeCS]
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  1 / 124 MEDLINE  
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[PMID]:27883364
[Au] Autor:Song JH; Lee HR; Shim SM
[Ad] Endereço:Dept. of Food Science and Technology, Sejong Univ, 98 Gunja-dong, Gwangjin-gu, Seoul, 143-747, Republic of Korea.
[Ti] Título:Determination of S-methyl-L-methionine (SMM) from Brassicaceae Family Vegetables and Characterization of the Intestinal Transport of SMM by Caco-2 Cells.
[So] Source:J Food Sci;82(1):36-43, 2017 Jan.
[Is] ISSN:1750-3841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objectives of the current study were to determine S-methyl-L-methionine (SMM) from various Brassicaceae family vegetables by using validated analytical method and to characterize the intestinal transport mechanism of SMM by the Caco-2 cells. The SMM is well known to provide therapeutic activity in peptic ulcers. The amount of SMM from various Brassicaceae family vegetables ranged from 89.08 ± 1.68 µg/g to 535.98 ± 4.85 µg/g of dry weight by using validated ultra-performance liquid chromatography-electrospray ionization-mass spectrometry method. For elucidating intestinal transport mechanism, the cells were incubated with or without transport inhibitors, energy source, or a metabolic inhibitor. Phloridzin and verapamil as inhibitors of sodium glucose transport protein (SGLT1) and P-glycoprotein, respectively, were not responsible for cellular uptake of SMM. Glucose and sodium azide were not affected by the cellular accumulation of SMM. The efflux ratio of SMM was 0.26, implying that it is not effluxed through Caco-2 cells. The apparent coefficient permeability (P ) of SMM was 4.69 × 10 cm/s, indicating that it will show good oral absorption in in vivo.
[Mh] Termos MeSH primário: Intestinos/metabolismo
Verduras/metabolismo
Vitamina U/química
[Mh] Termos MeSH secundário: Subfamília B de Transportador de Cassetes de Ligação de ATP/metabolismo
Transporte Biológico
Brassicaceae
Células CACO-2
Cromatografia Líquida de Alta Pressão
Cromatografia Líquida
Glucose/química
Seres Humanos
Absorção Intestinal
Limite de Detecção
Espectrometria de Massas
Úlcera Péptica/metabolismo
Permeabilidade
Reprodutibilidade dos Testes
Azida Sódica/química
Transportador 1 de Glucose-Sódio/metabolismo
Espectrometria de Massas por Ionização por Electrospray
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ABCB1 protein, human); 0 (ATP Binding Cassette Transporter, Sub-Family B); 0 (SLC5A1 protein, human); 0 (Sodium-Glucose Transporter 1); 3485Y39925 (Vitamin U); 968JJ8C9DV (Sodium Azide); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161125
[St] Status:MEDLINE
[do] DOI:10.1111/1750-3841.13556


  2 / 124 MEDLINE  
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[PMID]:26674326
[Au] Autor:Son YR; Choi EH; Kim GT; Park TS; Shim SM
[Ad] Endereço:Department of Food Science and Technology, Sejong University, 98 Gunja-dong, Gwangjin-gu, Seoul, 143-747, Republic of Korea. soonmishim@sejong.ac.kr.
[Ti] Título:Bioefficacy of Graviola leaf extracts in scavenging free radicals and upregulating antioxidant genes.
[So] Source:Food Funct;7(2):861-71, 2016 Feb.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aims of this study were to determine bioactive components of Graviola leaf extracts and to examine the radical scavenging capacity, gene expression and transcription factors of antioxidant enzymes. Rutin, kaempferol-rutinoside, and vitamin U were identified from the steaming and 50% EtOH extracts of Graviola leaves. Graviola leaf extracts effectively scavenged peroxy and nitrogen radicals. 50% EtOH of Graviola leaves provided a 1-2.9 times higher trolox equivalent than the steaming extract. It also had a higher VCEAC. Graviola leaf extracts reduced the generation of reactive oxygen species (ROS) induced by H2O2 in a dose-dependent manner. The 50% EtOH extract of Graviola leaves upregulated SOD1 and Nrf2, but catalase and HMOX1 were not altered by the 50% EtOH extract of Graviola leaves.
