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[PMID]:28458430
[Au] Autor:Adel M; Sadegh AB; Arizza V; Abbasi H; Inguglia L; Saravi HN
[Ad] Endereço:Department of Aquatic Animal Health and Diseases, Iranian Fisheries Science Research Institute, Agricultural Research Education and Extension Organization, Tehran, Iran.
[Ti] Título:Anesthetic efficacy of ketamine-diazepam, ketamine-xylazine, and ketamine-acepromazine in Caspian Pond turtles ( ).
[So] Source:Indian J Pharmacol;49(1):93-97, 2017 Jan-Feb.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The objective of this study was to assess the efficacy of different anesthetic drug combinations on the Caspian Pond turtles ( ). SUBJECTS AND METHODS: Three groups of the Caspian Pond turtles ( = 6) were anesthetized with three different drug combinations. Initially, a pilot study was conducted to determine the best drug doses for the anesthetization of the turtles, and according to these results, ketamine-diazepam (120 mg/kg ketamine hydrochloride [5%] and 2 mg/kg diazepam [5%]), ketamine-acepromazine (120 mg/kg ketamine hydrochloride [5%] and 1 mg/kg acepromazine [1%]), and ketamine-xylazine (120 mg/kg ketamine hydrochloride [5%] and 1 mg/kg xylazine [2%]) were injected intramuscularly. The onset times of anesthetization and the recovery time were measured. Statistical analysis of the data was performed using one-way analysis of variance followed by -tests, and < 0.05 was considered statistically significant. RESULTS: There were statistically significant differences in the mean of the onset times of anesthesia and recovery time among the three drug combinations depending on the treatment used. The onset of anesthesia of the animals treated with the ketamine-diazepam combination was 60% and 42% shorter, for male and female turtles, respectively, compared to that obtained with the ketamine-acepromazine combination and 64% (male turtles) and 50% (female turtles) shorter than that obtained with the ketamine-xylazine combination. Further, the recovery time, in male turtles, was 17% shorter in animals treated with the first drug combination than those treated with the ketamine-acepromazine combination and 37% shorter than those treated with the ketamine-xylazine combination. The recovery time, in female turtles, did not seem to be significantly different among treatments. CONCLUSIONS: The study showed that the ketamine-diazepam drug combination is the anesthetic combination with the fastest onset time and shortest recovery time.
[Mh] Termos MeSH primário: Acepromazina/administração & dosagem
Diazepam/administração & dosagem
Ketamina/administração & dosagem
Xilazina/administração & dosagem
[Mh] Termos MeSH secundário: Acepromazina/farmacologia
Período de Recuperação da Anestesia
Anestésicos/administração & dosagem
Anestésicos/farmacologia
Animais
Diazepam/farmacologia
Relação Dose-Resposta a Droga
Feminino
Injeções Intramusculares
Ketamina/farmacologia
Masculino
Projetos Piloto
Fatores Sexuais
Fatores de Tempo
Tartarugas
Xilazina/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics); 2KFG9TP5V8 (Xylazine); 54EJ303F0R (Acepromazine); 690G0D6V8H (Ketamine); Q3JTX2Q7TU (Diazepam)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.201023


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[PMID]:28410672
[Au] Autor:Raidal SL; Burnheim K; Evans D; Hughes KJ
[Ad] Endereço:School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, Australia. Electronic address: sraidal@csu.edu.au.
[Ti] Título:Effects of sedation and salbutamol administration on hyperpnoea and tidal breathing spirometry in healthy horses.
[So] Source:Vet J;222:22-28, 2017 Apr.