[Mh] Termos MeSH primário: Annona/química
Antioxidantes/metabolismo
Extratos Vegetais/farmacologia
Folhas de Planta/química
Regulação para Cima
[Mh] Termos MeSH secundário: Catalase/genética
Catalase/metabolismo
Heme Oxigenase-1/genética
Heme Oxigenase-1/metabolismo
Células Hep G2
Seres Humanos
Peróxido de Hidrogênio/metabolismo
Quempferóis/análise
Quempferóis/farmacologia
Fator 2 Relacionado a NF-E2/genética
Fator 2 Relacionado a NF-E2/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Rutina/análise
Rutina/farmacologia
Superóxido Dismutase-1/genética
Superóxido Dismutase-1/metabolismo
Fatores de Transcrição/genética
Fatores de Transcrição/metabolismo
Vitamina U/análise
Vitamina U/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Kaempferols); 0 (NF-E2-Related Factor 2); 0 (NFE2L2 protein, human); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 0 (SOD1 protein, human); 0 (Transcription Factors); 3485Y39925 (Vitamin U); 5G06TVY3R7 (Rutin); 731P2LE49E (kaempferol); BBX060AN9V (Hydrogen Peroxide); EC 1.11.1.6 (Catalase); EC 1.14.14.18 (HMOX1 protein, human); EC 1.14.14.18 (Heme Oxygenase-1); EC 1.15.1.1 (Superoxide Dismutase-1)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151218
[St] Status:MEDLINE
[do] DOI:10.1039/c5fo01258a


  3 / 124 MEDLINE  
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[PMID]:25802006
[Au] Autor:Gezginci-Oktayoglu S; Turkyilmaz IB; Ercin M; Yanardag R; Bolkent S
[Ad] Endereço:Faculty of Science, Department of Biology, Istanbul University, 34134, Vezneciler, Istanbul, Turkey. selgez@istanbul.edu.tr.
[Ti] Título:Vitamin U has a protective effect on valproic acid-induced renal damage due to its anti-oxidant, anti-inflammatory, and anti-fibrotic properties.
[So] Source:Protoplasma;253(1):127-35, 2016 Jan.
[Is] ISSN:1615-6102
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:The aim of present study was to investigate the effect of vitamin U (vit U, S-methylmethionine) on oxidative stress, inflammation, and fibrosis within the context of valproic acid (VPA)-induced renal damage. In this study, female Sprague Dawley rats were randomly divided into four groups: Group I consisted of intact animals, group II was given vit U (50 mg/kg/day, by gavage), group III was given VPA (500 mg/kg/day, intraperitonally), and group IV was given VPA + vit U. The animals were treated by vit U 1 h prior to treatment with VPA every day for 15 days. The following results were obtained in vit U + VPA-treated rats: (i) the protective effect of vit U on renal damage was shown by a significant decrease in histopathological changes and an increase in Na(+)/K(+)-ATPase activity; (ii) anti-oxidant property of vit U was demonstrated by a decrease in malondialdehyde levels and xanthine oxidase activity and an increase in glutathione levels, catalase and superoxide dismutase activities; (iii) anti-inflammatory property of vit U was demonstrated by a decrease in tumor necrosis factor-α, interleukin-1ß, monocyte chemoattractant protein-1 levels, and adenosine deaminase activity; (iv) anti-fibrotic effect of vit U was shown by a decrease in transforming growth factor-ß, collagen-1 levels, and arginase activity. Collectively, these data show that VPA is a promoter of inflammation, oxidative stress, and fibrosis which resulted in renal damage. Vit U can be proposed as a potential candidate for preventing renal damage which arose during the therapeutic usage of VPA.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Antioxidantes/farmacologia
Rim/patologia
Ácido Valproico/efeitos adversos
Vitamina U/farmacologia
[Mh] Termos MeSH secundário: Animais
Western Blotting
Catalase/metabolismo
Colágeno Tipo I/metabolismo
Creatinina/sangue
Feminino
Fibrose
Glutationa/metabolismo
Glutationa Transferase/metabolismo
Immunoblotting
Inflamação/patologia
Rim/efeitos dos fármacos
Peroxidação de Lipídeos/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Ratos Sprague-Dawley
Superóxido Dismutase/metabolismo
Fator de Crescimento Transformador beta1/metabolismo
Ureia/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Collagen Type I); 0 (Transforming Growth Factor beta1); 3485Y39925 (Vitamin U); 614OI1Z5WI (Valproic Acid); 8W8T17847W (Urea); AYI8EX34EU (Creatinine); EC 1.11.1.6 (Catalase); EC 1.15.1.1 (Superoxide Dismutase); EC 2.5.1.18 (Glutathione Transferase); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150325
[St] Status:MEDLINE
[do] DOI:10.1007/s00709-015-0796-3


  4 / 124 MEDLINE  
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[PMID]:26827446
[Au] Autor:Khrystych TN; Gontsaryuk DA
[Ti] Título:[ABOUT CO-OCCURRENCE OF CRHONIC PANCREATITIS WITH GASTRODUODENAL DISEASES].
[So] Source:Lik Sprava;(3-4):87-94, 2015 Apr-Jun.
[Is] ISSN:1019-5297
[Cp] País de publicação:Ukraine
[La] Idioma:rus
[Ab] Resumo:The article summarizes clinical features of the course when chronic pancreatitis goes in combination with diseases of gastroduodenal and hepatobiliary systems and features of functional and morphological changes. The article also represents justification of need to include the combined medicine Doktovit (combination of Dexpanthenol and S-methylmethionine) into complex treatment of the pathology, describes mechanism of its gastro protective and reparative action.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Duodenopatias/fisiopatologia
Hepatopatias/fisiopatologia
Pancreatite Crônica/fisiopatologia
Substâncias Protetoras/uso terapêutico
Gastropatias/fisiopatologia
[Mh] Termos MeSH secundário: Duodenopatias/complicações
Duodenopatias/tratamento farmacológico
Duodenopatias/metabolismo
Heme/análogos & derivados
Heme/uso terapêutico
Seres Humanos
Hepatopatias/complicações
Hepatopatias/tratamento farmacológico
Hepatopatias/metabolismo
Meglumina/análogos & derivados
Meglumina/uso terapêutico
Pancreatite Crônica/complicações
Pancreatite Crônica/tratamento farmacológico
Pancreatite Crônica/metabolismo
Ácido Pantotênico/uso terapêutico
Gastropatias/complicações
Gastropatias/tratamento farmacológico
Gastropatias/metabolismo
Succinatos/uso terapêutico
Vitamina U/uso terapêutico
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antioxidants); 0 (Protective Agents); 0 (Reamberin); 0 (Succinates); 19F5HK2737 (Pantothenic Acid); 3485Y39925 (Vitamin U); 42VZT0U6YR (Heme); 63748-11-8 (Actovegin); 6HG8UB2MUY (Meglumine)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160202
[St] Status:MEDLINE


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[PMID]:26225962
[Au] Autor:Kim WS; Seo HM; Kim WK; Choi JS; Kim I; Sung JH
[Ad] Endereço:Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 110-746, Korea. susini@naver.com.
[Ti] Título:The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin.
[So] Source:Int J Mol Sci;16(8):17088-100, 2015 Jul 28.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:S-Methylmethionine sulfonium (SMMS) was reported to have wound-healing effects; we therefore have investigated the photoprotective effect of SMMS in the present study. SMMS increased the viability of keratinocyte progenitor cells (KPCs) and human dermal fibroblasts (hDFs) following ultraviolet B (UVB) irradiation, and reduced the UVB-induced apoptosis in these cells. SMMS increased the phosphorylation of extracellular signal-regulated kinases (ERK), and the inhibitor of the mitogen-activated protein kinase pathway significantly decreased the SMMS-induced viability of KPCs and hDFs. In addition, SMMS attenuated the UVB-induced reactive oxygen species (ROS) generation in KPCs and hDFs. SMMS induced the collagen synthesis and reduced the matrix metalloproteinase-1 expression in UVB-irradiated hDFs. In animal studies, application of 5% and 10% SMMS before and after UVB-irradiation significantly decreased the UVB-induced erythema index and depletion of Langerhans cells. In summary, SMMS protects KPCs and hDFs from UVB irradiation, and reduces UVB-induced skin erythema and immune suppression. Therefore, SMMS can be used as a cosmetic raw material, and protect skin from UVB.