[Is] ISSN:1532-2971
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Sedation is often required to perform pulmonary function testing (PFT) in horses, but drug effects may influence respiratory function. The current study was designed to characterise the effects of sedation and bronchodilator administration on absolute and relative indices of pulmonary function during eupnoeic respiration and carbon dioxide-induced hyperpnoea (rebreathing) in healthy horses using a pneumotachographic spirometry system. Sedation with acetylpromazine (ACP), xylazine, or both drugs in combination was associated with significant reductions in respiratory frequency, minute ventilation and peak airflows during eupnoeic respiration. Peak expiratory airflow occurred later in the respiratory cycle than was observed in untreated horses, and expiratory relative flow-time indices were also affected during eupnoeic respiration. Rebreathing attenuated the effects of sedation on indices of pulmonary function, suggesting that future studies should consider the use of induced hyperpnoea as part of the spirometry protocol. Based on the finding that all sedative agents had some effect on eupnoeic respiration, albeit least pronounced with ACP, the latter drug should be considered for sedation of horses undergoing PFT. Salbutamol increased peak inspiratory flow during eupnoeic respiration in healthy horses.
[Mh] Termos MeSH primário: Albuterol/farmacologia
Broncodilatadores/farmacologia
Cavalos
Hipnóticos e Sedativos/farmacologia
Respiração/efeitos dos fármacos
[Mh] Termos MeSH secundário: Acepromazina/farmacologia
Animais
Feminino
Estudos Prospectivos
Testes de Função Respiratória/veterinária
Espirometria/veterinária
Xilazina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Bronchodilator Agents); 0 (Hypnotics and Sedatives); 2KFG9TP5V8 (Xylazine); 54EJ303F0R (Acepromazine); QF8SVZ843E (Albuterol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170416
[St] Status:MEDLINE


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[PMID]:28140649
[Au] Autor:Santarelli G; López JT; Del Palacio JF
[Ti] Título:Effects of a combination of acepromazine maleate and butorphanol tartrate on conventional and two-dimensional speckle tracking echocardiography in healthy dogs.
[So] Source:Am J Vet Res;78(2):158-167, 2017 Feb.
[Is] ISSN:1943-5681
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE To determine effects of a combination of acepromazine maleate and butorphanol tartrate on conventional echocardiographic variables and on strain values obtained by use of 2-D speckle tracking echocardiography (STE) in healthy dogs. ANIMALS 18 healthy medium- and large-size adult dogs. PROCEDURES Transthoracic echocardiographic examination (2-D, M-mode, color flow, spectral Doppler, and tissue Doppler ultrasonography) and high-definition oscillometric blood pressure measurement were performed before and after dogs were sedated by IM administration of a combination of acepromazine (0.02 mg/kg) and butorphanol (0.2 mg/kg). Adequacy of sedation for echocardiographic examination was evaluated. Circumferential and longitudinal global and segmental strains of the left ventricle (LV) were obtained with 2-D STE by use of right parasternal short-axis and left parasternal apical views. Values before and after sedation were compared. RESULTS The sedation combination provided adequate immobilization to facilitate echocardiographic examination. Heart rate and mean and diastolic blood pressures decreased significantly after dogs were sedated. A few conventional echocardiographic variables differed significantly from baseline values after sedation, including decreased end-diastolic LV volume index, peak velocity of late diastolic transmitral flow, and late diastolic septal mitral and tricuspid annulus velocities, increased ejection time, and increased mitral ratio of peak early to late diastolic filling velocity; global strain values were not affected, but 1 segmental (apical lateral) strain value decreased significantly. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that acepromazine and butorphanol at the doses used in this study provided sedation adequate to facilitate echocardiography, with only mild influences on conventional and 2-D STE variables.
[Mh] Termos MeSH primário: Acepromazina/farmacologia
Butorfanol/farmacologia
Sedação Consciente/veterinária
Cães/fisiologia
Hipnóticos e Sedativos/farmacologia
[Mh] Termos MeSH secundário: Animais
Combinação de Medicamentos
Ecocardiografia/veterinária
Feminino
Frequência Cardíaca/efeitos dos fármacos
Masculino
Função Ventricular Esquerda/efeitos dos fármacos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Hypnotics and Sedatives); 54EJ303F0R (Acepromazine); QV897JC36D (Butorphanol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.2460/ajvr.78.2.158


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[PMID]:28126600
[Au] Autor:Lizarraga I; Castillo-Alcala F; Robinson LS
[Ad] Endereço:Department of Biomedical Sciences, Ross University School of Veterinary Medicine, P.O. Box 334, Basseterre, Saint Kitts and Nevis. Electronic address: madrigal@unam.mx.
[Ti] Título:Sedative and mechanical antinociceptive effects of four dosages of romifidine administered intravenously to donkeys.
[So] Source:Res Vet Sci;112:46-51, 2017 Jun.
[Is] ISSN:1532-2661
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although romifidine is commonly used to provide sedation and analgesia for the facilitation of clinical procedures in donkeys, limited scientific information is available for this drug in this species. This randomized, controlled, crossover, Latin-square, blinded study compared the sedative and antinociceptive effects of four dosages of romifidine (40, 60, 80, and 100µg/kg IV; R40, R60, R80, and R100, respectively), acepromazine (0.1mg/kg IV; ACE) and saline (0.9%, 5mL IV) by assigning sedation scores (SS) and measuring head heights above ground (HHAG) and mechanical nociceptive thresholds (MNT) in donkeys. Areas under the curve (AUC) from 0 to 30, 30-60, 60-120, and 120-180min after administration were computed for SS, HHAG, and MNT and compared among treatments. Romifidine and ACE, but not saline, induced clinical signs of sedation. SS-AUC for R60, R80 and R100, and SS-AUC for R100 were higher than corresponding values for saline. HHAG-AUC for R40 and R80, and HHAG-AUC for R40, R60, R80 and R100 were smaller than for saline. HHAG-AUC for R100 were also smaller than those for ACE. Romifidine, but not saline or ACE, increased MNT. MNT-AUC and MNT-AUC for R40, R60, R80 and R100, and MNT-AUC for R80 and R100 were higher than corresponding values for saline and ACE. MNT-AUC for R100 were higher than for all other romifidine treatments. In donkeys, the degree of sedation was similar for the four dosages of romifidine, but antinociception was dose-dependent.
[Mh] Termos MeSH primário: Equidae
Imidazóis/farmacologia
Nociceptividade/efeitos dos fármacos
Dor/veterinária
[Mh] Termos MeSH secundário: Acepromazina/administração & dosagem
Acepromazina/farmacologia
Administração Intravenosa
Analgésicos/farmacologia
Anestésicos/administração & dosagem
Anestésicos/farmacologia
Animais
Antipsicóticos/administração & dosagem
Antipsicóticos/farmacologia
Área Sob a Curva
Sedação Consciente/veterinária
Estudos Cross-Over
Relação Dose-Resposta a Droga
Quimioterapia Combinada
Feminino
Hipnóticos e Sedativos
Imidazóis/administração & dosagem
Masculino
Dor/prevenção & controle
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anesthetics); 0 (Antipsychotic Agents); 0 (Hypnotics and Sedatives); 0 (Imidazoles); 54EJ303F0R (Acepromazine); 876351L05K (romifidine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE


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[PMID]:27901396
[Au] Autor:Schier MF; Raisis AL; Secombe CJ; Hosgood G; Musk GC; Lester GD
[Ti] Título:Effects of dobutamine hydrochloride on cardiovascular function in horses anesthetized with isoflurane with or without acepromazine maleate premedication.
[So] Source:Am J Vet Res;77(12):1318-1324, 2016 Dec.
[Is] ISSN:1943-5681
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE To determine the effects of acepromazine maleate premedication on cardiovascular function before and after infusion of dobutamine hydrochloride for 30 minutes in isoflurane-anesthetized horses. ANIMALS 6 healthy adult horses. PROCEDURES Each horse was anesthetized once following premedication with acepromazine (0.02 mg/kg, IV) administered 30 minutes prior to anesthetic induction (ACP+ treatment) and once without premedication (ACP- treatment). Anesthesia was induced with IV administration of xylazine hydrochloride (0.8 mg/kg), ketamine hydrochloride (2.2 mg/kg), and diazepam (0.08 mg/kg). Horses were positioned in right lateral recumbency, and anesthesia was maintained via inhalation of isoflurane delivered in oxygen. End-tidal isoflurane concentration was adjusted to achieve a target mean arterial blood pressure of 60 mm Hg (interquartile range [25th to 75th percentile], 57 to 63 mm Hg) for at least 15 minutes. Cardiac index, oxygen delivery index, and femoral arterial blood flow indices were determined 60 minutes after anesthetic induction (baseline). Dobutamine was then infused to achieve a target mean arterial blood pressure of 80 mm Hg (interquartile range, 76 to 80 mm Hg). Data collection was repeated 30 minutes after the start of dobutamine infusion for comparison with baseline values. RESULTS Complete data sets were available from 5 of the 6 horses. Dobutamine administration resulted in significant increases in oxygen delivery and femoral arterial blood flow indices but no significant change in cardiac index for each treatment. However, at baseline or 30 minutes after the start of dobutamine infusion, findings for the ACP+ and ACP- treatments did not differ. CONCLUSIONS AND CLINICAL RELEVANCE In isoflurane-anesthetized horses, dobutamine administration increased oxygen delivery and femoral arterial blood flow indices, but these changes were unaffected by premedication with acepromazine.