[Mh] Termos MeSH primário: Eritema/tratamento farmacológico
Pele/efeitos dos fármacos
Protetores Solares/farmacologia
Vitamina U/farmacologia
Vitaminas/farmacologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Colágeno/genética
Colágeno/metabolismo
Eritema/etiologia
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Fibroblastos/efeitos dos fármacos
Fibroblastos/metabolismo
Fibroblastos/efeitos da radiação
Seres Humanos
Queratinócitos/efeitos dos fármacos
Queratinócitos/metabolismo
Queratinócitos/efeitos da radiação
Metaloproteinase 1 da Matriz/metabolismo
Ratos
Espécies Reativas de Oxigênio/metabolismo
Pele/efeitos da radiação
Protetores Solares/uso terapêutico
Raios Ultravioleta/efeitos adversos
Vitamina U/uso terapêutico
Vitaminas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Reactive Oxygen Species); 0 (Sunscreening Agents); 0 (Vitamins); 3485Y39925 (Vitamin U); 9007-34-5 (Collagen); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); EC 3.4.24.7 (Matrix Metalloproteinase 1)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:150929
[Lr] Data última revisão:
150929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150731
[St] Status:MEDLINE
[do] DOI:10.3390/ijms160817088


  6 / 124 MEDLINE  
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[PMID]:25504687
[Au] Autor:Tunali S; Kahraman S; Yanardag R
[Ad] Endereço:Department of Chemistry, Faculty of Engineering, Istanbul University, Avcilar, Istanbul, Turkey.
[Ti] Título:Vitamin U, a novel free radical scavenger, prevents lens injury in rats administered with valproic acid.
[So] Source:Hum Exp Toxicol;34(9):904-10, 2015 Sep.
[Is] ISSN:1477-0903
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Valproic acid (2-propyl-pentanoic acid, VPA) is the most widely prescribed antiepileptic drug due to its ability to treat a broad spectrum of seizure types. VPA exhibits various side effects such as organ toxicity, teratogenicity, and visual disturbances. S-Methylmethioninesulfonium is a derivative of the amino acid methionine and it is widely referred to as vitamin U (Vit U). This study was aimed to investigate the effects of Vit U on lens damage parameters of rats exposed to VPA. Female Sprague Dawley rats were divided into four groups. Group I comprised control animals. Group II included control rats supplemented with Vit U (50 mg/kg/day) for 15 days. Group III was given only VPA (500 mg/kg/day) for 15 days. Group IV was given VPA + Vit U (in same dose and time). Vit U was given to rats by gavage and VPA was given intraperitoneally. On the 16th day of experiment, all the animals which were fasted overnight were killed. Lens was taken from animals, homogenized in 0.9% saline to make up to 10% (w/v) homogenate. The homogenates were used for protein, glutathione, lipid peroxidation levels, and antioxidant enzymes activities. Lens lipid peroxidation levels and aldose reductase and sorbitol dehydrogenase activities were increased in VPA group. On the other hand, glutathione levels, superoxide dismutase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, and paraoxonase activities were decreased in VPA groups. Treatment with Vit U reversed these effects. This study showed that Vit U exerted antioxidant properties and may prevent lens damage caused by VPA.
[Mh] Termos MeSH primário: Anticonvulsivantes/toxicidade
Depuradores de Radicais Livres/uso terapêutico
Doenças do Cristalino/induzido quimicamente
Doenças do Cristalino/prevenção & controle
Ácido Valproico/toxicidade
Vitamina U/uso terapêutico
Vitaminas/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Feminino
Cristalino/patologia
Peroxidação de Lipídeos/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticonvulsants); 0 (Antioxidants); 0 (Free Radical Scavengers); 0 (Vitamins); 3485Y39925 (Vitamin U); 614OI1Z5WI (Valproic Acid)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:150819
[Lr] Data última revisão:
150819
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141216
[St] Status:MEDLINE
[do] DOI:10.1177/0960327114561665


  7 / 124 MEDLINE  
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[PMID]:25488426
[Au] Autor:Frank A; Cohen H; Hoffman D; Amir R
[Ad] Endereço:Laboratory of Plant Science, Migal, Galilee Research Institute Ltd., P.O.B. 831, 11016, Kiryat Shmona, Israel.
[Ti] Título:Methionine and S-methylmethionine exhibit temporal and spatial accumulation patterns during the Arabidopsis life cycle.
[So] Source:Amino Acids;47(3):497-510, 2015 Mar.