[Mh] Termos MeSH primário: Cardiotônicos/farmacologia
Dobutamina/farmacologia
Frequência Cardíaca/efeitos dos fármacos
Cavalos/fisiologia
[Mh] Termos MeSH secundário: Acepromazina/administração & dosagem
Anestesia/veterinária
Anestésicos Inalatórios/administração & dosagem
Animais
Antipsicóticos/administração & dosagem
Pressão Sanguínea/efeitos dos fármacos
Cardiotônicos/administração & dosagem
Dobutamina/administração & dosagem
Esquema de Medicação
Hemodinâmica/efeitos dos fármacos
Infusões Intravenosas/veterinária
Isoflurano/administração & dosagem
Masculino
Pré-Medicação/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); 0 (Antipsychotic Agents); 0 (Cardiotonic Agents); 3S12J47372 (Dobutamine); 54EJ303F0R (Acepromazine); CYS9AKD70P (Isoflurane)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161201
[St] Status:MEDLINE


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[PMID]:27810209
[Au] Autor:Amendt HL; Siedenburg JS; Steffensen N; Söbbeler FJ; Schütter A; Tünsmeyer J; Rohn K; Kästner SB; Tipold A; Stein VM
[Ad] Endereço:Department of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany.
[Ti] Título:Transcranial magnetic stimulation with acepromazine or dexmedetomidine in combination with levomethadone/fenpipramide in healthy Beagle dogs.
[So] Source:Vet J;217:40-42, 2016 Nov.
[Is] ISSN:1532-2971
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to evaluate the influence of two sedation protocols on transcranial magnetic motor evoked potentials (TMMEPs) after transcranial magnetic stimulation in medium sized dogs. Onset latencies and peak-to-peak amplitudes, elicited in the extensor carpi radialis and cranial tibial muscles, were analysed in 10 healthy Beagles that received either acepromazine or dexmedetomidine in combination with levomethadone/fenpipramide, in a crossover design. Similar TMMEP recordings could be made using both sedation protocols at 80-90% stimulation intensity; however, there were significantly shorter onset latencies with the acepromazine-levomethadone/fenpipramide protocol at 100% stimulation intensity. Reference values were established and it was concluded that both drug combinations are feasible for measuring TMMEPs in medium sized dogs.
[Mh] Termos MeSH primário: Sedação Consciente/veterinária
Cães
Potencial Evocado Motor/efeitos dos fármacos
Hipnóticos e Sedativos/farmacologia
Estimulação Magnética Transcraniana/veterinária
[Mh] Termos MeSH secundário: Acepromazina/farmacologia
Analgésicos Opioides/farmacologia
Animais
Estudos Cross-Over
Dexmedetomidina/farmacologia
Ácidos Difenilacéticos/farmacologia
Valores de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Diphenylacetic Acids); 0 (Hypnotics and Sedatives); 54EJ303F0R (Acepromazine); 67VB76HONO (Dexmedetomidine); 88445508X3 (fenpipramide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE


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[PMID]:27733788
[Au] Autor:Monteiro ER; Lobo RB; Nunes JS; Rangel JP; Bitti FS
[Ad] Endereço:School of Veterinary Medicine, University of Vila Velha, Vila Velha, ES, Brazil 29102-920 (Monteiro, Lobo, Nunes Jr, Rangel, Bitti).
[Ti] Título:Tramadol does not enhance sedation induced by acepromazine in dogs.
[So] Source:Can J Vet Res;80(4):323-328, 2016 Oct.
[Is] ISSN:1928-9022
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:The sedative effect of acepromazine combined with 2 doses of tramadol [3 and 5 mg/kg body weight (BW)] was compared with the sedative effect of acepromazine alone in dogs and the effects of each sedative protocol on cardiorespiratory variables were examined. This was a prospective, randomized, blinded, crossover study. Each of 6 dogs received 3 treatments at 1-week intervals. During all anesthetic episodes, dogs received 0.05 mg/kg BW acepromazine. Approximately 25 min later, dogs were given physiological saline (control) or tramadol [3 mg/kg BW (TR3) or 5 mg/kg BW (TR5)]. All drugs were administered intravenously. Variables evaluated included heart rate (HR), respiratory rate (RR), systolic, mean, and diastolic blood pressures (SAP, MAP, and DAP), and sedation [by use of a simple descriptive scale (SDS, range: 0 to 3) and a numeric rating scale (NRS, range: 0 to 10)]. Variables were recorded 25 min after acepromazine and for 80 min after saline or tramadol. Acepromazine administration resulted in mild sedation in most dogs and decreased RR, SAP, MAP, and DAP in all treatments. Tramadol administration did not significantly increase SDS or NRS scores compared to acepromazine alone. The only exception to this rule was observed at 20 min after TR3, when NRS was higher in this group than in the control treatment. Administration of tramadol (TR3 and TR5) decreased HR. Under the conditions of this study, sedation induced by acepromazine with tramadol was similar to that of acepromazine alone. The main adverse effects of the combination were a decrease in blood pressure and HR, without clinical significance.
[Mh] Termos MeSH primário: Acepromazina/farmacologia
Sedação Consciente/veterinária
Cães
Tramadol/farmacologia
[Mh] Termos MeSH secundário: Acepromazina/administração & dosagem
Acepromazina/farmacocinética
Analgésicos Opioides/administração & dosagem
Analgésicos Opioides/farmacocinética
Analgésicos Opioides/farmacologia
Animais
Peso Corporal
Estudos Cross-Over
Sinergismo Farmacológico
Feminino
Hipnóticos e Sedativos/administração & dosagem
Hipnóticos e Sedativos/farmacocinética
Hipnóticos e Sedativos/farmacologia
Masculino
Tramadol/administração & dosagem
Tramadol/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Hypnotics and Sedatives); 39J1LGJ30J (Tramadol); 54EJ303F0R (Acepromazine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161014
[St] Status:MEDLINE


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[PMID]:27657709
[Au] Autor:Erickson RL; Terzi MC; Jaber SM; Hankenson FC; McKinstry-Wu A; Kelz MB; Marx JO
[Ad] Endereço:University Laboratory Animal Resources, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
[Ti] Título:Intraperitoneal Continuous-Rate Infusion for the Maintenance of Anesthesia in Laboratory Mice (Mus musculus).
[So] Source:J Am Assoc Lab Anim Sci;55(5):548-57, 2016.
[Is] ISSN:1559-6109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Intraperitoneal injectable anesthetics are often used to achieve surgical anesthesia in laboratory mice. Because bolus redosing of injectable anesthetics can cause unacceptably high mortality, we evaluated intraperitoneal continuous-rate infusion (CRI) of ketamine with or without xylazine for maintaining surgical anesthesia for an extended period of time. Anesthesia was induced in male C57BL/6J mice by using ketamine (80 mg/kg) and xylazine (8 mg/kg) without or with acepromazine at 0.1 mg/kg or 0.5 mg/kg. At 10 min after induction, CRI for 90 min was initiated and comprised 25%, 50%, or 100% of the initial ketamine dose per hour or 50% of the initial doses of both ketamine and xylazine. Anesthetic regimens were compared on the basis of animal immobility, continuous surgical depth of anesthesia as determined by the absence of a pedal withdrawal reflex, and mortality. Consistent with previous studies, the response to anesthetics was highly variable. Regimens that provided the longest continuous surgical plane of anesthesia with minimal mortality were ketamine-xylazine-acepromazine (0.1 mg/kg) with CRI of 100% of the initial ketamine dose and ketamine-xylazine-acepromazine (0.5 mg/kg) with CRI of 50% of the initial ketamine and xylazine doses. In addition, heart rate and respiratory rate did not increase consistently in response to a noxious stimulus during CRI anesthesia, even when mice exhibited a positive pedal withdrawal reflex, suggesting that these parameters are unreliable indicators of anesthetic depth during ketamine-xylazine anesthesia in mice. We conclude that intraperitoneal CRI anesthesia in mice prolongs injectable anesthesia more consistently and with lower mortality than does bolus redosing.