[Is] ISSN:1438-2199
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Methionine is a nutritionally essential sulfur-containing amino acid found at low levels in plant tissues. Yet, the factors that regulate its synthesis and accumulation in seeds are not fully known. Recent genetic studies demonstrate that Arabidopsis seeds are able to synthesize methionine de novo through the aspartate family pathway similarly to vegetative tissues; however, additional biochemical studies suggest that the S-methylmethionine (SMM) cycle also plays a major role in methionine synthesis in seeds. To better understand the contribution of these two pathways to methionine synthesis, we have sampled various vegetative and reproductive tissues during the Arabidopsis life cycle and determined the contents of soluble and protein-incorporated methionine, SMM, as well as the expression levels of the key genes involved in these two pathways. Our results strengthen the hypothesis that SMM that is produced in the rosette leaves from methionine contributes to methionine accumulation in seeds. However, the SMM cycle may have additional functions in plant tissues since its key genes were expressed in all of the examined tissues, although at different rates. The accumulation patterns of soluble and protein-incorporated methionine during the Arabidopsis life cycle were found to be similar to most of the other amino acids, especially to those belonging to the branched-chain and aromatic amino acids that are produced in chloroplasts together with methionine. This indicates that similar factors regulate the levels of amino acids during development.
[Mh] Termos MeSH primário: Arabidopsis/metabolismo
Folhas de Planta/metabolismo
Vitamina U/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
3485Y39925 (Vitamin U)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150213
[Lr] Data última revisão:
150213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141210
[St] Status:MEDLINE
[do] DOI:10.1007/s00726-014-1881-1


  8 / 124 MEDLINE  
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[PMID]:25090616
[Au] Autor:Morisaki A; Yamada N; Yamanaka S; Matsui K
[Ad] Endereço:Graduate School of Medicine (Agriculture) and Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University , Yamaguchi 753-8515, Japan.
[Ti] Título:Dimethyl sulfide as a source of the seaweed-like aroma in cooked soybeans and correlation with its precursor, S-methylmethionine (vitamin U).
[So] Source:J Agric Food Chem;62(33):8289-94, 2014 Aug 20.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Among the soybean germplasm in Japan, two varieties, Nishiyamahitashi 98-5 (NH) and Shinanokurakake (SKK), have an intense seaweed-like flavor after cooking. Gas-liquid chromatography with mass spectrometry (GC-MS) indicated that a significant amount (11.5 ± 3.46 µg g(-1) for NH and 6.66 ± 0.91 µg g(-1) for SKK) of dimethyl sulfide (DMS) was formed after heat treatment. DMS is formed from S-methylmethionine (SMM, vitamin U). SMM was detected in all soybean varieties examined here, but its concentration in NH and SKK seeds was >100-fold higher than in the other varieties and ranged from 75 to 290 µg g(-1). The SMM content and the ability to form DMS upon heat treatment correlated among them. The plumes and radicles contained SMM exclusively. This is the first report of soybean varieties containing SMM at a level equivalent to or higher than that in vegetables known to contain high levels of SMM, for example, turnip, cabbage, and celery.
[Mh] Termos MeSH primário: Aromatizantes/análise
Feijão de Soja/química
Sulfetos/análise
Vitamina U/análise
[Mh] Termos MeSH secundário: Culinária
Japão
Sementes/química
Feijão de Soja/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Flavoring Agents); 0 (Sulfides); 3485Y39925 (Vitamin U); QS3J7O7L3U (dimethyl sulfide)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:141030
[Lr] Data última revisão:
141030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140805
[St] Status:MEDLINE
[do] DOI:10.1021/jf501614j


  9 / 124 MEDLINE  
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[PMID]:24825818
[Au] Autor:Juhász C; Dwivedi S; Kamson DO; Michelhaugh SK; Mittal S
[Ti] Título:Comparison of amino acid positron emission tomographic radiotracers for molecular imaging of primary and metastatic brain tumors.
[So] Source:Mol Imaging;13, 2014.