[Mh] Termos MeSH primário: Acepromazina/administração & dosagem
Anestesia/veterinária
Injeções Intraperitoneais/veterinária
Ketamina/administração & dosagem
Xilazina/administração & dosagem
[Mh] Termos MeSH secundário: Anestésicos/administração & dosagem
Animais
Esquema de Medicação
Quimioterapia Combinada
Frequência Cardíaca/efeitos dos fármacos
Ketamina/farmacologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Xilazina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics); 2KFG9TP5V8 (Xylazine); 54EJ303F0R (Acepromazine); 690G0D6V8H (Ketamine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160923
[St] Status:MEDLINE


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[PMID]:27351760
[Au] Autor:Bujold K; Hauer-Jensen M; Donini O; Rumage A; Hartman D; Hendrickson HP; Stamatopoulos J; Naraghi H; Pouliot M; Ascah A; Sebastian M; Pugsley MK; Wong K; Authier S
[Ad] Endereço:a CiToxLAB North America, Laval, Canada.
[Ti] Título:Citrulline as a Biomarker for Gastrointestinal-Acute Radiation Syndrome: Species Differences and Experimental Condition Effects.
[So] Source:Radiat Res;186(1):71-8, 2016 Jul.
[Is] ISSN:1938-5404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Animal models of hematopoietic and gastrointestinal acute radiation syndromes (ARS) have been characterized to develop medical countermeasures. Acute radiation-induced decrease of intestinal absorptive function has been correlated to a decrease in the number of intestinal crypt cells resulting from apoptosis and enterocyte mass reduction. Citrulline, a noncoded amino acid, is produced almost exclusively by the enterocytes of the small intestine. Citrullinemia has been identified as a simple, sensitive and suitable biomarker for radiation-induced injury associated with gastrointestinal ARS (GI-ARS). Here we discuss the effect of radiation on plasma citrulline levels in three different species, C57BL/6 mice, Göttingen minipigs and rhesus nonhuman primates (NHPs), measured by liquid chromatography tandem mass spectrometry (LC-MS/MS). The effects of experimental study conditions such as feeding and anesthesia were also examined on plasma citrulline levels in the NHPs. Both the mice and Göttingen minipigs were partial-body irradiated (PBI) with doses from 13-17 Gy and 8-16 Gy, respectively, whereas NHPs were total-body irradiated (TBI) with doses from 6.72-13 Gy. Blood samples were taken at different time points and plasma citrulline levels were measured in the three species at baseline and after irradiation. Basal plasma citrulline concentrations (mean ± SEM) in mice and minipigs were 57.8 ± 2.8 µM and 63.1 ± 2.1 µM, respectively. NHPs showed a basal plasma citrulline concentration of 32.6 ± 0.7 µM, very similar to that of humans (∼40 µM). Plasma citrulline progressively decreased after irradiation, reaching nadir values between day 3.5 and 7. The onset of citrulline recovery was observed earlier at lower radiation doses, while only partial citrulline recovery was noted at higher radiation doses in minipigs and NHPs, complete recovery was noted in mice at all doses. Plasma citrulline levels in NHPs anesthetized with ketamine and acepromazine significantly decreased by 35.5% (P = 0.0017), compared to unanesthetized NHPs. In the postprandial state, citrulline concentrations in NHPs were slightly but significantly decreased by 12.2% (P = 0.0287). These results suggest that plasma citrulline is affected by experimental conditions such as anesthesia and feeding.