[Is] ISSN:1536-0121
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Positron emission tomography (PET) is an imaging technology that can detect and characterize tumors based on their molecular and biochemical properties, such as altered glucose, nucleoside, or amino acid metabolism. PET plays a significant role in the diagnosis, prognostication, and treatment of various cancers, including brain tumors. In this article, we compare uptake mechanisms and the clinical performance of the amino acid PET radiotracers (l-[methyl-11C]methionine [MET], 18F-fluoroethyl-tyrosine [FET], 18F-fluoro-l-dihydroxy-phenylalanine [FDOPA], and 11C-alpha-methyl-l-tryptophan [AMT]) most commonly used for brain tumor imaging. First, we discuss and compare the mechanisms of tumoral transport and accumulation, the basis of differential performance of these radioligands in clinical studies. Then we summarize studies that provided direct comparisons among these amino acid tracers and to clinically used 2-deoxy-2[18F]fluoro-d-glucose [FDG] PET imaging. We also discuss how tracer kinetic analysis can enhance the clinical information obtained from amino acid PET images. We discuss both similarities and differences in potential clinical value for each radioligand. This comparative review can guide which radiotracer to favor in future clinical trials aimed at defining the role of these molecular imaging modalities in the clinical management of brain tumor patients.
[Mh] Termos MeSH primário: Aminoácidos/farmacocinética
Neoplasias Encefálicas/diagnóstico por imagem
Metástase Neoplásica/diagnóstico por imagem
Compostos Radiofarmacêuticos
[Mh] Termos MeSH secundário: Neoplasias Encefálicas/patologia
Radioisótopos de Carbono
Radioisótopos de Flúor
Glucose/metabolismo
Seres Humanos
Metástase Neoplásica/patologia
Tomografia por Emissão de Pósitrons
Vitamina U
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Amino Acids); 0 (Carbon Radioisotopes); 0 (Fluorine Radioisotopes); 0 (Radiopharmaceuticals); 3485Y39925 (Vitamin U); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140515
[St] Status:MEDLINE
[do] DOI:10.2310/7290.2014.00015


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[PMID]:24514152
[Au] Autor:Sato D; Sugimoto M; Akashi H; Tomita M; Soga T
[Ad] Endereço:Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan.
[Ti] Título:Comparative metabolite profiling of foxglove aphids (Aulacorthum solani Kaltenbach) on leaves of resistant and susceptible soybean strains.
[So] Source:Mol Biosyst;10(4):909-15, 2014 Apr.
[Is] ISSN:1742-2051
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Aphid infestations can cause severe decreases in soybean (Glycine max [L.] Merr.) yield. Since planting aphid-resistant soybean strains is a promising approach for pest control, understanding the resistance mechanisms employed by aphids is of considerable importance. We compared aphid resistance in seven soybean strains and found that strain Tohoku149 was the most resistant to the foxglove aphid, Aulacorthum solani Kaltenbach. We subsequently analyzed the metabolite profiles of aphids cultured on the leaves of resistant and susceptible soybean strains using capillary electrophoresis-time-of-flight mass spectrometry. Our findings showed that the metabolite profiles of several amino acids, glucose 6-phosphate, and components of the tricarboxylic acid cycle were similar in aphids reared on Tohoku149 leaves and in aphids maintained under conditions of starvation, suggesting that Tohoku149 is more resistant to aphid feeding. Compared to susceptible strains, we also found that two methylated metabolites, S-methylmethionine and trigonelline, were either not detected or decreased in aphids reared on Tohoku149 plants. Since these metabolites function as important sulfur transporters in phloem sap and osmoprotectants involved in salt and drought stress, respectively, aphid-resistance is considered to be related to sulfur metabolism and methylation. These results contribute to an increase in our understanding of soybean aphid resistance mechanisms at the molecular level.
[Mh] Termos MeSH primário: Alcaloides/metabolismo
Afídeos/metabolismo
Folhas de Planta/imunologia
Feijão de Soja/imunologia
Vitamina U/metabolismo
[Mh] Termos MeSH secundário: Alcaloides/análise
Aminoácidos/metabolismo
Animais
Transporte Biológico
Metabolismo Energético
Perfilação da Expressão Gênica
Espectrometria de Massas
Metilação
Controle de Pragas
Feijão de Soja/classificação
Enxofre/metabolismo
Vitamina U/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Amino Acids); 3485Y39925 (Vitamin U); 3NQ9N60I00 (trigonelline); 70FD1KFU70 (Sulfur)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:140305
[Lr] Data última revisão:
140305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140212
[St] Status:MEDLINE
[do] DOI:10.1039/c3mb70595a



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