[Mh] Termos MeSH primário: Síndrome Aguda da Radiação/sangue
Citrulina/sangue
Gastroenteropatias/sangue
[Mh] Termos MeSH secundário: Acepromazina/farmacologia
Síndrome Aguda da Radiação/complicações
Animais
Biomarcadores/sangue
Citrulinemia/complicações
Ingestão de Alimentos
Gastroenteropatias/complicações
Ketamina/farmacologia
Camundongos
Especificidade da Espécie
Suínos
Porco Miniatura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 29VT07BGDA (Citrulline); 54EJ303F0R (Acepromazine); 690G0D6V8H (Ketamine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:160629
[St] Status:MEDLINE
[do] DOI:10.1667/RR14305.1


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[PMID]:27243152
[Au] Autor:Gerritsmann H; Stalder GL; Kaczensky P; Buuveibaatar B; Payne J; Boldbaatar S; Walzer C
[Ad] Endereço:1 Research Institute of Wildlife Ecology, Department of Integrative Biology and Evolution, University of Veterinary Medicine, Vienna, Savoyenstraße 1, 1160 Vienna, Austria;
[Ti] Título:Arterial pH and Blood Lactate Levels of Anesthetized Mongolian Khulan ( Equus hemionus hemionus) in the Mongolian Gobi Correlate with Induction Time.
[So] Source:J Wildl Dis;52(3):642-6, 2016 Jul.
[Is] ISSN:1943-3700
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Research and conservation of wide-ranging wild equids in most cases necessitate capture and handling of individuals. For free-roaming Mongolian khulan ( Equus hemionus hemionus), also known as the khulan, capture involves a strenuous, high-speed chase, and physiologic responses have yet to be elucidated. We analyzed sequential arterial blood gas (ABG) samples as a proxy for respiratory and metabolic status of khulan during capture-related anesthesia. We recorded precise chase and induction times and monitored vital parameters and ABG from free-ranging khulan during anesthesia performed for GPS collaring. At the initiation of anesthesia, animals had ABG values similar to those recorded for thoroughbred horses ( Equus caballus ) after maximal exercise. Longer induction times resulted in higher arterial pH (P<0.001) and lower blood lactate (P<0.002). This trend of improvement continued over the course of anesthesia. The most important factor explaining pH and lactate was the time that elapsed between cessation of the chase and obtaining the first ABG sample, which, under field conditions, is tightly linked to induction time. All animals recovered uneventfully. Our data show that khulan recover and shift their metabolic status back toward expected normal values during opioid-based field anesthesia.
[Mh] Termos MeSH primário: Anestesia/veterinária
Equidae/sangue
Hipnóticos e Sedativos/farmacologia
Ácido Láctico/sangue
Esforço Físico
[Mh] Termos MeSH secundário: Acepromazina/administração & dosagem
Acepromazina/farmacologia
Analgésicos Opioides/administração & dosagem
Analgésicos Opioides/farmacologia
Animais
Butorfanol/administração & dosagem
Butorfanol/farmacologia
Antagonistas de Dopamina/administração & dosagem
Antagonistas de Dopamina/farmacologia
Combinação de Medicamentos
Quimioterapia Combinada
Etorfina/administração & dosagem
Etorfina/farmacologia
Feminino
Concentração de Íons de Hidrogênio
Hipnóticos e Sedativos/administração & dosagem
Imidazóis/administração & dosagem
Imidazóis/farmacologia
Imobilização/veterinária
Masculino
Mongólia
Fatores de Tempo
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Dopamine Antagonists); 0 (Drug Combinations); 0 (Hypnotics and Sedatives); 0 (Imidazoles); 33X04XA5AT (Lactic Acid); 42M2Y6NU9O (Etorphine); 54EJ303F0R (Acepromazine); 7N8K34P2XH (detomidine); QV897JC36D (Butorphanol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160601
[St] Status:MEDLINE
[do] DOI:10.7589/2015-07-198



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